Research Information

RESEARCH INFORMATION

Name: Graham W. Aberdeen, Ph.D. Title: Assistant Professor Address: F.C. Bressler Research Bldg., Room 11-027 Phone: 410-706-3390 Fax: 410-706-5747 Email: [email protected]

Current Research Interests (2-4 sentences)

Estrogen regulation of placental and fetal development. Fetal programming of fetal vascular and adrenal development. Programming effects upon vascular development and insulin sensitivity in offspring.

Education B.Sc., Biology, University of Alberta, Edmonton, Alberta, Canada 1986 M.Sc., Physiology, McGill University, Montreal, Quebec, Canada 1992 Ph.D., Physiology/Reproductive Endocrinology, University of Maryland, Baltimore 1998

Current Committees/Professional Memberships Regular Member, Society for the Study of Reproduction (SSR) 2001 - present Regular Member. Society for Reproductive Investigation (SRI) 2005 – present Regular Member, Perinatal Research Society (PRS) 2010 - present Key Areas of Expertise Fetal/Perinatal Endocrinology Placental Development Fetal Development Key Skill/Technical Areas

In vivo experimental animal pregnancy models (NHP, Ovine, Guinea Pig). Functionality testing of physiological parameters in in vivo experimental animal model systems. Molecular biology (RT/PCR, PLA). Steroid and protein immunoassays (RIA & ELISA) Histology, immunocytochemistry, electron microscopy. Ultrasound (Doppler & contrast-enhanced). Laser capture microdissection. Various surgical approaches for model creation, experimental manipulation and tissue collections.

Key Collaborators

Eugene D. Albrecht, Ph.D. University of Maryland School of Medicine Gerald J. Pepe, Ph.D. Eastern Virginia Medical School

Inventions/Patents N/A

Research Links of Interest N/A

Research Support

NIH R01 DK93950-01 (Aberdeen, Co-Investigator) 04/01/2013 – 03/31/2017 “Primate Fetal Adrenal Development: Impact on Physiological Processed After Birth” Publications (last 2 years and no more than 2 pages)

Aberdeen GW, Bonagura TW, Harman CR, Pepe GJ, Albrecht ED. Suppression of trophoblast uterine spiral artery remodeling by estrogen during baboon pregnancy: Impact on uterine and fetal blood flow dynamics. Am J Physiol Heart Circ Physiol. 302(10): H1936-1944, 2012.

Bonagura TW, Babischkin JS, Aberdeen GW, Pepe GJ, Albrecht ED. Prematurely elevating estrogen in early baboon pregnancy suppresses uterine artery remodeling and expression of extravillous placental vascular endothelial growth factor and α1β1 and α5β1 integrins. Endocrinology 153(6): 2897-2906, 2012.

Kyathanahalli C, Marks J, Nye K, Lao B, Albrecht ED, Aberdeen GW, Nathanielsz PW, Jeyasuria P, Condon JC. Cross-Species withdrawal of MCL1 facilitates postpartum uterine involution in both the mouse and baboon. Endocrinology 154(12): 4873-4884, 2013.

Dumitrescu A, Aberdeen GW, Pepe GJ, Albrecht ED. Placental estrogen suppresses cyclin D1 expression in the nonhuman primate fetal adrenal cortex. Endocrinology 155(12): 4774-4784, 2014.

Wang F, Wu Y, Gu H, Reece EA, Fang S, Gabbay-Benviz R, Aberdeen GW, Yang P. Ask1 gene deletion blocks maternal diabetes-induced endoplasmic reticulum stress in the developing embryo by disrupting the unfolded protein response signalosome. Diabetes, 64(3): 973-988, 2015.