WSU School of Medicine Format

John H. Hannigan, Ph.D. – Abbreviated CV Page 1

Date of Preparation: October 12, 2015

JOHN H. HANNIGAN, Ph.D.

Professor of Obstetrics Professor of Psychology

Office Address: Merrill Palmer Skillman Institute (MPSI) Phone Numbers: Wayne State University MPSI: 313-644-2503 The Charles Lang Freer House Mott Center (Main): 313-577-1337 71 East Ferry, Detroit, MI 48202 Psychology: 313-577-2087

EDUCATION College Dates Major Field Degree Date

Fairfield University 9/71-5/75 Psychology B.S. 1975 Employed in Industry 6/75-5/79 ------Binghamton University 6/79-5/83 Psychology M.A. 1981 Physiological Psychology Ph.D. 1983

TRAINING (Selected) NICHD Postdoctoral Trainee Intellectual and Developmental Disabilities Research Center, UCLA 6/83 8/84 Visiting Professor (Sabbatical) 9/07-3/08 Departments of Psychiatry and Radiology, Penn State University Medical School, Hershey, PA

Other Professional Appointments (Selected)

NIAAA Fetal Alcohol Research Center; Component PI & Assoc. Director 1992-1998

FAStar: Fetal Alcohol Syndrome Treatment and Referral service, Director 1997-2012 Reproductive Sciences and Developmental Biology Graduate Program Core Faculty / Professor 2005 - present Translational Neuroscience Program (TNP) Faculty since 5/06 Merrill-Palmer-Skillman Institute for Child and Family Development Deputy Director 2008-2015 Center for Urban Responses to Environmental Stressors (CURES) Community Outreach and Engagement Core: Co-Coordinator 3/13 – 6/15 Coordinator, Faculty Professional Development 6/15 - present

Professional Societies (Selected) International Society for Developmental Psychobiology (ISDP) 1983-present Research Society on Alcoholism (RSA) 1987-present Fetal Alcohol Syndrome Study Group of RSA 1987-present Neurobehavioral Teratology Society (NBTS) 1989-2001 John H. Hannigan, Ph.D. Page 2 Current University and Professional Service Merrill Palmer Skillman Institute Director, Graduate Training Program 2010 - 2015 The Freer House, Board of Directors since 2008

Developmental Exposure Alcohol Research Center (NIAAA P30) 8/02 - present State University of New York: Upstate Medical University / Binghamton University External Advisory Board, Member State of Michigan Department of Public Health FASD Task Force, Member 10/05 - present NIAAA Collaborative Initiative for Fetal Alcohol Spectrum Disorders Science Advisory Board 6/09 – present Chair 2/11 – present

University of New Mexico Alcohol Research Center (NIAAA P30) 10/12 - present Program Advisory Committee, Member

Fetal Alcohol Spectrum Disorders (FASD) Center for Excellence 2013-2015 Substance Abuse and Mental Health Services Administration (SAMHSA) Center for Substance Abuse Prevention (CSAP) FASD Expert Panel, Member

Children’s Health Alliance for Research in Michigan (C.H.A.R.M.) 6/15 – present Executive Committee, Member

TEACHING (Selected)

Drugs, Behavior and Society PSY2080 W’03; Winters since ‘05

Reproductive Sciences: Teratology – PSL7730/MTX7730 F’08; F’10; F’13 (next: F’16) Principles in Reproductive Biology - PSL7715 2010-2012; 2014 Lecture: Teratology

Anatomy & Embryology I - ANA7080 Falls since 2002 Lecture: FASD & Craniofacial Development

Mentorship (Selected) Recent/ Current Graduate Student Supervision

Brian Klassen, PhD (2014) Clinical Psychology PhD Student, WSU Nicole Nowak, PhD (2012) Behav. & Cog. Neuroscience Postdoc, Univ Wisconsin – Milwaukee Ann Carrellas, MA; MSW (2013) Social Work PhD Student, WSU Sandra King, MSW (2014) Sociology PhD Student, WSU Amy E. Graham (2015) Clinical Psychology MA Student, WSU

John H. Hannigan, Ph.D. Page 3

Thesis and Dissertation Committees Chaired: (with former trainees’s current or last known position): Betty A. (Blanchard) Boechler, PhD (1990) Program & Data Analyst, Louisiana Heath Care Review Thesis (1987): Gender-Influenced Spatial Learning Deficits After Prenatal Alcohol Exposure in Rats Dissertation: The Influence of Neonatal Testosterone on Behavioral Effects of Prenatal Ethanol Exposure in Male Rats

Surilla Randall, PhD (2001) Biopsychology Area [MBRS] Research Manager, Henry Ford Health Systems, Detroit, MI (Former Chair, Math & Sci., Benedictine H.S.) ® Thesis (1998): Effects of In Utero Alcohol and Postweaning Ritalin on Locomotion and D1 and D2 Receptors Dissertation (2001): The Effects of Alcohol Exposure on Cortical Neuron Differentiation and Nerve Growth Factor

Beth A. (Nordstrom) Bailey PhD (2001) Developmental Area Associate Professor, Department of Family Medicine, Eastern Tennessee University Dissertation (2001): Violence Exposure & Child Behavioral, Emotional Problems: Moderating Role of Maternal Acceptance

Bernadette M. Cortese, PhD (2003) Behav. & Cog. Neuroscience Assistant Professor, Department of Psychiatry & Behav. Sciences, Medical University of South Carolina Thesis (1997): Effects of Prenatal Ethanol Exposure on Hippocampal Theta Activity in the Rat Dissertation (2003): Magnetic Resonance Spectroscopic Imaging in Children with FAS and Fetal Alcohol Effects

Shonagh K. O’Leary-Moore, PhD (2007) Behav. & Cog. Neuroscience Employed in IT Science Support Industry (NIAAA NRSA Awardee) Formerly: Assistant Professor of Psychiatry, Bowles Alcohol Research Center, University of North Carolina Thesis (2004): Reversal Learning and Fetal Alcohol Exposure: Effects of Time of Exposure & Age of Testing Dissertation (2007): Developmental and Regional Neurochemical Profiles after Neonatal Alcohol Exposure Using High- Resolution NMR Spectroscopy

Neil C. Dodge (Chair; for Dr. J. Jacobson) Behav. & Cog. Neuroscience; Research Assistant, Dept. Psychiatry Thesis (2013): Protective Effects of the Alcohol Dehydrogenase-ADH1B Allele on Behavior Problems in Adolescents Exposed to Alcohol during Pregnancy Dissertation (in progress): Virtual Place Learning/Navigation in Humans with Fetal Alcohol Spectrum Disorders

Grants, Contracts and Other Funding (Selected)

Active

NIEHS P30 ES020957-01A1 (Co-PI for “Core”: Co-PI: P. Lichtenberg) 2014-2015 Community Outreach and Engagement Core 2014-2015 Faculty Development Coordinator 2015-present Center For Urban Responses to Environmental Stressors (CURES) (PI/PD: M. Runge Morris) $2,501,000

Pending

NIAAA/NICHD R01-AA024756-01 (Co-PI; Co-PI: L.M. Chiodo) Impact of Prenatal Alcohol Exposure and Responses to Alcohol Odors and Tastes: Relationships to Problem Drinking in Young Adults (SUBMITTED, JUNE, 2015) John H. Hannigan, Ph.D. Page 4

Recently Completed Grants and Contracts (Selected)

Kresge Foundation (Co-PI; Co-PIs: A. Miller; S. Elliott) $245,970 2013-2015 Promoting High-Quality Early Childhood Education in the Woodward Corridor of Detroit

NIDA R01 DA022419-01 (Key Investigator; PI: V. Delaney-Black) $3,745,437 6/2008-12/2014 Teens at Risk: Prenatal Cocaine and Postnatal Challenges

PNC Foundation (Co-PI; Co-PIs: A. Miller; S. Elliott) $15,000 9/2013-8/2014 Coaching for Excellence in Early Childhood Education Practice in Detroit

Colina Foundation (PI) $3,000 6/2013-12/2013 Support for CHAMPS Summer Camp Community Intervention Project

Carls Foundation (PI) $150,000 1/2005-12/2013 Support for Fetal Alcohol Spectrum Disorders Community Intervention Project Originally “Support for: Fetal Alcohol Syndrome Treatment and Referral Service (FAStar)”

First Children’s Finance (Co-PI; Co-PI: A. Miller) $50,000 10/2011-9/2013 Multiservice Growth and Fiscal Management for WSU Early Childhood Centers

NIDA R21 DA019151-01 (Co-PI; PI: S.E. Bowen) $402,500, A Preclinical Model of Adolescent Toluene Abuse in Rats, 06/08

NIDA R01 DA0116373 (Investigator; PI: V. Delaney-Black) $2,404,615, Consequences of Prenatal Cocaine in Adolescents, 03/08 ( S upplement: R01 DA15832; $424,879 Extended Consequences of Prenatal Cocaine in Adolescents

Selected Publications - from a total of 121 (as of 09/04/15) * = STUDENT/TRAINEE CO-AUTHOR *Blanchard, B.A., Riley, E.P., Hannigan, J.H. (1987) Deficits on a spatial navigation task following prenatal exposure to ethanol. Neurobehavioral Toxicology and Teratology 9, 253-258. PMID: 3627089

Hannigan, J.H., Riley, E.P. (1988) Prenatal ethanol exposure alters gait in rats. Alcohol 5, 451-454. PMID: 3245887

Hannigan, J.H., Berman, R.F., Zajac, C.S. (1993) Environmental enrichment and the behavioral effects of prenatal exposure to alcohol in rats. Neurotoxicology and Teratology 15, 261-266. PMID: 8413080

Hannigan, J.H., Martier, S.S., Naber, J.M. (1995) Independent associations among maternal alcohol consumption and infant thyroxine levels and pregnancy outcome. Alcoholism: Clinical and Experimental Research 19, 135-141. PMID: 7771639

Abel, E.L., Hannigan, J.H. (1995) Maternal risk factors in fetal alcohol syndrome: Provocative and permissive influences. Neurotoxicology and Teratology. 17, 445-462 PMID: 7565491

Berman, R.F., Hannigan, J.H., Sperry, M.A., Zajac, C.S. (1996) Prenatal alcohol exposure eliminates the effects of environmental enrichment on hippocampal dendritic spine density. Alcohol. 13, 209-216. PMID: 8814658

Hannigan, J.H., Berman, R.F. (2000) Amelioration of fetal alcohol-related neurodevelopmental disorders in rats: Exploring pharmacological and environmental treatments. Neurotoxicology and Teratology. 22, 103-111. PMID: 10642119 John H. Hannigan, Ph.D. Page 5

Berman, R.F., Hannigan, J.H. (2000) Effects of prenatal alcohol exposure in rats on the hippocampus: Spatial behavior, electrophysiology and neuroanatomy. Hippocampus. 10, 94-110. PMID: 10706221

Stark, K.D., Beblo, S., Murthy, M., Buda-Abela, M., Janisse, J., Rockett, H., Whitty, J.E., Martier, S.S., Sokol, R.J., Hannigan, J.H., Salem, N. Jr. (2005) Comparison of plasma and erythrocyte total fatty acid composition from African-American women at 24 weeks gestation, infant delivery and 3 months postpartum. Journal of Lipid Research. 46, 516-525. PMID: 15604519

Stark, K., Beblo, S., Murthy, M., Whitty, J.E., Buda-Abela, M., Janisse, J., Rockett, H., Martier, S.S., Sokol, R.J., Hannigan, J.H., Salem, N. Jr. (2005) Alcohol consumption in pregnant, Black women is associated with decreased plasma and erythrocyte docosahexaenoic acid. Alcoholism: Clinical and Experimental Research. 29,130-140. [ACER HIGHLIGHTED ARTICLE] PMID: 15654301

Bowen, S.E., *Batis, J.C., *Mohammadi, M.H., Hannigan, J.H. (2005) Abuse pattern of gestational toluene exposure and early postnatal development in rats. Neurotoxicology and Teratology. 27, 105-116. PMID: 15681125

Beblo, S., Stark, K., Murthy, M., Janisse, J., Rockett, H., Whitty, J.E., Buda-Abela, M., Martier, S.S., Sokol, R.J., Hannigan, J.H., Salem, N., Jr. (2005) Effects of alcohol intake during pregnancy on docosahexaenoic acid and arachidonic acid in umbilical cord vessels of Black women. Pediatrics. 11, 194-203. PMID: 15687427

Nordstrom-Bailey, B., Sood, B.G., Sokol, R.J., Ager, J., Janisse, J., Hannigan, J.H., Delaney-Black, V. (2005) Gender and alcohol moderate prenatal cocaine effects on teacher-report of child behavior. Neurotoxicology and Teratology. 27,181-189. PMID: 15734269 Stark, K.D., Pawlosky, R.J., Beblo, S., Murthy, M., Flanagan, V.P., Janisse, J., Buda-Abela, M., Rockett, H., Whitty, J.E., Sokol, R.J., Hannigan, J.H., Salem, N. Jr. (2005) Status of plasma folate after folic acid fortification of the food supply in pregnant African-American women and the influences of diet, smoking and alcohol consumption. American Journal of Clinical Nutrition. 81, 669-677. PMID: 15755838

*Cortese, B.M., Moore, G.J., *Bailey, B.A., Jacobson, S.W., Delaney-Black, V., Hannigan, J.H. (2006) Magnetic resonance and spectroscopic imaging in prenatal alcohol-exposed children: Preliminary findings in the caudate nucleus. Neurotoxicology and Teratology. 28, 597-606. [DR. CORTESE’S DISSERTATION RESEARCH] PMID: 16996247

*O’Leary-Moore, S.K., Galloway, M.P., McMechan, A., Hannigan, J.H., Bowen, S.E. (2007) Region-dependent alterations in glutamate and GABA measured by high-resolution magnetic resonance spectroscopy following acute binge inhalation of toluene in juvenile rats. Neurotoxicology and Teratology. 29, 466-475. PMID: 17466488

Hannigan, J.H., *O’Leary-Moore, S.K., Berman, R.F. (2007) Postnatal environmental or experiential amelioration of neurobehavioral effects of perinatal alcohol exposure in rats. Neuroscience and Biobehavioral Reviews. 31, 202- 211. PMID: 16911827

*O’Leary-Moore, S.K., McMechan, A., Galloway, M.P., Hannigan, J.H. (2008) Neonatal alcohol-induced region- dependent changes in rat brain neurochemistry measured by high-resolution magnetic resonance spectroscopy. Alcoholism: Clinical & Experimental Research. 32:1741-1751. [DR. O’LEARY-MOORE’S DISSERTATION RESEARCH] PMID: 18631322

Chiodo, L.M., Janisse, J., Delaney-Black, V., Sokol, R.J., Hannigan, J.H. (2009) A metric of maternal prenatal risk drinking predicts neurobehavioral outcomes in preschool children. Alcoholism: Clinical & Experimental Research. 33:634-644. [ ACER HIGHLIGHTED ARTICLE] PMID: 19183137 John H. Hannigan, Ph.D. Page 6

Bowen, S.E., Hannigan, J.H., Irtenkauf, S., *Stefanski, A. (2009) Alterations in fetal morphology following abuse patterns of toluene exposure. Reproductive Toxicology. 27:161-169. (Epub 21 Jan 2009) PMID: 19429395; PMC2680795 1. *O’Leary-Moore, S.K., Galloway, M.P., McMechan, A.P., Irtenkauf, S., Hannigan, J.H., Bowen, S.E. (2009) Neurochemical changes after acute binge toluene inhalation in adolescent and adult rats: A high-resolution MR spectroscopy study. Neurotoxicology and Teratology, 31: 382–389. PMID: 19628036

Kelly, S.J., Goodlett, C.R., Hannigan, J.H. (2009) Animal models of fetal alcohol spectrum disorders: Impact of the social environment. Developmental Disabilities Research Reviews 15, 200-208. PMID: 19731387

Hannigan, J.H., Bowen, S.E. (2010) Reproductive toxicology and teratology of abused toluene. Systems Biology in Reproductive Medicine 56, 184-200. PMID: 20377315

Hannigan, J.H., Chiodo, L.M., Sokol, R.J., Janisse, J., Ager, J., Greenwald, M.K., Delaney-Black, V. (2010) A 14- year retrospective maternal report of alcohol consumption in pregnancy predicts pregnancy and teen outcomes. Alcohol, 44:583-594. PMID: 20036487

Chiodo, L.M., Delaney-Black, V., Janisse, J., Sokol, R.J., Hannigan, J.H. (2010) Validity of the T-ACE in pregnancy in predicting child outcome and risk drinking. Alcohol, 44:595-603. PMID: 20053522

Delaney-Black, V., Chiodo, L.M., Hannigan, J.H., Huestis, M.A., Greenwald, M.K., Janisse, J., Patterson, G. Ager, J., Sokol, R.J. (2010) Just say “I don’t”: Lack of concordance between teen self-report and measures of illicit drug use. Pediatrics, 126:887-893. PMID: 20974792

Delaney-Black, V., Chiodo, L.M., Hannigan, J.H., Greenwald, M.K., Janisse, J., Patterson, G., Huestis, M.A., Ager, J., Sokol, R.J. (2011) Prenatal and postnatal cocaine exposure predict teen cocaine use. Neurotoxicology and Teratology, 33, 110–119. PMID: 20609384

Chiodo, L.M., Bailey, B., Sokol, R.J., Janisse, J., Delaney-Black, V., Hannigan, J.H. (2012) Recognized spontaneous abortion in mid-pregnancy and patterns of pregnancy alcohol use. Alcohol, 46:261-267. PMID: 22440690 Hannigan, J.H., Delaney-Black, V. (2012) Faithful friends: Teen reporters of peer substance use. Addiction. 107:889-890. PMID: 22471572 Bowen, S.E., Hannigan, J.H. (2013) Binge toluene exposure in pregnancy and preweaning developmental consequences in rats. Neurotoxicology and Teratology. 38:29-35. PMID: 23597557

Chiodo, L.M., Delaney-Black, V. Sokol, R.J., Janisse, J., Pardo, Y., Hannigan, J.H. (2014) Increased cut-point of the TACER-3 screen reduces false positives without losing sensitivity in predicting risk alcohol drinking in pregnancy. Alcoholism: Clinical and Experimental Research. 38(5) 1401-1408. PMID: 24655071 Hannigan JH, Chiodo LM, Sokol RJ, Janisse J, Delaney-Black V. (2015) Prenatal alcohol exposure selectively enhances young adult perceived pleasantness of alcohol odors. Physiology & Behavior. 148:71-77. PMID: 25600468

*Callan, S.P., Bowen, S.E., Hannigan, J.H. (2015) Prenatal toluene exposure impairs performance in the Morris water maze in adolescent rats. Neuroscience. Accepted; doi:10.1016/j.neuroscience.2015.08.050 John H. Hannigan, Ph.D. Page 7

Maslowsky, J., Schulenberg, J., Chiodo, L.M., Hannigan, J.H., Greenwald, M., Janisse, J., Sokol, R.J., Delaney- Black, V. (2015) Parental support, mental health, and substance use in national and high-risk African American adolescent samples. Substance Abuse: Research and Treatment. Accepted.

BOOK Hannigan, J.H., (Editor), Spear, N.E., Spear, L.P., Goodlett, C.R., (Associate Editors) (1999) Alcohol and Alcoholism: Effects on Brain and Development. L.A. Erlbaum Associates: Mahwah, N.J.

Published Abstracts – over 225

Selected Invited Presentations (National and International) Alcohol Exposure and Maternal-Fetal Thyroid Function: Impact on Biobehavioral Maturation. May (1992) NIAAA Workshop on Alcohol and the Endocrine System, San Diego, CA. Behavioral Plasticity After Teratogenic Alcohol Exposure as Recovery of Function. April (1993) International Behavioral Neuroscience Society, Annual Meeting, Clearwater Beach, FL. Future Directions in Animal Research on Fetal Alcohol Syndrome. June (1992) Fetal Alcohol Syndrome Study Group of RSA, Annual Meeting, La Jolla, CA. Research Strategies in Detroit for Identifying At-Risk Drinking in Mothers and Identifying Affected Offspring. March (1994) Centers for Disease Control, Atlanta, GA. Testing Treatments for Fetal Alcohol Syndrome in Animal Models. October (1996) Addiction Research Institute, Russian Federation Ministry of Health, US/Russian Biomedical and Behavioral Research Collaboration in Alcohol Abuse and Alcoholism, Moscow, Russia. DNA methylation in newborn human blood is sensitive to prenatal alcohol exposure and related to child behavioral outcomes. June (2012) Fetal Alcohol Spectrum Disorders Study Group of Research Society on Alcoholism, Annual Meeting, San Francisco, CA. Alcohol Embryofetopathology in Rats, the Principles of Teratology, and the Clinical Relevance of Animal Models: A Demonstration from Studies of Hippocampal Dysfunction. September (1999) Keynote Address: 10th Annual Teratology Conference, German Anatomical Society. University of Greifswald, Greifswald, Germany. Treatment of Maternal Risk Drinking and Prevention of Fetal Alcohol Effects. March (2001) Liaison Section, The Royal College of Psychiatry, Substance Misuse Faculty, Residential Meeting, York, England. Discussant on “Ethics and Biomarkers for FASD.” June (2012) Fetal Alcohol Spectrum Disorders Study Group of Research Society on Alcoholism, Annual Meeting, San Francisco, CA. Getting Published: Dealing with Stupid Reviewers and Stubborn Editors. May (2014) Addiction Neuroscience Program and Psychology Department, IUPUI, Indianapolis, IN. Prenatal Alcohol Exposure is Associated with Altered Responses to Alcohol Odors in Older Teens. Feschrift for Norman E. Spear. May (2014) Center for Developmental Psychobiology and Department of Psychology, Binghamton University, Binghamton, NY Maternal Risk Factors: Evidence, Experience and FASD Research. April (2015) 6th International Conference on FASD. Vancouver, BC, Canada