Addional Data File 1 Diabetes Regulated Genes

Addional data file 1

Diabetes regulated genes in peripheral blood cells

Fold change Accession Gene Name Cytogenetic T2D T2DN T2DN vs. Broad Function ID (Annotated January 14, 2004) Position vs. C vs. C T2D

AA043551 UDP-GlcNAc:betaGal beta-1,3-N- 3q28 2.05 -4.29 -8.77 enzyme acetylglucosaminyltransferase 5 H29513 hypothetical protein FLJ10193 17p11.2 4.11 -1.59 -6.52 N91101 EST 3.52 -1.59 -5.61 AA456156 uroporphyrinogen III synthase (congenital 10q25.2- 4.09 -1.20 -4.91 enzyme erythropoietic porphyria) q26.3 H65231 EST 4.25 -1.09 -4.63 W76331 leukotriene B4 12-hydroxydehydrogenase 9q32 4.70 1.02 -4.60 enzyme H54629 tumor necrosis factor (ligand) superfamily, 3q26 4.28 -1.06 -4.54 signal transducer member 10 W95626 EST 1.95 -2.30 -4.50 AA424575 hematopoietic cell-specific Lyn substrate 1 3q13 4.93 1.10 -4.47 nucleic acid binding W95480 similar to RIKEN cDNA 2310038H17 13q33.1 4.58 1.07 -4.29 W80591 hepatocellular carcinoma-associated antigen 9q34.2 2.76 -1.38 -3.81 59 AA487681 ornithine decarboxylase antizyme 1 19p13.3 3.30 -1.11 -3.68 enzyme inhibitor R22065 Homo sapiens transcribed sequences 1.52 -2.40 -3.66 AA132094 down-regulator of transcription 1, TBP- 1p22.1 3.63 1.02 -3.55 nucleic acid binding binding (negative cofactor 2) H20442 hypothetical protein FLJ20507 2q11.2 1.85 -1.89 -3.50 AA056734 KIAA1110 protein 12p13.33 3.34 -1.04 -3.46 AA130671 stromal cell derived factor receptor 1 15q22 2.11 -1.62 -3.41 AA192419 biliverdin reductase A 7p14-cen 3.14 -1.08 -3.40 enzyme R54105 dihydropyrimidinase-like 5 2p23.3 2.25 -1.48 -3.34 N23112 protein kinase, AMP-activated, alpha 1 5p12 2.36 -1.39 -3.28 enzyme catalytic subunit AA487262 hypothetical protein MGC20235 17q21.31 2.58 -1.27 -3.28 AA401853 proteasome (prosome, macropain) 26S 12q24.31- 3.55 1.11 -3.20 ligand binding or subunit, non-ATPase, 9 q24.32 carrier R99220 like mouse brain protein E46 22q13.31 2.36 -1.34 -3.17 unknown H57273 EST 2.74 -1.14 -3.11 W04713 transcription factor RAM2 7p15.3 1.59 -1.95 -3.09 T54164 EST 2.15 -1.39 -2.98 AA453202 nuclear receptor subfamily 1, group D, 17q11.2 2.84 -1.05 -2.98 nucleic acid binding member 1 W95076 Homo sapiens transcribed sequences 2.45 -1.21 -2.96 H55907 GrpE-like 1, mitochondrial (E. coli) 4p16 3.82 1.29 -2.96 chaperone H22568 solute carrier family 36 (proton/amino acid 11q14.3 2.04 -1.44 -2.94 symporter), member 4 AA410383 chemokine (C-X-C motif) ligand 13 (B-cell 4q21 1.95 -1.49 -2.90 signal transducer chemoattractant) AA436372 zinc finger protein 151 (pHZ-67) 1p36.2- 3.17 1.10 -2.87 ligand binding or p36.1 carrier W74657 Kruppel-like factor 2 (lung) 19p13.13- 1.94 -1.47 -2.86 nucleic acid binding p13.11 AA180453 EST 1.60 -1.77 -2.83 AA174088 Homo sapiens transcribed sequences 2.73 -1.04 -2.83 H79353 Fc fragment of IgE, high affinity I, receptor 1q23 3.37 1.22 -2.75 signal transducer for; gamma polypeptide AA173888 Homo sapiens transcribed sequence with weak 1.74 -1.54 -2.68 similarity to protein ref:NP_060312 AA070487 hypothetical protein MGC34132 3p14.2 2.06 -1.29 -2.66 H91216 Homo sapiens histone 1, H2ac, mRNA (cDNA clone 2.79 1.06 -2.63 IMAGE:6526471), partial cds R33841 EST 2.28 -1.15 -2.62 AA411900 Mov10l1, Moloney leukemia virus 10-like 1, 22q13.33 -1.07 -2.79 -2.62 homolog (mouse) AA055807 Homo sapiens transcribed sequences 1.86 -1.39 -2.60 H68845 peroxiredoxin 2 19p13.2 2.40 -1.08 -2.58 enzyme W57767 similar to ENSANGP00000010412 1p34.1 1.28 -2.00 -2.56 R38300 EST 2.18 -1.17 -2.55 R93875 nucleosome assembly protein 1-like 1 12q21.1 2.95 1.16 -2.54 R37411 guanine deaminase 9q21.11- 1.29 -1.93 -2.49 21.33 H85355 EST 1.29 -1.91 -2.47 H20570 KIAA1391 protein 11q23.2 1.75 -1.41 -2.46 AA599078 signal recognition particle 54kDa 14q13.2 2.06 -1.20 -2.46 ligand binding or carrier R66235 EST 1.65 -1.48 -2.43 AA461492 similar to fibrillar collagen precursor 5q33.1 2.25 -1.08 -2.43 AA447598 Homo sapiens transcribed sequences 2.13 -1.13 -2.42 AA453925 KIAA0157 protein 10q26.2 1.96 -1.22 -2.39 AA490771 UV radiation resistance associated gene 11q13.5 2.89 1.21 -2.39 R06378 Homo sapiens clone DT1P1B6 mRNA, CAG repeat 1.87 -1.28 -2.39 region N48080 G-protein coupled receptor 88 1p21.3 1.49 -1.57 -2.34 signal transducer N40202 Homo sapiens transcribed sequences 1.73 -1.34 -2.32 AA521389 tumor protein p53 binding protein, 1 15q15- 1.45 -1.59 -2.30 ligand binding or q21 carrier W72231 x 006 protein 17p13.1 2.21 -1.04 -2.29 H71314 EST -1.02 -2.35 -2.29 AA182680 ubiquitin specific protease 9, Y-linked (fat Yq11.2 1.56 -1.47 -2.28 enzyme facets-like, Drosophila) R01272 hypothetical protein FLJ20618 22q12.2 1.95 -1.17 -2.28 N47954 hippocalcin like 4 1p34.2 1.87 -1.22 -2.27 T88816 EST -1.02 -2.32 -2.27 R25825 N-acetylgalactosaminidase, alpha- 22q13- 1.66 -1.36 -2.25 enzyme qter AA056580 44050 protein 10q24.2 1.84 -1.22 -2.25 N24157 chromosome 6 open reading frame 35 6q25.3 2.17 -1.04 -2.25 H48677 caldesmon 1 7q33 2.75 1.22 -2.25 R95913 chromosome 14 open reading frame 117 14q24.2 1.29 -1.73 -2.23 H18433 Homo sapiens transcribed sequences 1.01 -2.18 -2.21 H16637 vascular cell adhesion molecule 1 1p32-p31 1.77 -1.24 -2.20 cell adhesion AA676749 dual-specificity tyrosine-(Y)-phosphorylation 21q22.13 1.56 -1.41 -2.20 enzyme regulated kinase 1A AA421266 WD repeat domain 5 9q34 1.40 -1.55 -2.18 AA004816 Homo sapiens clone ZI25H08 mRNA sequence 1.37 -1.59 -2.18 H78182 EST 1.39 -1.57 -2.18 AA416984 hypothetical protein MGC27085 3q26.31 1.83 -1.19 -2.16 AA454880 EST 1.96 -1.11 -2.16 N66068 ubiquitin specific protease 42 7p22.2 1.94 -1.11 -2.16 enzyme H66005 Homo sapiens transcribed sequences -1.06 -2.29 -2.16 N73201 EST 1.52 -1.42 -2.15 T41149 heterogeneous nuclear ribonucleoprotein R 1p36.11 1.39 -1.54 -2.15 nucleic acid binding W35203 chitobiase, di-N-acetyl- 1p22 1.88 -1.14 -2.14 W72621 RING1 and YY1 binding protein 3p14.2 1.93 -1.11 -2.14 transcription factor binding W67228 Homo sapiens transcribed sequence with weak 1.21 -1.76 -2.13 similarity to protein ref:NP_060312 H85454 potassium voltage-gated channel, delayed- 20q12 -1.06 -2.25 -2.13 ligand binding or rectifier, subfamily S, member 1 carrier AA456595 hypothetical protein MGC12904 9q33.1 1.96 -1.08 -2.12 AA476221 hypothetical protein FLJ30932 19p13.2 1.85 -1.14 -2.11 nucleic acid binding AA634028 major histocompatibility complex, class II, 6p21.3 1.17 -1.80 -2.10 DP alpha 1 AA454165 zinc finger protein, X-linked Xp21.3 1.49 -1.40 -2.09 nucleic acid binding R56219 cadherin 8, type 2 16q22.1 1.92 -1.09 -2.09 cell adhesion N66591 retinoblastoma binding protein 6 16p12.2 1.36 -1.53 -2.08 ligand binding or carrier AA443557 protocadherin 1 (cadherin-like 1) 5q32-q33 2.38 1.15 -2.07 T83098 adducin 2 (beta) 2p14-p13 2.11 1.02 -2.07 ligand binding or carrier AA451781 dynactin 6 8p12-p11 1.41 -1.47 -2.07 enzyme AA490902 guanylate kinase 1 1q32-q41 2.44 1.18 -2.07 enzyme R58974 EST 1.06 -1.95 -2.06 R47893 chemokine (C-C motif) ligand 3-like 1 17q21.1- 1.13 -1.83 -2.06 q21.3 W00946 hypothetical protein MGC7036 12q24.31 1.44 -1.42 -2.05 AA398949 PCTAIRE protein kinase 3 1q31-q32 1.54 -1.33 -2.05 N47208 hypothetical protein MGC24995 1p32.3 1.74 -1.17 -2.04 AA448641 E2F transcription factor 4, p107/p130- 16q21- 1.22 -1.67 -2.04 nucleic acid binding binding q22 R80235 Mdm2, transformed 3T3 cell double minute 12q14.3- 1.12 -1.82 -2.03 2, p53 binding protein (mouse) q15 N73278 Homo sapiens mRNA; cDNA DKFZp586I1823 (from 1.25 -1.63 -2.03 clone DKFZp586I1823) AA608988 testis specific protein, Y-linked Yp11.2 1.19 -1.71 -2.03 R16838 cytochrome P450, family 17, subfamily A, 10q24.3 1.72 -1.18 -2.03 enzyme polypeptide 1 H21074 Homo sapiens clone 24626 mRNA sequence 1.27 -1.60 -2.03 AA459572 protein phosphatase 1, regulatory subunit 7 2q37.3 1.86 -1.09 -2.02 enzyme AA034183 hypothetical protein FLJ23027 14q32.32 1.31 -1.54 -2.02 H42037 Homo sapiens full length insert cDNA YO61A08 1.35 -1.49 -2.01 N49526 v-myb myeloblastosis viral oncogene 6q22-q23 1.57 -1.28 -2.01 homolog (avian) AA487192 Homo sapiens, clone IMAGE:3453158, mRNA 1.99 -1.01 -2.01 AA453991 hypothetical protein MGC3222 3p25.1 1.74 -1.15 -2.01 T90767 cyclin T1 12pter- 1.57 -1.28 -2.00 qter T63981 hypothetical protein MGC16202 10q23.33 1.39 -1.44 -2.00 AA676590 telomeric repeat binding factor 2 16q22.1 1.64 -1.22 -2.00 AA455126 ATP synthase, H+ transporting, 12q13.13 1.14 -1.75 -2.00 ligand binding or mitochondrial F0 complex, subunit c carrier (subunit 9), AA127234 psoriasis susceptibility 1 candidate 1 6p21.3 1.67 -1.20 -2.00 R01619 Homo sapiens transcribed sequence with moderate 2.18 1.11 -1.96 similarity to protein pir:E54024 H21520 rap2 interacting protein x 4q21.1 2.01 1.03 -1.94 H01039 Homo sapiens transcribed sequence with strong 3.26 1.68 -1.93 similarity to protein pir:A47501 ( AA485974 golgi autoantigen, golgin subfamily b, 3q13 2.30 1.20 -1.93 macrogolgin (with transmembrane signal), R22856 Homo sapiens transcribed sequence with weak -1.18 -2.25 -1.92 similarity to protein ref:NP_071431 N51290 Homo sapiens cDNA FLJ43343 fis, clone NT2RI3008055 -1.34 -2.56 -1.90 N51842 Homo sapiens cDNA FLJ10967 fis, clone -1.10 -2.09 -1.90 PLACE1000798. N52043 chromosome 6 open reading frame 65 6p12.1 -1.14 -2.15 -1.89 N47443 KIAA0390 gene product 19q13.11 2.03 1.08 -1.88 AA130193 acheron 15q22.32 2.67 1.42 -1.88 nucleic acid binding N63864 Homo sapiens transcribed sequences 2.01 1.08 -1.86 AA620669 Homo sapiens transcribed sequences -1.27 -2.34 -1.84 AA186686 prostaglandin E synthase 2 9q34.13 -1.20 -2.14 -1.79 ligand binding or carrier AA099855 popeye domain containing 2 3q13.33 -1.98 -3.52 -1.78 AA004803 Homo sapiens transcribed sequences -1.25 -2.19 -1.76 AA609332 Homo sapiens transcribed sequences -1.22 -2.11 -1.73 H70813 hypothetical protein FLJ11457 2q31.1 -1.42 -2.45 -1.72 W70051 M-phase phosphoprotein 9 12q24.31 2.00 1.21 -1.65 AA045342 hypothetical protein FLJ23047 3q12.3 -1.63 -2.66 -1.63 W45165 capping protein (actin filament) muscle Z- 1p36.1 2.04 1.29 -1.57 ligand binding or line, beta carrier AA029647 late envelope protein 3 1q21.3 -1.54 -2.41 -1.56 AA099404 hypothetical protein MGC22793 7q22.1 -1.36 -2.10 -1.55 N74052 Homo sapiens transcribed sequences -1.68 -2.61 -1.55 R00809 calcium channel, voltage-dependent, alpha 3p21.3 -1.35 -2.09 -1.54 2/delta subunit 2 AA497030 Homo sapiens transcribed sequences -1.42 -2.19 -1.54 AA026686 EST 2.28 1.48 -1.54 N22827 ferredoxin 1 11q22 -1.31 -2.02 -1.54 ligand binding or carrier N39408 cyclin-dependent kinase 5, regulatory 2q35 -1.43 -2.19 -1.53 subunit 2 (p39) AA663828 calmodulin 3 (phosphorylase kinase, delta) 19q13.2- 2.02 1.32 -1.53 ligand binding or q13.3 carrier AA464568 proteasome (prosome, macropain) 26S 19q13.11- -1.71 -2.58 -1.51 enzyme subunit, ATPase, 4 q13.13 AA460669 CDC26 subunit of anaphase promoting 9q32 -1.87 -2.81 -1.50 complex N48571 Homo sapiens full length insert cDNA clone YY74A01 2.04 1.36 -1.50 AA035347 glucosamine (N-acetyl)-6-sulfatase 12q14 2.27 1.55 -1.46 enzyme (Sanfilippo disease IIID) AA459868 Homo sapiens cDNA clone IMAGE:3453243 -2.77 -4.05 -1.46 AA431181 thyroid hormone receptor-associated 19p13.3 2.42 1.67 -1.45 transcription factor protein, 95-kD subunit binding AA401482 Homo sapiens, clone IMAGE:4821566, mRNA -1.43 -2.01 -1.41 H64601 interleukin 17 receptor B 3p21.1 -1.62 -2.27 -1.40 signal transducer AA432106 hypothetical protein FLJ11046 3q12.3 -1.44 -2.02 -1.40 AA164782 CocoaCrisp 8q13.3 -1.49 -2.08 -1.39 AA489028 squamous cell carcinoma antigen 12q24.1 -1.50 -2.08 -1.38 recognised by T cells 3 AA074079 Homo sapiens, clone IMAGE:5302006, mRNA -1.75 -2.41 -1.38 AA401438 Homo sapiens transcribed sequences -2.05 -2.81 -1.37 N78703 Homo sapiens transcribed sequence with weak -1.50 -2.04 -1.35 similarity to protein ref:NP_062553 W32296 Homo sapiens transcribed sequences -1.55 -2.08 -1.34 AA461092 RNA binding motif protein, X-linked Xq26 -2.06 -2.75 -1.34 nucleic acid binding H10995 Homo sapiens mRNA full length insert cDNA clone -1.67 -2.20 -1.32 EUROIMAGE 35907 N30704 EST -1.95 -2.56 -1.32 AA401437 KIAA1799 protein 1p31.3 -1.61 -2.09 -1.30 R76782 O-linked N-acetylglucosamine (GlcNAc) Xq13 -2.35 -2.98 -1.27 transferase (UDP-N- acetylglucosamine:polyp W67368 Homo sapiens transcribed sequence with weak -2.12 -2.66 -1.26 similarity to protein ref:NP_060312 H94739 putative MAPK activating protein 1p36.13 -2.11 -2.65 -1.26 PM20,PM21 AA481789 EST -1.80 -2.19 -1.22 AA459692 Homo sapiens transcribed sequences -1.89 -2.29 -1.21 AA463458 glutathione synthetase 20q11.2 2.02 1.68 -1.20 enzyme N69913 Homo sapiens cDNA FLJ42666 fis, clone -2.35 -2.77 -1.18 BRAMY2020050 H94944 v-ral simian leukemia viral oncogene 7p15-p13 -1.96 -2.30 -1.18 enzyme homolog A (ras related) AA004810 Homo sapiens transcribed sequences 2.36 2.03 -1.17 W69913 EST -2.44 -2.84 -1.16 N73846 Zinc finger, FYVE domain containing 19 15q14 -1.73 -2.01 -1.16 N90968 Homo sapiens transcribed sequences 2.18 1.90 -1.15 AA455146 acetyl-Coenzyme A synthetase 2 (ADP 20q11.23 -2.21 -2.50 -1.13 enzyme forming) AA192453 EST -1.87 -2.11 -1.13 N51883 Homo sapiens transcribed sequences 2.05 1.81 -1.13 AA429034 HGFL gene 22q12.2 2.32 2.06 -1.13 R96522 EST -1.88 -2.03 -1.08 AA460963 Homo sapiens transcribed sequence with strong -2.36 -2.53 -1.07 similarity to protein ref:NP_07897 AA609746 Homo sapiens transcribed sequences -1.96 -2.09 -1.07 T84703 Homo sapiens transcribed sequences 3.36 3.18 -1.06 AA443094 translocase of outer mitochondrial 19q13 2.03 1.93 -1.05 transporter membrane 40 homolog (yeast) AA488526 nucleolar and coiled-body phosphoprotein 1 10q24.32 2.03 1.95 -1.04 ligand binding or carrier W74216 peptidoglycan recognition protein-I-beta precursor -1.96 -2.02 -1.03 R92199 Homo sapiens transcribed sequence with weak -2.08 -2.12 -1.02 similarity to protein ref:NP_060265 AA025268 centaurin, beta 5 -2.61 -2.61 1.00 AA152178 neuron navigator 2 11p15.1 2.95 3.03 1.03 H48389 Homo sapiens transcribed sequences -2.25 -2.18 1.03 AA148200 TAF10 RNA polymerase II, TATA box binding 11p15.3 -2.19 -2.11 1.04 nucleic acid binding protein (TBP)-associated factor, 30kDa AA400412 RAD9 homolog B (S. cerevisiae) 12q24.13 -2.25 -2.06 1.09 AA401392 TAF7-like RNA polymerase II, TATA box Xq22.1 -2.33 -2.12 1.10 binding protein (TBP)-associated factor, 5 N22297 hypothetical protein FLJ90430 7q11.21 1.80 2.01 1.11 ligand binding or carrier AA489498 salvador homolog 1 (Drosophila) 14q13- -2.33 -2.07 1.12 q23 AA486104 proline synthetase co-transcribed homolog 8p11.2 -2.29 -2.03 1.13 unknown (bacterial) AA102634 TNF receptor-associated factor 5 1q32 -2.22 -1.91 1.16 ligand binding or carrier L06499 ribosomal protein L37a 2q35 -2.44 -2.09 1.17 nucleic acid binding AA621001 Homo sapiens transcribed sequences 4.64 5.49 1.18 AA136071 Homo sapiens transcribed sequences -2.31 -1.95 1.19 R87840 intercellular adhesion molecule 5, 19p13.2 1.93 2.30 1.19 telencephalin R53428 ATP-binding cassette, sub-family A (ABC1), 17q24.3 -2.07 -1.71 1.21 ligand binding or member 5 carrier R70174 ubiquitin specific protease 13 (isopeptidase 3q26.2- -3.40 -2.76 1.23 enzyme T-3) q26.3 R06321 hydroxymethylbilane synthase 11q23.3 1.94 2.39 1.24 enzyme AA088428 Homo sapiens transcribed sequences -2.13 -1.71 1.24 N72116 solute carrier family 11 (proton-coupled 12q13 -2.77 -2.20 1.26 transporter divalent metal ion transporters), membe AA453283 protocadherin beta 16 5q31 -2.80 -2.21 1.27 AA180455 EST -2.31 -1.80 1.28 N50770 esophageal cancer associated protein 16p13.11 1.62 2.08 1.28 R69790 hypothetical protein MGC4701 4p16.3 -2.20 -1.68 1.31 H88521 G protein-coupled receptor 48 11p14- -2.67 -1.98 1.35 p13 R41724 Homo sapiens transcribed sequences 1.49 2.06 1.38 H89664 amyloid beta (A4) precursor-like protein 2 11q23- 1.49 2.06 1.38 q25 N64009 KIAA1199 protein 15q -2.38 -1.71 1.39 R97788 Ring-box 1 22q13.2 -2.78 -2.01 1.39 enzyme AA620404 hypothetical protein LOC90850 16p13.3 -2.51 -1.78 1.41 AA496930 reversion-inducing-cysteine-rich protein 9p13-p12 -2.02 -1.43 1.42 enzyme inhibitor with kazal motifs R64066 Homo sapiens transcribed sequences -2.05 -1.45 1.42 AA013260 tribbles homolog 2 2p25.1 1.51 2.19 1.45 enzyme R39179 Spir-2 protein 16q24 -2.10 -1.44 1.45 N51068 Homo sapiens cDNA FLJ42364 fis, clone -2.01 -1.38 1.46 UTERU2027591, moderately similar to Human AA608770 Homo sapiens transcribed sequence -2.19 -1.49 1.47 W61116 mitogen-activated protein kinase kinase 17q21 -2.02 -1.32 1.53 enzyme kinase 14 AA187595 Ring finger protein 3 4p16.3 -2.25 -1.47 1.53 AA447480 ARG99 protein 12p11.23 -2.01 -1.29 1.56 R07897 EST 1.34 2.11 1.57 AA609348 KIAA1576 protein 16q23.1 -2.37 -1.47 1.61 enzyme AA457501 cytochrome b reductase 1 2q31.1 -2.45 -1.52 1.61 T98662 ribosomal protein S25 11q23.3 1.52 2.47 1.62 nucleic acid binding AA058314 lectin, galactoside-binding, soluble, 3 14q21- 1.35 2.18 1.62 ligand binding or (galectin 3) q22 carrier AA450062 prostate differentiation factor 19p13.1- 1.29 2.10 1.62 13.2 AA169724 protein arginine N-methyltransferase 6 1p13.3 2.00 3.24 1.62 enzyme AA165208 Homo sapiens transcribed sequences -2.09 -1.28 1.64 AA169807 Homo sapiens cDNA FLJ42602 fis, clone 1.26 2.08 1.65 BRACE3011271, moderately similar to Patch N21546 topoisomerase (DNA) III alpha 17p12- 1.30 2.18 1.67 enzyme 17p11.2 AA133566 general transcription factor IIE, polypeptide 8p21-p12 1.20 2.04 1.69 nucleic acid binding 2, beta 34kDa AA164712 FLJ00166 protein 3q27.2 -2.34 -1.38 1.70 AA453859 alcohol dehydrogenase 5 (class III), chi 4q21-q25 1.22 2.09 1.71 enzyme polypeptide AA401111 glucose phosphate isomerase 19q13.1 1.35 2.32 1.72 enzyme AA609304 Homo sapiens transcribed sequence with weak -2.03 -1.18 1.73 similarity to protein ref:NP_060312 AA045481 RAP2C, member of RAS oncogene family Xq25 1.29 2.23 1.73 enzyme T56874 UPF2 regulator of nonsense transcripts 10p14- -2.07 -1.20 1.73 nucleic acid binding homolog (yeast) p13 W32523 signal recognition particle 72kDa 4q11 -2.05 -1.18 1.74 AA137266 nuclear ubiquitous casein kinase and cyclin- 1q32.1 1.18 2.07 1.75 dependent kinase substrate T53907 coatomer protein complex, subunit beta 2 3q23 -2.25 -1.28 1.75 signal transducer (beta prime) AA443948 C-terminal tensin-like 17q21.2 1.15 2.01 1.76 AA457232 transcriptional regulator protein 17q25.3 -2.08 -1.18 1.76 AA608977 Homo sapiens transcribed sequences 1.22 2.14 1.76 R53940 Homo sapiens transcribed sequences 1.24 2.19 1.77 T68464 hypothetical protein FLJ30596 5p13.2 -2.67 -1.50 1.78 R33030 EST 1.45 2.60 1.79 T98663 proteasome (prosome, macropain) subunit, 1p34.2 -2.40 -1.34 1.79 enzyme beta type, 2 AA521490 limkain b1 16p13.13 1.46 2.63 1.80 AA598637 chaperonin containing TCP1, subunit 4 2p15 1.13 2.05 1.81 chaperone (delta) H77772 Homo sapiens transcribed sequence with weak 1.17 2.13 1.83 similarity to protein ref:NP_060219 R34957 EST 1.14 2.10 1.84 AA521469 GTP binding protein 1 22q13.1 1.28 2.36 1.84 N70122 ATPase, H+ transporting, lysosomal V0 12q24.31 -2.59 -1.41 1.84 subunit a isoform 2 R76394 protease, serine, 23 11q14.1 -3.42 -1.85 1.85 enzyme AA261796 multiple endocrine neoplasia I 11q13 1.41 2.62 1.85 ligand binding or carrier N51632 peptidase (mitochondrial processing) alpha 9q34.3 -2.81 -1.52 1.86 enzyme H11270 mannosidase alpha class 2B member 2 4p16.2 -2.01 -1.07 1.87 enzyme T87324 EST 1.15 2.19 1.90 T64905 paired-like homeodomain transcription 4q25-q27 1.06 2.01 1.90 nucleic acid binding factor 2 AA083032 cyclin G1 5q32-q34 1.16 2.21 1.91 AA504327 EST 1.25 2.39 1.92 T49530 lipase, endothelial 18q21.1 1.06 2.07 1.95 enzyme AA486919 ribosomal protein L28 19q13.4 1.07 2.08 1.95 nucleic acid binding H29555 Homo sapiens clone 25248 mRNA sequence 1.16 2.27 1.96 R33353 EST 1.06 2.09 1.96 H99213 Homo sapiens transcribed sequences 1.35 2.65 1.97 AA610071 Homo sapiens transcribed sequences -2.48 -1.25 1.98 AA456400 adenylosuccinate lyase 22q13.1 1.08 2.16 2.00 enzyme W31540 KIAA1450 protein 4q32.1 -3.24 -1.62 2.00 AA461424 ephrin-B2 13q33 -1.12 1.79 2.00 signal transducer AA451903 RNA binding motif protein 9 22q13.1 -1.48 1.36 2.01 nucleic acid binding T71879 complement component 2 6p21.3 -1.18 1.71 2.01 defense/immunity protein T47813 macrophage stimulating 1 (hepatocyte 3p21 -1.06 1.91 2.01 defense/immunity growth factor-like) protein H61608 gene trap ankyrin repeat 4q21.1- -1.42 1.42 2.01 q21.21 R99627 chromosome 6 open reading frame 203 6q21 1.01 2.04 2.02 AA496121 Homo sapiens transcribed sequences -1.28 1.57 2.02 R13558 activated leukocyte cell adhesion molecule 3q13.1 -1.17 1.72 2.02 cell adhesion H21071 baculoviral IAP repeat-containing 1 5q13.1 -1.79 1.13 2.02 apoptosis inhibitor H09245 KIBRA protein 5q35.1 -1.76 1.15 2.02 R99918 Homo sapiens transcribed sequences 1.50 3.03 2.03 AA629904 ADP-ribosylation factor related protein 1 20q13.3 1.22 2.49 2.04 enzyme H94554 EST -1.21 1.68 2.04 N29376 myeloid cell nuclear differentiation antigen 1q22 -1.24 1.65 2.05 nucleic acid binding R26960 peripheral myelin protein 22 17p12- 1.28 2.62 2.05 p11.2 W04996 periphilin 1 12q12 1.12 2.29 2.05 AA026631 Ran GTPase activating protein 1 22q13 -1.33 1.55 2.05 enzyme activator AA496541 KIAA0317 gene product 14q24.2 -1.25 1.64 2.05 enzyme R70084 EST 1.13 2.33 2.05 R10541 hypothetical protein FLJ11526 5q33.2 -1.05 1.96 2.05 AA465017 DnaJ (Hsp40) homolog, subfamily B, 2q32-q34 -1.19 1.73 2.06 chaperone member 2 AA454207 abhydrolase domain containing 2 15q26.1 -1.23 1.67 2.06 enzyme N47797 Homo sapiens, clone IMAGE:5223057, mRNA -1.18 1.76 2.07 T41207 EST -2.74 -1.33 2.07 AA186804 ERO1-like (S. cerevisiae) 14q22.1 -1.25 1.67 2.08 T83861 EST -2.26 -1.08 2.08 AA446231 Homo sapiens transcribed sequences -1.68 1.24 2.08 N21032 EST -1.41 1.48 2.08 AA465366 leukotriene A4 hydrolase 12q22 -2.03 1.03 2.09 enzyme AA459318 tumor protein D52 8q21 -1.08 1.94 2.09 R73539 formin 2 1q43 -1.71 1.22 2.09 N91302 myeloid/lymphoid or mixed-lineage 7q34-q36 -1.21 1.74 2.10 leukemia3 R33335 EST 1.09 2.29 2.10 T91080 EST 2.19 4.62 2.11 H82706 inhibitor of DNA binding 2, dominant 2p25 -1.56 1.36 2.11 negative helix-loop-helix protein N76587 CDC42 binding protein kinase beta (DMPK- 14q32.3 -1.84 1.15 2.12 enzyme like) N95358 myosin IB 2q12-q34 -1.64 1.29 2.13 H28984 phosphatidylserine synthase 1 8q22 -1.72 1.24 2.13 N95657 cyclin fold protein 1 10p11.22 -1.56 1.38 2.15 AA456931 cytochrome c oxidase subunit VIc 8q22-q23 -1.49 1.45 2.15 enzyme N26823 retinoblastoma binding protein 6 16p12.2 -1.34 1.61 2.16 ligand binding or carrier N53616 melanoma ubiquitous mutated protein 19p13.3 -1.07 2.02 2.16 H48793 Homo sapiens transcribed sequences -1.30 1.66 2.16 AA054287 RNA binding motif protein 3 Xp11.2 -1.42 1.52 2.16 nucleic acid binding W94419 UDP-N-acetyl-alpha-D- 5q33.2 -1.71 1.27 2.16 galactosamine:polypeptide N- acetylgalactosaminyltransferase T62865 aldo-keto reductase family 7, member A2 1p35.1- -1.36 1.59 2.16 enzyme (aflatoxin aldehyde reductase) p36.23 AA427595 SHB (Src homology 2 domain containing) 9p12-p11 -1.62 1.33 2.17 signal transducer adaptor protein B AA454005 hypothetical LOC151256 2q33.2 -1.10 1.97 2.17 R08790 Homo sapiens transcribed sequences -1.28 1.69 2.17 R44822 phosphoribosyl pyrophosphate synthetase- 17q24- -1.33 1.63 2.17 enzyme associated protein 1 q25 AA033564 DiGeorge syndrome critical region gene 6-like -1.45 1.50 2.17 AA609783 Homo sapiens mRNA; cDNA DKFZp586A0618 (from -1.30 1.68 2.18 clone DKFZp586A0618) AA464962 hypertension-related calcium-regulated 8q24-qter 1.37 3.01 2.19 gene AA431201 hypothetical protein FLJ33915 12q24.33 -1.23 1.79 2.20 H56424 EST 1.09 2.39 2.20 AA011281 Homo sapiens transcribed sequences -1.83 1.21 2.20 AA620477 serine hydroxymethyltransferase 2 12q12- -1.32 1.68 2.21 (mitochondrial) q14 T69732 Homo sapiens transcribed sequences 1.01 2.22 2.21 R63342 EST -1.41 1.57 2.21 AA172096 endoplasmic reticulum thioredoxin 1p32.3 -1.66 1.33 2.22 ligand binding or superfamily member, 18 kDa carrier W94106 casein kinase 1, epsilon 22q13.1 1.11 2.48 2.24 enzyme AA598483 Tax1 (human T-cell leukemia virus type I) 7p15 -1.24 1.80 2.24 apoptosis inhibitor binding protein 1 H79047 insulin-like growth factor binding protein 2, 2q33-q34 -1.46 1.53 2.24 ligand binding or 36kDa carrier AA521422 THAP domain containing 11 16q22.1 -1.22 1.84 2.24 nucleic acid binding AA402855 polymerase (DNA directed), beta 8p11.2 -1.40 1.60 2.24 enzyme AA457330 calpain 6 Xq23 -1.13 1.98 2.24 enzyme H83178 ubiquitin specific protease 49 6p21.1 -1.38 1.63 2.24 N75745 interleukin 2 receptor, gamma (severe Xq13.1 -1.14 1.97 2.24 signal transducer combined immunodeficiency) AA002007 Homo sapiens mRNA; cDNA DKFZp564D193 (from -2.39 -1.06 2.25 clone DKFZp564D193) H46487 mannosyl (beta-1,4-)-glycoprotein beta- 22q13.1 -1.70 1.33 2.25 enzyme 1,4-N-acetylglucosaminyltransferase H81199 hypothetical protein MGC2198 5q35.3 -1.05 2.14 2.25 H48099 KIAA1972 protein 16q13 -1.42 1.60 2.27 T67106 G protein-coupled receptor 86 3q24 -1.14 1.99 2.27 AA455481 centromere protein B, 80kDa 20p13 -1.50 1.51 2.27 nucleic acid binding H56345 EST -2.23 1.02 2.28 R05336 EST -1.45 1.58 2.29 AA429856 Homo sapiens transcribed sequences -1.40 1.64 2.29 N35341 similar to RIKEN cDNA 1810055D05 3q27.2 -1.74 1.32 2.29 AA143436 ras homolog gene family, member D 11q14.3 -1.18 1.94 2.30 enzyme R10185 protein kinase, lysine deficient 1 12p13.3 -1.71 1.35 2.30 AA007364 EST -1.74 1.33 2.31 R99167 Homo sapiens transcribed sequences -1.56 1.50 2.33 R68492 Homo sapiens LOC145188 (LOC145188), mRNA -1.38 1.70 2.33 W84714 Homo sapiens transcribed sequences -1.08 2.16 2.34 W55997 F-box and leucine-rich repeat protein 11 11q13.1 -1.26 1.86 2.34 ligand binding or carrier AA411876 ubiquitin-conjugating enzyme E2H (UBC8 7q32 -1.14 2.05 2.34 enzyme homolog, yeast) N57872 alanine-glyoxylate aminotransferase 2q36-q37 -1.18 2.00 2.36 enzyme (oxalosis I; hyperoxaluria I; glycolicacidur T73468 EST 1.38 3.30 2.39 H11792 splicing factor, arginine/serine-rich 10 3q26.2- -1.60 1.50 2.39 Nucleic acid binding (transformer 2 homolog, Drosophila) q27 R11335 hypothetical protein KIAA1991 11q13.3 -1.35 1.78 2.41 W21482 chromosome 1 open reading frame 38 1p35.3 -1.10 2.19 2.42 H90225 hypothetical protein MGC8974 1p33- -1.81 1.34 2.42 p32.1 H60491 EST -1.38 1.75 2.42 AA262988 brain-derived neurotrophic factor 11p13 -1.43 1.70 2.42 signal transducer AA443688 GTP cyclohydrolase 1 (dopa-responsive 14q22.1- -1.77 1.37 2.42 enzyme dystonia) q22.2 AA192527 fucosyltransferase 8 (alpha (1,6) 14q24.3 -1.09 2.24 2.44 fucosyltransferase) H15504 annexin A7 10q21.1- -1.25 1.96 2.44 anticoagulant q21.2 AA427667 T cell receptor alpha locus 14q11.2 -1.08 2.26 2.45 signal transducer AA480995 methylene tetrahydrofolate dehydrogenase 2p13.1 -1.50 1.64 2.45 enzyme (NAD+ dependent), methenyltetrahydrofol H50747 Homo sapiens transcribed sequence with weak -1.24 1.99 2.47 similarity to protein pir:JC5238 (H R00418 EST -1.27 1.95 2.47 T88698 protein phosphatase 2, regulatory subunit B 14q32 1.02 2.53 2.48 (B56), gamma isoform W03686 Homo sapiens transcribed sequence with moderate -1.21 2.07 2.49 similarity to protein ref:NP_060 N53169 apolipoprotein C-III 11q23.1- 1.09 2.71 2.49 transporter q23.2 AA598840 polyhomeotic-like 2 (Drosophila) 1p34.3 -1.13 2.25 2.53 AA406081 eukaryotic translation initiation factor 4A, 3q28 -1.34 1.90 2.54 Enzyme isoform 2 H16454 small nuclear ribonucleoprotein D1 18q11.2 -1.50 1.70 2.55 Nucleic acid binding polypeptide 16kDa N66433 KIAA1223 protein 4q28.1 -1.66 1.55 2.56 N48197 Homo sapiens transcribed sequences -1.75 1.47 2.57 AA448468 EST -2.05 1.27 2.59 AA427688 protein phosphatase 2 (formerly 2A), 19q13.41 -2.19 1.20 2.62 Enzyme regulatory subunit A (PR 65), alpha isoform M17886 ribosomal protein, large, P1 15q22 -1.29 2.04 2.63 nucleic acid binding AA398218 Non-metastatic cells 3, protein expressed in 16q13 -1.31 2.01 2.63 Enzyme N55067 RAD23 homolog B (S. cerevisiae) 9q31.2 1.08 2.88 2.65 nucleic acid binding W85927 EST -2.82 -1.06 2.66 W69379 hypothetical protein FLJ25059 11p14.1 -1.41 1.92 2.70 Enzyme AA187982 KARP-1-binding protein 1q44 -1.06 2.57 2.71 AA425755 deleted in lymphocytic leukemia, 1 13q14.3 -1.94 1.42 2.74 R78725 EST -1.21 2.36 2.86 AA047340 hypothetical protein from EUROIMAGE 15q22.33 -1.45 1.99 2.88 1977056 W02483 Homo sapiens transcribed sequence with moderate -1.02 2.84 2.89 similarity to protein ref:NP_057 H95077 Homo sapiens transcribed sequences 1.00 2.88 2.89 H89664 amyloid beta (A4) precursor-like protein 2 11q23- -1.48 1.97 2.91 q25 AA464121 myosin, light polypeptide 5, regulatory 4p16.3 -1.87 1.57 2.95 ligand binding or carrier R66006 acyl-Coenzyme A dehydrogenase, long 2q34-q35 -1.10 2.70 2.98 chain H91631 hypothetical protein MGC15416 16p13.3 -2.11 1.47 3.10 AA460156 EST -1.88 1.67 3.14 H51765 paternally expressed 10 7q21 -1.36 2.35 3.19 nucleic acid binding H22856 EST -2.12 1.51 3.21 AA450037 KIAA0033 protein 11p15.3 1.05 3.50 3.32 Transporter AA521243 mitochondrial ribosomal protein L19 2q11.1- -3.28 1.19 3.90 structural protein q11.2 H53949 EST -1.09 3.61 3.92 W70234 dipeptidylpeptidase 4 (CD26, adenosine 2q24.3 -1.55 2.57 4.00 Enzyme deaminase complexing protein 2) T63031 nuclear receptor co-repressor 2 12q24 -1.19 3.46 4.10 N52315 chromosome 13 open reading frame 10 13q22.2 -1.20 3.74 4.47 T48312 endosulfine alpha 1q21.3 -2.08 2.33 4.85 signal transducer AA464979 hypothetical protein FLJ21820 2p24.2 -1.82 3.67 6.70 Enzyme AA454153 hypothetical protein LOC149837 20p13 -8.24 1.89 15.54

T2D: type 2 diabetes mellitus without nephropathy T2DN: type 2 diabetes mellitus with nephropathy C: controls without diabetes and nephropathy

Values indicate differential expression at p<0.05. Significant regulation indicated a 2-fold change between groups using a common error model and a modified z test. All 2-fold changes were statistically significant at p<0.05 after FDR correction for multiple comparisons.