Table S1. Differentially Expressed Genes Derived from the Comparison Analysis. Genes With

Table S1. Differentially expressed genes derived from the comparison analysis. Genes with changed expression in anx/anx mice compared with +/+ mice. The fold change is derived from the average ratio from MAS 5.0. Positive values of change indicate higher expression and negative values show lower expression in anx/anx mice.

Gene Symbol Entrez Gene Name ID Fold Change Ifit1l interferon-induced protein with tetratricopeptide repeats 1450783_at 13.277 1-like Oasl2 2'-5' oligoadenylate synthetase-like 2 1453196_a_at 10.676 Rtp4 receptor (chemosensory) transporter protein 4 1418580_at 9.375 Hla-c major histocompatibility complex, class I, C 1450170_x_at 7.482 Ifit3 interferon-induced protein with tetratricopeptide repeats 1449025_at 7.162 3 Usp18 ubiquitin specific peptidase 18 1418191_at 5.631 Stat1 signal transducer and activator of transcription 1, 91kDa 1450034_at 5.591 Ifi44 interferon-induced protein 44 1423555_a_at 5.328 Stat1 signal transducer and activator of transcription 1, 91kDa 1420915_at 5.183 Iigp1 interferon inducible GTPase 1 1419043_a_at 5.117 Ifih1 interferon induced with helicase C domain 1 1426276_at 4.581 Gbp4 guanylate binding protein 4 1418392_a_at 4.443 (includes eg:115361) Trim30 tripartite motif-containing 30 1451860_a_at 4.252 Rsad2 radical S-adenosyl methionine domain containing 2 1436058_at 4.164 Ifi47 interferon gamma inducible protein 47 1417292_at 3.662 Trim30 tripartite motif-containing 30 1417961_a_at 3.507 Trim25 tripartite motif-containing 25 1419879_s_at 3.318 B2m beta-2-microglobulin 1452428_a_at 3.259 Parp12 poly (ADP-ribose) polymerase family, member 12 1426774_at 3.094 B2m beta-2-microglobulin 1449289_a_at 3.063 Trim25 tripartite motif-containing 25 1425974_a_at 3.059 Gfap glial fibrillary acidic protein 1440142_s_at 2.781 C1qb complement component 1, q subcomponent, B chain 1437726_x_at 2.772 Pdap1 PDGFA associated protein 1 1434020_at 2.367 1435858_at 2.295 Ctss cathepsin S 1448591_at 2.280 C1orf86 chromosome 1 open reading frame 86 1438154_x_at 2.201 Hnrnpab heterogeneous nuclear ribonucleoprotein A/B 1426114_at 2.184 Ywhaz tyrosine 3-monooxygenase/tryptophan 5- 1436981_a_at 2.168 monooxygenase activation protein, zeta polypeptide 2810026p18rik RIKEN cDNA 2810026P18 gene 1428529_at 2.165 Pim3 pim-3 oncogene 1437100_x_at 2.149 Cotl1 Coactosin-like 1 (Dictyostelium) (Cotl1), mRNA 1437811_x_at 2.146 Zc3hav1 zinc finger CCCH-type, antiviral 1 1436183_at 2.135 Nucks1 nuclear casein kinase and cyclin-dependent kinase 1444952_a_at 2.069 substrate 1 Bcl2l11 BCL2-like 11 (apoptosis facilitator) 1456005_a_at 2.057 Atf4 activating transcription factor 4 (tax-responsive 1438992_x_at 1.987 enhancer element B67) Hmgb1l1 high-mobility group box 1-like 1 1439463_x_at 1.978 1810026b05rik RIKEN cDNA 1810026B05 gene 1447923_at 1.959 Krtcap2 keratinocyte associated protein 2 1417058_a_at 1.911 Snhg8 small nucleolar RNA host gene 8 1447896_s_at 1.899 (includes eg:69895) Morf4l1 mortality factor 4 like 1 1437801_at 1.884 Clic6 chloride intracellular channel 6 1454866_s_at 1.878 Znf498 zinc finger protein 498 1436606_at 1.872 Bbox1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1419618_at 1.868 (gamma-butyrobetaine hydroxylase) 1 Ttc13 tetratricopeptide repeat domain 13 1438631_x_at 1.863 Snord22 small nucleolar RNA, C/D box 22 1439399_a_at 1.852 (includes eg:9304) Rps27 ribosomal protein S27 1415716_a_at 1.851 Rhou ras homolog gene family, member U 1449027_at 1.842 1460070_at 1.841 Ctxn2 cortexin 2 1436493_at 1.837 (includes eg:381418) Bud31 BUD31 homolog (yeast) 1439466_s_at 1.803 (includes eg:231889) Sin3b SIN3 homolog B, transcription regulator (yeast) 1455039_a_at 1.798 Reep5 receptor accessory protein 5 1438001_x_at 1.783 Ncrna00081 non-protein coding RNA 81 1456393_at 1.775 Eid1 EP300 interacting inhibitor of differentiation 1 1448405_a_at 1.772 Rpl23 ribosomal protein L23 1454859_a_at 1.762 Gstm5 glutathione S-transferase mu 5 1448330_at 1.756 Rpl14 ribosomal protein L14 1438626_x_at 1.754 Shisa5 shisa homolog 5 (Xenopus laevis) 1437503_a_at 1.747 Hadh hydroxyacyl-Coenzyme A dehydrogenase 1455972_x_at 1.743 C1orf86 chromosome 1 open reading frame 86 1456310_a_at 1.729 Loc100131863 ribosomal protein S18 pseudogene 5 1455572_x_at 1.717 Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase 1437341_x_at 1.707 Sod1 superoxide dismutase 1, soluble 1459976_s_at 1.700 Rnf217 ring finger protein 217 1440179_x_at 1.692 Npc2 Niemann-Pick disease, type C2 1448513_a_at 1.687 Sepw1 selenoprotein W, 1 1460561_x_at 1.666 Rps13 ribosomal protein S13 1438794_x_at 1.666 Rps29 ribosomal protein S29 1438859_x_at 1.664 C16orf54 chromosome 16 open reading frame 54 1433465_a_at 1.663 Ndufa5 NADH dehydrogenase (ubiquinone) 1 alpha 1417285_a_at 1.658 subcomplex, 5, 13kDa Csnk1d casein kinase 1, delta 1437690_x_at 1.657 Cstb cystatin B (stefin B) 1422506_a_at 1.655 Psma6 proteasome (prosome, macropain) subunit, alpha type, 6 1437144_x_at 1.651 Rps29 ribosomal protein S29 1437413_x_at 1.650 Vamp3 vesicle-associated membrane protein 3 (cellubrevin) 1437708_x_at 1.650 Cox6a1 cytochrome c oxidase subunit VIa polypeptide 1 1417417_a_at 1.645 Gpsm1 G-protein signaling modulator 1 (AGS3-like, C. elegans) 1436917_s_at 1.644 Ubb ubiquitin B 1435643_x_at 1.640 Ubb ubiquitin B 1453723_x_at 1.636 Rpl37 ribosomal protein L37 1434872_x_at 1.636 Rps14 ribosomal protein S14 1436586_x_at 1.633 Eif3e eukaryotic translation initiation factor 3, subunit E 1439268_x_at 1.630 H2afz H2A histone family, member Z 1438091_a_at 1.625 Hint1 histidine triad nucleotide binding protein 1 1424017_a_at 1.622 Rps28 ribosomal protein S28 1454778_x_at 1.618 Cox4i1 cytochrome c oxidase subunit IV isoform 1 1448322_a_at 1.616 Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1436715_s_at 1.616 (phosphatidylinositol synthase) Pabpn1 poly(A) binding protein, nuclear 1 1422849_a_at 1.612 Rps28 ribosomal protein S28 1423763_x_at 1.606 Xpo7 exportin 7 1439411_a_at 1.604 Eif3e eukaryotic translation initiation factor 3, subunit E 1434523_x_at 1.604 Egr1 early growth response 1 1417065_at 1.600 Mbp myelin basic protein 1436201_x_at 1.592 Rps28 ribosomal protein S28 1451101_a_at 1.587 Ubb ubiquitin B 1449436_s_at 1.587 Rps20 ribosomal protein S20 1456436_x_at 1.587 Znf622 zinc finger protein 622 1438000_x_at 1.585 Rps14 ribosomal protein S14 1437706_x_at 1.575 Psmb3 proteasome (prosome, macropain) subunit, beta type, 3 1460198_a_at 1.572 Mbp myelin basic protein 1456228_x_at 1.572 Ndn necdin homolog (mouse) 1455792_x_at 1.571 Pdk1 pyruvate dehydrogenase kinase, isozyme 1 1423747_a_at 1.571 Derl1 Der1-like domain family, member 1 1437723_s_at 1.570 Timm17b translocase of inner mitochondrial membrane 17 1438656_x_at 1.568 homolog B (yeast) Arpc5l actin related protein 2/3 complex, subunit 5-like 1436421_s_at 1.566 (includes eg:81873) Limd2 LIM domain containing 2 1456377_x_at 1.566 C10orf58 chromosome 10 open reading frame 58 1447774_x_at 1.565 Loc388344 ribosomal protein L13 pseudogene 12 1460581_a_at 1.561 Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1416624_a_at 1.560 1 Taf9 TAF9 RNA polymerase II, TATA box binding protein 1438250_s_at 1.557 (TBP)-associated factor, 32kDa Snrpn small nuclear ribonucleoprotein polypeptide N 1415896_x_at 1.556 Bex1 brain expressed, X-linked 1 1448595_a_at 1.555 Morf4l1 mortality factor 4 like 1 1455077_a_at 1.554 Txnl1 thioredoxin-like 1 1436947_a_at 1.552 Sypl1 synaptophysin-like 1 1422881_s_at 1.549 Vps37c vacuolar protein sorting 37 homolog C (S. cerevisiae) 1437615_s_at 1.549 Rbbp7 retinoblastoma binding protein 7 1456227_x_at 1.546 Sod1 superoxide dismutase 1, soluble 1451124_at 1.544 Rpl14 ribosomal protein L14 1438507_x_at 1.544 Tbca tubulin folding cofactor A 1456205_x_at 1.542 Ndn necdin homolog (mouse) 1437853_x_at 1.541 Rpl18a ribosomal protein L18a 1428152_a_at 1.540 Rnf103 ring finger protein 103 1443830_x_at 1.539 Srp14 signal recognition particle 14kDa (homologous Alu 1454615_x_at 1.538 RNA binding protein) Cox5b cytochrome c oxidase subunit Vb 1435613_x_at 1.534 Cfl1 cofilin 1 (non-muscle) 1455138_x_at 1.533 Pa2g4 proliferation-associated 2G4, 38kDa 1420142_s_at 1.529 Rpl39 ribosomal protein L39 1450840_a_at 1.529 Prdx1 peroxiredoxin 1 1434731_x_at 1.524 Glo1 glyoxalase I 1451240_a_at 1.523 Cox5b cytochrome c oxidase subunit Vb 1456588_x_at 1.522 Cox6c cytochrome c oxidase subunit VIc 1434491_a_at 1.521 Mt1e metallothionein 1E 1428942_at 1.520 Csf1r colony stimulating factor 1 receptor 1419872_at 1.518 Fkbp1a FK506 binding protein 1A, 12kDa 1438958_x_at 1.515 Fam107a family with sequence similarity 107, member A 1434202_a_at 1.515 Dtymk deoxythymidylate kinase (thymidylate kinase) 1438096_a_at 1.514 Rps20 ribosomal protein S20 1456373_x_at 1.514 Fabp5 fatty acid binding protein 5 (psoriasis-associated) 1416021_a_at 1.513 Tbca tubulin folding cofactor A 1437907_a_at 1.511 Rpl31 ribosomal protein L31 1460008_x_at 1.504 Srp14 signal recognition particle 14kDa (homologous Alu 1455939_x_at 1.503 RNA binding protein) Ndufc2 NADH dehydrogenase (ubiquinone) 1, subcomplex 1455036_s_at 1.503 unknown, 2, 14.5kDa Dynlt3 dynein, light chain, Tctex-type 3 1459854_s_at 1.501 Lamp1 lysosomal-associated membrane protein 1 1415880_a_at 1.490 Rps6 ribosomal protein S6 1455693_x_at 1.488 C1qbp complement component 1, q subcomponent binding 1455821_x_at 1.481 protein Snrpn small nuclear ribonucleoprotein polypeptide N 1415895_at 1.480 Sumo2 SMT3 suppressor of mif two 3 homolog 2 (yeast) 1415781_a_at 1.480 (includes eg:170930) Fbxw11 F-box and WD repeat domain containing 11 1437468_x_at 1.476 Wdr6 WD repeat domain 6 1455940_x_at 1.475 (includes eg:11180) Ints5 integrator complex subunit 5 1434011_a_at 1.473 Hk1 hexokinase 1 1436822_x_at 1.471 Ptp4a1 protein tyrosine phosphatase type IVA, member 1 1438657_x_at 1.470 Cttn cortactin 1433908_a_at 1.467 Gja1 gap junction protein, alpha 1, 43kDa 1437992_x_at 1.467 Med20 mediator complex subunit 20 1416826_a_at 1.457 Rpl26 ribosomal protein L26 1436995_a_at 1.455 Fkbp1a FK506 binding protein 1A, 12kDa 1456196_x_at 1.453 Armcx2 armadillo repeat containing, X-linked 2 1456739_x_at 1.449 Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 1428161_a_at 1.448 Hspc159 galectin-related protein 1451313_a_at 1.443 Rpl14 ribosomal protein L14 1436688_x_at 1.438 Cox17 COX17 cytochrome c oxidase assembly homolog (S. 1434435_s_at 1.437 cerevisiae) Rps12 ribosomal protein S12 1433432_x_at 1.430 (includes eg:20042) Rps21 ribosomal protein S21 1434358_x_at 1.421 Morf4l2 mortality factor 4 like 2 1456743_x_at 1.421 Gdi2 GDP dissociation inhibitor 2 1436016_x_at 1.410 Cyb5r4 cytochrome b5 reductase 4 1426307_at -1.422 Gnal guanine nucleotide binding protein (G protein), alpha 1439957_at -1.428 activating activity polypeptide, olfactory type Gpd2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) 1428323_at -1.433 Aldh7a1 aldehyde dehydrogenase 7 family, member A1 1460167_at -1.448 Calml4 calmodulin-like 4 1424713_at -1.449 Glrb glycine receptor, beta 1422504_at -1.450 C13orf30 chromosome 13 open reading frame 30 1458500_at -1.453 Pak3 p21 protein (Cdc42/Rac)-activated kinase 3 1437318_at -1.471 Lpgat1 lysophosphatidylglycerol acyltransferase 1 1424350_s_at -1.474 Magi3 membrane associated guanylate kinase, WW and PDZ 1435461_at -1.475 domain containing 3 Np nucleoside phosphorylase 1453299_a_at -1.486 1700020i14rik RIKEN cDNA 1700020I14 gene 1428411_at -1.495 Tpm4 tropomyosin 4 1433883_at -1.498 Abcd2 ATP-binding cassette, sub-family D (ALD), member 2 1456812_at -1.499 Slc13a3 solute carrier family 13 (sodium-dependent 1438377_x_at -1.500 dicarboxylate transporter), member 3 Gabrb2 gamma-aminobutyric acid (GABA) A receptor, beta 2 1429685_at -1.502 Vma21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) 1434233_at -1.504 Cxcl12 chemokine (C-X-C motif) ligand 12 (stromal cell- 1448823_at -1.510 derived factor 1) Rps6ka6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 1429759_at -1.515 Lgals1 lectin, galactoside-binding, soluble, 1 1455439_a_at -1.527 Fyttd1 forty-two-three domain containing 1 1424342_at -1.529 Tm9sf2 transmembrane 9 superfamily member 2 1460331_at -1.544 Meg3 maternally expressed 3 1428764_at -1.547 (includes eg:17263) 2610203c20rik RIKEN cDNA 2610203C20 gene 1455160_at -1.548 Map2k4 mitogen-activated protein kinase kinase 4 1426233_at -1.550 Grm3 glutamate receptor, metabotropic 3 1430136_at -1.552 Anxa5 annexin A5 1425567_a_at -1.554 Mapk6 mitogen-activated protein kinase 6 1419169_at -1.558 Heatr5b HEAT repeat containing 5B 1439815_at -1.564 Meg3 maternally expressed 3 1426758_s_at -1.564 (includes eg:17263) 1457743_at -1.574 Cds1 CDP-diacylglycerol synthase (phosphatidate 1428680_at -1.582 cytidylyltransferase) 1 Cartpt CART prepropeptide 1422825_at -1.589 Itfg1 integrin alpha FG-GAP repeat containing 1 1419041_at -1.596 Tmtc4 transmembrane and tetratricopeptide repeat containing 4 1428113_at -1.599 Hspa4l heat shock 70kDa protein 4-like 1449010_at -1.612 Lman2l lectin, mannose-binding 2-like 1435475_at -1.617 1439093_at -1.653 Bmper BMP binding endothelial regulator 1429273_at -1.681 Rab6b RAB6B, member RAS oncogene family 1460617_s_at -1.686 Tnfaip8 tumor necrosis factor, alpha-induced protein 8 1416950_at -1.689 Ppargc1a peroxisome proliferator-activated receptor gamma, 1460336_at -1.694 coactivator 1 alpha Crtap cartilage associated protein 1448592_at -1.715 Tubb2c tubulin, beta 2C 1423642_at -1.716 Rgmb RGM domain family, member B 1433587_at -1.745 Ttc14 tetratricopeptide repeat domain 14 1437878_s_at -1.754 Klf12 Kruppel-like factor 12 1439846_at -1.782 Ccdc132 coiled-coil domain containing 132 1432094_a_at -1.787 Ttc14 tetratricopeptide repeat domain 14 1426544_a_at -1.794 Dnm3 dynamin 3 1436875_at -1.795 Cnot4 CCR4-NOT transcription complex, subunit 4 1420999_at -1.848 Napb N-ethylmaleimide-sensitive factor attachment protein, 1427470_s_at -1.867 beta Samd5 sterile alpha motif domain containing 5 1437403_at -1.876 Tubb3 tubulin, beta 3 1415978_at -1.889 Pla2g7 phospholipase A2, group VII (platelet-activating factor 1430700_a_at -1.911 acetylhydrolase, plasma) Hspa4l heat shock 70kDa protein 4-like 1418253_a_at -1.915 Dzip3 DAZ interacting protein 3, zinc finger 1444058_at -1.945 Snx27 sorting nexin family member 27 1430037_at -1.950 Dio2 deiodinase, iodothyronine, type II 1418937_at -1.965 Lasp1 LIM and SH3 protein 1 1460173_at -1.969 Tacr3 tachykinin receptor 3 1437029_at -2.058 Rpap1 RNA polymerase II associated protein 1 1426890_a_at -2.093 Enpp5 ectonucleotide pyrophosphatase/phosphodiesterase 5 1425702_a_at -2.116 (putative function) Slc1a2 solute carrier family 1 (glial high affinity glutamate 1439940_at -2.129 transporter), member 2 Cck cholecystokinin 1419473_a_at -2.182 Atp5f1 ATP synthase, H+ transporting, mitochondrial F0 1426742_at -2.187 complex, subunit B1 Ndufaf1 NADH dehydrogenase (ubiquinone) 1 alpha 1423711_at -2.220 subcomplex, assembly factor 1 Hsph1 heat shock 105kDa/110kDa protein 1 1423566_a_at -2.229 Kiaa0368 KIAA0368 1452122_at -2.231 Morn5 MORN repeat containing 5 1452804_at -2.274 Hspa12a heat shock 70kDa protein 12A 1434051_s_at -2.281 Selt selenoprotein T 1453726_s_at -2.312 Fstl1 follistatin-like 1 1448259_at -2.322 Col3a1 collagen, type III, alpha 1 1427883_a_at -2.412 Plcxd2 phosphatidylinositol-specific phospholipase C, X 1435462_at -2.602 domain containing 2 Hbd hemoglobin, delta 1417184_s_at -2.628 Rlbp1 retinaldehyde binding protein 1 1418310_a_at -2.738 Igfbp4 insulin-like growth factor binding protein 4 1423756_s_at -2.788 Uba6 ubiquitin-like modifier activating enzyme 6 1428944_at -2.917 Rgs5 regulator of G-protein signaling 5 1420941_at -2.990 Oprm1 MOR mRNA for mu opioid receptor 1441791_at -3.190 Serpinh1 serpin peptidase inhibitor, clade H (heat shock protein 1450843_a_at -3.236 47), member 1, (collagen binding protein 1) Shox2 short stature homeobox 2 1438042_at -3.529 Hba2 hemoglobin, alpha 2 1452757_s_at -3.656