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JOURNAL CLUB ARCHIVE Kosaku Direct Proteomic Quantification of the Secretome of 12/16/13 Shinoda Activated Immune Cells An Integrated Serotonin and Octopamine Neuronal 12/9/13 Bill Krause Circuit Directs the Release of an Endocrine Signal to Control C. elegans Body Fat Martin Mitofusin 2 in POMC Neurons Connects ER Stress with 12/2/13 Valdearcos Leptin Resistance and Energy Imbalance Contreras Ernie Evidence for NG2-glia Derived, Adult-Born Functional 11/18/13 Yulyaningsih Neurons in the Hypothalamus Dendritic Peptide Release Mediates Interpopulation 10/21/13 Shi-Bing Yang Crosstalk between Neurosecretory and Preautonomic Networks MitoNEET-driven alterations in adipocyte mitochondrial 10/14/13 Dylan Lowe activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity Jose Heredia (Chawla Lab) and Stuart Smith (German Lab) in 10/1/13 MetaboRIPS Gladstone Conf Rm C&D at 4 pm (note special day of the (*Tuesday*) week) Jess Porter Identification of an Adipogenic Niche for Adipose Tissue 9/23/13 Abate Remodeling and Restoration Tracking adipogenesis during white adipose tissue 9/16/13 Linet Mera development, expansion and regeneration Leptin Engages a Hypothalamic Neurocircuitry to Permit 9/9/13 Jillian Varonin Survival in the Absence of Insulin Megan Adipocyte Lipid Chaperone aP2 Is a Secreted Adipokine 8/26/13 Robblee Regulating Hepatic Glucose Production Melanocortin 4 Receptors Reciprocally Regulate 8/19/13 James Warne Sympathetic and Parasympathetic Preganglionic Neurons Neonatal leptin exposure specifies innervation of 8/12/13 Allison Xu presympathetic hypothalamic neurons and improves the metabolic status of leptin-deficient mice Hypothalamic programming of systemic ageing involving **8/7/13** Ivan Rudenko IKK-β, NF-κB and GnRH Omega-3 Fatty Acids Prevent Inflammation and 7/22/13 Suneil Koliwad Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation Rare variants in single-minded 1 (SIM1) are associated 7/15/13 Yi Wang with severe obesity Stephanie Van 7/8/13 A guide to analysis of mouse energy metabolism Veen 7/1/13 Kosaku Betatrophin: A Hormone that Controls Pancreatic β Cell Shinoda Proliferation MetaboRIPS: Xin Chen Lab and Miyuki Suzawa (Ingraham 6/24/13 MetaboRIPS Lab) (Gladstone Rm C&D) Angiotensin-converting enzyme inhibition reduces food 6/17/13 Paula Jossan intake and weight gain and improves glucose tolerance in melanocortin-4 receptor deficient female rats Martin Gene silencing in adipose tissue macrophages regulates 6/10/13 Valdearcos whole-body metabolism in obese mice Contreras EBF2 Determines and Maintains Brown Adipocyte 6/3/13 Linet Mera Identity Acute and long-term suppression of feeding behavior by 5/20/13 Bill Krause POMC neurons in the brainstem and hypothalamus, respectively Neurotransmitter Switching in the Adult Brain Regulates 5/13/13 Shi-Bing Yang Behavior Bi-directional interconversion of brite and white 5/6/13 Si Sonne adipocytes 4/29/13 No JC Diabetes Center Retreat MetaboRIPS: Masako Asahina (Ashrafi Lab) and Ari 4/22/13 MetaboRIPS Molofsky (Locksley Lab) (CVRI SC159) Fgf10-Expressing Tanycytes Add New Neurons to the Ernie 4/15/13 Appetite/Energy-Balance Regulating Centers of the Yulyaningsih Postnatal and Adult Hypothalamus Leptin regulates glutamate and glucose transporters in 4/8/13 Allison Xu hypothalamic astrocytes Jess Porter Conserved Shifts in the Gut Microbiota Due to Gastric 4/1/13 Abate Bypass Reduce Host Weight and Adiposity MetaboRIPS: Kosaku Shinoda (Kajimura Lab) (Gladstone 3/25/13 MetaboRIPS Rm.C&D) Inhibition of Leptin Regulation of Parasympathetic 3/11/13 Jillian Varonin Signaling as a Cause of Extreme Body Weight- Associated Asthma TRPV4 Is a Regulator of Adipose Oxidative Metabolism, 3/4/13 Kana Ohyama Inflammation, and Energy Homeostasis MetaboRIPS: Camella Wilson (E Weiss Lab) and Aras Mattis 2/25/13 MetaboRIPS (Willenbring Lab) in HSW1128 Targeted estrogen delivery reverses the metabolic 2/11/13 James Warne syndrome Ablation of TRIP-Br2, a regulator of fat lipolysis, Megan 1/14/13 thermogenesis and oxidative metabolism, prevents diet- Robblee induced obesity and insulin resistance 1/7/13 Christophe Ablation of Sim1 neurons causes obesity through Paillart hyperphagia and reduced energy expenditure 12/17/12 MetaboRIPS MetaboRIPS: Catie Gleason (Pearce) and Atabai Lab Polysome Profiling in Liver Identifies Dynamic 12/10/12 Suneil Koliwad Regulation of Endoplasmic Reticulum Translatome by Obesity and Fasting 11/26/12 MetaboRIPS MetaboRIPS: James Warne (Xu) and Jonas Sjolund (Balmain) PTEN Loss in the Myf5 Lineage Redistributes Body Fat 11/19/12 Haruya Ono and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors 11/5/12 Jamila Newton Neuropeptide Transmission in Brain Circuits MetaboRIPS: Louise Olofsson (Xu) and JP Upton (Oakes) in 10/29/12 MetaboRIPS N-225 Stephanie Van The Number of X Chromosomes Causes Sex 10/22/12 Veen Differences in Adiposity in Mice Jess Porter Antibiotics in early life alter the murine colonic 10/15/12 Abate microbiome and adiposity Protein Modularity, Cooperative Binding, and Hybrid 10/1/12 Linet Mera Regulatory States Underlie Transcriptional Network Diversification IKKβ/NF-κB disrupts adult hypothalamic neural stem 9/24/12 Ivan Rudenko cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes Metabolism Research in Progress Series: Yong Pan (Verdin 09/17/12 MetaboRIPS Lab) Kosaku Temporal coding of insulin action through multiplexing of 9/10/12 Shinoda the AKT pathway Leptin action through hypothalamic nitric oxide 8/27/12 James Warne synthase-1–expressing neurons controls energy balance 8/20/12 Shi-Bing Yang Deconstruction of a neural circuit for hunger Martin Time-Restricted Feeding without Reducing Caloric 8/13/12 Valdearcos Intake Prevents Metabolic Diseases in Mice Fed a High- Contreras Fat Diet. Christophe Melanocortin-4 receptor signaling is required for weight 8/6/12 Paillart loss after gastric bypass surgery Shingo Complement C1q Activates Canonical Wnt Signaling 7/23/12 Kajimura and Promotes Aging-Related Phenotypes Hyperresponsivity to Low-Dose Endotoxin during Megan 7/16/12 Progression to Nonalcoholic Steatohepatitis Is Robblee Regulated by Leptin-Mediated Signaling Daniele Enteric glia are multipotent in culture but primarily form 7/9/12 Rottkamp glia in the adult rodent gut A PGC1-α-dependent myokine that drives brown-fat-like 7/2/12 Louis Sharp development of white fat and thermogenesis FoxO1 Target Gpr17 Activates AgRP Neurons to 6/25/12 Yi Wang Regulate Food Intake Ernie Involvement of Doublecortin-Expressing Cells in the 6/18/12 Yulyaningsih Arcuate Nucleus in Body Weight Regulation Hypothalamic Neuropeptide Y (NPY) Controls Hepatic 6/04/12 Sofie Nielsen VLDL-Triglyceride Secretion in Rats via the Sympathetic Nervous System Fasting Activation of AgRP Neurons Requires NMDA 05/14/12 Ivan Rudenko Receptors and Involves Spinogenesis and Increased Excitatory Tone IRS2 Signaling in LepR-b Neurons Suppresses FoxO1 05/07/12 Jillian Varonin to Control Energy Balance Independently of Leptin Action Kosaku Pten Positively Regulates Brown Adipose Function, 04/30/12 Shinoda Energy Expenditure, and Longevity Rapamycin-Induced Insulin Resistance Is Mediated by 04/23/12 James Warne mTORC2 Loss and Uncoupled from Longevity Regulation of GABA and Glutamate Release from 04/16/12 Shi-Bing Yang Proopiomelanocortin Neuron Terminals in Intact Hypothalamic Networks Tanycytes of the hypothalamic median eminence form a 04/02/12 Jamila Newton diet-responsive neurogenic niche Daniele Direct leptin action on POMC neurons regulates glucose 03/19/12 Rottkamp homeostasis and hepatic insulin sensitivity in mice Shingo Fibroblast Growth Factor-21 Regulates PPARγ Activity 03/05/12 Kajimura and the Antidiabetic Actions of Thiazolidinediones Megan Dysfunction of lipid sensor GPR120 leads to obesity in 02/27/12 Robblee both mouse and human Distinct Roles for Specific Leptin Receptor Signals in the 02/13/12 Sofie Nielsen Development of Hypothalamic Feeding Circuits Martin Autophagy in Hypothalamic AgRP Neurons Regulates 02/06/12 Contreras Food Intake and Energy Balance Clement Remodeling of the arcuate nucleus energy-balance 01/23/12 Cheung circuit is inhibited in obese mice 01/16/12 No Meeting MLK day Obesity is associated with hypothalamic injury in rodents 01/09/12 Suneil Koliwad and humans NPY and MC4R Signaling Regulate Thyroid Hormone 12/19/11 Yi Wang Levels during Fasting through Both Central and Peripheral Pathways Adipocyte NCoR Knockout Decreases PPARγ 12/12/11 Haruya Ono Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity Transplanted Hypothalamic Neurons Restore Leptin 12/05/11 Ivan Rudenko Signaling and Ameliorate Obesity in db/db Mice Kosaku Dynamics of human adipose lipid turnover in health and 11/28/11 Shinoda metabolic diseases 11/21/11 Jamila Newton SfN review Jess Porter Eosinophils Sustain Adipose Alternatively Activated 11/14/11 Abate Macrophages Associated with Glucose Homeostasis Neuropeptide Y and Agouti-Related Peptide Mediate 11/07/11 Allison Xu Complementary Functions of Hyperphagia and Reduced Energy Expenditure in Leptin Receptor Deficiency Stephanie Van Distinct Hypothalamic Neurons Mediate Estrogenic 10/31/11 Veen Effects on Energy Homeostasis and Reproduction 10/24/11 No Meeting Diabetes Center Retreat Nicotine Decreases Food Intake Through Activation of 10/17/11 James Warne POMC Neurons Hunger States Switch a Flip-Flop Memory Circuit via a 10/03/11 Shi-Bing Yang Synaptic AMPK-Dependent Positive Feedback Loop 10/10/11 No Meeting Columbus Day Peroxisome proliferation-associated control of reactive Louise 09/26/11 oxygen species sets melanocortin tone and feeding in Olofsson diet-induced obesity Christophe Leptin Action via Neurotensin Neurons Controls Orexin, 09/19/11 Paillart the Mesolimbic Dopamine System and Energy Balance An ADIOL-ERβ-CtBP Transrepression Pathway 09/12/11 Suneil Koliwad Negatively Regulates Microglia-Mediated Inflammation 09/05/11 No Meeting Labor Day Desnutrin/ATGL Is Regulated by AMPK and Is Required 08/29/11 Haruya Ono for a Brown Adipose Phenotype Rats Moderate Long-Term Modulation of Neuropeptide Y in 08/22/11 Yi Wang Hypothalamic Arcuate Nucleus Induces Energy Balance Alterations in Adult Rats Shingo Protection from Obesity and Diabetes by Blockade of 08/15/11 Kajimura TGF-β/Smad3 Signaling Proliferative Hypothalamic Neurospheres Express NPY, 08/01/11 Ivan Rudenko AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons Knockdown of NPY Expression in the Dorsomedial 07/18/11 Allison Xu Hypothalamus Promotes Development of Brown Adipocytes and Prevents Diet-Induced Obesity High-fat feeding promotes obesity via insulin 07/11/11 Shi-Bing Yang receptor/PI3K-dependent inhibition of SF-1 VMH neurons 06/27/11 Jamila Newton Endo Conference review 06/20/11 James Warne Endo Conference review Concepts and Controversies in Scaling Metabolic Rate: What 06/13/11 Andrew Pierce Can We Do? Role of Hypothalamic Melanocortin System in Christophe 05/23/11 Adaptation of Food Intake to Food Protein Increase in Paillart Mice Louise Rapid, reversible activation of AgRP neurons drives 05/16/11 Olofsson feeding behavior in mice Genetic rescue of nonclassical ERα signaling Clement 05/09/11 normalizes energy balance in obese Erα-null mutant Cheung mice Differential Distribution of Tight Junction Proteins 05/02/11 Ivan Rudenko Suggests a Role for Tanycytes in Blood-Hypothalamus Barrier Regulation in the Adult Mouse Brain Role of Ucp1 enhancer methylation and chromatin 04/18/11 MeeJ Kim remodelling in the control of Ucp1 expression in murine adipose tissue Abrogation of growth hormone secretion rescues fatty 04/11/11 Andrew Pierce liver in mice with hepatocyte-specific deletion of JAK2 Early-Life Exposure to Testosterone Programs the 04/04/11 Jamila Newton Hypothalamic Melanocortin System Long-range gene regulation links genomic type 2 03/28/11 Nadav Ahituv diabetes and obesity risk regions to HHEX, SOX4, and IRX3 Simultaneous POMC gene transfer to hypothalamus and Christophe 03/21/11 brainstem increases physical activity, lipolysis and Paillart reduces adult-onset obesity. Brain insulin controls adipose tissue lipolysis and 03/07/11 James Warne lipogenesis AGRP neurons are sufficient to orchestrate feeding 02/07/11 Shi-Bing Yang behavior rapidly and without training Activation of Central, But Not Peripheral, Estrogen Receptors Is Necessary for Estradiol’s Anorexigenic Clement Effect in Ovariectomized Rats & Intrauterine Position 01/31/11 Cheung Affects Estrogen Receptor {alpha} Expression in the Ventromedial Nucleus of the Hypothalamus via Promoter DNA Methylation Louise Deficiency of lipoprotein lipase in neurons modifies the 01/24/11 Olofsson regulation of energy balance and leads to obesity 01/10/11 Andrew Pierce CRTC3 links catecholamine signalling to energy balance 12/13/10 Jamila Newton Neuroscience meeting review Leptin Rapidly Improves Glucose Homeostasis in Obese 12/06/10 Shi-Bing Yang Mice by Increasing Hypothalamic Insulin Sensitivity Diet-induced obesity in zebrafish shares common 11/29/10 Nadav Ahituv pathophysiological pathways with mammalian obesity Christophe Lack of leptin activity in blood samples of Adélie penguin 11/08/10 Paillart and bar-tailed godwit Postnatal Sim1 Deficiency Causes Hyperphagic Obesity 11/01/10 MeeJ Kim and Reduced Mc4r and Oxytocin Expression Disruption of hypothalamic leptin signaling in mice leads Louise 10/25/10 to early-onset obesity, but physiological adaptations in Olofsson mature animals stabilize adiposity levels SIRT1 Deacetylase in POMC Neurons Is Required for 10/18/10 Ivan Rudenko Homeostatic Defenses against Diet-Induced Obesity Rai1 haploinsufficiency causes reduced Bdnf expression resulting in hyperphagia, obesity and altered fat 10/11/10 Melissa Meucci distribution in mice and humans with no evidence of metabolic syndrome. Interleukin-6 signaling in liver-parenchymal cells 10/04/10 James Warne suppresses hepatic inflammation and improves systemic insulin action Clement Hypothalamic AMPK and fatty acid metabolism mediate 09/27/10 Cheung thyroid regulation of energy balance A sensitive period for environmental regulation of eating 09/20/10 Hélène Favre behavior and leptin sensitivity Agrp Neurons Mediate Sirt1's Action on the 09/13/10 Jamila Newton Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity Synaptic input organization of the melanocortin system 08/16/10 Allison Xu predicts diet-induced hypothalamic reactive gliosis and obesity Kisspeptin Directly Excites Anorexigenic Louise Proopiomelanocortin Neurons but Inhibits Orexigenic 08/09/10 Olofsson Neuropeptide Y Cells by an Indirect Synaptic Mechanism Hyperleptinemia Is Required for the Development of 08/02/10 Andrew Pierce Leptin Resistance Melanocortin signaling in the CNS directly regulates 07/26/10 James Warne circulating cholesterol Neurogenesis in the ependymal layer of the adult rat 3rd 07/19/10 Ivan Rudenko ventricle Cyclooxygenase-2 Controls Energy Homeostasis in 07/12/10 Ritu Malhotra Mice by de Novo Recruitment of Brown Adipocytes Signaling through Tyr985 of Leptin Receptor as an 06/21/10 Melissa Meucci Age/Diet-Dependent Switch in the Regulation of Energy Balance Dopamine D2 receptors in addiction-like reward 06/14/10 Shi-Bing Yang dysfunction and compulsive eating in obese rats Thyroid hormone exerts negative feedback on 06/07/10 Hélène Favre hypothalamic type 4 melanocortin receptor expression Clement Pomc-expressing progenitors give rise to antagonistic 05/24/10 Cheung neuronal populations in hypothalamic feeding circuits Christophe Cholecystokinin Knockout Mice Are Resistant to High- 05/17/10 Paillart Fat Diet-Induced Obesity The Action of Leptin on Appetite-Regulating Cells in the 05/03/10 Jen Wade Ovine Hypothalamus: Demonstration of Direct Action in the Absence of the Arcuate Nucleus Segregation of Acute Leptin and Insulin Effects in 04/19/10 Jamila Newton Distinct Populations of Arcuate Proopiomelanocortin Neurons Identification of neuronal subpopulations that project Louise 04/12/10 from hypothalamus to both liver and adipose tissue Olofsson polysynaptically 04/05/10 Ivy Aslan Leptin therapy in insulin-deficient type I diabetes Double-Stranded RNA-Dependent Protein Kinase Links 03/29/10 Andrew Pierce Pathogen Sensing with Stress and Metabolic Homeostasis Divergent Regulation of Energy Expenditure and Hepatic 03/22/10 James Warne Glucose Production by Insulin Receptor in Agouti- Related Protein and POMC Neurons PTP1B and SHP2 in POMC neurons reciprocally 03/15/10 Ivan Rudenko regulate energy balance in mice Inma Valle Role of the hypothalamic-pituitary-thyroid axis in 03/08/10 Asencio metabolic regulation by JNK1 Critical Role of Arcuate Y4 Receptors and the 03/01/10 Hélène Favre Melanocortin System in Pancreatic Polypeptide-Induced Reduction in Food Intake in Mice Hypothalamic-Specific Manipulation of Fto , the Ortholog 02/22/10 Melissa Meucci of the Human Obesity Gene FTO , Affects Food Intake in Rats Synchronized Network Oscillations in Rat 02/08/10 Shi-Bing Yang Tuberoinfundibular Dopamine Neurons: Switch to Tonic Discharge by Thyrotropin-Releasing Hormone Autophagy regulates adipose mass and differentiation in 02/01/10 Ritu Malhotra mice 01/11/10 Jamila Newton Trophic effects of leptin Clement Regulation of adaptive behaviour during fasting by 01/04/10 Cheung hypothalamic Foxa2 +supplement 12/14/09 Louise The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons Olofsson with regulation of food intake & supplement Molecular therapy of obesity and diabetes by a 11/30/09 Andrew Pierce physiological autoregulatory approach Proopiomelanocortin Expression in both GABA and 11/23/09 Ivan Rudenko Glutamate Neurons Dominant role of the p110beta isoform of PI3K over 11/16/09 James Warne p110alpha in energy homeostasis regulation by POMC and AgRP neurons + supplemental data Modulation of Blood Pressure by Central 11/02/09 Ivy Aslan Melanocortinergic Pathways Jacqueline 10/26/09 Adult Type 3 Adenylyl CyclaseDeficient Mice Are Obese Siljee Palmitic acid mediates hypothalamic insulin resistance 10/19/09 Jen Wade by altering PKC-θ subcellular localization in rodents Neuronal Protein Tyrosine Phosphatase 1B Deficiency Inma Valle 10/05/09 Results in Inhibition of Hypothalamic AMPK and Isoform- Asencio Specific Activation of AMPK in Peripheral Tissues 09/21/09 Hélène Favre Inactivation of the Fto gene protects from obesity FoxO1 inhibits leptin regulation of pro-opiomelanocortin 09/14/09 Melissa Meucci promoter activity by blocking STAT3 interaction with specificity protein 1 White Adipose Tissue Cells Are Recruited by 08/31/09 Baran Ersoy Experimental Tumors and Promote Cancer Progression in Mouse Models Louise Loss of GABAergic Signaling by AgRP Neurons to the 08/24/09 Olofsson Parabrachial Nucleus Leads to Starvation Leptin Acts via Leptin Receptor-Expressing Lateral Clement 08/17/09 Hypothalamic Neurons to Modulate the Mesolimbic Cheung Dopamine System and Suppress Feeding Cold-activated Brown Adipose Tissue in Healthy Men 08/10/09 Shi-Bing Yang Identification and Importance of Brown Adipose Tissue in Adult Humans High-Fat Diet Induces Apoptosis of Hypothalamic 08/03/09 Andrew Pierce Neurons Regulation of Pancreatic β Cell Mass by Neuronal 07/27/09 Allison Xu Signals from the Liver Leptin-Dependent Control of Glucose Balance and 07/20/09 Ivan Rudenko Locomotor Activity by POMC Neurons 07/13/09 Jamila Newton Endo meeting review 06/22/09 James Warne ADA meeting review 06/15/09 Jacqueline Central Nervous System Imprinting of the G Protein Gsα Siljee and Its Role in Metabolic Regulation 5-HT inhibition of rat insulin 2 promoter Cre recombinase 06/01/09 Jamila Newton transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus 05/18/09 James Warne Leptin Targets in the Mouse Brain Hindbrain Leptin Stimulation Induces Anorexia and Christian 05/11/09 Hyperthermia Mediated by Hindbrain Melanocortin Vaisse Receptors Loss of Hypothalamic Response to Leptin During 05/04/09 Hélène Favre Pregnancy Associated with Development of Melanocortin Resistance MRAP and MRAP2 are bidirectional regulators of the 04/27/09 Melissa Meucci melanocortin receptor family Obesity induces functional astrocytic leptin receptors in 04/20/09 Woo-ping Ge hypothalamus Neuromedin B and Gastrin-Releasing Peptide Excite Arcuate Nucleus Neuropeptide Y Neurons in a Novel 04/13/09 Florence Lee Transgenic Mouse Expressing Strong Renilla Green Fluorescent Protein in NPY Neurons Inma Valle Differential Responses of Orexigenic Neuropeptides to 04/06/09 Asencio Fasting in Offspring of Obese Mothers Intestinal Gluconeogenesis Is a Key Factor for Early 03/23/09 Ivy Aslan Metabolic Changes after Gastric Bypass but Not after Gastric Lap-Band in Mice A Mathematical Model of Murine Metabolic Regulation 03/03/09 Shi-Bing Yang by Leptin: Energy Balance and Defense of a Stable Body Weight Requirement of Bardet-Biedl Syndrome Proteins for 02/23/09 Baran Ersoy Leptin Receptor Signaling Endoplasmic Reticulum Stress Plays a Central Role in 02/09/09 Andrew Pierce Development of Leptin Resistance + supplement Jacqueline 02/02/09 Keystone meeting review Siljee Maternal High-Fat Diet and Fetal Programming: Clement Increased Proliferation of Hypothalamic Peptide- 01/26/09 Cheung Producing Neurons That Increase Risk for Overeating and Obesity Regulation of Feeding and Metabolism by Neuronal and 01/12/09 Jen Wade Peripheral Clocks in Drosophila + Supplement Evidence for defective mesolimbic dopamine exocytosis 01/05/09 Jamila Newton in obesity-prone rats 12/15/08 James Warne PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response A Stress Signaling Pathway in Adipose Tissue 12/08/08 Liz Unger Regulates Hepatic Insulin Resistance + Supplement Ablation of CD11c-positive cells normalizes insulin 12/01/08 Andrew Pierce sensitivity in obese insulin resistant animals Jacqueline b-Arrestin–Mediated Localization of Smoothened to the 11/24/08 Siljee Primary Cilium +Supplemental data Louise Ablation of estrogen receptor alpha (ERα) prevents 11/17/08 Olofsson upregulation of POMC by leptin and insulin Overexpression of CART in the PVN Increases Food 10/27/08 Sandy Do Intake and Weight Gain in Rats Synaptic release of GABA by AgRP neurons is required 11/03/08 Melissa Meucci for normal regulation of energy balance Evidence for Constitutive Neural Cell Proliferation in the 10/20/08 Hélène Favre Adult Murine Hypothalamus A FLEX Switch Targets Channelrhodopsin-2 to Multiple 10/13/08 Woo-Ping Ge Cell Types for Imaging and Long-Range Circuit Mapping Hypothalamic IKKb/NF-kB and ER Stress Link 10/06/08 Allison Xu Overnutrition to Energy Imbalance and Obesity + Supplemental Inma Valle Brain-specific carnitine palmitoyl-transferase-1c: role in 09/29/08 Asencio CNS fatty acid metabolism, food intake, and body weight UCP2 mediates ghrelin's action on NPY/AgRP neurons 09/22/08 Shi-Bing Yang by lowering free radicals Selective inactivation of Socs3 in SF1 neurons improves 09/15/08 Florence Lee glucose homeostasis without affecting body weight New role of bone morphogenetic protein 7 in brown 09/08/08 Baran Ersoy adipogenesis and energy expenditure + Supplement Imaging structure and function in the CNS (Cold Spring 08/25/08 Jamila Newton Harbor) Resveratrol Delays Age-Related Deterioration and Sayali 08/18/08 Mimics Transcriptional Aspects of Dietary Restriction Ranadive without Extending Life Span Starvation after AgRP neuron ablation is independent of 08/11/08 Jen Wade melanocortin signaling Chrisitan Leptin reverses weight loss–induced changes in regional 08/04/08 Vaisse neural activity responses to visual food stimuli Upper intestinal lipids trigger a gut-brain-liver axis to 07/28/08 James Warne regulate glucose production + Supplementary Information Regulation of AgRP mRNA transcription and peptide 07/21/08 Liz Unger secretion by acute and chronic inflammation 07/14/08 Louise Leptin controls adipose tissue lipogenesis via central, Olofsson STAT3–independent mechanisms Agouti-Related Peptide and MC3/4 Receptor Agonists Clement 07/07/08 Both Inhibit Excitatory Hypothalamic Ventromedial Cheung Nucleus Neurons Silencing of estrogen receptor alpha in the ventromedial 06/30/08 Andrew Pierce nucleus of hypothalamus leads to metabolic syndrome Various 06/23/08 ADA / Endo meeting summaries presenters Inma Valle TrkB Agonists Ameliorate Obesity and Associated 05/19/08 Asencio Metabolic Conditions in Mice Oxytocin deficiency mediates hyperphagic obesity of 05/12/08 Sandy Do Sim1 haploinsufficient mice Acute effects of leptin require PI3K signaling in 05/05/08 Florence Lee hypothalamic proopiomelanocortin neurons in mice Leptin promotes adult hippocampal neurogenesis in vivo 04/29/08 Melissa Meucci and in vitro Activation of Stat3 Signaling in AgRP Neurons Promotes Locomotor Activity 04/22/08 Baran Ersoy Stat3 is required in hypothalamic Agrp/Npy neurons for normal energy homeostasis Bardet–Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary Jacqueline 04/15/08 cilia Siljee Identification of Ciliary Localization Sequences within the Third Intracellular Loop of G Protein-Coupled Receptors Serotonin 5-HT2C Receptor Agonist Promotes 04/08/08 Jamila Newton Hypophagia via Downstream Activation of Melanocortin 4 Receptors Obesity and Hypertriglyceridemia Produce Cognitive 04/01/08 Andrew Pierce Impairment Disruption of leptin receptor expression in the pancreas 03/25/08 Allison Xu directly affects β cell growth and function in mice PYY modulation of cortical and hypothalamic brain areas 03/17/08 Ali Reed predicts feeding behaviour in humans + Supplementary information + Background materials Christian Disruption of the RIIβ subunit of PKA reverses the 03/11/08 Vaisse obesity syndrome of agouti lethal yellow mice The Acyclic CB1R Inverse Agonist Taranabant Mediates Weight Loss by Increasing Energy Expenditure and Decreasing Caloric Intake 03/04/08 Jen Wade Background material: Endocannabinoids and related N- acylethanolamines in the control of appetite and energy metabolism: emergence of new molecular players Christian 02/28/08 Vaisse, Allison Keystone meeting review Xu et al. Enhanced Leptin-Stimulated Pi3k Activation in the CNS 02/13/08 James Warne Promotes White Adipose Tissue Transdifferentiation + Supplemental Data The central melanocortin system directly controls 02/05/08 Liz Unger peripheral lipid metabolism+ Supplimentary Material Targeted Deletion of AIF Decreases Mitochondrial Inma Valle 01/29/08 Oxidative Phosphorylation and Protects from Obesity Asencio and Diabetes Tumor-induced anorexia and weight loss are mediated 01/14/08 Sandy Do by the TGF- beta superfamily cytokine MIC-1 Developmental Switch in Neuropeptide Y and 01/07/08 Melissa Meucci Melanocortin Effects in the Paraventricular Nucleus of the Hypothalamus Silencing of OB-RGRP in mouse hypothalamic arcuate 12/11/07 Baran Ersoy nucleus increases leptin receptor signaling and prevents diet-induced obesity Melanocortin-4 Receptor Activation Stimulates Jacqueline Hypothalamic Brain-Derived Neurotrophic Factor 12/17/07 Siljee Release to Regulate Food Intake, Body Temperature and Cardiovascular Function 11/19/07 Jamila Newton SfN meeting review - Topics on neuroscience imaging SfN meeting review - Topics on neuroendocrine regulation of 11/13/07 Andrew Pierce energy balance Endocrine Regulation of Energy Metabolism by the 10/29/07 Jamila Newton Skeleton Disruption of Intraflagellar Transport in Adult Mice Leads Christian 10/01/07 to Obesity and Slow-Onset Cystic Kidney Vaisse Disease + supplemental data Hyperphagia and Early Onset Obesity due to a Novel Sayali 09/17/07 Homozygous Missense Mutation in Prohormone Ranadive Convertase 1/3 08/27/07 Jennifer Wade Creation of a genetic model of obesity in a teleost TLR4 links innate immunity and fatty acid-induced 08/13/07 Andrew Pierce insulin resistance Role of hepatic STAT3 in brain-insulin action on hepatic 07/23/07 Ali Reed glucose production Insulin Action in AgRP-Expressing Neurons Is Required 07/09/07 Allison Xu for Suppression of Hepatic Glucose Production 06/25/07 Inma Valle Chemical chaperones reduce ER stress and restore Asencio glucose homeostasis in a mouse model of type 2 diabetes 06/11/07 Liz Unger Hypothalamic resistin induces hepatic insulin resistance Deorphanization of a G protein-coupled receptor for 05/29/07 Baran Ersoy oleoylethanolamide and its use in the discovery of small molecule hypophagic agents A Key Role of Leptin in the Control of Regulatory T Cell 05/07/07 Gabe Loeb Proliferation A Central Thermogenic-like Mechanism in Feeding Jacqueline 03/19/07 Regulation: An Interplay between Arcuate Nucleus T3 Siljee and UCP2 Anorectic estrogen mimics leptin's effect on the rewiring 03/26/07 Melissa Meucci of melanocortin cells and Stat3 signaling in obese animals Altered Expression of SOCS3 in the Hypothalamic 02/12/07 Andrew Pierce Arcuate Nucleus during Seasonal Body Mass Changes in the Field Vole, Microtus agrestis Sayali Role of the Central Melanocortin Circuitry in Adaptive 01/22/07 Ranadive Thermogenesis of Brown Adipose Tissue A brain-specific microRNA regulates dendritic spine 01/08/07 Hélène Favre development Modulation of neuropeptide Y expression in adult mice 12/11/06 Allison Xu does not affect feeding miR-7b, a microRNA up-regulated in the hypothalamus 10/30/06 Noelle Huskey after chronic hyperosmolar stimulation, inhibits Fos translation Enhanced leptin sensitivity and improved glucose 09/24/06 Andrew Pierce homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells Christian Serotonin reciprocally regulates melanocortin neurons to 08/28/06 Vaisse modulate food intake 08/07/06 Baran Ersoy Vaccination against weight gain Overfeeding in identical twins: 5-year postoverfeeding 07/24/06 Melissa Meucci results 07/10/06 Simone Tchu Hypothalamic mTOR signaling regulates food intake Low-dose leptin reverses skeletal muscle, autonomic, 06/05/06 Gabe Loeb and neuroendocrine adaptations to maintenance of reduced weight Forkhead protein FoxO1 mediates Agrp-dependent 05/22/06 Hélène Favre effects of leptin on food intake Reactive oxygen species have a causal role in multiple 05/08/06 Merisa Piper forms of insulin resistance 04/10/06 Noelle Huskey Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus Ghrelin controls hippocampal spine synapse density and 03/27/06 Mehdi Skhiri memory performance