Supplementary Information s43

Supplementary Information

Title.

Quality of dietary intake in relation to body composition in patients with chronic obstructive pulmonary disease eligible for pulmonary rehabilitation

Running title.

Quality of dietary intake in Chronic Obstructive Pulmonary Disease

Authors.

Coby van de Bool, MSc 1

Christel Mattijssen-Verdonschot 2

Paula P.M.J. van Melick 2

Martijn A. Spruit, PhD 2

Frits M.E. Franssen, PhD, MD 2

Prof. Emiel F. M. Wouters, MD 1,2

Prof. Annemie M.W.J. Schols 1

Erica P. A. Rutten, PhD 2

1. NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine,

Maastricht University Medical Centre +, Maastricht, the Netherlands. 2. Program Development Centre,

Centre of Expertise for Chronic Organ Failure (CIRO +), Horn, the Netherlands.

Adress for correspondence.

Coby van de Bool, MSc. NUTRIM School for Nutrition, Toxicology and Metabolism, Department of

Respiratory Medicine, Maastricht University Medical Centre +, PO Box 616, 6200 MD, Maastricht, the

Netherlands. E-mail: [email protected].

1 Supplementary Table 1. Patient characteristics after stratification for low FFMI or abdominal obesity.

Normal FFMI Low FFMI P- Non-abdominal obese Abdominal obese P-

(n = 435) (n = 129) value (n = 97) (n = 337) value Male, % 62.5 36.4 <0.001 51.5 59.3 0.171 Age, years 65.0 (59.0 – 73.0) 63.0 (57.0 – 68.5) 0.008 62.0 (54.5 - 72.0) 65.0 (59.0 - 72.0) 0.026 Length, cm 168.0 (161.0 – 174.5) 164.0 (158.0 – 172.0) 0.003 167.0 (160.0 - 175.5) 168.0 (160.6 - 174.0) 0.450 Weight, kg 72.6 (64.5 – 82.5) 55.2 (49.5 – 64.1) <0.001 56.4 (51.8 - 66.3) 71.9 (63.8 - 82.8) <0.001 2 BMI, kg/m 26.2 (23.3 – 29.2) 20.9 (19.0 – 22.6) <0.001 20.8 (19.2 - 22.3) 25.8 (23.4 - 29.3) <0.001 FFM, kg 51.0 (43.3 – 56.8) 38.7 (34.6 – 45.1) <0.001 45.2 (38.6 - 53.3) 48.9 (41.3 - 56.0) 0.005 2 FFMI, kg/m 17.8 (16.6 – 19.1) 14.6 (13.9 – 15.2) <0.001 16.1 (14.8 - 17.6) 17.5 (15.7 - 19.1) <0.001 Abdominal obese, % 81.8 63.3 37.1 18.4 <0.001 FEV1, % of predicted 49.0 (35.0 – 65.0) 38.0 (26.0 – 56.5) <0.001 43.0 (29.5 – 61.0) 48.0 (33.3 – 65.0) 0.043

FEV1/VC, % 38.0 (31.0 – 48.0) 34.0 (27.0 – 42.5) 0.001 36.0 (26.5 – 43.5) 38.0 (31.0 – 49.0) 0.028

FVC, % of predicted 98.0 (83.0 – 115.0) 90.0 (76.0 – 107.5) <0.001 98.0 (80.0 – 117.5) 98.0 (80.0 – 113.0) 0.903

Results are presented as median (interquartile range) and were compared by the Student’s t test for independent samples. Results of statistical analysis showed that patients with low FFMI differed from patients with normal FFMI in age, length, weight, BMI, FFM,

FFMI and airflow limitation. Abdominal obese patients differed from non-abdominal obese patients in age, weight, BMI, FFM, FFMI and airflow limitation.

Abbreviations:

BMI = body mass index; FFM = fat free mass; FFMI = FFM-index; FEV1 = forced expiratory volume in one second; FVC = forced vital capacity.

2 Supplementary Table 2. Patient characteristics after stratification for low FFMI and abdominal obesity.

I. Normal FFMI II. Normal FFMI III. Low FFMI IV. Low FFMI P- & non-abdominal obese & abdominal obese & non-abdominal obese & abdominal obese value (n =61) (n =275) (n =36) (n = 62) Male, % 65.6 III,IV 63.6 III,IV 27.8 40.3 <0.001 Age, years 65.0 (57.5 - 74.5) III 66.0 (59.0 - 73.0) III 58.0 (51.3 - 63.5) 64.0 (58.0 - 72.0) III 0.001 Length, cm 170.0 (162.0 - 176.5) IV 169.0 (161.0 - 174.0) 161.8 (160.0 - 169.4) 166.0 (158.0 - 172.3) 0.030 Weight, kg 64.1 (53.5 - 69.8) II,III 75.0 (67.4 - 85.4) III,IV 52.7 (47.2 - 55.8) IV 60.5 (52.8 - 65.5) <0.001 BMI, kg/m2 21.5 (19.8 - 23.8) II,III 26.7 (24.6 - 29.9) III,IV 19.4 (18.0 -20.9) IV 21.7 (20.0 - 24.4) <0.001 FFM, kg 50.8 (42.7 - 55.6) III,IV 51.9 (43.9 - 57.3) III,IV 37.2 (34.3 - 44.9) 39.0 (35.2 - 45.4) <0.001 FFMI, kg/m2 17.2 (16.2 - 18.1) II,III,IV 18.1 (16.8 - 19.3) III,IV 14.3 (13.5 - 14.9) 14.6 (13.9 - 15.3) <0.001

III III FEV1, % of predicted 48.0 (34.0 - 66.0) 49.0 (35.0 - 66.0) 35.0 (22.0 - 50.8) 40.5 (27.8 - 61.0) 0.005

III FEV1/VC, % 38.0 (30.5 - 44.5) 38.5 (31.8 - 49.0) 29.0 (25.0 - 41.5) 35.5 (28.0 - 44.5) 0.023 FVC, % of predicted 99.0 (80.0 - 122.5) 98.0 (81.0 - 115.0) 89.5 (81.3 - 112.3) 92.0 (78.8 - 109.3) 0.130 Results are presented as median (interquartile range) and compared by ANOVA. Results of statistical analysis showed that patients with or without low FFMI and with or without abdominal obesity differed in age, length, weight, BMI, FFM, FFMI and airflow limitation.

Abbreviations:

BMI = body mass index; FFM = fat free mass; FFMI = FFM-index; FEV1 = forced expiratory volume in one second; FVC = forced vital capacity.

I, II, III or IV Represents a significant difference at P < 0.05 with respectively strata nr. I,II,III or IV.