Table 2. Downregulated Genes in Dysbindin KO Mice Vs Wild Type Mice

Table 2. Downregulated genes in dysbindin KO mice vs Wild type mice

Gene Gene Symbol P-Value Fold Change GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Gnas 0.0049 -2.55 transmembrane protein 111 Tmem111 0.0013 -2.41 peroxiredoxin 2 Prdx2 0.0089 -2.40 microtubule-associated protein, RP/EB family, member 2 Mapre2 0.0161 -2.15 calpain, small subunit 1 Capns1 0.0133 -2.10 myosin IXa Myo9a 0.0289 -2.04 heat shock protein 8 Hspa8 0.0219 -2.00 tubulin, alpha 4A Tuba4a 0.0082 -1.94

RIKEN cDNA 6530411M01 gene 6530411M01Rik 0.0016 -1.90 transgelin 3 Tagln3 0.0092 -1.88 family with sequence similarity 135, member B Fam135b 0.0028 -1.88

RAB6B, member RAS oncogene family Rab6b 0.0089 -1.83

ATPase, Ca++ transporting, plasma membrane 3 Atp2b3 0.0020 -1.82 tetraspanin 7 Tspan7 0.0071 -1.82 transmembrane protein 63b Tmem63b 0.0086 -1.79 glutamate oxaloacetate transaminase 1, soluble Got1 0.0213 -1.78 glutamate oxaloacetate transaminase 2, mitochondrial Got2 0.0153 -1.78 mesoderm specific transcript Mest 0.0241 -1.77 carbonic anhydrase 10 Car10 0.0427 -1.77 isoleucine-tRNA synthetase Iars 0.0139 -1.74 activity regulated cytoskeletal-associated protein Arc 0.0493 -1.74 abhydrolase domain containing 6 Abhd6 0.0102 -1.73 ribosomal protein L15 | predicted gene 4294 | predicted gene 5292 Rpl15 0.0169 -1.73

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 Ndufa9 0.0233 -1.72

RIKEN cDNA 6430704M03 gene 6430704M03Rik 0.0028 -1.72 casein kinase 2, beta polypeptide Csnk2b 0.0126 -1.71 reticulon 1 Rtn1 0.0033 -1.70 tubulin, alpha 1B | tubulin, alpha 1C | predicted gene 5620 Tuba1b 0.0230 -1.69 ADP-ribosylation factor 1 Arf1 0.0210 -1.69 aldo-keto reductase family 1, member B3 (aldose reductase) Akr1b3 0.0120 -1.69

ATPase, Na+/K+ transporting, alpha 1 polypeptide Atp1a1 0.0042 -1.69

Sp140 nuclear body protein | RIKEN cDNA A530032D15Rik gene Sp140 0.0357 -1.68 oligonucleotide/oligosaccharide-binding fold containing 2B Obfc2b 0.0018 -1.68 ribosomal protein, large, P0 Rplp0 0.0041 -1.68 vacuolar protein sorting 28 (yeast) Vps28 0.0040 -1.68 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 Slc25a23 0.0067 -1.67 histone deacetylase 3 Hdac3 0.0056 -1.67 sodium channel, voltage-gated, type II, alpha 1 Scn2a1 0.0102 -1.67

S-adenosylhomocysteine hydrolase-like 2 Ahcyl2 0.0063 -1.67 ribosomal protein S4, X-linked Rps4x 0.0498 -1.66 like-glycosyltransferase Large 0.0130 -1.66

NADH dehydrogenase (ubiquinone) Fe-S protein 5 Ndufs5 0.0265 -1.66 COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana) Cops6 0.0182 -1.65 protein phosphatase 1, regulatory (inhibitor) subunit 11 Ppp1r11 0.0478 -1.64 lymphocyte antigen 6 complex, locus E Ly6e 0.0140 -1.64 serine/threonine kinase 25 (yeast) Stk25 0.0076 -1.64 calcium channel, voltage-dependent, R type, alpha 1E subunit Cacna1e 0.0112 -1.63 enolase 1, alpha non-neuron Eno1 0.0165 -1.62

MKL/myocardin-like 2 Mkl2 0.0011 -1.62

CKLF-like MARVEL transmembrane domain containing 5 Cmtm5 0.0194 -1.62 transmembrane protein 50B Tmem50b 0.0176 -1.61 tubulin tyrosine ligase-like 1 Ttll1 0.0301 -1.61 potassium voltage-gated channel, subfamily Q, member 5 Kcnq5 0.0069 -1.61

ATPase, H+ transporting, lysosomal accessory protein 1 Atp6ap1 0.0056 -1.61 protein tyrosine phosphatase, receptor type, J Ptprj 0.0084 -1.60 glyceraldehyde-3-phosphate dehydrogenase Gapdh 0.0049 -1.60 oxoglutarate dehydrogenase (lipoamide) Ogdh 0.0239 -1.60 serine racemase | TSR1, 20S rRNA accumulation, homolog (yeast) | similar to serine racemase Srr 0.0006 -1.60 Max protein Max 0.0195 -1.59

CAP, adenylate cyclase-associated protein, 2 (yeast) Cap2 0.0032 -1.59

CAP-GLY domain containing linker protein 3 Clip3 0.0085 -1.59

MORN repeat containing 4 Morn4 0.0074 -1.59 family with sequence similarity 125, member B Fam125b 0.0048 -1.59 internexin neuronal intermediate filament protein, alpha Ina 0.0487 -1.59 glutathione S-transferase, pi 1 Gstp1 0.0291 -1.59 ribosomal protein S2 | ribosomal protein S2 pseudogene Rps2 0.0274 -1.59

GRAM domain containing 1B Gramd1b 0.0031 -1.58

DNA segment, Chr 8, ERATO Doi 738, expressed D8Ertd738e 0.0007 -1.58 unc-80 homolog (C. elegans) Unc80 0.0159 -1.58 neuritin 1 Nrn1 0.0238 -1.58

LAG1 homolog, ceramide synthase 2 Lass2 0.0018 -1.58 synaptic Ras GTPase activating protein 1 homolog (rat) Syngap1 0.0135 -1.58 transmembrane protein 50A Tmem50a 0.0113 -1.57 malate dehydrogenase 2, NAD (mitochondrial) Mdh2 0.0173 -1.57 chromodomain helicase DNA binding protein 3 Chd3 0.0013 -1.57 glucose phosphate isomerase 1 Gpi1 0.0092 -1.57 synaptotagmin X Syt10 0.0035 -1.57 copine II Cpne2 0.0291 -1.57 cytochrome c oxidase subunit IV isoform 1 Cox4i1 0.0004 -1.56

RIKEN cDNA 4933407C03 gene 4933407C03Rik 0.0234 -1.56 protocadherin 9 Pcdh9 0.0235 -1.56

RIKEN cDNA 4932438A13 gene 4932438A13Rik 0.0489 -1.56

RIKEN cDNA 2610507B11 gene 2610507B11Rik 0.0055 -1.55 gamma-aminobutyric acid (GABA) B receptor, 2 Gabbr2 0.0097 -1.55

RIKEN cDNA 5730419I09 gene 5730419I09Rik 0.0108 -1.55 translocase of inner mitochondrial membrane 17a Timm17a 0.0229 -1.55 mitogen-activated protein kinase 10 Mapk10 0.0173 -1.55 transmembrane protein 170B Tmem170b 0.0128 -1.55 mannose phosphate isomerase Mpi 0.0086 -1.55 glutamate receptor, ionotropic, NMDA2B (epsilon 2) Grin2b 0.0389 -1.55 glutathione S-transferase, alpha 4 Gsta4 0.0374 -1.55 ribonucleoprotein, PTB-binding 2 Raver2 0.0137 -1.55 glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) Grina 0.0111 -1.54 proteasome (prosome, macropain) subunit, beta type 7 Psmb7 0.0327 -1.54 similar to alpha-tubulin isotype M-alpha-2 LOC100044416 0.0057 -1.54 ubiquitin carboxy-terminal hydrolase L1 Uchl1 0.0075 -1.54 cutA divalent cation tolerance homolog (E. coli) Cuta 0.0015 -1.54 transmembrane protein 178 Tmem178 0.0325 -1.54 archaelysin family metallopeptidase 2 Amz2 0.0069 -1.54 glyceraldehyde-3-phosphate dehydrogenase pseudogene Gm8055 0.0012 -1.54 acyl-CoA thioesterase 10 Acot10 0.0452 -1.54 nuclear transport factor 2 Nutf2 0.0074 -1.53 insulin induced gene 1 Insig1 0.0107 -1.53 melanoma antigen family B, 16 | predicted gene 15072 Mageb16 0.0403 -1.53 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 Gabrb3 0.0018 -1.53 monocyte to macrophage differentiation-associated Mmd 0.0214 -1.53 RIKEN cDNA 4930444G20 gene | cDNA sequence AF366264 | predicted gene 9839 | predicted gene 4831 4930444G20Rik 0.0082 -1.53 synaptotagmin XVII Syt17 0.0161 -1.53 family with sequence similarity 18, member B Fam18b 0.0360 -1.53 etoposide induced 2.4 mRNA Ei24 0.0188 -1.53 eukaryotic translation initiation factor 3, subunit H Eif3h 0.0088 -1.53

Rho family GTPase 2 Rnd2 0.0037 -1.53

L1 cell adhesion molecule L1cam 0.0039 -1.52

SLIT and NTRK-like family, member 1 Slitrk1 0.0127 -1.52 predicted gene 6517 Gm6517 0.0216 -1.52 glutamate receptor, ionotropic, NMDA2A (epsilon 1) Grin2a 0.0222 -1.52 predicted gene 7172 Gm7172 0.0052 -1.52

ATPase, H+ transporting, lysosomal V0 subunit D1 Atp6v0d1 0.0261 -1.52 ubiquitin-conjugating enzyme E2Q (putative) 1 Ube2q1 0.0109 -1.52 solute carrier family 2 (facilitated glucose transporter), member 13 Slc2a13 0.0007 -1.51

TMF1-regulated nuclear protein 1 Trnp1 0.0033 -1.51 solute carrier family 7 (cationic amino acid transporter, y+ system), member 14 Slc7a14 0.0042 -1.51

RIKEN cDNA 4930455F23 gene 4930455F23Rik 0.0124 -1.51 diacylglycerol kinase, beta Dgkb 0.0192 -1.51 ubiquitin A-52 residue ribosomal protein fusion product 1 | predicted gene 11808 | ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene | RIKEN cDNA 2810422J05 gene Uba52 0.0133 -1.51 predicted gene 3579 LOC433762 0.0276 -1.51 phosphodiesterase 2A, cGMP-stimulated Pde2a 0.0134 -1.51

WD repeat domain 7 Wdr7 0.0012 -1.51 hydroxysteroid (17-beta) dehydrogenase 10 Hsd17b10 0.0043 -1.51 phospholipase D family, member 3 Pld3 0.0205 -1.51 presenilin associated, rhomboid-like Parl 0.0431 -1.51

Dmx-like 2 Dmxl2 0.0300 -1.51

ADP-ribosylation factor 3 Arf3 0.0114 -1.51 ribosomal protein L18 Rpl18 0.0018 -1.51

Fas apoptotic inhibitory molecule 2 Faim2 0.0475 -1.50

PTK2 protein tyrosine kinase 2 beta Ptk2b 0.0003 -1.50 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 Slc24a3 0.0047 -1.50

ATPase, Na+/K+ transporting, beta 1 polypeptide Atp1b1 0.0067 -1.50