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NES/ASAP Pharmacy Vocational Training Scheme Specialist module Infection and Antimicrobial Stewardship

Stage 3 Resources January 2014 v1.5

1 Please note that, with the exception of text books, the majority of resources within these lists will be available free of charge. Those which require either free registration or require a fee to be paid are annotated accordingly.

It is assumed that all participants will have registered with The Knowledge Network (TKN) and will have an Athens Password. Many of the URL links for such resources should link you direct to the article once you have entered your Athens password - if this fails, you should be able to access the article yourself via TKN.

Articles from the Journal of Antimicrobial Chemotherapy are available on the BSAC website or via TKN

There are a few resources listed which are on the YouTube platform and may not be accessible from NHS premises. These may require to be viewed from home or on a personal electronic device.

For webinars and videos the approximate running time is given in brackets after the name of the presentation

We would welcome your feedback - please contact NES Pharmacy if you have any comments about these resources or if you have trouble accessing any of the key resources.

2 Contents Page number

Bibliography 5 Suggested texts - to be used for background knowledge as available locally for appropriate elements

Element 1 Introduction to Antimicrobial Stewardship Core resources 7

Element 2 Essential microbiology, resistance and basic immune function 11

Element 3 Antimicrobial agents by therapeutic class 15

Element 4 Healthcare Acquired Infection (HAI) 17

Element 5 Sepsis Diagnosis and Management 21

Element 6 Acute respiratory tract infection incorporating pneumonia and 23 COPD Element 7 - Urinary tract infection (UTI) 26

Element 8 Skin and soft tissue infection (SSTI) 29

Element 9 Surgical infection & prophylaxis 33

Element 10 Pharmacokinetics (PK) pharmacodynamics (PD) and 35 therapeutic drug monitoring (TDM)

Element 11 Data analysis and presentation Incorporating interpretation of 39 audit data Element 12 Meningitis and CNS Infection 41

Element 13 Endocarditis and Cardiovascular Infection 44

Element 14 Bone & Joint Infections 46

3 Element 15 Gastrointestinal (GI) infections 48

Element 16 - Antibiotics used in pregnancy, neonates and paediatrics 51

Element 17 Sexually transmitted infection (STI), human immunodeficiency 56 virus (HIV) & other blood borne virus (BBV)

Element 18 Tropical infectious diseases 62

Element 19 Chronic respiratory tract infections - tuberculosis (TB), cystic 65 fibrosis (CF) and non-CF bronchiectasis

Element 20 Fungal infections 68

Element 21 Outpatient parenteral antimicrobial therapy (OPAT) 70

4 Bibliography Suggested texts - to be used for background knowledge as available locally for appropriate elements Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments 210 Antimicrobial Chemotherapy 6th Ed 2012 if available Oxford University Finch RG Press 219 Sanford Guide 2013 if available Antimicrobial Gilbert et al http://www.sanfordguide.com/ Therapy Inc (Eds) 296 Manual of Clinical microbiology 9th Ed 2007 (on TKN) ASM press Murray PR et al https://www.123library.org/bookdetails/?id=2814 299 Reese & Betts' practical approach to infectious diseases Lippincott Williams Betts RF et al http://www.knowledge.scot.nhs.uk/home/library/books/ 5th Ed 2003 (on TKN) and Wilkins books-results.aspx?q=ctitle:(string(%22reese %22%2c+mode%3d%22and%22)+and+string(%22betts %22%2c+mode%3d%22and %22))&pm=fql&title=reese+and+betts&srt=rptitle100sub 50bod20 329 Kucers' The Use of Antibiotics 6th Ed if available ASM Press & Hodder Grayson ML Arnold 330 Principles and Practice of Infectious Diseases 7th Ed if Elsevier Churchill Mandell GL et al available Livingstone 292 Notes on medical Microbiology 4th Ed 2002 if available Churchill Livingstone Timbury MC et al 293 Clinical bacteriology 2003 if available Manson Publishing Struthers JK et al 384 Infection and Immunity 3rd Ed 2008 or 4th Ed 2013 if Oxford University Playfair J available Press Bancroft G 385 Basic & Clinical Immunology if available Churchill Livingstone Peakman M Vergani D 374 British National Formulary (BNF) BMJ/RPS http://www.medicinescomplete.com/about/index.htm 375 British National Formulary for Children (BNF-C) BMJ/RPS http://www.medicinescomplete.com/about/index.htm 442 Stockley's Drug Interactions (Via TKN) Medicines Complete http://www.medicinescomplete.com/mc/stockley/curren 5 Suggested texts - to be used for background knowledge as available locally for appropriate elements Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments t/ 301 ABC of Sepsis 2010 if available - comes highly BMJ Books Wiley Daniels R recommended Blackwell 378 Infectious Diseases of the Fetus and Newborn (7th Elsevier Remington J et http://www.amazon.co.uk/dp/1416064001/ref=rdr_ext_t Edition) if available al mb 479 Medications and Mothers' Milk 2012 if available Hale Publishing Hale T 440 Neonatal Formulary (6th ED) with updates 2011 if Wiley Hey E (Editor) http://www.neonatalformulary.com/default.asp available 376 Drugs in Pregnancy and Lactation: A Reference Guide to Lippincott Williams & Briggs G http://www.knowledge.scot.nhs.uk Fetal and Neonatal Risk 9th ed (via TKN) Wilkins 302 ABC of HIV and AIDS 6th Ed 2012 if available (comes BMJ Books Wiley Alder MW highly recommended but would need to be purchased) Blackwell 346 Oxford Handbook of Tropical Medicine 2005 (New Oxford Press Eddleston M et http://www.talcuk.org/books/oxford-handbook-of- edition published in 2014) if available al tropical-medicine-3rd-edition.htm 430 Manson's Tropical Diseases 23rd Ed 2013 if available Elsevier Farrar J et al (Ed) 429 Hunter's Tropical Medicine and Emerging Infectious Elsevier Magill AJ et al Disease: Expert Consult -2013 Online and Print, 9e if (ED) available 501 Oxford Textbook of Medicine 2003 (via TKN) Oxford University Warrell D Ed www.knowledge.scot.nhs.uk Press

6 Resources for Element 1 Introduction to Antimicrobial Stewardship CORE RESOURCES Element 1 - INTRODUCTION TO ANTIMICROBIAL STEWARDSHIP - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments SAPG & SCOTTISH GOVERNMENT REFERENCES Scottish Antimicrobial Prescribers Group (SAPG) website Scottish Medicines SAPG http://www.scottishmedicines.org.uk/SAPG/Scottish_Anti Consortium microbial_Prescribing_Group__SAPG_ 8 Training on Use of Antimicrobials in Clinical Practice NES HIS/SAPG http://www.nes.scot.nhs.uk/education-and-training/by- (SAPG) (60 mins) theme-initiative/healthcare-associated- infections/training-resources/antimicrobials-in-clinical- practice.aspx 107 Good Practice Recommendations for Antimicrobial Use SAPG SAPG http://www.scottishmedicines.org.uk/files/sapg/SAPG_Re in Frail Elderly Patients in NHS Scotland commendations_for_antibiotic_use_in_frail_elderly_- _February_2013.pdf 121 SAPG Good Practice Recommendations for Hospital SAPG SAPG http://www.scottishmedicines.org.uk/files/sapg/Good_pr Antimicrobial Stewardship in NHS Scotland actice_recommendations_for_hospital_antimicrobial_ste wardship_2012.pdf 138 Scot MARAP 2008 (Due for update in 2013/14) Scottish Government http://www.scotland.gov.uk/Publications/2008/03/12153 030/0

LOCAL HEALTH BOARD REFERENCES Local health board website or intranet

OTHER ANTIMICROBIAL STEWARDSHIP REFERENCES 140 Guidelines for Developing an Institutional Program to Clinical Infectious Dellit TH et al http://www.idsociety.org/Antimicrobial_Agents/#Antimic Enhance Antimicrobial Stewardship Diseases 2007; robial Stewardship 44:159–77 390 Antimicrobial Stewardship Start Smart then Focus Department of https://www.gov.uk/government/publications/antimicro Health bial-stewardship-start-smart-then-focus

7 Element 1 - INTRODUCTION TO ANTIMICROBIAL STEWARDSHIP - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments SCOTTISH PATIENT SAFETY PROGRAMME REFERENCES 489 Scottish Patient Safety Programme Website SPSP Health http://www.scottishpatientsafetyprogramme.scot.nhs.uk Improvement /programme Scotland

8 SUPPLEMENTARY RESOURCES Element 1 INTRODUCTION TO ANTIMICROBIAL STEWARDSHIP - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner URL link direct to resource /Author Comments SAPG & SCOTTISH GOVERNMENT REFERENCES 118 SAPG Good Practice Guidance on Ratification of SAPG SAPG http://www.scottishmedicines.org.uk/files/GOOD_PRACTI Antimicrobial Policies CE_GUIDANCE_ON_RATIFICATION_OF_ANTIMICROBIAL_P OLICIES.pdf 114 Recommendations for Good Antimicrobial Practice in Scottish Government http://www.scotland.gov.uk/Resource/Doc/69582/00170 Acute Hospitals 2005 99.pdf 110 (SAPG): development and impact of the Scottish Int J Antimicrob Nathwani D et al http://www.sciencedirect.com/science/article/pii/S09248 National Antimicrobial Stewardship Programme (via Agents 2011; 38(1): 57911001026 TKN) 16-26 113 Antimicrobial stewardship in Scotland: impact of a Antimicrob Res Inf Nathwani D et al http://www.aricjournal.com/content/1/1/7 national programme Cont 2012, 1:7

OTHER ANTIMICROBIAL STEWARDSHIP REFERENCES 19 Antibiotics and their role in Managing Infections (11 NES NES Portal http://www.nes.scot.nhs.uk/education-and-training/by- hours to complete full module - can dip in for specific discipline/pharmacy/about-nes-pharmacy/educational- subjects) resources/resources-by-topic/infectious- diseases/antibiotics/antibiotics-and-their-role-in- managing-infections.aspx 109 From intermittent antibiotic point prevalence surveys to Antimicrob Res Inf Malcolm W et al http://www.aricjournal.com/content/2/1/3 quality improvement: experience in Scottish hospitals Cont 2013;2:3 117 Antimicrobial Stewardship in Australian Hospitals ACSQH Duguid M http://www.scottishmedicines.org.uk/files/sapg/Australia Cruikshank M _Antimicrobial_Stewardship_2011.pdf 230 Annual Report of the Chief Medical Officer 2011: Department of Davies S https://www.gov.uk/government/publications/chief- Volume Two Health medical-officer-annual-report-volume-2

This publication provides a comprehensive overview of the threat of antimicrobial resistance and infectious diseases. 9 Element 1 INTRODUCTION TO ANTIMICROBIAL STEWARDSHIP - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner URL link direct to resource /Author Comments 231 The missing care bundle: antibiotic prescribing in Int J Ant Agents 2007; Cooke FJ et al http://www.ijaaonline.com/article/S0924- hospitals (via TKN or Athens login) 30:25-29 8579(07)00146-X/abstract 187 Interventions to improve antibiotic prescribing practices CDSR 2013, Issue 4. Davey P et al http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD for hospital inpatients (via TKN or Athens login) Art. No.: CD003543. 003543.pub3/abstract 305 Effectiveness of the interventions in antimicrobial ASAP Shared Space Davey P http://www.elib.scot.nhs.uk/SharedSpace/pharmacy/Upl stewardship: What works? Updated Cochrane oads/2013/Jun/20130614155109_Cochrane%20Webinar systematic review and systematic review methodology %20PDavey.pdf (via TKN) (60 mins) 306 Understanding the Determinants of Antimicrobial Clin Infect Dis. (2013) Charani E et al http://cid.oxfordjournals.org/content/57/2/188.long Prescribing Within Hospitals: The Role of “Prescribing 57 (2): 188-196 Etiquette”

10 Resources for Element 2 Essential microbiology, resistance and basic immune function CORE RESOURCES Element 2 - ESSENTIAL PHARMACEUTICAL MICROBIOLOGY, BACTERIAL RESISTANCE & BASIC IMMUNE FUNCTION - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner URL link direct to resource /Author Comments MICROBIOLOGY & LAB REFERENCES 1 Bugs and Drugs Part 1 (30 mins) NES Kieran Hand http://www.nes.scot.nhs.uk/education-and-training/by- discipline/pharmacy/about-nes-pharmacy/educational- resources/webinars-and-virtual-patient- scenarios/webcasts/bugs-and-drugs-part-1.aspx 15 Basic Microbiology (2 hours) NES NES/LearnPro http://www.nes.scot.nhs.uk/education-and-training/by- theme-initiative/healthcare-associated-infections/online- short-courses/basic-microbiology.aspx 337 A Microbiologists View of Bugs & Drugs for ASAP (50 NES Alistair Leonard http://www.nes.scot.nhs.uk/education-and-training/by- mins) discipline/pharmacy/about-nes-pharmacy/educational- resources/resources-by-topic/infectious- diseases/antibiotics/a-microbiologists-view-of-bugs-and- drugs-for-asap.aspx 436 An insight into the National Reference Laboratory (47 NES John Coia http://vimeo.com/79495839 mins)

BACTERIAL RESISTANCE REFERENCES 12 Bacterial Resistance (2 hours) NES NES/LearnPro http://www.nes.scot.nhs.uk/education-and-training/by- theme-initiative/healthcare-associated-infections/online- short-courses/bacterial-resistance.aspx 13 Multi-resistant Gram Negative Bacilli (MRGNB) (15 NES NES/LearnPro http://www.nes.scot.nhs.uk/education-and-training/by- mins) theme-initiative/healthcare-associated-infections/online- short-courses/multi-resistant-gram-negative-bacilli- (mrgnb).aspx 138 Scot MARAP 2008 due for update in 2013/14 Scottish Government http://www.scotland.gov.uk/Publications/2008/03/12153

11 Element 2 - ESSENTIAL PHARMACEUTICAL MICROBIOLOGY, BACTERIAL RESISTANCE & BASIC IMMUNE FUNCTION - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner URL link direct to resource /Author Comments 030/0

BASIC IMMUNE FUNCTION REFERENCES 386 Clinical Guidelines for Immunoglobulin Use 2nd Ed Department of http://www.nsd.scot.nhs.uk/Documents/clinimmumoMar update March 2012 Health ch12.pdf 101 Your Immune System 101: Introduction to Clinical UCSF Dr Katherine http://www.youtube.com/watch? Immunology (YouTube - skip adverts) (90 mins) Gundling v=_oI0jVN4TTI&feature=player_detailpage 102 Basic Immunology - Nuts and Bolts of the Immune UCSF Dr Anthony De http://www.youtube.com/watch? System (YouTube - skip adverts) (90 mins) Franco feature=player_detailpage&v=mFNxXfwlP3A

SUPPLEMENTARY RESOURCES Element 2 - ESSENTIAL PHARMACEUTICAL MICROBIOLOGY, BACTERIAL RESISTANCE & BASIC IMMUNE FUNCTION - SUPPLEMENTARY RESOURCES

Resource Presenter Date Resource Name of resource Resource owner URL link direct to resource ID /Author Accessed/ Comments MICROBIOLOGY & LAB REFERENCES 466 BSAC Methods for Antimicrobial Susceptibility Testing BSAC BSAC http://bsacstage.pharma-mix.com////wp- Version 12 May 2013 content/uploads/2012/02/Version-12-Apr-2013_final.pdf 207 Guidelines on the laboratory diagnosis and J Antimicrob Brown DFJ et al http://jac.oxfordjournals.org/content/56/6/1000.full.pdf susceptibility testing of MRSA Chemother 2005; 56: 1000 - 1018 221 Guidance on the diagnosis and management of PVL- HPA/DoH HPA/DoH http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/12 associated Staphylococcus aureas infection 2008 18699411960 52 BSAC antimicrobial susceptibility testing – from Stokes BSAC Dr Derek Brown http://bsac.org.uk/events/past-events-2011/spring- to European harmonization to world? (20 mins) meeting-agm-2011/spring-meeting-2011/

BACTERIAL RESISTANCE REFERENCES

12 Element 2 - ESSENTIAL PHARMACEUTICAL MICROBIOLOGY, BACTERIAL RESISTANCE & BASIC IMMUNE FUNCTION - SUPPLEMENTARY RESOURCES

Resource Presenter Date Resource Name of resource Resource owner URL link direct to resource ID /Author Accessed/ Comments 276 Rapid evolution and spread of carbapenemases Eur Clin Microbiol Canton R et al http://onlinelibrary.wiley.com/doi/10.1111/j.1469- among Enterobacteriaceae in Europe (TKN or Athens Infect 2012;18: 413– 0691.2012.03821.x/abstract login) 431 278 Has the era of untreatable infections arrived? J Antimicrob Livermore DM http://jac.oxfordjournals.org/content/64/suppl_1/i29.full. Chemother 2009;64 pdf+html Suppl1:i29-i36 7 Patterns of Antimicrobial Use and Resistance in NES William Malcolm http://www.video3uk.com/login.aspx Scotland(MSc) (56 mins) 20 Avoiding Antibiotic Resistance: the role of the NES NES Portal http://www.nes.scot.nhs.uk/education-and-training/by- pharmacy team (NB quite old resource, may soon be discipline/pharmacy/about-nes-pharmacy/educational- replaced) (6 hours to complete whole module - can resources/resources-by-topic/infectious- dip in for specific subjects) diseases/antibiotics/avoiding-antibiotic-resistancethe- role-of-the-pharmacy-team.aspx 44 What is happening now? Epidemiology of resistance BSAC Prof Neil http://bsac.org.uk/events/past-events-2013/bsac-spring- (20 mins) Woodford meeting-2013/bsac-spring-meeting-agm-2013-videos/ 45 Carbapenemases in Practice (29 mins) BSAC Dr Andrew http://bsac.org.uk/events/past-events-2013/bsac-spring- Dodgson meeting-2013/bsac-spring-meeting-agm-2013-videos/ 46 Neisseria gonorrhea – the first untreatable infection BSAC Prof Catherine http://bsac.org.uk/events/past-events-2013/bsac-spring- (20 mins) Ison meeting-2013/bsac-spring-meeting-agm-2013-videos/ 48 VRE – one difficult Gram positive after another. BSAC Dr Nick Brown http://bsac.org.uk/events/past-events-2013/bsac-spring- Treatment options for severe infections (26 mins) meeting-2013/bsac-spring-meeting-agm-2013-videos/ 49 Optimisation of combination therapy for treatment of BSAC Dr Alexander http://bsac.org.uk/events/past-events-2013/bsac-spring- Pseudomonas aeruginosa (10 mins) Cochrane meeting-2013/bsac-spring-meeting-agm-2013-videos/ 51 New Uses for Old Agents (25 mins) BSAC Dr Kieran Hand http://bsac.org.uk/events/past-events-2013/bsac-spring- meeting-2013/bsac-spring-meeting-agm-2013-videos/ 60 Antibiotic cycling - a worthwhile weapon against gram BSAC Bob Masterton http://www.online-web-presentations.com/BSAC_2010/ negative resistance? (30 mins) 111 Overview of strategies for overcoming the challenge Expert Rev. Clin. Davey P et al http://www.scottishmedicines.org.uk/files/sapg/Davey_2 of antimicrobial resistance Pharmacol. 3(5), 010.pdf 13 Element 2 - ESSENTIAL PHARMACEUTICAL MICROBIOLOGY, BACTERIAL RESISTANCE & BASIC IMMUNE FUNCTION - SUPPLEMENTARY RESOURCES

Resource Presenter Date Resource Name of resource Resource owner URL link direct to resource ID /Author Accessed/ Comments 667–686 (2010) 209 Effective antibacterials: at what cost? The economics J. Antimicrob. WhiteAR http://jac.oxfordjournals.org/content/66/9/1948.full.pdf of antibacterial resistance and its control Chemother.2012; 66: 1948-1953 212 Risks of extended-spectrum beta-lactamases (via DTB 2008;46:21-24 http://dtb.bmj.com/content/46/3/21.full TKN/Athens login) 222 The evolving threat of antimicrobial resistance WHO http://whqlibdoc.who.int/publications/2012/9789241503 181_eng.pdf 223 The Future of antibiotics resistance n engl j med 368;4 Spellberg B et al http://www.nejm.org/doi/pdf/10.1056/NEJMp1215093 nejm.org january 24, 2013 271 Antibiotic Prescribing - Reduce and Resist (via TKN) ASAP Shared Space Philip C http://www.elib.scot.nhs.uk/SharedSpace/pharmacy/Upl oads/2010/Sep/20100922142033_quiz%20section %20Reduce%20and%20resist%20section%202010.pdf 275 Susceptibility of Klebsiella pneumoniae Isolates from Antimicrob Agents Hawser SP et al http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147618/ Intra-Abdominal Infections and Molecular Chemother. 2011 Characterization of Ertapenem-Resistant Isolates 55(8): 3917–3921

BASIC IMMUNE FUNCTION REFERENCES 379 Immunisation against infectious disease: the Green Department of https://www.gov.uk/government/organisations/public- Book Health health-england/series/immunisation-against-infectious- disease-the-green-book 384 Infection and Immunity 3rd Ed 2008 or 4th Ed 2013 if Oxford University Playfair J available Press Bancroft G 385 Basic & Clinical Immunology if available Churchill Livingstone Peakman M Vergani D

14 Resources for Element 3 Antimicrobial agents by therapeutic class CORE RESOURCES

Element 3 - ANTIBIOTICS BY THERAPEUTIC CLASS - CORE RESOURCES Date Resource Presenter Accessed/ Resource ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL CLASSIFICATION OF ANTIBIOTICS REFERENCES AND LOCAL GUIDELINES Local Antimicrobial Prescribing Guidelines 2 Bugs and Drugs Part 2 (35 mins) NES Kieran Hand http://www.nes.scot.nhs.uk/education-and- training/by-discipline/pharmacy/about-nes- pharmacy/educational-resources/webinars-and- virtual-patient-scenarios/webcasts/bugs-and-drugs- part-2.aspx 443 Electronic Medicines Compendium eMC Datapharm http://www.medicines.org.uk/emc/ 219 Sanford Guide 2013 if access available (subscription Antimicrobial Gilbert et al http://www.sanfordguide.com/ or purchase required) Therapy Inc (Eds) 374 British National Formulary (BNF) BMJ/RPS http://www.medicinescomplete.com/about/index.ht m

ADVERSE DRUG REACTIONS & INTERACTIONS REFERENCES 442 Stockley's Drug Interactions (via TKN) Medicines Complete http://www.medicinescomplete.com/mc/stockley/c urrent/ 467 Yellow Card Reporting Website MHRA MHRA http://yellowcard.mhra.gov.uk/

15 SUPPLEMENTARY RESOURCES Element 3 - ANTIBIOTICS BY THERAPEUTIC CLASS - SUPPLEMENTARY RESOURCES

Resource Presenter Date Resource Name of resource Resource owner URL link direct to resource ID /Author Accessed/ Comments GENERAL CLASSIFICATION OF ANTIBIOTICS REFERENCES AND LOCAL GUIDELINES 19 Antibiotics and their role in Managing Infections NES NES Portal http://www.nes.scot.nhs.uk/education-and-training/by- (May soon be superseded on NES website) discipline/pharmacy/about-nes-pharmacy/educational- resources/resources-by-topic/infectious- diseases/antibiotics/antibiotics-and-their-role-in- managing-infections.aspx 125 Management of infection guidance for primary care HPA http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1 HPA 279888711402 215 Gentamicin ototoxicity: a 23 year selected case series MJA June 2012 ; Ahmed RM et al https://www.mja.com.au/journal/2012/196/11/gentami of 103 patients 196(11) 701-05 cin-ototoxicity-23-year-selected-case-series-103-patients 217 2005-2006 Field Guide to Antibiotic Therapy Drug Topics Astra http://www.zubnistranky.cz/atb.pdf Zeneca 218 Carbapenem Antibiotics for serious infections (via BMJ 2012;344:e3236 Hawkey PM et al http://www.bmj.com/content/344/bmj.e3236 TKN or Athens login) 220 Johns Hopkins ABX Guide (subscription required - Unbound Medicine http://www.hopkinsguides.com/hopkins/ub/index/John some MI centres may subscribe) Inc s_Hopkins_ABX_Guide/All_Topics/A 441 UKCPA Drug Dosing in Extremes of Body Weight in UKCPA Need a hyperlink to this once it is on the NES website Critically Ill Patients 2013

16 Resources for Element 4 Healthcare Acquired Infection (HAI) CORE RESOURCES Element 4 - HEALTHCARE ASSOCIATED INFECTION (HAI) - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments HAI GENERAL REFERENCES 387 HPS Compendium of Healthcare Associated Infection Health Protection http://www.hps.scot.nhs.uk/haiic/publicationsdetail.aspx Guidance Scotland ?id=47911

CDI REFERENCES 3 Bugs and Drugs Part 3 Clostridium difficile associated NES Kieran Hand http://www.nes.scot.nhs.uk/education-and-training/by- disease (CDAD) (15 mins) discipline/pharmacy/about-nes-pharmacy/educational- resources/webinars-and-virtual-patient- scenarios/webcasts/bugs-and-drugs-c-difficile.aspx 10 Clostridium difficile HIA Learning Tutorial (2 hours) NES NES/LearnPro http://www.nes.scot.nhs.uk/education-and-training/by- theme-initiative/healthcare-associated-infections/online- short-courses/c-difficile-a-clinical-tutorial.aspx 11 Clostridium difficile HAI Clinical Scenario (60 mins) NES NES/LearnPro http://www.nes.scot.nhs.uk/education-and-training/by- theme-initiative/healthcare-associated-infections/online- short-courses.aspx 327 C Difficile Associated Disease Clinical Vignette (20) (free PAUSE BSAC http://www.pause-online.org.uk registration for HCPs) (2 hours) 437 Guidance on Prevention and Control of Clostridium HPS HPS http://www.documents.hps.scot.nhs.uk/about- difficile Infection (CDI) in Healthcare Settings in hps/hpn/clostridium-difficile-infection-guidelines.pdf Scotland 388 SMC Advice on fidaxomicin Scottish Medicines https://www.scottishmedicines.org.uk/SMC_Advice/Advic Consortium e/791_12_fidaxomicin_dificlir/fidaxomicin_Dificlir

SABs / MRSA REFERENCES 283 Clinical Practice Guidelines for the Diagnosis and Clinical Infectious Mermel LA et al http://cid.oxfordjournals.org/content/49/1/1.full Management of Intravascular Catheter-Related Diseases 17 Element 4 - HEALTHCARE ASSOCIATED INFECTION (HAI) - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments Infection: 2009 Update by the Infectious Diseases 2009;49(1):1-45 Society of America (note corrigendum) 319 MRSA Treatment Errors Clinical Vignette (12) (free PAUSE BSAC http://www.pause-online.org.uk registration for HCPs) (60 mins) 325 IV Catheter Related Infection Clinical Vignette (18) (free PAUSE BSAC http://www.pause-online.org.uk registration for HCPs) (2 hours) 17 MRSA An Online Tutorial (3 hours) NES NES/LearnPro http://www.nes.scot.nhs.uk/education-and-training/by- theme-initiative/healthcare-associated-infections/online- short-courses/mrsa-a-clinical-tutorial.aspx 18 MRSA Clinical Scenario (2 hours) NES NES/LearnPro http://www.nes.scot.nhs.uk/education-and-training/by- theme-initiative/healthcare-associated-infections/online- short-courses/mrsa-a-clinical-scenario.aspx 22 Preventing Catheter Related Bloodstream Infections (60 NES NES/LearnPro http://www.nes.scot.nhs.uk/education-and-training/by- mins) theme-initiative/healthcare-associated-infections/online- short-courses/preventing-catheter-related-bloodstream- infections.aspx 391 Staphyloccus Aureus Bacteraemia Algorithm and SAPG SAPG http://www.scottishmedicines.org.uk/SAPG/Quality_Impr Quality Indicators 2012/13 ovement/Staph_aureus_bacteraemia 203 Guidelines (2008) for the prophylaxis and treatment of J. Antimicrob. Gould FK et al http://jac.oxfordjournals.org/content/63/5/849.full.pdf methicillin-resistant Staphylococcus aureus (MRSA) Chemother., May infections in the United Kingdom 2009; 63: 849 - 861

18 SUPPLEMENTARY RESOURCES Element 4 - HEALTHCARE ASSOCIATED INFECTION (HAI) - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments HAI GENERAL REFERENCES 6 Healthcare Associated Infection (MSc) NES Jacqueline http://www.nes.scot.nhs.uk/education-and- (free registration required) (45 mins) Sneddon training/by-discipline/pharmacy/about-nes- pharmacy/educational-resources/webinars-and- virtual-patient-scenarios/webinars.aspx 389 Scottish Government HAI Task Force Scottish Government http://www.scotland.gov.uk/Topics/Health/Services/Prev enting-Healthcare-Infections/Infection- Monitoring/Taskforce

CDI REFERENCES 150 Clinical Practice Guidelines for Clostridium difficile Infect Cont Hoso Cohen SH et al http://www.idsociety.org/Organism/ Infection in Adults: 2010 Epidem 2010 ; 31 : 431 -455 186 Successful use of feedback to improve antibiotic JAC (2007) 59 (5): Fowler S et al http://jac.oxfordjournals.org/content/59/5/990.full prescribing and reduce Clostridium difficile infection: a 990-995. controlled interrupted time series 439 Updated guidance on the management and treatment HPA HPA www.hpa.org.uk/webc/HPAwebfile/HPAweb_C/1317138 of Clostridium difficile infection (English Guidance) 914904

SABs MRSA REFERENCES 166 Management of Patients with Infections Caused by Clinical Infectious LIU C et al http://www.idsociety.org/Organism/ Methicillin-Resistant Staphylococcus Aureus Diseases ; 2011 ; 52 : 1 -38 205 Guidelines for UK practice for the diagnosis and J. Antimicrob. Nathwani D et al http://jac.oxfordjournals.org/content/61/5/976.full.pdf management of (MRSA) infections presenting in the Chemother.,2008; community 61: 976 - 994. 392 Clinical Management of SAB (via TKN / Athens login) Lancet Inf Dis Thwaites GE et http://www.thelancet.com/journals/laninf/article/PIIS147 19 Element 4 - HEALTHCARE ASSOCIATED INFECTION (HAI) - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments 2011;11:208-22 al 3-3099(10)70285-1/abstract 368 MRSA Screening and Suppression - Quick Reference HPA http://www.hpa.org.uk/Topics/InfectiousDiseases/Infecti Guide for Primary Care onsAZ/PrimaryCareGuidance/

20 Resources for Element 5 Sepsis Diagnosis and Management CORE RESOURCES Element 5 - SEPSIS - CORE RESOURCES Presenter Date Resource Resource Accessed/ Comments ID Name of resource Resource owner /Author URL link direct to resource GENERAL SEPSIS REFERENCES 84 Neutropenic Sepsis CG151 2012 NICE NICE http://publications.nice.org.uk/neutropenic-sepsis- prevention-and-management-of-neutropenic-sepsis-in- cancer-patients-cg151 272 Sepsis - Improving care, improving outcome (via TKN) ASAP Shared Space Rooney K http://www.elib.scot.nhs.uk/SharedSpace/pharmacy/U (30 mins) ploads/2012/Mar/20120307120621_ASAP %20presentation%20Kevin%20Rooney.pdf 334 Diagnosis and Treatment of Sepsis for ASAP (45 mins) NES Dilip Nathwani http://www.nes.scot.nhs.uk/education-and-training/by- discipline/pharmacy/about-nes-pharmacy/educational- resources/resources-by-topic/infectious- diseases/infection/diagnosis-and-treatment-of-sepsis- for-asap.aspx 381 NHS Scotland NEWS & Sepsis Screening Tool iTunes NES https://itunes.apple.com/gb/app/nhs-scotland-news- sepsis-screening/id657497806?mt=8 435 Antibiotic Use within Intensive Care (34 mins) NES Radha Sundaram http://vimeo.com/79978740

SEPSIS-INDUCED ORGAN DYSFUNCTION REFERENCES 279 Mechanisms of Sepsis -Induced Organ Dysfunction (via Critical Care Abraham E et al http://www.knowledge.scot.nhs.uk/home/search- TKN / Athens login) Medicine results.aspx?q=publicid:%22ebscocinahl| 2007;35(10):2408-16 2009738199%22&pm=fql&expand=true&portal=

21 SUPPLEMENTARY RESOURCES Element 5 - SEPSIS - SUPPLEMENTARY RESOURCES Presenter/Auth Date Resource Resource Accessed/ Comments ID Name of resource Resource owner or URL link direct to resource GENERAL SEPSIS REFERENCES 149 2012 International Guidelines for Management of Critical Care Dellinger PR http://www.idsociety.org/Organ_System/ Severe Sepsis and Septic Shock Medicine ; 2013 ; 41 : 580 -637 213 The sepsis six and the severe sepsis resuscitation Emerg Med J Daniels R et al http://emj.bmj.com/search? bundle: a prospective observational cohort study (via 2011;28:6 507-512 submit=yes&pubdate_year=&volume=&firstpage=&doi= TKN / Athens login) &author1=Daniels+R&author2=Nutbeam+T&title=sepsis &andorexacttitle=and&titleabstract=&andorexacttitleab s=and&fulltext=&andorexactfulltext=and&resourcetype =HWCIT&fmonth=&fyear=2010&tm 301 ABC of Sepsis 2010 if available BMJ Books wiley Daniels R Blackwell 309 Septic Shock Clinical Vignette (02) (free registration for PAUSE BSAC http://www.pause-online.org.uk HCPs) (2 hours) 380 Severe sepsis and septic shock NEJM Derek C et al http://www.nejm.org/doi/full/10.1056/NEJMra1208623 382 Critical Care & Trauma Part 8: Surgical Sepsis Office of Jackson A et al http://ptolemy.library.utoronto.ca/content/critical-care- International Surgery, and-trauma-part-8-surgical-sepsis U. Toronto

SEPSIS BIOMARKERS REFERENCES 280 Molecular diagnostics of sepsis where are we today? Int J Med Microbiol Bauer M et al http://www.sciencedirect.com/science/article/pii/S1438 (via TKN / Athens login) 2010;300(6):411-3 422110000317 281 Use of procalcitonin to reduce patients' exposure to Lancet Bouadma L et al http://www.sciencedirect.com/science/article/pii/S0140 antibiotics in intensive care units (PRORATA trial):(via 2010;375(9713):463- 673609618791 TKN / Athens login) 74 370 Procalcitonin - what does it mean for sepsis (YouTube) BC Patient Safety & Reynolds S http://www.youtube.com/watch?v=ie0QpnRCfbs (46 mins) Quality Council

22 Element 5 - SEPSIS - SUPPLEMENTARY RESOURCES Presenter/Auth Date Resource Resource Accessed/ Comments ID Name of resource Resource owner or URL link direct to resource 371 Novel biomarkers for infection & sepsis 2010 (30 mins) BSAC Dark P http://bsac.org.uk/PlayVideoPage.html?url=https://s3- eu-west-1.amazonaws.com/havap-2010/08_Paul_Dark

23 Resources for element 6 Acute respiratory tract infection incorporating pneumonia and COPD CORE RESOURCES Element 6 - ACUTE RRESPIRATORY TRACT INFECTION - CORE RESOURCES Presenter Date Resource Resource Accessed/ Comments ID Name of resource Resource owner /Author URL link direct to resource GENERAL RESPIRATORY REFERENCES 9 Antibiotic Prescribing for Today's Practitioner (2 hours) NES NES/LearnPro http://www.nes.scot.nhs.uk/education-and-training/by- theme-initiative/healthcare-associated- infections/online-short-courses/antibiotic- prescribing.aspx

PNEUMONIA & INFLUENZA REFERENCES 90 Pneumonia CG DRAFT NICE NICE http://guidance.nice.org.uk/index.jsp?action=find 122 Community Acquired Pneumonia Care Bundle SAPG http://www.scottishmedicines.org.uk/files/sapg/Comm unity_Acquired_Pneumonia_Care_Bundle-DRAFTv0.pdf 193 BTS Guideline on Management of Community Thorax 2009;64(3) Lim WS et al http://www.brit-thoracic.org.uk/guidelines-and-quality- Acquired Pneumonia in Adults (2009) standards/community-acquired-pneumonia-in-adults- guideline/ 204 Guidelines for the management of hospital-acquired J. Antimicrob. Masterton RG http://jac.oxfordjournals.org/content/62/1/5.full.pdf+ht pneumonia in the UK: Report of the Working Party of Chemother., July ml?sid=490c8455-ddc9-4139-8069-a5ded90e4e7b BSAC 2008; 62: 5 - 34 409 HPA guidance on use of antiviral agents for the HPA http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/ treatment and prophylaxis of influenza (Oct 2012) 1317131466016

OTHER ACUTE LRTI REFERENCES 201 Chronic obstructive pulmonary disease NICE CG101 NICE http://guidance.nice.org.uk/CG101 262 GOLD Initiative for Chronic Obstructive Lung Disease GOLD http://www.goldcopd.org/guidelines-resources.html 2013 265 Atypical Infection? Respiratory Case Study (via TKN) ASAP Shared Space Sneddon J http://www.elib.scot.nhs.uk/SharedSpace/pharmacy/U ploads/2013/Mar/20130326101614_Atypical%20Case %20Study%20Resp.pdf 24 Element 6 - ACUTE RRESPIRATORY TRACT INFECTION - CORE RESOURCES Presenter Date Resource Resource Accessed/ Comments ID Name of resource Resource owner /Author URL link direct to resource

UPPER RESPIRATORY TRACT INFECTION REFERENCES 88 Respiratory Tract Infections in primary care CG69 NICE NICE http://publications.nice.org.uk/respiratory-tract- infections-antibiotic-prescribing-cg69

SUPPLEMENTARY RESOURCES Element 6 - ACUTE RESPIRATORY TRACT INFECTION - SUPPLEMENTARY RESOURCES

Presenter/Auth Date Resource Resource ID Name of resource Resource owner or URL link direct to resource Accessed/ Comments PNEUMONIA & INFLUENZA REFERENCES 14 Preventing Ventillator Associated Pneumonia (60 NES LearnPro http://www.nes.scot.nhs.uk/education-and-training/by- mins) theme-initiative/healthcare-associated- infections/online-short-courses/preventing-ventilator- associated-pneumonia.aspx 183 Seasonal Influenza in Adults and Children— Clin Infect Dis 2009 ; Harper SA http://www.idsociety.org/Organism/ Diagnosis, Treatment, Chemoprophylaxis, and 48 : 1003 -1032 Institutional Outbreak Management: Clinical Practice Guidelines 195 British Thoracic Society guidelines for the Thorax 2011;66 (2) Harris M et al http://www.brit-thoracic.org.uk/guidelines-and-quality- management of community acquired pneumonia in standards/community-acquired-pneumonia-in-children- children: update 2011 guideline/ 200 Guidelines for the clinical management of patients Thorax 2007;62;1-46 Lim WS http://www.brit-thoracic.org.uk/guidelines-and-quality- with an influenza-like illness during an influenza standards/influenza/ pandemic 224 Ventilator associated pneumonia (via TKN / Athens BMJ 2012;334e3325 Hunter JD http://www.bmj.com/content/344/bmj.e3325 login) 308 Pneumonia Clinical Vignette (01) (free registration PAUSE BSAC http://www.pause-online.org.uk 25 Element 6 - ACUTE RESPIRATORY TRACT INFECTION - SUPPLEMENTARY RESOURCES

Presenter/Auth Date Resource Resource ID Name of resource Resource owner or URL link direct to resource Accessed/ Comments for HCPs) (2 hours) 482 Analysis Relationships Between Pharmacokinetic Adv Clin Exp Med Grabowski T et http://www.advances.am.wroc.pl/pdf/2008/17/3/285.p Parameters in silico/in vivo of Selected Antiviral 2008, 17, 3, 285–292 al df Drugs Based on Structural Analysis

URTI REFERENCES 38 Management of Sore Throat and Indication for SIGN SIGN http://www.sign.ac.uk/guidelines/fulltext/117/index.ht Tonsillectomy (2010) SIGN 117 ml 160 IDSA Clinical Practice Guideline for Acute Bacterial Clinical Infectious Chow AW et al http://www.idsociety.org/Organ_System/#Lower/Upper Rhinosinusitis in Children and Adults"US Update on Diseases ; 2012 ; : e1 Respiratory NICE CG 69 -e41 161 Clinical Practice Guideline for the Diagnosis and Clinical Infectious Shulman ST http://www.idsociety.org/Organ_System/#Lower/Upper Management of Group A Streptococcal Pharyngitis: Diseases ; 2012 ; : 1 Respiratory 2012 ( more recent than SIGN 117) -17 263 Antibiotics for sore throat (via TKN / Athens login) CDSR 2006(4) Art No Spinks A http://onlinelibrary.wiley.com/doi/10.1002/14651858.C CD000023 D000023.pub3/abstract;jsessionid=2E5B87CAD4DC6091 A291B972C7D4889F.d01t04 322 Sore Throat Clinical Vignette (15) (free registration PAUSE BSAC http://www.pause-online.org.uk for HCPs) (90 mins)

26 Resources for element 7 - Urinary tract infection (UTI) CORE RESOURCES Element 7 - URINARY TRACT INFECTION (UTI) - CORE RESOURCES

Resource Presenter Date Resource ID Name of resource Resource owner /Author URL link direct to resource Accessed/ Comments GENERAL UTI REFERENCES Local Antimicrobial Guidelines 9 Antibiotic Prescribing for Today's Practitioner NES NES/LearnPro http://www.nes.scot.nhs.uk/education-and-training/by- (cases 3 & 7) theme-initiative/healthcare-associated-infections/online- short-courses/antibiotic-prescribing.aspx 43 Management of Suspected Bacterial Urinary Tract SIGN http://www.sign.ac.uk/guidelines/fulltext/88/index.html Infections in Adults (updated 2012) SIGN 88 74 Urinary Tract Infection in Children CG54 NICE NICE http://publications.nice.org.uk/urinary-tract-infection-in- children-cg54 108 Decisions Aid for Diagnosis and Management of SAPG SAPG http://www.scottishmedicines.org.uk/files/sapg/SAPG_D Suspected UTI in Older People ecision_aid_for_UTI_in_older_people_-_May_2013.pdf 253 European Association of Urology Guidelines on EAU Grabe M et al http://www.uroweb.org/gls/pdf/18_Urological Urological Infections 2013 (Use in conjunction with %20infections_LR.pdf local antibiotic prescribing guidelines)

PYELONEPHRITIS REFERENCES 156 Guidelines for Antimicrobial Treatment of Acute Clin Infect Dis 2011 ; Gupta K et al http://www.idsociety.org/Organ_System/#Genitourinary Uncomplicated Cystitis and Pyelonephritis in Women 52 : e103 -e120 (refer to local prescribing guidelines) 299 Reese & Betts' practical approach to infectious Lippincott Williams Betts RF et al http://www.knowledge.scot.nhs.uk/home/library/books/ diseases 5th Ed 2003 (on TKN) or alternative and Wilkins books- available text book for background information (UTI/pyelonephritis Chapter used in conjunction with local guidelines for specific antibiotics)

27 Element 7 - URINARY TRACT INFECTION (UTI) - CORE RESOURCES

Resource Presenter Date Resource ID Name of resource Resource owner /Author URL link direct to resource Accessed/ Comments CAUTI REFERENCES 155 Diagnosis, Prevention, and Treatment of Catheter- Clin Infect Dis 2010 ; Hooton TM http://www.idsociety.org/Organ_System/#Genitourinary Associated Urinary Tract Infection in Adults: 2009 50 : 625 -663

SUPPLEMENTARY RESOURCES Element 7 - URINARY TRACT INFECTION - SUPPLEMENTARY RESOURCES

Resource Presenter Date Resource ID Name of resource Resource owner /Author URL link direct to resource Accessed/ Comments GENERAL UTI REFERENCES 154 Guidelines for the Diagnosis and Treatment of Clin Infect Dis 2005 ; Nicolle LE http://www.idsociety.org/Organ_System/#Genitourinary Asymptomatic Bacteriuria in Adults 40 : 643 -654 225 Presentation, pattern, and natural course of severe BMJ 2010;340:b5633 Little P et al http://www.bmj.com/content/340/bmj.b5633? symptoms, and role of antibiotics and antibiotic view=long&pmid=20139213 resistance among patients presenting with suspected uncomplicated urinary tract infection in primary care: observational study. (via TKN / Athens login) 313 UTI in Pregnancy Clinical Vignette(06) NB refer to PAUSE BSAC http://www.pause-online.org.uk local policy for choice of antibiotic regimens (free registration for HCPs) (90 mins)

PYELONEPHRITIS REFERENCES 312 UTI Pyelonephritis Clinical Vignette(05) NB drug PAUSE BSAC http://www.pause-online.org.uk regimens differ from latest guidance (free registration for HCPs) (2 hours) 315 Pyelonephritis Clinical Vignette (08) NB drug PAUSE BSAC http://www.pause-online.org.uk regimens differ from latest guidance (free registration for HCPs) (2 hours)

28 Element 7 - URINARY TRACT INFECTION - SUPPLEMENTARY RESOURCES

Resource Presenter Date Resource ID Name of resource Resource owner /Author URL link direct to resource Accessed/ Comments

CAUTI REFERENCES 316 Catheter Associated Infection Clinical Vignette(09 ) PAUSE BSAC http://www.pause-online.org.uk (free registration for HCPs) (90 mins)

29 Resources for Element 8 Skin and soft tissue infection (SSTI) CORE RESOURCES Element 8 - SKIN AND SOFT TISSUE INFECTION (SSTI) - CORE RESOURCES

Resource Presenter Date Resource ID Name of resource Resource owner /Author URL link direct to resource Accessed/ Comments GENERAL SSTI REFERENCES 165 Practice Guidelines for the Diagnosis and Clin Infect Dis 2005 ; Stevens DL et al http://www.idsociety.org/Organ_System/#Skin & Soft Management of Skin and Soft Tissue Infections 41 : 1373 -1406 Tissue 434 Treating infections in Skin & Soft Tissue in acute and NES Andrew Seaton http://vimeo.com/79984822 OPAT settings (60 mins)

CELLULITIS & VENOUS LEG ULCER REFERENCES 216 Diagnosis and management of cellulitis (via TKN / BMJ 2012; 345:e4955 Phoenix G http://www.bmj.com/content/345/bmj.e4955 Athens login) 310 Cellulitis Clinical Vignette (03) (free registration for PAUSE BSAC http://www.pause-online.org.uk HCPs) (90 mins) 369 Venous Leg Ulcers: Infection Diagnosis & HPA http://www.hpa.org.uk/Topics/InfectiousDiseases/Infecti Microbiology Investigation onsAZ/PrimaryCareGuidance/

NECROTISING FASCIITIS AND OTHER SERIOUS SSTI REFERENCES 227 Necrotising Fasciitis (via TKN / Athens login) BMJ 2005;330:830 Hasham S et al http://www.bmj.com/content/330/7495/830 256 Lyme Borreliosis (via TKN / Athens login) Lancet 379 Feb Stanek G et al http://www.sciencedirect.com/science/article/pii/S01406 2012(9814);461-76 73611601037

DIABETIC FOOT ULCER REFERENCES 116 Use of antibiotics in people with diabetic foot disease The Diabetic Foot Leese G et al http://www.scottishmedicines.org.uk/files/sapg/Use_of_ - a consensus statement Journal Vol 12 No 2 Antibiotics_in_people_with_diabetic_foot_disease_- 2009 _Consensus_Statement_-_2009.pdf

30 Element 8 - SKIN AND SOFT TISSUE INFECTION (SSTI) - CORE RESOURCES

Resource Presenter Date Resource ID Name of resource Resource owner /Author URL link direct to resource Accessed/ Comments 320 Foot Infection in Diabetic Ulcer Clinical Vignette (13) PAUSE BSAC http://www.pause-online.org.uk (free registration for HCPs) (90 mins)

MRSA & PVL-SA REFERENCES 282 Guidance on the diagnosis and management of PVL- HPA Public Health http://www.hpa.org.uk/Publications/InfectiousDiseases/I associated staphylococcus aureus infections (PLL-SA) England nfectionControl/0811Guidanceonthediagnosisandmanage in England (Awaiting Scottish Document in 2014) mentofPVLSA/ 203 Guidelines (2008) for the prophylaxis and treatment J. Antimicrob. Gould FK et al http://jac.oxfordjournals.org/content/63/5/849.full.pdf of methicillin-resistant Staphylococcus aureus (MRSA) Chemother., May infections in the United Kingdom 2009; 63: 849 - 861

SUPPLEMENTARY RESOURCES Element 8 - SKIN AND SOFT TISSUE INFECTION (SSTI) - SUPPLEMENTARY RESOURCES

Resource Presenter Date Resource ID Name of resource Resource owner /Author URL link direct to resource Accessed/ Comments GENERAL SSTI REFERENCES 228 Skin and soft tissue infection diagnosis and Clinical Pharmacist Seaton RA http://www.pjonline.com/search/all? management (Registration required with RPS - fee) 2009;1:13-22 filter0=skin+and+soft+tissue+infection+diagnosis+and+ma nagement&filter8=&filter7%5BClinical+Pharmacist %5D=Clinical+Pharmacist&filter4=2009&filter5=&filter6= &filter2=**ALL**&filter1=**ALL**&x=12&y=11

CELLULITIS & VENOUS LEG ULCER REFERENCES 226 Antibiotics and antiseptics for venous leg ulcers (via Cochrane Database O'Meara S et al http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD TKN / Athens login) Syst Rev. 2010; 003557.pub3/abstract;jsessionid=A03FE67A45BF8EF9897 (1):CD003557. 382C8CBB6292C.d03t03 31 Element 8 - SKIN AND SOFT TISSUE INFECTION (SSTI) - SUPPLEMENTARY RESOURCES

Resource Presenter Date Resource ID Name of resource Resource owner /Author URL link direct to resource Accessed/ Comments NECROTISING FASCIITIS AND OTHER SERIOUS SSTI REFERENCES 167 The Clinical Assessment, Treatment, and Prevention Clin Infect Dis 2006 ; Wormser GP et http://www.idsociety.org/Organism/ of Lyme Disease, Human Granulocytic Anaplasmosis, 43 : 1089 -1134 al and Babesiosis

DIABETIC FOOT ULCER REFERENCES 92 Diabetic Foot Problems CG119 NICE NICE http://publications.nice.org.uk/diabetic-foot-problems- cg119 164 Diagnosis and Treatment of Diabetic Foot Infections Clin Infect Dis 2012 ; Lipsky BA http://www.idsociety.org/Organ_System/#Skin & Soft 54 : e132 -e173 Tissue

MRSA & PVL-SA REFERENCES 166 Management of Patients with Infections Caused by Clinical Infectious LIU C et al http://www.idsociety.org/Organ_System/#Skin & Soft Methicillin-Resistant Staphylococcus Aureus Diseases ; 2011 ; 52 : Tissue 1 -38 205 Guidelines for UK practice for the diagnosis and J. Antimicrob. Nathwani D et al http://jac.oxfordjournals.org/content/61/5/976.full.pdf management of (MRSA) infections presenting in the Chemother.,2008; community 61: 976 - 994. 229 Skin and soft tissue infection focus on MRSA Clinical Pharmacist Seaton RA http://www.pjonline.com/search/all? (Registration required with RPS - fee) 2009;1:23-28 filter0=skin+and+soft+tissue+infection+diagnosis+and+ma nagement&filter8=&filter7%5BClinical+Pharmacist %5D=Clinical+Pharmacist&filter4=2009&filter5=&filter6= &filter2=**ALL**&filter1=**ALL**&x=12&y=11

OTHER SSTI REFERENCES 364 Acne Vulgaris (30 mins) NICE CKS http://cks.nice.org.uk/acne-vulgaris 366 Atopic eczema in children: Management of atopic NICE http://publications.nice.org.uk/atopic-eczema-in- 32 Element 8 - SKIN AND SOFT TISSUE INFECTION (SSTI) - SUPPLEMENTARY RESOURCES

Resource Presenter Date Resource ID Name of resource Resource owner /Author URL link direct to resource Accessed/ Comments eczema in children from birth up to the age of 12 children-cg57 years 367 Fungal Skin and Nail Infections Primary Care Quick HPA http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/12 Reference Guide 40294785726 431 NICE CKS Guidelines on Fungal nail & skin infections NICE NICE http://cks.nice.org.uk/

33 Resources for Element 9 Surgical infection & prophylaxis CORE RESOURCES Element 9 - SURGICAL INFECTION AND PROPHYLAXIS -CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL SURGICAL INFECTION & PROPHYLAXIS REFERENCES (also covering MRSA) 41 Antibiotic Prophylaxis in Surgery (2008) SIGN 104 SIGN http://www.sign.ac.uk/guidelines/fulltext/104/index.html 87 Surgical Site Infection CG74 NICE NICE http://publications.nice.org.uk/surgical-site-infection-cg74 119 SAPG Good Practice Recommendations for Surgical SAPG SAPG http://www.scottishmedicines.org.uk/files/sapg/Good_pra and Procedural Antibiotic Prophylaxis 2012 ctice_recommendations_for_surgical_prophylaxis_2012.pd f 139 Clinical practice guidelines for antimicrobial Am J Health Syst Bratzler DW et al http://www.idsociety.org/Antimicrobial_Agents/#Antimicr prophylaxis in surgery Pharm 2013; 70: 195- obial Prophylaxis for Surgery 283

ASPLENIA & VALVULAR HEART DISEASE REFERENCES 232 Review of guidelines for the prevention and treatment British Journal of Davies JM et al http://www.sbp.com.br/pdfs/Review_guidelinesfortheprev of infection in patients with an absent or dysfunctional Haematology 2011, entionandtreatmentofinfectioninpatientswithaabsentordys spleen 155, 308–317 functionalsp.pdf 89 NICE Prophylaxis Against Infective Endocarditis CG64 NICE NICE http://publications.nice.org.uk/prophylaxis-against- infective-endocarditis-cg64

TRAUMA REFERENCES 470 The Management of Severe Open Lower Limb BRITISH http://www.boa.ac.uk/LIB/LIBPUB/Documents/BOAST Fractures (BOAST 4) 2009 ORTHOPAEDIC %204%20-%20The%20Management%20of%20Severe ASSOCIATION & %20Open%20Lower%20Limb%20Fractures.pdf BAPRAS

34 SUPPLEMENTARY RESOURCES Element 9 - SURGICAL INFECTION AND PROPHYLAXIS - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL SURGICAL INFECTION & PROPHYLAXIS REFERENCES 9 Antibiotic Prescribing for Today's Practitioner (2 NES NES/LearnPro http://www.nes.scot.nhs.uk/education-and-training/by- hours) theme-initiative/healthcare-associated-infections/online- short-courses/antibiotic-prescribing.aspx 58 Surgical Prophylaxis for gram positive and gram BSAC Mark Willox http://www.online-web- negative infections (30 mins) presentations.com/SSI/day1/pdf/Mark%20Wilcox.pdf 339 SAPG Guidance on Re-Dosing Antimicrobials for SAPG J Sneddon A Surgical Prophylaxis MacDonald 233 Infections associated with orthopedic implants (via Curr Op Infect Dis Trampuz A et al http://www.knowledge.scot.nhs.uk/home/search- TKN / Athens login) 2006;19:349-356 results.aspx?q=publicid:%22OVIDemed7| 16804382%22&pm=fql&expand=true&portal= 382 Critical Care & Trauma Part 8: Surgical Sepsis Office of Jackson A et al http://ptolemy.library.utoronto.ca/content/critical-care- International Surgery, and-trauma-part-8-surgical-sepsis U. Toronto 476 Surgical Site Infection Surveillance HPS http://www.hps.scot.nhs.uk/haiic/sshaip/surgicalsiteinfecti onsurveillance.aspx 493 NICE Quality Standard QS49 Surgical site infection NICE NICE http://publications.nice.org.uk/surgical-site-infection-qs49

35 Resources for Element 10 Pharmacokinetics (PK) pharmacodynamics (PD) and therapeutic drug monitoring (TDM) CORE RESOURCES Element 10 - ANTIMICROBIAL PHARMACOKINETICS (PK), PHARMACODYNAMICS (PD) & THERAPEUTIC DRUG MONITORING (TDM) - CORE RESOURCES Date Resource Resource Presenter/Auth Accessed/ ID Name of resource Resource owner or URL link direct to resource Comments GENERAL PK, PD AND TDM REFERENCES 103 Therapeutic Drug Monitoring of Antimicrobials via Br J Pharmacol Roberts JA et al http://onlinelibrary.wiley.com.proxy.knowledgeservices.or TKN / Athens login) g/doi/10.1111/j.1365-2125.2011.04080.x/pdf 143 Vancomycin Therapeutic Monitoring: Review and Am J Health-Syst Rybak M et al http://www.idsociety.org/Antimicrobial_Agents/ Recommendations from the ASHP, IDSA and SIDP Pharm ; 2009 ; 66 : 82 Task Force -98 468 Pharmacokinetics Webinar General (20 mins?) NES Alison Thomson Awaiting link 509 Pharmacokinetics in specialist groups (20 mins?) NES Alison Thomson Awaiting link still to be recorded 189 Development of teicoplanin dosage guidelines for JAC (2009) 64 (1): Lamont E et al http://jac.oxfordjournals.org/content/64/1/181.full patients treated within an (OPAT) programme 181-187. 273 Development of gentamicin guidelines for synergistic ASAP Shared Space Thomson A http://www.elib.scot.nhs.uk/SharedSpace/pharmacy/Uploa use (via TKN) ds/2011/Mar/20110323151742_Gent-dosing_synergy.pdf 335 Antibiotic pharmacokinetic and pharmacodynamic NES Andrew Lovering http://www.nes.scot.nhs.uk/education-and-training/by- indices : for ASAP (1 hour and 40 mins) discipline/pharmacy/about-nes-pharmacy/educational- resources/resources-by-topic/infectious- diseases/antibiotics/antibiotic-pharmacokinetic-and- pharmacodynamic-indices-for-asap.aspx 383 Pharmacodynamics of antibiotics : focus on outcome NES Andrew Lovering http://www.nes.scot.nhs.uk/education-and-training/by- & resistance : for ASAP (60 mins) discipline/pharmacy/about-nes-pharmacy/educational- resources/resources-by-topic/infectious- diseases/antibiotics/pharmacodynamics-of-antibiotics- focus-on-outcome-resistance-for-asap.aspx 59 The impact of recent antimicrobial interventions - the BSAC William Hope http://www.online-web- PK/PD debate & what the evidence says 30 mins) presentations.com/BSAC_HAVAP2010/

AMINOGLYCOSIDE & GLYCOPEPTIDE REFERENCES 36 Element 10 - ANTIMICROBIAL PHARMACOKINETICS (PK), PHARMACODYNAMICS (PD) & THERAPEUTIC DRUG MONITORING (TDM) - CORE RESOURCES Date Resource Resource Presenter/Auth Accessed/ ID Name of resource Resource owner or URL link direct to resource Comments 338 Gentamicin and Vancomycin Training Resource (4 NES/LearnPro Alison Thomson http://www.nes.scot.nhs.uk/education-and-training/by- hours) theme-initiative/healthcare-associated-infections/online- short-courses/gav-gentamicin-and-vancomycin.aspx 395 SAPG Intravenous gentamicin (GG&C and Hartford) & SAPG SAPG http://www.scottishmedicines.org.uk/SAPG/Quality_Impro Vancomycin (Continuous & pulsed) vement/Gentamicin_and_Vancomycin

SUPPLEMENTARY RESOURCES Element 10 - ANTIMICROBIAL PHARMACOKINETICS (PK), PHARMACODYNAMICS (PD) & THERAPEUTIC DRUG MONITORING (TDM) - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL PK, PD AND TDM REFERENCES 396 Examples of dosage regimen design (registration The Pharmaceutical Thomson AH http://www.pjonline.com/cpd/examples_of_dosage_regim required with RPS - fee) Journal2004;273:188 en_design 397 Why do therapeutic drug monitoring (registration The Pharmaceutical Thomson AH http://www.pjonline.com/cpd/why_do_therapeutic_drug_ required with RPS - fee) Journal2004;273:153 monitoring 398 Variability in drug dosage requirements (registration The Pharmaceutical Thomson AH http://www.pjonline.com/cpd/variability_in_drug_dosage_ required with RPS - fee) Journal2004;272:806 requirements 399 Back to basics: pharmacokinetics (registration The Pharmaceutical Thomson AH http://www.pjonline.com/cpd/back_to_basics_pharmacoki required with RPS - fee) Journal2004;272:769 netics 400 Bespoke pharmacy: Tailoring medicines to the needs Hospital Thomson AH http://www.pjonline.com/cpd/bespoke_pharmacy_tailorin of patients - the role of therapeutic drug monitoring Pharmacist2003;10:1 g_medicines_to_the_needs_of_patients_the_role_of_ther (registration required with RPS - fee) 60 apeutic_drug_monit 235 Continuous v intermittent infusions of antibiotics for Cochrane Database Shiu J et al http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD0 the treatment of severe acute infections (via TKN / Syst Rev 2013(3) Art 08481.pub2/abstract Athens login) No CD008481

37 Element 10 - ANTIMICROBIAL PHARMACOKINETICS (PK), PHARMACODYNAMICS (PD) & THERAPEUTIC DRUG MONITORING (TDM) - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments PK IN SPECIAL PATIENT GROUPS REFERENCES 457 Clinical pharmacokinetics of vancomycin in the Clinics (Sao Paulo). Pacifici GM http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400177/ neonate: a review 2012 July; 67(7): Allegaert K 831–837 441 UKCPA Drug Dosing in Extremes of Body Weight in UKCPA Link to PDF on NES website Critically Ill Patients 2013 455 Antibiotic Use in Pregnancy and Lactation OBSTETRICS & Nahum GG et al http://www.amchp.org/programsandtopics/womens- GYNECOLOGY 2006; health/CDC/ANTIBIOTICS/Nahum.pdf 107(5): 1120-38 502 How should antibiotics be dosed in obesity? UKMI NICE Evidence UKMI https://www.evidence.nhs.uk/topic/obesity?om=%5B%7B Q&A 378.1 %22srn%22%3A%5B%22%20ukmi%20%22%5D%7D%5D 100 Dosing of Antibiotics in Obesity (via TKN / Athens Current Opinion in Janson B, http://www.knowledge.scot.nhs.uk/home/search- login) Infectious Diseases Thursky K results.aspx?q=publicid:"OVIDmedl| 23041773"&pm=fql&expand=true&portal= 456 Clinical Pharmacokinetics of Penicillins, Pharmaceuticals Pacifici, G.M http://www.mdpi.com/1424-8247/3/8/2568 Cephalosporins and Aminoglycosides in the Neonate 2010; 3 (8): 2568- 2591. 483 The Role of Therapeutic Drug Monitoring in the Therapeutic Drug Pretorius E et al http://ovidsp.uk.ovid.com/sp-3.10.0b/ovidweb.cgi? Management of Patients With Human Monitoring. 33 &S=GLBKPDMHJPHFPDOIFNNKLGOFIPCIAA00&Complete+R Immunodeficiency Virus Infection (via TKN / Athens (3):265-74 2011 eference=S.sh.61%7c1%7c1 login)

237 Antibiotic dosing in critical illness J Antimicrob MacKenzie C et http://jac.oxfordjournals.org/content/66/suppl_2/ii25.long Chemother 2011;66 al S2ii23-ii31

PK, PD & TDM WITH OTHER DRUG GROUPS 503 Therapeutic drug monitoring (TDM) of antifungal J Antimicrob Ashbee HR et al http://jac.oxfordjournals.org/content/early/2013/12/28/ja 38 Element 10 - ANTIMICROBIAL PHARMACOKINETICS (PK), PHARMACODYNAMICS (PD) & THERAPEUTIC DRUG MONITORING (TDM) - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments agents: guidelines from the British Society for Chemother (2013) c.dkt508.full?hwoaspck=true&sid=94fb36c1-9153-44c8- Medical Mycology doi: b5a5-bddaddddb708 10.1093/jac/dkt508 480 Optimizing antifungal choice and administration (via Curr Med Research Andes D http://informahealthcare.com.proxy.knowledgeservices.or TKN / Athens login) Opin. 29, Sup 4, g/doi/pdf/10.1185/03007995.2012.761135 2013, 13–18 481 Sequential treatment of cytomegalovirus infection or Transpl Infect Dis Caldes A et al http://web.ebscohost.com/ehost/pdfviewer/pdfviewer? disease with a short course of intravenous ganciclovir 2010: 12: 204-212 sid=24958c00-b045-48e3-8eeb-65821613812b followed by oral valganciclovir: efficacy. safety, and %40sessionmgr110&vid=2&hid=123 pharmacokinetics (via TKN / Athens login) 482 Analysis Relationships Between Pharmacokinetic Adv Clin Exp Med Grabowski T et http://www.advances.am.wroc.pl/pdf/2008/17/3/285.pdf Parameters in silico/in vivo of Selected Antiviral 2008, 17, 3, 285–292 al Drugs Based on Structural Analysis

39 Resources for Element 11 Data analysis and presentation Incorporating interpretation of audit data CORE RESOURCES Element 11 - DATA ANALYSIS AND PRESENTATION INCORPORATING INTERPRETATION OF AUDIT DATA - CORE RESOURCES Date Resource Resource Accessed/ Resource ID Name of resource owner Presenter/Author URL link direct to resource Comments 446 Introduction to routine data for ASAP (16 NES Vicky Elliott https://attendee.gotowebinar.com/recording/7181743125700807938 mins) 472 Basic statistics for ASAP (17 mins) NES Vicky Elliott https://attendee.gotowebinar.com/recording/6376940196590164993 473 Data for quality improvement for ASAP NES Andrea Patton https://attendee.gotowebinar.com/recording/4826215385075476226 (14 mins) 474 Utilising and presenting data from NES Vicky Elliott https://attendee.gotowebinar.com/recording/6282428376111341058 routine sources for ASAP (18 mins) 475 Statistical Process Control (SPC) for ASAP NES Gwen Bayne Awaiting link to NES Educational materials on website – still to be (20 mins) recorded 507 Sixth Data Analysis Presentation for NES Gwen Bayne Still to be recorded ASAP (20 mins) 508 The Power of Local Data for ASAP (20 NES Frances Kerr? Still to be recorded mins) 494 Surgical Prophylaxis Indicator Report SAPG http://www.scottishmedicines.org.uk/files/sapg/Surgical_ Prophylaxis_Indicator_Report_October_2013.pdf 495 National Services Scotland Annual NHS National http://www.nhsnss.org/pages/publications/annual_reports.php Report Services Scotland

SUPPLEMENTARY RESOURCES Element 11 - DATA ANALYSIS AND PRESENTATION INCORPORATING INTERPRETATION OF AUDIT DATA - SUPPLEMENTARY RESOURCE Date Resource Presenter Accessed/ Resource ID Name of resource Resource owner /Author URL link direct to resource Comments 7 Patterns of Antimicrobial Use and Resistance in NES William Malcolm http://www.video3uk.com/login.aspx

40 Element 11 - DATA ANALYSIS AND PRESENTATION INCORPORATING INTERPRETATION OF AUDIT DATA - SUPPLEMENTARY RESOURCE Date Resource Presenter Accessed/ Resource ID Name of resource Resource owner /Author URL link direct to resource Comments Scotland(MSc) (56 mins) 53 Antimicrobial resistance surveillance, improving BSAC Prof Alasdair http://bsac.org.uk/events/past-events-2011/spring- relevance and outputs 20 mins) McGowan meeting-agm-2011/spring-meeting-2011/ 109 From intermittent antibiotic point prevalence Antimicrob Res Inf Malcolm W et al http://www.aricjournal.com/content/2/1/3 surveys to quality improvement: experience in Cont 2013;2:3 Scottish hospitals 447 Excel 2007 training course Microsoft office http://office.microsoft.com/en-us/training/excel-2007- training-courses-HA010218987.aspx? CTT=5&origin=HA010225533

41 Resources for Element 12 Meningitis and CNS Infection CORE RESOURCES Element 12 - MENINGITIS AND CNS INFECTION - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments MENINGITIS REFERENCES 35 Management of Invasive Meningococcal Disease in SIGN http://www.sign.ac.uk/guidelines/fulltext/102/index.html Children & Young People (2008) SIGN 102 77 Bacterial meningitis and meningococcal septicaemia: NICE NICE http://publications.nice.org.uk/bacterial-meningitis-and- Management of bacterial meningitis and meningococcal-septicaemia-cg102 meningococcal septicaemia in children and young people younger than 16 years in primary and secondary care CG102 2010 147 Practice Guidelines for the Management of Bacterial Clin Infect Dis ; 2004 ; Tunkel AR et al http://www.idsociety.org/Organ_System/#Central Nervous Meningitis 39 : 1267 -1284 System (CNS) (This covers adults whereas UK documents just up to 16 years) 393 Guidance for public health management of HPA http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/119 meningococcal disease in the UK 4947389261 450 Early management of suspected bacterial meningitis Journal of Infection Heyderman RS http://www.britishinfection.org/drupal/sites/default/files/ and meningococcal septicaemia in adults 2003; 46: 75-77 et al meningitisJI2003.pdf 451 Early management of suspected bacterial meningitis BIS BIS http://www.britishinfection.org/drupal/sites/default/files/ and meningococcal septicaemia in adults algorithm MeningitisAlgorithm03.pdf 496 Viral Meningitis (via TKN) Dynamed http://web.ebscohost.com/dynamed/detail?sid=bdc5104f- 6727-41be-bbc3-c4bad5b4ed6a %40sessionmgr113&vid=1&hid=123&bdata=JnNpdGU9ZHl uYW1lZC1saXZlJnNjb3BlPXNpdGU %3d#db=dme&AN=114531

ENCEPHALITIS REFERENCES 452 Management of suspected viral encephalitis in adults Journal of Infection Solomon T et al http://www.journalofinfection.com/article/S0163-

42 Element 12 - MENINGITIS AND CNS INFECTION - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments – Association of British Neurologists and British 2012; 64(4);347-73 4453(11)00563-9/fulltext Infection Association National Guidelines

OTHER CNS INFECTION REFERENCES - SEE SUPPLEMENTARY RESOURSES SECTION

SUPPLEMENTARY RESOURCES Element 12 - MENINGITIS AND CNS INFECTION - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL CNS INFECTION REFERENCES 284 SWAB Guidelines on Antibacterial Therapy of Patients SWAB Dutch Working http://www.swab.nl/swab/cms3.nsf/uploads/FE54A057082 with Bacterial Central Nervous System Infections Party on AA54CC1257A2B00293B1D/$FILE/SWAB_CNSguideline_ Antimicrobial %20June12.pdf Policy

MENINGITIS REFERENCES 82 Bacterial Meningitis and meningococcal sepatcaemia NICE NICE http://publications.nice.org.uk/quality-standard-for- in children and young people (QS19) bacterial-meningitis-and-meningococcal-septicaemia-in- children-and-young-qs19 448 Antibiotics for preventing meningococcal infections CDSR 2011, Issue 8. Trestioreanu A Z http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD0 (via TKN / Athens login) Art. No.: CD004785. et al 04785.pub4/abstract;jsessionid=226C381C82289C6E38AF1 372E3BD496A.f01t03 394 Lessons from research for doctors in training: Meningitis research http://www.meningitis.org/health-professionals/doctors- recognition and early management of meningococcal foundation in-training disease in children and young people 3rd Ed

43 Element 12 - MENINGITIS AND CNS INFECTION - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments 449 Cerebrospinal fluid lactate concentration to distinguish Cochrane DARE 2011 Huy Ntet al http://onlinelibrary.wiley.com/o/cochrane/cldare/articles/ bacterial from aseptic meningitis: a systematic review Issue 3 DARE-12011001453/frame.html and meta‐analysis (Structured abstract) (via TKN / Athens login)

ENCEPHALITIS REFERENCES 148 The Management of Encephalitis: Clinical Practice Clin Infect Dis 2008 ; Tunkel AR et al http://www.idsociety.org/Organ_System/#Central Nervous Guidelines 47 : 303 -327 System (CNS)

OTHER CNS INFECTION REFERENCES 167 The Clinical Assessment, Treatment, and Prevention of Clin Infect Dis 2006 ; Wormser GP et http://www.idsociety.org/Organism/ Lyme Disease, Human Granulocytic Anaplasmosis, and 43 : 1089 -1134 al Babesiosis 454 British Infection Society guidelines for the diagnosis Journal of Infection Thwaites G et al http://www.britishinfection.org/drupal/sites/default/files/ and treatment of tuberculosis of the central nervous (2009) 59, 167-187 CNS%20TB%202009%20Thwaites.pdf system in adults and children 234 The rational use of antibiotics in the treatment of brain Br J Neurosurg Louvois J et al http://www.cwmicrobiology.nhs.uk/NeuroPDFs/brain_absc abscess (via TKN / Athens login) 2000;14(6):525-30 ess.pdf 168 Practice Parameter: Treatment of Nervous System Neurology ; 2007 ; 69 Halperin JJ et al http://www.idsociety.org/Organism/ Lyme Disease (AAN)" (Endorsed by IDSA) : 91 -102

44 Resources for Element 13 Endocarditis and Cardiovascular Infection CORE RESOURCES Element 13 - ENDOCARDITIS AND CARDIOVASCULAR INFECTION - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL ENDOCARDITIS REFERENCES Local antimicrobial guidelines on the treatment of infective endocarditis 89 Prophylaxis Against Infective Endocarditis CG64 2008 NICE NICE http://publications.nice.org.uk/prophylaxis-against- infective-endocarditis-cg64

202 Guidelines for the diagnosis and antibiotic treatment J. Gould FK et al http://jac.oxfordjournals.org/content/early/2012/02/13/ja of endocarditis in adults: a report of the Working Party Antimcrob.Chemothe c.dks039.full of BSAC r., Feb 2012; 67:269- 289 289 Guidelines on the prevention, diagnosis, and European Heart ESC Guideline http://eurheartj.oxfordjournals.org/content/30/19/2369.fu treatment of infective endocarditis (new version 2009) Journal ll 2009;30(19):2369- (one year more recent than NICE CG 64 so possibly 2413 CORE)

CARDIOVASCULAR IMPLANTABLE ELECTRONIC DEVICE INFECTION REFERENCES 145 Cardiovascular Implantable Electronic Device Circulation ; 2010 ; Baddour LM http://www.idsociety.org/Organ_System/ Infections 121 : 458 -477

45 SUPPLEMENTARY RESOURCES Element 13 - ENDOCARDITIS AND CARDIOVASCULAR INFECTION - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL ENDOCARDITIS REFERENCES 311 Infective Endocarditis Clinical Vignette(04) NB refer to PAUSE BSAC http://www.pause-online.org.uk local guidelines for specific drug therapy - good for background information only) (2 hours) 206 Guidelines for the prevention of endocarditis: report J Antimicrob Gould FK et al http://jac.oxfordjournals.org/content/57/6/1035.full.pdf of the Working Party of the British Society for Chemother 2006; Antimicrobial Chemotherapy 2006 (cited in NICE CG64) 57:1034-42 288 Infective endocarditis (via TKN / Athens login) N Engl J Med 2013; Hoen B et al http://www.knowledge.scot.nhs.uk/home/search- 368(15):1425-33 results.aspx?q=publicid:%22OVIDmedl| 23574121%22&pm=fql&expand=true&portal=

46 Resources for Element 14 Bone & Joint Infections CORE RESOURCES Element 14 - BONE AND JOINT INFECTION - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL BONE & JOINT INFECTION REFERENCES 92 Diabetic Foot Problems CG119 NICE NICE http://publications.nice.org.uk/diabetic-foot-problems- cg119 116 Use of antibiotics in people with diabetic foot disease - The Diabetic Foot Leese G et al http://www.scottishmedicines.org.uk/files/sapg/Use_of_A a consensus statement Journal Vol 12 No 2 ntibiotics_in_people_with_diabetic_foot_disease_- 2009 _Consensus_Statement_-_2009.pdf 163 Diagnosis and Management of Prosthetic Joint Clinical Infectious Osmon DR et al http://www.idsociety.org/Organ_System/#Skeletal (Bones Infection: Clinical Practice Guidelines by the Infectious Diseases ; 2013 ; 56 : & Joints) Diseases Society of America 1 -25 260 Bacterial septic arthritis in adults (via TKN / Athens Lancet 2010;375: Matthews CJ http://www.sciencedirect.com/science/article/pii/S014067 login) 846-55 3609615956 433 Treating infections in Bone & Joint in acute and OPAT NES Andrew Seaton settings

INTERACTION AND ADR REFERENCES 442 Stockley's Drug Interactions Medicines Complete http://www.medicinescomplete.com/mc/stockley/current/ 443 Electronic Medicines Compendium eMC Datapharm http://www.medicines.org.uk/emc/

47 SUPPLEMENTARY RESOURCES Element 14 - BONE AND JOINT INFECTION - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL BONE & JOINT INFECTION REFERENCES 233 Infections associated with orthopedic implants (via Curr Op Infect Dis Trampuz A et al http://www.knowledge.scot.nhs.uk/home/search- TKN / Athens login) 2006;19:349-356 results.aspx?q=publicid:%22OVIDemed7| 16804382%22&pm=fql&expand=true&portal= 259 Prosthetic Joint Associated Infections (via TKN / Athens Best Prac Res Clin Zimmerli W http://www.bprclinrheum.com/article/S1521- login) Rheumatol 6942(06)00107-0/abstract 2006;20(6):1045 321 Septic Arthritis Clinical Vignette (14) (free registration PAUSE BSAC http://www.pause-online.org.uk for HCPs) (2 hours)

48 Resources for Element 15 Gastrointestinal (GI) infections CORE RESOURCES Element 15 - GASTROINTESTINAL (GI) INFECTION - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL GI INFECTION REFERENCES 157 Guidelines for the Selection of Anti-infective Agents Clin Infect Dis 2010 ; Solomkin JS http://www.idsociety.org/Organ_System/#Intra-Abdominal for Complicated Intra-abdominal Infections 501 : 133 -164 Local Antimicrobial Prescribing Guidelines on the eradication of H pylori and other GI infections 290 EASL clinical practice guidelines on the management Journal of European http://www.sciencedirect.com/science/article/pii/S016882 of ascites, spontaneous bacterial peritonitis, and Hepatology Association for 7810004782 hepatorenal syndrome in cirrhosis (via TKN / Athens 2010;53(3):397-417 the Study of the login) Liver PERITONITIS REFERENCES 291 Spontaneous Bacterial peritonitis: recent guidelines GUT 2012;61:297- Weist R et al http://gut.bmj.com/content/61/2/297.full and beyond (via TKN / Athens login) 310

HELICOBACTER PYLORI REFERENCES 497 Test and treat for Helicobacter pylori (HP) in British Infection BIA http://www.britishinfection.org/drupal/sites/default/files/f Dyspepsia Association iles/Helicobacter%20guidance%20final%20for%20web Quick Reference Guide for Primary Care %2027_06_12.pdf

INFECTIOUS DIARRHOEA REFERENCES 477 Guidelines for the management of norovirus BIA BIA http://www.britishinfection.org/drupal/sites/default/files/f outbreaks in acute and community health and social iles/Norovirus%20report.pdf care settings 2012 490 Diarrhoea and vomiting in children NICE CG 84 2009 NICE NICE http://publications.nice.org.uk/diarrhoea-and-vomiting-in- children-cg84 379 Immunisation against infectious disease: the Green Department of https://www.gov.uk/government/organisations/public-

49 Element 15 - GASTROINTESTINAL (GI) INFECTION - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments Book (Rotavirus) Health health-england/series/immunisation-against-infectious- disease-the-green-book 340 Travax (travelers' diarrhoea) (free registration Health Protection http://www.travax.nhs.uk/ required) Scotland

PANCREATITIS REFERENCES 318 Pancreatitis Clinical Vignette (11) (free registration PAUSE BSAC http://www.pause-online.org.uk for HCPs) (60 mins)

SUPPLEMENTARY RESOURCES Element 15 - GASTROINTESTINAL (GI) INFECTION SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments HELICOBACTER PYLORI REFERENCES 405 Evidence-based guidelines from ESPGHAN and J Ped Gastro Nutr Koletzko S et al http://www.naspghan.org/user- NASPGHAN for Helicobacter pylori infection in 2011 ;53(2):230-43 assets/Documents/pdf/PositionPapers/H%20pylori%20- children %20PAP%20version.pdf 94 Dyspepsia (inc H Pylori) SIGN 68 2003 SIGN http://www.sign.ac.uk/guidelines/fulltext/68/index.html

INFECTIOUS DIARRHOEA REFERENCES 151 Practice Guidelines for the Management of Infectious Clin Infect Dis 2001 ; Guerrant RL et al http://www.idsociety.org/Organ_System/#Gastrointestinal Diarrhea 32 : 331 -350 (GI) 254 Cryptosporidiosis and its treatment CDC http://www.cdc.gov/parasites/crypto/health_professionals /tx.html 255 Diagnosis and treatment of amebiasis Clin Infect Dis Petri WA http://cid.oxfordjournals.org/content/29/5/1117.full 1999;29:1117-25 50 Element 15 - GASTROINTESTINAL (GI) INFECTION SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments

BILIARY INFECTIONS REFERENCES 458 Diagnosis and Management of Primary Sclerosing HEPATOLOGY 2010; Chapman R et al http://www.aasld.org/practiceguidelines/Documents/Pract Cholangitis 51(2): 660-78 ice%20Guidelines/PSC_2-2010.pdf

51 Resources for Element 16 - Antibiotics used in pregnancy, neonates and paediatrics CORE RESOURCES Element 16 - ANTIBIOTICS USED IN PREGNANCY, NEONATES AND PAEDIATRICS - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments PREGNANCY & LACTATION REFERENCES 238 Toxbase Monographs for drugs in pregnancy and Toxbase http://www.toxbase.org/ breastfeeding (free registration for healthcare professionals) 240 Sepsis in Pregnancy, Bacterial (Green-top 64a) 2012 RCOG http://www.rcog.org.uk/womens-health/clinical- guidance/sepsis-pregnancy-bacterial-green-top-64a 241 Sepsis following Pregnancy, Bacterial (Green-top RCOG http://www.rcog.org.uk/womens-health/clinical- 64b) 2012 guidance/sepsis-following-pregnancy-bacterial-green-top- 64b 43 Management of Suspected Bacterial Urinary Tract SIGN http://www.sign.ac.uk/guidelines/fulltext/88/index.html Infections in Adults (updated 2012) SIGN 88 478 Lactmed US National Library of http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT Medicine 479 Medications and Mothers' Milk 2012 if available Hale Publishing Hale T 491 NICE CG37 Postnatal care (also covers neonates) NICE NICE http://publications.nice.org.uk/postnatal-care-cg37 492 Antibiotics for mastitis in breastfeeding women (via Jahanfar S, Ng CJ, Cochrane http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD0 TKN / Athens login) Teng CL Database of 05458.pub3/abstract;jsessionid=1A612ACABA2A10EC5B2B Systematic EFE9CDFEF885.f01t03 Reviews 2013, Issue 2. Art. No.: CD005458 376 Drugs in Pregnancy and Lactation: A Reference Guide Lippincott Williams & Briggs G http://www.knowledge.scot.nhs.uk to Fetal and Neonatal Risk 9th ed (via TKN) Wilkins

NEONATE REFERENCES

52 Element 16 - ANTIBIOTICS USED IN PREGNANCY, NEONATES AND PAEDIATRICS - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments 83 Antibiotics in Early Onset Neonatal Infection CG149 NICE NICE http://publications.nice.org.uk/antibiotics-for-early-onset- neonatal-infection-cg149 440 Neonatal Formulary (6th ED) with updates 2011 (if Wiley Hey E (Editor) http://www.neonatalformulary.com/default.asp available)

PAEDIATRIC REFERENCES 195 British Thoracic Society guidelines for the Thorax 2011;66 (2) Harris M et al http://www.brit-thoracic.org.uk/guidelines-and-quality- management of community acquired pneumonia in standards/community-acquired-pneumonia-in-children- children: update 2011 guideline/ 462 Cystic Fibrosis Foundation evidence-based guidelines J Pediatr. 2009 Borowitz D et al http://www.guideline.gov/content.aspx?f=rss&id=43789 for management of infants with cystic fibrosis (US Dec;155(6 guidance) (via TKN / Athens login) Suppl):S73-93. 375 British National Formulary for Children (BNF-C) BMJ/RPS http://www.medicinescomplete.com/about/index.htm 77 Bacterial meningitis and meningococcal septicaemia: NICE NICE http://publications.nice.org.uk/bacterial-meningitis-and- Management of bacterial meningitis and meningococcal-septicaemia-cg102 meningococcal septicaemia in children and young people younger than 16 years in primary and secondary care CG102 (2010) 407 Bronchiolitis in children (2006) SIGN 91 SIGN SIGN http://www.sign.ac.uk/guidelines/fulltext/91/index.html 498 NICE CG 132 Guidance on Caesarian section NICE NICE http://publications.nice.org.uk/caesarean-section-cg132 91 Bronchiolitis in Children CG DRAFT NICE NICE http://guidance.nice.org.uk/ 35 Management of Invasive Meningococcal Disease in SIGN SIGN http://www.sign.ac.uk/guidelines/fulltext/102/index.html Children & Young People (2008) SIGN 102 71 Feverish Illness in Children CG160 NICE NICE http://publications.nice.org.uk/feverish-illness-in-children- cg160 74 Urinary Tract Infection in Children CG54 NICE NICE http://publications.nice.org.uk/urinary-tract-infection-in- children-cg54

53 Element 16 - ANTIBIOTICS USED IN PREGNANCY, NEONATES AND PAEDIATRICS - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments 38 Management of Sore Throat and Indication for SIGN SIGN http://www.sign.ac.uk/guidelines/fulltext/117/index.html Tonsillectomy (2010) SIGN 117 506 Introduction to paediatric pharmaceutical care (use NES NES http://www.nes.scot.nhs.uk/education-and-training/by- generic sections and chapter on childhood infection) discipline/pharmacy/about-nes-pharmacy/educational- resources/resources-by-topic/child-health/introduction-to- paediatric-pharmaceutical-care.aspx

SUPPLEMENTARY RESOURCES Element 16 - ANTIBIOTICS USED IN PREGNANCY, NEONATES AND PAEDIATRICS - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments PREGNANCY & LACTATION REFERENCES 402 Preterm Prelabour Rupture of Membranes (Green RCOG http://www.rcog.org.uk/files/rcog- Top 44) corp/GTG44PPROM28022011.pdf 404 Recommended strategies for Intrapartum perinatology.com http://www.perinatology.com/protocols/GBS.htm Antimicrobial Prophylaxis (IAP) for Perinatal Group B Streptococcal Disease. 211 Timing of prophylactic antibiotics for preventing CDSR 2011, Issue 12. Baxter JK et al http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD0 postpartum infectious morbidity in women Art. No.: CD009516 09516/full undergoing cesarean delivery (Protocol) (via TKN / Athens login) 239 Antibacterial medication use during pregnancy and Arch Pediat Adolesc Crider KS et al http://archpedi.jamanetwork.com/article.aspx? risk of birth defects Med articleid=382406 2009;163(11):978-85 455 Antibiotic Use in Pregnancy and Lactation OBSTETRICS & Nahum GG et al http://www.amchp.org/programsandtopics/womens-

54 Element 16 - ANTIBIOTICS USED IN PREGNANCY, NEONATES AND PAEDIATRICS - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GYNECOLOGY 2006; health/CDC/ANTIBIOTICS/Nahum.pdf 107(5): 1120-38 246 Group B Streptococcal Disease, Early Onset (Green- RCOG http://www.rcog.org.uk/womens-health/clinical- top 36) 2012 guidance/prevention-early-onset-neonatal-group-b- streptococcal-disease-green- 247 Genital Herpes in Pregnancy, Management (Green- RCOG http://www.rcog.org.uk/womens-health/clinical- top 30) 2007 guidance/management-genital-herpes-pregnancy-green- top-30 248 Chickenpox in Pregnancy (Green-top 13) 2007 RCOG http://www.rcog.org.uk/womens-health/clinical- guidance/chickenpox-pregnancy-green-top-13

NEONATE REFERENCES 285 Management of antibiotic-resistant infection in the Arch Dis Child Educ Gray JW et al http://ep.bmj.com/content/96/4/122.full newborn (via TKN / Athens login) Pract Ed 2011;96:122-127 287 Improving antibiotic prescribing in neonatal units: Arch Dis Child Fetal Bedford Russell http://fn.bmj.com/content/97/2/F141.full time to act (via TKN / Athens login) Neonat Ed A 2012;97:F141-F146 457 Clinical pharmacokinetics of vancomycin in the Clinics (Sao Paulo). Pacifici GM http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400177/ neonate: a review(to be covered by A Thomson in 2012 July; 67(7): Allegaert K P'kinetics section) 831–837 403 Recommendations for the Prevention of Perinatal PEDIATRICS 2011.128 http://pediatrics.aappublications.org/content/early/2011/0 Group B Streptococcal (GBS) Disease Policy (3): 1-6 7/28/peds.2011-1466.full.pdf Statement American Academy of Paediatrics 2011 456 Clinical Pharmacokinetics of Penicillins, Pharmaceuticals Pacifici, G.M http://www.mdpi.com/1424-8247/3/8/2568 Cephalosporins and Aminoglycosides in the Neonate 2010; 3 (8): 2568- 2591.

55 Element 16 - ANTIBIOTICS USED IN PREGNANCY, NEONATES AND PAEDIATRICS - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments PAEDIATRIC REFERENCES 408 Guidelines on Paediatric Urology (European EAU Tekgul S et al http://www.uroweb.org/gls/pdf/21_Paediatric_Urology_LR Association of Urology 2012) _August%202012.pdf 411 Recommendations for treatment of childhood non- Lancet Infect Dis Grant GB et al http://blog.utp.edu.co/maternoinfantil/files/2010/08/Guia severe pneumonia (via TKN / Athens login) 2009;9: 185-96 _Lancet_Neumonia_severa.pdf 412 Antibiotics for acute otitis media in children (Review) Cochrane Venekamp RP et http://summaries.cochrane.org/CD000219/antibiotics-for- Jan2013 (via TKN / Athens login) al middle-ear-infection-acute-otitis-media-in-children 453 Management of suspected viral encephalitis in Journal of Infection Kneen R et al http://www.journalofinfection.com/article/S0163- children – Association of British Neurologists and 2012; 64(5); 449-77 4453(11)00562-7/fulltext British Paediatric Allergy, Immunology and Infection Group National Guidelines 95 Cystic fibrosis (pseudomonas lung infection) - NICE NICE http://publications.nice.org.uk/colistimethate-sodium-and- colistimethate sodium and tobramycin TA276 (2013) tobramycin-dry-powders-for-inhalation-for-treating- pseudomonas-lung-ta276 490 Diarrhoea and vomiting in children NICE CG 84 2009 NICE NICE http://publications.nice.org.uk/diarrhoea-and-vomiting-in- children-cg84 366 Atopic eczema in children: Management of atopic NICE NICE http://publications.nice.org.uk/atopic-eczema-in-children- eczema in children from birth up to the age of 12 cg57 years 406 Guidelines on the Management of Acute and Chronic Scottish Paediatric Renal Unit, http://www.clinicalguidelines.scot.nhs.uk/Renal%20Unit Peritoneal Dialysis Renal and Urology Yorkhill %20Guidelines/YOR-REN-030%20Management%20of Network %20Acute%20and%20Chronic%20Peritoneal%20Dialysis %20Oct%2010%20Revision%201.pdf 198 BTS guidelines for the management of pleural Thorax Balfour-Lynne http://www.brit-thoracic.org.uk/guidelines-and-quality- infection in children 2005;60(Suppl I):i1– IM standards/pleural-infection-in-children/ i21

56 57 Resources for Element 17 Sexually transmitted infection (STI), human immunodeficiency virus (HIV) & other blood borne virus (BBV) CORE RESOURCES Element 17 - STI, HIV AND OTHER BBV - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL STI/BBV/HIV REFERENCES 64 HIV-STI Pathology (free registration for HCPs) (90 e-Learning for Health NHS http://www.e-lfh.org.uk/home/ minutes)

STI REFERENCES 40 Management of Genital Chlamidia tracomatis SIGN http://www.sign.ac.uk/guidelines/fulltext/109/index.html Infection (2009) SIGN 109 417 Sexually Transmitted Infections in Primary Care BASSH http://www.bashh.org/documents/Sexually (although primary care is good summary document) %20Transmitted%20Infections%20in%20Primary%20Care %202013.pdf 65 HIV-STI Bacterial STIs and related conditions (free e-Learning for Health NHS http://www.e-lfh.org.uk/home/ registration required for HCPs) (2 hours and 30 mins) 66 HIV-STI Genital Ulcer Disease (including syphilis) (free e-Learning for Health NHS http://www.e-lfh.org.uk/home/ registration required for HCPs) (60 mins) 413 UK National Guideline for the Management of Pelvic BASSH http://www.bashh.org/documents/3572.pdf Inflammatory Disease 2011

BBV REFERENCES 68 HIV-STI Viral Hepatitis (free registration required for e-Learning for Health NHS http://www.e-lfh.org.uk/home/ HCPs) (3 hours) 85 Hepatitis B (chronic) diagnosis and management in NICE NICE http://publications.nice.org.uk/hepatitis-b-chronic-cg165 children & adults (CG 165) 362 Hepatitis Drug Interactions Website (Liverpool Liverpool University http://www.hep-druginteractions.org/ University)

58 Element 17 - STI, HIV AND OTHER BBV - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments 363 SIGN 133: Management of Hepatitis C (July 2013) SIGN http://www.sign.ac.uk/guidelines/fulltext/133/index.html 424 UK consensus guidelines for the use of the protease Aliment Pharmacol Ramachandran P http://onlinelibrary.wiley.com.proxy.knowledgeservices.or inhibitors boceprevir and telaprevir in genotype 1 Ther 2012; 35(6): et al g/doi/10.1111/j.1365-2036.2012.04992.x/full chronic hepatitis C infected patients (via TKN / 647-62 Athens login) 425 EASL Issue 8 (April 2012) Revised Clinical Practice Journal of EASL http://www.easl.eu/_clinical-practice-guideline/issue-8- Guidelines on the Management of Chronic Hepatitis Hepatology 2012 april-2012-revised-clinical-practice-guidelines-on-the- B with corrigendum (57 ):167–185 management-of-chronic-hepatitis-b

HIV REFERENCES 69 HIV-STI 12 Specific Assessment and Management of e-Learning for Health NHS http://www.e-lfh.org.uk/home/ HIV (free registration required for HCPs) (60 mins) 361 HIV Drug Interactions Website (Liverpool University) Liverpool University http://www.hiv-druginteractions.org/ 401 BHIVA and BIA Guidelines for the Treatment of BHIVA http://www.bhiva.org/documents/Guidelines/OI/hiv_v12_i Opportunistic Infection in HIV-seropostive individuals s2_Iss2Press_Text.pdf 2011 418 BHIVA guidelines summaries for patients BHIVA http://www.bhiva.org/guidelines-summaries.aspx 419 Introduction to combination therapy (good summary iBase http://i-base.info/guides/starting document for those new to subject) 485 Impact of antiretroviral dosing frequency and pill Int J STD & AIDS Buscher A et al http://web.ebscohost.com/ehost/pdfviewer/pdfviewer? burden on adherence among newly diagnosed, 2012; 23: 351–355 sid=46854a08-b84e-4bf3-968c- antiretroviral-naïve HIV patients (via TKN / Athens c34143b42056%40sessionmgr114&vid=2&hid=123 login) 486 Adherence to Therapy, Treatment Success, and the Infect Diseases in Clin Jain SK et al http://ovidsp.uk.ovid.com/sp-3.11.0a/ovidweb.cgi? Prevention of Resistance (via TKN / Athens login) Pract; 14(4):S15-18 WebLinkFrameset=1&S=IDKNPDKFDKHFCDMBFNNKCBBGK 2006 HCPAA00&returnUrl=ovidweb.cgi%3f%26TOC %3dS.sh.22.23.27.31%257c5%257c50%26FORMAT%3dtoc %26FIELDS%3dTOC%26S %3dIDKNPDKFDKHFCDMBFNNKCBBGKHCPAA00&directlink 59 Element 17 - STI, HIV AND OTHER BBV - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments =http%3a%2f%2fgraphics.uk.ovid.com%2fovftpdfs %2fPDHFFNBGCBMBDK00%2ffs046%2fovft%2flive %2fgv023%2f00019048%2f00019048-200607004- 00005.pdf&filename=Adherence+to+Therapy %2c+Treatment+Success %2c+and+the+Prevention+of+Resistance.&PDFIdLinkField= %2ffs046%2fovft%2flive %2fgv023%2f00019048%2f00019048-200607004- 00005&link_from=S.sh.22.23.27.31%7c5&pdf_key=B&pdf_i ndex=S.sh.22.23.27.31&D=ovft 487 Novel modular teaching of HIV patients and effect on Tropical Med & Int Busari O http://onlinelibrary.wiley.com.proxy.knowledgeservices.or adherence to HAART (via TKN / Athens login) Health 17(s1: 18 g/doi/10.1111/j.1365-3156.2011.02994_1.x/pdf 2012

SUPPLEMENTARY RESOURCES Element 17 - STI, HIV AND OTHER BBV - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL STI/BBV/HIV REFERENCES 93 NES Sexual and Reproductive Health NES www.portal.scot.nhs.uk 128 Sexual Health in General Practice (2 hours) RCGP http://elearning.rcgp.org.uk/course/view.php? search=infection&morelesson=1&id=33 410 UK National Guideline on the Management of BASSH http://www.bashh.org/documents/2674.pdf Sexually Transmitted Infections and Related Conditions in Children and Young People 2010

60 Element 17 - STI, HIV AND OTHER BBV - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments 420 Clinical Care Options Website (free registration for Clinical Care Options http://www.clinicaloptions.com/ HCPs) (CCO)

STI REFERENCES 46 Neisseria gonorrhea – the first untreatable infection BSAC Prof Catherine http://bsac.org.uk/events/past-events-2013/bsac-spring- Ison meeting-2013/bsac-spring-meeting-agm-2013-videos/ 67 HIV-STI HPV Infection (free registration required for e-Learning for Health NHS http://www.e-lfh.org.uk/home/ HCPs) 3 hours) 247 Genital Herpes in Pregnancy, Management (Green- RCOG http://www.rcog.org.uk/womens-health/clinical- top 30) 2007 guidance/management-genital-herpes-pregnancy-green- top-30 249 BASHH Clinical Effectiveness Group Guidelines (have BASSH http://www.bashh.org/BASHH/Guidelines/Guidelines/BAS referred to specific guidelines elsewhere) HH/Guidelines/Guidelines.aspx

BBV REFERENCES 76 Hepatitis B - Tenofovir disoproxil TA173 NICE NICE http://publications.nice.org.uk/tenofovir-disoproxil-for-the- treatment-of-chronic-hepatitis-b-ta173 80 Hepatitis C (genotype 1) - Telaprevir TA252 NICE NICE http://publications.nice.org.uk/telaprevir-for-the- treatment-of-genotype-1-chronic-hepatitis-c-ta252 81 Hepatitis C (genotype 1) - Boceprevir TA253 NICE NICE http://publications.nice.org.uk/boceprevir-for-the- treatment-of-genotype-1-chronic-hepatitis-c-ta253 86 Hepatitis C (Children and Young People) NICE NICE http://publications.nice.org.uk/peginterferon-alfa-and- Peginterferon Alfa & Ribavirin TA300 ribavirin-for-treating-chronic-hepatitis-c-in-children-and- young-people-ta300 152 Diagnosis, Management and Treatment of Hepatitis C HEPATOLOGY ; 2011 ; Ghany MG et al http://www.idsociety.org/Organism/ (AASLD) 54 : 1433 -1444 423 European Association for the Study of Liver EASL www.easl.eu

61 Element 17 - STI, HIV AND OTHER BBV - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments 484 Interferon: an important step forward in treating The Pharmaceutical Bryan J http://www.pjonline.com/news/interferon_an_important_ hepatitis C infection (Registration required with RPS - Journal2008;280:753 step_forward_in_treating_hepatitis_c_infection fee) 481 Sequential treatment of cytomegalovirus infection or Transpl Infect Dis Caldes A et al http://web.ebscohost.com/ehost/pdfviewer/pdfviewer? disease with a short course of intravenous ganciclovir 2010: 12: 204-212 vid=3&sid=51827a71-396d-4372-819a- followed by oral valganciclovir: efficacy. safety, and 6142e11537d4%40sessionmgr112&hid=112 pharmacokinetics (via TKN - Athens login) HIV REFERENCES 252 BHIVA Guidelines (have referred to specific BHIVA http://www.bhiva.org/ClinicalGuidelines.aspx guidelines elsewhere) 250 HIV infection pathology and disease progression Clinical Pharmacist Weston R et al http://www.pjonline.com/search/all? (registration with RPS required - fee) 2009;1: 387 filter0=hiv+infection+pathology+and+disease+progression& filter8=weston&filter7%5BClinical+Pharmacist %5D=Clinical+Pharmacist&filter4=&filter5=&filter6=&filter3 %5Bcpd_article %5D=cpd_article&filter2=**ALL**&filter1=**ALL**& 254 Cryptosporidiosis and its treatment CDC http://www.cdc.gov/parasites/crypto/health_professionals /tx.html 415 Treating opportunistic infections in HIV-infected CHIVA http://www.chiva.org.uk/professionals/health/guidelines/c children omplications/treating-oi.html 416 Guidelines for the management of HIV infection in BHIVA http://www.bhiva.org/PregnantWomen2012.aspx pregnant women 2012 181 Guidelines for the Prevention and Treatment of The Pediatric Siberry GK et al http://www.idsociety.org/Organism/ Opportunistic Infections Among HIV-Exposed and Infectious Disease HIV-Infected Children Journal November 6, 2013 421 HIV pharmacists association (free registration HIV PA hivpa.org required for pharmacists) 422 Guidelines for the Management of Hepatitis Viruses BHIVA http://www.bhiva.org/hepatitis-2013.aspx 62 Element 17 - STI, HIV AND OTHER BBV - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments in Adults Infected with HIV 2013 483 The Role of Therapeutic Drug Monitoring in the Therapeutic Drug Pretorius E et al http://ovidsp.uk.ovid.com/sp-3.11.0a/ovidweb.cgi? Management of Patients With Human Monitoring. 33 &S=MIDNPDEEBFHFCDNLFNNKAHAGECGOAA00&Link+Set= Immunodeficiency Virus Infection (via TKN / Athens (3):265-74 2011 S.sh.22.23.27.31%7c1%7csl_11297244 login)

426 Toronto General Hospital Immunodeficiency Clinic Toronto General http://hivclinic.ca/main/drugs_home.html Drug Information/Interactions Hospital 488 Pharmacists: Partners in Health Care for HIV-Infected NY State DoH AIDS http://www.hivguidelines.org/clinical-guidelines/hiv-and- Patients Institute 2000-2013 pharmacy/pharmacists-partners-in-health-care-for-hiv- infected-patients/ 302 ABC of HIV and AIDS 6th Ed 2012 if available (comes BMJ Books Wiley Alder MW highly recommended but would need to be Blackwell purchased)

63 Resources for Element 18 Tropical infectious diseases CORE RESOURCES Element 18 - TROPICAL INFECTIOUS DISEASES - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL TROPICAL DISEASES REFERENCES 340 Travax (Free registration required for HCPs or possibly Health Protection http://www.travax.nhs.uk/ access via The Knowledge Network) Scotland

MALARIA REFERENCES 469 Guidelines for malaria prevention in travelers from the Public Health England Chiodini PL et al http://www.hpa.org.uk/webw/HPAweb&HPAwebStandard United Kingdom 2013 /HPAweb_C/1195733823080?p=1191942128258 243 Malaria in pregnancy prevention (Green-top 54A) 2010 RCOG http://www.rcog.org.uk/prevention-malaria-pregnancy- green-top-54a 244 Malaria in pregnancy diagnosis & treatment (Green- RCOG http://www.rcog.org.uk/diagnosis-and-treatment-malaria- top 54B) 2010 pregnancy-green-top-54b 349 The British Infection Society UK Malaria Treatment Journal of Infection Laloo DG et al http://www.britishinfection.org/drupal/sites/default/files/ Guidelines (2007) (2007); 54: 111-121 malariatreatmentBIS07.pdf 351 The British Infection Society Malaria Algorithm for BIS http://www.britishinfection.org/drupal/sites/default/files/ Diagnosis & Initial Management MalariaAlgorithm07.pdf

OTHER TROPICAL DISEASES REFERENCES 255 Diagnosis and treatment of amebiasis Clin Infect Dis Petri WA http://cid.oxfordjournals.org/content/29/5/1117.full 1999;29:1117-25 257 Review: Diagnosis and Management of Schistosomiasis BMJ2011;342:d2651 Gray DJ et al http://www.bmj.com/content/342/bmj.d2651 (via TKN / Athens login) 427 Rabies: Guidance on Prophylaxis and Management in Health Protection http://www.documents.hps.scot.nhs.uk/about- Humans in Scotland Scotland hps/hpn/rabies-guidelines-2013.pdf 428 Leishmaniasis Clin Med 2011; 11(5): Moore EM, http://www.clinmed.rcpjournal.org/content/11/5/492.full. 492-7 Lockwood DN pdf

64 Element 18 - TROPICAL INFECTIOUS DISEASES - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments 355 WHO Ebola, Marburg and Crimean Congo WHO http://www.who.int/mediacentre/factsheets/en/ Haemorrhagic Fever Factsheets 222 The evolving threat of antimicrobial resistance WHO http://whqlibdoc.who.int/publications/2012/97892415031 81_eng.pdf

SUPPLEMENTARY RESOURCES Element 18 - TROPICAL INFECTIOUS DISEASES - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL TROPICAL DISEASE REFERENCES 342 National Travel Health Network and Centre NaTHNaC http://www.nathnac.org/pro/index.htm 343 CDC Health Information for International Travel CDC http://wwwnc.cdc.gov/travel/page/yellowbook-home-2012 (Yellow Book) 345 Travel Health (60 mins) NES http://www.nes.scot.nhs.uk/media/1912665/travel_health _interactive.pdf 379 Immunisation against infectious disease: the green DoH https://www.gov.uk/government/organisations/public- book health-england/series/immunisation-against-infectious- disease-the-green-book 429 Hunter's Tropical Medicine and Emerging Infectious Elsevier Magill AJ et al Disease: Expert Consult -2013 Online and Print, 9e if (ED) available 430 Manson's Tropical Diseases 23rd Edition 2013 if Elsevier Farrar J et al (Ed) available

MALARIA REFERENCES 348 The London Hospital of Tropical Medicine Malaria The Hospital for http://www.thehtd.org/Malaria

65 Element 18 - TROPICAL INFECTIOUS DISEASES - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments Guidelines 2013 Tropical Diseases %20guideline_final_June2013.pdf 350 The British Infection Society New Guidelines on Journal of Infection Swales CA et al http://www.britishinfection.org/drupal/sites/default/files/ Malaria Prevention: A Summary (2007); 54: 107-110 malariapreventionBIS07.pdf

OTHER TROPICAL DISEASES REFERENCES 354 WHO Expert Consultation on Rabies WHO http://apps.who.int/iris/bitstream/10665/85346/1/978924 1209823_eng.pdf

66 Resources for Element 19 Chronic respiratory tract infections - tuberculosis (TB), cystic fibrosis (CF) and non-CF bronchiectasis CORE RESOURCES Element 19 - CHRONIC RESPIRATORY INFECTION - TB, CF & BRONCHIECTASIS - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments TUBERCULOSIS REFERENCES 70 Tuberculosis NICE CG 117 NICE NICE http://publications.nice.org.uk/tuberculosis-cg117

197 Guidelines for the prevention and management of Thorax Milburn H et al http://www.brit-thoracic.org.uk/guidelines-and-quality- Mycobacterium tuberculosis infection and disease in 2010;65:559e570 standards/tuberculosis-guideline/ adult patients with chronic kidney disease 258 Extensively drug-resistant tuberculosis (via TKN / Lancet Infect Dis Jassal M http://www.ncbi.nlm.nih.gov/pubmed/18990610 Athens login) 2009;9: 19-30 298 WHO Guidelines for the programmatic management of WHO http://whqlibdoc.who.int/publications/2011/97892415015 drug-resistant tuberculosis 2011 83_eng.pdf

CYSTIC FIBROSIS REFERENCES 464 Antibiotic Treatment for Cystic Fybrosis – 3rd Edition Cystic Fibrosis Trust https://www.cysticfibrosis.org.uk/media/82010/CD_Antibi Report of the UK Cystic Fibrosis Trust Antibiotic otic_treatment_for_CF_May_09.pdf Working Group 95 Cystic fibrosis (pseudomonas lung infection) - NICE NICE http://publications.nice.org.uk/colistimethate-sodium-and- colistimethate sodium and tobramycin TA276 (2013) tobramycin-dry-powders-for-inhalation-for-treating- pseudomonas-lung-ta276 501 Oxford Textbook of Medicine 2003 see chapter on Oxford University Warrell D www.knowledge.scot.nhs.uk cystic fibrosis (via TKN) Press

NON-CF BRONCHIECTASIS REFERENCES 192 The BTS Guideline for non-CF Bronchiectasis Thorax (Volume 65, Pasteur MC et al http://www.brit-thoracic.org.uk/guidelines-and-quality- Supplement 1) 2010 standards/bronchiectasis-guideline/

67 SUPPLEMENTARY RESOURCES Element 19 - CHRONIC RESPIRATORY INFECTION - TB, CF & BRONCHIECTASIS - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments TUBERCULOSIS REFERENCES 169 Diagnosis, Treatment and Prevention of Am J Resp Crit care Griffith DE et al http://www.idsociety.org/Organism/ Nontuberculous Mycobacterial Diseases Med 2007 ; 175 : 367 -416 199 Management of opportunist mycobacterial infections: Thorax 2000;55:210– Campbell IA et al http://www.brit-thoracic.org.uk/guidelines-and-quality- Joint Tuberculosis Committee guidelines 1999 218 standards/non-tuberculous-mycobacteria/ 297 WHO Treatment of tuberculosis: guidelines for WHO http://www.who.int/tb/publications/tb_treatmentguidelin national programmes 4th Ed 2009 es/en/index.html 317 Tuberculosis Clinical Vignette (10)( free registration PAUSE BSAC http://www.pause-online.org.uk required for HCPs) Good if limited access to patients with TB (3 hours) 323 Tuberculosis Clinical Vignette (16)(free registration PAUSE BSAC http://www.pause-online.org.uk required for HCPs) ) Good if limited access to patients with TB (2 hours) 454 British Infection Society guidelines for the diagnosis Journal of Infection Thwaites G et al http://www.britishinfection.org/drupal/sites/default/files/ and treatment of tuberculosis of the central nervous (2009) 59, 167-187 CNS%20TB%202009%20Thwaites.pdf system in adults and children

CYSTIC FIBROSIS REFERENCES 445 Cystic Fibrosis & OPAT - What can we learn? BSAC Iara-Mina http://e-opat.com/downloads Sequeios 463 Antibiotic Prescribing Guidelines in Adults with Cystic NHS Lothian & McCabe D et al http://www.nhstaysideadtc.scot.nhs.uk/Antibiotic Fibrosis - 2011 Adapted for Use in NHS Tayside April Tayside %20site/pdf%20docs/Adult%20CF%20Antibiotic 2012 Example of local adaptation of Cystic Fibrosis %20guideline%20Tayside%20adaptation%202012.pdf Trust Guidance

68 Element 19 - CHRONIC RESPIRATORY INFECTION - TB, CF & BRONCHIECTASIS - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments 461 Standards of care for patients with cystic fibrosis: a Journal of cystic Barreto C et al http://www.sciencedirect.com/science/article/pii/S156919 European consensus fibrosis 2005; 4: 7 – 9304002139 26 462 Cystic Fibrosis Foundation evidence-based guidelines J Pediatr. 2009 Borowitz D et al http://www.guideline.gov/content.aspx?f=rss&id=43789 for management of infants with cystic fibrosis. Dec;155(6 Suppl):S73-93. 500 Cystic Fibrosis Pharmacological Management Clinical Pharmacist Smyth S http://www.pjonline.com/clinical- (registration required with RPS - fee) 2011;3:245 pharmacist/2011_sep/cystic_fibrosis_pharmacological_ma nagement 499 Cystic Fibrosis Physiology and Diagnosis (registration Clinical Pharmacist Cuevas OA http://www.pjonline.com/clinical- required with RPS - fee) 2011;3: 239 pharmacist/2011_sep/cystic_fibrosis_pathophysiology_dia gnosis

69 Resources for Element 20 Fungal infections CORE RESOURCES Element 20 - FUNGAL INFECTION - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL FUNGAL AND ANTIFUNGAL REFERENCES Available textbook(s) for background information 367 Fungal Skin and Nail Infections Primary Care Quick HPA http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/124 Reference Guide 0294785726 431 NICE CKS Guidelines on Fungal nail & skin infections NICE NICE CKS http://cks.nice.org.uk/ 432 Guidelines on the management of invasive fungal British Committee on Prentice AG et al http://www.bcshguidelines.com/documents/fungal_infecti infection during therapy for haematological Standards in on_bcsh_2008.pdf malignancy Haematology 171 Treatment of Aspergillosis Clin Infect Dis 2008 ; Walsh TJ et al http://www.idsociety.org/Organism/ 46 : 327 -360 174 Practice Guidelines for the Management of Clin Infect Dis 2010 ; Perfect JR http://www.idsociety.org/Organism/ Cryptococcal Disease 50 : 291 -322 175 Guidelines for The Management of Candidiasis Clin Infect Dis 2009 ; Pappas PG http://www.idsociety.org/Organism/ 42 : 503 -535 Local guidelines for e.g. management of Pneumocystic jirovecii

THERAPEUTIC DRUG MONITORING REFERENCES 503 Therapeutic drug monitoring (TDM) of antifungal J Antimicrob Ashbee HR et al http://jac.oxfordjournals.org/content/early/2013/12/28/ja agents: guidelines from the British Society for Medical Chemother (2013) c.dkt508.full?hwoaspck=true&sid=94fb36c1-9153-44c8- Mycology doi: b5a5-bddaddddb708 10.1093/jac/dkt508

70 SUPPLEMENTARY RESOURCES Element 20 - FUNGAL INFECTION - SUPPLEMENTARY RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL FUNGAL AND ANTIFUNGAL REFERENCES 50 Directed therapy for fungal infections – latest BSAC Dr Rosemary http://bsac.org.uk/events/past-events-2013/bsac-spring- advances (30 mins) Barnes meeting-2013/bsac-spring-meeting-agm-2013-videos/ 465 An Official American Thoracic Society Statement: Am J Respir Crit Care Limper AH et al http://www.thoracic.org/statements/resources/tb- Treatment of Fungal Infections in Adult Pulmonary and Med 2011; 183: 96– opi/treatment-of-fungal-infections-in-adult-pulmonary- Critical Care Patients (also covers Pneumocystic 128 critical-care-and-sleep-medicine.pdf jirovecii) 172 Clinical Practice Guidelines for the Management of Clin Infect Dis 2008 ; Chapman SW http://www.idsociety.org/Organism/ Blastomycosis 46 : 1801 -1812 173 Practice Guidelines for the Treatment of Clin Infect Dis 2005 ; Galgiani JN http://www.idsociety.org/Organism/ Coccidioidomycosis 41 : 1217 -1223 176 Clinical Practice Guidelines for the Management of Clin Infect Dis 2007 ; Wheat LJ http://www.idsociety.org/Organism/ Patients with Histoplasmosis: 2007 Update by the 45 : 807 -825 Infectious Diseases Society of America" 177 Clinical Practice Guidelines for the Management of Clin Infect Dis 2007 ; Kauffman CA http://www.idsociety.org/Organism/ Sporotrichosis: 2007 Update by the Infectious Diseases 45 : 1255 -1265 Society of America

THERAPEUTIC DRUG MONITORING REFERENCES 480 Optimizing antifungal choice and administration (via Curr Med Research Andes D http://informahealthcare.com.proxy.knowledgeservices.or TKN / Athens login) Opin. 29, Sup 4, g/doi/pdf/10.1185/03007995.2012.761135 2013, 13–18

71 Resources for Element 21 Outpatient parenteral antimicrobial therapy (OPAT) CORE RESOURCES Element 21 - OPAT - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL OPAT REFERENCES 190 Good practice recommendations for outpatient JAC (2012) 67 (5): Chapman ALN et http://jac.oxfordjournals.org/content/67/5/1053.full parenteral antimicrobial therapy (OPAT) in adults in 1053-1062. al the UK: a consensus statement 268 Pharmaceutical Care in OPAT (via TKN) (15 mins) ASAP Shared Space Robb F http://www.elib.scot.nhs.uk/SharedSpace/pharmacy/Pages /RecordDetailFull.aspx?nid=229082&ret=http%3a%2f %2fwww.elib.scot.nhs.uk%2fSharedSpace%2fpharmacy %2fPages%2fRecordDetailShort.aspx%3fnid %3d229082%26ret%3d%2fSharedSpace%2fpharmacy %2fPages%2fIndex.aspx%3 328 Outpatient Parenteral Antibiotic Therapy (OPAT) PAUSE BSAC http://www.pause-online.org.uk Clinical Vignette (21) (free registration for HCPs) (3 hours) 504 eOPAT website BSAC BSAC http://e-opat.com/ 56 Microbiology - present and future (20 mins) BSAC Nick Brown http://e-opat.com/downloads/

SPECIFIC CONDITIONS OR DRUGS IN OPAT REFERENCES 55 Role of OPAT in DFI - benefits, drugs, issues (10 mins) BSAC Paul http://e-opat.com/downloads/ Chadwick/Claire McIntosh 433 Treating infections in Bone & Joint in acute and OPAT NES Andrew Seaton settings 434 Treating infections in Skin & Soft Tissue in acute and NES Andrew Seaton http://vimeo.com/79984822 OPAT settings (60 mins) 189 Development of teicoplanin dosage guidelines for JAC (2009) 64 (1): Lamont E et al http://jac.oxfordjournals.org/content/64/1/181.full

72 Element 21 - OPAT - CORE RESOURCES Date Resource Resource Presenter Accessed/ ID Name of resource Resource owner /Author URL link direct to resource Comments patients treated within an (OPAT) programme 181-187.

SUPPLEMENTARY RESOURCES Element 21 - OPAT - SUPPLEMENTARY RESOURCES Date Resource Resour Presenter Accessed/ ce ID Name of resource Resource owner /Author URL link direct to resource Comments GENERAL OPAT REFERENCES Practice Guidelines for Outpatient Parenteral Clin Infect Dis ; 2004 ; Tice AD et al http://www.idsociety.org/Antimicrobial_Agents/#Outpatie 142 Antimicrobial Therapy 38 : 1651 -1672 nt Parenteral Anti-Infective Therapy (OPAT) 444 What are the ideal OPAT agents? (20 mins) BSAC DR Robin Howe http://e-opat.com/downloads 191 Parenteral antimicrobial therapy for the treatment of Eur Infectious Nathwani D et al www.touchbriefings.com/ebooks/A1nob5/euinfect31/reso serious infection in the ambulatory setting-the Disease 2009: 70-74 urces/72htm European perspective (need flash player)

SPECIFIC CONDITIONS OR DRUGS IN OPAT REFERENCES 445 Cystic Fibrosis & OPAT - What can we learn? BSAC Iara-Mina http://e-opat.com/downloads Sequeios 505 Risk factors for failure of outpatient parenteral J Antimicrob Duncan CJA et al http://jac.oxfordjournals.org/content/68/7/1650 antibiotic therapy (OPAT) in infective endocarditis Chemother (2013) 68 (7): 1650-1654.

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