2010 Doctor of Philosophy, Department of Mathematics, Imperial College London, UK

James Bentham

Education 2010 Doctor of Philosophy, Department of Mathematics, Imperial College London, UK 2006 Master of Science (Distinction), Probability and Statistics, University of Sheffield, UK 2000 Master of Engineering, Engineering (Civil), University of Warwick, UK 2000 Bachelor of Engineering, Engineering (Civil), University of Warwick, UK

Professional experience 2013- Research Associate, Department of Epidemiology and Biostatistics, Imperial College London, UK 2013-2016 Honorary Research Fellow, Department of Medical and Molecular Genetics, King's College London, UK 2010-2013 Research Associate, Department of Medical and Molecular Genetics, King's College London, UK 2010 Research Associate, Rheumatology Section, Imperial College London, UK

Conference talks 2016 China Heart Congress, Beijing, China. Worldwide patterns and mortality consequences of cardiometabolic risk factors. 2011 Platform presentation, American Society of Human Genetics Meeting/International Congress of Human Genetics, Montreal, Canada. Novel loci identified by the largest genome-wide association study of lupus to date. 2009 Discovery Science 12th International Conference, Porto, Portugal. Detecting new kinds of patient safety incidents. 2009 Royal Statistical Society 175th Anniversary Conference, Edinburgh, UK. Assessing results produced by a text mining algorithm.

Invited talk 2008 Royal Statistical Society Statistical Computing Section meeting on text mining (natural language processing). Detecting anomalies in free text.

Teaching 2014 Global Health Short Course, Imperial College London, UK. Delivered lecture describing recent trends in global public health. 2014 Chronic Disease Epidemiology and Burden of Disease Course, Imperial College London, UK. Gave lecture describing the effects of inequalities on non-communicable disease outcomes. 2012 European Science Foundation Statistical Genetics Course, King’s College London, UK. Developed course content, gave lectures providing an introduction to statistical analysis of genetic data and led practical sessions.

Grants 2012 Arthritis Research UK Travel Support Grant, £1,500. 2011 Arthritis Research UK Travel Support Grant, £1,250.

Prize 2015 Early Career Researchers Symposium, School of Public Health, Imperial College London, UK. A century of adult human height in the world’s countries. Best presentation award. Publications * equal contributions; † on behalf of the NCD Risk Factor Collaboration (NCD-RisC) 1. Zhou B, Bentham J*, Di Cesare M*, Bixby H, Danaei G, Cowan MJ, Paciorek CJ, Singh G, Hajifathalian K, Bennett JE, Taddei C, Bilano V, Carrillo-Larco RM, Djalalinia S, Khatibzadeh S, Lugero C, Peykari N, Zhang WZ, Lu Y, Stevens GA, Riley LM, Bovet P, Elliott P, Gu D, Ikeda N, Jackson RT, Joffres M, Kengne AP, Laatikainen T, Lam TH, Laxmaiah A, Liu J, Miranda JJ, Mondo CK, Neuhauser HK, Sundström J, Smeeth L, Sori 2. M, Woodward M, Ezzati M.† Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants. Lancet 2017; 389:37-55. 3. Ueda P, Woodward M, Lu Y, Hajifathalian K, Al-Wotayan R, Aguilar-Salinas CA, Ahmadvand A, Azizi F, Bentham J, Cifkova R, Di Cesare M, Eriksen L, Farzadfar F, Ferguson TS, Ikeda N, Khalili D, Khang Y-H, Lanska V, León-Muñoz L, Magliano D, Margozzini P, Msyamboza KP, Mutungi GN, Oh K, Oum S, Rodríguez-Artalejo F, Rojas-Martinez R, Valdivia G, Wilks R, Shaw JE, Stevens GA, Tolsrup J, Zhou B, Salomon JA, Ezzati M, Danaei G. Cardiovascular risk charts for 182 countries: application of laboratory- based and office-based risk scores to global populations. Lancet Diabetes and Endocrinology 2017; forthcoming. 4. Bentham J*, Di Cesare M*, Stevens GA, Zhou B, Bixby H, Cowan MJ, Fortunato L, Bennett JE, Danaei G, Hajifathalian K, Lu Y, Riley LM, Laxmaiah A, Kontis V, Paciorek CJ, Riboli E, Ezzati M.† A century of trends in adult human height. eLife 2016; e13410. 5. Morris DL*, Sheng Y*, Zhang Y*, Wang Y*, Zhu Z*, Tombleson P*, Chen L, Cunninghame Graham DS, Bentham J, Chen R, Zuo X, Wang T, Wen L, Yang C, Liu L, Yang L, Li F, Huang Y, Yin X, Yang S, Rönnblom L, Fürnrohr BG, Voll RE, Schett G, Costedoat–Chalumeau N, Gaffney PM, Lau YL, Zhang X, Yang W, Cui Y, Vyse TJ. Meta-analysis of Chinese and European GWAS identifies 10 novel SLE associated loci and provides evidence for increased genetic risk of disease in Chinese. Nature Genetics 2016; 48:940-946. 6. Zhou B*, Lu Y*, Hajifathalian K*, Bentham J*, Di Cesare M*, Danaei G*, Bixby H, Cowan MJ, Ali MK, Taddei C, Lo W-C, Reis-Santos B, Stevens GA, Riley LM, Miranda JJ, Bjerregaard P, Rivera JA, Fouad HM, Ma G, Mbanya JCN, McGarvey ST, Mohan V, Onat A, Pilav A, Ramachandran A, Ben Romdhane H, Paciorek CJ, Bennett JE, Ezzati M.† Worldwide trends in diabetes since 1980: pooled analysis of 751 population-based measurement studies with over 4.4 million participants. Lancet 2016; 387:1513-1530. 7. Di Cesare M*, Bentham J*, Stevens GA*, Zhou B, Danaei G, Lu Y, Bixby H, Cowan MJ, Riley LM, Hajifathalian K, Fortunato L, Taddei C, Bennett JE, Ikeda N, Khang Y-H, Kyobutungi C, Laxmaiah A, Li Y, Lin H-H, Miranda JJ, Mostafa A, Turley ML, Paciorek CJ, Gunter M, Ezzati M.† Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants. Lancet 2016; 387:1377-1396. 8. Bentham J*, Morris DL*, Cunninghame Graham DS, Pinder CL, Tombleson P, Behrens TW, Martín J, Fairfax BP, Knight JC, Chen L, Replogle J, Syvänen A-C, Rönnblom L, Graham RR, Wither JE, Rioux JD, Alarcón- Riquelme ME, Vyse TJ. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nature Genetics 2015; 47:1457-1464. 9. Danaei G*, Fahimi S*, Lu Y*, Zhou B*, Hajifathalian K, Di Cesare M, Lo W-C, Reis-Santos B, Cowan MJ, Shaw JE, Bentham J, Lin JK, Bixby H, Magliano D, Bovet P, Miranda JJ, Khang Y-H, Stevens GA, Riley LM, Ali MK, Ezzati M.† Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants. Lancet Diabetes & Endocrinology 2015; 3:624-637. 10. Bentham J, Vyse TJ. The development of genome-wide association studies and their application to complex diseases, including lupus. Lupus 2013; 22:1205-1213. 11. Bentham J, Hand DJ. Data mining from a patient safety database: the lessons learned. Data Mining and Knowledge Discovery 2012; 24:195-217. 12. Bentham J, Hand DJ. Detecting new kinds of patient safety incidents. Proceedings of the 12th International Conference, Discovery Science; 2009; Porto, Portugal. Berlin: Springer-Verlag; 2009. p.51-65.