Supplementary Materials s16

Supplementary Materials

The analysis of the market success of FDA approvals by probing top 100 bestselling drugs

Short title: Top 100 bestselling drug analysis

Jaroslaw Polanski*, Jacek Bogocz, Aleksandra Tkocz Institute of Chemistry, University of Silesia, Szkolna 9, 40-006 Katowice, Poland * Corresponding author. Tel.: +48323591128; fax: +482599978, e-mail address: [email protected] Polynomial model for Figure 3a:

Table 1 Covariance table (based on normalized data)

Source Mean Sales Molecular Weight pIC50 Mean Drug Age Mean Sales 0.024 Molecular Weight 0.001 0.021

pIC50 0.000 0.000 0.015 Mean Drug Age 0.002 -0.002 -0.002 0.031

Table 2 Correlation table (Pearson coefficients):

Source Mean Sales Molecular Weight pIC50 Mean Drug Age Mean Sales 1.00 Molecular Weight 0.06 1.00

pIC50 -0.01 0.00 1.00 Mean Drug Age 0.09 -0.07 -0.09 1.00 Figure 1

PCA based on raw dataset of Mean Sales, Molecular Weight, pIC50 and Mean Drug Age

(2003-2013). Mean Drug Age (2003-2013) binned into four following ranges:

<5, 5-10, 10-15, >15

Table 3 Correlation table.

Source Mean Sales Molecular Weight pIC50 Mean Drug Age Mean Sales 1.00 Molecular Weight -0.47 1.00

pIC50 -0.44 -0.59 1.00 Mean Drug Age 0.87 -0.84 0.06 1.00

Figure 2

PCA of Mean Sales, Molecular Weight, pIC50 and Mean Drug Age (2003-2013). Drug Age (2003) binned into four following ranges:

<5, 5-10, 10-15, >15

pIC50 -0.44 -0.59 1.00 Mean Drug Age 0.87 -0.84 0.06 1.00

Figure 3

PCA of Mean Sales, Molecular Weight, pIC50 and Mean Drug Age (2003). Drug Age (2013) binned into four following ranges:

<5, 5-10, 10-15, >15

pIC50 -0.57 -0.36 1.00 Mean Drug Age 0.87 -0.89 0.10 1.00

Figure 4

PCA of Mean Sales, Molecular Weight, pIC50 and Mean Drug Age (2013).