James Warbrick-Smith

Joel Benjamin Raffel

GMC No. 7040692 Date of Birth: 05/03/1985 Address: 26 Cobbold Road E-mail: [email protected] London W12 9LW Phone: 07814632510

TRAINING POSTS: FY1 2009-2010 – Whittington Hospital, Archway, London. North Central Thames Foundation School 4 months General Surgery 2 months Acute Medicine 2 months Care of Older Patients 4 months Cardiology FY2 2010-2011 – Royal London Hospital, London. North East Thames Foundation School 2 months Clinical psychiatry. Also on acute stroke rota 6 months Academic and clinical neurology, under supervision of Professor Gavin Giovannoni. Also on acute stroke rota 4 months Medical Assessment Unit ST1-ST2 2011-2013 – Imperial College Healthcare NHS Trust – Academic Clinical Fellowship in Neurology 6 months Clinical neurology, Charing Cross Hospital 6 months Academic neurology, Multiple sclerosis research group, under supervision of Professor Richard Reynolds and Dr Richard Nicholas 6 months Cardiology, Hammersmith Hospital 6 months Acute Medicine, Hammersmith Hospital Clinical Fellow in Neurology 2013-2017 – Imperial College Healthcare NHS Trust – undertaking PhD on the role of neuroimaging in predicting response to treatment in multiple sclerosis. MRCP (UK): All three sections passed on first attempt Part 1 – Diet 2010/03 – Score 687 (Pass mark 521) Part 2 Written – Diet 2011/02 – Score 774 (Pass mark 425) Part 2 PACES – Diet 2012/03 – Score 155/172 (Pass mark 130) ACADEMIC ACHIEVEMENTS: 2006-2009 Clinical Medicine, Green College, Oxford University  6th year: ‘Distinction’ for academic performance throughout clinical school.  6th year: ‘Merit’ in Final Year BMBCh examinations, and nomination for George Pickering Prize (nomination signifies top 12 result in Finals).  5th year: 93/100 in Neurology written exam (2nd top mark of the year).  5th year: ‘Merit’ in Psychiatry – 148/156 (top mark of the year).  5th year: ‘Merit’ in Emergency Medicine, Orthopaedics and Musculoskeletal Medicine.  4th year: ‘Merit’ in year 4 OSCE.  4th year: ‘Merit’ in Laboratory Medicine Course. 2003-2006 Pre-Clinical Medicine, St. Anne’s College, Oxford University  3rd year: BA in Medical Sciences: 1st class honours. Specialised in neuroscience. My electrophysiology research on the “Role of the NR2B subunit for the induction of LTP in GluRA-/- mice” also received 1st class honours.  2nd year: ‘Merit’ in ‘the nervous system’ examination - 7.3/8 (top mark of the year). 1997-2003 James Gillespie's High School, Edinburgh

PUBLICATIONS:  Raffel J, Gafson AR; Malik O; Nicholas R. Anti-JC virus antibody titres increase over time with natalizumab treatment. Multiple Sclerosis Journal. July 2015 – accepted for publication.  Amor S, van der Star BJ, Bosca I, Raffel J, Gnanapavan S, Watchorn J, Kuhle J, Giovannoni G, Baker D, Malaspina A, Puentes F. Neurofilament light antibodies in serum reflect response to natalizumab treatment in multiple sclerosis. Multiple Sclerosis Journal. 2014;20(10):1355-62  Raffel J, Dobson R, Gafson A, Mattoscio M, Muraro P, Giovannoni G. Multiple sclerosis therapy and Epstein-Barr virus antibody titres. Mult Scler Relat Disord. 2014;3:372-4  Stansfeld S, Dinos S, Raffel J. Environmental influences: the workplace and mental health – models, vulnerability factors, and interventions. In: Sloboda Z, Petras H. (eds.) Defining Prevention Sci- ence. New York, USA: Springer; 2014. p. 219-250.  Raffel JB, Malik O, Nicholas R. Assessing dalfampridine efficacy in the physician's office. Multiple Sclerosis Journal. 2014;20(1):24-6  Raffel JB, Thompson J. Carbon monoxide from domestic coffee roasting. Annals of Internal Medi- cine. 2013 159(11):795-6.  Raffel JB, Hunt D, Topping J, Bremner J, Brown K, Giovannoni G. Assay selection affects JC virus serostatus classification in multiple sclerosis. Annals of Neurology. 2012;72(2):295-6  Sharrief AZ, Raffel J, Zee DS. Vitamin B12 Deficiency With Bilateral Globus Pallidus Abnormalit- ies. Arch Neurol. 2012;69(6):769-772.  Raffel JB, Al-Lawati A, Murch N. Rash and dyspnoea in a 39 year old man. BMJ. 2011;29:343.  Romberg C, Raffel J, Martin L, Sprengel R, Seeburg PH, Rawlins JN, Bannerman DM, Paulsen O. Induction and expression of GluA1 (GluRA)-independent LTP in the hippocampus. Eur J Neurosci. 2009;29(6):1141-52.  Raffel J, Frith P. Examination of Visual Acuity. The Journal of Clinical Examination 2008, (6): 25- 28. ONGOING RESEARCH PROJECTS:  Main PhD project on the role of neuroimaging, including TSPO PET, in predicting response to treatment in multiple sclerosis.  Audit on natalizumab experience at Imperial, and early markers of predicting response to treatment.  Audit on JCV antibody testing at Imperial, and longitudinal change in titres.  Research survey on putative link between family history of multiple sclerosis and CNS infections. Currently going through ethics approval.  Validating MSIS-29 questionnaire, and its role in predicting clinical outcomes in multiple sclerosis in large patient cohort.  Supervising student conducting research into pathways for formative care in multiple sclerosis.  Designing computerised tool for data collection in multiple sclerosis as part of OPTIMISE consortium, with Professor Paul Matthews.  Created resource at Imperial College NHS Trust whereby all CSF samples collected for clinical reasons in Neurology Patient Investigation Unit, are also processed and stored in research facility for future research.  van der Star BJ, Raffel J. Neurofilament Light as an immune target for pathogenic antibodies. Submitted to Neurobiology of Disease.  Raffel JB, Reynolds R, Nicholas R. IL17 Receptor Expression in Astrocytes in Multiple Sclerosis. Manu- script being prepared for submission. NATIONAL / INTERNATIONAL PRESENTATIONS:  Raffel J, Gafson A, Malik O, Nicholas R. Longitudinal anti-JCV antibody titres increase with natalizumab treatment. International meeting - ECTRIMS. Barcelona, Spain. October, 2015.  Raffel J, Gafson A, Dahdaleh S, Malik O, Nicholas R. Post-natalizumab relapses and MRI activity do not predict long-term disability outcomes. International meeting - ECTRIMS. Barcelona, Spain. October, 2015.  Feeney C, Scott G, Raffel J, Coello C, Searle G, Gunn R, Sharp D. Kinetic analysis of the translocator protein positron emission tomography ligand 18[F]-GE180 in the human brain. International meeting – 2015 Society for Neuroscience Annual Meeting. Chicago, USA. October 2015.  Raffel J, Gafson A, Malik O, Nicholas R. Anti-JCV titres increase over time with natalizumab treatment natalizumab. National meeting - Association of British Neurologists. Harrogate, UK. May, 2015.  Raffel J, Gafson A, Dahdaleh S, Malik O, Nicholas R. Early prediction of long-term response to natalizumab in multiple sclerosis. National meeting - Association of British Neurologists. Harrogate, UK. May, 2015.  Raffel J, Nicholas R, Roncaroli F, Reynolds R. Astrocytes upregulate interleukin-17 receptor expression in white matter lesions in multiple sclerosis. International meeting – 2014 Joint ACTRIMS / ECTRIMS meeting. Boston, USA. September 2014.  Raffel JB, Guo YK, Matthews PM. OPTIMISE: A vision for personalised medicine in multiple sclerosis. National meeting – Launch of Data Science Institute by Imperial College London and Huawei Technologies Co. April 2014.  Raffel JB, Hunt D, Topping J, Bremner J, Brown K, Giovannoni G. Classification of JC virus serostatus depends upon assay selection: a comparison of Biogen and HPA assays. National meeting - Association of British Neurologists. Brighton, UK. May, 2012.  Raffel J, Dobson R, Giovannoni G. The effect of natalizumab and beta interferon on urinary free light chains and anti-EBV nuclear antigen-1 antibodies in relapsing remitting multiple sclerosis. National meeting - Association of British Neurologists. Newcastle, UK. October 2011.  Raffel J, Romberg C, Rawlins N, Paulsen O. ’Memories are made of this? The role of NMDA receptors in the induction of long-term potentiation (LTP) in wildtype and GluRA knockout mice.’ Prize-winning poster presentation. Meeting for Clinician Scientists in Training, Medical Research Society, Royal College of Physicians, London. February 2011.  Raffel J. When the picture doesn’t fit – Psychogenic non-epileptiform seizures on the background of domestic abuse in pregnancy. Presented at The Royal College of Obstetricians and Gynaecologists National Medical Students and Young Doctors Evening. Jan 2010.  Romberg C, Raffel J, Bannerman D, Seeburg P, Sprengel R, Rawlins N, Paulsen O. Different induction requirements for GluRA-independent and wild type LTP in the hippocampus. Presented at the Federation of European Neurosciences conference, Austria. June 2006. NATIONAL ESSAY PRIZES: 2009 1st prize in national “Herbert Reiss Memorial Prize” for best case report by medical student or junior doctor, awarded by Royal College of Obstetricians and Gynaecologists. 2008 2nd prize in “National Faculty of General and Community Psychiatry Medical Student Essay Prize” for essay on the aetiology of schizophrenia, awarded by the Royal College of Psychiatrists. 2008 3rd prize in “National Parkinson’s Disease Essay Prize” for essay on the future of Parkinson’s Disease management, awarded by the British Geriatrics Society. AWARDS: 2009 National “Graduate of the Year Award 2009” awarded by Real World Magazine; 1 st prize in the “Contribution to University Award” category for outstanding extra-curricular achievement. 2009 Nominated for the George Pickering prize for Oxford University Final Year Exams (nomination signifies top 12 result in Finals; top prize awarded to single top student based upon multiple extension vivas). 2008 Proxime accessit in Hobson Mann scholarship (awarded to the top six clinical medicine students of the 4th year, Oxford University). 2007 Domus Merit Award for outstanding academic and extra-curricular contribution to Green College, Oxford. 2006 Scholarship for outstanding academic achievement at St Anne’s College, Oxford. ACADEMIC TEACHING: 2015 Supervised Masters student for 8-week internship, using immunohistochemistry to investigate the phenotype of microglia in different multiple sclerosis lesions. 2015 Supervised medical student for 10-week BSc project, investigating the use of formative care in multiple sclerosis, and developing predictive models for who may benefit from these pathways. 2014 Supervised medical student for 10-week BSc project, investigating the MSIS-29 questionnaire in multiple sclerosis, and its role in predicting clinical outcomes and monitoring disease activity prospectively. 2009-2010 Promoted to position of “Clinical Lecturer” at St Anne’s College, Oxford University. 2006-2010 Neuroscience Tutor, St. Anne’s College, Oxford University. Tutoring 2nd year medical student in topic such as ‘vision’, ‘audition’, ‘posture’, ‘depression’, ‘schizophrenia’, ‘Parkinson’s disease’, ‘speech’ and ‘long-term potentiation’. In total, I have given over 50 tutorials. 2005 Oxbridge Cultural Exchange Project charity program - English Teacher in rural China (July 10 th – August 25th). PROFESSIONAL EXPERIENCE: 2014 Contributing reviewer for Expert Opinion On Drug Metabolism and Toxicology journal. 2012-2013 Lead SHO and rota coordinator for cardiology at Hammersmith Hospital. Redesigned rota to increase continuity of care on ward. 2011-2012 6 months as a Neurology SHO at Charing Cross Hospital. Performed over 120 lumbar punctures. 2010-2011 8 months on “acute stroke rota” at Royal London Hospital, whereby I clerked all stroke admissions, evaluated for thrombolysis (with consultant telecommunication support) and administered thrombolysis. 2010- Trained and employed as a “blinded assessing physician” for Camms 323, 324, and 03409 Phase 3 randomised controlled trials for patients with relapsing-remitting multiple sclerosis. I perform blinded EDSS and MSFC neurological examinations on study patients. 2009 Medical School elective: 4 weeks Subinternship in Clinical Neurology, working with Dr David Zee, Johns Hopkins Hospital, Baltimore, USA. 5 weeks practising general medicine and surgery in rural Vanuatu (South Pacific island). 2004 10 weeks Tzedek Charity Volunteer at the Shekhinah Clinic Hospital in Tamale, Ghana. PROFESSIONAL SERVICE: 2007-2008 Part of three-person executive committee that organised national 2-day Medsin Global Health Conference 2008. We attracted over 60 expert national and international speakers, and 430 conference delegates. 2005-2006 Conductor of the St. Anne’s & St. John’s College Orchestra, Oxford. This involved leading weekly rehearsals with the 45-person orchestra, and performing in public concerts. MEMBERSHIP: 2010- Associate Member: Association of British Neurologists. 2010- Young Fellow: Royal Society of Medicine. 2009- Member: Whittington Hospital Football Team, London. 2007-2008 As part of "The Tingewick Society", I helped create a pantomime, featuring a cast of 120 medical students. An audience of 1800 donated £17500 to charity over four nights.