The RACK1 Scaffold Protein: a Dynamic Cog in Cell Response Mechanisms

MOLECULAR PHARMACOLOGY

December 2002 Volume 62 Number 6 http://molpharm.aspetjournals.org ISSN 0026-895X

MINIREVIEW The RACK1 Scaffold Protein: A Dynamic Cog in Cell Response Mechanisms Angela McCahill, Jim Warwicker, Graeme B. Bolger, Miles D. Houslay, and Stephen J. Yarwood 1261

ARTICLES A^-(Piperidin-l-yl)-5-(4-chlorophenyl)-l-(2,4-dichlorophenyl)-4-methyl-lf/-pyrazole-3-carboxamide (SR141716A) Interaction with LYS 3.28(192) Is Crucial for Its Inverse Agonism at the Cannabinoid CBl Receptor Dow P. Hurst, Diane L. Lynch, Judy Barnett-Norris, Stephen M. Hyatt, Herbert H. Seltzman, Miao Zhong, Zhao-Hui Song, Jingjiang Nie, Deborah Lewis, and Patricia H. Reggio 1274

Characterization of Two Pharmacophores on the Multidrug Transporter P-Glycoprotein Alexia Garrigues, Nicolas Loiseau, Marcel Delaforge, Jacques Ferte, Manuel Garrigos, Francois Andre, and Stephane Orlowski 1288

Novel Roles of Liver X Receptors Exposed by Gene Expression Profiling in Liver and Adipose Tissue Thomas M. Stulnig, Knut R. Steffensen, Hui Gao, Mark Reimers, Karin Dahlman-Wright, Gertrud U. Schuster, and Jan-Ake Gustafsson 1299

Ilj3-Hydroxyprogesterone Acts as a Mineralocorticoid Agonist in Stimulating Na 1 Absorption in Mammalian Principal Cortical Collecting Duct Cells Marie-Edith Rafestin-Oblin, Jerome Fagart, Anny Souque, Cendrine Seguin, Marcelle Bens, and Alain Vandewalle 1306

Expression Profile and Up-Regulation of Prax-1 mRNA by Antidepressant Treatment in the Rat Brain Pascale Chardenot, Christine Roubert, Sylvaine Galiegue, Pierre Casellas, Gerard Le Fur, Philippe Soubrie, and Florence Oury-Donat 1314

Thiopurine Metabolism and Identification of the Thiopurine Metabolites Transported by MRP4 and MRP5 Overexpressed in Human Embryonic Kidney Cells P. R. Wielinga, G. Reid, E. E, Challa, I. van der Heijden, L. van Deemter, M. de Haas, C. Mol, A. J. Kuil, E. Groeneveld, J. D. Schuetz, C. Brouwer, R. A. De Abreu, J. Wijnholds, J. H. Beijnen, and P. Borst _ _ ----.______. 1321 Mss4 Gene Is Up-Regulated in Rat Brain after Chronic Treatment with Antidepressant and Down- Regulated When Rats Are Anhedonic Christian Andriamampandry, Claude Muller, Catherine Schmidt-Mutter, Serge Gobaille, Michael Spedding, Dominique Aunis, and Michel Maitre 1332 i Phospholipase D Activation by Endogenous 5-Hydroxytryptamine 2C Receptors Is Mediated by Ga 13 and Pertussis Toxin-Insensitive GjBy Subunits L, McGrew, M. S. S. Chang, and E. Sanders-Bush

1339 Transcriptional Regulation of the Rat Bradykinin B2 Receptor Gene: Identification of a Silencer Element Heloisa A. Baptista, Maria C. W. Avellar, Ronaldo C, Araujo, Jorge L, Pesquero, Joost P. Schanstra, Jean L. Bascands, Jean P. Esteve, Antonio C. M. Paiva, Michael Bader, and Jodo B. Pesquero

1344 Inhibition of Protein Tyrosine/Mitogen-Activated Protein Kinase Phosphatase Activity Is Associated with D2 Dopamine Receptor Supersensitivity in a Rat Model of Parkinson's Disease Xuechu Zhen, Claudio Torres, Guoping Cai, and Eitan Friedman 1356 Discovery of Novel Targets of Quinoline Drugs in the Human Purine Binding Proteome Paul R. Graves, Jesse J. Kwiek, Patrick Fadden, Rupa Ray, Klaas Hardeman, Andrew M. Coley, Michael Foley, and Timothy A. J. Haystead 1364

A3 Adenosine Receptors in Human Astrocytoma Cells: Agonist-Mediated Desensitization, Internalization, and Down-Regulation M. L. Trincavelli, D, Tuscano, M. Marroni, A. Falleni, V. Gremigni, S. Ceruti, M. P. Abbracchio, K. A. Jacobson, F. Cattabeni, and C. Martini 1373

Mechanism of Extracellular Signal-Regulated Kinase Activation by the CB-L Cannabinoid Receptor Ismael Galve-Roperh, Daniel Rueda, Teresa Gomez del Pulgar, Guillermo Velasco, and Manuel Guzman 1385

Alteration of Intrinsic Biological Rhythms during Interferon Treatment and Its Possible Mechanism Satoru Koyanagi and Shigehiro Ohdo 1393 c-Myc Exerts a Protective Function through Ornithine Decarboxylase against Cellular Insults Jong Kuk Park, Young Min Chung, Seongman Kang, Jae-Uk Kim, Yun-Taik Kim, Hyung Jung Kim, Yeul Hong Kim, Jun Suk Kim, and Young Do Yoo 1400 Enhancement of Metabolic Oxidative Stress-Induced Cytotoxicity by the Thioredoxin Inhibitor 1- Methylpropyl 2-Imidazolyl Disulfide Is Mediated through the ASK1-SEK1-JNK1 Pathway Yong J. Lee, Jin H. Kim, Jun Chen, and Jae J. Song 1409 Characteristics of Block by Pb2+ of Function of Human Neuronal L-, N-, and R-Type Ca 2+ Channels Transiently Expressed in Human Embryonic Kidney 293 Cells Shuangqing Peng, Ravindra K Hajela, and William D. Atchison 1418 Mutation of Asn293 to Asp in Transmembrane Helix VI Abolishes Agonist-Induced but Not Constitutive Activity of the /32-Adrenergic Receptor Annette Hannawacker, Cornelius Krasel, and Martin J. Lohse 1431

P2XX Receptor-Deficient Mice Establish the Native P2X Receptor and a P2Y6-Like Receptor in Arteries Catherine Vial and Richard J. Evans 1438 Overexpression of Protein Kinase C£ Confers Protection Against Antileukemic Drugs by Inhibiting the Redox-Dependent Sphingomyelinase Activation Christine Bezombes, Aurelie de Thonel, Andriana Apostolou, Thierry Louat, Jean-Pierre Jaffrezou, Guy Laurent, and Anne Quillet-Mary 1446 Assembly with the Kv/31.3 Subunit Modulates Drug Block of hKvl.5 Channels Teresa Gonzalez, Ricardo Navarro-Polanco, Cristina Arias, Ricardo Caballero, Ignacio Moreno, Eva Delpon, Juan Tamargo, Michael M, Tamkun, and Carmen Valenzuela 1456 Opioid Agonists Differentially Regulate /x-Opioid Receptors and Trafficking Proteins in Vivo Minesh B. Patel, Chintan N. Patel, Vikram Rajashekara, and Byron C. Yoburn

1464 Commitment of Activated T Cells to Secondary Responsiveness Is Enhanced by Signals Mediated by cAMP-Dependent Protein Kinase A-I Monika Vig, Anna George, Ranjan Sen, Jeannine Durdik, Satyajit Rath, and Vineeta Bat

1471 Identification of PKCa Isoform-Specific Effects in Cardiac Myocytes Using Antisense Phosphor othio ate Oligonucleotides Risto Kerkeld, Mika lives, Sampsa Pikkarainen, Heikki Tokola, Jarkko Ronkainen, Olli Vuolteenaho, Juhani Leppdluoto, and Heikki Ruskoaho 1482 Analogs of WIN 62,577 Define a Second Allosteric Site on Muscarinic Receptors S. Lazareno, A. Popham, and N. J. M, Birdsall 1492 Reduction of G Protein-Coupled Receptor Kinase 2 Expression in U-937 Cells Attenuates H2 Histamine Receptor Desensitization and Induces Cell Maturation Natalia Fernandez, Federico Monczor, Bibiana Lemos, Cintia Notcovich, Alberto Baldi, Carlos Davio, and Carina Shayo 1506 Mechanisms Underlying Nonsteroidal Anti-Inflammatory Drug-Induced p27 if(pi Expression. Yu-Chun Huang, Lea-Yea Chuang, and Wen-Chun Hung 1515