Thomas U. Ahearn, Ph.D., M.P.H

Thomas U. Ahearn, Ph.D., M.P.H. [email protected]

EDUCATION Ph.D. Nutrition and Health Sciences – Epidemiology track 2007 – 2012 Graduate Division Biological and Biomedical Sciences Emory University, Atlanta, GA Dissertation: The investigation and development of dietary and life-style modifiable, pre-neoplastic biomarkers of risk for colorectal neoplasms

M.P.H. Epidemiology 2004 – 2006 Rollins School of Public Health Emory University, Atlanta, GA Thesis: Colorectal mucosa expression of E-cadherin and APC as a potential modifiable, pre-neoplastic biomarker of risk for colorectal neoplasms

B.S. Biology 2001 – 2003 State University of New York at Albany

A.S. Mathematics and Natural Sciences 1998 – 2000 State University of New York at Orange County

RESEARCH EXPERIENCE Post-Doctoral Research Fellow - prostate cancer patho-epidemiology team 2012 - present Department of Epidemiology at the Harvard School of Public Health, Harvard University, Boston, MA  Collaborate with a transdisciplinary team of investigators investigating the etiology, molecular subclassification, and prognostication of prostate cancer  Propose original analyses investigating the molecular epidemiology of prostate cancer  Develop abstracts and publishable manuscripts for peer-reviewed journals  Lecture on current and potential research projects

Research Associate – Cancer Risk Prediction & Prevention Program 2005 – 2012 Graduate Division Biological and Biomedical Sciences, Emory University, Atlanta, GA  Developed and evaluated biomarker expression in colorectal mucosa as potential modifiable, pre- neoplastic biomarkers of risk for colorectal neoplasms  Managed databases for multiple studies  Developed SAS programs for analyses of case-control studies and a clinical trial  Assisted in the collection of colorectal mucosa biopsies and processing of tissue samples with automated immunohistochemistry  Collaborated as a part of the Emory-Georgia Tech Nanotechnology Center for Personalized and Predictive Oncology on the development of Quantum Dot immunohistochemistry  Developed abstracts and publishable manuscripts for peer-reviewed journals

Research Associate – Georgia Cancer Cohort Study 2009 Department of Epidemiology, Emory University, Atlanta, GA  Participated in recruitment of study participants  Collected biological samples from study participants  Reviewed quality of data from food frequency questionnaires (FFQ)  Developed study proposal for validating FFQ in study cohort

Research Assistant – Division of Global Public Health Capacity Development 2004 – 2005 Center for Disease Control and Prevention, Atlanta, GA  Assisted in developing epidemiology training course material for the Field Epidemiology Training Program  Reviewed and edited epidemiology training course material for the Field Epidemiology Training Program

TEACHING EXPERIENCE Advisor – Cancer Risk Prediction & Prevention Program 2009 – 2012 Emory University, Atlanta, GA  Assist students with application of epidemiologic methods, nutritional and dietary concepts, and data analysis  Provide SAS programming instruction

Teaching Assistant - Diet and Chronic Disease 2008 Emory University, Atlanta, GA  Developed teaching plans and led a course lecture  Aided students with comprehending course material  Graded weekly assignments and Exams

Teaching Assistant Training and Teaching Opportunity Program 2008 Graduate School of Arts and Sciences, Emory University, Atlanta, GA

CIVIC SERVICE Americorps National Civilian Community Corps 2000 – 2001

AD HOC REVIEWER American Journal of Epidemiology Cancer Causes and Control

SCIENTIFIC MEMBERSHIPS American Association for Cancer Research 2010 – present

AWARDS 2010 Scientific Research and Academic Development Symposium 2010 Winship Cancer Institute, Emory University, Atlanta, GA  Outstanding Poster Presentation – Translational Research

Thomas U. Ahearn, Ph.D., M.P.H. C.V. Page 2 of 5 Rev. 03/2013 PUBLICATIONS Manuscripts Published in Peer-Reviewed Journals

Citronberg J, Bostick RM, Ahearn TU, Turgeon DK, Ruffin MT, Djuric Z, Sen A, Brenner DE, Zick SM. Effects of Ginger Supplementation on Cell-Cycle Biomarkers in the Normal-Appearing Colonic Mucosa of Patients at Increased Risk for Colorectal Cancer: Results from a Pilot, Randomized, and Controlled Trial. Cancer Prev Res (Phila), 2013.

Ahearn TU, Shaukat A, Flanders W, Rutherford RE, Bostick RM. A Randomized Clinical Trial of the Effects of Supplemental Calcium and Vitamin D3 on the APC/β-Catenin Pathway in the Normal Mucosa of Colorectal Adenoma Patients. Cancer Prevention Research, 2012. 5(10): p. 1247-1256.

Ahearn TU, McCullough M, Flanders W, Long Q, Sidelnikov E, Fedirko V, Daniel C, Rutherford R, Shaukat A,

Bostick R. A randomized clinical trial of supplemental calcium and vitamin D3 on markers of their metabolism in normal mucosa of colorectal adenoma patients. Cancer Res 2011; 71:413-23.

Ahearn TU, Shaukat A, Flanders W, Bostick R. Markers of the APC/β-catenin signaling pathway as potential treatable, pre-neoplastic biomarkers of risk for colorectal neoplasms. Cancer Epidemiol Biomarkers Prev 2012; 21(6): 969-979.

Chai W, Bostick RM, Ahearn TU, Franke AA, Custer LJ, Cooney RV. Effects of vitamin d(3) and calcium supplementation on serum levels of tocopherols, retinol, and specific vitamin d metabolites. Nutr Cancer, 2012. 64(1): p. 57-64.

Hopkins M, Owen J, Ahearn TU, Fedirko V, Flanders W, Dean P Jones, Bostick R. Effects of supplemental vitamin D and calcium on biomarkers of inflammation in colorectal adenoma patients: A randomized, controlled clinical trial. Cancer Prev Res 2011; 4(10): 1645-54.

Bostick RM, Kong KY, Ahearn TU, Chaudry Q, Cohen V, Wang MD. Detecting and quantifying biomarkers of risk for colorectal cancer using quantum dots and novel image analysis algorithms. Conf Proc IEEE Eng Med Biol Soc 2006; pp. 3313-3316.

Manuscripts in Preparation for Publication in Peer-Reviewed Journals

Tu H, Flanders W, Ahearn TU, Daniel C, Gonzalez-Feliciano A, Long Q, Rutherford RE, Bostick RM. Effects of Calcium and Vitamin D3 on TGFα and TGFβ1 Expression in Rectal Mucosa of Sporadic Colorectal Adenoma Patients: a Randomized Controlled Trial (Manuscript submitted to Carcinogenesis)

Shen H, Ahearn TU, Bostick RM. Effects of Calcium and Vitamin D Supplementation on Crypt Morphology in Normal Colon Mucosa: A Randomized Clinical Trial (Manuscript submitted to Cancer Epidemiol Biomarkers Prev)

PRESENTATIONS AND LECTURES Ahearn TU , Pettersson A, Stack EC,Ma J, Gerke T, Meisner A, Pollak MN, Finn S, Stampfer MJ, Loda M, Giovannucci EL, Mucci LA. The IGF/insulin signaling axis TMPRSS2:ERG and prostate cancer survival. In: American Association for Cancer Research Annual Meeting: Proceedings; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; 2013. Abstract nr LB-28.

Thomas U. Ahearn, Ph.D., M.P.H. C.V. Page 3 of 5 Rev. 03/2013 Shen H, Ahearn TU, Lipka S, Bostick RM. Effects of Calcium and Vitamin D Supplementation on Crypt Morphology in Normal Colon Mucosa: A Randomized Clinical Trial. AGA. Digestive Disease Week 2013 Meeting. Proceedings of the Annual Meeting of the American-Gastroenterological-Association. Orlando, FL, USA. 19-21 May 2013. Abstract nr 1586087

Tu H, Woodard J, Daniel C, Gonzalez-Feliciano A, Ahearn TU, Bostick RM. Markers of cell proliferation and growth as potential preneoplastic biomarkers of risk for colorectal neoplasms. In: American Association for Cancer Research Annual Meeting: Proceedings; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; 2013. Abstract nr 121.

Lakkur S, Ahearn TU, Roberd B. Effects of supplemental antioxidant micronutrients on oxidative DNA damage marker in normal colorectal mucosa: A randomized clinical trial. In: American Association for Cancer Research Annual Meeting: Proceedings; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; 2011. Abstract nr 1854.

Ahearn TU, McCullough M, Flanders W, Fedirko V, Rutherford R, Woodard J, Cohen V, Smith E, Bostick R.

Differences in supplemental calcium and vitamin D3 treatment effects on potential biomarkers of risk for colorectal neoplasms according to calcium receptor and vitamin D receptor expression. In: American Association for Cancer Research Annual Meeting: Proceedings; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; 2011. Abstract nr 842.

Effects of Calcium and Vitamin D on the Expression of the Vitamin D Receptor, CYP27B1, and CYP24A1 in Normal Colorectal Mucosa: A Randomized, Double-Blind, Placebo Controlled Clinical Trial. The Eighth Annual DSAC Research Symposium Graduate Division of Biological and Biomedical Sciences. Atlanta, GA, October 2010

Owen J, Ahearn TU, Liang B, Federiko V, Woodard J, Bostick R. Effects of supplemental calcium and vitamin D3 on serum growth factors in sporadic colorectal adenoma patients in a randomized clinical trial. In: American Association for Cancer Research Annual Meeting: Proceedings; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; 2010. Abstract nr 2895.

Ahearn TU, McCullough M, Flanders W, Long Q, Fung J, Ofori-Ado A, Dawadi S, Sidelnikov E, Bostick R. Effects of calcium and vitamin D on markers of vitamin D metabolism in normal colon mucosa: A randomized clinical trial. In: American Association for Cancer Research Annual Meeting: Proceedings; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; 2010. Abstract nr 2890.

Ahearn TU, McCullough M, Flanders W, Long Q, Sidelnikov E, Bostick R. Effects of calcium and vitamin D on the expression of the calcium sensing receptor, β-catenin, and E-cadherin in normal colorectal mucosa: A randomized, double-blind, placebo-controlled clinical trial. In: American Association for Cancer Research Annual Meeting: Proceedings; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 2996

Dash C, Ahearn TU, Shaukat A, Goodman M, Bostick R. High dietary iron levels and expression of Wnt pathway proteins in colon crypts of colorectal adenoma patients. In: American Association for Cancer Research Annual Meeting: Proceedings; 2008 Apr 12-16; San Diego, CA. Philadelphia (PA): AACR; 2008. Abstract nr 5504

Ahearn TU, Dash C, Bostick R. Associations of calcium and vitamin D with E-cadherin and β-catenin expression in normal-appearing rectal tissue; Markers of Adenomatous Polyps II (MAP II) case-control study. In: American Association for Cancer Research Annual Meeting: Proceedings; 2008 Apr 12-16; San Diego, CA. Philadelphia (PA): AACR; 2008. Abstract nr 565

Thomas U. Ahearn, Ph.D., M.P.H. C.V. Page 4 of 5 Rev. 03/2013 Ahearn TU, Shaukat-Bhatti A, Dash C, Bostick R. E-cadherin and APC expression in normal-appearing rectal mucosa between cases of incident, sporadic colorectal adenomatous polyps and healthy controls in the Markers of Adenomatous Polyp II (MAPII) case-control study. In: American Association for Cancer Research Annual Meeting: Proceedings; 2007 Apr 14-18; Los Angeles, CA. Philadelphia (PA): AACR; 2007. Abstract nr 1711

O’Regan R, Bostick R, Ahearn TU, Liu T, Yezhely M. Project 3: Use of conjugated quantum dots for multiplex detection of cancer-related biomarkers. NCI Nanotechnology Alliance Investigators Meeting Proceedings 2007; 95-97

Chaudry Q, Kong KY, Ahearn TU, Cohen V, Bostick RM, Wang MD. An integrated image quantification system for colorectal cancer risk assessment using quantum dots and molecular profiling. Proc IEEE Intl Symposium on Biomedical Imaging 2007; 1280-1283.

Bostick RM, Kong KY, Ahearn TU, Chaudry Q, Cohen V, Wang MD. Detecting and quantifying biomarkers of risk for colorectal cancer using quantum dots and novel image analysis algorithms. Conf Proc IEEE Eng Med Biol Soc 2006; pp. 3313-3316.

Thomas U. Ahearn, Ph.D., M.P.H. C.V. Page 5 of 5 Rev. 03/2013