Polymyxin B and Bacitracin Ointment

FORMULATION AND EVALUATION OF POLYMYXIN B AND BACITRACIN OINTMENT

M. Pharm Dissertation Protocol Submitted to

Rajiv Gandhi University of Health Sciences, Karnataka Bangalore– 560 041

Mr. S.SHADAB AZHAR B.Pharm

Under the Guidance of

Mr. ANUP KUMAR ROY M.Pharm,(Ph.D) Asst. Professor & HOD

Department of Industrial Pharmacy, Acharya & B.M. Reddy College of Pharmacy, Soldevanahalli, Chikkabanavara (Post) Hesaraghatta, Main Road, Bangalore – 560 090. 2010-2011 RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, KARNATAKA, BANGALORE. ANNEXURE - II PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION Mr. S.SHADAB AZHAR . Name of the Candidate 1. H-NO-HIG-1/2,ABBAS NAGAR, and Address KURNOOL-518002 ANDHRA PRADESH.

ACHARYA & B.M. REDDY COLLEGE OF PHARMACY, 2. Name of the Institution Hesaraghatta Main Road, Soldevanahalli, Chikkabanavara Post. Bangalore-560090

M. Pharm 3. Course of Study and Subject (Industrial pharmacy)

4. Date of Admission 30-May-2010

5. TITLE OF THE PROJECT:

FORMULATION AND EVALUATION OF POLYMYXIN B AND BACITRACIN OINTMENT

6. BRIEF RESUME OF THE INTENDED WORK:

6.1 NEED FOR THE STUDY:

The objective of the work is to formulate and evaluate ointment of combination of the drugs Polymyxin B and Bacitracin which are antibiotics with an aim to improve its bioavailability and better management of diseases . The ointment will be useful to treat wounds (e.g., cuts, scrapes, burns) and to help prevent or treat skin infections. Minor skin infections and wounds usually heal without treatment, but some minor skin wounds may heal faster when an antibiotic is applied to the affected area. This will contain antibiotics that work by slowing or stopping the growth of bacteria. 6.3 Polymyxin B is an antibiotic primarily used for resistant gram-negative infections. It is derived 7.3 from the bacterium Bacillus polymyxa. Polymyxin B sulfate has a bactericidal action against almost all 6.3 gram-negative bacilli except the Proteus group. Polymyxins bind to the cell membrane and alter its structure making it more permeable. The resulting water uptake leads to cell death.