Cellular Homeostasis Lecture Series Graduate Student Seminar Course: Pathology 575 - Frontiers of Pathology Thursday, in McKibben (MCH) Lecture Hall, Room 156 1333 San Pablo Street, Los Angeles CA 90033

April 4, 2019 12:00-1:00pm : connecting quality control & metabolic functions Vojo Deretic, Ph.D. Professor University of New Mexico

Vojo Deretic is a professor and chair of the Department of Molecular and at University of New Mexico. Professor Deretic obtained Ph. D. in Molecular Biology from University of Belgrade. After a short postdoctoral fellowship at University of Chicago, Illinois, Dr. Deretic joined University of Texas, San Antonio as an assistant professor and became a tenured professor. Dr. Deretic subsequently moved to University of New Mexico as a professor. Dr. Deretic is also the director of the NIH-funded Autophagy, Inflammation and (AIM) in Disease Center that would revolutionize autophagy research. Dr. Deretic is a world leader in studying how autophagy is utilized by immune cells to combat pathogens. In recent years, Dr. Deretic’s group revealed the role of secretory autophagy, the unconventional role of autophagy in secreting inflammatory molecules.

Secretory autophagy and inflammation 1. control mTOR in response to endomembrane damage. Mol Cell 2018;70:120-135. 2.Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins. J Cell Biol 2018;217:997-1013. 3.Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy. EMBO J 2017;36:42-60. 4.TRIMs and galectins globally cooperate and TRIM16 and -3 co-direct autophagy in endomembrane damage homeostasis. Dev Cell 2016;39:13-27. 5.Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β. EMBO J 2011;30(23):4701-11. 6.Autophagy is a defense mechanism inhibiting BCG and Mycobacterium survival in infected macrophages. Cell 2004;119:753-66.

Host/Moderator: Raymond Wu ( [email protected] )

Seminar is open to all faculty, staff, and students.