PHS 398 (Rev. 9/04), Biographical Sketch Format Page s3

Biosketch (updated 05-14-06): BIOGRAPHICAL SKETCH

NAME POSITION TITLE George McNamara, Ph.D. Support Scientist

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) State University of New York at Albany B.S. 1981 Biology

University of Illinois at Urbana-Champaign Ph.D. 1987 Genetics & Development

A. Positions and Honors Positions and Employment 1981-1986 Graduate Teaching Assistant, Department of Genetics & Development, University of Illinois at Urbana-Champaign. Ph.D. in the laboratory of Professor Robert P. Futrelle. 1987-1988 Associate Research Specialist, Department of Bacteriology, University of Wisconsin-Madison. 1989-1991 Research Associate, Department of Meat and Animal Science and Primate Research Center, University of Wisconsin-Madison. 1992-1997 Applications Scientist, Universal Imaging Corporation, West Chester, PA. 1997-2000 Applications Scientist, Applied Spectral Imaging, Inc., Carlsbad, CA. 2000-2005 Imaging Scientist, Congressman Dixon Cellular Imaging Core, Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, CA. 2005-present Support Scientist, Division of Cancer Immunotherapeutic and Tumor Immunology (CITI), City of Hope National Medical Center, Duarte, CA. Other Experience and Professional Memberships 1989 American Association for the Advancement of Science 1999 SKYUsers E-Group (founder and moderator) 1999 International Society for Analytical Cytology 1995 Society for Developmental Biology 1997 Royal Microscopical Society 2000 Histochemical Society 2000 Microscopy Society of America 2001 National Society for Histotechnology 2002 Society for Molecular Imaging 2004 Journal of Histotechnology (Editorial Board member) Honors 2001 Engineering development award for “In Vivo Fluorescence Emission Tomography”, CHLA. 2002 Henry L. Guenther Foundation award for “Small Animal In Vivo Fluorescence and Bioluminescence Tomography Instrument”, CHLA. B. Selected peer-reviewed publications McNamara G: Silver Grain Counting. J. NIH Res. 5(11): 70, 1993. McNamara G: Fluorescence Microscopy. J. NIH Res. 6(10): 80, 1994. Page 1 Biosketch (updated 05-14-06): McNamara G: Introduction to fluorescence immunocytochemistry, in D.L. Spector, R. Goldman, L. Leinwand (eds.), Cells: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1997. (reprinted in Spector and Goldman 2005). Zitzelsberger H, Fung J, Janish C, McNamara G, Bryant PE, Riches AC, Weier H-UG: Spectral karyotyping (SKY™) analysis of heritable effects of radiation-induced malignant transformation. SPIE Proc. 3605: 325- 331, 1999. DiFilippantonio M, Ried T, McNamara G, Bieber FR: Microscopy and image analysis (Unit 4.4 in Supplement 22) in Current Protocols in Human Genetics. ISBN: 0-471-03420-7. John Wiley & Sons. New York, 1999. Soenksen DC, McNamara G, Garini Y, Katzir N: Method of cancer cell detection. US Patent 5,995,645, 1999. McNamara G, Soenksen D, Cabib D, Buckwald RA: In situ method of analyzing cells. US Patent 6,007,996, 1999. Weier H-UG, Smida J, Zitzelsberger H, Lersch RA, Hung J, Hsieh HP, Salassidis K, McNamara G, Pedersen RA, Fung J, Cytogenetic analysis of interphase cells using spectral imaging [SIm] technology. SPIE Proc 3920: 76-85, 2000. Garini Y, McNamara G, Soenksen D, Cabib D, Buckwald RA: In-situ method of analyzing cells. US Patent 6,165,734, 2000. Macville MV, Van Der Laak JA, Speel EJ, Katzir N, Garini Y, Soenksen D, McNamara G, de Wilde PC, Hanselaar AG, Hopman AH, Ried T: Spectral imaging of multi-color chromogenic dyes in pathological specimens. Anal Cell Pathol 22: 133-142, 2001. Avramis IA, Christodoulopoulos G , Suzuki A, Laug WE, Gonzalez-Gomez I, McNamara G, Sausville EA, Avramis VI: In vitro and in vivo evaluation of the tyrosine kinase inhibitor NSC680410 against human leukemia and glioblastoma cell lines. Cancer Chemotherapy Pharmacology 50: 479-489, 2002. Wang X, Ge S, McNamara G, Hao QL, Crooks GM, Nolta JA: Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells. Blood 101: 4201-4208, 2003. Chantrain C, DeClerck Y, Groshen S, McNamara G: Computerized quantification of tissue vascularity using high resolution slide scanning of whole tumor sections. J. Histochem Cytochem 51: 151-157, 2003. Wang X, Rosol M, Ge S, Peterson D, McNamara G, Pollack H, Kohn DB, Nelson MD, Crooks GM: Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminescence imaging. Blood 102: 3478-3482, 2003. . DOI 10.1182/blood-2003-05-1432. Sukumaran SK, McNamara G, Prasadarao NV: Escherichia coli K-1 interaction with human brain microvascular endothelial cells trigger phospholipase C-gamma 1 activation downstream of P13-kinase. J Biol Chem 278: 45753-45762. 2003. DOI: 10.1074/jbc.M307374200. McNamara G: Introduction to Fluorescence Immunocytochemistry, in D.L. Spector, R. Goldman, (eds.), Basic Methods in Light Microscopy. Protocols and Concepts from Cells: A laboratory manual and Live Cell Imaging: A laboratory manual. Cold Spring Harbor Laboratory Press, 2005. McNamara G: Color balancing histology images for presentations and publication. J Histotechnology 28: 81- 88, 2005. http://home.earthlink.net/~geomcnamara/McNamara2005JoH28n2pp81-88.pdf McNamara G, DiFilippantonio M, Ried T: Microscopy and image analysis (Unit 4.4) in Current Protocols in Human Genetics. 4.4.1-4.4.34. ISBN: 0-471-03420-7. John Wiley & Sons. New York, 2005. Serrano LM, Pfeiffer T, Olivares S, Numbenjapon T, Bennitt J, Kim D, Smith D, McNamara G, Al-Khadimi Z, Rosenthal J, Forman SJ, Jensen MC, Cooper LC: Differentiation of naive cord blood T cells into CD19-specific cytolytic effectors for post-transplant adoptive immunotherapy. Blood 107: 2643-2652, 2006. Wang X, Ge S, Gonzalez I, McNamara G, Rountree CB, Xi KK, Huang G, Bhushan A ,Crooks GM: Formation of pancreatic duct epithelium from bone marrow during neonatal development. Stem Cells 24: 307-317, 2006.

Biosketch (updated 05-14-06): Ge S, Crooks GM, McNamara G, Wang X: Fluorescent immunohistochemistry and In situ hybridization analysis of mouse pancreas using low power antigen retrieval technique. J Histochem Cytochem 2006. http://www.jhc.org/cgi/content/abstract/jhc.5B6902.2006v1. doi:10.1369/jhc.5B6902.2006

Balic M, Lin H, Datar RH, Young L, Hawes D, Armando G, McNamara G, Cote RJ: The majority of early disseminated cancer stem cells detected in bone marrow of breast cancer patients have a stem cell phenotype. In press. McNamara G, Gupta A, Reynaert J, Coates TD, Boswell C: Spectral imaging microscopy web sites and data. Cytometry. In press. McNamara G, Yanai A, Khankaldyyan V, Laug WE: Low magnification confocal microscopy of tumor angiogenesis in Confocal Microscopy: Methods and Protocols. Humana Press. Totowa, submitted. Science Websites Boswell C, McNamara G (2005) Fluorescent Spectra: An interactive, exploratory website. http://www.mcb.arizona.edu/ipc/fret/default.htm McNamara G, Boswell C (2005) PubSpectra http://home.earthlink.net/~pubspectra/ McNamara G (2005) Multi-Probe Microscopy http://home.earthlink.net/~mpmicro/ McNamara G (2005) Tiki Goddess (microscope slide scanning) http://home.earthlink.net/~tiki_goddess/ McNamara G (2005) George McNamara Homepage http://home.earthlink.net/~geomcnamara/ Additional Publications Christenson MA, McNamara G: Recent advances in multidimensional imaging. Biophotonics Intl. 1(2): 42-46, 1995.