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Table S2. Genes commonly down-regulated by STAT5A and HP1alpha

Illumina ID Gene Symbol Control HP1alpha STAT5A[Y964F] sh-STAT5A sh-HP1a Gene Descriptioin

1240440 TXNIP 2616.25 217.8 264.5 4256.413175 10003.30882 Thioredoxin-interacting protein 6270138 TACSTD2 2742.55 340.8 582.9 4078.00689 4705.645339 Tumor-associated calcium signal transducer-2 1510424 S100P 3710.35 474.9 550.8 6053.138973 8690.578097 S-100 family protein

1340021 AGR2 4817.75 734.2 1621.1 8208.388584 5962.52231 Metastasis-Associated Anterior Gradient 2 4640086 FOXQ1 3851.3 631.2 1124.9 6306.30252 6186.511655 Forkhead box Q1

2680110 TM4SF1 2746.05 479.7 698.5 3131.045788 3811.964873 Transmembrane-4-L-six- family-1 7510132 OLR1 946.15 175 272.2 869.6248265 1170.29178 Opioid Receptor-Like 1 540377 CXCL5 3166.95 589.4 1191.6 3593.136362 4262.250238 C-X-C motif chemokine 5

5570139 QPCT 2265.9 440.8 624.9 3808.232068 4050.82885 Glutaminyl-peptide cyclotransferase

7650358 TGFBI 2308.95 461.2 785.7 2567.239322 4978.541734 Transforming growth factor beta induced

830056 FOXA1 2319.9 471.8 659.5 2977.765497 3187.048437 Forkhead-box A1

2940291 QPRT 883.55 201.2 380 1063.627687 1822.760376 Quinolate phosphoribosyltransferase

1850674 TRIM31 450.6 103.4 142.7 481.9197309 891.096861 Tripartite motif-containing protein 31

7050673 CDH17 915 214.1 401.9 1172.36008 2208.071102 Cadherin 17 1110180 RORA 428.1 100.2 142.7 458.0942675 437.5196873 RAR-related orphan receptor A

4560543 TSPAN8 1481.25 354.3 547.3 1823.621812 2268.836344 Tetraspanin-8 (also D6.1A/CO-029)

380010 CXCL5 738.5 177.4 321.5 775.7212243 902.1961109 C-X-C motif chemokine 5

1070189 AXIN2 3564.6 867.3 1349.7 3910.49477 4371.946747 Axis inhibition protein 2 (also Axin-like protein, Axil)

2190184 PRSS23 2036.2 500.7 620.8 3062.391835 2785.798194 Serine protease 23

6480471 LOC645553 431.15 108.9 145.8 477.2270992 719.9546756 LOC645553

5390121 GDPD3 445.7 113.5 154.3 474.6174405 614.1639881 Glycerophosphodiester phosphodiesterase domain-containing protein 3 1570661 CYP2J2 1345.05 345.4 435.6 1379.633471 1495.735124 Cytochrome P450 2J2

2600397 RPESP 687.2 180.2 245 849.3123642 881.6637351 RPE-spondin

7200435 ASCL2 1186.6 313.3 677.4 1873.528663 2015.50029 Achaete-scute complex homolog 2 (also HASH2)

4150600 EIF1AY 808.15 216.7 262 1019.321203 997.4003165 Eukaryotic translation initiation factor 1A

3400097 MUC20 299.1 80.5 114.8 339.9888052 494.2072121 Mucin-20

4780072 TCEAL3 356.15 99 114.7 448.2702648 486.7141548 Transccription elongation factor A (SII)-like 3 7570484 TFF3 635.3 178.4 285.4 615.899176 1233.3381 Trefoil factor 3 4570255 LEF1 471.4 134.6 224.1 766.5112528 649.1033008 Lymphoid enhancer- binding factor-1

110181 KIAA1199 1350.9 389.9 613.5 1154.910235 1383.885655 KIAA1199

5260343 SCG5 821.4 237.3 332 1314.24 2504.991874 Secretogranin V

2060450 NNT 386 113.2 127.7 608.9993329 557.7558372 Nicotinamide nucleotide (NAD(P)) transhydroenase

6520598 SLC2A10 436.5 129.7 180.5 531.7430497 797.9823083 Solute carrier family 2, facilitated glucose transporter member 10

50168 GRHL3 282.05 84.4 106.5 338.7463452 395.7290355 Grainyhead-like 3

5080576 KIT 297 89.9 137.9 302.0748576 338.8071603 c-Kit (also CD117)

5340017 H19 294.65 90.6 101 389.5009865 303.5231568 H19 imprinted maternally expressed transcript

5560369 ALDH3A1 780.65 245.4 304.7 753.2089697 992.1351818 Aldehyde dehydrogenase 3 family, member A1 4390398 LCN2 1445.8 461.2 600.2 973.5909652 3568.890137 Lipocalin-2

1980255 RNF39 255.75 82.1 81.6 253.1851719 326.0995702 RING finger protein 39

3450189 HOXA13 638.25 208.8 220.5 828.9211587 1103.834887 Homeobox protein A13

610437 CD24 3266.1 1072.9 1278.7 4357.816501 2820.171355 Cluster of differentiation 24

4830520 KRT80 676.5 222.8 199.4 746.0424671 711.3852376 Keratin 80

3460014 C4ORF18 594.35 196.6 275.1 807.269652 904.6043501 Chromosome 4 open reading frame 18

870376 C9ORF152 325.9 110 139.5 424.1453809 540.0854943 Chromosome 9 open reading frame 152

5310360 TLE4 280.25 94.8 148.3 320.1716524 427.3612892 Transducin-like enhancer of split 4

6760037 SYTL2 1258.3 432.1 391 1564.711793 1953.921826 Synaptotagmin-like 2

6400564 HS.560343 366 126.7 155 439.0456781 421.813071 RAR-related orphan receptor A

2340193 KRT80 254.75 88.8 98.1 302.2146715 301.9853735 Keratin 80 2810601 LEF1 509.75 178.8 272.7 881.0280136 677.9934635 Lymphoid enhancer- binding factor-1

670754 TMEM30B 317.35 111.7 139 369.6044177 442.6756359 Transmembrane protein 30B

3940703 RORA 296.3 104.6 120.2 307.1805246 354.0056393 RAR-related orphan receptor A

3170440 BCL11A 267.9 94.8 132.8 301.3645161 304.8580645 B-cel lymphoma/leukemia 11A

940504 RUNX2 247.3 88.2 91.3 342.0260234 259.7734649 Run-related transcription factor 2

1710242 C1ORF59 486.15 174.3 226.3 561.3826325 638.0463204 HEN1 methyltransferase homolog 1 4730523 IGFL2 271.25 98 93.1 337.7328431 318.2312092 Insulin like growth factor 2

4490544 LY6G6D 178.15 64.5 73.2 255.9848711 237.1304613 Lymphocyte antigen 6 complex, locus G6D 1710053 SERP2 200.25 73.4 90.6 193.5815377 258.1087169 Stress-associated endoplasmic reticulum protein family member 2 7210632 AKR1C3 666.8 245.8 291.8 969.1243091 792.9766745 Aldo-keto reductase family 1 member C3

730156 ICAM2 227.1 84 102 268.2378178 326.45625 Intercellular adhesion molecule 2 5810278 SYTL2 412.05 155.2 168.1 441.7472973 565.7335135 Synaptotagmin-like 2

3460296 HDGFRP3 197.45 74.5 97.6 247.1958154 248.8994392 Hepatoma-derived growth factor related protein 3

730739 TCEAL3 159.35 60.2 73.6 169.8515759 197.4752865 Transccription elongation factor A (SII)-like 3 5810494 LOC100129195 309.65 118.3 172 313.2123451 380.074823 LOC100129195

6020575 NNT 201.8 77.5 88.8 293.780023 222.1885189 Nicotinamide nucleotide (NAD(P)) transhydroenase

3140463 AGR2 225 87.6 110.1 288.5341727 269.1097122 Anterior gradient homolog 2 630243 PRR15L 283.45 110.4 124.5 338.6151108 377.6343354 Proline rich 15-like

6200148 PCP4 218.65 86.6 94.5 236.4349282 302.3437799 Purkinje cell protein 4

2260731 ERAP2 500.95 198.5 227.1 579.5989315 680.531727 Endoplasmic reticulum aminopeptidase 2

3420452 TSPAN13 1167.5 463.6 502.8 1560.992831 1283.554052 Tetraspanin 13

6940270 MUC13 268.95 108.1 133.2 339.7483645 530.778271 Mucin 13

4150270 ANKRD22 579.85 234.5 280.4 903.7192195 746.0428452 Ankyrin repeat domain 22

130324 TMPRSS2 333.8 135.6 125 393.8301613 447.668871 Transmembrane protease, serine 2 5670475 GCHFR 550.7 225.2 279.2 722.4815073 726.9009421 GTP cyclohydrolase 1 feedback regulator

3440491 GALC 438.75 179.9 173.3 477.7179276 718.020148 Galactosylceramidase

6330608 PTK6 306.25 127.2 147.3 305.2205882 457.0588235 Tyrosine-protein kinase 6

7400537 GSTT1 267.95 111.5 125.8 335.8478018 390.03753 Glutathione S-transferase theta-1

7550292 SELENBP1 346.7 150 187.5 413.3352482 1014.773688 Selenium binding protein 1

2600465 SH3GL2 221.95 96.5 112.6 237.0064645 320.6141261 SH3-domain GRB2-like 2

4860537 SLC7A8 379.05 166.5 213.3 396.3282509 517.2760071 Solute carrier family 7 130181 ANKRD22 398.15 175.5 213.1 548.082786 468.9758073 Ankyrin repeat domain 22

7210326 PSMB8 254.85 112.5 132.2 393.7328338 471.5072207 Proteasome subunit beta type-8 6900053 PPFIBP2 419.25 186.9 211.1 552.1503819 679.9802673 PTPRF interacting protein binding protein 2

3420632 PSMB8 168 75.4 97.5 215.9194631 229.4496644 Proteasome subunit beta type-8

1090326 TIMP4 188.05 84.5 93 195.4419025 275.8658019 Metalloproteinase inhibitor 4

3360669 PODXL2 159.95 72.9 97.2 185.9791304 225.1221739 Podocalyxin-like 2

3420739 SNTB1 421.25 192.9 230.4 730.6446809 559.993617 Beta-1-syntrophin

6590445 RIN2 288.35 134 141.5 359.9244217 474.0843416 Ras and Rab interactor 2

4830632 SLC7A7 227.4 106.3 88.4 218.792674 297.0915751 Y+L amino acid transporter 1

3170594 MAL2 1430.15 692 730.8 2315.62797 946.1298747 Four-transmembrane protein of the MAL family

730040 LAMB3 662.85 324.3 292.5 917.4024214 907.5469626 Lamin beta 3 subunit (also laminin-5 β3)

6220189 HOXB6 408.95 203.2 182.6 423.7371666 633.9088619 Homeobox protein B6

1090390 OAS1 169 84.3 84.8 200.4028369 301.3234043 2'-5'-oligoadenylate synthetase 1

3940673 LOC728285 546.05 272.7 175.6 535.3840552 576.8884926 Keratin associated protein 2-3, 2-4 1110373 C15ORF48 235.9 119.5 124.3 262.6925466 409.2142857 Chromosome 15 open reading frame 48

1230048 ABCB1 413.3 218.2 283.8 430.9341333 713.3558 ATP-binding cassette, sub-family B (MDR/TAP), member 1

2710278 TCEAL1 203.9 110.9 121.4 289.1181448 341.9118247 Transcription elongation factor A (SII)-like 1

2650564 RARRES3 201.9 113.6 115.9 232.5087464 427.0508746 Retinoic acid receptor responder protein 3

2120053 CYP1B1 596.15 336.7 304.5 640.5293951 1040.538318 Cytochrome P450 1B1

5700753 CEACAM1 230.55 133.2 151.2 268.6326251 430.6022961 Carcinoembryonic antigen-related cell adhesion molecule 1

5490240 MAP1LC3A 178.65 104.6 89.2 175.5226477 305.5032276 Microtubule-associated proteins 1A/1B light chain 3A 4120193 PROM2 259.4 153.2 140.6 676.2928571 160.6181583 Prominin 2

6100411 FKBP14 698.7 422 455.4 1326.223079 964.9097266 FK506 binding protein 14

6550026 TICAM2 498.35 304.1 206.9 705.1983752 669.4967873 Toll-like receptor adaptor molecule 2 3800168 SLC2A3 342.3 210.6 245 829.1922414 366.497069 Solute carrier family 2 (facilitated glucose transporter), member 3 1170220 AHSA2 430.25 277.1 158.5 406.970364 490.7770536 Activator of heat shock 90kDa protein ATPase homolog 2

460202 KLK3 149.95 97.5 84.1 196.5308245 260.2200384 Kallikrein-related peptidase 3 (or Prostate- specific antigen)

1940487 STAT5A 147.45 96.7 210.6 38.95479876 161.1450464 Signal transducer and activator of transcription 5A

5290674 KRT20 543.45 358 300.3 446.4766844 1320.124153 Keratin 20

1440324 PPARG 350 234.9 197 336.1554476 662.5954198 Peroxisome proliferator- activated receptor gamma

3120370 CD68 674.8 463.7 285.3 866.4393768 897.0252125 Cluster of Differentiation 68

7650441 FGFBP1 1106.9 777.7 569.3 1244.730091 1777.650392 Fibroblast growth factor binding protein 1 4610520 GCNT3 242.15 172.1 131 401.9386364 325.8397727 Glucosaminyl (N-acetyl) transferase 3

4290148 HIST2H2AA4 291.9 214.3 184.9 860.709244 434.3721446 Histone cluster 2, H2aa4

2350537 MMP7 209.05 154.4 108.5 293.1505747 342.4094828 Matrix metalloproteinase- 7

5570279 HIST1H1C 812.65 627.2 473.7 2938.020137 1150.161314 Histone cluster 1, H1c (Histone H1.2)

610451 HIST2H2AA3 271.9 224.8 176.6 752.5822325 337.3282348 Histone cluster 2, H2aa3 (Histone H2A.2)

5910767 TNFRSF6B 7310.35 6155.7 3258.1 10848.86339 20000 Tumor necrosis factor receptor superfamily member 6B

6580369 DYNLRB1 730.95 618.3 545.8 1786.293297 2059.258389 Dynein light chain roadblock-type 1 (also km23-1)

2640392 TNFRSF6B 1915.6 1756.6 1022.4 2151.501686 5226.054369 Tumor necrosis factor receptor superfamily member 6B 520682 CPA4 519.5 486.4 241.8 293.8179303 2604.399834 Carboxypeptidase A4

830019 PPARG 1272.3 1215.4 932.2 1298.085156 3079.583915 Peroxisome proliferator- activated receptor gamma

7210224 DYNLRB1 1529.2 1479.3 1419.7 4347.379678 4232.134739 Dynein light chain roadblock-type 1 (also km23-1)

6280168 SERPINA3 826.7 808.4 612.1 1068.558681 2112.418884 Serpin peptidase inhibitor, clade A

Total RNA isolated from DLD-1 cells stably expressing the indicated transgene was subjected to microarray analysis using Illumina HumanHT-12 v4 Expression BeadChips. The data were analyzed with GenePattern software (Broad Institute) and only those genes down-regulated by STAT5A[Y964F] and Hp1alpha, and up-regulated by their knock down are shown. The list correspsond to the upper half of Figure 4c. "Yes" in bold indicates over-expressed or important for colorectal cancer development. N.A.: not applicable due to transgene expression. ?: conflicting reports or not clear. No: relevant reference not found.

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