Supplement 1: Meta-Analysis of VBM Studies with SDM

Supplement 1: Meta-Analysis of VBM studies with SDM Title: Voxelwise Meta-analysis of White Matter Abnormalities in Progressive Supranuclear Palsy Authors: Jing Yang, MD, Na Shao, MD, JianPeng Li, MD, HuiFang Shang, MD Affiliation and e-mail address of correspondence Author: Hui-Fang Shang, MD, Department of Neurology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. Tel: 0086-18980602127, FAX: 0086-028-85423550. E-mail: [email protected].

Meta-Analysis of VBM studies with SDM The regional differences of WM changes in patients with PSP and HC were analyzed using ES-SDM (version 2.31, http://www.sdmproject.com), which has been described in detail elsewhere [1,2]. Briefly, all foci were first transformed to Talairach kernel in order to account for various sources of spatial error (FWHM=20mm). After an effect-size signed map of the GM differences was separately recreated for each study, the mean map was obtained by calculating the mean of the study maps, weighted by the inverse of each study variance, which accounted for inter-study heterogeneity. Finally, a threshold was set for the meta-analytic maps using a voxel-level threshold of p ＜ 0.001(uncorrected) and a cluster-level threshold of 10 voxels. Additional jackknife sensitivity analyses were further conducted by excluding one of the samples each time to assess the robustness of the results across different studies. Results Descriptive quartile analysis revealed that WM reductions were detected in one large cluster extending from bilateral midbrain to regions close to thalamus and basal ganglia (peak Talairach coordinate x= 4, y= -12, z= -6, SDM=-4.505, p＜ 0.00001, 2591 voxels) [Fig 3]. No WMV increase was observed. These results remained largely unchanged following jackknife sensitivity analysis.

Fig 3 Coronal, sagittal, and axial sections for white matter reductions in PSP patients compared with healthy control References 1. Bora E, Fornito A, Yucel M, Pantelis C (2010) Voxelwise meta-analysis of gray matter abnormalities in bipolar disorder. Biol Psychiatry 67 (11):1097-1105. doi:10.1016/j.biopsych.2010.01.020 2. Li J, Pan P, Huang R, Shang H (2012) A meta-analysis of voxel-based morphometry studies of white matter volume alterations in Alzheimer's disease. Neurosci Biobehav Rev 36 (2):757-763. doi:10.1016/j.neubiorev.2011.12.001