Renyuan Li1*, Xu Wen1*, Sihui Luo1, Haixia Xu1, Guoyu Tong2, Longyi Zeng1, Dalong Zhu2
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Acta Diabetologica
Effect of Exenatide, Insulin and Pioglitazone on Bone Metabolism in Patients with Newly
Diagnosed Type 2 Diabetes
Renyuan Li1*, Xu Wen1*, Sihui Luo1, Haixia Xu1, Guoyu Tong2, Longyi Zeng1, Dalong Zhu2, Jianping Weng1 From the 1Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, the Third Affiliated Hospital of Sun Yat-Sen University Guangzhou, China; 2Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China;
* These authors contributed equally.
Correspondence:
Dr. Jianping Weng
Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology
The Third Affiliated Hospital of Sun Yat-sen University
No. 600 Tianhe Road
Guangzhou, 510630
China
Tel: +86 2085253162
Fax: +862085252107
Email: [email protected] Supplementary data
Supplementary Table 1. Titration scheme of insulin dosage for patients in insulin group
Fasting / pre-dinner glucose (mmol/L) Dosage titration <4.4 -2 U 4.4–7.0 No titration 7.0–8.0 +2 U 8.0–10.0 +4 U >10.0 +6 U Supplementary Table 2. Adverse events Exenatide Insulin Pioglitazone Adverse event (n = 20) (n = 21) (n = 21)
Nausea 7 (35.0) 1 (4.8) 0
Dizziness 5 (25.0) 1 (4.8) 2 (9.5)
Vomiting 1 (5.0) 0 0
Abdominal distension 4(20.0) 0 0
Appetite loss 2 (10.0) 0 0
Diarrhea 3 (15.0) 0 1 (4.8)
Upper respiratory tract infection 3 (15.0) 5 (23.8) 2 (9.5)
Edema 0 0 2 (9.5)
Numbness 0 1 (4.8) 1 (4.8)
Fatigue 1 (5.0) 0 1 (4.8)
Injection-site reaction 3 (15.0) 2 (9.5) 0
Palpitations 0 0 1 (4.8)
Constipation 2 (10.0) 0 0
Headache 3(15.0) 0 1 (4.8)
Blurred vision 1 (5.0) 1 (4.8) 2 (9.5)
Arthralgia 0 1 (4.8) 2 (9.5)
Chest tightness 0 0 1 (4.8)
Rash 0 2 (9.5) 1 (4.8) Bone fracture 0 0 0
Skelalgia 2 (10.0) 1 (4.8) 0
Toothache 2 (10.0) 0 0
Weight gain 0 0 0
Allergy 0 1 (4.8) 0
Data are n (%) of intention-to-treat population