Georgia Institute of Technology Institutional Biosafety Committee Meeting Minutes Thursday, October 30, 2014 11:00am ______

Voting members present:  Robert Finton, Community Member  Mary Beran, Office of Research Integrity Assurance  Deborah Cook, Community Member  Kirill L Lobachev, Biology  Jeff Owens, Community Member

Voting members absent:  Todd McDevitt, Biomedical Engineering  Andres Garcia, Mechanical Engineering

Non-voting attendees:  Katia Peixoto, Office of Research Integrity Assurance  Meagan Fitzpatrick, Environmental Health & Safety

The meeting was called to order at 11:00am when a quorum was achieved.

1. Approval of Meeting Minutes Minutes of September 29, 2014 The motion to approve the registration as written was made, seconded and unanimously approved.

VOTE: In favor – 4 Against – 0 Abstained – 1

2. Registrations/Amendments for Discussion at Today’s Meeting

R14018 PI: Andres Garcia Title: Stem Cell Survival and Engraftment in Bone Repair Category: Non-Exempt; BSL2, ABSL1 Modification: material (cells) and personnel Status: Under Review Reviewers: sent separately as PI is committee member

The Registration was previously approved and is being amended to update registration.

VOTE: In favor – 5 Against – 0 Abstained – 0

R14022 PI: Gang Bao Title: Nanomedicine Center for Nucleoprotein Machines Category: Non-Exempt; BSL2 A Unit of the University System of Georgia. An Equal Education and Employment Opportunity Institution.

Georgia Institute of Technology Institutional Biosafety Committee (IBC) Office of Research Integrity Assurance [email protected] www.ibc.gatech.edu Status: Under Review Reviewers: Kirill Lobachev & Jeff Owens

The PI addressed all reviewer concerns prior to the meeting. As such, the registration was reviewed and the committee had no further concerns.

VOTE: In favor – 5 Against – 0 Abstained – 0

R14023 PI: Brian Hammer Title: Regulation of natural transformation in Vibrio cholerae / NetSE:Large: MONACO: Fundamentals of Molecular Nano-Communication Networks Category: Non-Exempt; BSL2, ABSL1 Status: Under Review Reviewers: Jeff Owens & Deborah Cook

This lab is looking at Vibrio cholera signaling and manipulating the host using standard host- vector transmission with no change in the pathogenicity or virulence of the materials.

Comments from reviewers were sent to the PI for clarification prior to the meeting. The PI revised the registration and returned it to the IBC prior to the meeting.

The PI addressed all reviewer concerns prior to the meeting. As such, the registration was reviewed and the committee had no further concerns.

VOTE: In favor – 5 Against – 0 Abstained – 0

R14024 PI: Yuhong Fan Title: Role of Linker Histone H1 and Epignetic Gene Regulation Category: Non-Exempt; BSL2 Status: Under Review Reviewers: Kirill Lobachev & Deborah Cook

The PI addressed all reviewer concerns prior to the meeting. As such, the registration was reviewed and the committee had no further concerns.

VOTE: In favor – 5 Against – 0 Abstained – 0

3. Pending Registrations (New, continuing review, and amendments).

none

A Unit of the University System of Georgia. An Equal Education and Employment Opportunity Institution.

Georgia Institute of Technology Institutional Biosafety Committee (IBC) Office of Research Integrity Assurance [email protected] www.ibc.gatech.edu 4. Registrations, Modifications, Continuations, and Other Actions Approved at or since last Biosafety Committee Meeting

R12005 PI: Garrett Stanley Title: Evaluation of optogenetic stimulation within the rodent vibrissa somatosensory system Category: Non-Exempt; BSL2, ABSL1 Modification: addition of material Status: Approved

R14004 PI: Philip Santangelo Title: Characterization of mRNA based vaccine Category: Non-Exempt; BSL2 Modification: addition of material, experiments and containment update Status: Approved

R11009 PI: Loren Williams Title: Ribosoome: Construction and Deconstruction Category: Exempt; BSL1 Modification: Funding Status: Approved

5. Withdrawn or Closed Registrations since last IBC meeting

6. Other business

 Occ Health update from EH&S – the Occupational Health Committee approved the use of OnSite for the online submission for Occupational Health Enrollment and monitoring.  Institute Council is reviewing their charter and has requested that each committee do the same.  Biosafety is working with Stamps Health for Ebola protocols including PPE training.

7. Next meeting

TBD

A Unit of the University System of Georgia. An Equal Education and Employment Opportunity Institution.

Georgia Institute of Technology Institutional Biosafety Committee (IBC) Office of Research Integrity Assurance [email protected] www.ibc.gatech.edu