Section of Thoracic Surgery, University of Manitoba

G O R D O N B U D U H A N BSc MD MSc FRCSC

Assistant Professor of Surgery Section of Thoracic Surgery, University of Manitoba Room GE 611 Health Sciences Centre 820 Sherbrook Street Winnipeg Manitoba Canada R3A 1R9 Phone: 204-787-3109 Fax: 204-787-7143 [email protected]

EDUCATION______

2006-2009 Fellowship – General Thoracic Surgery University of British Columbia, Vancouver Canada Fellow, Royal College Surgeons of Canada, Thoracic Surgery

2007-2008 Fellowship – Minimally Invasive Thoracic and Foregut Surgery Swedish Medical Center, Seattle, Washington, USA

2000-2006 Residency – General Surgery University of Manitoba, Winnipeg, Canada Fellow, Royal College Surgeons of Canada, General Surgery

2003-2005 Masters of Science - Surgery University of Manitoba Winnipeg, Canada

1996-2000 Doctor of Medicine (with honors) University of Toronto Toronto, Canada

1992-1996 Bachelor of Science, General (with distinction) University of Manitoba Faculty of Science Winnipeg, Canada

ACADEMIC & CURRENT STAFF HOSPITAL APPOINTMENTS______

Nov 2013 – current Program Director, Thoracic Surgery Fellowship Program, University of Manitoba, Winnipeg, Canada Aug 2013 – current Assistant Professor of Surgery, Staff Attending Thoracic Surgeon Health Sciences Centre, Winnipeg, Canada Jan 2012 – July 2013 Thoracic Surgery Fellowship Director, Division of Thoracic Surgery, QEII Health Sciences Center, Dalhousie University, Halifax Canada Oct 2009 – July 2013 Assistant Professor of Surgery, Staff Attending Thoracic Surgeon QEII Health Sciences Center, Dalhousie University, Halifax, Canada

1 LICENSES & CERTIFICATION______2013 Full License, College of Physicians & Surgeons Manitoba, Thoracic Surgery 2009 Full license, College of Physicians & Surgeons Nova Scotia, Thoracic Surgery 2007 Certification, American Board of Surgery 2007 Physician License, Medicine & Surgery, State of Washington 2001 License, Medical Council of Canada 1997-2001 USMLE Steps 1, 2, 3

ACADEMIC HONORS & AWARDS______

2004 University of Manitoba Medical Students Association Teaching Award nominee

2004 2nd place, Outstanding Research Project, University of Manitoba General Surgery Resident Research Day

2003-2004 University of Manitoba Surgical Postgraduate Scholarship

2003 3rd place, Outstanding Research Project, University of Manitoba General Surgery Resident Research Day

2002 Health Sciences Center Medical Staff Council Research Fellowship Award

2000 Dr. Evelyn Bateman Award Highest academic achievement in Anesthesia, clinical clerkship - University of Toronto

1999 George Brown Memorial Award Outstanding clinical research, Undergraduate Medicine, University of Toronto

1998 Cara Phelan Trauma Research Summer Scholarship

1997-1998 Honors standing –Undergraduate Medicine, University of Toronto

1992-1996 Dean’s List – Faculty of Science, University of Manitoba Institute of Chartered Accountants’ Academic Scholarship University of Santo Tomas Academic Scholarship St. Paul’s High School Board of Directors’ Silver Medal

PUBLICATIONS______

Peer reviewed papers:

2012 A. Qureshi, R. Aye, G. Buduhan, A. W. Knight, J. Orlina, A. Farivar, O. J.Wagner, S. McHugh, B. Louie. The Laparoscopic Nissen-Hill Hybrid: Pilot Study of a Combined Anti-Reflux Procedure Surg Endosc. 2013 Jan 10. [Epub ahead of print]

2012 R. Urquhart, C. Kendell, J. Sargeant, G. Buduhan, P. Johnson, D. Rayson, E. Grunfeld, G.A. Porter. How do surgeons decide to refer patients for adjuvant 2 cancer treatment? Protocol for a qualitative study Implement Sci. 2012 Oct 25;7:102.

2012 R.Aye, L. Swanstrom, S. Kapur, G. Buduhan, C. Dunst, A. Knight, J. Malmgren, B. Louie. A randomized multi-institution comparison of the laparoscopic nissen and hill repairs. Annals of Thoracic Surgery 2012; 94(3):951-8

2010 G. Buduhan, J. Orlina, B. Louie, E. Vallières, R. Aye. Endoscopic and Manometric Position-Related Characteristics of the Normal Gastroesophageal Junction. Surgical Endoscopy 2010: Sept; 24(9): 2165-9

2009 G. Buduhan, S. Menon, R. Aye, B. Louie, V. Mehta, E. Vallières. Trimodality Therapy for Malignant Pleural Mesothelioma. Annals of Thoracic Surgery 2009: Sept; 88(3):870-6

2009 B. Hunt, B. Louie, R. Aye, G. Buduhan, E. Vallieres. Sarcoidosis As A Benign Cause Of Lymphadenopathy In Cancer Patients. American Journal of Surgery 2009: May; 197(5):629-32

2006 G. Buduhan, L. Tan, K. Kasian, S. Mink. Volume Reduction Surgery Impairs Immediate Postoperative Pulmonary Function in Canine Emphysema. American. Journal of.Respiratory and Critical Care Medicine 2006: Dec; 174(12): 1310-18

2000 G. Buduhan, D. I. McRitchie. Missed Injuries in Patients with Multiple Trauma. Journal of Trauma: 2000: Oct; 49(4):600-5

Books & Chapters:

2009 G. Buduhan, R. J. Finley. Thoracoscopic Surgery of the Mediastinum and Esophagus in: L. Swanstom, N. Soper, (Eds.) Mastery of Endoscopic and Laparoscopic Surgery, 3rd Edition © 2009 Lippincott Williams & Williams

2005 G. Buduhan. Thesis – Effect of Lung Volume Reduction Surgery on Lung Mechanics and Maximal Flow in a Canine Model of Upper Lobe Emphysema. Master of Science, University of Manitoba, Faculty of Medicine.

2000 G. Buduhan, S. Minor. (eds.), General Surgery. In Law M, Rotenberg R (eds.): 2000 Medical Council of Canada Qualifying Examination Review Notes & Lecture Series. Toronto: University of Toronto Faculty of Medicine, 2000.

Abstracts:

2013 D. French, D. Bethune, H. Henteleff, M. Johnston, G. Buduhan. Cost Analysis of VATS vs. Open Lobectomy for NSCLC: Results of a Single Institution Study. 3 Abstract ID 1440 15th Annual World Conference on Lung Cancer October 2013, Sydney, Australia

2013 S. Rajaraman, A.Ross, G.Sun, L. Mulroy , H. Hollenhorst, M. Abdolell, G. Buduhan, M. Rajaraman. The Effectiveness of Halifax-Produced 18 FDG- PET/CT in the Evaluation of Patients with Solitary Pulmonary Nodule or Suspected Lung Cancer and the Impact on Patient Management. Dalhousie University Medical & Radiation Oncology Resident Research Day April 2013 Halifax Nova Scotia

2012 G. Buduhan. Practice patterns in the treatment of locally advanced resectable esophageal carcinoma: A national survey of Canadian thoracic surgeons. Abstract ID: e14695 2012 ASCO Annual Meeting Proceedings I Chicago Illinois USA

2012 L. Donahoe, G. Buduhan.. Thoracic Surgery Experience in Canadian General Surgery Residency Programs Association for Surgical Education Annual Meeting. San Diego, California USA

2012 R. Aye, L. L. Swanstrom, S. Kapur, G. Buduhan, C. M. Dunst, A. Knight, J. A. Malmgren, B. E. Louie. A Prospective Randomized Multicenter Trial Comparing the Laparoscopic Nissen Fundoplication and the Laparoscopic Hill Repair for Uncomplicated Gastroesophageal Reflux Disease Society of Tho- racic Surgeons 48th Annual Meeting. Fort Lauderdale, Florida USA

2011 K. Walker, J. Gruchy, Z. Xu, G. Buduhan Comparative Analysis of Toxicity and Pathologic Response Rates Following Neoadjuvant Chemotherapy and Chemoradiation for Locally Advanced Esophageal Carcinoma 2011 IHRTP Interprofessional Health Research Day, Halifax, Nova Scotia

2011 K. Walker, D. Bethune, H. Henteleff, M. Johnston, G. Buduhan Neoadjuvant Therapy for Esophageal Carcinoma is not Associated with Increased Perioperative Morbidity or Mortality 2011 BHCRI 3rd Annual Cancer Research Conference, Atlantic Canada, Halifax, Nova Scotia

2011 C. Knickle, D. Bethune, H. Henteleff, M. Johnston, G. Buduhan Sublobar Resection Compared To Lobectomy For Early Stage Non-Small Cell Lung Cancer: A Single Institution Study 2011 BHCRI 3rd Annual Cancer Research Conference, Atlantic Canada Halifax, Nova Scotia

2011 D. Manos, Z. Xu, G. Buduhan, M. Johnston Low Dose Screening CT of the Chest: Local Results of the Pan-Canadian Early Detection of Lung Cancer Study 2011 BHCRI 3rd Annual Cancer Research Conference, Atlantic Canada Halifax, Nova Scotia

2011 A. Stueck,, Z. Xu , G Buduhan DIPNECH, tumorlets, and a typical carcinoid: A spectrum of neoplasia in a 48 year old female and review of the literature. 2011 Canadian Association of Pathologists Annual Meeting, Vancouver BC

2009 G. Buduhan, B. Louie, E. Vallieres, R. Aye. Endoscopic & Manometric Characteristics of the Gastroesophageal Valve in Lateral Decubitus & Upright 4 Positions in Clinically Normal Patients SAGES 2009, Phoenix, Arizona

2009 G. Buduhan, S. Menon, R. Aye, B. Louie, V. Mehta, E. Vallières. Induction Chemotherapy, Extrapleural Pneumonectomy and Hemithoracic Radiation Therapy for Malignant Pleural Mesothelioma. Society of Thoracic Surgeons, San Francisco, USA, Jan. 2009

2008 G. Buduhan, B. Louie, E. Vallieres, J. Orlina, R. Aye. The Right Lateral Decubitus Position Is Associated With A Weakened Lower Eosphageal Sphincter - Position Related Physiology Of The Normal Gastroesophageal Junction. International Society for Diseases of the Esophagus, Budapest, Hungary, Sept. 2008

2008 G. Buduhan, B. Louie, J. Orlina, S. Daneil, E. Vallieres, J. Rees, R. Aye. The Nissen Hill “Hybrid” – Pilot Study Of A New Antireflux Repair. International Society for Diseases of the Esophagus, Budapest, Hungary, Sept. 2008

2008 V. K. Mehta, E. Vallieres, J. Ye, K. McCune, G. Buduhan, R. Aye, B. Louie, M. Abboud-Finch, T. Wong. Early Results Of Adjuvant IGRT-IMRT Following Extrapleural Pneumonectomy For Malignant Pleural Mesothelioma. ASTRO-ASCO Multidisciplinary Symposium in Thoracic Oncology, Nov. 2008

2008 B. Hunt, B. Louie, R. Aye, G. Buduhan, E. Vallieres. Sarcoidosis As A Benign Cause Of Lymphadenopathy In Cancer Patients. North Pacific Surgical Association 95th Annual Meeting, Seattle Washington, Nov. 2008

2003 G. Buduhan, A. Abdoh, R. Saadia. Predictors of Wound Infection Following Appendectomy. Canadian Journal of Surgery Vol. 46(suppl.):12, August 2003

Book Reviews:

2000 G. Buduhan Book Review: Trauma: A Scientific Basis for Care. University Toronto Medical Journal 77(3): 295-296 May 2000

INVITED PRESENTATIONS______

Neoadjuvant Chemotherapy vs. Neoadjuvant Chemoradiation for Patients with Resectable Esophageal Cancer: A Pilot Randomized Study 2013 Thoracic Disease Site Group Retreat, Cancer Care Manitoba, Winnipeg, Canada

Surgical Trials and Tribulations: the Quest to Conquer GERD 2013 Dept of Surgery Grand Rounds, University of Manitoba, Winnipeg Manitoba

There is no “I” in “Cancer Team”: Conducting Multimodality Oncology Trials 2012 Beatrice Hunter Cancer Research Institute Seminar Series Session, Halifax Neoadjuvant Chemotherapy vs. Neoadjuvant Chemoradiation for Patients with Resectable Esophageal Cancer: A Pilot Randomized Study 2012 GI Disease Site Grp: NCIC-Clinical Trials Group Annual Spring Meeting, Toronto 5 Review of Surgical Procedures in Thoracic Surgery 2012 Nursing Education Week, QEII Health Sciences Center, Halifax

Neoadjuvant Therapy for Esophageal Carcinoma 2012 Oncology Grand Rounds, Halifax

Controversies in Neoadjuvant Therapy for Locally Advanced Esophageal / Gastroesophageal Junction Carcinoma 2011 3rd Annual Atlantic Thoracic Oncology Conference, Halifax

Minimally Invasive surgery for Non-Small Cell Lung Cancer 2010 2nd Annual Atlantic Thoracic Oncology Conference, Halifax

Minimally Invasive Thoracic Surgery 2010 Nursing Education Week, Victoria Hospital, Halifax

Esophageal Disorders and GERD 2010 Otolaryngology Residents Education Rounds, Dalhousie University, Halifax

Advances in Thoracic Surgery 2010 Educational Rounds, Division of Respirology, Dalhousie University, Halifax

Advances in Thoracic Surgery 2009 Grand Rounds, Dept of Surgery, Dalhousie University, Halifax

Endoscopic & Manometric Position-Related Characteristics of the Normal Gastroesophageal Junction. 2009 Oral Presentation. Society of American and Gastrointestinal Surgeons Meeting Phoenix, Arizona, USA

Trimodality Therapy for Malignant Pleural Mesothelioma. 2009 Oral presentation. Society of Thoracic Surgeons 45th Annual Meeting, San Francisco, USA

Acute Changes in Parameters of Maximal Expiratory Flow Following Lung Volume Reduction Surgery in a Canine Model of Upper Lobe Emphysema 2004 Oral presentation. University of Manitoba General Surgery Residents’ Research Day – Winnipeg Manitoba

Barrett’s Esophagus - Current Controversies: 2002 University of Manitoba Dept of Surgery Grand Rounds Winnipeg, Manitoba

Missed injuries in multiple trauma patients: 1999 Oral presentation. 68th Annual Meeting: Royal College of Physicians & Surgeons of Canada - paper session, Trauma Association of Canada, Montreal, Quebec. Oral presentation. University of Toronto Trauma Research Day – University of Toronto Trauma Committee & the Cara Phelan Centre for Trauma Research. Toronto, Ontario Poster presentation. University of Toronto Medical Student Research Day – Toronto, Ontario 6 RESEARCH ACTIVITIES______

Cost Analysis of VATS vs. Open Lobectomy for NSCLC: Results of a Single Institution Study 2012-present -Principal Investigator (Dr. Danny French, surgery resident associate investigator) -retrospective cohort analysis of intraoperative, postoperative and global hospital costs between patients undergoing VATS or open lobectomy for early stage NSCLC at the QEII Health Sci- ences Center Halifax NS

Neoadjuvant Chemotherapy vs. Neoadjuvant Chemoradiation for Patients with Resectable Esophageal Cancer: A Pilot Randomized Study 2011-present -Sponsor / Principal Investigator: Phase III feasibility randomized trial of neoadjuvant chemotherapy vs. chemoradiation followed by esophagectomy for patients with locally advanced resectable esophageal carcinoma

How do surgeons decide to refer patients for adjuvant cancer treatment? A qualitative study 2012 - present Co-Investigator: qualitiative study using semi-structured interviews of surgical oncologists (breast, colorectal, thoracic) to 1) identify patient, surgeon, institutional, and health system factors that influence surgeons’ decisions to refer non-small cell lung, breast, and colorectal cancer patients to oncology services when consideration for (neo)adjuvant therapy is recommended; and 2) identify potential strategies that could optimize referral to oncology for appropriate individuals

Practice Patterns in the Treatment of Resectable Esophageal Carcinoma: A National Survey of Canadian Thoracic Surgeons 2011-present -Principal Investigator: Survey of practicing thoracic surgeons to summarize individual practice patterns and opinions in the treatment of esophageal cancer

CALGB 140503 Randomized Trial of Lobectomy vs. Sublobar Resection in Small, Peripheral NSCLC 2011–present -Halifax Site Principal Investigator

Adjuvant Melatonin for Prevention of Lung Cancer Recurrence and Mortality (AMPLCaRe) 2011 – present -Halifax Site Principal Investigator: Randomized placebo-controlled trial of melatonin supplementation as adjuvant treatment of lung cancer for prevention of recurrence

Early Detection of Lung Cancer - A Pan-Canadian Study 2010 – present -Halifax Site co-investigator -National lung cancer screening study using serum biomarkers, high resolution CT, autofluorescence bronchoscopy

Thoracic Surgery Experience in Canadian General Surgery Residency Programs 2010 - present -Principal Investigator (Dr. Laura Donahoe, surgery resident associate investigator) -National survey study of surgical resident experience during thoracic surgery rotations

7 Results of Neoadjuvant Therapy for Esophageal Carcinoma: A Single Institution Review 2011-present -Principal Investigator (Kirsten Walker, medical student associate investigator) -retrospective cohort study to determine the clinical outcomes following neoadjuvant chemotherapy and chemoradiation and esophagectomy for esophageal carcinoma in Nova Scotia

Outcomes of Sublobar Resection in Non-Small Cell Lung Cancer 2010 – present -Principal Investigator (Corey Knickle, medical student associate investigator) -retrospective review of outcomes, survival and recurrence patterns following sublobar resection for NSCLC University of Manitoba Master of Science in Surgery Thesis Project 2003 – 2005 Acute Changes in Parameters of Maximal Expiratory Flow Following Lung Volume Reduction Surgery in a Canine Model of Upper Lobe Emphysema Supervisors: Dr. S. Mink, Dr. A. L. Tan Divisions of Respirology & Thoracic Surgery, Health Sciences Center, University of Manitoba

GRANTS AND RESEARCH AWARDS

2013-2016 University of Manitoba Research Grant $50,000 (Principal Investigator) Neoadjuvant Chemotherapy vs. Neoadjuvant Chemoradiation for Patients with Resectable Esophageal Cancer: A Pilot Randomized Study

2012-2013 Capital Health Research Fund $2,587 - Daniel French General Surgery Resident (G. Buduhan supervisor) Cost Analysis of VATS vs. Open Lobectomy for NSCLC: Results of a Single Institution Study

2012-2013 Nova Scotia Health Research Foundation Establishment Grant $73,694 over 2 years (Principal Investigator) Neoadjuvant Chemotherapy vs. Neoadjuvant Chemoradiation for Patients with Resectable Esophageal Cancer: A Pilot Randomized Study

2012-2013 CIHR Operating Grant –$82,348 over 2 years (Co-Investigator - G. Porter Principal Investigator) How do surgeons decide to refer patients for adjuvant cancer treatment? A qualitative study

2012 Dalhousie University Department of Surgery Seed Grant Award $50,000 (Principal Investigator) Neoadjuvant Chemotherapy vs. Neoadjuvant Chemoradiation for Patients with Resectable Esophageal Cancer: A Pilot Randomized Study

2011 First Place, Poster Presentation, Beatrice Hunter Cancer Research Institute 3rd Annual Cancer Research Conference, Atlantic Canada – Kirsten Walker (G. Buduhan: supervisor)

2011-2012 Capital Health Research Fund $15,000 (Principal Investigator) Neoadjuvant Chemotherapy vs. Neoadjuvant Chemoradiation for Patients with Resectable Esophageal Cancer: A Pilot Randomized Study

2011 Nora Stephen Oncology Scholarship $6,500 – Corey Knickle, Dalhousie Medical Student (G. Buduhan Supervisor) Outcomes of Sublobar Resection in Non-Small Cell Lung Cancer

8 2011 Nora Stephen Oncology Scholarship $6,500 – Kirsten Walker, Dalhousie Medical Student (G. Buduhan Supervisor) Results of Neoadjuvant Therapy for Esophageal Carcinoma: A Single Insitution Review

THORACIC CLINICAL PROGRAM DEVELOPMENT_(2009 – present)______

CT Microcoil-Guided Thoracoscopic Lung Resection – developed and initiated program, trained surgeons at QEII-Health Sciences Center, Halifax, Nova Scotia

Thoracoscopic Lobectomy - developed and initiated program, performed first VATS lobectomy in Nova Scotia, trained surgeons at QEII-Health Sciences Center, Halifax, Nova Scotia

Neoadjuvant Chemoradiation for Esophageal Carcinoma – initiated multidisciplinary induction treatment program of combined preoperative chemotherapy plus radiation followed by esophagectomy for resectable tumors of the esophagus at Cancer Care Nova Scotia

EDUCATIONAL ACTIVITIES______

Dalhousie University, Halifax: 2013 Lecturer: 2nd Year Medical Students “Lung Cancer” Dalhousie Medical School 2012 – present: Fellowship Director: Thoracic Surgery, Dalhousie University / QEII HSC 2012 – present: Presenter: Dalhousie General Surgery Journal Club 2011 – 2012 Tutor: Med II Clinical Skills - Respirology 2010 – present Member: Department of Surgery Undergraduate Education Committee 2010 – 2012 Clerkship Coordinator: Division of Thoracic Surgery 2009 – present Lecturer: Third year Medical Students Surgery Clerkship seminar: Esophageal Diseases 2010 - present Examiner: Third year Medical Students Surgery Clerkship Objective Structured Clinicial Examinations (OSCE) 2010 - present Examiner: General Surgery Residents Mock Oral Examination Prep 2010 - present Lecturer: Thoracic Surgery Nursing Educational Seminars: Perioperative Care of the Thoracic Surgery Patient 2010 Chair, Dalhousie Surgery Research Day Award Committee

Swedish Medical Center, Seattle: 2008 Member, Oral Examination Committee, Swedish Medical Center General Surgery Residency Program 2008 Lecturer: Thoracic Surgery Nursing Educational Seminars: Perioperative Care of the Thoracic Surgery Patient

University of Manitoba, Winnipeg 2001 – 2006: Member, University Manitoba Dept of Surgery Postgraduate Education Committee

University of Toronto, Toronto 1999-2000 Student Representative, Dept of Anaesthesia 1998-1999 Committee Member, Undergraduate Medical Research Day Committee Interviewer / academic assessor, applicants to University of Toronto Faculty of Medicine 9 COMMITTEES AND MEMBERSHIPS

Member: Dalhousie University Plastic Surgery Division Internal Review Committee 2013 Active Investigator, NCIC Clinical Trials Group Thoracic Surgery representative, NCIC Clinical Trials Group Thoracic Disease Site Committee QEII Health Sciences Center, Halifax NS Member, NCIC Clinical Trials Group Esophagogastric Disease Oriented Working Group (EDOG) Judge, Canadian Association of Thoracic Surgeons Scientific Poster Competition, 2011 London Member, Capital Health Research Fund Committee Reviewer, Grant Applications: Physicians’ Services Incorporated Foundation Member, Beatrice Hunter Cancer Research Institute Member, Beatrice Hunter Cancer Research Institute Scientific Review Committee Member, Integrated Health Research Training Partnership Steering & Implementation Committee Member, Dalhousie Surgery Undergraduate Education Committee Member, Canadian Association of Thoracic Surgeons Member, Canadian Association of Thoracic Surgeons Research Committee Member, Canadian Association of General Surgeons

COURSES 2011 - NCIC Clinical Trials Group New Investigator Clinical Trials Course, Kingston ON 2011 – Thoracic Trauma Symposium, Synthes – Toronto ON 2008 – VATS lobectomy course, Ethicon – Cincinnati OH

JOURNALS: Manuscript Reviewer

Surgical Endoscopy – 1 manuscript reviewed July 2011 Saudi Journal of Gastroenterology – 2 manuscripts reviewed from Dec 2009 – Oct 2010