Motor Unit and Electromyogram (EMG ) s3

I] Responsible Screening Practices…

The SynBio Report asserts that many though not all commercial gene synthesis firms screen sequences before actually synthesizing DNA. This The screening involvesing comparing comparison of a sequence to known “dangerous” sequences, i.e., i.e. sequences which that confer pathogennicity, or which to sequences that could increase the stability ies and persistences of the engineered organism in the environment. Screening is routinely carried out by means ofusing commercially available softwares like the Craic Blackwatch software

(http://biotech.craic.com/blackwatch/). The system is not however not foolproof, and continuous updates again and again must always be made to the screening softwares to include recently uncovered “‘dangerous’” sequences in a the screening parameters.

Screen These screening practices of this type have evolveds independently of any regulatory interventionoversight , and they represent thean industry standard. Therefore, logically the next step would be logically are, to enforce and evolve and enforce these standards through meaning of appropriate regulation. This can be done achieved onat twobi levels:

 The biosafety legislation of various international nationsindividual countries could be corrected

amended to require gene synthesis firms and research organizsations operating within their

territories of jurisdiction to carry out screening for dangerous sequences in accordance, to the

international industry standard (called the Best-Practice Procedures in the SynBio Report). An

independent regulateory body may be authorizsed by legislation to determine the very

largedifferent aspects of the screening programme, thus allowing the standards to grow

evolve big as more information becomes available. This regulatory body should require

toshould be confer with researchers, universitieses, and all other interested parties before

approving a standarda for compliance by novel standard is evolvedthe gene synthesis firms

and being imposed on companies. The regulatorye body organization can thus be empowered

to generate a “‘watching list”’ of potentially dangerous sequences, which can then be

incorporated into standard gene sequence screening software.

All material in this document is the intellectual property of Crimson Interactive Pvt. Ltd. The use of information and content in this document in whole or in part is forbidden unless express permission has been given in writing by Crimson Interactive Pvt. Ltd. www.enago.com | www.enago.jp | www.enago.com.tr | www.enago.com.br | www.enago.de | www.enago.tw www.enago.cn | www.enago.ae  The Cartagena Protocol on Biosafety, a protocol of the Convention on Biological Diversity,

may serve serve as the abest temp late to for regulating synthetic biology on at the

international level.

All material in this document is the intellectual property of Crimson Interactive Pvt. Ltd. The use of information and content in this document in whole or in part is forbidden unless express permission has been given in writing by Crimson Interactive Pvt. Ltd. www.enago.com | www.enago.jp | www.enago.com.tr | www.enago.com.br | www.enago.de | www.enago.tw www.enago.cn | www.enago.ae