Supplemental Table 2 Literature Verification of the Gene Sets Obtained from the Cent-Stat

Supplemental Table 2 Literature verification of the gene sets obtained from the cent-stat method in AD

GO term GO term

ACTIN BINDING[1] NEGATIVE REGULATION OF PROGRAMMED

CELL DEATH[2] ACTIN CYTOSKELETON ORGANIZATION AND NEGATIVE REGULATION OF RNA METABOLIC

BIOGENESIS[3] PROCESS ACTIN FILAMENT BASED PROCESS NEGATIVE REGULATION OF

TRANSCRIPTION[4] ACTIN FILAMENT BINDING[1] NEGATIVE REGULATION OF TRANSCRIPTION

DNA DEPENDENT ACTIN FILAMENT BUNDLE FORMATION NERVOUS SYSTEM DEVELOPMENT[5]

ACTIN FILAMENT ORGANIZATION[6] NEUROPEPTIDE HORMONE ACTIVITY[4]

ACTIVATION OF NF KAPPAB TRANSCRIPTION NUCLEAR CHROMOSOME PART

FACTOR[7] AEROBIC RESPIRATION[8] NUCLEAR IMPORT[9] ANTI APOPTOSIS[10] NUCLEAR LUMEN APOPTOSIS GO NUCLEAR TRANSPORT[11] CELLULAR LOCALIZATION[12] NUCLEOBASE NUCLEOSIDE NUCLEOTIDE

KINASE ACTIVITY[13] CELLULAR RESPIRATION[14, 15] NUCLEOCYTOPLASMIC TRANSPORT[16]

CENTRAL NERVOUS SYSTEM NUCLEOSIDE TRIPHOSPHATASE

DEVELOPMENT[17] ACTIVITY[18] CHROMATIN MODIFICATION[19] ORGANELLE ENVELOPE[20] CHROMOSOME ORGANIZATION AND ORGANELLE INNER MEMBRANE[4]

BIOGENESIS[21] CLATHRIN COATED VESICLE[22] ORGANELLE LUMEN COATED VESICLE[23] ORGANELLE MEMBRANE[24]

COFACTOR CATABOLIC PROCESS[25] ORGANELLE ORGANIZATION AND

BIOGENESIS COVALENT CHROMATIN MODIFICATION PEPTIDE METABOLIC PROCESS CYTOPLASMIC MEMBRANE BOUND VESICLE PHOSPHOTRANSFERASE ACTIVITY

PHOSPHATE GROUP AS ACCEPTOR CYTOPLASMIC VESICLE[26] POSITIVE REGULATION OF BINDING

CYTOSKELETAL PROTEIN BINDING POSITIVE REGULATION OF DNA BINDING

CYTOSKELETON[27] POSITIVE REGULATION OF I KAPPAB KINASE

NF KAPPAB CASCADE CYTOSKELETON ORGANIZATION AND POSITIVE REGULATION OF SIGNAL

BIOGENESIS[28] TRANSDUCTION ENERGY DERIVATION BY OXIDATION OF POSITIVE REGULATION OF TRANSCRIPTION

ORGANIC COMPOUNDS[29, 30] FACTOR ACTIVITY ENVELOPE[31] POST TRANSLATIONAL PROTEIN

MODIFICATION[32] ESTABLISHMENT AND OR MAINTENANCE OF PROGRAMMED CELL DEATH[33]

CHROMATIN ARCHITECTURE ESTABLISHMENT OF CELLULAR PROTEIN IMPORT

LOCALIZATION[34] ESTABLISHMENT OF PROTEIN PROTEIN KINASE CASCADE[36]

LOCALIZATION[35] GTP BINDING[37] PROTEIN LOCALIZATION[35] GTPASE ACTIVITY[38] PROTEIN SERINE THREONINE KINASE

ACTIVITY[39] HISTONE MODIFICATION[40] PROTEIN TARGETING HYDROLASE ACTIVITY ACTING ON ACID PROTON TRANSPORTING TWO SECTOR

ANHYDRIDES ATPASE COMPLEX[41] I KAPPAB KINASE NF KAPPAB CASCADE[42] PYROPHOSPHATASE ACTIVITY[43] IDENTICAL PROTEIN BINDING[44] REGULATION OF APOPTOSIS[45]

INTRACELLULAR TRANSPORT[46] REGULATION OF BINDING[24] KINASE ACTIVITY[47] REGULATION OF DEVELOPMENTAL PROCESS

MACROMOLECULE LOCALIZATION REGULATIO N OF DNA BINDING[48] MAP KINASE KINASE KINASE ACTIVITY[49] REGULATION OF ENDOTHELIAL CELL

PROLIFERATION MEMBRANE BOUND VESICLE REGULATION OF I KAPPAB KINASE NF KAPPAB CASCADE

MEMBRANE ENCLOSED LUMEN REGULATION OF MOLECULAR

FUNCTION[50] MEMBRANE ORGANIZATION AND REGULATION OF PROGRAMMED CELL

BIOGENESIS[51] DEATH MITOCHONDRIAL ENVELOPE REGULATION OF RNA METABOLIC PROCESS

MITOCHONDRIAL INNER MEMBRANE[52] REGULATION OF TRANSCRIPTION DNA

DEPENDENT MITOCHONDRIAL MEMBRANE[53] REGULATION OF TRANSCRIPTION FACTOR

ACTIVITY[54] MITOCHONDRIAL MEMBRANE REGULATION OF TRANSCRIPTION FROM

ORGANIZATION AND BIOGENESIS RNA POLYMERASE II PROMOTER

MITOCHONDRIAL MEMBRANE PART[53] RIBONUCLEOPROTEIN COMPLEX[55]

MITOCHONDRIAL OUTER MEMBRANE[56] RNA PROCESSING[57] MITOCHONDRIAL PART[58] SMALL CONJUGATING PROTEIN BINDING

MITOCHONDRIAL TRANSPORT[59] SYNAPTIC VESICLE[60] MITOCHONDRION[61] TRANSCRIPTION FACTOR BINDING

MITOCHONDRION ORGANIZATION AND TRANSCRIPTION FROM RNA POLYMERASE II

BIOGENESIS PROMOTER NEGATIVE REGULATION OF APOPTOSIS TRANSCRIPTION REPRESSOR ACTIVITY[62]

NEGATIVE REGULATION OF CELLULAR TRANSFERASE ACTIVITY TRANSFERRING

COMPONENT ORGANIZATION AND PHOSPHORUS CONTAINING GROUPS

BIOGENESIS NEGATIVE REGULATION OF CELLULAR TRANSPORT VESICLE[63]

METABOLIC PROCESS NEGATIVE REGULATION OF DEVELOPMENTAL TRICARBOXYLIC ACID CYCLE INTERMEDIATE

PROCESS METABOLIC PROCESS NEGATIVE REGULATION OF METABOLIC TRNA PROCESSING

PROCESS NEGATIVE REGULATION OF NUCLEOBASE UBIQUITIN BINDING[64, 65]

NUCLEOSIDE NUCLEOTIDE AND NUCLEIC ACID

METABOLIC PROCESS

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