DOCSLIB.ORG

ASMS Conference on Mass Spectrometry and Allied Topics

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
ASMS Conference on Mass Spectrometry and Allied Topics X 00 as*03 0> AS AJ Proceedings CD The 46th ASMS Conference on Mass Spectrometry and Allied Topics May 31-June 4,1998 Orlando, Florida The 46* ASMS CONFERENCE ON TUESDAY ORALS MASS SPECTROMETRY AND ALLIED TOPICS Non-Covalent Interactions & Tertiary Structures of Biomolecues 379 May 31 - June 4,1998 Glycobiology 391 Ion Structures & Energetics 403 TABLE OF CONTENTS Mass Spectrometry in a DNA World 411 Electrospray Fundamentals & Instrumentation 423 Foreword and Citation Notice n Miniaturizing Mass Spectrometers 434 ASMS Board of Directors in Micro Sample Preparation Methods 436 Program Acknowledgments m Interest Group Coordinators iv TUESDAY POSTERS ASMS Committees iv Fundamental Studies I 441 ASMS Awards iv Trapped Ions 470 ASMS Corporate Members v LC/MS (Separations) 520 TITLES OF EXTENDED ABSTRACTS LISTED BY SESSION vil Proteins & Peptides II 585 Title information appears as it was submitted by authors on diskette Lipids Hormones and Biomarkers 644 Separabons/MALDI 672 MONDAY ORALS Drug Metabolism Qualitative 683 Environmental II 725 Analysis of Biomolecules by Electrospray & MALDI 1 Applications Ionization - 659 MS in Pharmacology and Toxicology 12 Spray Applications Reactions of Gas Phase Ions 22 Drug Metabolism - Quantitative 689 Innovations in TOF & Hybnd TOF Instrumentation 33 WEDNESDAY ORALS FTMS Fundamentals and kApplications 44 New Developments & Applications of Inorganic Mass Spectrometry 54 Emerging Methods in Biological Mass Spectrometry 757 Isotope Ratio & Elemental Mass Spectrometry 59 Electrospray and MALDI of Small Molecules 768 Coming of Age Twenty-one Years of the Kinetic Method 780 MONDAY POSTERS MALDI Design and Fundamentals 790 MALDI at Other 796 Special Posters 64 Wavelengths MS of DNA Adducts & Ion Activation and Dissociation 67 Interactions 802 and Petrochemicals 810 Computer Applications 110 Energy Automation & Methods 815 Spray Ionization - Fundamentals 131 Computer Laser Desorption Applications I 154 WEDNESDAY POSTERS Proteins & Peptides I 183 DNA & RNA Structures and Adducts 243 Ion-Molecule Reactions 820 Clinical Applications I 283 MS Instrumentation Ion Sources 880 C |i Isotope Ratios Inorganic and Elemental Analysis 323 Laser Desorption (Fundamentals) 919 |°° 3 QA/QC Process Monitoring 334 Proteins and Peptides 111 942 §-& ^ Environmental Analyses I 339 Laser Desorption (Applications) 998 Combinatorial Chemistry 1028 Polymers Surfactants and Petrochemicals 1052 Clinical Applications 1090 Toxicology 1121 THURSDAY ORALS FOREWORD Mass Spectrometry & Combinatonal Chemistry 1139 Innovations in Methods Combined with MS 1150 This Separations volume represents the official record of the annual meeting and is designated as the Pro¬ Environmental Mass Spectrometry 1162 ceedings of the 46th ASMS Conference on Mass Spectrometry and Allied Topics. New Developments in Quadrupole Ion Trap Mass Spectrometry 1172 Mass of 1184 The - Spectrometry Polymers 1998 ASMS Conference was held May 31 June 4, 1998 at the Marriott World Center, Or¬ Mass in Forensics 1195 Flonda. Spectrometry lando, The total number of conference attendees was 2,975 A total of 1,382 posters Mass Spectrometry Detection & Identification of 1201 and 279 oral Microorganisms presentations were given, including four tutorial and four plenary lectures. The included the of the highlights presentation 1998 ASMS Award for Distinguished Contribution in THURSDAY POSTERS Mass Spectrometry jointly to Professor Don C McGilvery of Monash University and Dr David A. Dahl of Idaho National and Environmental Fundamental Studies II 1206 Engineering Laboratory, for the development of the ion MS Instrumentation: SIMION optics design and analysis programs. The 1998 Biemann Medal was presented to Mass Analyzers . .. 1233 Professor Robert R. from Purdue for the of CE Separations with MS 1266 Squires University ingenious application mass spec¬ trometry to the characterization of reactive and intermediates The 1998 Affinity-Based Separations 1287 organic organometallic Research Awards were to Proteins & Peptides IV. 1301 Young Investigator presented Professor Patnck A Limbach of Lou¬ isiana State Professor Wood of Carbohydrates 1363 University (sponsored by Finnigan Corporation), Troy State Uni¬ versity of New York Exxon Education Professor Paul G Spray Ionization (Applications) 1388 (sponsored by Foundation), Wenthold of Texas Tech ASMS and Drug Metabolism (Quantitative) 1422 University (sponsored by Analytica of Branford), Professor George of Simon Fraser PE Separation Methods- GC 1464 Agnes University (sponsored by Sciex), and Professor Mary Theresa Rodgers of State Organic Analysis 1476 Wayne University (sponsored by Micromass) thanks are to Bob WORKSHOPSAND INTEREST GROUP MEETINGS Special given Cotter, Vice-President for Programs, for arranging an excellent and inspiring scientific program, and to Judith A Sjoberg, Cindi Lilly, and the staff of Profes¬ Ion Trap MS 1502 sional Association Management, for coordinating the printing and distribution of the Proceed¬ Surface Science 1503 ings Young Mass Spectrometrists 1504 Metal Ion Coordination 1505 Hilkka I. Kenttamaaa Ionization Desorption 1506 ASMS Board of Directors LC/MS 1507 Member-at-Large (Publications) Analytical Laboratory Managers 1508 History 1509 FTMS 1510 CITATION NOTICE TOF-MS 1511 Fundamentals 1512 This volume contains the Energy and Petrochemicals 1513 extended abstracts of papers presented at the 46lh ASMS Conference on Mass and Allied Quantitation 1514 Spectrometry Topics The material is not copyrighted and appearance of material in this volume does not Biomedical Applications 1515 jeopardize the author's right to publish the information in scien¬ tific journals. MINUTES OF THE ASMS BUSINESS MEETING 1516 Reference to individual abstracts contained in this volume should be cited as follows: of the 46* INDEX OF AUTHORS 1517 Authorfs), Title, Proceedings ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, Florida, May 31 - June 4, 1998. INDEX OF KEY WORDS 1532 MONDAY ORALS MS IN PHARMACOLOGY AND TOXICOLOGY WalterA. Korfmacher, presiding ANALYSIS OF BIOMOLECULES BY ELECTROSPRAY & MALDI Birenda Pramanik and Joseph Zaia, presiding Large Scale Quantitative Analysis of Pharmaceuticals via LC-MS and LC-MS/MS Ion Trap Mass Specrometry; Cole, Mark; *Cunniff, Jack; Drexler, Dieter; Land, interactions and fibril formation studied ESI MS; Nettleton, Protein amyloid by Adrian; Pfizer Pharmaceuticals, Groton CT 12 Ewan; Sunde, Margaret; 'Robinson, Carol; Oxford Center for Molecular Sciences 1 Evaluation of a novel API ion source for the high throughput determination of Nano-ESI and MS"-Structure Elucidation of Neutral Underivatized drugs directly from cell culture media for in-vitro studies., Vayer, Philippe; Castro Oligosaccharides and Glycosides; *Karas, Michael; Bahr, Ute; Schubert-Z., Jose Bertrand Perez, Miguel, McDowall, Mark; 'Preece, Steve; , Marc; Technologie Division of Instrumental 2 Manfred; Jurenitsch, J.; Analytical Chemistry Servier, Department of Drug Metabolism 13 between metallothionein and DNA zinc Metal ion transfer binding finger peptides Simultaneous Analysis of Multiple Drug Mixtures for the Quantitation of In-Vitro Fenselau, Catherine, Structural probed by ESI-MS; 'Hathout, Yetrib; Fabris, Dan; Permeability Through the Caco-2 Model Utilizing LC/MS/MS; *Bulgarelli, James Baltimore 3 Biochemistry Center, University of Maryland County P.; Michael, Steven M.; The DuPont Merck Pharmaceutical Company, Wilmington, DE 14 identification of from human platelets by 2D-polyacrylamide gel phosphoproteins In vitro drug-drug interaction examined by mass spectrometry; 'Chen, Jinchang, and Dorian; Presek, Peter, electrophoresis nanospray ESI-MS/MS; 'Immler, Meyer, Sanchez, Rosa I.; Huskey, Su-Er W.; Karanam, Bindhu V.; Hop, Cornelius E.C.A.; Ruhr-Universitaet 4 Helmut E.; Inst. f. Physiol Chemie I, Bochum, Germany Merck Research Laboratones, Rahway 15 "Krone, Jennifer, R.; Immunoaffinity-Based Quantitative Electrospray Assays, Increasing the Throughput of Microsomal Stability Screening Using Fast Gradient Matthew Lovelace Nelson, Randall, W., Dahl, Alan R.; McLean, A., Respiratory Elution LC/MS; *Ackermann, Bradley; Ruterbories, Kenneth; Hanssen, Brenda; 5 Research Institute Lindstrom, Terry, Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 16 of Disulfide Bond Is Possible in Proteins Assignment Connectivity Containing LC/MS Based Structure Profile Libraries Impact on the Drug-Discovery Continuum, Adjacent Cysteines by Using Cyanylation/Cleavage/Mass Mapping; Yang, Ying; *Rourick, Robyn, A., Fink, Saul, W.; Volk, Kevin, J.; Whitney, Jeffrey, L; Klohr, Steve, Jack Throck; State University 6 Wu, Jiang; *Watson, Michigan E., Kerns, Edward, H.; Lee, Mike, S ; Bristol-Myers Squibb Pharmaceutical Research in Plasma Induced Mass Effects, Polymorphism Apolipoproteins by Spectrometric Institute, Wallingford 17 Texas A&M of Bondarenko, Pavel; *Macfarlane, Ronald; University, Department Metabolism of tirilazad mesylate in humans: Application of stable isotopic Station, TX Chemistry, College labelling and a novel bile cannulation technique in human volunteers; Steenwyk, MALDI-MS of Nucleic Finn, Infrared Large Acids; *Berkenkamp, Stefan; Kirpekar, Rick C; Pearson, Paul G.; "Vrbanac, J. James; Pharmacia and Upjohn, Inc 18 of Hillenkamp, Franz, Institute for Med. Physics and Biophysics, University Muenster, Identification of In Vitro Metabolites by "Intelligent Automated LC-MS/MS" 7 Germany (INTAMS) Utilizing the Finnigan TSQ 7000; Yu, Xiao, Cui, Donghui; "Davis, MALDI of Strategies for
Load more

Recommended publications
  • Recent Progress in Laser Analytics
    KOLUMNE 417 CHIMIA 44 (1990) Nr.I~ (Ikzem""r) Chimia 44 (/990) 417 424 <&') Schll'ei=. Chemiker- Verhand; ISSN 0009 4293 Recent Progress in Laser Analytics Analytical methods are on their way to mass spectrometry (MS). In 1946, William penetrate the biological sciences. In this E. Stephens (University of Pennsylvania in trend, laser technology plays an important Philadelphia) described a mass spectrome- role, especially in the form of laser-desorp- ter with time dispersion, followed by the tion mass spectrometry (LD-MS). ion velocitron of A.E. Cameron and D.£. The remarkable progress made in this Eggers. These devices represented early field is nicely demonstrated by a statement forms of the time-of-flight mass spectrom- made in 1986 by Frank H. Field, a specialist eter (TOF-MS) first described by the Swiss in the mass spectrometric investigation of R. Keller in 1949. biomolecules and Professor at Rockefeller The first commercially successful TOF- University in New York. Citing Professor MS was introduced by Bendix Corpora- In dieser Kalwnne schreibl Field: 'The mass region of real interest for tion, and it was based on the design re- Prof Dr. H. M. Widmer proteins lies between 40000 and 100000 ported in 1955 by William C. Wile)' and Forse/lUng Analylik Da, and one can only speculate as to l. H. McLaren (Bendix Aviation Corpom- Ciha-Geigy AG. FO 3.2 CH 4{)()2 Basel whether such monster gaseos ions could be tion). In these early days of TOF-MS, the regelmiissig eigene Meinungsarlike/ oder liidl Giiste produced. My personal feeling is that to do ions were generated by electron impact ein.
    [Show full text]
  • Nature Milestones Mass Spectrometry October 2015
    October 2015 www.nature.com/milestones/mass-spec MILESTONES Mass Spectrometry Produced with support from: Produced by: Nature Methods, Nature, Nature Biotechnology, Nature Chemical Biology and Nature Protocols MILESTONES Mass Spectrometry MILESTONES COLLECTION 4 Timeline 5 Discovering the power of mass-to-charge (1910 ) NATURE METHODS: COMMENTARY 23 Mass spectrometry in high-throughput 6 Development of ionization methods (1929) proteomics: ready for the big time 7 Isotopes and ancient environments (1939) Tommy Nilsson, Matthias Mann, Ruedi Aebersold, John R Yates III, Amos Bairoch & John J M Bergeron 8 When a velocitron meets a reflectron (1946) 8 Spinning ion trajectories (1949) NATURE: REVIEW Fly out of the traps (1953) 9 28 The biological impact of mass-spectrometry- 10 Breaking down problems (1956) based proteomics 10 Amicable separations (1959) Benjamin F. Cravatt, Gabriel M. Simon & John R. Yates III 11 Solving the primary structure of peptides (1959) 12 A technique to carry a torch for (1961) NATURE: REVIEW 12 The pixelation of mass spectrometry (1962) 38 Metabolic phenotyping in clinical and surgical 13 Conquering carbohydrate complexity (1963) environments Jeremy K. Nicholson, Elaine Holmes, 14 Forming fragments (1966) James M. Kinross, Ara W. Darzi, Zoltan Takats & 14 Seeing the full picture of metabolism (1966) John C. Lindon 15 Electrospray makes molecular elephants fly (1968) 16 Signatures of disease (1975) 16 Reduce complexity by choosing your reactions (1978) 17 Enter the matrix (1985) 18 Dynamic protein structures (1991) 19 Protein discovery goes global (1993) 20 In pursuit of PTMs (1995) 21 Putting the pieces together (1999) CITING THE MILESTONES CONTRIBUTING JOURNALS UK/Europe/ROW (excluding Japan): The Nature Milestones: Mass Spectroscopy supplement has been published as Nature Methods, Nature, Nature Biotechnology, Nature Publishing Group, Subscriptions, a joint project between Nature Methods, Nature, Nature Biotechnology, Nature Chemical Biology and Nature Protocols.
    [Show full text]
  • February 2016
    NEWS AND VIEWS Correspondence to: Gavin E. Reid; e-mail: [email protected] February 2016 Announcements For more information and online registration for any of the conferences listed below, please visit www.asms.org/conferences. 64th ASMS Annual Conference June 5 - 9, 2016 San Antonio, TX www.asms.org/conferences/annual- conference February 5 - Abstract submission deadline April 30 - Advance conference and short course OHIWWRULJKW Professor Simon Gaskell, Professor Perdita Barran and registration deadline Professor Graham Cooks (Purdue University) at the Gaskell symposium dinner held at the Museum of Science and Industry, Manchester, UK. University of Manchester in 2004, he served as Associate Vice The Gaskell Symposium – President for Research, and WKHQ as Vice President IRU 5HVHDUFK IURP WR +H MRLQHG 4XHHQ 0DU\ A Celebration of Mass University of London in October 2009. Spectrometry ,Q D VFLHQWL¿F FDUHHU VSDQQLQJ \HDUV 3URIHVVRU *DVNHOO¶V research involved the development and application of state- A two day meeting was held December 14th and 15th at the University of-the-art mass spectrometry and related analytical techniques, of Manchester, UK, to celebrate the career of Professor Simon ZLWKDSSOLFDWLRQVLQWKHELRPHGLFDOVFLHQFHV+HLVSDUWLFXODUO\ J. Gaskell, President and Principal, and Professor of Biological recognized for his work in developing, along with Professor Vicki Chemistry, at Queen Mary College of London. Organized by Wysocki (Ohio State University), the concept of the ‘mobile Professor Perdita Barran (Chair of Mass
    [Show full text]
  • List of Abbreviations
    Ion Mobility Mass Spectrometry of DNA/SgrAI Nuclease Oligomers Item Type text; Electronic Thesis Authors Ma, Xin Publisher The University of Arizona. Rights Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. Download date 04/10/2021 07:34:14 Link to Item http://hdl.handle.net/10150/247282 ION MOBILITY MASS SPECTROMETRY OF DNA/SGRAI NUCLEASE OLIGOMERS by Xin Ma ________________________ A Thesis Submitted to the Faculty of the DEPARTMENT OF CHEMISTRY AND BIOCHEMISTRY For the Degree of MASTER OF SCIENCE WITH A MAJOR IN CHEMISTRY In the Graduate College THE UNIVERSITY OF ARIZONA 2012 2 STATEMENT BY AUTHOR This Thesis has been submitted in partial fulfillment of requirements for an advanced degree at the University of Arizona and is deposited in the University Library to be made available to borrowers under rules of the library. Brief quotations from this thesis are allowable without special permission, provided that accurate acknowledge of source is made. Requests for permission for extended quotation from or reproduction of in whole or in part may be granted by the head of the major department or the Dean of the Graduate College when in his or her judgment the proposed use of the material is in the interests of scholarship. In all other instances however, permission must be obtained from the author. Signed:______Xin_Ma________ APPROVAL BY THESIS DIRECTOR This thesis has been approved on the date shown below: ____Vicki H.
    [Show full text]
  • Dr Michael Morris Senior Director of Mass Spectrometry Research Waters Corporation, Wilmslow, England
    Dr Michael Morris Senior Director of Mass Spectrometry Research Waters Corporation, Wilmslow, England Institution Degree Year Field of study UMIST, Manchester, UK. B.Sc. 1985 Analytical Chemistry UMIST, Manchester, UK. (Michael Barber) Ph.D 1988 Mass Spectrometry Osaka University, Osaka, Japan. (Takekiyo Study leave 1986 Mass spectrometry Matsuo) Purdue University, West Lafayette, USA. Post-doc 1991 Mass spectrometry (Graham Cooks) NRC, Halifax, Canada. (Bob Boyd) Post-doc 1992 Mass spectrometry Dr Morris received his B.Sc. (Hons) in Analytical Chemistry from UMIST, Manchester in 1985, and a Ph.D. in mass spectrometry from the same institution in 1988 under the supervision of the late Professor Michael Barber FRS. He has been involved in a number of research projects, including the ion optic design of sector instruments, development of surface-induced dissociation and the application of tandem mass spectrometry. He spent time working in Japan (Osaka University), USA (Purdue University) and Canada (National Research Council) before joining Micromass/Waters in 1994. Dr Morris founded the Clinical Operations Group in Waters in 1999, and was responsible for the development of applications of mass spectrometry in neonatal screening, therapeutic drug monitoring and clinical toxicology. This technology is now in wide use around the world for routine clinical chemistry analysis. He rejoined the mass spectrometry research team in 2010. Dr Morris has been the co-organiser of a number of national and international meetings and authored more than 50 publications. He is also a Chartered Chemist and Fellow of the Royal Society of Chemistry (C.Chem., F.R.S.C.). In 2012 he was appointed as a visiting Professor in the Department of Surgery and Cancer at Imperial College, London.
    [Show full text]
  • Dissertation / Doctoral Thesis
    DISSERTATION / DOCTORAL THESIS Titel der Dissertation /Title of the Doctoral Thesis „Proteomic studies on Chlamydomonas reinhardtii“ verfasst von / submitted by Dipl.-Biochem. Luis Recuenco-Muñoz angestrebter akademischer Grad / in partial fulfilment of the requirements for the degree of Doctor of Philosophy (PhD) Wien, 2017 / Vienna 2017 Studienkennzahl lt. Studienblatt / A 794 685 437 degree programme code as it appears on the student record sheet: Dissertationsgebiet lt. Studienblatt / Biologie field of study as it appears on the student record sheet: Betreut von / Supervisors: Univ.-Prof. Dr. Wolfram Weckwerth Ass.-Prof. Dipl.-Biol. Dr. Stefanie Wienkoop, Privatdoz. 2 Declaration of authorship I, Luis Recuenco-Muñoz, declare that this thesis, titled ‘Proteomic studies on Chlamydomonas reinhardtii’ and the work presented in it are my own. I confirm that: • This work was done wholly or mainly while in candidature for a research degree at this University. • Where I have consulted the published work of others, this is always clearly attributed. • Where I have quoted from the work of others, the source is always given. With the exception of such quotations, this thesis is entirely my own work. • I have acknowledged all main sources of help. • Where the thesis is based on work done by myself jointly with others, I have made clear exactly what was done by others and what I have contributed myself. Signed: Date: 3 4 Equal goes it loose (Ernst Goyke) 5 Aknowledgements • I wish to thank Prof. Dr. Wolfram Weckwerth and Dr. habil. Stefanie Wienkoop for giving me the chance to work in this utterly interesting field, tutoring and mentoring me throughout my PhD Thesis, and for all the teaching, support, advice and fun I have had both on a working and on a personal level during my whole stint in Vienna.
    [Show full text]
  • Frank H. Field for the Derelopment and Application of Chemical Ionizalion Mass Spectrometrl
    1996 Award for a Distinguished Contribution in Mass Spectrometry Burnabv llunson and Frank H. Field for the Derelopment and Application of Chemical Ionizalion Mass Spectrometrl The 1996 ASMS Ar,ard for a academic laboratories throughout Distinguished Contribution in the rvorld. Chemical ionization Mass SpectromeLn recognizes a was the first of the "soft focused, singular achier-ement that ionization" techniques. rvhich 'tr,.,li , 'rll'l: significantlv changed the practice have repeatedlv rer-olutionized of mass spectrometn-. The 1996 mass spectrometn. As such. Award will be presented to chemical ionization dramaticallr' Professor Burnabl' Munson. extended the information that University of Delarvare and mass spectrcmetrv could provide Professor Frark Field, Rockefeller and the range of sample materials Burnaby Munson Frank H. Field University', emeritus. on May 16. to rvhich mass spectrometrv could 1996. at this Conference. Professors Munson and Field are be usefully applied. recognized for the development of chemical ionization (CI) This is the seventh ASMS Award for a Distinguished mass spectrometr,v, r.vhich was first described in an article in Contribution in Mass Spectrometry. The awardees rvill the Journal of the Americal Chemical Societr. 88. 2621 receive a cash arvard and a recognition plaque. The au'ard ( 1 966). presentation is 7:30 PM, Thursday followed b-v lectures b1' In the course of their research on ion-molecule reaction Professors Munson and Field. kinetics carried out in the research laboratories of Esso (norv Exron), Professors Field and Murson in 1965 made the first Previous Award Recipients: mass spectrometric verification of the reactions of ions from 1990 Ronald D. Macfarlane, Plasma Desorption lonization methane ll'ith added trace compounds.
    [Show full text]
  • Mass Spectrometry and Protein Structure
    In dian Journal of Bi ochemistry & Bi ophys ics Vo L 39. August 2002. pp. 205-2 16 Minireview Mass spectrometry and protein structure Kapil Maith al' and K Muralidhar2* 'Dr. B R Ambedkar Center for Biomedi cal Research. 2Department of Zoology. Uni ve rsity of Delh i. Delhi 11 0007, India Received 24 April 2002; accepled 6 lillie 2002 Historical Overview ha s led to the usage of cesium (Cs) instead of atom Today's mass spectrometer is based on the seminal gun . wo rk performed by Sir J. J. Thomson of the Another method that all owed analys is of large, Cavendi sh Laboratory (Uni versity of Cambridge), non-volatil e orga nic molecul es was plasma­ whi ch led to the di scovery of the electron in 1897 and desorpti on mass spectrometry (POMS) developed by 5 6 also led to the first mass spectrometer whil e he was Torgerson et al. in 1974 . Wi th the advent of th is measuring the effects of electric and mag neti c fie ld s tec hnique analysis of proteins also became poss ible 7 on ions ge nerated by residual gases in cathode ray and in 1982 first ma ss spectrum of in sulin wa s tubes. Thomson noti ced that the ions move th rough recorded. This was soon foll owed by FAB mass 8 9 pa raboli c trajectori es proporti onal to their "mass-to­ spectra of in sulin . In spite of these ac hievements. charge" rati os. Thomson received the 1906 Nobel both the techniques had maj or limitations, li ke it wa s Pri ze in Phys ics "in recogniti on of the great merits of difficult to ex tend the detecti on mass range beyond 25 his theoreti ca l and experimental in vesti gati ons on the kOa and it was useful for a few ideall y behaved conduct ion of electric ity by gases".
    [Show full text]
  • Mass Spectrometry of Biomolecules: from PDMS to MALDI
    Brazilian Journal of Physics, vol. 29, no. 3, Septemb er, 1999 415 Mass Sp ectrometry of Biomolecules: From PDMS to MALDI Ronald D. Macfarlane Department of Chemistry Texas A&M University Col lege Station, Texas, USA May, 1999 Mother Nature the Ultimate Chemist: South America holds some of the richest rain forests in the world where Nature, through the abundance of the essentials of life has pro duced a rich sp ectrum of biological molecules. The early inhabitants of these regions, over thousands of years, have, through exp erimentation, identi ed plants and animals that contain comp onents that they have found to b e b ene cial for their health or so toxic that they can b e used as a weap on. Poisonous South American tree frogs Do anyofyou knowany examples of drugs or toxins that haveevolved to com- mercial pro ducts that have had their ori- and mass sp ectrometry gin from the exp erience of pre-mo dern history South Americans? When a plant or animal is identi ed as having pan of its chemical make-up, a sp ecies that has imp ortant physiological prop erties, that sp ecies is rst isolated and puri ed. The 3-dimensional chemical structure is While the knowledge of these imp ortant biological elucidated utilizing a variety of sp ectroscopic to ols. The comp ounds was passed on through generations from most information rich of these metho ds are NMR, IR, stories and the practice of medicine by learned mem- and x-ray di raction of pieces of the molecule and the b ers of these native communities, until recently, these whole molecule.
    [Show full text]
  • Michael Karasfor Their Discovery of MALDI
    199- .{WARD FOR A DISTINGUISHED CONTRIBUTION IN MASS SPECTRO}IETRY Franz Hillenkamp and Michael Karasfor their discovery of MALDI The ASMS Award \LA.LDI has revolu- for a Distinguished Con- tionized the anal1'sis of tribution in Mass protehs. peptides and Spectrometry recognizes oligonucleotides. It a focused singular has spa*'ned the devel- achievement in or con- opment of practical and tribution to fundamental efficient new or applied mass spectro- instruments which metry. The 1997 award have been embraced is presented to Professor for use in biological Franz Hillenkamp, and biochemical re- University of Miinster, search. The develop- Franz Hillenkamp and Professor Michael Michael Karas ment of MALDI has Karas, University of tulfilled the long Frankfurt, for their discovery of matrix-assisted laser standing promise of mass spectrometry as a useful tool in the desorption ionization (MALDD. solution of biological problems. It has changed the face of MALDI has fundamentally changed much of the modern biological and macro-molecular mass spectrometry. methodology used in biochemistry, biology, polymer The award will be formally presented at 5:15 pm on chemistry and other areas dealing with large molecules. Thursdav. June 5. 1997 at the 45'h ASMS Conference. Previous Award Recipients 1990 Ronald D. Macfarlane, Plasma Desorption lonization 1994 Donald F. Hunt, I{egative lon Chemical lonization l99l Michael Barber, Fast Atom Bombqrdment lonization 1995 Keith R. Jenniags, Collision Induced Dissociation 1992 John B. Fenn, Electrosproy lonization 1996 Burnaby Munson and Frank Field, Chemical I onizat i on Mas s Snec tr ometrv 1993 Christie G. Enke and Richard A.Yost, Triple Quadrup o le Mas s Sp ec tr omet er THE 1997 BIEMANN MEDAL (INAUGURAL AWARD) The Biemann Medal multiply-charged anions.
    [Show full text]
  • Keith R. Jennings
    CHEMICAL HERITAGE FOUNDATION KEITH R. JENNINGS Transcript of an Interview Conducted by Michael A. Grayson at Leamington Spa Warwickshire, United Kingdom on 24 and 25 April 2008 (With Subsequent Corrections and Additions) ACKNOWLEDGMENT This oral history is one in a series initiated by the Chemical Heritage Foundation on behalf of the American Society for Mass Spectrometry. The series documents the personal perspectives of individuals related to the advancement of mass spectrometric instrumentation, and records the human dimensions of the growth of mass spectrometry in academic, industrial, and governmental laboratories during the twentieth century. This project is made possible through the generous support of the American Society for Mass Spectrometry. This oral history is designated Free Access. One may view, quote from, cite, or reproduce the oral history with the permission of CHF. Please note: Users citing this interview for purposes of publication are obliged under the terms of the Chemical Heritage Foundation (CHF) Oral History Program to notify CHF of publication and credit CHF using the format below: Keith R. Jennings, interview by Michael A. Grayson at Leamington Spa, Warwickshire, United Kingdom, 24-25 April 2008 (Philadelphia: Chemical Heritage Foundation, Oral History Transcript # 0419). Chemical Heritage Foundation Oral History Program 315 Chestnut Street Philadelphia, Pennsylvania 19106 The Chemical Heritage Foundation (CHF) serves the community of the chemical and molecular sciences, and the wider public, by treasuring the past, educating the present, and inspiring the future. CHF maintains a world-class collection of materials that document the history and heritage of the chemical and molecular sciences, technologies, and industries; encourages research in CHF collections; and carries out a program of outreach and interpretation in order to advance an understanding of the role of the chemical and molecular sciences, technologies, and industries in shaping society.
    [Show full text]
  • The 1995 ASMS Award for Distinguished Contribution in Mass Spectrometry
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector 4.58 ASMS NEWS The American Society for Mass Spectrometry The 1995 ASMS Award for Distinguished Contribution in Mass Spectrometry Keith R. Jennings University of Warwick, Coventry, England For the discovery and application of Collision-Induced Dissociation The ASMS Award for a Distinguished Contribution The technique, collision-induced dissociation or CID in Mass Spectrometry recognizes a focused, singular (sometimes called collisionally-activated decomposition or achievement that significantly changes the practice of CAD) has had tremendous impact. CID forms the basis of mass spectrometry. The 1995 Award will be presented to most tandem mass spectrometric (MS/MS) experiments Professor Keith R. JeMingS of the University of Warwick, and has been the primary tool for ion structure Coventry, England, on May 24, at the ASMS Conference characterization. His research truly revolutionized mass in Atlanta. Prof. Jennings is acknowledged for his spectrometry and allowed for the application of mass pioneering research that led to the discovery of collision- spectrometty to mixture and molecular structure analyses induced dissociation (CID), which was published in IIL!, in numerous fields, including polymer science, natural 1,227, in 1968. products, drug metabolism, environmental analyses and Prof. Jennings’ research on metastable ions and their biochemistry. decompositions provided fundamental information on This is the sixth ASMS Award for Distinguished these phenomena and new methods by which double- Contribution. The awardee will receive a $3,000 cash focusing and later tandem mass spectrometers could be award and a recognition plaque. The presentation of this scanned for these studies.
    [Show full text]