Curriculum Vitae s59

1 CURRICULUM VITAE Name: Dr. Aubrey D.N.J. de Grey

Current post: Chief Science Officer, SENS Research Foundation Research area: the role and causes of all the accumulating and eventually pathogenic molecular and cellular side-effects of metabolism that constitute mammalian aging; the design of interventions to reverse and/or obviate this accumulation. Bio paragraph (e.g., if you have invited me to speak and are creating promotional material): Dr. Aubrey de Grey is a biomedical gerontologist based in Cambridge, UK and Mountain View, California, USA, and is the Chief Science Officer of SENS Research Foundation, a California-based 501(c)(3) charity dedicated to combating the aging process. He is also Editor-in-Chief of Rejuvenation Research, the world’s highest-impact peer-reviewed journal focused on intervention in aging. He received his BA and Ph.D. from the University of Cambridge in 1985 and 2000 respectively. His original field was computer science, and he did research in the private sector for six years in the area of software verification before switching to biogerontology in the mid-1990s. His research interests encompass the characterisation of all the accumulating and eventually pathogenic molecular and cellular side-effects of metabolism (“damage”) that constitute mammalian aging and the design of interventions to repair and/or obviate that damage. He has developed a possibly comprehensive plan for such repair, termed Strategies for Engineered Negligible Senescence (SENS), which breaks aging down into seven major classes of damage and identifies detailed approaches to addressing each one. A key aspect of SENS is that it can potentially extend healthy lifespan without limit, even though these repair processes will probably never be perfect, as the repair only needs to approach perfection rapidly enough to keep the overall level of damage below pathogenic levels. Dr. de Grey has termed this required rate of improvement of repair therapies “longevity escape velocity”. Dr. de Grey is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organisations. Tel.: +44 1223 366197 or +1 650 938 6100 Email: [email protected] Date of birth: 20th April, 1963 Nationality: British Marital status: Married to Dr. Adelaide T.C. Carpenter; no children Education: B.A. (1985), M.A. (1988) and Ph.D. (2000), University of Cambridge, Cambridge, UK Past employment: 1985-1986: Sinclair Research, Cambridge, UK 1986-1992: Man-Made Minions, Cambridge, UK 1992 (Jan-Oct): EO Computer, Cambridge, UK 1992-2006: Department of Genetics, University of Cambridge, Cambridge, UK 2003-2009: Chairman and Chief Science Officer, Methuselah Foundation Honours: 2 2003: Gerontological Society of America: Fellow 2004: World Transhumanist Association: H.G. Wells Award 2005: American Aging Association: Fellow

Society memberships: American Aging Association (member of board of directors, 2002-2007 and 2010-present) International Association of Biomedical Gerontology (chair, 2003-2005) British Society for Research on Ageing (member of board of directors, 2003-2006) Gerontological Society of America International Coenzyme Q10 Association Mitochondrion Research Society

Scientific advisory boards (unpaid): Maximum Life Foundation Legendary Pharmaceuticals Centenarian Species and Rockfish Project Alcor Life Extension Foundation Singularity Institute for Artificial Intelligence Foresight Institute Biomind Lifeboat Foundation Humanity+ Campaign for Aging Research

Conferences organised: Euromit 4, Cambridge, UK, September 1999 (co-organiser) Strategies for Engineered Negligible Senescence, 1st roundtable, Oakland, CA, USA, October 2000 Strategies for Engineered Negligible Senescence, 2nd roundtable, Los Angeles, CA, USA, Aug. 2001 Strategies for Engineered Negligible Senescence, 3rd roundtable, Cambridge, UK, December 2002 International Association of Biomedical Gerontology, 10th Congress, Cambridge, UK, Sept. 2003 Strategies for Engineered Negligible Senescence, 4th roundtable, Bethesda, MD, USA, July 2004 Strategies for Engineered Negligible Senescence, 2nd conference, Cambridge, UK, September 2005 Strategies for Engineered Negligible Senescence, 3rd conference, Cambridge, UK, September 2007 Understanding Aging: Biomedical and Bioenginering Approaches, Los Angeles, USA, June 2008 Strategies for Engineered Negligible Senescence, 4th conference, Cambridge, UK, September 2009 3 Strategies for Engineered Negligible Senescence, 5th conference, Cambridge, UK, September 2011 Strategies for Engineered Negligible Senescence, 6th conference, Cambridge, UK, September 2013

Journal editorial board memberships: Rejuvenation Research (editor-in-chief) Disruptive Science and Technology (executive editor) Mitochondrion (associate editor) AGE – Journal of the American Aging Association Current Stem Cell Research & Therapy Current Gerontology and Geriatrics Research

Publications: - Articles in peer-reviewed journals: de Grey ADNJ. A proposed refinement of the mitochondrial free radical theory of aging. BioEssays 1997; 19(2):161-166. de Grey ADNJ. A mechanism proposed to explain the rise in oxidative stress during aging. J Anti- Aging Med 1998; 1(1):53-66. de Grey ADNJ. Incorporation of transmembrane hydroxide transport into the chemiosmotic theory. Bioelectrochem Bioenerg 1999; 49(1-2):43-50. de Grey ADNJ. The non-correlation between maximum longevity and enzymatic antioxidant levels among homeotherms; implications for retarding human aging. J Anti-Aging Med 2000; 3(1):25-36. de Grey ADNJ. The reductive hotspot hypothesis: an update. Arch Biochem Biophys 2000; 373(1):295-301. de Grey ADNJ. Mitochondrial gene therapy: an arena for the biomedical use of inteins. Trends Biotechnol 2000; 18(9):394-399. de Grey ADNJ. A proposed mechanism for the lowering of mitochondrial electron leak by caloric restriction. Mitochondrion 2001; 1(2):129-139. de Grey ADNJ. UK research on the biology of aging. Exp Gerontol 2001; 37(1):1-7. de Grey ADNJ, Ames BN, Andersen JK, Bartke A, Campisi J, Heward CB, McCarter RJM, Stock G. Time to talk SENS: critiquing the immutability of human aging. Annals NY Acad Sci 2002; 959:452-462. de Grey ADNJ. The reductive hotspot hypothesis of mammalian aging: membrane metabolism magnifies mutant mitochondrial mischief. Eur J Biochem 2002; 269(8):2003-2009. de Grey ADNJ. HO2: the forgotten radical. DNA Cell Biol 2002; 21(4):251-257. de Grey ADNJ, Baynes JW, Berd D, Heward CB, Pawelec G, Stock G. Is human aging still mysterious enough to be left only to scientists? BioEssays 2002; 24(7):667-676. de Grey ADNJ. Bioremediation meets biomedicine: therapeutic translation of microbial catabolism to the lysosome. Trends Biotechnol 2002; 20(11):452-455. 4 de Grey ADNJ. An engineer’s approach to the development of real anti-aging medicine. Science’s SAGE KE 2003; 2003(1):vp1. de Grey ADNJ. Challenging but essential targets for genuine anti-ageing drugs. Expert Opin Therap Targets 2003; 7(1):1-5. de Grey ADNJ. Critique of the demographic evidence for “late-life non-senescence”. Biochem Soc Trans 2003; 31(2):452-454. de Grey ADNJ. UK research on the biology of aging – the next ten years. Lifespan 2003; 11(1):1-4. de Grey ADNJ. A hypothesis for the minimal overall structure of the mammalian plasma membrane redox system. Protoplasma 2003; 221(1-2):3-9. de Grey ADNJ. The foreseeability of real anti-aging medicine: focusing the debate. Exp Gerontol 2003; 38(9):927-934. de Grey ADNJ. Falsifying falsifications: the most critical task of theoreticians in biology. Med Hypoth 2004; 62(6):1012-1020. de Grey ADNJ. Escape velocity: why the prospect of extreme human life extension matters now. PLoS Biol 2004; 2(6):723-726. de Grey ADNJ, Campbell FC, Dokal I, Fairbairn LJ, Graham GJ, Jahoda CAB, Porter ACG. Total deletion of in vivo telomere elongation capacity: an ambitious but possibly ultimate cure for all age-related human cancers. Annals NY Acad Sci 2004; 1019:147-170. de Grey ADNJ. Biogerontologists’ duty to discuss timescales publicly. Annals NY Acad Sci 2004; 1019:542-545. de Grey ADNJ. Inter-species therapeutic cloning: the looming problem of mitochondrial DNA and two possible solutions. Rejuvenation Res 2004; 7(2):95-98. de Grey ADNJ. The unfortunate influence of the weather on the rate of aging: why human caloric restriction or its emulation may only extend life expectancy by 2-3 years. Gerontology 2005; 51(2):73-82. de Grey ADNJ. Forces maintaining organellar genomes: is any as strong as genetic code disparity or hydrophobicity? BioEssays 2005; 27(4):436-446. de Grey ADNJ. Whole-body interdiction of lengthening of telomeres: a proposal for cancer prevention. Front Biosci 2005; 10:2420-2429. de Grey ADNJ. Reactive oxygen species production in the mitochondrial matrix: implications for the mechanism of mitochondrial mutation accumulation. Rejuvenation Res 2005; 8(1):13-17. de Grey ADNJ. Resistance to debate on how to postpone ageing is delaying progress and costing lives. EMBO Rep 2005; 6(S1):S49-S53. de Grey ADNJ, Alvarez PJJ, Brady RO, Cuervo AM, Jerome WG, McCarty PL, Nixon RA, Rittmann BE, Sparrow JR. Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases. Ageing Res Rev 2005; 4(3):315-338. de Grey ADNJ. Life extension, human rights, and the rational refinement of repugnance. J Med Ethics 2005; 31(11):659-663. de Grey ADNJ. A strategy for postponing aging indefinitely. Stud Health Technol Inform 2005; 118:209-219. de Grey ADNJ. The plasma membrane redox system: a candidate source of aging-related oxidative stress. AGE J Am Aging Assoc 2005; 27(2):129-138. 5 de Grey ADNJ. Appropriating microbial catabolism: a proposal to treat and prevent neurodegeneration. Neurobiol Aging 2006; 27(4):589-595. de Grey ADNJ. Extrapolaholics Anonymous: why demographers’ rejections of a huge rise in cohort life expectancy in this century are overconfident. Annals NY Acad Sci 2006; 1067:83-93. de Grey ADNJ. Foreseeable pharmaceutical repair of age-related extracellular damage. Curr Drug Targets 2006; 7(11):1469-1477. de Grey ADNJ. Free radicals in aging: causal complexity and its biomedical implications. Free Radic Res 2006; 40(12):1244-1249. de Grey ADNJ. The urgency dilemma: is life extension research a temptation or a test? Update 2006; 21(1):6-10. de Grey ADNJ. The natural biogerontology portfolio: “defeating aging” as a multi-stage ultra-Grand Challenge. Annals NY Acad Sci 2007; 1100:409-423. de Grey ADNJ. Protagonistic pleiotropy: why cancer may be the only pathogenic effect of accumulating nuclear mutations and epimutations in aging. Mech Ageing Dev 2007; 128(7- 8):456-459. Phoenix CR, de Grey ADNJ. A model of aging as accumulated damage matches observed mortality patterns and predicts the life-extending effects of prospective interventions. AGE 2007; 29(4):133-189. de Grey ADNJ. Calorie restriction, post-reproductive lifespan and programmed aging: a plea for rigour. Annals NY Acad Sci 2007; 1119:296-305. de Grey ADNJ. Alzheimer’s, atherosclerosis, and aggregates: A role for bacterial degradation. Nutr Rev 2007; 65(12 Pt. 2):S221-S227. de Grey ADNJ. Life span extension research and public debate: societal considerations. Studies in Ethics, Law and Technology 2007; 1(1):5. de Grey ADNJ. Our right to life. J Evol Technol 2008; 17(2):53-57. de Grey ADNJ. The singularity and the Methuselarity: similarities and differences. Stud Health Technol Inform 2009; 149:195-202. de Grey ADNJ. Making sure that health and wealth keep pace with extended life expectancy. United Academics Magazine 2012; 2012(April/May): http://www.united- academics.org/magazine/17748/making-sure-that-health-and-wealth-keep-pace-with-extended- life-expectancy/ de Grey ADNJ. Zeno’s paradox and the faith that technological game-changers are impossible. Gerontology 2012, in press. Zealley BJ, de Grey ADNJ. Strategies for engineered negligible senescence (SENS). Gerontology 2012, in press.

- Reviews and commentaries: de Grey ADNJ. More on mitochondria and senescence: Response to Gershon. BioEssays 1997; 19(6):534-534. de Grey ADNJ. Review of Cadenas E and Packer L (eds), “Understanding the Process of Aging: The Roles of Mitochondria, Free Radicals, and Antioxidants”. J Anti-Aging Med 1999; 2(3):291. 6 de Grey ADNJ. Review of Harman D, Holliday R and Meydani M (eds), “Towards Prolongation of the Healthy Life Span: Practical Approaches to Intervention”. J Anti-Aging Med 1999; 2(3):292. de Grey ADNJ. Popular gerontology comes of age. Review of Kirkwood TBL, “Time of our Lives”. BioEssays 1999; 21(9):802-803. de Grey ADNJ. Biologists abandon Popper at their peril. BioEssays 2000; 22(2):206-207. de Grey ADNJ. The function of mitochondrial dysfunction in aging. J Anti-Aging Med 2000; 3(1):109-112. de Grey ADNJ. Review of Asard H, Berczi A and Caubergs RJ (eds), “Plasma Membrane Redox Systems and Their Role in Biological Stress and Disease”. Antioxid Redox Signal 2000; 2(2):371-372. de Grey ADNJ. Redox 2000: the 5th international conference on plasma membrane redox systems and their role in biological stress and disease. Antioxid Redox Signal 2000; 2(2):373-374. de Grey ADNJ. Review of Scheffler I, “Mitochondria”. J Am Aging Assoc 2000; 23(4):255. de Grey ADNJ. Antioxidants and redox signaling: Internet resources. Antioxid Redox Signal 2000; 2(4):937-940. de Grey ADNJ. Gerontologists and the media: the dangers of over-pessimism. Biogerontology 2000; 1(4):369-370. de Grey ADNJ. Review of Wickens A, “The Causes of Aging”. Exp Gerontol 2000; 34(8):1017-1018. de Grey ADNJ. Response to “telomere shortening with aging in human liver”. J Gerontol A Biol Sci Med Sci 2001; 56(6):B237-B238. de Grey ADNJ. Response to “approaches and limitations to gene therapy for mitochondrial diseases,” Antioxid. Redox Signal. 2001;3:451-460. Antioxid Redox Signal 2001; 3(6):1153-1155. de Grey ADNJ. Review of Finch CE and Kirkwood TBL, “Chance, development, and aging”. Exp Gerontol 2001; 36(10):1783-1785. de Grey ADNJ. Nature of the aging process - Open discussion. Annals NY Acad Sci 2002; 959:463- 465. de Grey ADNJ, Gavrilov L, Olshansky SJ, Coles LS, Cutler RG, Fossel M, Harman SM. Antiaging technology and pseudoscience. Science 2002; 296(5568):656. de Grey ADNJ. Three detailed hypotheses implicating oxidative damage to mitochondria as a major driving force in homeotherm aging. Eur J Biochem 2002; 269(8):1995. de Grey ADNJ. Review of Nicholls DG and Ferguson SJ, “Bioenergetics 3”. Mitochondrion 2002; 2(3):211-213. de Grey ADNJ. Fear of misrepresentation cannot justify silence about foreseeable life-extension biotechnology. BioEssays 2003; 25(1):94-95. de Grey ADNJ. Overzealous maximum-likelihood fitting falsely convicts the slope heterogeneity hypothesis. Exp Gerontol 2003; 38(8):921-923. de Grey ADNJ. Review of Mattson MP and Van Zant G (eds), “Stem Cells: A Cellular Fountain of Youth”. Exp Gerontol 2003; 38(9):1025-1026. de Grey ADNJ. Breathtaking biomedical blind spots. Review of Guarente L, “Ageless Quest”. BioEssays 2004; 26(1):108-109. 7 de Grey ADNJ. Models on trial: falsifying overstated claims of generality does not falsify correctly- stated ones. Exp Gerontol 2004; 39(3):453. de Grey ADNJ. Mitochondria in homeotherm aging: will detailed mechanisms consistent with the evidence now receive attention? Aging Cell 2004; 3(2):77. de Grey ADNJ. Report of open discussion on the future of life extension research. Annals NY Acad Sci 2004; 1019:552-553. de Grey ADNJ. Welcome to Rejuvenation Research. Rejuvenation Res 2004; 7(1):1-2. de Grey ADNJ. Leon Kass: quite substantially right. Rejuvenation Res 2004; 7(2):89-91. de Grey ADNJ. Three self-evident life-extension truths. Rejuvenation Res 2004; 7(3):165-167. de Grey ADNJ. Mitochondrial mutations in mammalian aging: an over-hasty about-turn? Rejuvenation Res 2004; 7(3):171-174. de Grey ADNJ. Meeting report: Regenerate 2004: tissue engineering the human body, June 10-12, 2004, Seattle. Rejuvenation Res 2004; 7(3):226-228. de Grey ADNJ. Aging, childlessness, or overpopulation: the future’s right to choose. Rejuvenation Res 2004; 7(4):237-238. de Grey ADNJ. Meeting report: 8th International Symposium on the Maillard Reaction. Charleston, South Carolina, August 28-September 1 2004. Rejuvenation Res 2004; 7(4):257-260. de Grey ADNJ. When and where to publish important findings: a casualty of biogerontology’s rise to respectability. Rejuvenation Res 2005; 8(1):1-2. de Grey ADNJ. “The rate of aging”: a counterproductively undefinable term. Rejuvenation Res 2005; 8(2):77-78. de Grey ADNJ. The ethical status of efforts to postpone aging: a reply to Hurlbut. Rejuvenation Res 2005; 8(3):129-130. de Grey ADNJ. The SENS Challenge: $20,000 says the foreseeable defeat of aging is not laughable. Rejuvenation Res 2005; 8(4):207-210. de Grey ADNJ. Meeting report: International Association of Biomedical Gerontology, 11th Congress, 13th-16th August, 2005, Aarhus, Denmark. Rejuvenation Res 2005; 8(4):264-266. de Grey ADNJ. Like it or not, life extension research extends beyond biogerontology. EMBO Reports 2005; 6(11):1000. de Grey ADNJ. Compression of morbidity: the hype and the reality, part 1. Rejuvenation Res 2006; 9(1):1-2. de Grey ADNJ. Compression of morbidity: the hype and the reality, part 2. Rejuvenation Res 2006; 9(2):167-168. de Grey ADNJ. Has Hippocrates had his day? Rejuvenation Res 2006; 9(3):371-373. de Grey ADNJ. SENS survives the Challenge; now let’s get to work. Rejuvenation Res 2006; 9(4):429-430. de Grey ADNJ. Is SENS a farrago? Rejuvenation Res 2006; 9(4):436-439. de Grey ADNJ. SENS is hard, yes, but not too hard to try: a reply to Warner. Rejuvenation Res 2006; 9(4):443-445. de Grey ADNJ. Aging and airborne HIV: a reassuring analogy. Rejuvenation Res 2007; 10(1):1-3. 8 de Grey ADNJ. New developments at Rejuvenation Research: high impact factor, advance online publication and more. Rejuvenation Res 2007; 10(2):125-126. de Grey ADNJ. The case for prioritising research on late-onset life-extension interventions in mammals. Rejuvenation Res 2007; 10(3):257-259. de Grey ADNJ. Edmonton: a future center for pioneering biomedical gerontology? Rejuvenation Res 2007; 10(3):345-347. de Grey ADNJ. The need to debalkanize gerontology: a case study. Rejuvenation Res 2007; 10(4):431- 434. de Grey ADNJ. Understanding and tackling aging: two fields communicating (a little) at last. Rejuvenation Res 2007; 10(4):637-640. de Grey ADNJ. Old people are people too: why it is our duty to fight aging to the death. Cato Unbound 2007(12): lead essay. de Grey ADNJ. Curiosity is addictive, and this is not necessarily a good thing. Rejuvenation Res 2008; 11(1):1-3. de Grey ADNJ. Man, machines, manufacturing and maintenance: merits of a much-maligned metaphor. Rejuvenation Res 2008; 11(2):277-279. de Grey ADNJ. Long live the unreasonable man. Rejuvenation Res 2008; 11(3):541-542. de Grey ADNJ. Combating the Tithonus Error: what works? Rejuvenation Res 2008; 11(4):713-715. de Grey ADNJ. Trans-simianism and truthiness: hints of progress in the debate on whether aging is good. Rejuvenation Res 2008; 11(5):857-859. de Grey ADNJ. Estimating rates of future biomedical progress: a reply to Bains. Biosci Hyp 2008; 1(5):286. de Grey ADNJ. Aging: a foreseeable target of stem cells and regenerative medicine. World Stem Cell Report 2008:17-19. de Grey ADNJ. Cautionary tales of the unexpected. Rejuvenation Res 2008; 11(6):989-990. de Grey ADNJ. Consolidating the mission to defeat aging: a big step forward. Rejuvenation Res 2008; 11(6):1061-1063. de Grey ADNJ. Cracks in social gerontology’s pro-aging edifice. Rejuvenation Res 2009; 12(1):1-3. de Grey ADNJ. The curiously misunderstood role of evidence in designing new technology. Rejuvenation Res 2009; 12(2):75-76. de Grey ADNJ. Why are so many people so unashamedly selfish about the prospect of combating aging? Rejuvenation Res 2009; 12(3):165-167. de Grey ADNJ. How is mutant mitochondrial DNA clonally amplified? Much new evidence, still no answers. Rejuvenation Res 2009; 12(3):217-219. de Grey ADNJ. Persons of tenure: less fortunate than they may seem. Rejuvenation Res 2009; 12(4):237-238. de Grey ADNJ. Aging: can piecemeal preventative maintenance work? World Stem Cell Report 2009:101-103. de Grey ADNJ. The Einsteinian imperative. Rejuvenation Res 2009; 12(6):383-385. de Grey ADNJ. Hype and anti-hype in academic biogerontology research. Rejuvenation Res 2010; 13(2-3):137-138. 9 Rae MJ, Butler RN, Campisi J, de Grey ADNJ, Finch CE, Gough M, Martin GM, Vijg J, Perrott KM, Logan BJ. The demographic and biomedical case for late-life interventions in aging. Sci Transl Med 2010;2(40):40cm21. de Grey ADNJ. Reaping the longevity dividend in time: biogerontology heavyweights advocate seeking late-onset interventions against aging. Rejuvenation Res 2010;13(4):383-385. de Grey ADNJ. Biology: a field in need of a community culture. Rejuvenation Res 2010;13(5):507- 508. de Grey ADNJ. European Council of Art: a new initiative to combine both fields and cultures in the pursuit of visionary goals.Rejuvenation Res 2010;13(6):629-630. de Grey ADNJ. Premature deaths close to home. Rejuvenation Res 2011;14(1):1-2. de Grey ADNJ. Silver linings of oversimplification. Rejuvenation Res 2011;14(2):109-110. de Grey ADNJ. The evolution of dogma. Rejuvenation Res 2011;14(3):239-240. de Grey ADNJ. Progress... but speed is of the essence. Rejuvenation Res 2011;14(4):351-352. de Grey ADNJ. When in doubt, maximize your options. Rejuvenation Res 2011;14(5):467-468. de Grey ADNJ. The many-level value of proofs of concept. Rejuvenation Res 2012;15(2):121-122. Zealley BJ, de Grey ADNJ. Cancers co-opt cohabitants' catabolism: Autophagy and senescence in the tumor stroma. Cell Cycle 2012;11(12):2230. de Grey ADNJ. Biological versus medical limits on aging: a distinction we must not elide. Rejuvenation Res 2012;15(3):255-256. de Grey ADNJ. What's really delaying the defeat of aging? Rejuvenation Res 2012;15(4):347-348. de Grey ADNJ. The future dominance of combination therapies: implications for today's medical research. Rejuvenation Res 2012;15(5):443-444. de Grey ADNJ. Dilemmas of discussing dramatic developments. Rejuvenation Res 2012;15(6):543- 544.

- Books: de Grey ADNJ. The mitochondrial free radical theory of aging. Austin, TX: Landes Bioscience, 1999, 212pp, hardcover (ISBN 1-57059-564-X). de Grey ADNJ, Rae M. Ending Aging: The rejuvenation biotechnologies that could reverse human aging in our lifetime. New York, NY: St. Martin’s Press, 2007, 416pp, hardcover (ISBN 0-312- 36706-6). Paperback edition: St. Martin’s Press, 2008, 448pp (ISBN 0-312-36707-4).

- Book chapters: de Grey ADNJ. Are those 13 proteins really unimportable? In: From Symbiosis to Eukaryotism - Endocytobiology VII (E. Wagner et al., eds.), Geneva University Press, 1999, pp. 489-502. de Grey ADNJ. Mitochondrial mutations in vertebrate aging. In: Oxidative stress and aging: advances in basic science, diagnostics, and intervention (R.G. Cutler and H. Rodriguez, eds.), World Scientific Publishing, 2002, pp. 437-451. 10 de Grey ADNJ. Mechanisms underlying the age-related accumulation of mutant mitochondrial DNA. In: Genetics of mitochondrial diseases (I.J. Holt, ed.), Oxford University Press, 2003, pp. 247- 275. de Grey ADNJ. An engineer’s approach to the development of real anti-aging medicine. In: The Fountain of Youth: Ethical, Religious, and Existential Perspectives on a Biomedical Goal (S.G. Post and R.H. Binstock, eds.), Oxford University Press, 2004, pp. 249-267. de Grey ADNJ. The war on aging. In: The Scientific Conquest of Death (B.J. Klein et al., eds.), Libros en Red, 2004, pp. 17-29. de Grey ADNJ. Foreseeable and more distant rejuvenation therapies. In: Aging Interventions and Therapies (S.I.S. Rattan, ed.), World Scientific, 2005, pp. 379-395. de Grey ADNJ. The foreseeability of real anti-aging medicine. In: Anti-Aging Medical Therapeutics, volume 7 (R. Klatz, ed.), American Academy for Anti-Aging Medicine, 2005, pp. 59-68. de Grey ADNJ. Lysosomal enhancement with microbial hydrolases: a novel strategy for removing protein aggregates. In: New Trends in Alzheimer and Parkinson Disorders: ADPD 2005 (A. Fisher et al., eds.), Medimond, 2005, pp. 51-54. de Grey ADNJ. Gene therapy. In: Encyclopedia of Aging, 4th Edition (R. Schulz et al., eds.), Springer, 2006, pp. 439-443. de Grey ADNJ. Strategie per un invecchiamento transcurabile ingegnerizzato. In: Alterando il destino dell’umanità (P. Donghi, ed.), Proceedings of the 2005 Spoletoscienza conference, Laterza & Figli, 2006, pp. 49-63. de Grey ADNJ. Defeat of aging - utopia or foreseeable scientific reality? In: The Future of Life and the Future of our Civilization (V. Burdyuzha, ed.), Springer, 2006, pp. 277-290. de Grey ADNJ. Rejuvenating neurons and glia with microbial enzymes. In: Interaction Between Neurons and Glia in Aging and Disease (J.O. Malva et al., eds.), Springer, 2007, pp. 503-510. de Grey ADNJ. Endless Youth. In: Eindeloos, 22ste Almanak der Groningse Farmaceutische Studenten Vereniging “Pharmaciae Sacrum” (I. Dubbelboer et al., eds.), 2008, pp. 22-27. de Grey ADNJ. Postponing aging: re-identifying the experts? In: Unnatural Selection: the Challenges of Engineering Tomorrow’s People (P. Healey and S. Rayner, eds.), 2008, pp. 89-94. de Grey ADNJ. Radical life extension: technological aspects. In: Religion and the Implications Of Radical Life Extension (D.F. Maher and C. Mercer, eds.), Palgrave Macmillan, 2009, pp. 13- 24. de Grey ADNJ. WILT: necessity, feasibility, affordability. In: The Future of Aging: Pathways to Human Life Extension (G. Fahy et al., eds.), Springer, 2010, pp. 667-685. de Grey ADNJ. Physical resilience and aging: correcting the Tithonus error and the crème brulée error. In: New Frontiers of Resilient Aging: Life-Strengths and Well-Being in Late Life (P.S. Fry and C.L.M. Keyes, eds.), 2010, pp. 90-103. de Grey ADNJ. Prospects for the biomedical postponement of aging: technical context for a theological debate. In: The Routledge Companion to Religion and Science (J.W. Haag, G.R. Peterson and M.L. Spezio, eds.), 2011, pp. 531-539. de Grey ADNJ. Living to 100 and maybe much longer: the engineering and biotechnology of life- extension medicine and when it may arrive. In: Proceedings of the 6th International Conference on Intelligent Processing and Manufacturing of Materials, (J.A. Meech, ed.), 2012, in press. de Grey ADNJ. Is the quest to defeat aging ethical? In: Ethical Futures (S. Wint, ed.), 2012, in press. 11 de Grey ADNJ. Consciousness in the context of radical life extension. In: Holistic Consciousness: Cognition, Memory, Individuality, Free Will, Zombies, Life, Death, Immortality and the Immune System (N. Bauer, ed.), 2012, in press. de Grey ADNJ. The future of regenerative medicine: the undoing of ageing. In: A Manual of Current Therapies in Regenerative Medicine (J.-T. Schantz, ed.), 2012, in press.

Invitations to speak: - Seminars: University of Indiana, Bloomington, IN, USA, April 1997 University of California, Riverside, CA, USA, February 1998 University of Newcastle, UK, October 1998 University of Linköping, Sweden, May 1999 University of Marburg, Germany, July 1999 ETH (Eidgenössische Technische Hochschule), Zurich, Switzerland, September 1999 MRC Laboratory of Molecular Biology, Cambridge, UK, November 1999 MRC Dunn Human Nutrition Unit, Cambridge, UK, January 2000 University of Washington, Seattle, WA, USA, June 2000 University of California, Irvine, CA, USA, October 2000 University of California, Los Angeles, CA, USA, October 2000 University of Southern California, Los Angeles, CA, USA, October 2000 Kronos Longevity Research Institute, Phoenix, AZ, USA, February 2002 University of Southampton, UK, April 2002 Gray Cancer Institute, Northwood, UK, September 2002 University of Newcastle, UK, February 2003 University of California, Santa Barbara, CA, USA, March 2003 Unilever Research and Development, Colworth, UK, April 2004 University of Tampere, Finland, May 2004 ExtroBritannia, Wolverton, UK, July 2004 CCLRC Daresbury Laboratory, Warrington, UK, October 2004 University of Birmingham, UK, November 2004 University of Calgary, Calgary, AB, Canada, February 2005 University of Alberta, Edmonton, AB, Canada, February 2005 Baylor College of Medicine, Houston, TX, USA, March 2005 Rice University, Houston, TX, USA, March 2005 University of Texas Health Sciences Center, San Antonio, TX, USA, March 2005 Café Scientifique, Edinburgh, UK, April 2005 12 Hunter College, New York, NY, USA, April 2005 Stanford University, Stanford, CA, USA, June 2005 (two talks) University of Utrecht, Utrecht, The Netherlands, September 2005 London Regenerative Medicine Network, University College, London, UK, October 2005 University of Cambridge Institute of Biotechnology, Cambridge, UK, December 2005 Kronos Longevity Research Institute, Phoenix, AZ, USA, December 2005 People Unlimited, Scottsdale, AZ, USA, December 2005 Loma Linda University, Loma Linda, CA, USA, February 2006 Faith, Reason and Community Forum, Loma Linda, CA, USA, February 2006 Knutsford SciBAr, Knutsford, UK, February 2006 Demos, London, UK, February 2006 Sierra Sciences, Reno, NV, USA, February 2006 Corven Corporate Finance, London, UK, March 2006 University of Cambridge Medical Society, Cambridge, UK, March 2006 University of Arizona, Tucson, AZ, USA, April 2006 Arizona State University Biodesign Institute, Tempe, AZ, USA, April 2006 Yale University, New Haven, CT, USA, May 2006 Junto, New York, NY, USA, June 2006 BUPA, London, UK, September 2006 University of Michigan, Ann Arbor, MI, USA, October 2006 ExtroBritannia, London, UK, October 2006 The Pensions Net Work, Maidstone, UK, December 2006 University of Heidelberg, Heidelberg, Germany, January 2007 Cambridge University Student Pugwash Society, Cambridge, UK, February 2007 Buck Institute for Age Research, Novato, CA, USA, March 2007 University of Hohenheim, Stuttgart, Germany, April 2007 Google, Mountain View, CA, USA, May 2007 Royal Society of Arts, London, UK, June 2007 Google, Mountain View, CA, USA, June 2007 San Francisco Future Salon, Palo Alto, CA, USA, July 2007 Cambridge Hi-tech Association of Small Enterprises, Cambridge, UK, August 2007 British Humanist Association, London, UK, August 2007 University of California Berkeley, Berkeley, CA, USA, October 2007 Oxford University Science Society, Oxford, UK, October 2007 Sangamo Sciences, Richmond, CA, USA, October 2007 13 Milner Society (Queens’ College Cambridge), Cambridge, UK, November 2007 Case Western Reserve University, Cleveland, OH, USA, November 2007 (two talks) Royal College of Arts, London, UK, November 2007 Google, Mountain View, CA, USA, December 2007 Bangor SciBAr, Bangor, UK, January 2008 Dana Centre, London, UK, January 2008 Trinity College Science Society, Cambridge, UK, January 2008 University of Pennsylvania, Philadelphia, PA, February 2008 New York University, New York, NY, USA, February 2008 Cass Business School, London, UK, February 2008 Cambridge Young Solicitors and Professionals Group, Cambridge, UK, February 2008 St Paul’s School, London, UK, March 2008 Spirit of the Senses, Phoenix, AZ, USA, March 2008 University of Wisconsin, Madison, WI, USA, April 2008 Orlando Science Center, Orlando, FL, USA, May 2008 Proctor & Gamble workshop “Future thinking”, New York, NY, USA, June 2008 University of Alberta, Edmonton, Canada, June 2008 The Pensions Net Work, Hurley, UK, June 2008 Toronto Public Library Network, Toronto, Canada, June 2008 ExtroBritannia, London, UK, July 2008 University of Hull, Hull, UK, July 2008 Café Scientifique, Lichfield, UK, July 2008 The Motley Fool, Alexandria, MD, USA, July 2008 Google, New York, NY, USA, July 2008 UCLA student group “POLIS”, Los Angeles, CA, USA, August 2008 NuSkin, Provo, UT, USA, August 2008 NASA Ames Research Center, Mountain View, CA, UA, August 2008 Think Tank der Bank Sarasin & Cie, Zurich, Switzerland, September 2008 Kronos Longevity Research Institute, Scottsdale, AZ, USA, September 2008 University of Ghent, Ghent, Belgium, October 2008 Jewish Community Center of San Francisco, San Francisco, CA, USA, October 2008 Stanford Transhumanist Association, Palo Alto, CA, USA, October 2008 The Nature Debate, London, UK, November 2008 Spirit of the Senses, Phoenix, AZ, USA, December 2008 HEALES, Narbonne, France, January 2009 14 Caixa Foundation, Lleida, Spain, January 2009 Caixa Foundation, Barcelona, Spain, January 2009 Caixa Foundation, Madrid, Spain, January 2009 University of Palma, Palma, Mallorca, January 2009 Caixa Foundation, Tarragona, Spain, January 2009 Kent State University, Kent, OH, USA, February 2009 University of Manchester, Manchester, UK, February 2009 University of Liverpool, Liverpool, UK, February 2009 Moscow State University, Moscow, Russia, March 2009 University of Westminster, London, UK, March 2009 University of Ghent, Ghent, Belgium, March 2009 Bank Sarasin & Cie, Interlaken, Switzerland, April 2009 Queen Mary University of London, London, UK, April 2009 Smart Life Forum, Palo Alto, CA, USA, May 2009 Commonwealth Club, San Francisco, CA, USA, May 2009 University of Leicester, Leicester, UK, June 2009 Singularity University, Mountain View, CA, USA, July 2009 Summer Science Program, Ojai, CA, USA, July 2009 Skeptics in the Pub, London, UK, August 2009 Kings Fund, London, UK, September 2009 New York Academy of Sciences, New York, NY, USA, September 2009 Silicon Valley Transhumanist Meetup, Palo Alto, CA, USA, September 2009 The Commonwealth Medical College, Scranton, PA, USA, September 2009 UK Transhumanist Association, London, UK, October 2009 Oxford University Science Society, Oxford, UK, October 2009 Karolinska Institute, Stockholm, Sweden, October 2009 (two talks) Osher Lifelong Learning Institute, Saginaw, MI, USA, November 2009 NHS Workforce Review Team, Winchester, UK, December 2009 Haberdashers’ Aske’s Boys’ School, Elstree, UK, January 2010 Wellcome Trust, London, UK, January 2010 Staffordshire University, Stafford, UK, March 2010 Omega Institute, Rhinebeck, NY, USA, October 2010

- National and international meetings: 15 Endocytobiology VII, Freiburg, Germany, April 1998 4th European Congress of Gerontology, Berlin, Germany, July 1999 Euromit 4, Cambridge, UK, September 1999 Symposium: stress and ageing in animals and microorganisms, Porto, Portugal, June 2000 BBSRC Science of Ageing symposium, Manchester, UK, January 2001 O2SA (Oxidative Stress in Aging), 2nd Conference, Maui, HI, USA, April 2001 International Association of Biomedical Gerontology, 9th Congress, Vancouver, Canada, June 2001 27th Meeting of FEBS, Lisbon, Portugal, July 2001 Warburg Society, inaugural conference, Point Clear, LA, USA, October 2001 6th International Conference on Plasma Membrane Redox Systems, Ravenna, Italy, March 2002 Mechanisms of Caloric Restriction conference, Bandera, TX, USA, October 2002 3rd European Congress of Biogerontology pre-meeting, San Miniato, Italy, November 2002 5th Alcor Conference on Extreme Life Extension, Newport Beach, CA, USA, November 2002 Foresight Institute 2003 Senior Associates Gathering, Palo Alto, CA, USA, May 2003 Transvision 2003, Yale University, New Haven, CT, USA, June 2003 CMIB symposium “Projecting Future Mortality”, Edinburgh, UK, October 2003 Pop!Tech 2003 conference “Sea Change”, Camden, ME, USA, October 2003 7th International Conference on Plasma Membrane Redox Systems, Asilomar, CA, USA, April 2004 Pittsburgh symposium “Frontiers in Human Embryonic Stem Cells”, Pittsburgh, PA, USA, May 2004 3rd Medical and Aesthetic Procedures Meeting, Barcelona, Spain, June 2004 3rd Asia Pacific Conference and Exhibition on Anti-Ageing Medicine, Singapore, June 2004 Transvision 2004, Toronto, Canada, August 2004 1st Anti-Ageing Conference London, London, UK, September 2004 German Society of Gerontology and Geriatrics, 7th Congress, Hamburg, Germany, October 2004 5th Neurobiology of Aging symposium, San Diego, CA, USA, October 2004 Integrative Medical Therapeutics for Anti-Aging conference, Las Vegas, NV, USA, October 2004 EMBL/EMBO conference on Science and Society, Heidelberg, Germany, November 2004 Futurshow 3004, Milan, Italy, November 2004 12th Annual World Congress on Anti-Aging Medicine, Las Vegas, NV, USA, December 2004 BIOMEDEX 2005, Montreal, Canada, March 2005 IHEU-Appignani Humanist Center for Bioethics, 1st Conference, New York, NY, USA, April 2005 2nd “The future of life and the future of our civilization” symposium, Frankfurt, Germany, May 2005 2nd Anti-Ageing Conference London, London, UK, May 2005 Workshop on Models in the Biodemography of Aging, Berkeley, CA, USA, June 2005 FENS Summer School, Coimbra, Portugal, July 2005 16 TEDGLOBAL (Technology, Entertainment, Design) conference, Oxford, UK, July 2005 17th SpoletoScienza conference “Altering Human Destiny”, Spoleto, Italy, July 2005 Eris Society, 25th annual conference, Aspen, CO, USA, August 2005 International Association of Biomedical Gerontology, 11th Congress, Aarhus, Denmark, August 2005 10th Future of Health Technology Summit, Cambridge, MA, USA, September 2005 4th RNAO International Elder Care Conference, Toronto, Canada, September 2005 Conservative Party Conference 2005, Blackpool, UK, October 2005 Louis Vuitton Moet Hennessy symposium on mitochondria, Paris, France, October 2005 European Society for Cosmetic & Aesthetic Dermatology Society Mtg., London, UK, October 2005 Foresight Institute 2005 Vision Weekend, San Francisco, CA, USA, October 2005 Immortality Institute, 1st Conference, Atlanta, GA, USA, November 2005 58th Annual Meeting, Gerontological Society of America, Orlando, FL, USA, November 2005 Nordic Exceptional Trendshop 2005, Copenhagen, Denmark, November 2005 22nd Human Genetics Commission Plenary Meeting, November 2005 9th Goodenough conference ‘Age & Ageing: Just the Concern of the Old?’, London, UK, Dec. 2005 AAAS Annual Meeting, St. Louis, MO, USA, February 2006 TED (Technology, Entertainment, Design) 2006, Monterey, CA, USA, February 2006 Vodafone Foundation symposium, Madrid, Spain, March 2006 1st World Forum on Science and Civilisation, Oxford, UK, March 2006 1st Berkeley Stem Cell Retreat, Asilomar, CA, USA, March 2006 Calorie Restriction Society, 4th Conference, Tucson, AZ, USA, April 2006 Human Enhancement Technologies and Human Rights, Stanford, CA, USA, May 2006 Transvision 2006, Helsinki, Finland, August 2006 1st ENHANCE Workshop on the Extension of Lifespan, Cesano Maderno, Italy, September 2006 5th European Congress of Biogerontology, Istanbul, Turkey, September 2006 2nd Women’s Forum for the Economy and Society, Deauville, France, October 2006 6th Alcor Conference on Extreme Life Extension, Scottsdale, AZ, USA, October 2006 Living Well to 100, 2nd Conference, Boston, USA, November 2006 3rd World Mystery Forum, Interlaken, Switzerland, November 2006 American Academy of Religion, 2006 Annual Meeting, Washington, DC, USA, November 2006 Rome Science Festival, Rome, Italy, January 2007 London Technology Network: Stem Cells and Regenerative Medicine, London, UK, March 2007 Edmonton Aging Symposium, Edmonton, Canada, March 2007 UBS Global Investors’ Forum, London, UK, April 2007 German Society of Anti-Aging Medicine, 7th Conference, Munich, Germany, May 2007 17 2nd ENHANCE Workshop on the Extension of Lifespan, Cesano Maderno, Italy, May 2007 International Association of Biomedical Gerontology, 12th Congress, Spetses, Greece, May 2007 6th Cheltenham Science Festival, Cheltenham, UK, June 2007 6th Intl. Conf. on Intelligent Processing and Manufacturing of Materials, Salerno, Italy, June 2007 Oxford Conference on Genetics and Justice, Oxford, UK, July 2007 National Council for Palliative Care, 15th Anniversary Symposium, London, UK, July 2007 CEPS symposium “Europe facing ageing - economic perspectives”, Prague, Czech Rep., July 2007 Institute for Ethics and Emerging Technologies symposium, Chicago, IL, USA, July 2007 Transvision 2007, Chicago, IL, USA, July 2007 Secret Garden Party, Kings Ripton, UK, July 2007 4th Anti-Ageing Conference London, London, UK, September 2007 12th Future of Health and Technology Institute Conference, Cambridge, MA, USA, September 2007 Gadgetoff, New York, NY, USA, September 2007 7th Alcor Conference on Extreme Life Extension, Scottsdale, AZ, USA, October 2007 3rd European Anti-Aging Congress, Paris, France, October 2007 8th Asia/Oceania Regional Congress of Gerontology & Geriatrics, Beijing, China, October 2007 American Academy of Religion, 2007 Annual Meeting, San Diego, CA, USA, November 2007 Hewitt’s Local Government Pension Service symposium, London, UK, January 2008 Future of GI Health Summit, Boston, MA, USA, January 2008 BIL 2008, Monterey, CA, USA, March 2008 Center for Bioethics & Human Dignity, 1st Annual Phoenix Conf., Phoenix, AZ, USA, March 2008 Anti-Aging Medicine World Congress, Paris, France, April 2008 34th Asilomar Microcomputer Workshop, Asilomar, CA, USA, April 2008 Seoul Digital Forum, Seoul, Korea, May 2008 ERBI’s 10th Annual BioPartnering Exchange, Hinxton, UK, May 2008 Hewlett-Packard Worldwide Health and Life Sciences Symposium, Orlando, FL, USA, May 2008 Italian Academy of Anti-Aging Medicine, 3rd National Congress, May 2008 Life Link conference, Gleneagles, UK, May 2008 Thinking Digital, Gateshead, UK, May 2008 Anti-Ageing Skin Care Conference 2008, London, UK, June 2008 IdeaCity08, Toronto, Canada, June 2008 BioBarCamp, Mountain View, CA, USA, August 2008 SciFoo, Mountain View, CA, USA, August 2008 European Congress on Anti-Aging and Aesthetic Medicine, Dusseldorf, Germany, September 2008 13th Future of Health and Technology Institute Conference, Cambridge, MA, USA, September 2008 18 International Workshop on postponing ageing, Tallinn, Estonia, October 2008 2008 Conference of the Libertarian Alliance, London, UK, October 2008 4th European Futurists Conference, Lucerne, Switzerland, October 2008 The Future, Hamburg, Germany, October 2008 Summit on the Global Agenda, Dubai, November 2008 Changing the World, Toronto, Canada, November 2008 Convergence ‘08, Mountain View, CA, USA, November 2008 ASU workshop on the systems biology of aging, Tempe, AZ, USA, December 2008 BIL 2009, Monterey, CA, USA, February 2009 Workshop on Anti-Aging Medicine, Volterra, Italy, March 2009 4th World Congress of Regenerative Medicine, Bangkok, Thailand, March 2009 Eisai Symposium in Neuroscience, London, UK, April 2009 International Association of Biomedical Gerontology, 13th Congress, Montreal, Canada, May 2009 Metanexus Conference, Phoenix, AZ, USA, July 2009 Life Aid, Brussels, Belgium, September 2009 World Stem Cell Summit, Baltimore, MD, USA, September 2009 Glenn Foundation Symposium on the Biology of Aging, Cambridge, MA, USA, September 2009 14th Future of Health Technology Summit, Cambridge, MA, USA, September 2009 IQPC Life Settlements Summit, New York, NY, USA, October 2009 Singularity Summit, New York, NY, USA, October 2009 2nd European Conference on Anti-Aging and Aesthetic Medicine, Mainz, Germany, October 2009 Women’s Forum Global Meeting, Deauville, France, October 2009 Brocher Foundation symposium, Geneva, Switzerland, October 2009 TED MED 2009, San Diego, CA, USA, October 2009 BIL:PIL, San Diego, CA, USA, October 2009 Manhattan Beach Project, Manhattan Beach, CA, USA, November 2009 UK Society of Cosmetic Scientists, London, UK, December 2009 Systems biology of aging, 2nd annual conference, Baltimore, MD, USA, December 2009 LIFT, Geneva, Switzerland, May 2010 Anti-Aging Medicine conference, Lisbon, Portugal, May 2010 American Aging Association, Portland, OR, USA, June 2010 World Future Society, Boston, MA, USA, July 2010 European Respiratory Society, Barcelona, Spain, September 2010 Our Common Future, Essen, Germany, November 2010