Supporting Information for Proteomics DOI 10.1002/pmic.200401246
Yufeng Shen, Jeongkwon Kim, Eric F. Strittmatter, Jon M. Jacobs, David G. CampII, Ruihua Fang, Nikola Toliñ, Ronald J. Moore and Richard D. Smith
Characterization of the human bloodplasma proteome
ã 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim www.proteomics-journal.de Supplementary Table 1. The 3712 human plasma proteins (identified with high confidence) and their interaction distributions.1,2 1. One set of comprehensive identification criteria (described in the text) was applied for protein identifications. 2. ORF: open reading frames; CS: peptide charge states; “A”, “G”, “P”, “O” in the column “Group”: the proteins were found in the albumin-interaction group (A), the immunoglobulin-interaction group (G), the plasma free-protein group (P), and the original whole plasma, respectively; Some proteins were found in more than two groups and listed in one cell.
ORF Description Peptide CS Xcorr DelCn Group IPI Reference FAB' FRAGMENT OF MONOCLONAL 3D:1bbjH ANTIBODY B72.3 (MURINE/HUMAN H.TFPAVLQSSGLY.S 2 2.742 0.380 G, O CHIMERA) H.TFPAVLQSSGLYSL.S 2 3.576 0.263 H.WGQGTTLTVSSASTK.G 2 2.676 0.134 K.DYFPEPVTV.S 1 2.127 0.138 K.DYFPEPVTVS.W 1 2.302 0.307 2 2.672 0.341 K.DYFPEPVTVSW.N 1 2.011 0.313 2 2.948 0.339 K.DYFPEPVTVSWN.S 1 3.119 0.380 2 4.342 0.428 K.DYFPEPVTVSWNSGAL.T 1 3.524 0.342 2 3.337 0.431 K.DYFPEPVTVSWNSGALT.S 1 2.094 0.153 K.DYFPEPVTVSWNSGALTS.G 1 2.096 0.181 K.DYFPEPVTVSWNSGALTSGVH.T 2 4.318 0.443 K.DYFPEPVTVSWNSGALTSGVHTFPA.V 2 4.167 0.423 K.DYFPEPVTVSWNSGALTSGVHTFPAVL 2 3.413 0.490 .Q K.DYFPEPVTVSWNSGALTSGVHTFPAVL 2 4.192 0.422 Q.S K.DYFPEPVTVSWNSGALTSGVHTFPAVL 2 4.153 0.411 QS.S K.DYFPEPVTVSWNSGALTSGVHTFPAVL 2 4.063 0.481 QSS.G K.DYFPEPVTVSWNSGALTSGVHTFPAVL 2 2.856 0.229 QSSGL.Y K.DYFPEPVTVSWNSGALTSGVHTFPAVL 2 3.609 0.374 QSSGLY.S 3 6.199 0.467 K.DYFPEPVTVSWNSGALTSGVHTFPAVL 2 2.689 0.374 QSSGLYSL.S 3 5.406 0.460 K.DYFPEPVTVSWNSGALTSGVHTFPAVL 3 5.441 0.372 QSSGLYSLS.S K.DYFPEPVTVSWNSGALTSGVHTFPAVL 3 3.706 0.360 QSSGLYSLSS.V K.GPSVFPLAPCSR.S 1 2.297 0.217 L.TSGVHTFPAVL.Q 1 2.223 0.323 L.TSGVHTFPAVLQ.S 1 2.584 0.366 L.TSGVHTFPAVLQS.S 1 2.906 0.321 2 2.703 0.137 L.TSGVHTFPAVLQSS.G 1 2.617 0.288 2 2.745 0.191 L.TSGVHTFPAVLQSSGL.Y 2 3.461 0.282 L.TSGVHTFPAVLQSSGLY.S 1 3.593 0.432 2 3.858 0.314 L.TSGVHTFPAVLQSSGLYS.L 2 2.498 0.195 L.TSGVHTFPAVLQSSGLYSL.S 1 4.383 0.499 2 4.441 0.395 L.TSGVHTFPAVLQSSGLYSLS.S 2 2.446 0.201 N.SGALTSGVHTFPA.V 1 2.069 0.180 2 3.370 0.211 N.SGALTSGVHTFPAVL.Q 1 2.730 0.247 2 3.103 0.352 Supplementary Table 1 1 N.SGALTSGVHTFPAVLQ.S 2 3.008 0.268 N.SGALTSGVHTFPAVLQS.S 2 3.337 0.253 N.SGALTSGVHTFPAVLQSSGL.Y 1 3.082 0.372 2 2.612 0.332 N.SGALTSGVHTFPAVLQSSGLY.S 2 4.310 0.342 N.SGALTSGVHTFPAVLQSSGLYSL.S 2 5.448 0.477 N.SGALTSGVHTFPAVLQSSGLYSLS.S 2 4.271 0.401 S.WNSGALTSGVHTFPAVLQSSGLY.S 2 4.092 0.435 S.WNSGALTSGVHTFPAVLQSSGLYSL.S 2 3.093 0.305 V.SWNSGALTSGVHTFPAVLQS.S 2 2.886 0.329 V.TVSWNSGALTSGVHTFPAVLQSS.G 2 2.455 0.234 V.TVSWNSGALTSGVHTFPAVLQSSGLY. 2 3.416 0.335 S W.NSGALTSGVHTFPAVLQSSGLY.S 2 3.813 0.314 W.NSGALTSGVHTFPAVLQSSGLYSL.S 2 3.158 0.331 3D:1clyH IGG FAB (HUMAN IGG1, KAPPA); F.PLAPSSK.S 1 2.160 0.180 A, G, O, P G.PSVFPLAPSSK.S 2 3.451 0.296 K.DYFPQPVTVSWNSGALTSGVHTFPAV 2 2.979 0.383 L.Q K.GPSVFPLAPSS.K 1 1.862 0.204 K.GPSVFPLAPSSK.S 1 3.335 0.301 2 3.211 0.290 K.NSLYLQM.S 1 1.820 0.116 K.STSGGTAALGCLVK.D 1 2.374 0.145 2 3.586 0.369 N.LVESGGGLVQPGGSLK.V 2 3.757 0.140 P.SVFPLAPSSK.S 1 2.325 0.253 S.SVVTVPSSSLGTQTY.I 2 2.777 0.356 S.VFPLAPSSK.S 1 2.582 0.255 S.VVTVPSSSLGTQTY.I 2 3.560 0.317 V.FPLAPSSK.S 1 2.285 0.130 Y.SLSSVVTVPSSSLGTQTY.I 1 2.250 0.307 3D:1clyL IGG FAB (HUMAN IGG1, KAPPA); A.PSVFIFPPSDEQLK.S 1 3.170 0.350 A, G, O, P 2 3.797 0.286 F.SGSGSGTDFTLK.I 1 1.825 0.136 2 2.474 0.295 K.RTVAAPSVFIFPPSDEQLK.S 2 5.340 0.447 3 4.287 0.268 R.FSGSGSGTDFTLK.I 1 2.928 0.312 2 4.012 0.391 R.TVAAPSVF.I 1 2.128 0.141 R.TVAAPSVFIFPPSD.E 2 3.341 0.400 R.TVAAPSVFIFPPSDEQLK.S 1 3.704 0.466 2 4.284 0.333 3 5.007 0.201 S.GSGSGTDFTLK.I 1 1.928 0.222 FV FRAGMENT OF HUMANIZED 3D:1fvcB K.NTAYLQMN.S 1 2.176 0.208 G ANTIBODY 4D5, VERSION 8 FAB FRAGMENT OF HUMANIZED 3D:1fvdB G.QGTLVTVSSASTK.G 1 2.135 0.268 G, O ANTIBODY 4D5, VERSION 4 L.VTVSSASTK.G 1 2.067 0.332 Q.GTLVTVSSASTK.G 1 2.288 0.296 2 3.641 0.234 T.LVTVSSASTK.G 1 1.846 0.213 V.WGQGTLVTVSSASTK.G 1 2.968 0.390 2 4.190 0.365 W.GQGTLVTVSSASTK.G 1 1.897 0.124 2 3.568 0.412 CHIMERA OF IG KAPPA CHAIN: 3D:1i7zA -.DLVLTQSPASL.A 2 2.996 0.309 G HUMAN CONSTANT REGION CHIMERA OF IG KAPPA CHAIN: 3D:1i7zB Q.GTTVTVSSASTK.G 1 2.615 0.438 A, G, O HUMAN CONSTANT REGION 2 3.230 0.469 Q.GTTVTVSSASTKGPSVFPLAPSSK.S 2 3.182 0.282 HUMAN MONOCLONAL BO2C11 N.SGALTSGVHTFPAVLQSSGLYSLSSVV IPI:IPI00031838.1 3D:1iqdB 3 3.948 0.253 G, O FAB LIGHT CHAIN; TVPSSSLGTA.T (98%) Supplementary Table 1 2 Q.GTMVTVSSASTK.G 1 2.342 0.311 2 3.450 0.367 Q.LVQSGAEVK.K 1 1.833 0.105 Q.VQLVQSGAEVK.K 1 2.233 0.185 2 3.283 0.204 T.MVTVSSASTK.G 1 2.184 0.316 A5B7 humanised mouse monoclonal GP:A20585_1 T.YIHWYQQK.P 1 2.478 0.146 G antibody A5B7 light chain sequence. V.TYIHWYQQK.P 2 2.474 0.367 A5B7 humanised mouse monoclonal GP:A20587_1 antibody A5B7 heavy chain C.EVKLVESGGGL.V 1 2.904 0.233 A, G, O, P sequence. C.EVKLVESGGGLVQ.P 2 3.783 0.104 C.EVKLVESGGGLVQPGGSLR.L 1 3.875 0.179 2 5.323 1.000 3 4.164 0.125 Plasmid DNA with human cDNA GP:A21385_1 A.LHNHYTQK.S 1 2.522 0.166 A, G, O, P insert. A.PELLGGPSVFLFPPKPK.D 2 4.453 0.316 3 4.692 0.319 C.DKTHTCPPCPAPELLGGPSVFLFPPKP 3 4.917 0.208 K.D C.EVQLVESGGGLVQPGR.S 1 3.165 0.285 2 4.368 0.357 3 3.900 0.294 C.PAPELLGGPSVFLFPPKPK.D 2 4.501 0.355 3 4.394 0.274 C.PPCPAPELLGGPSVFLFPPKPK.D 2 2.954 0.192 C.SVMHEALHNHYTQK.S 1 2.690 0.273 2 5.062 0.442 3 4.070 0.286 D.GVEVHNAK.T 1 1.962 0.267 D.KTHTCPPCPAPELLGGPSVFLFPPKPK. 3 5.235 0.287 D D.SDGSFFLYSK.L 1 2.166 0.265 2 3.065 0.363 D.VSHEDPEVK.F 1 1.905 0.227 E.ALHNHYTQK.S 2 2.414 0.212 E.LLGGPSVFLFPPK.P 2 3.247 0.299 E.LLGGPSVFLFPPKPK.D 2 4.332 0.338 E.PQVYTLPPSR.D 1 2.319 0.111 2 2.970 0.225 E.WESNGQPENNYK.T 1 2.177 0.294 F.NWYVDGVEVHNAK.T 1 3.128 0.225 2 4.526 0.418 G.GPSVFLFPPKPK.D 2 3.456 0.301 H.EALHNHYTQK.S 1 2.705 0.353 2 3.255 0.305 H.TCPPCPAPELLGGPSVFLFPPKPK.D 2 2.863 0.136 I.AVEWESNGQPENNYK.T 2 2.674 0.266 K.AKGQPREPQVYTLPPSR.D 3 4.022 0.306 K.ALPAPIEK.T 1 2.190 0.134 K.ALPAPIEKTISK.A 1 1.846 0.093 2 2.310 0.316 K.DTLMISR.T 1 1.966 0.150 2 2.608 0.096 K.FNWYVDGVEVH.N 1 2.457 0.103 2 4.085 0.407 K.FNWYVDGVEVHN.A 1 2.515 0.191 2 4.640 0.337 K.FNWYVDGVEVHNA.K 2 3.884 0.322 K.FNWYVDGVEVHNAK.T 1 4.019 0.378 2 5.260 0.479 3 3.784 0.302 K.GFYPSDIAVEWES.N 1 2.838 0.331 Supplementary Table 1 3 2 3.502 0.200 K.GFYPSDIAVEWESN.G 1 2.661 0.298 K.GFYPSDIAVEWESNGQPENNYK.T 2 4.746 0.368 K.GFYPSDIAVEWESNGQPENNYKTTPP 3 3.702 0.337 VLDSDGSFFLYSK.L K.GQPREPQVYTLPPSR.D 2 3.261 0.139 K.LTVDKSR.W 1 1.843 0.081 K.NQVSLTCLVK.G 2 2.603 0.161 K.NSLYLQMN.S 1 2.350 0.092 K.NSLYLQMNSLR.A 2 4.033 1.000 K.PKDTLMISR.T 1 1.928 0.177 K.SCDKTHTCPPCPAPELLGGPSVFLFPP 3 4.847 0.357 KPK.D K.THTCPPCPAPELLGGPSVF.L 1 3.467 0.329 2 3.653 0.218 K.THTCPPCPAPELLGGPSVFLFPPK.P 2 3.093 0.221 3 4.929 0.307 K.THTCPPCPAPELLGGPSVFLFPPKPK.D 2 4.069 0.195 3 5.987 0.368 K.TTPPVLDSDGSF.F 1 2.130 0.361 2 3.169 0.318 K.TTPPVLDSDGSFF.L 1 1.980 0.382 2 3.940 0.301 K.TTPPVLDSDGSFFL.Y 2 4.008 0.267 K.TTPPVLDSDGSFFLY.S 1 3.012 0.337 K.TTPPVLDSDGSFFLYSK.L 1 3.345 0.349 2 2.963 0.371 3 5.019 0.327 K.VEPKSCDKTHTCPPCPAPELLGGPSVF 3 3.503 0.102 LFPPKPK.D K.VSNKALPAPIEK.T 2 3.452 0.252 K.VSNKALPAPIEKTISK.A 3 4.551 0.313 L.GGPSVFLFPPKPK.D 2 3.488 0.358 L.HQDWLNGK.E 1 2.010 0.106 L.LGGPSVFLFPPKPK.D 2 3.267 0.305 L.TVLHQDWLNGK.E 1 2.712 0.286 2 3.780 0.273 L.TVLHQDWLNGKEYK.C 2 2.426 0.247 M.HEALHNHYTQK.S 2 4.261 0.413 N.HYTQKSLSLSPG.K 2 3.083 0.290 N.KALPAPIEK.T 1 2.073 0.311 2 2.675 0.168 N.VFSCSVMHEALHNHYTQK.S 2 3.295 0.093 3 3.770 0.152 N.WYVDGVEVH.N 2 3.356 0.320 N.WYVDGVEVHN.A 2 3.363 0.379 N.WYVDGVEVHNAK.T 1 3.166 0.405 2 4.654 0.432 P.APELLGGPSVF.L 1 2.772 0.248 P.APELLGGPSVFLFPPKPK.D 1 2.949 0.216 2 4.786 0.411 3 4.524 0.444 P.CPAPELLGGPSVFLFPPKPK.D 2 3.223 0.299 P.PCPAPELLGGPSVFLFPPKPK.D 2 2.599 0.242 P.PVLDSDGSFFLYSK.L 1 3.553 0.420 2 3.460 0.439 P.QVYTLPPSR.D 1 2.045 0.118 Q.LVESGGGLVQPGR.S 1 2.531 0.207 2 3.556 0.286 Q.PENNYK.T 1 1.980 0.085 R.EPQVYTLPPSR.D 1 2.877 0.116 2 2.368 0.183 R.TPEVTCVVVDVSHEDPEVK.F 2 5.746 0.398 3 4.081 0.262
Supplementary Table 1 4 R.VVSVLTVLHQD.W 1 2.235 0.248 2 3.921 0.180 R.VVSVLTVLHQDWL.N 1 2.699 0.360 2 3.789 0.324 R.VVSVLTVLHQDWLN.G 1 2.742 0.241 2 3.292 0.296 R.VVSVLTVLHQDWLNGK.E 1 3.596 0.336 2 5.192 0.402 3 3.831 0.330 R.VVSVLTVLHQDWLNGKEYK.C 2 4.453 0.304 3 4.159 0.483 R.WQQGNVFSCSVMHEALHNHYTQK.S 3 3.614 0.263 S.DIAVEWESNGQPENNYK.T 2 2.259 0.144 S.VLTVLHQDWLNGK.E 2 2.827 0.167 S.VLTVLHQDWLNGKEYK.C 2 2.526 0.203 S.VMHEALHNHYTQK.S 1 3.426 0.405 2 4.952 0.470 T.CPPCPAPELLGGPSVFLFPPKPK.D 3 3.839 0.265 T.CVVVDVSHEDPEVK.F 2 3.535 0.375 T.HTCPPCPAPELLGGPSVFLFPPKPK.D 2 2.601 0.195 T.PPVLDSDGSFF.L 1 2.254 0.109 T.PPVLDSDGSFFLYSK.L 1 4.192 0.306 2 5.980 0.409 T.TPPVLDSDGSFFLYSK.L 2 2.844 0.303 V.DGVEVHNAK.T 1 2.490 0.253 V.LDSDGSFFLYSK.L 1 2.409 0.259 V.LHQDWLNGK.E 1 2.045 0.116 V.LTVLHQDWLNGK.E 1 2.097 0.247 2 4.166 0.122 V.LTVLHQDWLNGKEYK.C 2 3.027 0.208 V.SVLTVLHQDWLNGK.E 1 2.354 0.241 2 4.555 0.310 V.SVLTVLHQDWLNGKEYK.C 2 3.624 0.127 V.VSVLTVLHQDWLNGK.E 2 3.390 0.388 V.VSVLTVLHQDWLNGKEYK.C 2 3.335 0.222 W.YVDGVEVHNAK.T 1 3.179 0.394 2 3.823 0.456 Y.PSDIAVEWESNGQPENNYK.T 2 4.191 0.530 Y.VDGVEVH.N 1 2.026 0.153 Y.VDGVEVHNAK.T 1 2.530 0.124 2 3.399 0.329 Plasmid DNA with human cDNA S.GGGGSGGGGSGGGGSDIQMTQSPST IPI:IPI00003457.1 GP:A21387_1 3 3.941 0.270 G, P insert. LSASVGDR.V (96%) IPI:IPI00022434.1 GP:A30884_1 Synthetic human serum albumin gene. K.VFDEFKPLMEEPQNLIK.Q 2 3.538 0.430 A (99%) 3 4.599 0.350 Homo sapiens mRNA for DAP-2, GP:AB000275_1 E.FPEHQPYPRSDVETATDSDTESRGL.R 3 3.851 0.083 G partial cds. Homo sapiens mRNA, complete cds, GP:AB000459_1 clone:RES4-22A,; unnamed protein A.PLPPATDGSISAPPSV.C 1 2.568 0.140 G product. K.AKVVDLMSITEQKRE.E 1 1.905 0.193 Homo sapiens mRNA for UDP- GlcNAc:a-1,3-D-mannoside b-1,4-N- IPI:IPI00016743.1 GP:AB000616_1 I.LEFSQL.G 1 2.252 0.087 G, O, P acetylglucosaminyltransferase IV, (97%) complete cds. S.KDALNK.F 1 1.914 0.082 Homo sapiens mRNA for single-chain IPI:IPI00017248.1 GP:AB001733_1 G.NHVVFGGGTK.L 1 2.115 0.180 G, O, P antibody, complete cds. (98%) H.VVFGGGTK.L 1 1.845 0.144 K.NNRPSGIPDR.F 2 3.152 0.217 K.PGQAPVLVIYGK.N 1 3.181 0.260 2 3.996 0.158 M.EVQLVESGGGLIQPGGSLR.L 2 4.851 0.328 3 3.969 0.152 N.HVVFGGGTK.L 1 2.110 0.379 Supplementary Table 1 5 Q.LVESGGGLIQPGGSLR.L 2 3.717 0.164 R.DSSGNHVVFGGGTK.L 2 2.503 0.189 R.SYYASWYQQK.P 2 3.498 0.361 S.SELTQDPAVSVA.L 2 2.437 0.255 S.SELTQDPAVSVALGQTVR.I 1 2.051 0.226 2 5.151 0.402 3 4.343 0.342 S.TYYADSVK.G 1 2.110 0.226 T.YYADSVK.G 1 2.587 0.226 Y.YASWYQQK.P 2 2.833 0.136 Human mRNA for KIAA0294 gene, IPI:IPI00162731.2 GP:AB002292_1 Y.EKKMRDLMASTVGVVEIQQ.L 2 2.947 0.162 O, P complete cds. (93%) Human mRNA for KIAA0295 gene, GP:AB002293_1 K.ESTSSDCKLPTSEE.S 1 2.341 0.108 G partial cds. Human mRNA for KIAA0306 gene, GP:AB002304_1 R.PRAFSHSGVHSLDGGEVDS.Q 2 2.756 0.182 G partial cds. Human mRNA for KIAA0308 gene, GP:AB002306_1 D.QSTQMSKEGGLKLTFQK.Q 1 1.948 0.114 G, P partial cds. Y.KKHIKHHCNKVLLR.V 2 2.470 0.183 Human mRNA for KIAA0314 gene, GP:AB002312_1 G.ECQTTIQGQARNKRKQETK.S 3 3.667 0.187 P partial cds. Human mRNA for KIAA0315 gene, IPI:IPI00150545.1 GP:AB002313_1 K.LFKAIKHQ.V 1 2.069 0.200 A, P partial cds. (99%) R.GSVKEKERTKAITEIYLTR.L 2 2.497 0.126 Human mRNA for KIAA0321 gene, IPI:IPI00004465.1 GP:AB002319_1 A.LLAQENLSLSVPQ.V 2 2.790 0.087 A, G partial cds. (92%) V.KAGQSQDLALCDSYISK.V 1 2.017 0.106 Human mRNA for KIAA0322 gene, GP:AB002320_1 I.ATERSEEDSGSQSCEQAPA.G 2 2.684 0.187 A, G, P partial cds. L.ESPVAGPSNRREGECPIL.H 1 2.191 0.146 T.NGAGPWQDELAAPSGHVERSPEGLES 2 2.681 0.320 PV.A Human mRNA for KIAA0323 gene, IPI:IPI00027527.2 GP:AB002321_1 G.DTYAVEKEGGTQGGPREMDL.G 2 2.455 0.244 G, O, P partial cds. (92%) G.IRKTRETERLRRQLLEVF.W 2 2.456 0.153 G.WTWGDGEHGLGAAAMPTWGAR.P 2 2.358 0.140 R.PQSVGGGA.R 1 1.884 0.122 Homo sapiens mRNA for KIAA0324 protein, partial cds; Start codon is not identified. hg00514 cDNA clone for GP:AB002322_1 A.TASPPRQKDKFSPFPVQDRP.E 2 2.919 0.102 A, O KIAA0324 has a 724-bp insertion between 5116-5117 of the sequence of KIAA0324. R.RSSSSSSSSSSS.S 1 2.066 0.223 Human mRNA for KIAA0326 gene, IPI:IPI00018411.1 GP:AB002324_1 F.YRSSDLIQHQATHTGEKPYK.C 2 2.474 0.157 G, O partial cds. (92%) V.PANEPSLRELVQ.G 1 2.350 0.104 Homo sapiens mRNA for KIAA0328 protein, partial cds; Start codon is not identified. hg00685 cDNA clone for IPI:IPI00178743.1 GP:AB002326_1 A.SVQVLITGDENLS.D 2 3.014 0.114 O KIAA0328 has a 139-bp insertion (94%) between 4902-4903 of the sequence of KIAA0328. Q.NENADASVQVLI.T 2 2.655 0.137 Human mRNA for KIAA0332 gene, GP:AB002330_1 L.LVIETKKPPLKKGE.K 2 2.848 0.087 A partial cds. Human mRNA for KIAA0333 gene, GP:AB002331_1 A.VSRSISAFTLLHCISCK.V 2 2.321 0.135 A, G partial cds. E.ISLAKLVRLK.P 2 2.630 0.088 S.KKFPGSAALVGA.V 2 2.805 0.112 Homo sapiens mRNA for KIAA0339 protein, partial cds; Start codon is not identified. hg01304 cDNA clone for GP:AB002337_1 G.QIPLK.E 1 1.902 1.000 O KIAA0339 has a 1-bp deletion at the position 3561 of the sequence of KIAA0339. S.SVSGEEARLPPREEAEL.A 2 2.799 0.086 Human mRNA for KIAA0353 gene, IPI:IPI00216094.1 GP:AB002351_1 A.CPEAWGSPEPGPAESSADMDG.S 2 2.466 0.247 A, P partial cds. (94%) R.SPAPGSPDEEGGAEAPAAGIRFR.R 2 2.292 0.147 Human mRNA for KIAA0354 gene, IPI:IPI00006671.1 GP:AB002352_1 F.LNKSRGNNFTANQNNDDNIPNT.T 2 3.240 0.138 O complete cds. (91%) Supplementary Table 1 6 Homo sapiens mRNA for KIAA0356 protein, partial cds; Start codon is not identified. hh00006 cDNA clone for IPI:IPI00179028.1 GP:AB002354_1 F.YRPSREQPLESASDHPIASYR.G 2 2.950 0.081 A KIAA0356 has a 123-bp insertion (97%) between 419-420 of the sequence of KIAA0356. Human mRNA for KIAA0358 gene, IPI:IPI00107843.1 GP:AB002356_1 E.VCDDCVVLR.S 1 2.015 0.173 A, G, O, P complete cds. (92%) L.KEVVHSVLDGQ.G 1 2.174 0.095 Human mRNA for KIAA0360 gene, GP:AB002358_1 P.GSEGSAISGVAESSTATR.M 2 3.108 0.143 P partial cds. Human mRNA for KIAA0370 gene, IPI:IPI00165943.1 GP:AB002368_1 K.VTLYGSQIKLYNIE.T 1 2.047 0.086 G, O partial cds. (92%) S.RQICYQSLQESVQVSLALF.P 2 2.845 0.162 Homo sapiens mRNA for KIAA0375 protein, partial cds; Start codon is not identified. hh00360 cDNA clone for GP:AB002373_1 F.EFPGSLSAASHLNCRLNGQAVK.P 2 2.860 0.122 P KIAA0375 has a 108-bp insertion between 4366-4367 of the sequence of KIAA0375. Human mRNA for KIAA0381 gene, GP:AB002379_1 F.LYEMSRIDHYQQRLQALFFKKK.F 3 3.503 0.148 O partial cds. Human mRNA for KIAA0386 gene, IPI:IPI00016800.3 GP:AB002384_1 F.LPLIVGFISIKVTEL.K 1 2.096 0.184 A, G complete cds. (92%) L.NTSDFDEEEDGDE.V 2 2.462 0.134 Homo sapiens mRNA for KIAA0393 protein, partial cds; Start codon is not identified. hg01266 cDNA clone for IPI:IPI00004587.1 GP:AB002391_1 KIAA0393 has a 1-bp deletion at the K.QSPVPALPIVVQLMEMGFPRR.N 2 2.227 0.181 G, O (93%) position 2336, and a 322-bp insertion between 3042-3043 of the sequence of KIAA0393. L.EGIDTILK.L 2 2.287 0.150 Homo sapiens mRNA for IgG kappa GP:AB004304_1 -.DIEMTQSPSSLSA.S 1 3.475 0.211 G, O, P chain, partial cds; C13-3 IgG VK-CL1. 2 3.924 0.177 -.DIEMTQSPSSLSAS.V 2 3.910 0.329 -.DIEMTQSPSSLSASVGDR.V 1 3.546 0.159 2 6.489 1.000 L.LIYAASSR.A 2 2.420 0.149 R.ASQSISSYLNWYQQKPGK.A 2 4.248 0.281 S.SYLNWYQQK.P 2 2.765 0.139 Gallus gallus mRNA for Wnt-5a, IPI:IPI00181909.1 GP:AB006014_1 complete cds; secretory protein; S.TAVLIQGGALGTL.G 1 2.071 0.134 P (93%) similar to mouse and human Wnt-5a. Homo sapiens mRNA for interleukin 1 IPI:IPI00031789.1 GP:AB006537_1 receptor accessory protein, complete K.FNYSTAHSAGL.T 1 2.015 0.104 O (95%) cds. Homo sapiens mRNA for KIAA0287 GP:AB006625_1 gene, partial cds; The human homolog P.GEGSGEFKKDGEFSVPSSNVR.E 3 4.170 0.095 A, O, P of a mouse imprinted gene, Peg3.. Homo sapiens mRNA for KIAA0291 L.DQAQQVEKLMEAMRSCPDKAQTIGNS IPI:IPI00031799.1 GP:AB006629_1 3 3.919 0.222 A gene, partial cds. GSANGIHQQ.D (91%) Gallus gallus mRNA for BMP type II receptor, complete cds; similar to GP:AB006785_1 D.SRLNINSSPDEHEPLL.R 2 2.821 0.172 A, O human BRK-3, a type II receptor for BMP-4. Homo sapiens mRNA for HRV Fab IPI:IPI00024134.1 GP:AB006842_1 A.ASSLQSGVPSR.F 1 2.222 0.118 G, P N6-VL, partial cds. (91%) 2 3.349 0.211 K.LLIYAASSLQSGVPSR.F 2 2.342 0.126 L.LIYAASSLQSGVPSR.F 2 2.587 0.155 S.TPITFGQGTR.L 2 2.807 0.241 Y.AASSLQSGVPSR.F 2 3.277 0.309 Homo sapiens mRNA for HRV Fab IPI:IPI00003486.1 GP:AB006844_1 A.ELTLTQSPGTLSL.S 2 3.436 0.080 G, O, P N27-VL, partial cds. (93%) A.ELTLTQSPGTLSLSPGER.A 1 2.699 0.259 2 5.461 0.258 A.SQSVSSSYLAWYQQKPGQAPR.L 2 3.627 0.087 L.LIYGASSR.A 2 2.251 0.235 R.ASQSVSSSYLAWYQQK.P 1 3.074 0.357 2 4.764 0.371
Supplementary Table 1 7 R.ASQSVSSSYLAWYQQKPGQAPR.L 2 4.884 0.271 R.LLIYGASSR.A 1 1.848 0.110 2 2.834 0.207 Homo sapiens mRNA for HRV Fab IPI:IPI00160257.2 GP:AB006846_1 A.ELQMTQSPSSLSASVGDR.V 2 2.987 0.179 A, G 025-VL, partial cds. (91%) Homo sapiens mRNA for HRV Fab IPI:IPI00030206.1 GP:AB006848_1 A.ELVMTQSPATL.S 2 3.414 0.256 G 026-VL, partial cds. (92%) A.ELVMTQSPATLSLSPGEGA.T 2 2.952 0.164 Homo sapiens mRNA for PRP8 IPI:IPI00007928.1 GP:AB007510_1 K.YELQLANPKEFY.H 1 2.454 0.127 O, P protein, complete cds. (97%) V.GFQVQLDLTGIFMHGKIPTL.K 2 2.799 0.242 Homo sapiens KIAA0407 mRNA, IPI:IPI00006644.4 GP:AB007867_1 A.GVPCAVDAQEYEVSSSLVCITGA.S 2 2.577 0.153 A, P complete cds. (96%) F.PVAAQVGLGVGTSLL.A 2 2.569 0.154 Homo sapiens KIAA0421 mRNA, IPI:IPI00184081.1 GP:AB007881_1 M.EREITR.S 1 1.894 0.117 G, P partial cds. (97%) T.QSQSIYNNLVSFASPLV.T 1 2.376 0.080 Homo sapiens KIAA0424 mRNA, IPI:IPI00181915.1 GP:AB007884_1 Q.EDEKIGFEISENQK.R 1 2.860 0.089 A partial cds. (98%) Homo sapiens mRNA for KIAA0445 GP:AB007914_1 V.QRQLAQLE.A 1 2.177 0.084 A protein, complete cds. Homo sapiens mRNA for KIAA0446 protein, partial cds; Start codon is not identified. hg00104 cDNA clone for GP:AB007915_1 R.KFVADYSQSNTVK.S 2 2.844 0.091 A KIAA0446 has a 5-bp deletion at the region from 4268 to 4272 of the sequence of KIAA0446. Homo sapiens mRNA for KIAA0453 protein, partial cds; Start codon is not identified. hg00489 cDNA clone for T.EQELQKLKNPDTEQELEVLVRLEGGIG IPI:IPI00186628.1 GP:AB007922_1 3 3.624 0.081 O KIAA0453 has a 1-bp deletion at the LSLINK.V (97%) position 3149 of the sequence of KIAA0453. Homo sapiens mRNA for KIAA0456 IPI:IPI00006709.2 GP:AB007925_1 R.HGLQHEGIFRVSGSQVEVND.I 2 2.660 0.123 A protein, partial cds. (99%) Homo sapiens mRNA for KIAA0458 GP:AB007927_1 G.RNSPSAASTSSNDSKAETV.K 1 2.209 0.171 G protein, complete cds. Homo sapiens mRNA for KIAA0463 IPI:IPI00018707.2 GP:AB007932_1 A.KLPAISDQDMNAYLAEQ.S 2 3.181 0.129 P protein, partial cds. (96%) Homo sapiens mRNA for CDEP, IPI:IPI00024773.1 GP:AB008430_1 K.QVLDYVKE.G 1 2.543 0.097 P complete cds; Band 4.1 superfamily. (93%) Homo sapiens mRNA for 26S GP:AB009619_1 proteasome subunit p28, complete L.HIAASAGRDEIVKALLGK.G 2 2.666 0.101 A cds. Homo sapiens mRNA for KIAA0528 protein, partial cds; Start codon is not identified. hg02576 cDNA clone for IPI:IPI00030661.1 GP:AB011100_1 L.NKNFNDLCENLLKS.L 2 2.883 0.084 A, G KIAA0528 has a nucleotide (95%) substitution at the position 401 ( C - T ) of the sequence of KIAA0528. T.DVPPPSGFYSCNTEI.M 1 2.406 0.116 Homo sapiens mRNA for KIAA0530 D.SQMMALNSCTTSVNSDLQISEDNVIQN IPI:IPI00164352.2 GP:AB011102_1 3 3.717 0.098 A, O, P protein, partial cds. FEK.T (96%) S.NIPQSEVSHKEDQIQEILEGLQKLKLEN 3 3.852 0.145 DLSTPASQCVL.I V.APPLIAPN.A 1 2.024 0.195 Homo sapiens mRNA for KIAA0535 C.PHKVRVPLEILAMHENVLKCPTPGCTG IPI:IPI00005704.1 GP:AB011107_1 2 2.371 0.192 G, O protein, complete cds. R.G (95%) Q.PSFPDVEEEDSESLAVMTEEGSDLEKA 3 4.235 0.120 KGNLSLLEQA.I Homo sapiens mRNA for KIAA0542 protein, partial cds; Start codon is not identified. hg04325 cDNA clone for GP:AB011114_1 KIAA0542 has a 933-bp insertion F.KDGAVKKPYSAKTLSNK.K 1 2.420 0.170 G between 3296-3297, and a 187-bp insertion between 3368-3369 of the sequence of KIAA0542. Homo sapiens mRNA for KIAA0545 GP:AB011117_1 H.PHPPVGPGATPAAGSGFPEK.K 2 2.840 0.116 A protein, partial cds. Homo sapiens mRNA for KIAA0556 IPI:IPI00030790.2 GP:AB011128_1 A.DHSILVDQKNE.K 2 2.659 0.094 O, P protein, partial cds. (93%) Q.RKQKDCSSDEYDSIEEDIL.S 2 2.552 0.140 Homo sapiens mRNA for KIAA0558 IPI:IPI00026812.2 GP:AB011130_1 K.VAGDIESLLDRKVQALK.R 2 3.106 0.138 O protein, partial cds. (93%) GP:AB011132_1 Homo sapiens mRNA for KIAA0560 L.IGRPNKVTTVDRFQGQQNDYIL.L 2 3.476 0.135 G IPI:IPI00028930.1 Supplementary Table 1 8 protein, partial cds; Start codon is not (95%) identified. hh01648 cDNA clone for KIAA0560 has a 41-bp deletion at the region from 388 to 428 of the sequence of KIAA0560. Homo sapiens mRNA for KIAA0561 GP:AB011133_1 R.PARLLECLEFDPEEFYHL.L 2 2.726 0.141 G protein, partial cds. Homo sapiens mRNA for KIAA0571 P.SNTLCREFGDLLVDNMDVPATPLSAYQ IPI:IPI00180242.1 GP:AB011143_1 3 3.654 0.156 G protein, complete cds. IPR.T (97%) Homo sapiens mRNA for KIAA0607 IPI:IPI00010345.1 GP:AB011179_1 L.AANVATLGLLMARLLSTSPA.L 1 2.079 0.183 A protein, partial cds. (93%) Y.QGVLVELAR.A 1 2.505 0.081 Homo sapiens mRNA for Trad, IPI:IPI00180957.1 GP:AB011422_1 C.DDLDPNTSMGILNPN.F 2 3.257 0.114 A, P complete cds. (98%) E.RSTAVMRSQPAR.L 2 2.528 0.084 Homo sapiens mRNA for CDC23, IPI:IPI00005822.1 GP:AB011472_1 L.HWGAWLELCNLITDKEMLK.F 3 3.512 0.164 O complete cds. (97%) Rattus norvegicus mRNA for MEGF3, IPI:IPI00015346.1 GP:AB011529_1 partial cds; rat homologue of human L.TREGSLGPLPGPSTQPHKGILKKKC.L 3 3.850 0.154 A, P (91%) KIAA0279 protein. T.PVVSISVHDDEELLPR.A 2 2.539 0.106 Homo sapiens gene for new zinc GP:AB012770_1 S.KINKVSCESGQPVK.S 2 2.570 0.088 P finger protein, complete cds. S.QRSLQMFK.V 1 1.828 0.082 Homo sapiens ING1L mRNA for GP:AB012853_1 L.KEIDDVYEK.Y 1 1.956 0.085 P ING1Lp, complete cds. 2 2.889 0.121 Homo sapiens mRNA for anti-HBsAg GP:AB012909_1 K.NTLYLEMN.S 1 2.664 0.080 G, P immunoglobulin, partial cds. K.NTLYLEMNSLTA.E 2 2.648 0.080 L.ESGGGVVQPGR.S 1 1.932 0.203 Homo sapiens IgH VDJ gene, partial GP:AB013458_1 cds; unable to identify D_segment or N.NTVYLQMNSLR.A 1 2.448 0.203 G, O, P D_gene. 2 3.660 0.175 Homo sapiens mRNA for KIAA0618 GP:AB014518_1 A.PSFGSSFTFGNSAAPAAAPTPAP.P 2 2.839 0.226 G, P protein, complete cds. F.QFGKPPALPTTTTVTTFSQSLHT.A 2 2.612 0.256 P.ALPTTTTVTTFSQSLHTAVPTATSSSA. 2 2.436 0.128 A Homo sapiens mRNA for KIAA0619 GP:AB014519_1 A.EEQYSDLEK.E 2 2.221 0.220 A, G protein, complete cds. K.LYTLEEHLSNEMQAKE.E 2 2.589 0.100 Homo sapiens mRNA for KIAA0621 GP:AB014521_1 K.EQIGAAKEAKKKYDKETEK.Y 2 2.838 0.098 P protein, partial cds. L.IPENYVEF.L 1 2.278 0.118 Homo sapiens mRNA for KIAA0626 GP:AB014526_1 I.MEVVGLEEQGQNF.V 2 2.703 0.174 P protein, complete cds. Homo sapiens mRNA for KIAA0654 GP:AB014554_1 E.MERMQMEIDQLR.G 1 2.646 0.115 G, O, P protein, partial cds. G.VKEEPSKDWER.S 2 2.298 0.108 Homo sapiens mRNA for KIAA0699 protein, partial cds; HG00621 cDNA E.AGRADGGTGDSSPSPGSSLPSPLSDP IPI:IPI00178185.1 GP:AB014599_1 clone for KIAA0699 has a 2-bp 2 2.858 0.183 G R.R (91%) deletion at positions 2254 and 2255 of the sequence of KIAA0699.. Homo sapiens mRNA for KIAA0704 protein, partial cds; HG02921 cDNA GP:AB014604_1 clone for KIAA0704 has a 1-bp E.AEIQKQRIEQLQRERRRV.L 2 2.719 0.100 A, G insertion at position 1212 of the sequence of KIAA0704.. E.LEYSELLDKAAQIPSPLERMV.Y 2 2.561 0.113 Homo sapiens mRNA for KIAA0709 protein, complete cds; HH01151 IPI:IPI00005707.3 GP:AB014609_1 cDNA clone for KIAA0709 has a 5-bp L.GAQLLSLASYEE.E 2 2.775 0.233 A (96%) deletion at positions 3341- 3345 of the sequence of KIAA0709.. Homo sapiens mRNA for KIAA0710 protein, complete cds; HJ00237 cDNA IPI:IPI00154861.3 GP:AB014610_1 clone for KIAA0710 has a 303-bp D.PEGVALEALPVQESVHIME.G 2 3.061 0.149 A, P (95%) insertion at position 2705 of the sequence of KIAA0710.. F.RTIPEASALGLILADSDEAS.G 2 2.627 0.157 GP:AB014732_1 Homo sapiens mRNA for SMAP-4, V.VYVISAPMSPVFGLLVDK.T 2 2.804 0.186 G Supplementary Table 1 9 complete cds; potential transmembrane protein. Homo sapiens mRNA for MOP-3, GP:AB014772_1 complete cds; similar to a D. K.DQVQLKDLLKNNSLN.E 2 2.650 0.129 O, P melanogaster nuclear protein ,Sno. Homo sapiens mRNA for MOP-4, IPI:IPI00167698.1 GP:AB014773_1 complete cds; similar to human A.GKIIPAIATTTATVSGLVALEMIK.V 2 2.426 0.190 G, O (99%) ubiqutin-activating enzyme E1. C.LANLRPLLDSGTMGTKGHTEVIV.P 2 3.080 0.230 S.NLNRQFLFRPHHIQK.P 1 2.180 0.145 2 2.588 0.166 Homo sapiens HRIHFB2063 mRNA, GP:AB015349_1 Q.LSEDILADDFHLTK.L 2 2.505 0.090 O partial cds. Homo sapiens ASY mRNA, complete GP:AB015639_1 F.RAYLESEVAISEELVQKYSN.S 2 2.402 0.153 O, P cds. I.VSVTAYIALALLSVT.I 2 3.161 0.082 Homo sapiens mRNA for nuclear IPI:IPI00030214.1 GP:AB016533_1 protein containing a WW domain R.PYPSPGAVLRANAE.A 1 1.906 0.114 P (97%) (Npw38), complete cds. Homo sapiens XRCC4 mRNA, IPI:IPI00019678.1 GP:AB017445_1 N.QTDLSGLASAAVSKDDSII.S 2 2.612 0.156 G complete cds. (99%) Drosophila melanogaster mRNA, partial cds, similar to human GP:AB018047_1 isopeptidase T-3; similar to Human D.DASRPGESILVRVICPSSRVLIFK.T 2 2.202 0.211 A, P isopeptidase T-3 (ISOT-3) in GenBank Accession Number U75362. S.LAQASAAVIGAGPYAPRLIAMLK.Q 2 2.227 0.222 Homo sapiens mRNA for KIAA0720 GP:AB018263_1 L.QLLAGAGTHGTPSAPSRSL.S 1 2.673 0.104 O, P protein, partial cds. Homo sapiens mRNA for KIAA0726 H.SLASSHRNSMIPSAATLIIVVCVGFLVL IPI:IPI00156997.1 GP:AB018269_1 2 2.492 0.121 A, P protein, complete cds. MVVL.G (91%) Y.KFTVTAYDCGKKRAADDA.E 2 2.435 0.139 Homo sapiens mRNA for KIAA0731 IPI:IPI00178373.1 GP:AB018274_1 I.KRQIEYYFSVDNLERDF.F 2 2.499 0.155 G protein, partial cds. (96%) L.RGTGGGGRTPR.R 1 2.072 0.135 Homo sapiens mRNA for KIAA0732 GP:AB018275_1 G.KLFTRIGMETFPAVAEK.V 1 3.274 0.081 G protein, partial cds. Homo sapiens mRNA for KIAA0733 GP:AB018276_1 E.RLQRELEIQK.K 1 2.339 0.103 O, P protein, partial cds. L.AHVDRISETRKLSMGSDDAA.Y 2 2.481 0.244 Homo sapiens mRNA for KIAA0734 IPI:IPI00220597.1 GP:AB018277_1 G.SASADPQEPATGAWK.P 2 2.627 0.164 G, P protein, partial cds. (91%) S.EFGLQLLRQLRDYFPATNSTAVHRLEL 3 3.530 0.098 LLK.C Homo sapiens mRNA for KIAA0738 IPI:IPI00006050.1 GP:AB018281_1 A.RYGRGRVVVTGHKVLFTVGK.L 2 2.803 0.086 A, O protein, complete cds. (97%) Homo sapiens mRNA for KIAA0746 IPI:IPI00023312.1 GP:AB018289_1 K.DDEILKVQTKEDGDVF.M 2 2.663 0.097 G protein, partial cds. (94%) Homo sapiens mRNA for KIAA0752 IPI:IPI00163245.2 GP:AB018295_1 E.DLEEHVPGQTVSEEATGV.H 2 3.627 0.118 P protein, partial cds. (95%) Homo sapiens mRNA for KIAA0761 IPI:IPI00165387.1 GP:AB018304_1 I.VVLVATEL.W 1 2.351 0.095 O protein, partial cds. (96%) Homo sapiens mRNA for KIAA0762 IPI:IPI00171473.1 GP:AB018305_1 G.SPVKMEEEIR.Q 2 3.310 0.127 P protein, partial cds. (93%) Homo sapiens mRNA for KIAA0768 IPI:IPI00021731.2 GP:AB018311_1 L.VGYGMPALIVAVSAAVDYR.S 2 2.703 0.240 A, P protein, partial cds. (94%) N.TDNIKLEVARLSTEGNLEDLK.F 2 3.230 0.201 Homo sapiens mRNA for KIAA0776 K.DERRRKATEGSGSMRGGGGGNAREY IPI:IPI00179812.1 GP:AB018319_1 2 2.394 0.110 O, P protein, partial cds. K.I (94%) L.VKYQGLVVKQLVSQSK.K 3 3.671 0.170 Q.LEVVHTLDGKEYITPAQISK.E 2 2.242 0.132 R.RKATEGSGSMRGGGGGNAREYK.I 2 2.281 0.176 Homo sapiens mRNA for KIAA0777 IPI:IPI00020728.1 GP:AB018320_1 V.EKLTPPEK.A 1 1.824 0.102 A, O protein, complete cds. (93%) Y.DFKAQTSKELSFKKGDTVYIL.R 2 2.471 0.162 Homo sapiens mRNA for KIAA0780 G.TCQVNSLSSPHVSQAQQETYLGFWIN IPI:IPI00027642.2 GP:AB018323_1 3 3.887 0.156 P protein, partial cds. SKKSQCNIF.L (95%) R.AGLAKVIPPKE.W 1 2.075 0.133 Homo sapiens mRNA for KIAA0786 IPI:IPI00029842.1 GP:AB018329_1 D.VSSSVRLMEQLVDILDAQL.Q 2 3.325 0.109 P protein, partial cds. (94%) Homo sapiens mRNA for KIAA0790 GP:AB018333_1 Q.GQEEGRLGGGLAPDTSK.S 2 2.239 0.170 G protein, partial cds. R.KNPLHKSNSED.S 1 1.879 0.085
Supplementary Table 1 10 Homo sapiens mRNA for KIAA0793 IPI:IPI00171819.1 GP:AB018336_1 G.PYQDTLEFLL.G 2 3.098 0.177 O, P protein, complete cds. (92%) Homo sapiens mRNA for KIAA0794 IPI:IPI00015796.1 GP:AB018337_1 R.SESLIDASEDSQ.L 1 2.303 0.092 A protein, partial cds. (94%) Homo sapiens mRNA for KIAA0805 protein, partial cds; hk02940 cDNA IPI:IPI00102678.1 GP:AB018348_1 clone for KIAA0805 has a 94-bp N.TELGALMITVAGL.K 2 2.426 0.220 A, P (98%) insertion at 2296 of the sequence of KIAA0805.. S.AFFSTPLNPFL.G 1 2.028 0.080 Homo sapiens mRNA for KIAA0809 protein, partial cds; hk05250 cDNA IPI:IPI00166019.1 GP:AB018352_1 clone for KIAA0809 has a 1-bp R.LVFPVTTDPLVPAG.P 2 2.632 0.111 A (95%) deletion at position 2373 of the sequence of KIAA0809.. Homo sapiens mRNA for Gab2, IPI:IPI00180242.1 GP:AB018413_1 F.ILRSGRMSGDPDVLEYYKNDHS.K 2 2.799 0.314 O complete cds. (97%) Homo sapiens DNA for immunoglobulin heavy-chain variable GP:AB019437_1 P.QAPGQGLEWMGW.F 2 3.176 0.241 G region, complete sequence, 1 of 5; 7- 81 putative. Y.TGNPTYAQGFTGR.F 2 3.579 0.427 Homo sapiens DNA for immunoglobulin heavy-chain variable IPI:IPI00140854.2 GP:AB019437_2 N.SDGSSTSYADSVK.G 2 2.417 0.272 G, O, P region, complete sequence, 1 of 5; 3- (95%) 74. R.INSDGSSTSYADSVK.G 2 3.940 0.348 S.DGSSTSYADSVK.G 2 2.555 0.286 Homo sapiens DNA for immunoglobulin heavy-chain variable GP:AB019437_3 C.EVQLVESGGGLVQPGGSLK.L 1 2.518 0.173 G, O, P region, complete sequence, 1 of 5; 3- 73. 2 5.276 0.242 K.NTAYLQMNSLK.T 1 2.990 0.236 Homo sapiens DNA for immunoglobulin heavy-chain variable GP:AB019437_5 K.YYSTSLK.T 1 1.992 0.164 G, P region, complete sequence, 1 of 5; 2- 70. L.IDWDDDKYYSTSLK.T 2 3.727 0.372 Homo sapiens DNA for immunoglobulin heavy-chain variable IPI:IPI00007893.1 GP:AB019437_6 K.KPGSSVK.V 1 1.981 0.106 G, P region, complete sequence, 1 of 5; 1- (96%) 69. K.STSTAYMELSSLR.S 1 2.176 0.113 2 3.677 0.403 R.VTITADK.S 1 1.949 0.161 Homo sapiens DNA for immunoglobulin heavy-chain variable GP:AB019437_8 C.EVQLVESGEGLVQPGGSLR.L 2 2.767 0.118 G region, complete sequence, 1 of 5; 3- 64. Homo sapiens DNA for immunoglobulin heavy-chain variable GP:AB019437_9 Q.LQESGPGLVKPSETL.S 2 3.303 0.335 G, P region, complete sequence, 1 of 5; 4- 61. R.VTISVDTSK.N 1 1.952 0.192 Y.IYYSGSTNYNPSLK.S 2 4.077 0.231 Homo sapiens DNA for immunoglobulin heavy-chain variable GP:AB019438_4 A.EVQLVQSGAEVK.K 1 3.578 0.191 G, O, P region, complete sequence, 2 of 5; 5- 51. 2 3.788 0.251 A.EVQLVQSGAEVKK.P 2 3.532 0.183 C.AEVQLVQSGAEVK.K 2 3.401 0.242 K.GLEWMGIIYPGDSDTR.Y 1 2.512 0.281 2 4.251 0.412 K.SISTAYLQWSSLK.A 1 2.859 0.301 2 3.865 0.305 M.GIIYPGDSDTR.Y 2 2.688 0.093 R.YSPSFQGQVTISADK.S 2 3.159 0.405 S.YWIGWVR.Q 1 1.867 0.153 Y.LQWSSLK.A 1 2.093 0.089 GP:AB019438_5 Homo sapiens DNA for K.AYGGTTEYAASVK.G 2 2.411 0.191 G Supplementary Table 1 11 immunoglobulin heavy-chain variable region, complete sequence, 2 of 5; 3- 49. K.GLEWVGFIR.S 2 3.238 0.295 K.SIAYLQMN.S 1 1.813 0.152 K.SIAYLQMNSLK.T 1 2.775 0.265 2 2.990 0.296 Homo sapiens DNA for immunoglobulin heavy-chain variable IPI:IPI00007854.1 GP:AB019438_9 C.EVQLVESGGVVVQPGGSLR.L 2 2.769 0.218 O region, complete sequence, 2 of 5; 3- (93%) 43. Homo sapiens DNA for immunoglobulin heavy-chain variable GP:AB019439_1 S.GSTYYNPSLK.S 1 2.420 0.171 G region, complete sequence, 3 of 5; 4- 39. S.IYYSGSTYYNPSLK.S 2 3.810 0.487 Homo sapiens DNA for immunoglobulin heavy-chain variable GP:AB019439_10 K.GLEWMGGFDPEDGETIYAQK.F 2 3.571 0.401 G, O, P region, complete sequence, 3 of 5; 1- 24. R.VTMTEDTSTDTAYMELSSLR.S 2 5.523 0.583 T.STDTAYMELSSLR.S 2 2.785 0.308 Homo sapiens DNA for immunoglobulin heavy-chain variable GP:AB019439_12 C.EVQLVESGGGLVK.P 1 3.349 0.126 A, G, O, P region, complete sequence, 3 of 5; 3- 21. 2 4.040 0.085 C.EVQLVESGGGLVKPGGSLR.L 1 4.263 1.000 2 5.607 1.000 3 4.161 0.100 E.VQLVESGGGLVKPGGSLR.L 2 3.264 0.282 Q.LVESGGGLVKPGGSLR.L 1 2.884 0.202 2 4.246 0.213 Homo sapiens DNA for immunoglobulin heavy-chain variable GP:AB019439_2 C.EVQLVESGGGLVQPRG.S 2 4.285 0.361 G, O, P region, complete sequence, 3 of 5; 3- 38 putative. K.NTLYLQMNNLR.A 1 2.305 0.181 2 3.295 0.189 Q.LVESGGGLVQPRG.S 2 3.799 0.229 Homo sapiens DNA for immunoglobulin heavy-chain variable IPI:IPI00178818.1 GP:AB019439_4 N.HSGSTNYNPSLK.S 1 2.859 0.207 G region, complete sequence, 3 of 5; 4- (96%) 34. Homo sapiens DNA for immunoglobulin heavy-chain variable GP:AB019439_8 R.VTMSVDTSK.N 1 2.152 0.334 G, O region, complete sequence, 3 of 5; 4- 28 transcribed gene. Homo sapiens DNA for immunoglobulin heavy-chain variable IPI:IPI00011586.1 GP:AB019439_9 K.ALEWLAHIFSNDEK.S 1 2.711 0.283 G region, complete sequence, 3 of 5; 2- (94%) 26. Homo sapiens DNA for immunoglobulin heavy-chain variable GP:AB019440_2 M.TTDTSTSTAYMELR.S 2 4.612 0.490 G, O, P region, complete sequence, 4 of 5; 1- 18. R.VTMTTDTSTSTAYMELR.S 2 5.283 0.529 Homo sapiens DNA for immunoglobulin heavy-chain variable GP:AB019440_6 C.QVQLVESGGGLVKPGGSLR.L 1 3.967 0.164 G, O, P region, complete sequence, 4 of 5; 3- 11. 2 3.218 1.000 Homo sapiens DNA for immunoglobulin heavy-chain variable GP:AB019440_7 N.SGSIGYADSVK.G 2 2.501 0.354 G region, complete sequence, 4 of 5; 3- 9. Homo sapiens DNA for immunoglobulin heavy-chain variable IPI:IPI00007861.1 GP:AB019441_4 K.NQFSLQ.L 1 1.958 0.105 G, P region, complete sequence, 5 of 5; 6- (99%) 1. R.GLEWLGR.T 1 1.831 0.267 R.ITINPD.T 1 1.955 0.101
Supplementary Table 1 12 R.ITINPDTSK.N 1 2.274 0.166 S.VSSNSAAWNWIR.Q 2 3.451 0.349 Homo sapiens mRNA for S.RHNTAVSQLTKAKEALIAASETLKERK. GP:AB019987_1 chromosome-associated polypeptide- 2 2.271 0.214 O A C, complete cds. T.NKLKENYQMLTLGGDAELELV.D 2 2.401 0.144 Homo sapiens mRNA for peptide GP:AB020598_1 V.PGERQPLLPRGA.R 2 2.927 0.180 P transporter 3, complete cds; putative. Xenopus laevis mRNA for human GP:AB020609_1 Ku80 autoantigen homologue, partial A.LSALIHALDEMDMVAIVR.Y 2 2.567 0.088 P cds. Homo sapiens mRNA for KIAA0820 GP:AB020627_1 L.GIIGDISTATVSTPA.P 2 2.697 0.141 O, P protein, partial cds. R.EREGKTKDQVLLL.I 1 1.860 0.095 Homo sapiens mRNA for KIAA0822 IPI:IPI00183538.1 GP:AB020629_1 I.NAAIIEITTNHSVM.E 1 2.188 0.233 G, O protein, complete cds. (94%) N.DFSSLLTMDLGRVDTF.N 1 2.244 0.129 Homo sapiens mRNA for KIAA0830 GP:AB020637_1 E.ELVSIPWKVLKV.V 2 2.707 0.084 G protein, partial cds. Homo sapiens mRNA for KIAA0846 IPI:IPI00171874.1 GP:AB020653_1 F.HDKAAKDKGFAKWENEKPRVHA.G 2 3.242 0.110 G protein, complete cds. (93%) Homo sapiens mRNA for KIAA0851 IPI:IPI00022275.1 GP:AB020658_1 A.CDDGADDVLTIDRVSTEVTLAVKKD.V 2 3.264 0.245 P protein, complete cds. (97%) Homo sapiens mRNA for KIAA0865 GP:AB020672_1 N.QNGVLDFFFQK.P 2 2.782 0.164 P protein, partial cds. Homo sapiens mRNA for KIAA0888 IPI:IPI00002661.1 GP:AB020695_1 Q.LDQFTQSAEKA.V 2 2.973 0.129 G, O, P protein, partial cds. (94%) R.PSESSEEFLEEEPE.Q 2 2.779 0.131 Homo sapiens mRNA for KIAA0909 GP:AB020716_1 R.QALSIPDSLGRLPLSVAH.S 1 2.062 0.118 G protein, partial cds. Homo sapiens mRNA for KIAA0911 protein, complete cds; hj05129 cDNA IPI:IPI00007257.1 GP:AB020718_1 clone for KIAA0911 has a 1-bp C.SYEIITPDVPFTVDK.D 2 2.644 0.151 O, P (93%) deletion at position 1783 of the sequence of KIAA0911. P.FGRKKETILCSSDKTDMNR.H 2 2.247 0.123 Homo sapiens mRNA for KIAA0912 protein, partial cds; hk03560 cDNA IPI:IPI00016653.1 GP:AB020719_1 clone for KIAA0912 has a 1-bp K.ALETQIQAL.K 1 2.186 0.195 A, O, P (93%) insertion at position 3620 of the sequence of KIAA0912.. K.KTLDCGSQTDQVTTSDVIS.K 2 2.608 0.095 Homo sapiens mRNA for KIAA0917 protein, partial cds; hk07974 cDNA IPI:IPI00178892.1 GP:AB020724_1 clone for KIAA0917 has a 2104-bp I.YDRFGQDIISPLLSVKELR.D 2 2.342 0.152 A, O, P (97%) insertion at position 1476 of the sequence of KIAA0917.. K.IMSKTTLDKSLLDIISDPDAG.T 2 2.701 0.144 L.HLLLHSDRDPIPDV.P 1 2.101 0.150 V.MEGVKNLVLKQQNLPVTR.I 2 2.556 0.239 Homo sapiens gene for DMBT1, exon IPI:IPI00180285.1 GP:AB020851_1 F.RAFHFLNRFPSVYLRCKM.V 2 2.465 0.109 O, P 40, complete cds. (98%) I.RFISDHSITRRGFR.A 2 2.595 0.209 Homo sapiens mRNA for immunoglobulin heavy chain variable IPI:IPI00180166.1 GP:AB021509_1 -.EVQLVESGGGLVKPGGSLK.L 1 3.395 0.183 G, O region (IgM), partial cds, clone (91%) kgpbmc17. 2 5.057 0.283 K.NTLYLQMNSLK.T 1 3.128 0.274 Q.LVESGGGLVKPGGSLK.L 2 2.509 0.178 Homo sapiens mRNA for immunoglobulin heavy chain variable IPI:IPI00180166.1 GP:AB021517_1 G.TTDYAAPVK.G 1 1.928 0.251 G, O, P region (IgM), partial cds, clone (93%) kgpbmc6. K.SKTDGGTTDYAAPVK.G 2 4.390 0.343 K.TDGGTTDYAAPVK.G 1 2.263 0.310 2 3.520 0.421 S.KTDGGTTDYAAPVK.G 2 4.726 0.424 T.DYAAPVK.G 1 2.388 0.211 Homo sapiens mRNA for immunoglobulin heavy chain variable GP:AB021518_1 -.EVQLVESGGGVVQPGGSLR.L 2 2.661 0.158 G, O, P region (IgM), partial cds, clone kgpbmc61. Supplementary Table 1 13 Q.LVESGGGVVQPGGSLR.L 2 4.373 0.341 Homo sapiens mRNA for immunoglobulin heavy chain variable GP:AB021522_1 -.QVQLVESGGGLVKPGGSLK.L 1 2.878 0.248 G, O region (IgM), partial cds, clone kgpbmc79. 2 4.809 0.293 Homo sapiens mRNA for anti- Entamoeba histolytica immunoglobulin GP:AB022650_1 S.WGQGTLVTVSAASTK.G 2 3.076 0.267 G gamma heavy chain (V-CH1 region), partial cds; V-CH1 region. Homo sapiens mRNA for anti- Entamoeba histolytica immunoglobulin IPI:IPI00003457.1 GP:AB022651_1 D.GWLAWYQQK.P 2 2.250 0.143 G, P kappa light chain (V-C region), partial (91%) cds, clone:A235-L1; V-C region. D.GWLAWYQQKPGK.P 2 3.759 0.266 K.ASNLHSGVPSR.F 2 2.644 0.089 Homo sapiens mRNA for anti- Entamoeba histolytica immunoglobulin IPI:IPI00004618.1 GP:AB022652_1 gamma heavy chain (V-CH1 region), K.GVFHYWGQGTLVTVSSASTK.G 2 2.303 0.131 G (95%) partial cds, clone:B220-H2; V-CH1 region. R.RKGVFHYWGQGTLVTVSSASTK.G 2 2.627 0.135 Homo sapiens mRNA for anti- Entamoeba histolytica immunoglobulin GP:AB022655_1 gamma heavy chain (V-CH1 region), P.GTVVTVSSASTK.G 1 1.949 0.192 G partial cds, clone:E244-H1; V-CH1 region. Homo sapiens mRNA for anti- Entamoeba histolytica immunoglobulin IPI:IPI00160257.2 GP:AB022656_1 A.ASTLQSGVPSR.F 2 2.577 0.211 A, G, O, P kappa light chain (V-C region), partial (92%) cds, clone:E244-L1; V-C region. L.LIYAASTLQSGVPSR.F 2 2.960 0.305 Q.KPGKAPKLLIYAASTLQSGVPSRFSGS 2 2.500 0.113 GSGTEF.T R.ASQGISSYLAWYQQKPGK.A 2 4.906 0.206 S.TLQSGVPSR.F 1 1.931 0.093 Y.AASTLQSGVPSR.F 1 2.245 0.210 2 3.689 0.274 Homo sapiens mRNA for BEC1, GP:AB022696_1 A.LQALYFVCSGSMEVLKGGTVLA.I 2 2.407 0.256 G, O, P complete cds. G.IDTTELLQSLPDELRADIAMHLHKEV.L 2 2.570 0.216 L.AVEVLFILDIVL.N 2 2.876 0.110 Homo sapiens mRNA for KIAA0924 GP:AB023141_1 V.EPPKRKKRATKEPK.A 2 3.123 0.090 O protein, complete cds. Homo sapiens mRNA for KIAA0941 IPI:IPI00007145.1 GP:AB023158_1 S.EFSSGEIQMKSK.P 2 2.628 0.163 A protein, complete cds. (94%) Homo sapiens mRNA for KIAA0942 IPI:IPI00178366.1 GP:AB023159_1 D.YEKKPNVFK.L 1 1.991 0.125 P protein, partial cds. (91%) Homo sapiens mRNA for KIAA0944 IPI:IPI00103647.1 GP:AB023161_1 A.LLKFADDQGYGGSKLSSLSLGQGQ.G 2 2.464 0.101 O, P protein, partial cds. (96%) D.ECDADLAGA.L 2 2.401 0.112 D.ITKDQSETQLLFDNILLTQSR.S 2 2.458 0.104 S.YPSPNFPVSVLQNGVKMTNEAPK.G 2 3.191 0.085 Homo sapiens mRNA for KIAA0960 IPI:IPI00175574.1 GP:AB023177_1 S.RCSKSCGSGVKVR.S 1 2.460 0.198 G protein, partial cds. (97%) Homo sapiens mRNA for KIAA0966 IPI:IPI00007250.1 GP:AB023183_1 G.NFTKPEMKVNFLKPNLK.V 2 2.486 0.108 A protein, complete cds. (94%) V.SLSATGPQFLSVEPAH.S 1 2.037 0.151 Homo sapiens mRNA for KIAA0967 IPI:IPI00007160.1 GP:AB023184_1 C.TNHIQETAPK.Y 1 2.053 0.092 G, O, P protein, complete cds. (94%) G.AKYGISQVINSK.L 1 2.307 0.107 2 2.966 0.150 V.CFVPKDPLDLLKED.P 2 2.872 0.126 Homo sapiens mRNA for KIAA0968 IPI:IPI00098624.1 GP:AB023185_1 Y.LDAGGIPR.T 1 2.051 0.096 G protein, partial cds. (97%) Homo sapiens mRNA for KIAA0975 GP:AB023192_1 K.ELDTVEVLK.A 1 1.880 0.094 O protein, partial cds. Homo sapiens mRNA for KIAA0978 IPI:IPI00217537.1 GP:AB023195_1 D.GLGDASQLPVAPTGDQPCQAL.P 2 2.485 0.231 O, P protein, partial cds. (92%) R.AVCLSMPGSSVEATNPLVMQLLQGSL 3 3.606 0.212 PLEKVL.P Homo sapiens mRNA for KIAA0979 IPI:IPI00217628.1 GP:AB023196_1 R.HDVIVSIVTAAKKDILLVNDH.L 2 2.750 0.130 O protein, partial cds. (98%) Supplementary Table 1 14 Homo sapiens mRNA for KIAA0986 IPI:IPI00045400.1 GP:AB023203_1 N.LHCQLEL.E 1 2.077 0.127 G, P protein, partial cds. (92%) T.TSDLQSEVIRHYSKQAIK.Q 2 2.328 0.190 Homo sapiens mRNA for KIAA0987 GP:AB023204_1 L.LPEAPPKKFLTL.G 1 2.599 0.149 G protein, partial cds. Homo sapiens mRNA for KIAA0988 IPI:IPI00186944.1 GP:AB023205_1 I.LKALTYDEKRGACSVGTNVR.D 2 2.537 0.180 P protein, complete cds. (96%) Homo sapiens mRNA for KIAA0998 L.PNSNLWTMNNGAGCRISSATASGQKP. IPI:IPI00007914.4 GP:AB023215_1 2 2.453 0.117 A, P protein, partial cds. T (99%) R.PLSASDAEM.K 1 1.804 0.083 Homo sapiens mRNA for KIAA0999 IPI:IPI00032263.2 GP:AB023216_1 E.LGIHPYGHQPTAAFSKNK.V 2 2.918 0.138 A, P protein, partial cds. (91%) R.IQPSSPPPNHPNNHLF.R 2 2.635 0.115 V.RYLSMRR.H 1 2.161 0.115 Homo sapiens mRNA for KIAA1007 IPI:IPI00032299.2 GP:AB023224_1 R.IFIARMLAHTPQQKGWPM.Y 2 2.884 0.116 G, P protein, partial cds. (98%) Homo sapiens mRNA for KIAA1009 protein, complete cds; hj03795 cDNA clone for KIAA1009 has a 87-bp GP:AB023226_1 D.EDFQSIEFQVEQAHAK.A 1 2.210 0.137 G insertion at position 1423 and a 35-bp deletion at position between 2301 and 2337 of the sequence of KIAA1009.. Homo sapiens mRNA for KIAA1012 protein, complete cds; hj06464 cDNA IPI:IPI00007253.1 GP:AB023229_1 clone for KIAA1012 has a 1-bp of H.PLQLEQSSDPSN.S 2 3.141 0.106 G, P (97%) insertion (T) at position 2094 of the sequence of KIAA1012.. R.DICKNMVLAERCVLLSAELLK.S 2 2.492 0.157 Homo sapiens mRNA for KIAA1014 protein, partial cds; hk02388 cDNA GP:AB023231_1 clone for KIAA1014 has a 975-bp P.VLYSQSAIATGHQAAGIGNQATGI.G 2 2.670 0.129 P insertion at position 980 of the sequence of KIAA1014.. I.FSHVGQLTGMYR.Y 2 2.659 0.098 L.KVECALRDLILSDYAKKNNVN.T 2 2.630 0.090 L.RGIVPLLERWL.G 1 2.111 0.099 P.DGVEPLLKGTELYTDTTAAGISLLFAPK. 3 3.659 0.102 P Homo sapiens rec mRNA, complete A.MFSVSLSSLFGYHCWLVSKNKSTLEAF IPI:IPI00008896.1 GP:AB023584_1 3 3.536 0.227 P cds; reduced expression in cancer. RSPVFR.H (95%) V.GFSNYKFFLLFLAYSLL.Y 2 2.652 0.157 Homo sapiens hGnT-IV-H mRNA for alpha-1,3-D-mannoside beta-1,4-N- GP:AB024729_1 T.LEFSKL.G 1 2.023 1.000 G acetylglucosaminyltransferase IV- homologue, complete cds. Homo sapiens mRNA for MALT1, IPI:IPI00216846.1 GP:AB026118_1 L.NVFLLDMCRKRND.Y 1 2.017 0.157 A complete cds. (91%) T.TDQPLAKDKVALLIGNMNYR.E 2 2.325 0.103 Homo sapiens mRNA for GCM motif GP:AB026493_1 protein, complete cds; glial cells K.LPQNVKKTDW.F 2 2.656 0.119 G missing. Homo sapiens mRNA for vascular IPI:IPI00009851.1 GP:AB026893_1 E.ALPKDSFIALVMADDLDSGHNGL.V 2 2.636 0.106 G, P cadherin-2, complete cds. (91%) Q.VSEEVPSGTVIGK.L 2 2.288 0.103 Homo sapiens mRNA for cyclin-E binding protein 1, complete cds; contains RCC1 like domains and IPI:IPI00008821.1 GP:AB027289_1 V.GRKFPSTTTPQI.V 2 2.451 0.137 G, P homologous to the E6-AP carboxyl (95%) terminus (hect) domain; similar to KIAA0032. V.HQLLAGSGGAR.T 2 2.874 0.094 Homo sapiens mRNA for anti TNF- alpha antibody light-chain Fab IPI:IPI00003457.1 GP:AB027436_1 K.HKLYACEVTHQGLSSPVTK.S 2 4.067 0.306 G, O, P fragment, partial cds, clone:1F8- (97%) gk10L. K.LYACEVTHQGL.S 2 2.704 0.268 K.LYACEVTHQGLSSPVTK.S 2 4.893 0.455 L.SKADYEKHKLYACEVTHQGLSSPVTK. 2 2.696 0.207 S R.ASQSISSWLAWYQQK.P 2 2.543 0.213 R.ASQSISSWLAWYQQKPGK.A 2 4.122 0.226 Homo sapiens mRNA for anti TNF- IPI:IPI00003457.1 GP:AB027438_1 alpha antibody light-chain Fab -.DIELTQSPSTLSASVGDR.V 2 3.221 0.346 G, P (92%) fragment, partial cds, clone:1F8- Supplementary Table 1 15 gk20L. Homo sapiens mRNA for anti TNF- alpha antibody heavy-chain Fab GP:AB027439_1 Q.LVQSGGGLVQPGGSLR.L 1 1.844 0.145 G, O fragment, partial cds, clone:1F8- mk26H. 2 3.390 0.265 Homo sapiens mRNA for anti TNF- alpha antibody light-chain Fab IPI:IPI00024136.1 GP:AB027440_1 R.SNWPLTFGGGTK.V 1 2.328 0.284 G fragment, partial cds, clone:1F8- (95%) mk26L. R.SNWPLTFGGGTKV.E 2 2.978 0.155 Homo sapiens mRNA for anti HBs GP:AB027442_1 antibody light-chain Fab fragment, K.RLIYAASSLQSGVPSR.F 2 3.072 0.305 G partial cds, clone:303-15L. Homo sapiens mRNA for anti HBs GP:AB027443_1 antibody heavy-chain Fab fragment, -.QIQLVQSGGGLVK.P 1 2.287 0.165 G, O, P partial cds, clone:305-51H. -.QIQLVQSGGGLVKPGGSLR.L 2 4.213 1.000 G.YWFDPWGQGTLVTVSSASTK.G 2 4.184 0.155 Q.LVQSGGGLVKPGGSLR.L 2 3.662 0.204 W.FDPWGQGTLVTVSSASTK.G 1 2.667 0.350 2 3.817 0.463 Y.WFDPWGQGTLVTVSSASTK.G 2 5.003 0.097 Homo sapiens mRNA for anti HBs GP:AB027446_1 antibody light-chain Fab fragment, -.DIELTQSPGTLSLSPGER.A 2 4.292 0.193 G partial cds, clone:308-09L. Homo sapiens mRNA for anti HBs GP:AB027447_1 antibody heavy-chain Fab fragment, A.THYNPSLK.S 1 1.994 0.136 G partial cds, clone:308-19H. Homo sapiens mRNA for anti HBs GP:AB027448_1 antibody light-chain Fab fragment, A.GVETTKPSK.Q 2 2.636 0.130 A, G, O, P partial cds, clone:308-19L. I.NRPSGVPDR.F 2 2.471 0.127 K.ADGSPVKAGVETTKPSK.Q 2 3.727 0.354 3 4.082 0.304 K.AGVETTKPSK.Q 1 2.962 0.249 2 3.342 0.176 K.AGVETTKPSKQSNNK.Y 2 2.925 0.227 K.AGVETTKPSKQSNNKYAASSYLSLTPE 3 5.146 0.410 QWK.S K.ANPTVTLFPPSSEELQA.N 1 2.672 0.399 K.ANPTVTLFPPSSEELQAN.K 1 2.633 0.167 K.ANPTVTLFPPSSEELQANK.A 2 3.616 0.373 L.TQPPSVSGAPGQR.I 2 2.480 0.302 N.RPSGVPDRFSGSK.S 2 2.638 0.199 Q.PPSVSGAPGQR.I 1 2.586 0.241 Q.SVLTQPPSVSGAPGQR.I 2 3.733 0.378 S.VLTQPPSVSGAPGQR.I 2 2.384 0.248 T.VTVLGQPK.A 1 2.408 0.211 2 2.535 0.124 Homo sapiens mRNA for KIAA1022 GP:AB028945_1 E.GGENVDTCTVYADGQAFMVDKPPV.P 2 3.236 0.231 A, G, O, P protein, partial cds. Homo sapiens mRNA for KIAA1029 GP:AB028952_1 P.EPTKQPPYQLRPSLF.V 1 2.251 0.094 A, G protein, complete cds. S.PASERRPLGNFTAPPTYTETLSTA.P 2 2.420 0.123 Homo sapiens mRNA for KIAA1033 IPI:IPI00164930.1 GP:AB028956_1 R.PSSPHGLVGAVSVG.G 1 2.275 0.107 A protein, partial cds. (95%) Homo sapiens mRNA for KIAA1039 IPI:IPI00010429.1 GP:AB028962_1 L.PFTDGDAQQLQR.K 2 2.688 0.113 A protein, partial cds. (91%) Homo sapiens mRNA for KIAA1043 GP:AB028966_1 A.GFMLIGSDVKLNSPSSLI.G 1 2.164 0.153 A, G, O protein, partial cds. I.DKLKMAAIDEKVQAVHNLK.M 2 2.744 0.138 R.NTCFSPDHKQPQPGTAGG.M 2 2.608 0.137 Homo sapiens mRNA for KIAA1054 IPI:IPI00173947.1 GP:AB028977_1 D.EYALLTRNVERDKYA.N 2 2.596 0.105 A, G protein, partial cds. (97%) F.VNFLGTLAVLPGNIVSALLMDR.I 2 2.526 0.113 Homo sapiens mRNA for KIAA1058 IPI:IPI00216409.1 GP:AB028981_1 Y.KFPSTFYEGRADMCAAL.C 2 2.704 0.089 P protein, partial cds. (98%) Homo sapiens mRNA for KIAA1065 IPI:IPI00182965.1 GP:AB028988_1 T.KPVSVSGSFEL.F 2 2.707 0.092 A protein, complete cds. (91%)
Supplementary Table 1 16 Homo sapiens mRNA for KIAA1069 IPI:IPI00175416.1 GP:AB028992_1 D.EDSADEIEDECKFK.L 2 2.420 0.104 A, G, O protein, partial cds. (94%) I.QQQRKIAQYLK.G 1 1.953 0.135 V.ISGQQLPKPPDSMFGDR.G 1 2.145 0.128 Homo sapiens mRNA for KIAA1079 IPI:IPI00217391.1 GP:AB029002_1 S.KTTSNLLSSK.P 2 2.289 0.111 A, P protein, complete cds. (92%) W.NALKPNTNSRDSSNNAAF.P 1 2.296 0.223 Homo sapiens mRNA for KIAA1084 IPI:IPI00007170.1 GP:AB029007_1 E.NLIPDSLLTSAQKIISSSPNK.K 2 2.536 0.202 A, G, O, P protein, complete cds. (93%) N.EKSQKCLLIGKK.R 1 1.951 0.210 S.KIVENEK.S 1 1.904 0.107 Homo sapiens mRNA for KIAA1091 R.LVTISPNNKPKLNTGQIQESIGEAVNGI IPI:IPI00010335.1 GP:AB029014_1 2 2.526 0.147 A protein, partial cds. VKH.F (98%) Homo sapiens mRNA for KIAA1092 IPI:IPI00183756.1 GP:AB029015_1 A.KIDIK.S 1 1.938 1.000 O protein, partial cds. (97%) L.PELAMVRFVVLDDDYIGDE.F 2 2.492 0.167 Homo sapiens mRNA for KIAA1096 GP:AB029019_1 E.NSPNVR.E 1 1.880 0.101 A, G, P protein, partial cds. L.APPSLAQQQGFQPGLSQPTSV.Q 2 2.572 0.175 Q.SSSLTSVPPTTFSLTF.K 2 2.675 0.160 Homo sapiens mRNA for KIAA1100 GP:AB029023_1 R.RASAPAGGSPRMLHP.A 1 2.481 0.132 G protein, complete cds. Homo sapiens mRNA for KIAA1117 protein, partial cds; hk07169 cDNA clone for KIAA1117 has a 118-bp IPI:IPI00029407.2 GP:AB029040_1 C.ACKMHPQWIGLITSTLPYMGKVLQR.V 2 2.251 0.219 A, G, O, P deletion at the position between 3582 (93%) and 3701 of the sequence of KIAA1117.. S.VYSVHALTLLSEVLAHL.L 2 3.390 0.162 Homo sapiens HCR (a-helix coiled-coil I.RGLIARKLALAQLRQESCPLPPPVTDVS GP:AB029331_1 rod homologue) mRNA, complete cds; 3 3.975 0.129 A LEL.Q a-helix coiled-coil rod homologue. Homo sapiens mRNA for SEMB, IPI:IPI00149097.1 GP:AB029394_1 M.IPWPASDRKKSECAFKKK.S 2 2.605 0.161 O, P complete cds. (93%) Homo sapiens SerRSmt mRNA for IPI:IPI00221025.1 GP:AB029948_1 mitochondrial seryl-tRNA synthetase, A.RVLHMVGDKPVFSF.Q 2 2.480 0.122 A, P (96%) complete cds. Q.ELRQLQEQIRSLEEEK.A 2 3.087 0.100 Homo sapiens mRNA for immunoglobulin gamma heavy chain, partial cds, V and CH1 region, specific GP:AB030639_1 N.NTLYLQMNSLTA.E 2 3.269 0.154 G, O, P for Entamoeba histolytica; V and CH1 region, specific for Entamoeba histolytica. Homo sapiens mRNA for H-REV107 IPI:IPI00005278.2 GP:AB030815_1 P.VEVIISSAKEMVGQKMKYSI.V 2 2.980 0.105 P protein-related protein, complete cds. (93%) Homo sapiens mRNA for transcription I.RSARGNNPNGREAKMICFKSVAKTPYD GP:AB030834_1 3 3.911 0.292 G factor Elongin A2, complete cds. TSRRQ.E Homo sapiens VRK3 mRNA for IPI:IPI00009291.1 GP:AB031052_1 vaccinia related kinase 3, complete D.SSESEDTLSSSERSKGSGSRPPTPK.S 2 2.492 0.149 G, P (94%) cds. K.HVLSERSVLQVACRLLDALE.F 2 2.864 0.157 Homo sapiens STG mRNA, complete GP:AB031481_1 G.LSPEASLLHQDSESRR.L 2 3.035 0.102 A, G, O cds. P.QPALDPR.S 1 2.104 0.181 Homo sapiens BAZ1A mRNA for GP:AB032252_1 bromodomain adjacent to zinc finger R.EMPLLHRKP.F 1 2.493 0.149 O, P domain 1A, complete cds. Homo sapiens BNPI mRNA for brain- specific Na-dependent inorganic IPI:IPI00177889.1 GP:AB032436_1 V.LVQYSGWSSVFYVYGSF.G 2 2.424 0.100 A, G phosphate cotransporter, complete (98%) cds. Y.SHSKGVAISFLVLAVG.F 2 3.344 0.172 Homo sapiens mRNA for KIAA1121 GP:AB032947_1 protein, partial cds; Start codon is not C.IAYPFNAK.Q 1 2.057 0.088 P identified.. Homo sapiens mRNA for KIAA1127 IPI:IPI00185259.1 GP:AB032953_1 protein, partial cds; Start codon is not G.LAEGNKLLAPVALA.V 1 2.290 0.105 G (97%) identified.. I.NRLRQVTTNGEIC.L 1 2.175 0.093 Homo sapiens mRNA for KIAA1130 IPI:IPI00166613.1 GP:AB032956_1 protein, partial cds; Start codon is not K.QVSLLASGPEAQ.Q 1 2.182 0.159 O, P (94%) identified.. 2 2.769 0.138 Supplementary Table 1 17 Homo sapiens mRNA for KIAA1135 GP:AB032961_1 protein, partial cds; Start codon is not Q.YKDIYTALKK.G 2 2.605 0.126 A identified.. Homo sapiens mRNA for KIAA1185 GP:AB033011_1 protein, partial cds; Start codon is not T.HELRAVKGPLLYCAR.P 2 2.830 0.141 A identified.. Homo sapiens mRNA for KIAA1193 IPI:IPI00008206.1 GP:AB033019_1 protein, partial cds; Start codon is not A.LYELVK.C 1 1.868 0.132 A, P (95%) identified.. L.PEGEAVK.D 1 1.836 0.139 Homo sapiens mRNA for KIAA1194 K.SSVLGEFGTIPLVLCADLNSLPDSGVV. IPI:IPI00008205.1 GP:AB033020_1 protein, partial cds; Start codon is not 2 2.446 0.186 G, O E (93%) identified.. S.LTHLTALHLSDNSLSRIPSDI.A 2 2.568 0.152 Homo sapiens mRNA for KIAA1197 A.ASGGSGAGGGGGGGGGGGSGSGGG IPI:IPI00182021.1 GP:AB033023_1 protein, partial cds; Start codon is not 2 2.766 0.080 P GST.G (93%) identified.. G.GGGGGGGGSGSGGGGSTGGGGGTA 2 3.119 0.183 GGGTQ.S Q.GTFLVGQPSPQTSGK.Q 1 1.835 0.103 Homo sapiens mRNA for KIAA1199 IPI:IPI00178548.1 GP:AB033025_1 protein, partial cds; Start codon is not P.MPKKLFGSQLK.T 2 2.450 0.114 O, P (99%) identified.. R.NTFDHCLGLLVKSGTLLP.S 2 3.079 0.087 T.NVNSTILNLEDNVQSWK.P 2 2.452 0.128 Homo sapiens mRNA for KIAA1203 GP:AB033029_1 protein, partial cds; Start codon is not G.RAPLAVMEGVFK.D 1 1.844 0.095 A identified.. Homo sapiens mRNA for KIAA1206 IPI:IPI00022513.2 GP:AB033032_1 protein, partial cds; Start codon is not P.QFVVQMGNVQLALGPVQY.E 2 2.903 0.141 G (95%) identified.. Homo sapiens mRNA for KIAA1209 IPI:IPI00008173.2 GP:AB033035_1 protein, partial cds; Start codon is not H.VYDNISYEDLKLMVA.K 1 2.090 0.086 P (97%) identified.. V.RPKSTPELAFTKRQAGHSK.G 2 2.385 0.102 Homo sapiens mRNA for KIAA1210 IPI:IPI00010063.2 GP:AB033036_1 protein, partial cds; Start codon is not V.QQQVPTSSVGTSIKQ.S 2 3.274 0.197 O (94%) identified.. Homo sapiens mRNA for KIAA1224 GP:AB033050_1 protein, partial cds; Start codon is not K.TMSPSQMIMPN.V 2 2.687 0.103 G identified.. Homo sapiens mRNA for KIAA1226 IPI:IPI00025564.2 GP:AB033052_1 protein, partial cds; Start codon is not L.KKKECKDRGFEYDGK.I 2 2.555 0.120 G, P (99%) identified.. Y.KDGSPIADDLLE.K 2 2.408 0.178 Homo sapiens mRNA for KIAA1228 IPI:IPI00159900.2 GP:AB033054_1 protein, partial cds; Start codon is not N.DGLSSALLILYLDSAR.N 2 2.559 0.130 P (97%) identified.. Homo sapiens mRNA for KIAA1229 GP:AB033055_1 protein, partial cds; Start codon is not C.ENLLHKNNQITKTK.N 2 2.287 0.162 A, O identified.. E.KEDLPRCTSESHLSCLK.Q 2 2.220 0.172 Homo sapiens mRNA for KIAA1237 GP:AB033063_1 protein, partial cds; Start codon is not T.ASLVTGPIAVQTTAGK.Q 2 2.930 0.082 O identified.. Homo sapiens mRNA for KIAA1239 GP:AB033065_1 protein, partial cds; Start codon is not D.ENGAIFSLIV.M 2 2.418 0.116 O, P identified.. I.SPNGKLGIIA.R 1 2.202 0.135 Homo sapiens mRNA for KIAA1244 IPI:IPI00179164.1 GP:AB033070_1 protein, partial cds; Start codon is not D.VQDQVVTSIGELVEV.C 1 2.358 0.122 A, O, P (93%) identified.. I.YAVVHLL.L 1 2.186 0.128 V.FANAATSYIMCLMKFVK.G 2 2.549 0.089 Homo sapiens mRNA for KIAA1250 IPI:IPI00033429.1 GP:AB033076_1 protein, partial cds; Start codon is not G.LDQSMLPQYCTTIKK.A 1 2.058 0.084 A, P (94%) identified.. L.LRNPKDGRLLYRPNKAGETPYNIDCSH 3 3.979 0.124 QK.S Homo sapiens mRNA for KIAA1263 IPI:IPI00008087.1 GP:AB033089_1 protein, partial cds; Start codon is not E.NKYCGLGRHCVTSR.E 2 2.222 0.179 A, P (98%) identified.. G.KDLFDCTLYVLLKYDDF.N 2 2.834 0.136 V.ELSSGKVKMIKSLKEPL.K 2 2.641 0.129 Supplementary Table 1 18 Homo sapiens mRNA for KIAA1271 K.VSASTVPTDGSSRNEETPAAPTPAGAT GP:AB033097_1 protein, partial cds; Start codon is not 3 4.187 0.227 O GGSSAWLDSSS.E identified.. Homo sapiens mRNA for KIAA1280 protein, partial cds; Start codon is not identified.; hh03711 cDNA clone for GP:AB033106_1 KIAA1280 has 11-bp, 1003-bp and L.EYTEEEVLEMERKEE.Q 2 3.487 0.244 O 1247-bp insertions after the positions 1451, 1734 and 2253 of the sequence of KIAA1280, respectively.. Homo sapiens mRNA for KIAA1283 protein, partial cds; Start codon is not identified.; hh05359 cDNA clone for IPI:IPI00070849.2 GP:AB033109_1 S.WISTSKMGEPVASAHTAK.I 2 2.204 0.126 O, P KIAA1283 has a 2-bp deletion at the (97%) position 2823 and 2824 of the sequence of KIAA1283.. T.VQIKAELTPKDNIYTSEVVSQRG.L 2 3.661 0.219 W.VGEAVALSTSQGLGIAEP.S 2 2.760 0.188 Homo sapiens mRNA for KIAA1284 protein, partial cds; Start codon is not identified.; hh09454 cDNA clone for IPI:IPI00008057.1 GP:AB033110_1 D.SAFCQIENVPRLDHFFNLFFQR.A 3 3.833 0.130 G KIAA1284 has a 2236-bp insertion (93%) after the position 1329 of the sequence of KIAA1284.. Homo sapiens mRNA for KIAA1287 protein, partial cds; Start codon is not identified.; hh13365 cDNA clone for IPI:IPI00021705.1 GP:AB033113_1 L.PTEEEKANGVNPDSLLR.N 2 2.627 0.092 G KIAA1287 has a 1-bp insertion after (97%) the position 3598 of the sequence of KIAA1287.. Homo sapiens mRNA for KIAA1288 protein, partial cds; Start codon is not identified.; hh13551 cDNA clone for IPI:IPI00068470.2 GP:AB033114_1 KIAA1288 has a nucleotide D.KHMAISRQLSTEQAV.L 1 2.647 0.113 G, O (97%) substitution at the position 1973 (C- T; nonsense mutation) of the sequence of KIAA1288.. K.KGHEIEK.K 2 2.654 0.096 Homo sapiens mRNA for KIAA1291 protein, partial cds; Start codon is not identified.; hj08227 cDNA clone for IPI:IPI00185404.1 GP:AB033117_1 Q.IYEALR.P 1 1.977 0.121 A KIAA1291 has a 2-bp deletion at the (97%) position 2265 and 2266 of the sequence of KIAA1291.. Homo sapiens hCCC6 mRNA for A.NVCGCAVSLLGLVESVLDVFGADATGP GP:AB033284_1 cation chloride cotransporter 6, 3 3.859 0.087 A, P S.G complete cds. R.PQLLLLVGNPRGALPLL.R 2 2.721 0.156 Homo sapiens mRNA for pendrin-like GP:AB033288_1 I.LLNLDLGLVVAV.I 2 2.495 0.107 O protein 1, complete cds; pendrin L1. V.PPVAPNTQLFSKLVGSAFTIA.V 2 2.506 0.100 Homo sapiens CYP4F12 L mRNA for IPI:IPI00185342.1 GP:AB035131_1 G.GLWLRVEPLNVGLQ.- 2 3.363 0.202 O, P cytochrome P450, complete cds. (97%) Homo sapiens NDST4 mRNA for N- R.LTLSLDRYILVDIDDIFVGKEGTRMNVK IPI:IPI00021733.1 GP:AB036429_1 deacetylase/N-sulfotransferase 4, 2 2.539 0.150 A DVK.A (96%) complete cds. Homo sapiens GPBP, DINB1 genes IPI:IPI00218100.1 GP:AB036934_2 for Thr/Ser kinase, DINB1, partial cds; Y.KDDLLLRMGFNDNK.A 1 2.549 0.123 G (98%) other name:POLK. Homo sapiens mRNA for KIAA1297 GP:AB037718_1 protein, partial cds; Start codon is not F.NHVEAQ.V 1 2.073 0.120 A, O identified.. P.QHAGVYKSVIANKLGKAA.C 2 2.420 0.232 Homo sapiens mRNA for KIAA1300 IPI:IPI00008140.2 GP:AB037721_1 protein, partial cds; Start codon is not I.GEEAPCRHPREALDGPVFSR.N 2 3.005 0.171 O (93%) identified.. Homo sapiens mRNA for KIAA1301 IPI:IPI00017163.1 GP:AB037722_1 protein, partial cds; Start codon is not G.LYHIDENSPANFWDSKNR.G 2 2.898 0.114 O (95%) identified.. Homo sapiens mRNA for KIAA1306 GP:AB037727_1 protein, partial cds; Start codon is not F.ILTESDTVKRR.P 2 2.330 0.120 G, O identified.. S.EAVSQWLTAF.Q 2 2.478 0.111 Homo sapiens mRNA for KIAA1337 IPI:IPI00002283.3 GP:AB037758_1 protein, partial cds; Start codon is not G.AQKPGPQPGAGGQCCWR.H 1 1.813 0.109 A, P (91%) identified.. Supplementary Table 1 19 V.GIGVDDVFVFINTYRQAT.H 2 2.444 0.219 Homo sapiens mRNA for KIAA1341 GP:AB037762_1 protein, partial cds; Start codon is not D.GKTPQLPR.G 1 1.847 0.087 P identified.. Homo sapiens mRNA for KIAA1344 IPI:IPI00165983.1 GP:AB037765_1 protein, partial cds; Start codon is not I.ITDALLEMFPEITVENL.P 3 3.959 0.083 P (95%) identified.. Homo sapiens mRNA for KIAA1355 GP:AB037776_1 protein, partial cds; Start codon is not A.SNAVAR.V 1 2.328 0.096 A identified.. P.PAVLEVQELEPVTLRCVAR.G 2 2.222 0.103 Homo sapiens mRNA for KIAA1372 GP:AB037793_1 protein, partial cds; Start codon is not L.YIEGLDSKEAGGQSSQE.E 2 2.874 0.083 P identified.. Homo sapiens mRNA for KIAA1380 D.LQKRKGEIEEDLKPNGVLSRSAKERSK IPI:IPI00018844.1 GP:AB037801_1 protein, partial cds; Start codon is not 3 3.818 0.222 A, G, P LK.L (97%) identified.. Homo sapiens mRNA for KIAA1381 IPI:IPI00141561.1 GP:AB037802_1 protein, partial cds; Start codon is not R.SSTFNSQEPHNILPLAS.S 2 2.568 0.102 G, O, P (92%) identified.. S.SSSKELLVSALQEL.E 2 2.766 0.125 Homo sapiens mRNA for KIAA1393 IPI:IPI00174029.1 GP:AB037814_1 protein, partial cds; Start codon is not I.PVAKKNCTVFANDLNPESHK.W 2 2.574 0.126 G (99%) identified.. Homo sapiens mRNA for KIAA1395 IPI:IPI00044299.4 GP:AB037816_1 protein, partial cds; Start codon is not L.VIKLEK.V 1 2.291 0.083 P (92%) identified.. Homo sapiens mRNA for KIAA1403 protein, partial cds; Start codon is not identified. fg02666 cDNA clone for GP:AB037824_1 G.LQPLVEPCLRQTLKLL.S 2 3.402 0.102 G, P KIAA1403 has a 118-bp insertion after the position 867 of the sequence of KIAA1403.. S.GLQPLVEPCLRQTLKLL.S 2 2.780 0.102 T.PRNQGCQLPGSSHSFQGPNLV.T 2 2.451 0.100 Homo sapiens mRNA for KIAA1404 protein, partial cds; Start codon is not identified. fg02672 cDNA clone for KIAA1404 has 307-bp and 150-bp IPI:IPI00220462.1 GP:AB037825_1 F.NLEVSLFERLVKVNIP.F 1 2.236 0.103 A, G deletions at the positions between (95%) 1637 and 1945, and between 2236 and 2387 of the sequence of KIAA1404, respect K.RLSFTSQELSDLRSEI.Q 2 3.422 0.102 L.GYKFLESLLQKDPSEVVI.T 2 2.487 0.142 Homo sapiens mRNA for KIAA1409 protein, partial cds; Start codon is not identified. fh04461 cDNA clone for IPI:IPI00002128.1 GP:AB037830_1 L.FQSTIKDGTF.L 1 2.216 0.172 O KIAA1409 has a 31-bp insertion after (95%) the position 3913 of the sequence of KIAA1409.. S.GQSSAGLAALRK.W 1 1.934 0.080 Homo sapiens mRNA for KIAA1420 protein, partial cds; Start codon is not identified. hk03917 cDNA clone for GP:AB037841_1 KIAA1420 has two 1-bp insertions R.DPDLKDRALLNGG.T 1 2.235 0.114 O after the positions 1400 and 2614 of the sequence of KIAA1420, respectively.. Homo sapiens mRNA for KIAA1427 GP:AB037848_1 protein, partial cds; Start codon is not K.NLHSNQSKELL.G 1 2.439 0.115 G, P identified.. Homo sapiens mRNA for KIAA1429 GP:AB037850_1 protein, partial cds; Start codon is not D.ENNAKLQELGKWLEPLK.N 2 2.226 0.107 P identified.. L.EEIPSLIIKGLSYLQLKNT.K 2 2.669 0.122 Homo sapiens mRNA for KIAA1430 GP:AB037851_1 protein, partial cds; Start codon is not D.CLDAGSDSHLSDSSPSSKSSKKHV.S 2 2.867 0.083 G, O, P identified.. Homo sapiens mRNA for KIAA1432 IPI:IPI00164719.1 GP:AB037853_1 protein, partial cds; Start codon is not L.FEECLMAQDLDTAASYL.I 1 2.926 0.103 G (93%) identified.. Homo sapiens mRNA for KIAA1442 GP:AB037863_1 protein, partial cds; Start codon is not N.RNETPSDPVIIDR.F 2 2.250 0.223 O, P identified.. Supplementary Table 1 20 V.VFGNVLVWSELITPHAIR.V 2 2.591 0.166 Homo sapiens MUC3B gene for GP:AB038781_1 L.ETSGPACRCYSTDTHWFSGP.R 2 2.556 0.200 O, P intestinal mucin, partial cds. M.SSSPSSASITPVF.A 2 2.422 0.165 Homo sapiens ALS2CR3 mRNA for amyotrophic lateral sclerosis 2, GP:AB038951_1 R.LKVDTLFLYENQDWTQS.P 2 2.985 0.095 A candidate 3, complete cds; candidate 3. Homo sapiens mRNA for H-Haspin, IPI:IPI00154918.1 GP:AB039834_1 A.CLVAASAVPSDLHLPEVS.L 1 2.249 0.098 G complete cds. (92%) Homo sapiens mRNA for KIAA1450 L.QLYKLHLPADFCIMHLEDRLQEMYLKS. IPI:IPI00185592.1 GP:AB040883_1 protein, partial cds; Start codon is not 3 3.800 0.114 G, P K (92%) identified.. R.ILYVLTYFLR.C 1 1.906 0.148 Homo sapiens mRNA for KIAA1453 IPI:IPI00217672.1 GP:AB040886_1 protein, partial cds; Start codon is not C.LTYTPPLANYLLSK.E 2 2.647 0.096 P (93%) identified.. I.QCLTYTPPLANYLLSK.E 2 2.569 0.123 Homo sapiens mRNA for KIAA1458 GP:AB040891_1 protein, partial cds; Start codon is not N.RFSPSPRNSPRPSPK.Q 2 2.900 0.149 O identified.. Homo sapiens mRNA for KIAA1461 GP:AB040894_1 protein, partial cds; Start codon is not K.NLDHGKNVNEGD.G 1 2.125 0.088 O, P identified.. K.NLDHGKNVNEGDGFEYFKSA.S 2 3.606 0.135 Homo sapiens mRNA for KIAA1474 GP:AB040907_1 protein, partial cds; Start codon is not K.DKPGEEEEK.C 1 2.243 0.119 P identified.. Homo sapiens mRNA for KIAA1481 IPI:IPI00155504.1 GP:AB040914_1 protein, partial cds; Start codon is not R.ERAQSAYLQPGPA.A 2 2.572 0.099 P (99%) identified.. Homo sapiens mRNA for KIAA1484 GP:AB040917_1 protein, partial cds; Start codon is not G.ALEPPTSAPPTLALVPGGAAARPR.P 2 2.234 0.201 A identified.. V.GQMVNLNTLTLDHNLIDHIAEG.T 2 2.486 0.112 Homo sapiens mRNA for KIAA1488 IPI:IPI00027415.1 GP:AB040921_1 protein, partial cds; Start codon is not L.FFGGDISIQK.D 2 2.328 0.108 A, O (96%) identified.. R.KMVKVYTKTDGLVAVHPKSVN.V 2 3.539 0.205 Homo sapiens mRNA for KIAA1498 GP:AB040931_1 protein, partial cds; Start codon is not L.APVSGSGPGPSPARSSPVNR.P 2 2.306 0.130 A, G identified.. S.SATNKALSPVTSRTPGV.V 1 2.024 0.157 Homo sapiens mRNA for KIAA1507 IPI:IPI00152486.1 GP:AB040940_1 protein, partial cds; Start codon is not L.SRAPAFAF.V 1 2.285 0.132 O (92%) identified.. Homo sapiens mRNA for KIAA1511 protein, partial cds; Start codon is not identified. fg04486 cDNA clone for GP:AB040944_1 R.GGPGAGAAGGAAGASPAEEGP.Q 1 1.940 0.157 A, G KIAA1511 has a 749-bp insertion after the position 2901 of the sequence of KIAA1511.. S.SFQYRGGPGAGAAGGAA.G 2 2.945 0.142 Homo sapiens mRNA for KIAA1512 protein, partial cds; Start codon is not identified. fg04660 cDNA clone for GP:AB040945_1 A.KRQELEETHVSI.T 2 2.638 0.165 A, G KIAA1512 has a 223-bp insertion after the position 2196 of the sequence of KIAA1512.. L.EEAKKKLALRLQEAEE.G 2 2.697 0.126 L.NPSAIPDDTF.M 2 2.569 0.174 L.TDQVSLSGKSIQELEKT.K 2 2.981 0.154 Homo sapiens mRNA for KIAA1515 protein, partial cds; Start codon is not identified. fh04655 cDNA clone for KIAA1515 has a 1837-bp insertions IPI:IPI00103951.1 GP:AB040948_1 L.KYNDISVTESSWEEVE.R 1 2.232 0.090 G after the position 271, and a 22-bp (93%) deletion at the position between 952 and 975 of the sequence of KIAA1515, Homo sapiens mRNA for KIAA1517 protein, partial cds; Start codon is not GP:AB040950_1 identified. fh11426 cDNA clone for I.QKDFLLLR.Y 1 2.284 0.089 P KIAA1517 has a 1309-bp insertion after the position 2160 of the Supplementary Table 1 21 sequence of KIAA1517.. Homo sapiens mRNA for KIAA1526 protein, partial cds; Start codon is not identified. fj04743 cDNA clone for IPI:IPI00164114.1 GP:AB040959_1 S.DSGQTLSEDSGVDAGEAEASA.P 2 2.749 0.168 O KIAA1526 has a 1196-bp insertion (93%) after the position 1335 of the sequence of KIAA1526.. Homo sapiens mRNA for KIAA1542 IPI:IPI00178613.1 GP:AB040975_1 protein, partial cds; Start codon is not A.AIQREVSLMHDEDPSQPP.P 2 2.903 0.088 O (93%) identified.. Mus musculus brain cDNA, clone MNCb-4414, similar to NM_005827 GP:AB041549_1 UDP-galactose transporter related F.VFIGTLMYTEVWK.N 2 2.923 0.085 O, P (Homo sapiens); unnamed protein product. Mus musculus brain cDNA, clone MNCb-1192, similar to Homo sapiens GP:AB041566_1 retinoic acid repressible protein A.SARRDKTLLKEKRKR.R 2 3.444 0.092 G (RARG-1) mRNA; unnamed protein product. Mus musculus brain cDNA, clone MNCb-2643, similar to Human mRNA GP:AB041589_1 R.KGGRQGPSGKRRGGPPGQGEK.R 2 3.005 0.274 A for KIAA0112 gene; unnamed protein product. Homo sapiens gene for PQBP-1, IPI:IPI00024698.1 GP:AB041832_1 PQBP-1a, PQBP-1b/c, PQBP1-1d, S.SNAAVSR.K 1 2.323 0.182 A, O (97%) complete cds. Homo sapiens JP3 mRNA for G.KAHGHGVCTGPKGQGEYTGSWSHGF GP:AB042636_1 3 4.023 0.215 O junctophilin type3, complete cds. EVLGVYTWPSGNTY.Q Homo sapiens B29 mRNA, complete GP:AB042647_1 K.REPLKNVF.F 1 1.847 0.106 A, O cds. Homo sapiens mRNA for zinc finger GP:AB043584_1 A.GAGGAVNGRGGGFAPGTEPF.P 2 2.835 0.083 A, G protein hRit1 alpha, complete cds. Y.CGKVFKNCSNLTVHRRSHTGERPYK.C 2 2.450 0.160 Homo sapiens hUGTrel7 mRNA for GP:AB044343_1 Y.NALFMILPTLAIAYFTGDAQKAV.E 2 3.476 0.087 O, P UDP-glucuronic acid, complete cds. Homo sapiens mRNA for nucleolar GP:AB044971_1 phosphoprotein Nopp34, complete L.DETQIFSYFSQFGTVTR.F 2 2.743 0.164 A cds. Homo sapiens mRNA for KIAA1545 GP:AB046765_1 protein, partial cds; Start codon is not E.KSEAKAGPVPK.V 1 2.242 0.101 A, O identified.. F.GPSAHPGSFLPTGP.L 1 2.037 0.122 I.KEMQLDPHKLEVG.A 1 2.206 0.087 Homo sapiens mRNA for KIAA1553 IPI:IPI00014710.2 GP:AB046773_1 protein, partial cds; Start codon is not P.NIYFLIQK.M 1 1.846 0.085 P (93%) identified.. Homo sapiens mRNA for KIAA1554 I.GGIDHKPRDGFHLVKDKADRTQTGHVL IPI:IPI00183222.1 GP:AB046774_1 protein, partial cds; Start codon is not 3 4.175 0.124 O GNPQ.R (99%) identified.. Homo sapiens mRNA for KIAA1561 IPI:IPI00173359.1 GP:AB046781_1 protein, partial cds; Start codon is not L.KVKYEGASAEVG.K 1 2.167 0.099 A, P (92%) identified.. Q.TLQKEIEKVYLDNKLLK.E 2 2.572 0.092 Homo sapiens mRNA for KIAA1568 GP:AB046788_1 protein, partial cds; Start codon is not G.DVLVR.L 1 1.828 0.163 A, P identified.. L.QGPANQTLAVDGTALLKCKATGDPLPV 2 2.618 0.233 I.S Homo sapiens mRNA for KIAA1579 IPI:IPI00164189.1 GP:AB046799_1 protein, partial cds; Start codon is not V.CLSSPASK.T 1 1.801 0.111 P (98%) identified.. Homo sapiens mRNA for KIAA1584 IPI:IPI00025141.1 GP:AB046804_1 protein, partial cds; Start codon is not K.MDHKTQHHRTFIKPK.Q 1 1.860 0.082 G (95%) identified.. K.VSVCIPTSEHLSELKKEAP.A 2 2.709 0.198 V.SGLDNMATHLSQHKTHTCQVVMQKVS 3 3.787 0.137 VCIPTSEHLSELKKE.A Homo sapiens mRNA for KIAA1588 IPI:IPI00215655.1 GP:AB046808_1 protein, partial cds; Start codon is not E.CHQCQKAFTTSASLTRHRRI.H 2 2.875 0.146 A (98%) identified.. Homo sapiens mRNA for KIAA1590 IPI:IPI00220596.1 GP:AB046810_1 protein, partial cds; Start codon is not K.EGGNINKSLVTLGNVISALADL.S 2 2.676 0.133 P (98%) identified.. Homo sapiens mRNA for KIAA1594 GP:AB046814_1 F.TYNDLEVSKIQEAAVQSDR.D 2 2.662 0.107 G protein, partial cds; Start codon is not Supplementary Table 1 22 identified.. Homo sapiens mRNA for KIAA1596 IPI:IPI00176581.1 GP:AB046816_1 protein, partial cds; Start codon is not G.LSDLEYEIAKGTALENL.L 1 2.100 0.126 G, O (95%) identified.. P.LSAAKNEELLSPGYSQF.S 2 2.425 0.143 Homo sapiens mRNA for KIAA1598 GP:AB046818_1 protein, partial cds; Start codon is not K.RSHPSGSGAKKEK.A 2 2.722 0.082 P identified.. Homo sapiens mRNA for KIAA1618 IPI:IPI00217287.1 GP:AB046838_1 protein, partial cds; Start codon is not E.KILANVTEDAKRLI.A 2 2.499 0.155 A, G, O (97%) identified.. F.TKNMLTSSGASFTYVKEIEVWRRLVEI. 3 3.926 0.108 Q V.DAVAEPANAVKGAGK.E 2 2.431 0.113 Homo sapiens mRNA for KIAA1623 GP:AB046843_1 protein, partial cds; Start codon is not R.EPPAILFRRAGGE.G 1 1.933 0.108 G, P identified.. V.FGSVLYTFTEADQT.S 2 2.418 0.110 Homo sapiens mRNA for KIAA1630 protein, partial cds; Start codon is not identified. fh15267 cDNA clone for IPI:IPI00063408.1 GP:AB046850_1 R.KPLIVASPKML.L 1 2.123 0.124 G KIAA1630 has a 199-bp deletion at (99%) the position between 1194 and 1394 of the sequence of KIAA1630.. Homo sapiens mRNA for KIAA1633 protein, partial cds; Start codon is not identified. fh19672 cDNA clone for IPI:IPI00220284.1 GP:AB046853_1 I.KKITQELSDLQQ.E 1 2.858 0.090 A, G, O KIAA1633 has 1-bp (C) replacing 2-bp (98%) (GG) at the position between 829 and 832 of the sequence of KIAA1633.. 2 2.806 0.085 R.YDSLVQSQARE.L 1 2.869 0.210 Homo sapiens mRNA for KIAA1643 protein, partial cds; Start codon is not identified. hh10131 cDNA clone for GP:AB046863_1 T.LERNLCISQDVEFPIRADVQGPA.A 2 2.856 0.084 P KIAA1643 has a 1393-bp insertion after the position 2642 of the sequence of KIAA1643.. Homo sapiens PC-LKC mRNA for IPI:IPI00164796.1 GP:AB047004_1 E.EVGANR.Q 1 1.919 0.080 A, O, P protocadherin LKC, complete cds. (91%) I.SKDGATIPFQGVFSIFTSS.E 2 2.874 0.125 S.LDDNSVDVDK.N 1 2.020 0.085 Homo sapiens mRNA for MAST205, IPI:IPI00059808.1 GP:AB047005_1 E.QDVVTGVSPLL.F 1 2.414 0.081 O complete cds. (96%) Homo sapiens mRNA for Rev1S, K.HEGPPAEKPLEELSASTSGVPGLSSLQ IPI:IPI00008816.1 GP:AB047646_1 3 3.626 0.093 O complete cds. SDPAGCV.R (93%) Homo sapiens MARKL1 mRNA for IPI:IPI00166436.1 GP:AB049127_1 MAP/microtubule affinity-regulating G.YEGEELK.P 1 2.579 0.125 A, O, P (91%) kinase like 1, complete cds. Homo sapiens lhpp mRNA for phospholysine phosphohistidine IPI:IPI00186454.1 GP:AB049629_1 G.VEAHQAVMIGDDI.V 2 2.742 0.117 A inorganic pyrophosphate (95%) phosphatase, complete cds. Homo sapiens MRPS11 mRNA for GP:AB049944_1 mitochondrial ribosomal protein S11, M.QAVRNAGSRFLR.S 2 2.826 0.107 O, P complete cds. Homo sapiens mRNA for VSGP/F- IPI:IPI00171473.1 GP:AB051390_1 A.LLALALPLAAALAFS.D 2 2.584 0.155 G spondin, complete cds. (93%) D.KVPKSEGYCSRILRAQGTRREGYTEFS 3 3.873 0.257 LRV.E Homo sapiens mRNA for KIAA1646 IPI:IPI00152433.1 GP:AB051433_1 protein, partial cds; Start codon is not G.RTQRSAGVDQNHPRAVLVPSSLR.I 2 2.205 0.201 O, P (97%) identified.. K.KALYGLEAAEDVEEWQVVCGKFLAINA 3 3.513 0.187 TNMSCACRRSP.R Homo sapiens mRNA for KIAA1669 IPI:IPI00045491.1 GP:AB051456_1 protein, partial cds; Start codon is not D.ASISLGESVSDMAPAR.P 2 2.429 0.180 A, G, O, P (93%) identified.. L.ISREECLCHSMIQETL.Q 1 2.208 0.084 R.ACVLSTPPTLSLLTIGFL.F 1 1.914 0.129 S.DVAPTQPR.W 1 1.826 0.085 Homo sapiens mRNA for KIAA1677 IPI:IPI00151841.1 GP:AB051464_1 protein, partial cds; Start codon is not E.ILQAAMYVQLI.E 1 2.074 0.107 G, O (92%) identified..
Supplementary Table 1 23 Y.FQNVHQQPLLDMK.S 2 2.978 0.101 Homo sapiens mRNA for KIAA1678 IPI:IPI00028494.1 GP:AB051465_1 protein, partial cds; Start codon is not I.QIETDQREACAGEPE.P 1 2.251 0.100 G (92%) identified.. T.NHSPLDSKKETSSCQD.P 2 3.023 0.144 Homo sapiens mRNA for KIAA1680 GP:AB051467_1 protein, partial cds; Start codon is not H.LQKAFASRVDKSTQTELLC.Y 2 3.427 0.209 A, G, P identified.. L.GSCELDEDDLMLDLEF.L 2 3.184 0.128 P.KSFSSHYKFSK.P 1 2.110 0.081 Homo sapiens mRNA for KIAA1681 GP:AB051468_1 protein, partial cds; Start codon is not R.KSITRHGSLSSRMSRAE.P 1 2.061 0.087 G identified.. Homo sapiens mRNA for KIAA1685 A.AAAAAAAAAAAASVGGTIPGPGPGGG GP:AB051472_1 protein, partial cds; Start codon is not 2 2.518 0.106 G QGPGEGGEG.Q identified.. A.AAAAAAAAAAAASVGGTIPGPGPGGG 3 3.521 0.100 QGPGEGGEGQTARGGSPGSDR.V Homo sapiens mRNA for KIAA1688 L.SLEYSPAGKEYVRQLVYVEQAGSSPK. IPI:IPI00216342.1 GP:AB051475_1 protein, partial cds; Start codon is not 2 2.674 0.080 A L (92%) identified.. Homo sapiens mRNA for KIAA1691 GP:AB051478_1 protein, partial cds; Start codon is not T.GFCYDGVEGLIYLALFSFV.T 2 2.748 0.205 O identified.. Homo sapiens mRNA for KIAA1692 IPI:IPI00183766.1 GP:AB051479_1 protein, partial cds; Start codon is not E.YQDKLYLHLK.K 1 2.019 0.098 G, O (96%) identified.. P.QQKDLDQVQLHLEEVRFFDV.F 2 2.515 0.165 Homo sapiens mRNA for KIAA1697 IPI:IPI00187146.1 GP:AB051484_1 protein, partial cds; Start codon is not I.KLTDSNFLRILENSIR.L 2 2.933 0.102 A, G, O, P (99%) identified.. L.RTSFVDLWLKR.G 1 2.168 0.110 Homo sapiens mRNA for KIAA1711 IPI:IPI00178106.1 GP:AB051498_1 protein, partial cds; Start codon is not R.NNESESTLDL.E 1 2.217 0.095 O, P (97%) identified.. Homo sapiens mRNA for KIAA1712 IPI:IPI00028386.1 GP:AB051499_1 protein, partial cds; Start codon is not K.GKVMVDENTWTNLLSRVTLLETE.M 2 2.729 0.117 A (97%) identified.. Homo sapiens mRNA for KIAA1714 P.PFEARFLRFLPLAWNPRGRIGMRIEVY. IPI:IPI00179776.1 GP:AB051501_1 protein, partial cds; Start codon is not 3 3.843 0.106 A G (99%) identified.. Homo sapiens mRNA for KIAA1715 GP:AB051502_1 protein, partial cds; Start codon is not C.FFLNPARKTR.P 2 2.641 0.113 G, O identified.. L.EEFREKNQRLQK.L 1 2.561 0.095 Homo sapiens mRNA for KIAA1718 IPI:IPI00163773.1 GP:AB051505_1 protein, partial cds; Start codon is not R.VQSRNYVDSSGS.S 1 1.897 0.132 G (96%) identified.. Homo sapiens mRNA for KIAA1728 IPI:IPI00183939.1 GP:AB051515_1 protein, partial cds; Start codon is not S.TSSLTSSSSFSDGFK.V 1 1.953 0.162 G (96%) identified.. Homo sapiens mRNA for KIAA1735 IPI:IPI00028306.1 GP:AB051522_1 protein, partial cds; Start codon is not I.QSRLDQSMEENQ.D 1 2.844 0.085 A (93%) identified.. Homo sapiens mRNA for KIAA1736 IPI:IPI00180828.1 GP:AB051523_1 protein, partial cds; Start codon is not L.AGAVIGDGQSAVASNIANTTYRLQW.W 2 2.921 0.098 G (99%) identified.. Homo sapiens mRNA for KIAA1746 IPI:IPI00034201.1 GP:AB051533_1 protein, partial cds; Start codon is not K.VYVVGNEPLTVLMDSLL.P 1 1.972 0.210 O (96%) identified.. Homo sapiens mRNA for KIAA1750 GP:AB051537_1 protein, partial cds; Start codon is not G.KAASLSERL.A 1 2.271 0.123 P identified.. Homo sapiens mRNA for KIAA1751 IPI:IPI00028278.1 GP:AB051538_1 protein, partial cds; Start codon is not E.AVAAEIATEEEAGNMAAVG.R 2 3.240 0.139 O, P (92%) identified.. Q.EIISR.I 1 1.805 1.000 Homo sapiens mRNA for KIAA1757 protein, partial cds; Start codon is not identified. fh19225 cDNA clone for GP:AB051544_1 KIAA1757 has 338-bp and 485-bp H.QYRLQPLQGSGVK.T 2 2.267 0.100 G, O, P insertions after the positions 577 and 3879 of the sequence of KIAA1757, respectively.. K.VGYLDSNTNSCA.D 1 1.810 0.106 Supplementary Table 1 24 Y.SYQLLQCDSPRTESQSL.L 2 2.886 0.095 Homo sapiens mRNA for KIAA1760 protein, partial cds; Start codon is not identified. fh22167 cDNA clone for GP:AB051547_1 A.LHVQAQVNNSNNK.K 2 2.584 0.087 A, O KIAA1760 has a 1-bp deletion at the position 2242 of the sequence of KIAA1760.. L.ADSSRGPPAKDPAQASVGLTADSTGLS 3 3.508 0.120 GKAVQTQQPCSVR.A L.SQAGPSNPPGAPPAP.L 1 2.220 0.112 Homo sapiens mRNA for KIAA1762 protein, partial cds; Start codon is not identified. fh27937 cDNA clone for GP:AB051549_1 C.GACGKLFSNMLILKTHEEHV.H 3 3.979 0.101 A, O KIAA1762 has a 261-bp insertion after the position 3403 of the sequence of KIAA1762.. D.SSASSLAEPESPGAGGTSGGPGGGTG 2 2.531 0.122 V.P Homo sapiens mRNA for KIAA1764 protein, partial cds; Start codon is not identified. fj10485 cDNA clone for GP:AB051551_1 L.NVSYNHIDDLSGLIPLHGIKHKLRYID.L 3 4.022 0.131 O, P KIAA1764 has a 194-bp deletion at the position between 1759 and 1954 of the sequence of KIAA1764.. Homo sapiens mRNA for KIAA1766 protein, partial cds; Start codon is not identified. fj16085 cDNA clone for IPI:IPI00159534.1 GP:AB051553_1 I.VEERVNRPGWNEDDDVSVSD.E 2 2.500 0.134 A KIAA1766 has a 37-bp deletion at the (96%) position between 280 and 318 of the sequence of KIAA1766.. V.SERGPPYRSCDLFDELVAFEVE.R 2 2.434 0.207 Homo sapiens mRNA for KIAA1770 protein, partial cds; Start codon is not identified. pj01645 cDNA clone for IPI:IPI00024703.1 GP:AB051557_1 E.NQPADPKEKSPQMGANK.K 1 2.299 0.194 A KIAA1770 has a 128-bp deletion at (91%) the position between 1513 and 1642 of the sequence of KIAA1770.. Homo sapiens mRNA for KIAA1771 protein, partial cds; Start codon is not identified. pj02581 cDNA clone for IPI:IPI00183572.1 GP:AB051558_1 KIAA1771 has a 1-bp deletion at the A.KKLSTIHGK.L 1 1.826 0.087 P (93%) position 498 and a 110-bp insertion after the position 3119 of the sequence of KIAA1771, respectively.. Homo sapiens mRNA for proacrosin GP:AB051833_1 binding protein sp32 precursor, L.SSNPSSFAPRVR.E 2 2.572 0.113 P complete cds. N.SYWRNQNPGSFLQLPHTEAL.L 2 2.470 0.186 Homo sapiens SRCL mRNA for GP:AB052103_1 scavenger receptor with C-type lectin L.QNEPTPAPEDNSKSK.P 1 2.369 0.123 P type II, complete cds. Homo sapiens hgsg3 mRNA, GP:AB053259_1 R.ILSDLNLVMYPK.L 1 2.365 0.156 A complete cds. Homo sapiens PINK1 mRNA for IPI:IPI00168326.1 GP:AB053323_1 PTEN induced putative kinase 1, L.RFFRQSVAGLAARLQR.Q 2 2.863 0.093 O (98%) complete cds. Homo sapiens mRNA for KIAA1774 IPI:IPI00216562.1 GP:AB053445_1 protein, partial cds; Start codon is not R.KLKAIVAGSAGNRGFIDIMD.M 2 2.501 0.222 G (95%) identified. Homo sapiens mRNA for KIAA1773 GP:AB053446_1 protein (dachsous homologue), L.RPGSLLGSVAAPEPAGVGALTYTL.V 2 2.940 0.154 A, O complete cds. V.TLSLSGGDPRGLFSLDAVSGLLQT.L 2 2.923 0.165 Homo sapiens chac mRNA for IPI:IPI00045400.1 GP:AB054005_1 I.NYLHNILPQSEE.K 2 2.935 0.117 A, G chorein, complete cds. (93%) Q.ASFTDVRDPSLKLAEFK.L 1 1.947 0.191 Homo sapiens mRNA for NPAS3 E.HFPSPQGGGGGGGGGGGLHVAIPDS IPI:IPI00000886.1 GP:AB054575_1 2 2.564 0.168 A, G (MOP6), complete cds. V.L (98%) F.PSPQGGGGGGGGGGGLHVAIPDSV.L 2 2.537 0.114 P.SPQGGGGGGGGGGGLHVAIPDSVLTP 3 3.866 0.234 PGADGAAARKTQFGASA.T Homo sapiens c-lbc mRNA for IPI:IPI00029653.1 GP:AB055890_1 guanine nucleotide exchange factor K.ALQLSNSPG.A 1 1.803 0.116 P (99%) Lbc, complete cds. Homo sapiens N-Tes mRNA for IPI:IPI00027218.2 GP:AB056866_1 A.AWCSQSLAAAAAVAAAGGRS.D 2 2.960 0.169 O testican 3 splicing variant, complete (94%) Supplementary Table 1 25 cds; testican 3 N terminal. Homo sapiens PIG-S mRNA for P.LKSSLGYEITFSLLNPDPKSHDVYWDIE IPI:IPI00045502.2 GP:AB057723_1 phosphatidyl inositol glycan class S, 3 3.797 0.128 G, P GAVRR.Y (92%) complete cds. V.PILLSLVKIFLETRKS.W 2 2.652 0.124 Homo sapiens arpp mRNA for IPI:IPI00006467.1 GP:AB058599_1 V.DEETFLK.A 1 1.817 0.168 A ankyrin-repeat protein, complete cds. (97%) Homo sapiens mRNA for KIAA1794 IPI:IPI00064217.1 GP:AB058697_1 protein, partial cds; Start codon is not L.DKSADFSQSTSIGIKNNISAF.L 2 2.616 0.208 O (91%) identified.. Homo sapiens mRNA for KIAA1797 IPI:IPI00015781.1 GP:AB058700_1 protein, partial cds; Start codon is not Q.DRVYPELQRFMAV.S 1 2.123 0.180 A (95%) identified.. Homo sapiens mRNA for KIAA1798 IPI:IPI00064214.1 GP:AB058701_1 protein, partial cds; Start codon is not K.AWCWASYLEEEK.A 2 4.301 0.126 O, P (96%) identified.. Homo sapiens mRNA for KIAA1803 D.ASGALVGRVDGEHCLLDGMLEDETRP IPI:IPI00169420.1 GP:AB058706_1 protein, partial cds; Start codon is not 3 3.590 0.176 A, O GGYHCSQCDR.V (96%) identified.. D.VEETSRIFKQGYGAYRCKLCPYTHGTL 3 3.835 0.118 EK.L Homo sapiens mRNA for KIAA1807 IPI:IPI00101929.1 GP:AB058710_1 protein, partial cds; Start codon is not K.RDPLQNSPGSEGK.T 1 2.290 0.131 G (96%) identified.. Y.NQTAVKVPTTPASPVK.N 2 2.291 0.118 Homo sapiens mRNA for KIAA1815 IPI:IPI00147867.1 GP:AB058718_1 protein, partial cds; Start codon is not M.NASAQYLGEVFFDI.S 1 2.084 0.094 G (97%) identified.. Homo sapiens mRNA for KIAA1817 GP:AB058720_1 protein, partial cds; Start codon is not V.SCLTTCASGGECLGAPNYR.K 2 2.520 0.101 G identified.. Homo sapiens mRNA for KIAA1819 IPI:IPI00216776.1 GP:AB058722_1 protein, partial cds; Start codon is not D.NMGPALNSDADFIDSL.L 2 2.952 0.102 A, G (92%) identified.. T.LNGQTMGPLR.G 2 2.404 0.100 Homo sapiens mRNA for KIAA1820 GP:AB058723_1 protein, partial cds; Start codon is not D.NSHLPATFK.V 1 1.858 0.088 O identified.. G.AGTPSGTAAAVAADKYHRGSKAL.P 2 2.603 0.106 Homo sapiens mRNA for KIAA1832 protein, partial cds; Start codon is not identified. fg02852 cDNA clone for IPI:IPI00103363.1 GP:AB058735_1 KIAA1832 has 426-bp and 2680-bp L.NACSGDAK.S 1 2.066 0.084 P (92%) insertions after the positions 1128 and 1725 of the sequence of KIAA1832, respectively.. Homo sapiens mRNA for KIAA1833 protein, partial cds; Start codon is not identified. fg05835 cDNA clone for L.KDGLVHPDPAILFHTCHSVGQIIAKRLP IPI:IPI00167967.1 GP:AB058736_1 2 2.446 0.153 G, O KIAA1833 has a 119-bp insertion after PDQ.L (94%) the position 3222 of the sequence of KIAA1833.. P.FLPSVLSSLLPVLGVAKQDTVRVA.F 2 2.439 0.107 Homo sapiens mRNA for KIAA1836 protein, partial cds; Start codon is not identified. fh12206 cDNA clone for GP:AB058739_1 L.EALEKGQPVDLSAMPPAPE.D 1 2.435 0.138 P KIAA1836 has a 399-bp insertion after the position 1352 of the sequence of KIAA1836.. Homo sapiens mRNA for KIAA1840 protein, partial cds; Start codon is not identified. fj19761 cDNA clone for IPI:IPI00178559.1 GP:AB058743_1 L.KSSIFEEISKK.Y 1 2.366 0.097 A, O KIAA1840 has a 229-bp deletion at (96%) the position between 2568 and 2798 of the sequence of KIAA1840.. Homo sapiens mRNA for KIAA1843 protein, partial cds; Start codon is not identified. pj01248 cDNA clone for IPI:IPI00064174.2 GP:AB058746_1 K.MAACQLLLEITTFLR.E 2 2.259 0.253 P KIAA1843 has a 1-bp deletion at the (93%) position 754 of the sequence of KIAA1843.. L.EKLTISNRQDELMYMLRKLLLNIGDFPA 3 3.820 0.116 QTS.H Homo sapiens mRNA for KIAA1862 GP:AB058765_1 protein, partial cds; Start codon is not R.RAEPRNWTADKEGSAPKPS.P 2 2.805 0.083 P identified.. Supplementary Table 1 26 Homo sapiens mRNA for KIAA1871 GP:AB058774_1 protein, partial cds; Start codon is not N.FQGTSDLIRHQV.T 2 2.719 0.109 A identified.. Homo sapiens mRNA for KIAA1873 IPI:IPI00064126.1 GP:AB058776_1 protein, partial cds; Start codon is not K.LRSTLPEEQKKQEISK.S 1 1.921 0.101 P (96%) identified.. Homo sapiens mRNA for KIAA1874 IPI:IPI00010163.1 GP:AB058777_1 protein, partial cds; Start codon is not P.VSKPESHNLENGKE.P 2 3.303 0.126 A, G, P (99%) identified.. Homo sapiens mRNA for KIAA1878 GP:AB058781_1 protein, partial cds; Start codon is not E.AGFSASIMAWPCITRACCIARF.W 2 2.620 0.185 A identified.. Homo sapiens NLRR-3 mRNA for IPI:IPI00217829.1 GP:AB060967_1 neuronal leucine-rich repeat protein-3, M.EICLPLIAPESFPSNLNVEAGSYV.S 2 3.095 0.175 G (93%) complete cds. Homo sapiens smg-1 mRNA for phosphatidylinositol 3-kinase-related IPI:IPI00219564.1 GP:AB061371_1 C.CLGLLCASLSYEAEKIFKW.I 2 2.959 0.131 A, P protein kinase, complete cds; hSMG- (98%) 1. V.FFSEAVLTAANECVGVLLGS.L 2 2.623 0.130 Homo sapiens mRNA for KIAA1879 IPI:IPI00060460.1 GP:AB067466_1 protein, partial cds; Start codon is not A.LRQLQTLKGGLGVQPGTWAPAHA.S 2 2.631 0.086 O (99%) identified.. P.HSDGEAGLPVVQEVWGLPRTLTF.S 2 2.406 0.122 Homo sapiens mRNA for KIAA1881 GP:AB067468_1 protein, partial cds; Start codon is not A.VSTGLTGAVNVARGSIQTGVDTSK.T 2 3.117 0.162 P identified.. T.VCSGVTGAMNVAKGTIQTGV.D 2 2.571 0.104 Homo sapiens mRNA for KIAA1883 GP:AB067470_1 protein, partial cds; Start codon is not A.VVSSRNGGETAPGPLGP.A 2 3.052 0.213 P identified.. Homo sapiens mRNA for KIAA1884 IPI:IPI00154298.1 GP:AB067471_1 protein, partial cds; Start codon is not A.ILVPFIALIIAGFVLYLYKHR.R 3 4.464 0.083 P (98%) identified.. Homo sapiens mRNA for KIAA1892 IPI:IPI00102550.1 GP:AB067479_1 protein, partial cds; Start codon is not R.EVRLQNETSYSRV.L 2 2.914 0.116 O (97%) identified.. Homo sapiens mRNA for KIAA1893 IPI:IPI00168485.1 GP:AB067480_1 protein, partial cds; Start codon is not A.AAECAPAAVLLAGGTHG.R 2 2.538 0.176 A, P (94%) identified.. G.EPVSLGKADSAPSRKTESPSLGK.V 2 3.011 0.280 Homo sapiens mRNA for KIAA1902 IPI:IPI00044748.1 GP:AB067489_1 protein, partial cds; Start codon is not K.KIHELEKQ.G 2 2.998 0.101 O, P (91%) identified.. S.KIVELEK.Q 1 2.007 0.111 2 2.281 1.000 V.TPPMPPPPPPPPPPPPPPPPPPPPP.P 2 2.685 0.113 Homo sapiens mRNA for KIAA1903 IPI:IPI00104907.2 GP:AB067490_1 protein, partial cds; Start codon is not L.RTISGNVYILKGMIDQISM.K 2 3.407 0.091 G, P (97%) identified.. Homo sapiens mRNA for KIAA1910 IPI:IPI00102543.1 GP:AB067497_1 protein, partial cds; Start codon is not A.GLQNLEYLNVEYNAIQL.I 2 2.854 0.112 A, O (93%) identified.. D.LNKLEVLILNDNLI.S 1 2.160 0.086 Homo sapiens mRNA for KIAA1921 IPI:IPI00182463.1 GP:AB067508_1 protein, partial cds; Start codon is not P.RSVQDSGQGGREKLELVL.S 2 3.443 0.095 O, P (99%) identified.. Homo sapiens mRNA for KIAA1925 protein, partial cds; Start codon is not identified. fj02353 cDNA clone for IPI:IPI00177394.1 GP:AB067512_1 K.SNSLNSRLF.S 1 1.802 0.132 A, G KIAA1925 has a 1-bp insertion after (95%) the position 1553 of the sequence of KIAA1925.. V.GVCSDGAASMTGKHSEVVTQ.I 1 2.175 0.103 Homo sapiens mRNA for KIAA1928 protein, partial cds; Start codon is not identified. fg05950 cDNA clone for IPI:IPI00186183.1 GP:AB067515_1 KIAA1928 has a 32-bp deletion at the R.SDISGAGGTTT.E 1 1.828 0.253 O (91%) position between 4330 and 4363 and a 107-bp insertion after the position 543 of the sequence of KIAA1928, Homo sapiens mRNA for WNT11, IPI:IPI00014069.2 GP:AB070218_1 L.ERGTRESAFVYALSAAAI.S 1 2.298 0.105 G, P complete cds. (91%) V.PKDLDIRPVKDSELVYLQS.S 2 2.984 0.141 GP:AB074448_1 Macaca fascicularis testis cDNA L.DFCLNIAK.L 1 1.832 0.112 O Supplementary Table 1 27 clone:QtsA-20302, full insert sequence; highly similar to human TEX11 protein. Homo sapiens Chromosome 16 BAC clone CIT987-SKA-670B5 ~complete GP:AC002303_1 L.EDDEDEEDDL.D 2 3.311 0.105 P genomic sequence, complete sequence. Human BAC clone CTA-367O17 from 7p15-p21, complete sequence; IPI:IPI00155755.1 GP:AC002486_1 multidrug resistance protein (P- P.VLFGTTISNNIKYGR.D 3 3.530 0.117 P (94%) glycoprotein); 60-70% similarity to P06795 (PID:g126927). Homo sapiens Chromosome 16 BAC GP:AC003034_1 clone CIT987SK-A-923A4, complete T.AASCYDVQIIDDKGNV.L 2 2.935 0.116 P sequence. Homo sapiens Chromosome 16 BAC IPI:IPI00016455.1 GP:AC004020_2 clone CIT987SK-A-319E8, complete P.TEEEEQALELLSEMEENEPYPA.E 3 4.375 0.123 O, P (92%) sequence. Homo sapiens BAC clone GS1- 155M11 from 7q21-q22, complete IPI:IPI00014959.1 GP:AC004022_3 K.ILIGTVFHK.T 2 2.702 0.226 O sequence; match to Q15166 (99%) (PID:g2499436); H_GS155M11.2. Mus musculus DNA from BAC 10818 containing the Ercc-4 gene, complete sequence; XPF DNA repair endonuclease subunit; Mouse Ercc4 Y.TQGGIIFATSRILVVDFLTGRIPSDLITGI GP:AC004155_1 3 4.148 0.321 P 85% identical to human Ercc4 protein, LVY.R and 39% identical to Drosophila MEI-9 (U27181); Non-consensus splice junction at 100 Homo sapiens Chromosome 16 BAC IPI:IPI00018232.4 GP:AC004382_8 clone CIT987SK-A-152E5, complete D.DSARTFTCDSELEA.E 2 2.605 0.189 O (93%) sequence. Homo sapiens chromosome 19, cosmid R29381, complete sequence; GP:AC004490_1 R.AIDSIHQLWKGTTQPMKLNTRPSTG.L 2 2.560 0.123 O Hypothetical human protein (partial CDS). Homo sapiens chromosome 19, cosmid F23487, complete sequence; Hypothetical human protein; Most similar to (U23510) R12C12.2 gene A.DASSNKFVFGQNMSERVLSPPKLNEV GP:AC004602_2 product [Caenorhabditis elegans] and 3 4.203 0.176 O SSDAN.R sp|P40517|YIG3_YEAST HYPOTHETICAL 36.1 KD PROTEIN IN RNR3-SNP1 INTERGENIC REGION pir Homo sapiens BAC clone CTA-276O3 from 7q22-q31.1, complete sequence; mitochondrial processing peptidase L.SSAARRRLWGFSESLLIRGAAGRSLYF GP:AC004668_3 3 3.771 0.100 G, P beta subunit precursor; similar to GENRL.R Q03346 (PID:g1171010); H_RG276O03.2. T.THYKGPRIVLAAAGGVSHDELLDL.A 2 2.844 0.176 Homo sapiens Chromosome 16 BAC IPI:IPI00019572.1 GP:AC004682_2 clone CIT987SK-A-259H10, complete A.PTLTLYVGK.K 2 2.786 0.192 A, G, O, P (99%) sequence. A.TLINEQWLLTTAK.N 2 3.703 0.306 C.AVAEYGVYVK.V 1 1.825 0.209 2 2.600 0.288 E.GDGVYTLNDKK.Q 1 1.975 0.233 G.YVSGWGQSDNFK.L 2 3.279 0.244 I.APTLTLYVGK.K 2 2.411 0.162 I.LGGHLDAK.G 1 1.800 0.112 2 2.622 0.135 K.AVGDKLPECEAVCGK.P 2 2.931 0.132 K.AVGDKLPECEAVCGKPKNPANPV.Q 2 2.796 0.160 K.AVGDKLPECEAVCGKPKNPANPVQ.R 2 3.407 0.192 3 3.749 0.190 K.AVGDKLPECEAVCGKPKNPANPVQR.I 2 2.819 0.122 K.DIAPTLTLYVGK.K 1 3.004 0.335 2 3.626 0.339 K.DIAPTLTLYVGKK.Q 1 2.743 0.267 2 3.018 0.309
Supplementary Table 1 28 K.GSFPWQAK.M 2 2.647 0.247 K.KQLVEIEK.V 1 2.900 0.174 2 3.324 0.097 K.LPECEAVCGKPKNPANPVQ.R 2 3.716 0.155 K.NPANPV.Q 1 1.820 0.096 K.NPANPVQ.R 1 2.590 0.139 K.NPANPVQR.I 1 2.110 0.286 2 2.706 0.310 K.PKNPANPVQ.R 1 2.622 0.243 2 3.197 0.249 K.PKNPANPVQR.I 2 2.996 0.291 K.QLVEIEK.V 1 2.168 1.000 2 2.326 1.000 K.SPVGVQPILN.E 1 2.276 0.127 K.SPVGVQPILNEH.T 1 2.936 0.269 2 4.379 0.331 K.SPVGVQPILNEHTF.C 2 4.690 0.430 K.VTSIQHWVQK.T 2 3.580 0.349 K.VVLHPNYHQVDIGLIK.L 2 4.070 0.413 3 4.419 0.414 L.GGHLDAK.G 1 2.240 0.103 L.RTEGDGVYTLNDKK.Q 1 2.809 0.235 2 5.230 0.436 3 3.858 0.275 L.TTGATLINEQWLLTTAK.N 2 4.751 0.391 N.EQWLLTTAK.N 1 2.049 0.336 P.VGVQPILNEHTF.C 2 2.495 0.183 Q.LVEIEK.V 1 1.852 1.000 R.ILGGHLDAK.G 1 2.157 0.091 2 3.073 0.193 R.ILGGHLDAKGSFPWQAK.M 2 4.977 0.412 3 3.990 0.365 R.LRTEGDGVYTLNDKK.Q 1 3.593 0.360 2 5.419 0.439 3 3.710 0.300 R.LRTEGDGVYTLNDKKQWINK.A 2 4.975 0.406 3 5.892 0.325 R.TEGDGVYTLNDK.K 2 3.035 0.252 R.TEGDGVYTLNDKK.Q 1 2.660 0.326 2 4.037 0.307 R.TEGDGVYTLNDKKQWINK.A 2 3.464 0.171 3 4.115 0.315 R.VGYVSGW.G 1 2.020 0.106 R.VGYVSGWG.Q 1 1.899 0.083 R.VGYVSGWGQSDNFK.L 1 2.885 0.321 2 4.436 0.410 T.EGDGVYTLNDKK.Q 2 2.681 0.405 T.LINEQWLLTTAK.N 2 4.174 0.281 T.WYAAGILSFDKSCAVAEYGVYVK.V 2 2.663 0.102 V.VLHPNYHQVDIGLIK.L 2 2.310 0.149 Homo sapiens chromosome 1, BAC CIT-HSP-292g8 (BC262482), complete sequence; Homo sapiens putative 5'-3' exonuclease; similar to IPI:IPI00219173.1 GP:AC004783_1 Drosophila melanogaster Tosca K.EASEPI.H 1 2.109 0.166 A (96%) protein (PID e191388), Schizosaccharomyces pombe ExoI presented in SwissProt Accession Numbe Homo sapiens PAC clone 267D11 from 12, complete sequence; similar to human HsGCN1 U77700 IPI:IPI00027040.3 GP:AC004812_3 G.IKEEVQLTSKQK.E 2 2.878 0.080 G, O, P (PID:g2282576); similar to yeast (95%) translation activator GCN1 (PID:g462168); H_267D11.3. T.PGLKASLLDPVPEVR.T 2 2.466 0.162 Supplementary Table 1 29 Homo sapiens PAC clone RP4-687K1 from 14, complete sequence; U1 small IPI:IPI00024901.1 GP:AC004858_3 ribonucleoprotein 1SNRP homolog; R.KLVPLDYGEDDKNATKGTVNTE.E 2 2.584 0.176 G (96%) match to PID:g4050087; H_DJ0687K01.2. Homo sapiens PAC clone RP4- 728D4, complete sequence; similar to IPI:IPI00177774.1 GP:AC004865_2 K.NEVQLNAYVLQEPPK.G 2 2.632 0.119 O, P KIAA0319; similar to AB002317 (96%) (PID:g2224579); H_DJ0728D04.1. P.KNEVQLNAYVLQEPP.K 2 3.315 0.112 Homo sapiens PAC clone RP4- 751H13 from 7q35-qter, complete IPI:IPI00014661.2 GP:AC004877_2 C.AQGPASCAELSAPR.G 2 2.580 0.085 A sequence; sco-spondin-mucin-like; (91%) similar to P9816. Homo sapiens PAC clone RP1-76B20 from 22, complete sequence; match to human [H55637 (NID:g1108503)], GP:AC004882_4 S.RAEPIR.T 1 1.811 0.117 O mouse [AA119256 (NID:g1676961)], and rat [AI230061 (NID:g3813948)] ESTs; H_DJ076B20.3. Homo sapiens PAC clone RP4-771P4 from 7q11.21-q11.23, complete sequence; similar to general GP:AC004883_4 N.GEYSTGEKNVPAMLGHGK.C 1 2.204 0.099 G transcription factor 2I; similar to AF038969 (PID:g2827207); H_DJ0771P04.3. Homo sapiens PAC clone RP4- 784G16 from 7q11.23-q21.1, complete sequence; C-terminus GP:AC004886_1 matches KIAA0559, N-terminus H.KKGESKQQRKARHRPHGPLL.P 2 2.722 0.122 G, P similar to Bassoon protein; match to PID:g3043642; similar to PID:g3413810; H_DJ0784G16.1. I.RSEEKKPLLEEK.K 2 2.385 0.117 L.KHQIKQEFR.R 2 2.223 0.171 V.SATRSTAPSVGLSSISITI.P 1 2.279 0.269 Homo sapiens BAC clone CTB-15P3 from 7q22-q31.2, complete sequence; IPI:IPI00069287.1 GP:AC005048_1 laminin beta precursor; similar to A.GQCLCKENVEGAKCDQCKPNHYG.L 2 2.507 0.142 G, O (96%) AAB92586 (PID:g2708707); H_RG015P03.1. T.RNDLLTILDTLTSKGNLSLER.L 2 2.520 0.094 Arabidopsis thaliana chromosome 1 BAC F15K9 sequence, complete sequence; Contains similarity to gb|AB011110 KIAA0538 protein from GP:AC005278_2 K.KDCGEILLKICFSQKNSV.L 2 2.697 0.108 G, O Homo sapiens brain and to phospholipid-binding domain C2 PF|00168. ESTs gb|AA585988 and gb|T04384 come from this gene.. S.VLDLTSSGDQTSASRSPDL.R 2 2.469 0.118 Homo sapiens chromosome 19, cosmid R32516, complete sequence; Hypothetical partial protein; Most similar to YB3C_SCHPO L.EQGKNADFWRDMTTITEDEISKLRKLE. GP:AC005542_1 HYPOTHETICAL 60.9 KD PROTEIN 3 3.876 0.205 A A C2F12.12C IN CHROMOSOME II gnl|PID|e325370 (Z97211) hypothetical protein [Schizosaccharomyces pombe]; Homo sapiens chromosome 19, cosmid R26634, complete sequence; IPI:IPI00215821.1 GP:AC005545_2 Y.RALDIDLDKPL.A 2 3.455 0.092 O vesicle coat component, similar to (98%) alpha and gamma adaptins. Homo sapiens PAC clone RP5- 1049N15 from 7q31.2-7q32, complete IPI:IPI00024767.2 GP:AC006020_2 A.METIDKAKEVGA.T 1 3.287 0.273 G sequence; match to CAA07619; (99%) H_DJ1049N15.2. 2 3.726 0.133 Homo sapiens BAC clone GS1-195F7 from 7q31.2-q32, complete sequence; IPI:IPI00099438.1 GP:AC006029_1 Similar to Sperm Surface Protein PH- S.DMGKNVSATDIEYLAK.V 2 2.769 0.086 P (97%) 20; Similar to P38568 (PID:585674); H_GS195F07.1. Homo sapiens BAC clone RP11- R.RKSVTRPAGSSAVITCDLTVINTFYIHW. GP:AC006033_6 2 2.558 0.245 P 121A8 from 7p14-p13, complete Y Supplementary Table 1 30 sequence; similar to T-cell receptor gamma-chain (V3); similar to PID:g339159. Homo sapiens PAC clone RP4- 672O11 from 7q22-31.2, complete IPI:IPI00164695.2 GP:AC006316_1 E.IPLKARSGSTRL.R 1 2.013 0.101 G sequence; match to AAC51105 (99%) (PID:g1743885); H_DJ0672O11.1. I.ESGLSMVFLKDGERKLCTPSM.D 2 2.530 0.147 Homo sapiens chromosome 14 clone BAC 316E14 map 14q24.3, complete sequence; This CDS is confirmed by ESTs F07900, N64905, AA671559, IPI:IPI00164583.2 GP:AC006530_3 A.RRAGQNSDAGPPRGLTWVPEGA.G 2 2.663 0.095 G, P AI355549, AI341390, AI215680, and (95%) H41018 except for the middle of exon 6. The 'GC' splice sites at 59501- 59502 and 62 E.QLRGCRVVGVIEKVQLV.Q 2 2.530 0.131 L.EHVQGGTLWSHLL.S 1 2.206 0.188 Homo sapiens chromosome 19, cosmid F23842, complete sequence; IPI:IPI00019244.1 GP:AC006540_1 A.GGAAPPPPPPPGAL.G 1 2.138 0.152 P astrocytic NOVA-like RNA-binding (92%) protein [Homo sapiens]. A.GGFLTAEKLAAESAKELVEIAV.P 2 2.730 0.097 Caenorhabditis elegans cosmid Y110A7A, complete sequence; contains similarity to human hypothetical protein KIAA0056 D.LNVSGKAPSSKTKKPTDLLLDEQQIIQK GP:AC006708_21 (SP:P42695) and Arabidopsis thaliana 3 3.559 0.095 O, P FNKLK.L unnamed protein product (GB:Z97339); coded for by the following C. elegans cDNAs: yk7g12.3, yk69 V.LSILQMLCR.D 1 2.042 0.171 Caenorhabditis elegans cosmid Y2C2A, complete sequence; contains GP:AC006731_2 similarity to human silencing mediator E.LSLTAVQR.G 1 1.912 0.095 O, P of retinoic acid and thyroid hormone receptor alpha (GB:AF113003). N.VEEYIQTMIAR.V 2 2.572 0.154 Caenorhabditis elegans cosmid Y49F6B, complete sequence; contains similarity to human acidic 82 kDa GP:AC006790_9 protein (GB:U15552); coded for by the K.SVVGPKFEGDHQPQNRLLGR.N 2 2.467 0.129 A, O following C. elegans cDNAs: yk147g11.5, yk562g10.3, yk562g10.5, yk606f10.5. K.YAEIRQKEQSK.R 2 2.606 0.082 Caenorhabditis elegans cosmid Y50D4A, complete sequence; contain similarity to the human colon cancer- GP:AC006794_2 associated protein Mic1 N.CRFAGNFQIR.Q 2 3.021 0.087 A, G, O, P (gp|AAD33909.1); coded for by the following C. elegans cDNAs: yk26c12.3, yk324g1.5, yk576c6.5. V.CVQDIALNCTSPFREFNNEY.N 2 2.410 0.181 Homo sapiens chromosome 19, GP:AC007059_1 L.EEVAEGVASPDEDEDEE.P 1 2.422 0.084 A cosmid R26549, complete sequence. Homo sapiens chromosome 14 clone RP11-463C8 containing POMT2 gene, partial cds; and unknown genes, IPI:IPI00067744.1 GP:AC007375_1 Y.YSELEEQ.L 1 2.448 0.094 P complete sequence; Genscan- (97%) predicted CDS with BLAST X similarity to KIAA0792 product. Homo sapiens chromosome 14 clone CTD-2207P18 map 14q24.3, complete sequence; latent transforming growth GP:AC013451_1 factor-beta binding protein; Intron- R.EQDAPVAGLQPVERAQPGW.G 2 2.490 0.136 A, P exon boundaries defined in relation to cDNA in Z37976. 5' mRNA start is at 101734. S.PVIENGQLECPQGYK.R 2 2.341 0.148 Homo sapiens chromosome 19, BAC CTB-61I7 (BC52850), complete GP:AC018758_3 sequence; X-ray repair D.NMSDRVQFVITAQEW.D 2 3.126 0.187 A complementing defective repair in Chinese hamster cells 1. Supplementary Table 1 31 Caenorhabditis elegans cosmid Y110A2AR, complete sequence; contains similarity to human polyposis locus-encoded protein (SP:Q00765); GP:AC024748_3 K.QEIVEEDLEIENPADA.T 2 2.552 0.098 A coded for by the following C. elegans cDNAs: yk173h9.3, yk173h9.5, yk267e10.5, yk303a10.3, yk303a10.5, yk309d1.3, yk3 Caenorhabditis elegans cosmid Y47G6A, complete sequence; GP:AC024791_7 A.AQTTNEMRSLR.N 2 2.765 0.139 P contains similarity to human CENP-F kinetochore protein (SP:P49454). Caenorhabditis elegans cosmid Y55B1BR, complete sequence; contains similarity to human LAF-4 GP:AC024824_2 (SP:P51826); coded for by the A.EYEEEQKQPAKPILAK.V 1 2.763 0.140 A, P following C. elegans cDNAs: yk193a11.3, yk193a11.5, yk246b10.3, yk246b10.5. D.VESIVGK.S 1 2.000 0.203 Caenorhabditis elegans cosmid Y71G12A, complete sequence; similar to pir||I38919 probable transmembrane protein - human GP:AC024857_3 L.INIFPDAGVDQ.S 1 2.496 0.107 G gp|AAC50134.1, S=220, E=3.6e-14 rew; coded for by the following C. elegans cDNAs: yk47c9.5, yk191g7.5, yk270h3.5, yk346a2.5, yk406 Homo sapiens T-cell receptor alpha delta locus from bases 501613 to GP:AE000660_13 752736 (section 3 of 5) of the Y.SVHWYRQK.H 1 1.948 0.144 G Complete Nucleotide Sequence; Old name TCRAV29S1. Homo sapiens 16p13.3 sequence section 2 of 8; Structure of CDS L.GGCGSAARSGRGAGRGGAAGAQPPA GP:AE006463_5 predicted by GENSCAN; confirmed by 2 2.895 0.150 G, P P.T conservation of genomic sequence in Chicken. R.GAGRGGAAGAQPPAP.T 1 2.052 0.155 Homo sapiens 16p13.3 sequence section 3 of 8; Peptide sequence GP:AE006464_2 A.WEPLAPASMLGLEGPCWVGPG.P 2 2.799 0.177 O, P identity with SP:Q13049; Structure of CDS predicted by GENSCAN. Homo sapiens 16p13.3 sequence M.HGRSYSLASGAGGGGSKGNSLKRSK. IPI:IPI00045478.1 GP:AE006464_4 2 2.769 0.144 O section 3 of 8; S (91%) Homo sapiens 16p13.3 sequence section 6 of 8; Structure of CDS IPI:IPI00000137.1 GP:AE006467_3 K.VVEEPNAFGVNNPFLPQASR.L 2 3.656 0.320 O predicted by GENSCAN; Peptide (91%) sequence identity with TR:Q9UJJ9. Homo sapiens 16p13.3 sequence GP:AE006639_2 section 7 of 8; Peptide sequence A.RGQVKCPRSGAEGKGVGRPPPAA.D 2 2.567 0.120 G, P identity with GP:Y13674_1. D.KNTFFEGLYEHGK.D 1 2.077 0.104 Homo sapiens 16p13.3 sequence GP:AE006640_3 F.PQALIVGV.K 1 2.107 0.091 A section 8 of 8; PubMed:9988767. Homo sapiens TTF-I interacting peptide 20 mRNA, partial cds; TIP20; E.EAWSPGPLDSEDQQMASHENPVDILI. GP:AF000560_1 3 4.069 0.163 P Transcription Termination Factor I M Interacting Peptide 20. Homo sapiens clone 1 immunoglobulin-like transcript 4 mRNA, complete cds; immunoglobulin IPI:IPI00166017.1 GP:AF000574_1 L.ELLVPGV.S 1 2.001 0.143 O superfamily; inhibitory receptor (91%) expressed by myeloid antigen presenting cells; ILT4. Homo sapiens anti-CD34 Ig light chain GP:AF001792_1 variable region mRNA, partial cds; R.VSWYQQPPGTAPK.L 1 2.174 0.196 G, O, P anti-CD34. 2 3.415 0.285 Caenorhabditis elegans cosmid F37E3, complete sequence; strong similarity tothe human CAP-binding protein (NID:g563368); coded for by GP:AF003132_1 L.VGLLNSKNFNFGGDVV.E 1 2.221 0.093 G the following C. elegans cDNAs: cm04h12, cm08c7, yk25b1.3, CEESE96F, yk193b6.3, yk218g8.3, yk220e9.3, yk285c10.3, yk Supplementary Table 1 32 Homo sapiens immunoglobulin kappa- GP:AF003380_1 chain variable region mRNA, partial -.ENVLTQSPATLSLSPGDR.A 2 3.906 0.361 O cds. Homo sapiens Jagged 2 mRNA, complete cds; ligand for Notch GP:AF003521_1 E.CEGKPCLNAFSCKNLIGGYYC.D 2 3.118 0.125 G, O, P receptor; Contains EGF repeats and DSL domain. P.AGHAAVREDEEDEDLGRGEED.S 2 3.417 0.156 Homo sapiens anti-melanoma Ig heavy chain variable region mRNA, IPI:IPI00220120.1 GP:AF004324_1 -.EVQLVQSGGGLVQPGGSLR.L 2 3.944 1.000 G, O, P partial cds; anti-melanoma scFv (96%) molecule. Saccharomyces cerevisiae Stp22p (STP22) gene, complete cds; similar GP:AF004731_1 to the mouse and human Tsg101 V.KPPFISINLE.N 1 2.047 0.124 P tumor susceptibility gene; mutants exhibit a Class E Vps phenotype. Homo sapiens 54TMp (54tm) mRNA, IPI:IPI00007607.1 GP:AF004876_1 complete cds; putative R.LQLYLTLGA.A 1 1.997 0.091 G (92%) transmembrane protein. Homo sapiens rearranged IPI:IPI00178741.1 GP:AF004938_1 immunoglobulin heavy chain variable E.NYADSVK.G 1 2.054 0.105 G (93%) region (ML11-VH3) mRNA, partial cds. Homo sapiens rearranged GP:AF004940_1 immunoglobulin heavy chain variable Y.SGSTYYNPSLR.S 2 2.616 0.231 G region (ML13-VH4) mRNA, partial cds. Homo sapiens immunoglobulin heavy GP:AF006517_1 chain variable region mRNA, partial T.YYAESVK.G 1 2.067 0.243 G cds. Homo sapiens immunoglobulin heavy GP:AF006521_1 chain variable region mRNA, partial K.NTVYLEMNSLR.A 1 2.382 0.120 G cds. Homo sapiens immunoglobulin heavy IPI:IPI00173849.1 GP:AF006522_1 chain variable region mRNA, partial -.QVQLVESGGGLVQPGGSLR.L 1 3.480 1.000 G, O, P (94%) cds. 2 3.572 1.000 K.GLEWVSVIYSDGR.T 2 2.242 0.236 K.NTLFLQMN.S 1 2.341 0.185 K.NTLFLQMNSLR.A 2 4.037 0.299 Homo sapiens immunoglobulin heavy GP:AF006524_1 chain variable region mRNA, partial N.NTLYLQMDSLR.T 1 2.460 0.173 G, O, P cds. 2 4.047 0.102 N.TLYLQMDSLR.T 2 2.312 0.109 Homo sapiens immunoglobulin heavy GP:AF006526_1 chain variable region mRNA, partial -.EVHLLESGGGLVQPGGSLR.L 2 5.206 0.575 G cds. T.YYTDSVK.G 1 2.136 0.239 Homo sapiens Trip230 mRNA, IPI:IPI00003515.1 GP:AF007217_1 E.ECLAGNNQLSLEKNTI.V 1 2.715 0.082 G, O, P complete cds. (91%) Q.VLQIEK.V 1 2.138 0.081 R.EEQSRTAPVADPKTLDSVTE.L 2 3.630 0.282 Homo sapiens anti-DNA antibody 18/2, immunoglobulin kappa light IPI:IPI00178276.1 GP:AF007572_1 chain V region (Vkappa Jkappa) R.NDLGWYQQ.K 1 2.255 0.172 G (93%) mRNA, partial cds; anti-DNA antibody 18/2. R.NDLGWYQQK.P 1 2.732 0.273 2 2.540 0.244 R.NDLGWYQQKPGK.A 1 2.197 0.294 2 3.960 1.000 Homo sapiens EVI5 homolog mRNA, IPI:IPI00029661.1 GP:AF008915_1 complete cds; similar to tre-2 A.YSLVDREVGYCQ.G 2 2.670 0.095 G (91%) oncogene and TBC1. Homo sapiens receptor-associated coactivator 3 (RAC3) mRNA, complete GP:AF010227_1 cds; transcriptional coactivator with V.SSTGQGVIDKDSLGPLLLQALDG.F 2 3.052 0.083 A, O intrinsic histone acetyltransferase activity; member of th. Homo sapiens DEC-205 mRNA, GP:AF011333_1 complete cds; putative antigen-uptake K.YNVSSLEK.Y 1 2.243 0.102 A, G receptor on dendritic cells. L.GAHLSSFSHVDE.I 1 2.005 0.144 GP:AF011750_1 Mus musculus Ymp mRNA, complete L.WYDCTWNTTTQ.T 2 3.002 0.091 G Supplementary Table 1 33 cds; similar to human YMP encoded by GenBank Accession Number U52101. Homo sapiens eIF4GII mRNA, GP:AF012072_1 complete cds; eIF4GI functional L.NKLTPQMFNQLMK.Q 2 2.385 0.226 A, G, P homolog. P.AFADFGRQTPGGRGVPLLNVGSRR.S 2 2.225 0.175 P.GPGDFPNAYGTPFYPS.Q 2 3.235 0.170 R.ADQGPKTIEQIHKEAKIEEQEE.Q 3 3.700 0.089 Homo sapiens immunoglobulin heavy GP:AF013616_1 chain variable region (VH4) mRNA, S.RVPLQESGPGL.V 1 2.523 0.096 G, O, P VH4-31 allele, partial cds. 2 3.271 0.135 S.RVPLQESGPGLVK.P 1 2.584 0.333 2 4.186 0.354 S.RVPLQESGPGLVKPS.Q 2 3.848 0.395 Homo sapiens immunoglobulin heavy GP:AF013619_1 chain variable region (VH4) mRNA, Q.GTPVTVSSASTK.G 1 2.098 0.114 G VH4-31 allele, partial cds. 2 2.642 0.125 S.QLQLKESGPR.L 2 2.896 0.207 W.GQGTPVTVSSASTK.G 2 3.241 0.336 Homo sapiens immunoglobulin heavy GP:AF013622_1 chain variable region (VH4) mRNA, R.GALVTVSSASTK.G 1 2.243 0.281 G, O VH4-39 allele, partial cds. 2 3.552 0.345 R.VTISIDTSK.N 1 1.989 1.000 T.YYTNPSLK.N 1 1.925 0.084 Homo sapiens immunoglobulin heavy GP:AF013623_1 chain variable region gene, partial cds; R.IYTSGSTNYNPSLK.S 2 2.964 0.308 G similar to VH4 allele VH4-34. Homo sapiens IgG heavy chain IPI:IPI00220120.1 GP:AF015126_1 variable region (Vh26) mRNA, partial K.DTLYLQMN.S 1 2.358 0.153 G, O (92%) cds. K.DTLYLQMNSLK.A 1 3.033 0.188 K.GLEWVSSIGGSDGSTDYADSVK.G 2 4.061 0.175 K.GTTVTVSLASTK.G 1 1.916 0.244 2 2.228 0.195 Homo sapiens IgG heavy chain GP:AF015127_1 variable region (Vh26) mRNA, partial S.TNYADSVK.G 1 2.101 0.246 G cds. Homo sapiens IgG heavy chain GP:AF015129_1 variable region (Vh26) mRNA, partial K.NTLFLQMNSLTA.E 2 2.915 0.127 G, O cds. T.TYYAGSVK.G 1 1.980 0.168 Homo sapiens IgG heavy chain IPI:IPI00220120.1 GP:AF015130_1 variable region (Vh26) mRNA, partial R.DNSKNTLYLQMNSLTA.E 2 3.102 0.341 G (97%) cds. Homo sapiens IgG heavy chain GP:AF015140_1 variable region (Vh6) mRNA, partial I.FDYWGQGTLVTVSSASTK.G 2 3.329 0.181 G cds. Homo sapiens IgG heavy chain GP:AF015144_1 variable region (Vh6) mRNA, partial R.QSPSGGLEWLGR.T 2 2.737 0.282 G cds. Homo sapiens nucleolar protein GP:AF015308_1 N.DLTSVHLGVK.F 2 2.621 0.106 P (MSP58) mRNA, complete cds. Homo sapiens retinoblastoma- IPI:IPI00005791.1 GP:AF017790_1 associated protein HEC mRNA, A.KNRALNEQIARLE.Q 1 2.258 0.106 G (95%) complete cds; nuclear protein. Homo sapiens T cell receptor alpha chain (TCRA) mRNA, partial cds; T GP:AF018170_1 S.DSAVYFCALSGRSGNTPL.V 1 2.177 0.111 G cell receptor V alpha 22, J alpha 9.14, C alpha. Synthetic construct RSV neutralizing human Ig lambda chain with leader (IgL) mRNA, complete cds; human lambda light chain with leader; Binds GP:AF018265_1 W.VFGGGTKLTVLGQPK.A 2 2.686 0.201 G to RSV F1 subunit at an epitope conformationally affected by aa substitution at aa429. Neutralizes RSV. Synthetic construct RSV neutralizing IPI:IPI00004617.1 GP:AF019036_1 K.AKGQPREPQVYTLPPSREEMTK.N 3 4.818 0.214 G, O, P human Ig gamma chain with leader (91%) Supplementary Table 1 34 mRNA, complete cds. K.GQPREPQVYTLPPSREEMTK.N 2 2.675 0.103 3 4.443 0.187 K.KSLSPKSCDKTHTCPPCPAPELLGGPS 3 3.550 0.239 VFLFPPKPK.D L.PPSREEMTK.N 1 2.219 0.182 2 2.618 0.328 Q.VYTLPPSREEMTK.N 2 2.881 0.301 R.EPQVYTLPPSREEM.T 1 2.893 0.299 R.EPQVYTLPPSREEMTK.N 1 3.659 0.180 2 3.436 0.345 V.YTLPPSREEMTK.N 2 2.827 0.206 Homo sapiens bromodomain protein (BRDT) mRNA, complete cds; IPI:IPI00018390.1 GP:AF019085_1 L.RELEKYVSACLR.K 1 2.208 0.222 G, P bromodomain protein, testis specific; (91%) probable transcription co-factor. 2 2.731 0.139 Homo sapiens rearranged GP:AF019141_1 immunoglobulin heavy chain variable K.NHFSLK.V 1 1.971 0.145 G region mRNA, partial cds. Homo sapiens CD20-binding IgG1, Ig heavy chain VH1 region (IgH) mRNA, GP:AF019639_1 partial cds; IgG1 VH1 region with A.GWFDPWGQGTLVTVSSASTK.G 2 2.562 0.164 G partial CH1 domain; binds to human CD20 antigen ectodomain. Homo sapiens CD20-binding IgG1, Ig heavy chain VH3 region (IgH) mRNA, GP:AF019640_1 partial cds; IgG1 VH3 region with K.GPSVFPLAPTSK.S 2 2.728 0.187 G partial CH1 domain; binds to human CD20 antigen ectodomain. K.GPSVFPLAPTSKSTS.G 2 2.577 0.086 Homo sapiens CD20-binding IgG1, Ig heavy chain VH6 region (IgH) mRNA, GP:AF019642_1 partial cds; IgG1 VH6 region with F.LSWFDPWGQGTLVTVSSASTK.G 2 4.486 0.325 G partial CH1 domain; binds to human CD20 antigen ectodomain. Homo sapiens chromosome- GP:AF020043_1 associated polypeptide (HCAP) K.LDQDLNEVKAR.V 1 2.301 0.084 G, O, P mRNA, complete cds; SMC family. L.RAATGKAILNGIDSINKVLDHFRRKGIN 3 3.866 0.133 QHVQNG.Y Homo sapiens Munc13 mRNA, complete cds; contains C2 domains; S.PDARASAAQDADSVLRPLMDFLDGNL IPI:IPI00183768.1 GP:AF020202_1 similar to R. norvegicus Munc13-2 3 4.032 0.141 O TLFATV.C (97%) encoded by GenBank Accession Number U24071. Homo sapiens T cell receptor alpha GP:AF020636_1 chain variable region (AV4S1) mRNA, I.FGTGTRLQVFPNIQNPDPAVYQ.L 2 3.090 0.087 P partial cds. Homo sapiens clone CD20-43 immunoglobulin lambda chain (VL4) GP:AF021037_1 Y.YASWYQKK.P 2 2.506 0.100 G mRNA, partial cds; V-region; binds to human CD20 ectodomain. Homo sapiens clone CD20-24A immunoglobulin kappa chain (VK3) GP:AF021039_1 R.FSGSGSGTDFTLTITR.V 2 4.164 0.256 G mRNA, partial cds; V-region; binds to human CD20 ectodomain. R.VAWYQHK.P 1 1.868 0.137 Homo sapiens ID:CLL097 IgA heavy GP:AF021940_1 chain variable region mRNA, partial M.GWINTNTGNPTYAQGFTGR.F 2 3.496 0.506 G cds. Homo sapiens ID:CLL017 IgM heavy GP:AF021952_1 chain variable region mRNA, partial R.IIPILGIANYAQK.F 2 3.877 0.206 G cds. Homo sapiens ID:CLL018 IgM heavy GP:AF021953_1 chain variable region mRNA, partial -.EVHLVESGGGLVQPGGSLR.L 1 2.345 0.211 G, P cds. 2 5.637 0.550 3 3.903 0.248 Homo sapiens ID:CLL026 IgM heavy IPI:IPI00018563.3 GP:AF021959_1 chain variable region mRNA, partial M.PGKGLEWMGR.I 1 1.976 0.128 G (91%) cds. Q.GHVTISADK.S 1 2.498 0.270
Supplementary Table 1 35 R.IDPSDSYTNYSPSFQGHVT.I 2 4.129 0.412 Homo sapiens ID:CLL038 IgM heavy GP:AF021962_1 chain variable region mRNA, partial -.EVQLVESGGDLVQ.P 2 3.359 0.134 G, O, P cds. -.EVQLVESGGDLVQPGGSLR.L 1 3.172 0.134 2 4.972 0.371 Q.LVESGGDLVQPGGSLR.L 2 3.826 0.376 Homo sapiens ID:CLL065 IgM heavy GP:AF021976_1 chain variable region mRNA, partial R.TSSFATAYAASVKGR.F 2 2.825 0.274 G cds. Homo sapiens ID:CLL081 IgM heavy GP:AF021979_1 chain variable region mRNA, partial -.EVQLVEAGGGLVQPGGSLR.L 2 3.867 0.305 G, O, P cds. K.NSLYLQMDSLR.D 1 2.326 0.191 2 3.893 0.262 N.SLYLQMDSLR.D 2 2.557 0.132 Homo sapiens ID:CLL088 Ig heavy GP:AF021982_1 chain variable region mRNA, partial -.EVQLVQSGAELK.K 1 3.686 0.216 G cds. 2 3.658 0.189 Homo sapiens ID:CLL099 Ig heavy GP:AF021984_1 chain variable region mRNA, partial K.YSQNFQGR.L 1 1.932 0.121 G cds. Homo sapiens ID:CLL108 Ig heavy GP:AF021987_1 chain variable region mRNA, partial A.VQLVESGGGLAQPGGSLRLSCATS.G 2 2.728 0.212 A cds. Homo sapiens ID:CLL110 Ig heavy GP:AF021988_1 chain variable region mRNA, partial -.QVHLVQSGAEVK.K 2 2.942 0.093 G, P cds. W.INPNTGGTNYAQK.F 2 2.443 0.261 Homo sapiens ID:CLL113 Ig heavy GP:AF021989_1 chain variable region mRNA, partial L.IYWDDDK.R 1 1.853 0.082 G cds. L.IYWDDDKR.Y 2 2.504 0.274 Homo sapiens ID:CLL126 Ig heavy IPI:IPI00182107.1 GP:AF021998_1 chain variable region mRNA, partial -.EVELVESGGDLVQPGGSLR.L 2 2.637 0.271 G, P (91%) cds. 3 3.775 0.182 Homo sapiens ID:CLL138 Ig heavy GP:AF022003_1 chain variable region mRNA, partial K.NTLYLHMN.N 1 1.910 0.177 G cds. Homo sapiens ID:CLL153 Ig heavy GP:AF022008_1 chain variable region mRNA, partial K.NTIYLQMN.S 1 2.547 0.207 A, G, O, P cds. K.NTIYLQMNSLR.A 2 4.180 1.000 Homo sapiens ID:CLL200 Ig heavy GP:AF022010_1 chain variable region mRNA, partial -.EVQIVESGGGL.V 1 2.561 0.298 G, O cds. -.EVQIVESGGGLVQ.P 2 3.512 0.126 -.EVQIVESGGGLVQPGGSVR.L 2 3.680 0.199 K.GLEWVANINPDGSEK.N 2 2.283 0.269 K.NYVDSVK.G 1 2.204 0.179 Drosophila melanogaster putative KP78 protein kinase (KP78A) and GP:AF023484_1 putative KP78 protein kinase (KP78B) L.GMVLYTLVSGSLPFDGGTLKELRE.R 2 2.881 0.111 O, P genes, complete cds; similar to human KP78 protein kinase. T.PPRFQYPVAQTPNQAQGSSR.R 2 2.297 0.101 Homo sapiens immunoglobulin kappa light chain mRNA, partial cds; GP:AF026381_1 K.DSTYSLSSTLTX.S 1 1.828 0.094 A, G, O, P antiphospholipid isotype IgG2 antibodies; Fab fragments. 2 4.418 0.377 K.DSTYSLSSTLTXSK.A 1 3.431 0.304 2 4.246 0.421 K.VDNALQSGNSQESVTEQDSKDSTYSL 3 3.661 0.301 SSTLTX.S K.VDNALQSGNSQESVTEQDSKDSTYSL 3 3.767 0.311 SSTLTXS.K K.VDNALQSGNSQESVTEQDSKDSTYSL 2 3.806 0.374 SSTLTXSK.A 3 5.969 0.490
Supplementary Table 1 36 K.VQWKVDNALQSGNSQESVTEQDSKD 3 5.003 0.336 STYSLSSTLTXSK.A Q.SGNSQESVTEQDSKDSTYSLSSTLTXS 2 2.756 0.245 K.A Homo sapiens cofactor of initiator IPI:IPI00182890.1 GP:AF026445_1 function (CIF150) mRNA, complete L.VLNLKEK.K 1 2.031 0.093 P (95%) cds; similar to Drosophila dTAF150. Homo sapiens amyloid lambda light GP:AF026920_1 chain variable region mRNA, partial N.YVSWYQQK.P 1 2.387 0.271 G cds. Homo sapiens amyloid lambda light GP:AF026922_1 chain variable region mRNA, partial H.SNYAIAWHQQQPEK.G 2 2.596 0.188 G, O cds. I.KGDGIPDR.F 2 3.063 0.218 R.FSGSSSGAER.Y 1 2.033 0.343 Y.AIAWHQQQPEK.G 2 2.934 0.316 Homo sapiens amyloid lambda light GP:AF026925_1 chain variable region mRNA, partial W.DSSAAFFGGGTK.L 1 2.303 0.123 G cds. Homo sapiens amyloid kappa light GP:AF026929_1 chain variable region mRNA, partial G.ELVMTQSPDSLAVSLGER.A 2 2.283 0.135 G cds. P.GFTFGPGTK.V 1 1.809 0.262 Homo sapiens alpha heavy chain GP:AF026931_1 variable region mRNA from amyloid E.HLVESGGGVVQPGR.S 2 2.554 0.255 G patient, partial cds. E.WVAVMSHDKTNQYYADSVK.G 2 2.485 0.230 Homo sapiens i-beta-1,3-N- acetylglucosaminyltransferase mRNA, IPI:IPI00009997.1 GP:AF029893_1 complete cds; glycosyltransferase; Y.VAGGKVPTFDER.F 1 1.988 0.249 G (93%) poly-N-acetyllactosamine extension enzyme i-antigen; iGnT. GP:AF030347_1 Homo sapiens Ig VH gene, partial cds. L.IDWDDDKYYTTSLK.T 2 3.719 0.436 G Homo sapiens clone HCL3 Ig VH IPI:IPI00182107.1 GP:AF030348_1 K.FYVDSVK.G 1 2.443 0.209 G gene, partial cds. (94%) Homo sapiens variable IPI:IPI00154742.1 GP:AF032355_1 immunoglobulin anti-HLA lambda light N.SNRPSGVPDR.F 2 2.573 0.133 G (97%) chain (Ig lambda) mRNA, partial cds. Homo sapiens variable IPI:IPI00003457.1 GP:AF032359_1 immunoglobulin anti-HLA kappa light K.ASTLESGVPSR.F 1 2.062 0.309 G, O, P (94%) chain (Ig kappa) mRNA, partial cds. 2 3.300 0.247 Homo sapiens variable GP:AF032360_1 immunoglobulin anti-HLA heavy chain R.QAPGKGLEWVSGISWNSLNIGYAD.S 2 3.387 0.114 G (IgH) mRNA, partial cds. Homo sapiens variable IPI:IPI00181894.1 GP:AF032361_1 immunoglobulin anti-HLA kappa chain E.YNSAPLTFGGGTK.V 2 2.476 0.142 G (94%) (Ig kappa) mRNA, partial cds. I.SNYLAWYQQK.P 2 3.979 0.133 N.YLAWYQQKPGKVPK.L 2 3.427 1.000 R.ASQGISNYLAWYQQK.P 2 2.909 0.117 R.ASQGISNYLAWYQQKPGK.V 2 3.347 0.094 Homo sapiens potassium channel IPI:IPI00175643.1 GP:AF032897_1 subunit (HERG-3) mRNA, complete V.VAILGKNDIFGEMVHLYA.K 2 3.040 0.177 G (91%) cds. Homo sapiens Siva-2 mRNA, complete cds; putative alternate splice form of Siva encoded by GenBank GP:AF033111_1 A.SIACSSCVRAVDGK.A 1 1.815 0.197 P Accession Number U82938; appears to lack the apoptotic properties of Siva. Homo sapiens clone B2C2G4H myosin-reactive immunoglobulin IPI:IPI00009792.1 GP:AF035019_1 -.EVQLVESGAEVK.K 1 3.440 0.253 G, O, P heavy chain variable region mRNA, (92%) partial cds; autoantibody. 2 3.614 0.191 E.VQLVESGAEVK.K 1 2.495 0.179 2 3.297 0.195 Q.LVESGAEVK.K 1 2.350 0.133 Homo sapiens clone MCE11H myosin-reactive immunoglobulin GP:AF035024_1 K.GLEWVAFIR.Y 2 2.842 0.222 G heavy chain variable region mRNA, partial cds; autoantibody. GP:AF035028_1 Homo sapiens clone B2E9D5K -.EIVLTQSPGTL.S 1 3.112 0.248 G, P IPI:IPI00003486.1 Supplementary Table 1 37 myosin-reactive immunoglobulin (93%) kappa chain variable region mRNA, partial cds; autoantibody. 2 4.099 0.236 -.EIVLTQSPGTLSL.F 2 3.712 0.264 -.EIVLTQSPGTLSLFPGER.A 2 2.339 0.145 R.FSGSGSETDFTLTISR.L 2 2.817 0.380 Homo sapiens clone MC56K myosin- reactive immunoglobulin kappa chain GP:AF035029_1 W.ASQSISSNLAWYQQK.P 2 2.898 0.224 G variable region mRNA, partial cds; autoantibody. W.ASQSISSNLAWYQQKPGQAPR.L 2 3.327 0.138 Homo sapiens clone MC57H myosin- reactive immunoglobulin heavy chain GP:AF035030_1 -.EVQLVESGGGVVQPGR.S 2 4.274 0.204 O variable region mRNA, partial cds; autoantibody. Homo sapiens clone MC57K myosin- reactive immunoglobulin light chain IPI:IPI00141670.1 GP:AF035031_1 Q.SVSSNLAWYQQK.P 2 3.586 0.200 G, O, P variable region mRNA, partial cds; (92%) autoantibody. R.ASQSVSSNLAWYQQK.P 1 3.875 0.303 2 4.485 0.244 R.ASQSVSSNLAWYQQKPGQAPR.L 2 4.990 0.200 3 4.766 0.232 Homo sapiens clone MCA1L myosin- reactive immunoglobulin light chain GP:AF035032_1 -.SYELTQPSSVSVSPGQTAR.I 2 3.266 0.427 G, O, P variable region mRNA, partial cds; autoantibody. K.DTERPSGIPER.F 1 2.196 0.130 2 2.423 0.126 K.PGQAPILVIFK.D 2 3.257 0.352 S.YELTQPSSVSVSPGQTAR.I 1 2.315 0.286 2 4.961 0.554 Homo sapiens clone MCE1K myosin- reactive immunoglobulin light chain IPI:IPI00026195.1 GP:AF035034_1 R.DSGVPDRFSGSGSGTDFTLK.I 2 3.475 0.293 G, O variable region mRNA, partial cds; (96%) autoantibody. R.RLIYKVSNR.D 2 3.461 0.221 Homo sapiens clone S3F5H myosin- reactive immunoglobulin heavy chain GP:AF035040_1 P.VPSRGLEWLGR.T 1 1.920 0.134 G variable region mRNA, partial cds; autoantibody. 2 3.130 0.128 Homo sapiens clone 23742 mRNA, GP:AF035287_1 partial cds; similar to synaptic A.EDSGEYHCVYHFVSAPK.A 2 2.545 0.155 A membrane glycoprotein. Homo sapiens rheumatoid factor RF- GP:AF035789_1 I.KSKTYGGTTDYAAPVK.G 2 3.367 0.435 G, O IP10 mRNA, partial cds. K.TYGGTTDYAAPVK.G 2 3.852 0.475 Homo sapiens rheumatoid factor RF- IPI:IPI00180166.1 GP:AF035798_1 K.ADGGTTDYAAPVK.G 2 3.847 0.266 G ET9 mRNA, partial cds. (94%) Homo sapiens collagen type IX alpha 1 chain (COL9A1) gene, long and IPI:IPI00220157.1 GP:AF036130_1 G.EPGKPGPPGDAGLHGL.P 2 2.843 0.135 O short alternatively spliced forms, exon (91%) 38 and complete cds. Homo sapiens paraneoplastic IPI:IPI00005685.1 GP:AF037364_1 neuronal antigen MA1 (MA1) mRNA, R.ILKSNNPAITTAECLKALEQVFGS.V 2 2.577 0.081 G (96%) complete cds. L.GVVPYACVGLGGNFVGVVDGHITPK.L 2 2.270 0.112 Homo sapiens MA-2 immunoglobulin IPI:IPI00182107.1 GP:AF038443_1 A.RGDYYDSGSFVDA.F 2 2.661 0.085 G heavy chain gene, partial cds. (97%) Homo sapiens LE-2 immunoglobulin IPI:IPI00182107.1 GP:AF038444_1 K.GLEWVANIKPDGSEK.Y 2 3.782 0.401 P heavy chain gene, partial cds. (97%) Homo sapiens antigen NY-CO-1 (NY- GP:AF039687_1 S.KNVAAVQPMKRGQK.S 2 2.655 0.115 G CO-1) mRNA, complete cds. Homo sapiens unknown protein IT1 K.DRSLPAVVRENAQLLNMPVVKGDFDL IPI:IPI00029372.1 GP:AF040964_1 3 3.640 0.084 O, P mRNA, partial cds. QIAK.Q (98%) Homo sapiens I-FLICE isoform 4 IPI:IPI00219241.1 GP:AF041461_1 M.FFIQNYVVSEGQLEDSSF.L 2 3.061 0.135 O, P mRNA, complete cds. (99%) Plasmodium falciparum erythrocyte binding protein homolog mRNA, GP:AF042160_1 D.IIELHTYSTQILK.Y 2 2.548 0.140 G, P partial cds; Pf2B antigen that as a fusion protein with lambda phage Supplementary Table 1 38 beta-galactosidase is specifically reactive with human sera from Plasmodium falciparum infected Gambian individuals a I.FNLYIKCSEQQNIIDDSYNYITV.K 2 2.689 0.086 K.KVDELKNYLNNIK.E 2 3.199 0.131 Homo sapiens spindle pole body protein spc98 homolog GCP3 mRNA, IPI:IPI00221174.1 GP:AF042378_1 complete cds; component of S.SQATTSKGVPSAVSR.N 2 2.510 0.208 G (95%) cytoplasmic gamma-tubulin complex; localized to the centrosome. Homo sapiens actin-binding protein IPI:IPI00029489.2 GP:AF043045_1 homolog ABP-278 mRNA, complete G.EHLVSIKK.N 1 2.210 0.090 G, O, P (99%) cds; homolog of ABP-280. T.ATPEIVDNKDGTVTVRY.A 1 2.076 0.080 Homo sapiens T cell receptor beta GP:AF043183_1 chain (TCRBV3S1-TCRBJ2S3) S.RYLVKRTGEK.V 2 2.740 0.113 G mRNA, complete cds. Homo sapiens epidermal filaggrin GP:AF043380_1 A.SSQEQARSSPGERHGS.R 2 2.406 0.154 A, O gene, partial cds. R.HSQVGQGESAGSK.T 2 2.358 0.236 Homo sapiens delayed-rectifier K+ channel alpha subunit (KCNS1) IPI:IPI00102065.1 GP:AF043473_1 E.LCVFAFGQEADYWGLGENA.L 2 2.959 0.100 A mRNA, complete cds; alternatively (95%) spliced; electrically silent. G.CILGGILVVA.L 1 2.082 0.089 Homo sapiens clone ASMneg1-b3 immunoglobulin lambda chain VJ GP:AF043583_1 G.NTDRPSGVPDR.F 2 2.715 0.093 G, O, P region, (IGL) mRNA, partial cds; VJ region. T.DRPSGVPDRFSGSKSGISASLAITGL.Q 2 2.865 0.200 Homo sapiens clone CSRF1-5 immunoglobulin lambda chain VJ IPI:IPI00179702.1 GP:AF043588_1 Y.NVHWYQQ.L 1 2.461 0.215 G region, (IGL) mRNA, partial cds; VJ (95%) region. Synthetic construct from Homo sapiens clone D12 anti-Rh(D) GP:AF044435_1 antibody VH segment mRNA, partial K.NTLYLEMNSLR.V 1 2.391 1.000 G, O, P cds; gamma 1 heavy chain variable region. 2 4.113 1.000 Synthetic construct from Homo sapiens clone E01 anti-Rh(D) antibody GP:AF044445_1 -.EVQLLESGGGLVKPGGSLR.L 1 3.777 1.000 G, O, P VH segment mRNA, partial cds; gamma 1 heavy chain variable region. 2 5.583 1.000 Q.LLESGGGLVKPGGSLR.L 1 2.126 0.157 2 4.445 0.335 Synthetic construct from Homo sapiens clone F01 anti-Rh(D) antibody GP:AF044447_1 Y.ATSSLQSGVPSR.F 2 2.628 0.220 G V kappa segment mRNA, partial cds; kappa light chain variable region. Synthetic construct from Homo sapiens clone G01 anti-Rh(D) GP:AF044448_1 antibody V kappa segment mRNA, A.LQFPLTFGGGTK.V 1 1.991 0.224 G partial cds; kappa light chain variable region. Synthetic construct from Homo sapiens clone I04 anti-Rh(D) antibody GP:AF044453_1 N.TPWTFGQGTK.V 1 2.315 0.177 G V kappa segment mRNA, partial cds; kappa light chain variable region. Synthetic construct from Homo sapiens clone J01 anti-Rh(D) antibody GP:AF044465_1 N.RPSGIPGRFSGSSSGQTAA.L 2 2.936 0.326 A V lambda segment mRNA, partial cds; lambda light chain variable region. Synthetic construct from Homo sapiens clone J04 anti-Rh(D) antibody IPI:IPI00017248.1 GP:AF044467_1 K.PGQAPVLVIYGKNS.R 2 3.590 0.317 G V lambda segment mRNA, partial cds; (92%) lambda light chain variable region. Synthetic construct from Homo sapiens clone L01 anti-Rh(D) antibody GP:AF044472_1 A.SNTVNWYQQLPGTAPK.L 2 3.061 0.240 G, O V lambda segment mRNA, partial cds; lambda light chain variable region. E.LTQPPSASGTPGQR.V 1 2.922 0.249 2 2.791 0.196 Supplementary Table 1 39 K.LLIYSNNQR.P 2 2.395 0.126 K.LLIYSNNQRPSGVPDR.F 2 2.831 0.105 L.LIYSNNQRPSGVPDR.F 2 2.947 0.119 L.TQPPSASGTPGQR.V 2 2.208 0.262 N.TVNWYQQLPGTAPK.L 1 2.723 0.202 2 3.586 0.139 Q.PPSASGTPGQR.V 1 2.510 0.343 2 2.382 0.264 S.NTVNWYQQLPGTAPK.L 2 3.949 0.311 Synthetic construct from Homo sapiens clone L04 anti-Rh(D) antibody GP:AF044474_1 N.IGSNTVNWYQQLPGTAPK.L 2 4.212 0.287 G, P V lambda segment mRNA, partial cds; lambda light chain variable region. Synthetic construct from Homo sapiens clone N01 anti-Rh(D) GP:AF044479_1 antibody V lambda segment mRNA, N.YVSWYQQLPGTAPK.L 2 2.229 0.224 G, O, P partial cds; lambda light chain variable region. Q.TGDEADYYCATWDDSLNGRVF.G 2 3.048 0.173 S.NYVSWYQQLPGTAPK.L 1 2.012 0.128 2 4.150 0.416 Synthetic construct from Homo sapiens clone N02 anti-Rh(D) GP:AF044480_1 antibody V lambda segment mRNA, N.IGNNYVSWYQQLPGTAPK.L 2 3.725 0.391 G partial cds; lambda light chain variable region. S.SNIGNNYVSWYQQLPGTAPK.L 2 3.933 0.371 Synthetic construct from Homo sapiens clone P01 anti-Rh(D) antibody GP:AF044484_1 M.SGQAPVLVIYEDK.K 2 3.316 0.292 G, O V lambda segment mRNA, partial cds; lambda light chain variable region. Synthetic construct from Homo sapiens clone S01 anti-Rh(D) antibody GP:AF044487_1 S.DVGNYNLVSWYQQYPGK.A 2 4.394 0.421 G V lambda segment mRNA, partial cds; lambda light chain variable region. Homo sapiens lymphocyte- predominant Hodgkin's disease case GP:AF044598_1 #10 immunoglobulin heavy chain K.DSLYLQM.N 1 2.078 0.202 G, P gene, variable region, partial cds; VH gene family III; VDJ rearrangement. K.DSLYLQMN.S 1 2.122 0.125 K.DSLYLQMNSLR.A 1 2.126 0.107 Homo sapiens aldose reductase- GP:AF044961_1 related protein mRNA, partial cds; I.QVFDFKLSDEE.M 2 3.076 0.128 P HARP; overexpressed in hepatomas. Mus musculus anti-human ovarian carcinoma antibody heavy chain GP:AF045023_1 -.EVQLQESGPEVK.K 2 3.701 0.150 G variable region (VH) mRNA, partial cds. Homo sapiens sciellin (SCEL) mRNA, IPI:IPI00021973.1 GP:AF045941_1 complete cds; epidermal cornified K.DGYQENIS.G 1 2.015 0.132 A (95%) envelope protein precursor. Homo sapiens clone csneg1-5 immunoglobulin lambda light chain VJ GP:AF047213_1 I.NDQRPSGVPDR.F 2 2.830 0.153 G, O region, (IGL) mRNA, partial cds; VJ region. Homo sapiens clone DS2-b5 immunoglobulin lambda light chain VJ GP:AF047216_1 K.LMIYDVSNRPSGVSNR.F 2 2.337 0.129 G, O region, (IGL) mRNA, partial cds; VJ region. L.MIYDVSNRPSGVSNR.F 2 2.622 0.164 Homo sapiens clone csrf3-b1 immunoglobulin lambda light chain VJ GP:AF047230_1 K.PGQAPVLVIYK.D 1 3.412 0.326 G, O region, (IGL) mRNA, partial cds; VJ region. 2 3.234 0.327 K.PGQAPVLVIYKDT.E 2 3.287 0.310 K.QYAYWYQQKPGQAPVLVIYK.D 2 4.379 0.483 Homo sapiens clone bsmrf3-5 immunoglobulin lambda light chain VJ IPI:IPI00178482.1 GP:AF047231_1 K.DSERPSGIPER.L 1 2.009 0.112 G region, (IGL) mRNA, partial cds; VJ (92%) region. T.QYTYWYQQK.P 1 2.550 0.256 Supplementary Table 1 40 Homo sapiens clone ds3-b4 immunoglobulin lambda light chain VJ IPI:IPI00186348.1 GP:AF047233_1 K.KYAYWYQQK.S 1 2.934 0.172 G, O region, (IGL) mRNA, partial cds; VJ (98%) region. K.SGQAPVLVIYEDSK.R 2 3.469 0.419 Homo sapiens clone dp3-6 immunoglobulin lambda light chain VJ IPI:IPI00186348.1 GP:AF047234_1 K.KYAYWYKQK.S 2 3.262 0.327 G region, (IGL) mRNA, partial cds; VJ (95%) region. K.YAYWYKQK.S 1 2.503 0.094 Homo sapiens clone bsmrf3-7 immunoglobulin lambda light chain VJ GP:AF047236_1 D.NVHWYQQK.P 1 2.869 0.289 G, O region, (IGL) mRNA, partial cds; VJ region. 2 2.562 0.251 Homo sapiens clone cprf3-2 immunoglobulin lambda light chain VJ GP:AF047241_1 R.FSGSNSGDTATLTISR.V 1 2.162 0.103 G, O, P region, (IGL) mRNA, partial cds; VJ region. 2 5.084 0.336 Homo sapiens clone cprf3-4 immunoglobulin lambda light chain VJ GP:AF047242_1 K.YVHWYQQK.P 1 2.663 0.100 G region, (IGL) mRNA, partial cds; VJ region. Homo sapiens clone bsmrf3-b1 immunoglobulin lambda light chain VJ IPI:IPI00017248.1 GP:AF047246_1 R.DSSGNHYVFGTGTK.V 2 3.674 0.411 G region, (IGL) mRNA, partial cds; VJ (95%) region. Homo sapiens clone esmrf3-b2 immunoglobulin lambda light chain VJ IPI:IPI00017248.1 GP:AF047247_1 R.DSSGNHLVFGGGTK.L 2 4.289 0.341 G region, (IGL) mRNA, partial cds; VJ (93%) region. Homo sapiens clone ESMRF6-2 immunoglobulin lambda light chain VJ GP:AF047250_1 P.DRFSGSIDSSSNSASLTISGLK.T 2 2.282 0.152 A, G, O region, (IGL) mRNA, partial cds; VJ region. R.PGSAPTTVIYEDNQR.P 2 4.468 0.477 R.PGSAPTTVIYEDNQRPSGVPDR.F 2 2.814 0.112 Homo sapiens clone ESMRF6-3 immunoglobulin lambda light chain VJ GP:AF047251_1 G.SSGSIASNYVQWYQQR.P 2 3.131 0.311 G region, (IGL) mRNA, partial cds; VJ region. Homo sapiens clone H6 anti-HER3 GP:AF048774_1 -.QVQLVQSGGGLVQHGGSLR.L 2 2.959 0.252 G, O scFv mRNA, partial cds. S.DIQMTQSPSTLSASI.G 2 4.055 0.223 S.DIQMTQSPSTLSASIGDR.V 2 4.950 0.463 Homo sapiens clone 12B5 anti-Mpl GP:AF048775_1 E.YYADSVQGR.F 1 1.835 0.205 G scFv mRNA, partial cds. Homo sapiens clone BC6 immunoglobulin kappa light chain IPI:IPI00178190.1 GP:AF049682_1 K.SSQSLLHSDGK.T 1 2.468 0.248 G, P (IGVK-A18) mRNA, IGVK-A18b allele, (94%) partial cds; VKII family, JK4. 2 2.951 0.190 Homo sapiens immunoglobulin G GP:AF051099_1 kappa chain mRNA, partial cds; IgG S.ISSNYYLAWFQQKPGQAPR.L 2 2.647 0.101 G against hepatitis B surface antigen. Homo sapiens latent transforming GP:AF051344_1 growth factor-beta binding protein 4S C.ENHLACPGQECVNSPGSFQCRACP.S 2 4.488 0.123 G, O, P mRNA, complete cds; LTBP-4S. R.SPPPCTYGRCENTEGSFQCVCPM.G 2 2.675 0.133 Homo sapiens supervillin mRNA, complete cds; previously known as IPI:IPI00184247.1 GP:AF051850_1 E.KVDERAKLSVAAKRLLFR.E 2 2.565 0.173 G p205; membrane-associated F-actin (99%) binding protein. Trypanosoma cruzi putative malate dehydrogenase mRNA, nuclear gene encoding mitochondrial protein, complete cds; similar to malate GP:AF051893_1 K.LLGVSLLDGLRATRFINNARHPL.V 2 2.858 0.081 G, P dehydrogenase of Escherichia coli and Sacchromyces cerevisae; similar to Homo sapiens malate dehydrogenase precursor. L.SMAEAGAR.F 1 2.023 0.120 Homo sapiens lymphoma 2 IgG heavy GP:AF052380_1 K.GTTVSVSSASTK.- 1 2.111 0.304 G, O chain variable region mRNA, partial Supplementary Table 1 41 cds. 2 2.941 0.419 Homo sapiens lymphoma 5 IgM heavy GP:AF052383_1 chain variable region mRNA, partial K.NTLDLQMNSLR.A 2 3.413 0.191 P cds; also positive for IgD isotype. Homo sapiens lymphoma 7 IgA heavy GP:AF052386_1 chain variable region mRNA, partial L.VVVSSASPTSPK.V 1 1.836 0.267 A cds. Homo sapiens monoclonal antibody IPI:IPI00161229.1 GP:AF052530_1 MAX1 immunoglobulin light chain R.ASQGISNYLAWFQQKPGK.A 2 3.688 0.249 G (98%) variable region mRNA, partial cds. S.NYLAWFQQK.P 2 2.786 0.181 Homo sapiens monoclonal antibody IPI:IPI00161229.1 GP:AF052536_1 HW1 immunoglobulin light chain -.GIQMTQSPSSLSA.S 2 2.939 0.310 G, O (97%) variable region mRNA, partial cds. -.GIQMTQSPSSLSASVGDR.V 2 4.698 0.518 Homo sapiens monoclonal antibody GP:AF052538_1 EF16 immunoglobulin light chain S.LSAGVFGGGTK.L 1 2.625 0.208 G variable region mRNA, partial cds. Homo sapiens anti-HLA-A2/anti-HLA- A28 immunoglobulin kappa light chain IPI:IPI00053682.1 GP:AF052618_1 R.ASQSISTYLNWYQQK.P 1 2.329 0.162 G variable region (IG kappa) mRNA, (92%) partial cds. 2 3.114 0.123 R.ASQSISTYLNWYQQKPGK.A 2 3.597 0.162 S.TYLNWYQQK.P 2 2.560 0.189 Homo sapiens clone csneg8-1 immunoglobulin light chain variable GP:AF052762_1 Y.TIAWHQQQPEK.G 2 3.327 0.240 G region (HUMLV801) mRNA, partial cds; VJ region; VLVIII. Homo sapiens clone BSMRF8-B3 immunoglobulin light chain variable GP:AF052777_1 Y.SSYAIAWHQQQPEK.G 2 3.180 0.430 G region (HUMLV801) mRNA, partial cds; VJ region; VLVIII. Homo sapiens clone CPNEG9-3 immunoglobulin light chain variable IPI:IPI00152189.1 GP:AF052790_1 N.NFVYVFGTGTK.V 1 1.970 0.137 G region (HUMLV901) mRNA, partial (94%) cds; VJ region; VLIX. Homo sapiens clone DS3-B3 immunoglobulin light chain variable GP:AF052806_1 N.SGSTATLTISR.V 2 2.586 0.306 G region (HUMLV318) mRNA, partial cds; VJ region; VLIII. Homo sapiens clone CSNEG3-1 immunoglobulin light chain variable IPI:IPI00166489.1 GP:AF052809_1 A.PVLVVYDDSDRPSGIPER.F 2 4.417 0.457 G, O, P region (HUMLV318) mRNA, partial (92%) cds; VJ region; VLIII. F.SGSNSGNTATLTLSR.V 2 2.963 0.299 K.PGQAPVLVVYDDSDR.P 2 3.105 0.423 K.PGQAPVLVVYDDSDRPSGIPER.F 2 4.235 0.466 3 4.494 0.399 K.SVHWYQQKPGQAPVLVVYDDSDRPS 3 4.767 0.411 GIPER.F N.SGNTATLTLSR.V 2 2.337 0.298 Q.APVLVVYDDSDRPSGIPER.F 2 3.033 0.266 R.FSGSNSGNTATLTLSR.V 1 2.182 0.185 2 4.759 0.380 S.SSDHWVFGGGTK.R 1 2.979 0.108 Homo sapiens clone CSNEG3-B3 immunoglobulin light chain variable GP:AF052813_1 K.PGQAPVVVIYGKNNRPSGIPDR.F 3 3.693 0.218 G region (HUMLV418) mRNA, partial cds; VJ region; VLIV. N.YYASWYQQKPGQAPVV.V 2 2.560 0.131 Homo sapiens clone DS3-T1 immunoglobulin light chain variable GP:AF052814_1 G.KDNRPSGVPDR.F 2 2.665 0.155 G, O region (HUMLV418) mRNA, partial cds; VJ region; VLIV. V.LVIYGKDNRPSGVPDR.F 2 2.470 0.116 Homo sapiens endobrevin mRNA, GP:AF053233_1 complete cds; synaptobrevin; VAMP- N.VKMIVLICVIVFIIIL.F 1 2.339 0.119 A like protein. Homo sapiens chromosome 7q22 GP:AF053356_12 V.RRNQLSTLPEELGDLPLVRLDFSCN.R 2 2.697 0.103 A sequence, complete sequence; GP:AF054177_1 Homo sapiens chromodomain- R.DSPTLLPAGGSNWLAQRFHCQNG.C 2 2.628 0.175 P IPI:IPI00003589.1 Supplementary Table 1 42 helicase-DNA-binding protein mRNA, (94%) complete cds. Homo sapiens HIC protein isoform p40 and HIC protein isoform p32 mRNAs, complete cds; regulated at GP:AF054589_1 R.GVRAATAAAVAATAASGLSRREA.G 2 2.507 0.158 P the translational level; contains I-mfa domain; untilizes unique GTG start codon. Homo sapiens clone APJL1 lambda 1 GP:AF054637_1 immunoglobulin light chain variable R.VTVLSQPK.A 1 1.851 0.161 G region mRNA, partial cds. Homo sapiens clone ERFL1 lambda 1 GP:AF054639_1 immunoglobulin light chain variable K.LLIYSNDQR.P 2 2.635 0.107 G, O region mRNA, partial cds. L.LIYSNDQRPSGVPDR.F 2 2.802 0.095 Homo sapiens clone RCJL1 lambda 1 GP:AF054640_1 immunoglobulin light chain variable K.LLIYTNDQRPSGVPDR.I 2 2.537 0.188 G region mRNA, partial cds. Homo sapiens clone HPOL3 lambda 1 GP:AF054646_1 immunoglobulin light chain variable K.PGQSPVLVIYEDTKRPSGIPER.F 3 3.616 0.238 G region mRNA, partial cds. Homo sapiens clone RWJL3 lambda 1 GP:AF054647_1 immunoglobulin light chain variable N.YYSSWYQQK.P 1 2.463 0.085 G region mRNA, partial cds. Homo sapiens clone LMNL6 lambda 1 GP:AF054651_1 immunoglobulin light chain variable N.NLVFGGGTK.L 1 1.938 0.367 G region mRNA, partial cds. Homo sapiens clone LTFL6 lambda 1 IPI:IPI00064088.1 GP:AF054652_1 immunoglobulin light chain variable -.DFMLTQPHSVSESPGK.T 2 4.316 0.482 G, P (92%) region mRNA, partial cds. R.PGSAPTTVIYEDDQ.R 2 3.989 0.390 R.PGSAPTTVIYEDDQR.P 2 4.620 0.424 R.PGSAPTTVIYEDDQRPSGVPDR.F 2 3.626 0.107 3 4.388 0.329 Homo sapiens clone RHDL6 lambda 1 GP:AF054653_1 immunoglobulin light chain variable D.SQRPSGVPDR.F 2 2.327 0.208 G, O region mRNA, partial cds. E.DSQRPSGVPDR.F 2 2.937 0.172 Homo sapiens clone TOFL6 lambda 1 GP:AF054654_1 immunoglobulin light chain variable K.LTVLRQPK.A 2 2.708 0.105 P region mRNA, partial cds. Homo sapiens clone AAJK1 kappa 1 GP:AF054656_1 immunoglobulin light chain variable -.DIVMTQSPSSLSASVGDR.V 2 4.170 0.193 O, P region mRNA, partial cds. Homo sapiens clone ANOK1 kappa 1 IPI:IPI00161229.1 GP:AF054657_1 immunoglobulin light chain variable R.ASQDISNYLAWFQQK.P 2 3.258 0.266 G (92%) region mRNA, partial cds. Homo sapiens clone ILSK1 kappa 1 IPI:IPI00161229.1 GP:AF054659_1 immunoglobulin light chain variable K.SLIYAASSLQSGVPSK.F 1 2.481 0.280 G (94%) region mRNA, partial cds. Homo sapiens clone JCOK1 kappa 1 GP:AF054662_1 immunoglobulin light chain variable Q.ASQDISNYLNWYQQK.P 2 3.453 0.297 G region mRNA, partial cds. Homo sapiens clone 24719 protein 4.1-G mRNA, partial cds; similar to GP:AF054999_1 Homo sapiens protein 4.1-G encoded V.KTEMVTISDASQRTEIS.T 2 3.523 0.094 G, P by GenBank Accession Number AF027299. Homo sapiens alpha-tectorin (TECTA) IPI:IPI00023051.1 GP:AF055136_1 L.PFFSVEAKNE.H 1 2.385 0.201 G, P gene, exon 23 and complete cds. (99%) T.LNKCYATPTRDSNDKLRY.F 2 2.595 0.114 Homo sapiens ZNF258 (ZNF258) IPI:IPI00026697.1 GP:AF055470_1 E.QSQQVALTHTVVKLK.C 1 2.092 0.110 G mRNA, complete cds. (91%) Homo sapiens Usher syndrome type IIa protein (USH2A) mRNA, complete IPI:IPI00175999.1 GP:AF055580_1 R.QNNSFLCLPCNCDKTGTI.N 1 2.015 0.083 G cds; putative extracellular matrix (99%) component or cell adhesion molecule. Homo sapiens clone ASPBLL1 GP:AF058057_1 immunoglobulin lambda light chain VJ -.SYVLTQPPSVSVAPGQTAR.I 2 4.050 0.241 A, G, O, P region mRNA, partial cds. Q.PPSVSVAPGQTAR.I 1 2.550 0.321 2 3.188 0.319 R.FSGSNSGNTASLTISR.V 2 3.153 0.273 S.YVLTQPPSVSVAPGQ.T 2 4.216 0.351
Supplementary Table 1 43 S.YVLTQPPSVSVAPGQTAR.I 1 2.635 0.190 2 5.166 0.258 Y.VLTQPPSVSVAPGQTAR.I 2 3.577 0.376 Homo sapiens clone ASPBLL23 IPI:IPI00166489.1 GP:AF058063_1 immunoglobulin lambda light chain VJ -.SYVLTQPPSVSVAPGKTAR.I 2 3.808 0.203 G, O, P (94%) region mRNA, partial cds. Q.PPSVSVAPGKTAR.I 1 2.303 0.281 S.YVLTQPPSVSVAPGK.T 1 2.446 0.225 2 4.561 0.438 S.YVLTQPPSVSVAPGKTAR.I 1 2.600 0.258 2 4.947 0.226 Y.VLTQPPSVSVAPGKTAR.I 2 3.321 0.477 Homo sapiens clone ASPBLL3 GP:AF058064_1 immunoglobulin lambda light chain VJ K.PGQAPVLVVYDDSAR.P 2 4.801 0.418 G region mRNA, partial cds. Homo sapiens clone ASPBLL39 GP:AF058068_1 immunoglobulin lambda light chain VJ K.TVHWYQQK.L 1 2.671 0.208 G region mRNA, partial cds. Homo sapiens clone ASPBLL48 GP:AF058071_1 immunoglobulin lambda light chain VJ K.PGQAPVLVIFK.D 2 3.244 0.295 G region mRNA, partial cds. Homo sapiens clone ASPBLL53 GP:AF058074_1 immunoglobulin lambda light chain VJ -.SDELTQPPSVSVSPGQTAR.I 2 4.305 0.384 G, O, P region mRNA, partial cds. Homo sapiens clone ASPBLL60 GP:AF058077_1 immunoglobulin lambda light chain VJ -.SHELTQPPSVSVSPGQTAR.I 2 4.993 0.509 G, P region mRNA, partial cds. 3 4.260 0.342 Homo sapiens GTP-specific succinyl- IPI:IPI00096066.1 GP:AF058954_1 CoA synthetase beta subunit (SCS) I.ACFVNGAGLAMATCDIIFLNGGK.P 2 2.340 0.204 G, P (99%) mRNA, partial cds. K.EIVLKAQILAGGRGK.G 2 2.515 0.111 Homo sapiens protein GP:AF059198_1 kinase/endoribonulcease (IRE1) K.LTPTLYVGK.Y 1 2.006 0.222 P mRNA, complete cds; Ire1p. Homo sapiens anti HIV-1/gp41 GP:AF059200_1 immunoglobulin light chain variable K.NYLAWYQQR.P 1 2.620 0.265 G region mRNA, partial cds. 2 3.314 0.225 Homo sapiens clone ASSynL182 immunoglobulin lambda light chain GP:AF060121_1 L.GVHWYQQR.P 2 2.385 0.176 G, O, P variable region mRNA, partial cds; Vlambda-Jlambda. R.FSGSNSGNTATLTITR.V 2 4.762 0.471 Homo sapiens clone ASSynL186 immunoglobulin lambda light chain GP:AF060123_1 D.DTDRPSGIPER.F 2 2.582 0.235 G, O, P variable region mRNA, partial cds; Vlambda-Jlambda. K.PGQAPVLVVYDDTDRPSGIPER.F 2 3.253 0.278 3 4.082 0.356 Q.APVLVVYDDTDRPSGIPER.F 2 4.105 0.193 R.FSGSNSGNTATLTINR.V 2 4.416 0.554 S.YVVTQPPSVSVAPGK.T 2 2.734 0.166 S.YVVTQPPSVSVAPGKTAR.I 2 4.495 0.437 Homo sapiens clone ASSynL189 immunoglobulin lambda light chain GP:AF060125_1 G.VHWYQKK.P 1 1.989 0.205 G, P variable region mRNA, partial cds; Vlambda-Jlambda. K.PGQAPVLVIYCDSDRPSGIPER.F 3 4.627 0.423 S.DHVVFGGGTK.L 1 2.612 0.191 Homo sapiens clone ASSynL201 immunoglobulin lambda light chain GP:AF060129_1 R.WFQQKPGQAPVLVIYK.D 2 4.273 0.402 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone ASSynL204 immunoglobulin lambda light chain GP:AF060131_1 M.PGQAPVLVIYTDSERPSGIPER.F 3 3.998 0.398 G, O variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone ASSynL210 immunoglobulin lambda light chain GP:AF060133_1 S.FDLTQPPSVSVSPGQTAR.I 1 1.852 0.108 G, O variable region mRNA, partial cds; Vlambda-Jlambda.
Supplementary Table 1 44 2 3.250 0.153 Homo sapiens clone ASSynL215 immunoglobulin lambda light chain GP:AF060136_1 K.PGQAPVLLIYK.D 1 3.197 0.142 G variable region mRNA, partial cds; Vlambda-Jlambda. 2 3.931 0.202 Homo sapiens clone ASSynL216 immunoglobulin lambda light chain GP:AF060137_1 K.QYVYWYQKK.P 1 3.273 0.228 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone ASSynL220 immunoglobulin lambda light chain GP:AF060139_1 R.FSGSNSGNTATLTIR.R 2 4.119 0.373 O variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone ASSynL221 immunoglobulin lambda light chain IPI:IPI00166489.1 GP:AF060140_1 S.YVLTQPPSESVAPGK.T 2 3.291 0.247 G, O variable region mRNA, partial cds; (91%) Vlambda-Jlambda. S.YVLTQPPSESVAPGKTAR.I 2 4.001 0.414 Homo sapiens clone ASSynL234 immunoglobulin lambda light chain GP:AF060145_1 R.FSGSKSGNTATLTISR.V 2 2.795 0.287 O variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone ASSynL236 immunoglobulin lambda light chain GP:AF060147_1 K.GVHWYQQK.P 1 2.650 0.238 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens LIM protein mRNA, IPI:IPI00185339.1 GP:AF061258_1 G.KAAQANVRIGDVVL.S 1 2.123 0.137 G complete cds. (99%) P.VPITSPAVSKVTSTNNMAYNKAPR.P 2 2.542 0.155 Homo sapiens G protein-coupled receptor LGR5 (LGR5) mRNA, complete cds; leucine-rich repeat IPI:IPI00021131.1 GP:AF061444_1 containing G protein-coupled receptor; P.TEALQNLRSLQSLRLDANHI.S 2 2.644 0.123 O (91%) similar to glycoprotein hormone receptors; similar to FSH receptor, LH receptor and TSH receptor. Homo sapiens protocadherin (PCDH8) mRNA, complete cds; similar to Rattus GP:AF061573_1 norvegicus arcadlin encoded by A.QMSTFCKSTSLPRDPL.R 2 2.553 0.253 A, P GenBank Accession Number AB026154; arcadlin isoform. S.LLRVREGDGQLTVGDAGLDRER.L 2 2.265 0.106 Homo sapiens kinase deficient protein IPI:IPI00176956.1 GP:AF061944_1 Y.VCEGDHKTMAKAIKDRVS.L 2 3.260 0.222 G, O KDP mRNA, partial cds. (95%) Homo sapiens clone 21u-20 IPI:IPI00161117.1 GP:AF062106_1 immunoglobulin heavy chain variable R.VTISEDTSK.N 1 1.974 0.242 G (94%) region (IGH) mRNA, partial cds. Homo sapiens clone 45u-6 GP:AF062135_1 immunoglobulin heavy chain variable L.IYWDDDR.R 1 2.104 0.119 G region (IGH) mRNA, partial cds. Homo sapiens clone 45u-8 IPI:IPI00007861.1 GP:AF062137_1 immunoglobulin heavy chain variable K.WYNDYAASVK.S 1 2.390 0.209 G (92%) region (IGH) mRNA, partial cds. Homo sapiens clone 45u-18 GP:AF062144_1 immunoglobulin heavy chain variable Y.IYDSGSTNYNPSLK.S 2 4.581 0.293 G region (IGH) mRNA, partial cds. Homo sapiens clone 45u-28 GP:AF062153_1 immunoglobulin heavy chain variable K.FYSTSLK.T 1 1.973 0.120 G, P region (IGH) mRNA, partial cds. K.NQVVLTMTNMDPVDTATYYCARIWGR 3 4.794 0.132 YYFDY.W L.IDWDDDKFYSTSLK.T 2 2.719 0.300 Homo sapiens clone 45u-32 GP:AF062157_1 immunoglobulin heavy chain variable -.EVQLVQSGAEAK.K 1 2.562 0.159 G region (IGH) mRNA, partial cds. 2 2.671 0.180 Homo sapiens clone 45u-43 GP:AF062168_1 immunoglobulin heavy chain variable C.EMQLVESGGGLVQPGGSLR.L 2 3.895 0.436 A, G, P region (IGH) mRNA, partial cds. Homo sapiens clone 45u-47 GP:AF062172_1 immunoglobulin heavy chain variable C.EVQLVESGGGLLQPGGSLR.L 2 5.212 0.389 G, O, P region (IGH) mRNA, partial cds. 3 3.907 0.191 Q.LVESGGGLLQPGGSLR.L 2 3.008 0.211 Supplementary Table 1 45 Homo sapiens clone 23u-2 GP:AF062213_1 immunoglobulin heavy chain variable -.QVQLQLSGPGLVK.P 1 2.506 0.156 G region (IGH) mRNA, partial cds. Homo sapiens clone 23u-24 GP:AF062224_1 immunoglobulin heavy chain variable -.QVRLVQSGAEVK.R 1 2.400 0.225 G, O, P region (IGH) mRNA, partial cds. 2 3.781 0.276 Homo sapiens clone 23u-40 GP:AF062236_1 immunoglobulin heavy chain variable K.NTLYLQMSSLR.A 2 3.679 0.345 G, P region (IGH) mRNA, partial cds. Homo sapiens clone 23u-42 GP:AF062238_1 immunoglobulin heavy chain variable R.NTVYLQMDSLR.A 1 2.018 0.097 G region (IGH) mRNA, partial cds. 2 3.718 0.278 Homo sapiens clone 23u-45 IPI:IPI00182107.1 GP:AF062241_1 immunoglobulin heavy chain variable -.EVQLVESGGGLVQSGGSLR.L 2 3.435 0.269 O (94%) region (IGH) mRNA, partial cds. Homo sapiens clone Xu-1 IPI:IPI00161060.3 GP:AF062248_1 immunoglobulin heavy chain variable C.EEQPVESGGGLVQPGGSLR.L 2 2.766 0.206 G (93%) region (IGH) mRNA, partial cds. E.QPVESGGGLVQPGGSLR.L 2 2.967 0.350 Homo sapiens clone Xu-8 GP:AF062253_1 immunoglobulin heavy chain variable Q.LVESGGGLVQTGGSLR.L 2 4.476 0.358 O region (IGH) mRNA, partial cds. Homo sapiens clone Xu-14 IPI:IPI00161060.3 GP:AF062259_1 immunoglobulin heavy chain variable R.AEDTAVYYCARDY.Y 2 3.600 0.155 G, O (97%) region (IGH) mRNA, partial cds. R.INSDGSSTRYADSVK.G 2 3.360 0.098 Homo sapiens clone Xu-52 GP:AF062280_1 immunoglobulin heavy chain variable C.EVQLLESGGGLLQPGGSLR.L 2 2.681 0.185 G region (IGH) mRNA, partial cds. Q.LLESGGGLLQPGGSLR.L 2 3.750 0.267 Homo sapiens clone 48sc-95 GP:AF062305_1 immunoglobulin heavy chain variable Q.LVESGGGLVKPGR.S 2 3.893 0.264 G, O region (IGH) mRNA, partial cds. Homo sapiens lens epithelium-derived GP:AF063020_1 growth factor mRNA, complete cds; P.YSENKEK.Y 1 2.286 0.137 P LEDGF. Homo sapiens coiled-coil related protein DEEPEST (DEEPEST) mRNA, GP:AF063308_1 E.QPLDPIPQISSTPKTSEEAV.D 2 2.509 0.127 A, G, P complete cds; associated with mitotic spindle apparatus. K.EVRDLKETLEFADQE.N 1 2.223 0.114 K.NEKELQEVIQQN.E 1 2.439 0.085 Homo sapiens brain my037 protein GP:AF063595_1 L.QLICFLIPDPQ.C 1 2.690 0.097 G mRNA, complete cds. Homo sapiens brain my040 protein GP:AF063598_1 R.EGHPRTPALPGRASP.R 1 2.454 0.159 P mRNA, complete cds. Homo sapiens clone BCPBLL1 immunoglobulin lambda light chain IPI:IPI00186348.1 GP:AF063694_1 -.SYDLTQPPSVSVSPGQTAR.I 2 3.841 0.364 G, O, P variable region mRNA, partial cds; (94%) Vlambda-Jlambda. K.SGQAPVLVIYDDTK.R 2 2.676 0.173 Homo sapiens clone BCPBLL14 immunoglobulin lambda light chain GP:AF063697_1 K.SDSDKQQGSGVPSR.F 2 2.903 0.266 G, O variable region mRNA, partial cds; Vlambda-Jlambda. R.YKSDSDKQQGSGVPSR.F 2 4.001 0.432 Homo sapiens clone BCPBLL2 immunoglobulin lambda light chain GP:AF063701_1 K.PGQSPVLVIYEDSK.R 2 2.872 0.207 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone BCPBLL27 immunoglobulin lambda light chain GP:AF063704_1 -.SYELTQSPSVSVSPGQTAR.I 2 5.001 0.509 G, O, P variable region mRNA, partial cds; Vlambda-Jlambda. S.YELTQSPSVSVSPGQTAR.I 2 3.719 0.449 Y.ELTQSPSVSVSPGQTAR.I 2 2.275 0.186 Homo sapiens clone BCPBLL3 immunoglobulin lambda light chain GP:AF063706_1 K.PGQAPVLVVYDDNDRPSGIPER.F 2 3.367 0.323 G variable region mRNA, partial cds; Vlambda-Jlambda. Q.APVLVVYDDNDRPSGIPER.F 2 4.321 0.260 GP:AF063707_1 Homo sapiens clone BCPBLL31 -.SYELTQAPSVSVSPGQTAR.I 2 4.381 0.443 G, O, P IPI:IPI00186348.1
Supplementary Table 1 46 immunoglobulin lambda light chain (91%) variable region mRNA, partial cds; Vlambda-Jlambda. K.SGQAPVLVIYEDSR.R 2 4.193 0.337 K.SGQAPVLVIYEDSRRPSGIPER.F 3 3.644 0.198 S.YELTQAPSVSVSPGQTAR.I 2 2.803 0.234 Homo sapiens clone BCSynL1 immunoglobulin lambda light chain GP:AF063714_1 R.PGSAPTAVIYEDDR.R 2 2.943 0.183 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone BCSynL18 immunoglobulin lambda light chain GP:AF063717_1 K.PGQAPILLIYK.D 2 3.508 0.162 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone BCSynL36 immunoglobulin lambda light chain GP:AF063723_1 D.DDDRPSGIPER.F 2 2.844 0.138 G, O, P variable region mRNA, partial cds; Vlambda-Jlambda. K.PGQAPVLVVYDDDDRPSGIPER.F 3 4.746 0.415 R.FSGSNSGHTATLTISR.V 2 4.116 0.456 S.YVLTQSPAVSVAPGQTAR.I 2 3.722 0.361 Homo sapiens clone BCSynL4 immunoglobulin lambda light chain GP:AF063726_1 K.PGQAPVLVIYYNSD.R 2 2.909 0.127 A, G, O, P variable region mRNA, partial cds; Vlambda-Jlambda. S.YVLTQPPSVSAAPGTTATI.T 2 3.415 0.205 T.QPPSVSAAPGTTATITCGGNNIETK.S 2 2.475 0.168 Y.NSDRPSGIPER.F 2 2.600 0.231 Homo sapiens clone ITPBLL66 immunoglobulin lambda light chain GP:AF063749_1 N.SDNTATLTISR.V 2 2.324 0.326 G, O variable region mRNA, partial cds; Vlambda-Jlambda. R.FSGSNSDNTATLTISR.V 2 4.464 0.477 Y.SVHWYQQR.A 1 2.442 0.315 2 2.724 0.186 Homo sapiens clone LBPBLL3 immunoglobulin lambda light chain GP:AF063771_1 -.SYVLTQPPSLSVAPGQTAR.I 2 2.529 0.162 G, O variable region mRNA, partial cds; Vlambda-Jlambda. S.YVLTQPPSLSVAPGQTAR.I 2 3.527 0.409 W.DSSGDHVVFGGGTK.L 2 3.138 0.291 Homo sapiens clone LBPBLL4H immunoglobulin lambda light chain GP:AF063779_1 R.FSGSNSGNTATLTIVGT.Q 2 3.772 0.443 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone LBPBLL5 immunoglobulin lambda light chain GP:AF063781_1 K.PGQAPVLVIYR.D 1 2.652 0.103 G, O variable region mRNA, partial cds; Vlambda-Jlambda. 2 2.860 0.141 K.PGQAPVLVIYRDS.Q 2 3.965 0.219 Homo sapiens KE04p mRNA, complete cds; similar to GP:AF064093_1 Caenorhabditis elegans protein H.LAVYYRGGALLTSPSGPGY.H 2 2.966 0.105 G C42C1.9 encoded by GenBank Accession Number AF043695. Homo sapiens Dhm1-like protein IPI:IPI00100151.1 GP:AF064257_1 mRNA, complete cds; similar to Mus N.GKKYAWQGVALLPFVDERRLR.A 2 2.870 0.094 A (92%) musculus Dhm1 protein. Homo sapiens clone LKPBLL68 immunoglobulin lambda light chain GP:AF064501_1 R.PGQAPVVVIYK.D 1 3.127 0.169 G variable region mRNA, partial cds; Vlambda-Jlambda. 2 3.477 0.176 Homo sapiens clone LKPBLL9 immunoglobulin lambda light chain GP:AF064513_1 K.SGQAPVLVIYK.D 1 2.785 0.315 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens low-density lipoprotein IPI:IPI00024531.1 GP:AF064548_1 receptor-related protein 5 (LRP5) I.AIDYDPLEGYVYWTDDEVRA.I 2 2.748 0.135 A, G (97%) mRNA, complete cds. L.LQNLLTCGEPP.T 2 3.586 0.115 GP:AF064879_1 Homo sapiens clone C2 R.VTISVDTSE.N 1 2.122 0.089 G Supplementary Table 1 47 immunoglobulin heavy chain alpha VDJ region mRNA, partial cds; includes IGHV4 gene. Homo sapiens hyperpolarization- activated, cyclic nucleotide-gated GP:AF065164_1 A.SPPGAPASPR.A 1 2.333 0.181 G channel 2 (HCN2) mRNA, complete cds. Mus musculus FGF binding protein 1 mRNA, complete cds; heparin and fibroblast growth factor binding; similar GP:AF065441_1 to Homo sapiens HBp17 protein A.ATQTMAIRDPECLEDPD.V 2 3.244 0.188 O encoded by sequence in GenBank Accession Number M60047; FGFBP- 1. Homo sapiens protein phosphatase-1 regulatory subunit 7 (PPP1R7) gene, K.LTMLDIASNRIKKIENISHLTELQEFWMN IPI:IPI00010628.1 GP:AF067136_1 3 4.013 0.235 A, G exon 11, complete cds and D.N (95%) alternatively spliced product. P.QYRRKVMLALPSVRQIDATFVR.F 2 2.309 0.174 Homo sapiens ganglioside expression GP:AF067171_1 factor 2 homolog mRNA, complete K.YPDRVPVIVEKAPKAR.I 1 2.017 0.114 G cds; simlar to GEF-2. Homo sapiens GP:AF068302_1 choline/ethanolaminephosphotransfer A.GTFMFYCAHWQTYVSGTLR.F 2 2.294 0.186 A, O ase (CEPT1) mRNA, complete cds. V.PSWIAPNLITIIGLSINICTT.I 2 2.862 0.135 Homo sapiens isolate AJ GP:AF068653_1 immunoglobulin heavy chain FW2-JH K.KTVYLQMN.S 1 2.004 0.093 G region gene, partial cds. N.VSTTHYADSVK.G 2 2.435 0.187 Homo sapiens clone fh22 immunoglobulin light chain variable GP:AF069039_1 T.GIWVFGGGTK.L 1 2.572 0.194 G region (V lambda 4b) gene, partial cds. Homo sapiens clone mge12 immunoglobulin light chain variable GP:AF069048_1 K.LTVXGQPK.A 1 2.129 0.238 A, G, O, P region (V lambda 4b) gene, partial cds. 2 2.521 0.134 L.TVXGQPK.A 1 1.971 0.153 Homo sapiens clone mge4 immunoglobulin light chain variable GP:AF069049_1 K.LTVVGQPK.A 1 2.117 0.146 G region (V lambda 4b) gene, partial cds. Sus scrofa matrix metalloproteinase 3 precursor (MMP-3) mRNA, partial cds; stromelysin-1; similar to Homo GP:AF069641_1 A.IRGNDVQPGYPRSIHTLGFPSTVKK.I 2 2.563 0.144 O sapiens gingival fibroblast stromelysin encoded by GenBank Accession Number X05232. Homo sapiens PCAF associated IPI:IPI00004325.1 GP:AF069736_1 factor 65 beta mRNA, complete cds; R.YLQSDNNTALCK.V 2 2.625 0.093 A (94%) PAF65-beta. Homo sapiens neutral GP:AF069740_1 sphingomyelinase mRNA, complete A.GFWFVPEVMVTIAADK.I 1 2.636 0.121 G cds. Homo sapiens HERC2 (HERC2) mRNA, complete cds; contains three RCC1 like domains, a ZZ zinc finger IPI:IPI00176908.1 GP:AF071172_1 L.TDEGLVFSWGDGDFGKLGRGGS.E 2 2.659 0.150 G, O, P and a carboxyl terminal HECT (97%) domain; partially similar to p532 protein. V.ECGSQFSVALTKSGAV.Y 2 2.425 0.100 V.HSWGSNDQCQHFDTLRVTKPEPA.A 2 3.492 0.264 Homo sapiens Key-1A6 protein IPI:IPI00004970.1 GP:AF072718_1 mRNA, complete cds; multiple N.STYSEQDPLLK.N 1 2.741 0.084 A (93%) cancer's related protein. Homo sapiens HQ0024c mRNA, complete cds; leucine zipper region at IPI:IPI00217884.1 GP:AF073836_1 C-terminus similar to mouse c-Jun Y.RQMDLQTPDSHLR.Q 2 3.117 0.174 O (94%) leucine zipper interactive, PIR Accession Number B46132. Homo sapiens protein associated with C.GRYAGGQGYNSIGHFCGGWAGNCGD IPI:IPI00004918.1 GP:AF075587_1 Myc mRNA, complete cds; PAM; 3 3.801 0.168 O GGIGGSTWYLVCDR.C (96%) nuclear; contains RCC1 repeats. K.LSQSEENISGMTSFREVLEKMLVIVVLP 3 3.704 0.108 Supplementary Table 1 48 .V Homo sapiens rheumatoid arthritis patient C265-6, immunoglobulin GP:AF076202_1 G.VWVFGGGTK.L 1 1.825 0.100 G lambda light chain variable region (V4b) mRNA, partial cds. Homo sapiens TRRAP protein (TRRAP) mRNA, complete cds; IPI:IPI00006785.1 GP:AF076974_1 similar to ATM/DNA-PK; nuclear I.AAKHILTTELRNQ.F 2 2.868 0.103 G, O, P (96%) cofactor of c-Myc and E2F oncoproteins. L.RDVLAANPNR.F 2 2.783 0.121 P.EMVGMITTIAVKVNPEREDSE.T 2 3.413 0.112 Q.QGLAKCYSVA.F 2 2.458 0.179 Y.FLLLRALFRSIGGGSH.D 2 2.563 0.163 Homo sapiens clone BF3N3g1D12 GP:AF077422_1 immunoglobulin heavy chain variable M.GLVDPEDGETIYAEK.F 2 3.824 0.334 G region gene, partial cds; VH(D)JH. Homo sapiens clone BF3N2g3D10 IPI:IPI00180166.1 GP:AF077459_1 immunoglobulin heavy chain variable K.SETDGGTTDYAAPVK.G 2 3.653 0.373 G, P (91%) region gene, partial cds; VH(D)JH. R.IKSETDGGTTDYAAPVK.G 2 3.656 0.367 Mus musculus hybridoma M291 anti- GP:AF078547_1 human CD3 immunoglobulin heavy R.HWIFLLLLSVTAGVHSQVQLQ.Q 2 2.956 0.219 G chain precursor, mRNA, partial cds. Homo sapiens voltage-gated potassium channel eagB (EAG) IPI:IPI00182296.1 GP:AF078742_1 A.PLILPPDHPVR.R 2 2.689 0.124 G, O mRNA, complete cds; heagB; K+ (94%) channel. V.LQLGSDILPQYKQEAPKTPP.H 2 2.483 0.224 Homo sapiens clone JM4 GP:AF078940_1 immunoglobulin heavy chain variable -.EVQLVESGPEVK.K 1 3.185 0.150 G region mRNA, partial cds. 2 2.731 0.101 -.EVQLVESGPEVKKPGESLK.I 2 2.930 0.103 K.SITTAYLQWSSLK.A 1 2.160 0.341 Homo sapiens clone JM5 IPI:IPI00018563.3 GP:AF078941_1 immunoglobulin heavy chain variable K.SISTAFLQWSSLK.A 1 2.613 0.285 G (93%) region mRNA, partial cds. 2 3.630 0.317 Homo sapiens clone JM4 IPI:IPI00017248.1 GP:AF078943_1 immunoglobulin light chain variable K.PGQAPVLVIYGENS.R 2 3.011 0.272 G (94%) region mRNA, partial cds. Homo sapiens clone JM5 IPI:IPI00053682.1 GP:AF078944_1 immunoglobulin light chain variable -.DIQLTQSPSFL.S 2 3.403 0.171 G, O, P (92%) region mRNA, partial cds. -.DIQLTQSPSFLSA.S 1 2.229 0.259 2 3.931 0.290 -.DIQLTQSPSFLSAS.V 2 3.861 0.302 -.DIQLTQSPSFLSASVGDR.V 1 3.228 0.301 2 5.132 0.496 Homo sapiens clone MH11 GP:AF078950_1 immunoglobulin light chain variable -.TIQMTQSPSTLSA.S 2 2.482 0.192 G region mRNA, partial cds. K.APNLLIYK.A 1 2.204 0.084 Mus musculus anti-human chorionic gonadotropin monoclonal antibody GP:AF081075_1 S.SYLHWYQQK.T 1 2.355 0.213 G AB2 Ig kappa light chain variable region mRNA, partial cds. Mus musculus anti-human chorionic gonadotropin monoclonal antibody GP:AF081077_1 N.TYLHWYLQK.P 1 2.507 0.199 G AB4 Ig kappa light chain variable region mRNA, partial cds. 2 2.600 0.344 R.FSGSGSGTHFTLK.I 1 2.182 0.149 2 3.851 0.422 W.YLQKPGQSPK.L 2 2.572 0.205 Homo sapiens serine phosphatase FCP1a (FCP1) mRNA, complete cds; component of RNA polymerase II GP:AF081287_1 holoenzyme; Mg-dependent; okadaic T.RLVLSPDAPDR.A 1 2.037 0.117 P acid-resistant; activity stimulated by TFIIF and inhibited by TFIIB; specific for the C-terminal heptapeptide repeat Supplementary Table 1 49 dom Homo sapiens tumor necrosis factor receptor-associated factor 4A IPI:IPI00017037.3 GP:AF082185_1 (TRAF4) mRNA, complete cds; Q.GHLNTCSFNVIPCPNRCPMK.L 2 2.545 0.105 G (95%) putative TRAF4 splice-variant; TRAF4A. Homo sapiens clone 5.5 anti- pneumococcal/anti-dsDNA Ig L-chain GP:AF082203_1 K.LLIYAASSLESGVPSR.F 2 2.634 0.178 G, O Fab fragment (Vk1-Jk2) mRNA, partial cds; Vk1-Jk2. L.LIYAASSLESGVPSR.F 2 4.095 0.132 Homo sapiens clone 1.6 anti- pneumococcal/anti-dsDNA Ig L-chain IPI:IPI00053682.1 GP:AF082204_1 S.TPLTFGGGTK.V 1 2.264 0.421 G Fab fragment (Vk1-Jk4) mRNA, partial (93%) cds; Vk1-Jk4. Homo sapiens clone 8.55 anti- pneumococcal/anti-dsDNA Ig L-chain GP:AF082207_1 L.HSYPRTFGPGTK.V 1 1.901 0.122 G, P Fab fragment (Vk1-Jk3) mRNA, partial cds; Vk1-Jk3. R.ASQDISSYLAWYQQEPGKAPR.L 2 2.333 0.125 S.YLAWYQQEPGKAPR.L 2 4.430 0.238 Y.LAWYQQEPGKAPR.L 2 3.766 1.000 Homo sapiens clone 6.29 anti- pneumococcal/anti-dsDNA Ig L-chain IPI:IPI00030205.1 GP:AF082208_1 A.SQSVSRNYLAWYQQKPGQAPR.L 2 3.349 0.166 G, O Fab fragment (Vk3-Jk1) mRNA, partial (91%) cds; Vk3-Jk1. R.LLIYDTSTR.A 2 2.521 0.145 Homo sapiens D-type cyclin- IPI:IPI00074484.1 GP:AF082569_1 interacting protein 1 (DIP1) mRNA, P.RVRVGEDQETTEEFNREMF.W 2 2.603 0.082 G (92%) complete cds; Id-related protein. Homo sapiens sirtuin type 1 (SIRT1) mRNA, complete cds; yeast silent GP:AF083106_1 A.MKYDKDEVDLLIVIGSSLKVR.P 2 3.617 0.155 O, P information regulator 2 (Sir2p) homolog. I.YARLAVDFPDLPDPQAMFDI.E 2 2.410 0.189 L.DDMTLWQIVINILSEPPKR.K 2 2.369 0.217 Homo sapiens Che-1 mRNA, GP:AF083208_1 complete cds; interacts with RNA E.EGDDAEDSQGESEEDR.A 1 1.815 0.108 G polymerase II subunit 11. Homo sapiens Rb binding protein GP:AF083249_1 K.GKGTNSSDSEELSAGESITKS.Q 2 3.334 0.125 A, G, P homolog mRNA, partial cds. Homo sapiens clone TonB02 IPI:IPI00018563.3 GP:AF085657_1 immunoglobulin heavy chain variable A.EVQLVQSAAEVK.R 1 3.040 0.279 G, O (95%) region (VH5) mRNA, partial cds. 2 3.578 0.179 Homo sapiens clone TonC17 GP:AF085664_1 immunoglobulin heavy chain variable K.SINTAYLQWSSLK.A 1 2.818 0.339 G, P region (VH5) mRNA, partial cds. 2 3.925 0.388 Homo sapiens clone TonC14 GP:AF085678_1 immunoglobulin heavy chain variable R.IDPSDSYTNYSPSLQGH.V 2 3.289 0.368 G region (VH5) mRNA, partial cds. Homo sapiens anti-HIV-1 gp41 IPI:IPI00003486.1 GP:AF086900_1 antibody 31 kappa light chain variable A.WYQQKPGEAPR.L 2 3.001 1.000 G, O (95%) region mRNA, partial cds; VL-region. R.ASQSVSSSYLAWYQQKPGEAPR.L 2 4.083 0.212 S.VSSSYLAWYQQKPGEAPR.L 2 3.052 0.256 S.YLAWYQQKPGEAPR.L 2 4.152 1.000 Homo sapiens clone 3A immunoglobulin heavy chain variable GP:AF087419_1 -.EVHLVESGGGLVTPGGSLR.L 2 4.574 0.371 G, P region gene, partial cds; closest germline counterpart V3-21. K.NSLYLQMNNLR.A 2 3.246 0.217 Homo sapiens clone 5A immunoglobulin heavy chain variable GP:AF087423_1 F.TNYYLHWVR.Q 1 1.977 0.096 G, P region gene, partial cds; closest germline counterpart V1-02. W.INPDSGGTNYAQK.F 1 2.934 0.113 2 2.792 0.301 Homo sapiens clone 7B immunoglobulin heavy chain variable GP:AF087428_1 R.GSTNYNPSLESR.V 2 3.041 0.333 G, P region gene, partial cds; closest germline counterpart V4-34.
Supplementary Table 1 50 Homo sapiens emilin precursor, G.PGVGGPSRGPLDGFSVFGGSSGSALQ GP:AF088916_1 mRNA, complete cds and 3' UTR; C1q 2 2.482 0.191 G, O A.L protein family member. R.GRLEQLGGLLANVSGELGGRLDLLEE 2 2.617 0.155 QVA.G S.EEPLTIFSGALL.Y 1 2.325 0.096 Homo sapiens IgA type multiple myeloma clone PEF-IgD3 immunoglobulin heavy chain variable GP:AF089000_1 -.QMQLQESGPGL.V 2 3.169 0.118 G, P region (VH4) mRNA, VH4-VIV-4/4.35 allele, partial cds; contains V-D junction. -.QMQLQESGPGLVK.P 2 4.171 0.276 Y.NPSLKSRVTMSLDTSKSRFSLR.L 2 2.290 0.121 Homo sapiens gamma-filamin (ABPL) IPI:IPI00165017.2 GP:AF089841_1 mRNA, complete cds; similar to actin- T.IGSTCDLNLKIPGNWFQMV.S 2 2.903 0.177 P (97%) binding protein. V.GEAATFTVDCSEAGEA.E 2 2.473 0.112 GP:AF090114_1 Homo sapiens unknown mRNA. I.AELRQEAEEAEK.K 2 2.488 0.194 A, O R.SLLNPQDTPVKISAPELLLHSPARSAM. 2 3.270 0.111 C Homo sapiens clone C8 anti-mucin1 GP:AF090354_1 light chain variable region mRNA, -.DIQMTQSPSSLPASVGDR.V 1 2.436 0.172 G, O partial cds; anti-MUC1. 2 4.284 0.360 Homo sapiens clone G8 anti-mucin1 GP:AF090357_1 light chain variable region mRNA, -.DIQMTQSPSFLSA.S 2 3.089 0.351 G, O partial cds; anti-MUC1. -.DIQMTQSPSFLSASVGDR.V 2 4.671 0.302 Homo sapiens ribosome S6 protein H.SHGKTTPTKTLQPSNPADSNNPETLFQ IPI:IPI00006251.1 GP:AF090421_1 kinase mRNA, complete cds; 2 2.637 0.164 A F.S (95%) S6PKH2. Homo sapiens anti-tetanus toxoid GP:AF092284_1 antibody gene, partial cds; heavy R.VTVSVDTSK.N 1 2.125 0.232 G chain V region; Ig VH4 JH5b. Homo sapiens putative HIV-1 infection IPI:IPI00152947.1 GP:AF094583_1 G.IADTWQVVGTVTCKCDL.E 2 3.052 0.170 O, P related protein mRNA, partial cds. (99%) Homo sapiens Fas associated factor 1 L.ERRFLASNKLQIVFDFVASKGFPWDEY GP:AF094700_1 3 3.867 0.088 O mRNA, complete cds; FAF1. K.L Homo sapiens PTH-responsive IPI:IPI00018497.1 GP:AF095770_1 osteosarcoma D1 protein (D1) mRNA, I.PKDTSQLKKHITLLCDR.L 1 2.087 0.240 A (99%) partial cds. Homo sapiens 10IHW 9082 IkBL protein (NFKBIL1) mRNA, NFKBIL1- GP:AF097421_1 A.MAAALVARGPPLEEQGALR.R 1 2.014 0.104 G +738C allele, complete cds; simlar to IkBa; contains ankyrin repeats. Homo sapiens clone 1 GP:AF097594_1 immunoglobulin kappa light chain S.WYKQKPGK.A 1 1.890 0.081 G variable region gene, partial cds. Homo sapiens clone 1 IPI:IPI00003486.1 GP:AF097608_1 immunoglobulin kappa light chain R.ASQSVSNNYLAWYQQK.P 2 4.678 0.317 G (92%) variable region gene, partial cds. S.NNYLAWYQQK.P 1 2.834 0.137 2 3.429 0.090 Homo sapiens clone 1 GP:AF097613_1 immunoglobulin kappa light chain R.RATGIPDRVSGSGSGTDFTLTISR.L 3 3.938 0.277 G, O, P variable region gene, partial cds. Homo sapiens clone 5 GP:AF097621_1 immunoglobulin kappa light chain N.YLDWYQQKPGK.A 2 3.719 1.000 G, P variable region gene, partial cds. Q.ASQDISNYLDWYQQK.P 2 3.013 0.287 Homo sapiens L-kynurenine/alpha- GP:AF097994_1 aminoadipate aminotransferase D.VKELIEEKAVK.M 1 1.839 0.111 A, O, P mRNA, complete cds. E.IYELAR.K 1 1.938 0.104 Homo sapiens clone HuF15-VH immunoglobulin heavy chain variable IPI:IPI00182107.1 GP:AF098360_1 K.YYVDSVEGR.F 2 2.878 0.341 G region mRNA, partial cds; tumor (91%) reactive antibody. Homo sapiens clone HuF86-VH immunoglobulin heavy chain variable GP:AF098362_1 -.SLQLVESGGGLVQPGGSLR.L 2 4.826 0.452 G, O, P region mRNA, partial cds; tumor reactive antibody. Homo sapiens clone HuF86-VL GP:AF098363_1 -.NIQMTQSPSSLSASVGDR.V 1 1.999 0.118 G immunoglobulin light chain variable Supplementary Table 1 51 region mRNA, partial cds; tumor reactive antibody. 2 2.608 0.318 T.YLAWYQHK.P 1 2.326 0.234 Homo sapiens clone HuF133-VH immunoglobulin heavy chain variable GP:AF098364_1 -.EVHLVESGGGLVKPGGSLR.L 1 2.562 0.372 G, P region mRNA, partial cds; tumor reactive antibody. 2 5.796 0.509 3 3.536 0.357 Homo sapiens clone HuTA50-VH immunoglobulin heavy chain variable GP:AF098366_1 -.QIQLVQSGAEVK.K 1 2.978 0.151 G, O region mRNA, partial cds; tumor reactive antibody. 2 3.658 0.153 Homo sapiens clone HuTA50-VL immunoglobulin light chain variable IPI:IPI00003486.1 GP:AF098367_1 R.FSGTGSGTDFTLTISR.L 2 2.757 0.204 G region mRNA, partial cds; tumor (91%) reactive antibody. Homo sapiens rabaptin-4 mRNA, IPI:IPI00178882.1 GP:AF098638_1 E.KLRSVVMPMEK.E 1 1.855 0.156 A, O complete cds. (93%) V.KLSQTLQVQL.E 1 2.001 0.093 Homo sapiens HodVL immunoglobulin IPI:IPI00026197.1 GP:AF099195_1 IgM light chain variable region mRNA, R.FSGSGSGTDFTLTIR.P 2 3.935 0.404 G, O (98%) partial cds. Homo sapiens clone Pt.4-2 Ig V kappa IPI:IPI00178198.1 GP:AF099646_1 -.ASQSVSSYXAWYQQK.P 2 3.237 0.082 G light chain gene, partial cds; Vg. (98%) -.ASQSVSSYXAWYQQKPGQAPR.L 2 4.473 0.086 Q.SVSSYXAWYQQK.P 1 1.888 0.284 2 2.663 0.239 S.SYXAWYQQK.P 1 2.657 0.159 S.SYXAWYQQKPGQAPR.L 2 3.415 1.000 S.YXAWYQQK.P 1 2.664 1.000 2 2.778 0.275 S.YXAWYQQKPGQAPR.L 1 3.237 1.000 2 4.254 1.000 V.SSYXAWYQQKPGQAPR.L 2 2.284 0.202 Y.XAWYQQK.P 1 2.125 0.083 Y.XAWYQQKPGQ.A 1 2.606 1.000 2 2.722 1.000 Y.XAWYQQKPGQAPR.L 2 3.453 1.000 Homo sapiens immunoglobulin GP:AF099676_1 lambda 2 light chain mRNA, partial K.SGNTASLSISGLQADDEAVYYC.S 2 2.527 0.217 P cds. Homo sapiens Sec22 homolog mRNA, IPI:IPI00063881.1 GP:AF100749_1 P.DRCTLKTGHYNIKFISSLGVSY.M 2 2.643 0.207 A complete cds. (99%) Homo sapiens T-cell receptor beta GP:AF100783_1 chain (TCR) mRNA, partial cds; F.CASKQSGTSGRHEQYFGPGTR.L 2 2.566 0.163 A antigen specific receptor. Caenorhabditis elegans cosmid C02E11, complete sequence; contains similarity to human Pm5 protein; coded for by the following C. elegans GP:AF101304_1 L.ENDKNAAVSIR.I 2 2.809 0.100 P cDNAs: yk4b11.3, yk4b11.5, yk7d11.3, yk7d11.5, yk21f6.3, yk21f6.5, yk28c8.3, yk39a8.5, yk286h3.3, yk286h3.5, yk33 Homo sapiens dachshund (DACH) mRNA, complete cds; transcription GP:AF102546_1 V.TSTGGGGGGGGSGGGGGSSGNG.G 1 2.440 0.121 P factor; Drosophila melanogaster dachshund homolog. Homo sapiens isolate donor D clone GP:AF103026_1 D1 immunoglobulin heavy chain R.SISTAYLQWSSLQ.A 1 2.656 0.202 G, P variable region mRNA, partial cds. 2 3.631 0.364 Homo sapiens isolate donor D clone GP:AF103028_1 D101 immunoglobulin heavy chain D.SFDYWGQGTLVTVSSASTK.A 2 3.455 0.498 G variable region mRNA, partial cds. Homo sapiens isolate donor D clone GP:AF103033_1 D106 immunoglobulin heavy chain R.VTMSVDQ.S 1 1.842 0.197 G variable region mRNA, partial cds. Homo sapiens isolate donor D clone GP:AF103035_1 V.SIIDASGETTYYADSVR.G 2 2.644 0.158 G, O D108 immunoglobulin heavy chain Supplementary Table 1 52 variable region mRNA, partial cds. Homo sapiens isolate donor D clone GP:AF103036_1 D109 immunoglobulin heavy chain Q.GTTVIVSSASTK.A 1 2.273 0.282 G, O variable region mRNA, partial cds. 2 3.647 0.397 V.IVSSASTK.A 1 2.107 0.124 Homo sapiens isolate donor D clone IPI:IPI00018563.3 GP:AF103038_1 D110 immunoglobulin heavy chain G.SYSDFWGQGTLVTVSSASTK.A 2 2.442 0.108 G, P (94%) variable region mRNA, partial cds. R.YSPSFQGQVTISVDK.S 2 3.493 0.369 Y.SDFWGQGTLVTVSSASTK.A 2 2.208 0.353 Homo sapiens isolate donor D clone GP:AF103051_1 D16 immunoglobulin heavy chain Q.GTLVSVSSASTK.A 1 2.478 0.251 G, O variable region mRNA, partial cds. 2 3.195 0.291 Homo sapiens isolate donor D clone GP:AF103052_1 D17 immunoglobulin heavy chain T.ITADKSTSTAYMEVSSLR.S 1 2.027 0.140 A variable region mRNA, partial cds. Homo sapiens isolate donor D clone IPI:IPI00178577.1 GP:AF103053_1 D18 immunoglobulin heavy chain P.GTTVAVSSASTK.A 1 2.091 0.335 G, O (92%) variable region mRNA, partial cds. 2 3.346 0.331 Homo sapiens isolate donor D clone GP:AF103058_1 D23 immunoglobulin heavy chain M.GGGNWLDRWGQGTLVTVSSASTK.G 2 3.846 0.110 G variable region mRNA, partial cds. Homo sapiens isolate donor D clone GP:AF103059_1 D28 immunoglobulin heavy chain G.PFDYWGQGTLVTVSSASTK.A 2 2.309 0.167 G variable region mRNA, partial cds. N.KYYGDSVK.G 1 2.166 0.323 Homo sapiens isolate donor D clone GP:AF103067_1 D37 immunoglobulin heavy chain K.DTLYLQMNSLR.A 1 2.116 0.086 G variable region mRNA, partial cds. L.YFDSWGQGTLVTVSSASTK.A 2 2.590 0.302 Homo sapiens isolate donor D clone GP:AF103072_1 D48 immunoglobulin heavy chain R.VSISVDTSE.N 1 2.204 0.085 G variable region mRNA, partial cds. Homo sapiens isolate donor D clone GP:AF103077_1 D57 immunoglobulin heavy chain Y.AIDYWGQGTLVTVSSASTK.A 2 3.668 0.238 G variable region mRNA, partial cds. Homo sapiens isolate donor D clone GP:AF103086_1 D7 immunoglobulin heavy chain K.NTIFLQMNSLR.A 1 2.260 0.213 G variable region mRNA, partial cds. Homo sapiens isolate donor D clone GP:AF103094_1 D83 immunoglobulin heavy chain S.GSTYYNPSIK.S 1 1.982 0.107 G variable region mRNA, partial cds. S.TYYNPSIKSR.L 2 2.855 0.239 Homo sapiens clone N105 GP:AF103106_1 immunoglobulin heavy chain variable R.GTLVAVSSASTK.G 1 2.717 0.274 G region mRNA, partial cds. 2 2.782 0.374 Homo sapiens clone N106 GP:AF103107_1 immunoglobulin heavy chain variable Q.GTTVTVSAASTK.A 1 1.823 0.296 G, O region mRNA, partial cds. Homo sapiens clone N110 GP:AF103110_1 immunoglobulin heavy chain variable Y.YFDYWGQGTPVTVSSASTK.G 2 3.953 0.539 G region mRNA, partial cds. Homo sapiens clone N116 GP:AF103114_1 immunoglobulin heavy chain variable W.MNPNSGATNYAQK.F 2 2.986 0.355 P region mRNA, partial cds. Homo sapiens clone N117 IPI:IPI00220120.1 GP:AF103115_1 immunoglobulin heavy chain variable G.SGSYRFDYWGQGTLVTVSSASTK.G 2 2.398 0.201 G (92%) region mRNA, partial cds. K.NTLYLHMNSLR.A 1 2.707 0.286 Homo sapiens clone N118 GP:AF103116_1 immunoglobulin heavy chain variable Q.GTLVIVSSASTK.G 2 2.600 0.374 G region mRNA, partial cds. Homo sapiens clone N126 GP:AF103124_1 immunoglobulin heavy chain variable K.KSLYLQM.N 1 1.826 0.088 G region mRNA, partial cds. K.KSLYLQMN.T 1 1.850 0.097 Homo sapiens clone N13 GP:AF103127_1 immunoglobulin heavy chain variable T.QYNPSLDSR.V 2 3.129 0.116 P region mRNA, partial cds. GP:AF103132_1 Homo sapiens clone N135 R.QAPGQGLEWMGWISIHSG.H 2 2.979 0.243 G Supplementary Table 1 53 immunoglobulin heavy chain variable region mRNA, partial cds. Homo sapiens clone N149 GP:AF103143_1 immunoglobulin heavy chain variable K.NSLYLEMN.S 1 2.373 0.118 G region mRNA, partial cds. K.NSLYLEMNSLR.D 1 2.995 0.165 2 3.841 1.000 Homo sapiens clone N152 GP:AF103146_1 immunoglobulin heavy chain variable K.QDGSEEYYVDSVK.G 2 3.391 0.299 G region mRNA, partial cds. Homo sapiens clone N171 IPI:IPI00161117.1 GP:AF103161_1 immunoglobulin heavy chain variable Y.WGPGTLVTVSSASTK.G 2 2.341 0.222 G (93%) region mRNA, partial cds. Y.YSGTTNYNPSLK.S 2 2.639 0.465 Homo sapiens clone N172 IPI:IPI00161117.1 GP:AF103162_1 immunoglobulin heavy chain variable R.VAISVDTSK.N 1 1.805 0.149 G (93%) region mRNA, partial cds. Homo sapiens clone N179 GP:AF103166_1 immunoglobulin heavy chain variable G.TYYADSVEGR.F 1 1.962 0.205 G region mRNA, partial cds. 2 3.486 0.288 Homo sapiens clone N192 GP:AF103179_1 immunoglobulin heavy chain variable Y.IHWVQQAPGK.G 1 2.288 0.292 G region mRNA, partial cds. Homo sapiens clone N215 A.ADTAVYYCARASAYGPLGDAFDIWGQ. GP:AF103203_1 immunoglobulin heavy chain variable 2 2.657 0.148 A, G, P G region mRNA, partial cds. Homo sapiens clone N218 GP:AF103206_1 immunoglobulin heavy chain variable G.TTITVSSASTK.G 2 2.476 0.162 G, O region mRNA, partial cds. V.WGQGTTITVSSASTK.G 1 2.113 0.126 Homo sapiens clone N245 IPI:IPI00180166.1 GP:AF103227_1 immunoglobulin heavy chain variable I.KSKFDGGTTDYAAPVK.G 2 2.837 0.182 G, O (91%) region mRNA, partial cds. Homo sapiens clone N28 GP:AF103231_1 immunoglobulin heavy chain variable R.IDPSDSYTTYSPSFQGH.V 2 3.375 0.378 G region mRNA, partial cds. Homo sapiens clone N32 GP:AF103235_1 immunoglobulin heavy chain variable F.STGYTYYNPSLKSR.V 2 3.414 0.280 G region mRNA, partial cds. Homo sapiens clone N33 GP:AF103236_1 immunoglobulin heavy chain variable G.YYDYWGQGTLVTVSSASTK.G 2 3.278 0.112 G region mRNA, partial cds. Homo sapiens clone N37 GP:AF103239_1 immunoglobulin heavy chain variable K.SIAYLQMDSLK.T 1 2.482 0.314 G region mRNA, partial cds. Homo sapiens clone N45 GP:AF103247_1 immunoglobulin heavy chain variable A.AAGYAYWGQGTLVTVSSASTK.G 2 3.938 0.146 G region mRNA, partial cds. Homo sapiens clone N57 GP:AF103258_1 immunoglobulin heavy chain variable K.NSLYLQMVSLTA.D 2 2.510 0.145 G region mRNA, partial cds. Homo sapiens clone N61 GP:AF103262_1 immunoglobulin heavy chain variable L.YYSGNSYYNPSLESR.V 2 4.716 0.463 G region mRNA, partial cds. Homo sapiens clone N62 GP:AF103263_1 immunoglobulin heavy chain variable M.ASGYTFSDYYIHWVR.Q 2 2.672 0.342 G, O region mRNA, partial cds. Q.GTLVTVSSASTQ.G 2 3.615 0.291 W.GQGTLVTVSSASTQ.G 1 2.143 0.294 2 3.301 0.441 Y.WGQGTLVTVSSASTQ.G 1 2.898 0.384 2 4.301 0.438 Homo sapiens clone N85 IPI:IPI00182107.1 GP:AF103285_1 immunoglobulin heavy chain variable K.QDGSETYYVDSVK.G 2 3.355 0.425 G (92%) region mRNA, partial cds. Homo sapiens clone N88 GP:AF103288_1 immunoglobulin heavy chain variable Y.YFDFWGQGALVTVSSASTK.G 2 3.503 0.306 G region mRNA, partial cds. Homo sapiens clone N9 GP:AF103290_1 immunoglobulin heavy chain variable R.AEDTAVYYCAKFR.L 2 2.760 0.110 G region mRNA, partial cds. Homo sapiens clone Z104 IPI:IPI00182107.1 GP:AF103301_1 immunoglobulin heavy chain variable R.AEDTAVYYCCSG.W 2 2.527 0.253 G (94%) region mRNA, partial cds. Supplementary Table 1 54 Homo sapiens clone Z108 GP:AF103304_1 immunoglobulin heavy chain variable R.VGSTSYSQTFQGR.V 2 3.059 0.313 G region mRNA, partial cds. Homo sapiens clone Z11 GP:AF103306_1 immunoglobulin heavy chain variable T.TYYNPSLQSR.V 2 2.992 0.321 G region mRNA, partial cds. Homo sapiens clone Z110 GP:AF103307_1 immunoglobulin heavy chain variable S.GYFDYWGQGTLVTVSSASTK.A 2 3.773 0.423 G region mRNA, partial cds. Homo sapiens clone Z4 GP:AF103342_1 immunoglobulin heavy chain variable K.NMLYLQMNSLR.A 2 2.731 0.144 G region mRNA, partial cds. Homo sapiens clone Z73 IPI:IPI00178577.1 GP:AF103362_1 immunoglobulin heavy chain variable T.GWFDSWGQGTLVTVSSASTK.A 2 3.647 0.119 G (96%) region mRNA, partial cds. Homo sapiens clone Z99 GP:AF103372_1 immunoglobulin heavy chain variable R.ATISVDTSK.N 1 1.915 0.229 G region mRNA, partial cds. Homo sapiens isolate donor D clone D119K immunoglobulin kappa light IPI:IPI00178045.1 GP:AF103382_1 M.QALQTPYTFGQGTK.L 2 3.033 0.229 G chain variable region mRNA, partial (96%) cds. Q.ALQTPYTFGQGTK.L 2 3.339 0.256 Homo sapiens isolate donor D clone D125K immunoglobulin kappa light IPI:IPI00003457.1 GP:AF103384_1 N.SYPWTFGQGTK.V 1 1.914 0.100 G chain variable region mRNA, partial (95%) cds. R.ASQSISNWLAWYQQK.P 2 4.467 0.332 R.ASQSISNWLAWYQQKPGK.A 2 3.561 0.218 Homo sapiens isolate donor D clone D14K immunoglobulin kappa light IPI:IPI00141670.1 GP:AF103386_1 R.ASQSVSSSLAWYQQKPGQAPR.L 2 3.276 0.116 G, P chain variable region mRNA, partial (92%) cds. S.SLAWYQQKPGQAPR.L 2 2.329 0.112 Homo sapiens isolate donor D clone D37K immunoglobulin kappa light GP:AF103400_1 R.FSGSGSGTDFNLT.I 2 3.400 0.316 G chain variable region mRNA, partial cds. Homo sapiens isolate donor D clone IPI:IPI00003486.1 GP:AF103401_1 D3K immunoglobulin kappa light chain R.ASQSVRSSYLAWYQQK.L 2 3.305 0.165 G (94%) variable region mRNA, partial cds. Homo sapiens isolate donor D clone D42K immunoglobulin kappa light IPI:IPI00026197.1 GP:AF103402_1 K.SSQSVLHSSNNK.N 2 2.581 0.197 G, O chain variable region mRNA, partial (92%) cds. Homo sapiens isolate donor D clone D46K immunoglobulin kappa light GP:AF103403_1 S.NFAWYQQKPGQAPR.L 2 3.057 0.327 P chain variable region mRNA, partial cds. Homo sapiens isolate donor D clone D47K immunoglobulin kappa light IPI:IPI00030205.1 GP:AF103404_1 N.TYLAWYQQK.P 1 2.289 0.276 G chain variable region mRNA, partial (92%) cds. Homo sapiens isolate donor D clone GP:AF103406_1 D4K immunoglobulin kappa light chain A.GYLAWYQQQ.P 2 2.626 0.196 G variable region mRNA, partial cds. A.WYQQQPGR.A 1 2.513 0.253 Y.LAWYQQQ.P 1 2.183 0.150 Homo sapiens isolate donor D clone D56K immunoglobulin kappa light IPI:IPI00026197.1 GP:AF103408_1 F.SGSGSGTDFTLTIRS.L 2 3.545 0.462 A, G, O, P chain variable region mRNA, partial (93%) cds. L.YRSNNENYLAWYQQ.K 2 3.087 0.174 R.FSGSGSGTDFTLTIRS.L 1 2.333 0.177 2 4.538 0.454 Homo sapiens isolate donor D clone D66K immunoglobulin kappa light GP:AF103414_1 R.ASESVMSSYLAWYQQKPGQAPR.L 2 2.888 0.150 G chain variable region mRNA, partial cds. Homo sapiens isolate donor D clone D72K immunoglobulin kappa light GP:AF103417_1 R.LLIYDASTR.A 1 1.971 0.179 G chain variable region mRNA, partial cds. Homo sapiens isolate donor D clone IPI:IPI00003457.1 GP:AF103421_1 K.ASILESGVPSR.F 2 2.980 0.234 G D85K immunoglobulin kappa light (92%) Supplementary Table 1 55 chain variable region mRNA, partial cds. Homo sapiens isolate donor D clone D92K immunoglobulin kappa light IPI:IPI00022862.1 GP:AF103424_1 R.ASQSVSGNLAWYQQK.P 2 2.562 0.156 G chain variable region mRNA, partial (92%) cds. R.ASQSVSGNLAWYQQKPGQAPR.L 2 3.449 0.153 R.LLIHGASTR.A 1 2.080 0.085 S.GNLAWYQQK.P 2 2.692 0.327 Homo sapiens isolate donor N clone N104K immunoglobulin kappa light IPI:IPI00024136.1 GP:AF103427_1 R.ASQSVSTYLAWYQQKPGQAPR.L 2 3.397 0.081 G chain variable region mRNA, partial (98%) cds. Homo sapiens isolate donor N clone N105K immunoglobulin kappa light GP:AF103428_1 K.YLAWYQHKPGQAPR.L 2 2.299 0.255 G chain variable region mRNA, partial cds. S.APWTFGQGTK.V 1 2.520 0.152 2 2.781 0.215 Homo sapiens isolate donor N clone N111K immunoglobulin kappa light IPI:IPI00160257.2 GP:AF103433_1 A.SSLHSGVPSR.F 1 2.140 0.108 G chain variable region mRNA, partial (94%) cds. R.ASQGISSWLAWYQQK.P 2 2.440 0.288 R.ASQGISSWLAWYQQKPGK.A 2 3.547 0.154 Homo sapiens isolate donor N clone N119K immunoglobulin kappa light IPI:IPI00003486.1 GP:AF103435_1 R.FSGSGSGTDFTLTINR.L 2 4.490 0.564 G, P chain variable region mRNA, partial (92%) cds. Homo sapiens isolate donor N clone N120K immunoglobulin kappa light GP:AF103437_1 A.SQNINSWLAWYQQKPGK.A 2 2.901 0.115 G, O chain variable region mRNA, partial cds. T.EFTLTISSLQADDFATYY.C 2 2.991 0.088 Homo sapiens isolate donor N clone N121K immunoglobulin kappa light IPI:IPI00026175.1 GP:AF103438_1 M.QALQTPWTFGQGTK.V 2 3.307 0.350 G chain variable region mRNA, partial (93%) cds. Homo sapiens isolate donor N clone N138K immunoglobulin kappa light GP:AF103443_1 R.LIYTASSLQSGVPSR.F 2 3.134 0.288 G, O chain variable region mRNA, partial cds. R.NDLAWYQQK.P 2 2.242 0.114 R.NDLAWYQQKPGK.A 2 2.408 0.253 Homo sapiens isolate donor N clone N145K immunoglobulin kappa light GP:AF103445_1 R.FSGSGAGTDFTLK.I 1 2.716 0.280 G, O, P chain variable region mRNA, partial cds. 2 3.682 0.346 R.SSQSLVHSDGNTYLSWLQQR.P 2 5.209 0.516 3 4.354 0.385 Homo sapiens isolate donor N clone N152K immunoglobulin kappa light IPI:IPI00022862.1 GP:AF103449_1 R.ASQSVSFNLAWYQQKPGQAPR.L 2 4.247 0.147 G chain variable region mRNA, partial (91%) cds. Homo sapiens isolate donor N clone N156K immunoglobulin kappa light IPI:IPI00026197.1 GP:AF103451_1 A.WYQQKPGEPPK.L 2 2.932 1.000 G, O, P chain variable region mRNA, partial (94%) cds. K.LLINWASTR.E 2 2.585 0.213 K.NYLAWYQQKPGEPPK.L 2 4.804 0.303 Homo sapiens isolate donor N clone N160K immunoglobulin kappa light IPI:IPI00026197.1 GP:AF103455_1 K.SSRSVLYSSNNK.N 1 2.267 0.135 G chain variable region mRNA, partial (91%) cds. Homo sapiens isolate donor N clone N161K immunoglobulin kappa light GP:AF103456_1 G.SHLAWYQQK.P 1 3.071 0.203 G chain variable region mRNA, partial cds. Homo sapiens isolate donor N clone N170K immunoglobulin kappa light IPI:IPI00003457.1 GP:AF103459_1 S.WLAWYQQKPGR.A 1 2.245 0.259 G chain variable region mRNA, partial (91%) cds. 2 3.086 0.248 Supplementary Table 1 56 Homo sapiens isolate donor N clone N174K immunoglobulin kappa light GP:AF103462_1 T.VYLAWYQHK.P 1 2.370 0.120 G chain variable region mRNA, partial cds. V.RTVYLAWYQHKPGQAPR.L 2 2.327 0.108 Homo sapiens isolate donor N clone N188K immunoglobulin kappa light GP:AF103466_1 R.ASQSITNWLAWYQQKPGK.G 2 2.775 0.242 G chain variable region mRNA, partial cds. Homo sapiens isolate donor N clone N196K immunoglobulin kappa light IPI:IPI00024136.1 GP:AF103471_1 R.ASQSVSNYLAWYQQK.P 1 2.424 0.257 G chain variable region mRNA, partial (97%) cds. 2 3.695 0.243 R.ASQSVSNYLAWYQQKPGQAPR.L 2 2.671 0.138 Homo sapiens isolate donor N clone N205K immunoglobulin kappa light IPI:IPI00030206.1 GP:AF103477_1 R.FSGSGSGTDFSLTITR.L 2 2.538 0.221 G chain variable region mRNA, partial (93%) cds. Homo sapiens isolate donor N clone N210K immunoglobulin kappa light IPI:IPI00026197.1 GP:AF103482_1 K.NYLAWFQQKPGQPPK.L 2 3.749 0.396 G chain variable region mRNA, partial (93%) cds. Homo sapiens isolate donor N clone N21K immunoglobulin kappa light IPI:IPI00007852.1 GP:AF103486_1 R.ASQGISDYLAWYQQK.P 2 2.795 0.197 G chain variable region mRNA, partial (95%) cds. R.ASQGISDYLAWYQQKPGK.V 2 2.510 0.091 S.DYLAWYQQK.P 1 2.947 0.240 2 3.417 0.228 Homo sapiens isolate donor N clone N221K immunoglobulin kappa light IPI:IPI00053682.1 GP:AF103487_1 R.ASQSISDYLNWYQQKPGK.A 2 4.092 1.000 G chain variable region mRNA, partial (91%) cds. Homo sapiens isolate donor N clone N222K immunoglobulin kappa light GP:AF103488_1 K.LLIYTASTLQSGVPSR.F 2 2.758 0.258 O chain variable region mRNA, partial cds. Homo sapiens isolate donor N clone N227K immunoglobulin kappa light IPI:IPI00007852.1 GP:AF103489_1 R.ASQGLSNYLAWYQQKPGK.V 2 3.497 0.104 G chain variable region mRNA, partial (95%) cds. Homo sapiens isolate donor N clone N228K immunoglobulin kappa light GP:AF103490_1 K.LLIFDASNLETGVPSR.F 2 3.686 0.259 G, O chain variable region mRNA, partial cds. Q.ASQDIINFLNWYQQKPGK.A 2 3.781 0.210 Homo sapiens isolate donor N clone N237K immunoglobulin kappa light IPI:IPI00026197.1 GP:AF103493_1 K.NYLAWYQQQPGQPPK.L 1 2.273 0.173 G, P chain variable region mRNA, partial (98%) cds. 2 4.095 0.375 L.AWYQQQPGQPPK.L 2 2.204 0.146 Y.LAWYQQQPGQ.P 2 3.273 1.000 Y.STPWTFGQGTK.V 1 2.386 0.274 Homo sapiens isolate donor N clone N27K immunoglobulin kappa light GP:AF103501_1 S.NYLAWYQHK.P 1 2.495 0.106 G chain variable region mRNA, partial cds. S.NYLAWYQHKPGQAPR.L 2 2.264 0.101 Homo sapiens isolate donor N clone GP:AF103502_1 N2K immunoglobulin kappa light chain G.WYQQKPGKAPR.R 2 2.780 0.198 G, P variable region mRNA, partial cds. W.YQQKPGKAPR.R 2 2.340 0.130 Homo sapiens isolate donor N clone N40K immunoglobulin kappa light IPI:IPI00030205.1 GP:AF103506_1 A.SQSVSFSYLAWYQQKPGQAPR.L 2 3.443 0.149 G chain variable region mRNA, partial (92%) cds. R.FSGGGSGTDFTLTISR.L 2 2.805 0.357 Homo sapiens isolate donor N clone N51K immunoglobulin kappa light GP:AF103511_1 R.ASQSVSSDLAWYQQK.P 2 5.269 0.342 G, O chain variable region mRNA, partial cds. R.ASQSVSSDLAWYQQKPGQAPR.L 2 4.899 0.088 Supplementary Table 1 57 S.SDLAWYQQK.P 2 2.621 0.297 Homo sapiens isolate donor N clone N77K immunoglobulin kappa light GP:AF103524_1 K.LLLYWASTR.E 1 1.925 0.246 G, P chain variable region mRNA, partial cds. 2 3.043 0.245 L.LYWASTR.E 1 1.846 0.188 Homo sapiens isolate donor N clone N82K immunoglobulin kappa light IPI:IPI00007884.1 GP:AF103526_1 N.YNLAWYQQK.P 1 2.721 0.089 G chain variable region mRNA, partial (92%) cds. 2 2.503 0.092 Homo sapiens isolate donor N clone N84K immunoglobulin kappa light GP:AF103527_1 R.ASQSITSYLNWYQQK.P 2 2.442 0.137 G, O chain variable region mRNA, partial cds. R.ASQSITSYLNWYQQKPGK.A 2 2.471 0.283 Homo sapiens isolate donor N clone N88K immunoglobulin kappa light GP:AF103529_1 K.VLIYDASNLETGVPSR.F 2 3.149 0.373 G, O chain variable region mRNA, partial cds. Q.YNDHPLTFGPGTK.V 2 2.412 0.111 T.WYQKKPGK.A 1 1.874 0.091 Homo sapiens isolate donor N clone N95K immunoglobulin kappa light GP:AF103533_1 R.ASQSISTYLNWYQQKPGQ.A 2 3.429 0.098 G chain variable region mRNA, partial cds. V.ASNLQDGVPSR.F 2 2.492 0.134 Homo sapiens isolate donor N clone N99K immunoglobulin kappa light GP:AF103535_1 N.NLNWYQQK.V 2 2.375 0.172 G chain variable region mRNA, partial cds. S.NNLNWYQQK.V 2 2.504 0.181 Homo sapiens isolate donor N clone IPI:IPI00181894.1 GP:AF103536_1 N9K immunoglobulin kappa light chain K.YDSAPWTFGQGTK.V 2 2.864 0.348 G, O (94%) variable region mRNA, partial cds. S.PSSLSASVGDRVTITCRASQGISTY.L 2 2.479 0.176 Homo sapiens isolate donor Z clone Z101K immunoglobulin kappa light GP:AF103537_1 K.LLIYAASSLHSGVPSR.F 2 2.743 0.187 G chain variable region mRNA, partial cds. Y.AASSLHSGVPSR.F 2 3.396 0.334 Homo sapiens isolate donor Z clone Z105K immunoglobulin kappa light IPI:IPI00178045.1 GP:AF103539_1 R.ASGVPDKFSGSGSGTDFTLK.I 3 3.797 0.405 G, O, P chain variable region mRNA, partial (91%) cds. Homo sapiens isolate donor Z clone Z110K immunoglobulin kappa light IPI:IPI00026197.1 GP:AF103542_1 N.QNYLAWYQQK.P 1 2.718 0.102 G chain variable region mRNA, partial (96%) cds. Homo sapiens isolate donor Z clone Z11K immunoglobulin kappa light GP:AF103547_1 R.ASQSVTSNLAWYQQK.P 2 3.458 0.290 G chain variable region mRNA, partial cds. R.ASQSVTSNLAWYQQKPGQAPR.L 2 4.560 0.153 Homo sapiens isolate donor Z clone Z126K immunoglobulin kappa light IPI:IPI00003457.1 GP:AF103550_1 N.SYAYTFGQGTK.L 1 1.861 0.204 G chain variable region mRNA, partial (96%) cds. Homo sapiens isolate donor Z clone IPI:IPI00178190.1 GP:AF103555_1 Z1K immunoglobulin kappa light chain K.SSQSLLHGDGK.T 2 3.286 0.347 G (93%) variable region mRNA, partial cds. Homo sapiens isolate donor Z clone Z20K immunoglobulin kappa light GP:AF103556_1 Q.SVNSNLAWYQQK.P 2 3.195 0.132 G chain variable region mRNA, partial cds. R.ASQSVNSNLAWYQQK.P 2 2.349 0.340 Homo sapiens isolate donor Z clone Z24K immunoglobulin kappa light IPI:IPI00024136.1 GP:AF103558_1 R.LLIYDASYR.A 2 2.910 0.236 G chain variable region mRNA, partial (97%) cds. Homo sapiens isolate donor Z clone IPI:IPI00026197.1 GP:AF103562_1 Z2K immunoglobulin kappa light chain N.CRSSQSVLYSSNSKNYLAW.Y 2 3.100 0.081 O, P (97%) variable region mRNA, partial cds.
Supplementary Table 1 58 Homo sapiens isolate donor Z clone Z46K immunoglobulin kappa light GP:AF103569_1 R.ASQSVSSSSLAWYQQR.P 2 2.776 0.267 G chain variable region mRNA, partial cds. S.SSLAWYQQR.P 2 2.578 0.168 Homo sapiens isolate donor Z clone Z47K immunoglobulin kappa light IPI:IPI00003486.1 GP:AF103570_1 P.MYTFGQGTK.L 1 1.865 0.096 G chain variable region mRNA, partial (95%) cds. R.ASQSVSSIYLAWYQQK.P 2 2.823 0.267 R.ASQSVSSIYLAWYQQKPGQAPR.L 2 2.645 0.184 Homo sapiens isolate donor Z clone Z55K immunoglobulin kappa light GP:AF103574_1 A.ASNLDTGVPSR.F 1 2.258 0.268 G, P chain variable region mRNA, partial cds. 2 2.514 0.198 T.NSLNWYQQK.P 2 2.359 0.113 Homo sapiens isolate donor Z clone Z61K immunoglobulin kappa light IPI:IPI00024136.1 GP:AF103576_1 S.NYLGWYQQK.P 1 2.374 0.307 G chain variable region mRNA, partial (94%) cds. 2 2.540 0.171 Homo sapiens isolate donor Z clone Z75K immunoglobulin kappa light GP:AF103580_1 S.SSYLAWYQQR.P 2 2.556 0.313 G chain variable region mRNA, partial cds. Homo sapiens isolate donor Z clone Z89K immunoglobulin kappa light GP:AF103583_1 S.SPHTFGQGTK.L 1 2.027 0.122 G chain variable region mRNA, partial cds. Homo sapiens isolate donor Z clone Z94K immunoglobulin kappa light GP:AF103586_1 K.NHLAWYQQK.P 1 3.444 0.215 G chain variable region mRNA, partial cds. 2 2.639 0.162 K.NHLAWYQQKPGQPPK.L 2 3.009 0.227 Homo sapiens isolate donor D clone D108L immunoglobulin lambda light GP:AF103592_1 R.FSGSILGNK.A 1 2.294 0.134 G, O, P chain variable region mRNA, partial cds. 2 2.908 0.100 Homo sapiens isolate donor D clone D11L immunoglobulin lambda light GP:AF103594_1 K.NVHWYQQKPGQAPVLVIYR.D 2 5.016 0.460 G chain variable region mRNA, partial cds. 3 3.511 0.229 Homo sapiens isolate donor D clone D13L immunoglobulin lambda light GP:AF103595_1 K.LMIYEVSNRPSGVSNR.F 2 2.596 0.128 G, O chain variable region mRNA, partial cds. L.MIYEVSNRPSGVSNR.F 2 2.802 0.110 M.IYEVSNRPSGVSNR.F 2 2.708 0.182 Y.EVSNRPSGVSNR.F 2 2.284 0.117 Homo sapiens isolate donor D clone D58L immunoglobulin lambda light GP:AF103605_1 R.DSNRPSGIPER.F 2 2.738 0.151 G, P chain variable region mRNA, partial cds. Homo sapiens isolate donor D clone D62L immunoglobulin lambda light IPI:IPI00017248.1 GP:AF103606_1 K.NDRPSGIPDR.F 2 2.940 0.116 G chain variable region mRNA, partial (92%) cds. Homo sapiens isolate donor D clone D68L immunoglobulin lambda light IPI:IPI00152644.1 GP:AF103607_1 N.NFVSWYQQFPGTAPK.L 2 4.082 0.417 G chain variable region mRNA, partial (93%) cds. Homo sapiens isolate donor D clone D93L immunoglobulin lambda light GP:AF103610_1 G.RPSGLPER.F 1 2.045 0.202 G, P chain variable region mRNA, partial cds. K.NVHWYQQR.P 1 2.376 0.340 2 2.512 0.203 Homo sapiens isolate donor D clone GP:AF103611_1 D94L immunoglobulin lambda light W.DDSHLVFGGGTK.L 2 2.749 0.249 G chain variable region mRNA, partial Supplementary Table 1 59 cds. Homo sapiens isolate donor N clone N112L immunoglobulin lambda light GP:AF103615_1 K.LLIYGNINRPSGVPDR.F 2 2.638 0.183 G chain variable region mRNA, partial cds. Homo sapiens isolate donor N clone N124L immunoglobulin lambda light GP:AF103619_1 K.NNERPSGVPDR.F 2 2.811 0.188 A, G, O, P chain variable region mRNA, partial cds. Homo sapiens isolate donor N clone N139L immunoglobulin lambda light GP:AF103625_1 R.SVHWYQQE.P 2 2.834 0.141 G, O chain variable region mRNA, partial cds. Homo sapiens isolate donor N clone N186L immunoglobulin lambda light GP:AF103642_1 N.TVTWYQQLPGTAPK.V 2 2.594 0.345 G, O chain variable region mRNA, partial cds. S.NTVTWYQQLPGTAPK.V 2 3.483 0.378 Homo sapiens isolate donor N clone N187L immunoglobulin lambda light GP:AF103643_1 K.PGQAPVLVLYDTR.D 2 3.710 0.268 G chain variable region mRNA, partial cds. Homo sapiens isolate donor N clone N209L immunoglobulin lambda light GP:AF103651_1 N.WYQQLPGAAPK.L 2 2.659 0.151 G chain variable region mRNA, partial cds. Homo sapiens isolate donor N clone N213L immunoglobulin lambda light GP:AF103653_1 A.DTNRPSGVPDR.F 2 2.584 0.082 G chain variable region mRNA, partial cds. K.LLIYADTNRPSGVPDR.F 2 2.618 0.140 Homo sapiens isolate donor N clone N215L immunoglobulin lambda light GP:AF103654_1 R.SNQRPSGVPDR.F 2 2.514 0.126 O chain variable region mRNA, partial cds. Homo sapiens isolate donor N clone N217L immunoglobulin lambda light GP:AF103656_1 S.HTVNWYQQLPGTAPK.L 1 3.396 0.145 G, O chain variable region mRNA, partial cds. 2 4.918 0.377 Homo sapiens isolate donor N clone N232L immunoglobulin lambda light GP:AF103663_1 K.PGQAPVLIIYQ.D 2 3.759 0.233 G chain variable region mRNA, partial cds. Homo sapiens isolate donor N clone N39L immunoglobulin lambda light GP:AF103671_1 K.LLIYNDNQR.P 2 2.886 0.119 G chain variable region mRNA, partial cds. Homo sapiens isolate donor N clone N44L immunoglobulin lambda light GP:AF103674_1 K.PGQAPVLVVCDCSDR.P 2 2.576 0.283 G chain variable region mRNA, partial cds. N.SVNWYQQK.P 1 2.251 0.095 S.DRPSEIPDR.Y 2 2.983 0.087 Homo sapiens isolate donor N clone N70L immunoglobulin lambda light GP:AF103685_1 R.FSGSNSGDTATLTINR.V 2 4.622 0.534 G chain variable region mRNA, partial cds. Homo sapiens isolate donor N clone N76L immunoglobulin lambda light GP:AF103687_1 N.IGSNPVNWYQQLPGTAPK.L 2 3.616 0.219 G chain variable region mRNA, partial cds. S.NPVNWYQQLPGTAPK.L 2 2.268 0.222 Homo sapiens isolate donor Z clone Z125L immunoglobulin lambda light GP:AF103702_1 N.TVSWYQQLPGTAPK.L 2 2.280 0.242 G, O chain variable region mRNA, partial cds. S.NTVSWYQQLPGTAPK.L 2 3.247 0.275 Homo sapiens isolate donor Z clone Z33L immunoglobulin lambda light GP:AF103707_1 Y.VWWYQQLPGTAPK.L 2 3.623 0.140 G chain variable region mRNA, partial cds. Homo sapiens isolate donor Z clone Z36L immunoglobulin lambda light GP:AF103708_1 Y.RPSGVSIR.F 1 1.995 0.121 G chain variable region mRNA, partial cds. Supplementary Table 1 60 Homo sapiens isolate donor Z clone Z3L immunoglobulin lambda light GP:AF103711_1 E.ADYYCETWDSSLNSVVFGGGTKLAV.L 2 2.418 0.139 G chain variable region mRNA, partial cds. K.LIIYDNVKRPSGIPDR.F 2 2.383 0.214 Homo sapiens isolate donor Z clone Z99L immunoglobulin lambda light GP:AF103725_1 N.IGSNTVDWYQQLPGTAPK.L 1 3.948 0.252 G, O, P chain variable region mRNA, partial cds. 2 4.643 0.348 N.TVDWYQQLPGTAPK.L 1 2.868 0.128 2 4.037 0.157 S.NTVDWYQQLPGTAPK.L 2 3.906 0.339 Homo sapiens clone P11 anti- phospholipid immunoglobulin heavy GP:AF103770_1 P.HYFDNWGQGALVTVSSASTK.G 2 3.048 0.303 G chain VH-D-J-C region mRNA, partial cds. Homo sapiens clone B22 anti- phospholipid immunoglobulin light IPI:IPI00007852.1 GP:AF103772_1 N.LLIYGASTLQSGVPSR.F 2 2.506 0.166 O chain VL-J-C region mRNA, partial (92%) cds. Homo sapiens immunoglobulin kappa GP:AF103873_1 light chain precursor, mRNA, partial G.EIVMMQSPATLSVSPGER.A 2 3.256 0.304 G, O cds. Homo sapiens transcriptional co- IPI:IPI00033695.1 GP:AF104254_1 activator CRSP77 (CRSP77) mRNA, D.HLYVLEHNLHLLIR.E 2 2.246 0.115 G, P (99%) partial cds. I.ISQPFPSLQLSISLCHS.S 2 3.468 0.217 IPI:IPI00063938.1 GP:AF104260_1 Homo sapiens hiwi mRNA, partial cds. I.PLKLVMIVGID.C 2 2.702 0.107 G (97%) Homo sapiens large tumor suppressor IPI:IPI00005858.1 GP:AF104413_1 1 (LATS1) mRNA, complete cds; L.QDLQAAGFDEDMVIQALQK.T 2 2.601 0.219 O (91%) putative serine threonine kinase. Homo sapiens actin-associated protein 2E4/kaptin (2E4) mRNA, 2E4- 1 allele, complete cds; found at IPI:IPI00013116.1 GP:AF105369_1 barbed ends of actin filament in T.KDRPLQDEYSVLVASMLEPAVV.Y 2 2.824 0.099 A (96%) platelets, fibroblasts, neuronal growth cones, intestinal microvilli and stereocilia of the inner ear. Homo sapiens BAC RG73E2 prion- GP:AF106918_1 like protein (PRND) gene, complete K.EAFVTGCINATQAANQGEF.Q 2 3.227 0.130 G cds. Homo sapiens clone MD10 GP:AF107240_1 immunoglobulin heavy chain variable R.DTSINTAYMELSGLR.S 2 3.085 0.413 O region mRNA, partial cds. Homo sapiens clone MD01 GP:AF107242_1 immunoglobulin lambda light chain Y.PSWYQQTPGQAPR.T 2 4.110 0.369 G variable region mRNA, partial cds. Homo sapiens clone MD09 GP:AF107249_1 immunoglobulin lambda light chain Y.PSWYQQKPGQ.A 1 2.618 1.000 G variable region mRNA, partial cds. 2 3.350 1.000 Homo sapiens clone MD10 GP:AF107250_1 immunoglobulin lambda light chain S.ITCSADKLGEKY.V 2 3.024 0.089 A variable region mRNA, partial cds. Homo sapiens mucin 5B (MUC5B) IPI:IPI00012165.3 GP:AF107890_1 A.AQLPDMPLEELGQQVDCDRMRG.L 2 2.767 0.167 A gene, partial cds. (94%) S.YELILQEGTFKAVARGPGGDPPYKIR.Y 2 2.217 0.177 Homo sapiens ubinuclein (UBN1) GP:AF108459_1 gene, exons 13, 14, 15, 16, 17, 18 and G.LPAPLEK.R 1 1.877 0.087 O complete cds. Homo sapiens immunoglobin light IPI:IPI00022862.1 GP:AF109407_1 R.ASQSVSSNLAWYQQKPGQPPR.L 2 3.402 0.270 G chain mRNA, partial cds. (95%) Homo sapiens S164 gene, partial cds; PS1 and hypothetical protein genes, complete cds; and S171 gene, partial cds; This gene is predicted by IPI:IPI00009224.2 GP:AF109907_3 R.VLGELTISGLPPTVTVPEG.D 1 2.344 0.141 G Genscan; exons between 169766- (98%) 172443 are supported by EST AA930352; exons between 183120- 186473 are supported Homo sapiens MSTP015 (MST015) IPI:IPI00017513.1 GP:AF110225_1 D.PGSWAQLEHPDALAKK.A 1 2.294 0.183 G mRNA, complete cds. (97%) GP:AF110481_1 Homo sapiens clone 2a -.EVQLVQSGVEVK.Q 1 2.901 0.206 G, O Supplementary Table 1 61 immunoglobulin E heavy chain (IGE) mRNA, partial cds; VH-Ce. 2 3.939 0.197 Homo sapiens clone 4 GP:AF110485_1 immunoglobulin E heavy chain (IGE) -.EVQLIQSGAEVK.K 1 2.482 0.189 G, O mRNA, partial cds; VH-Ce. 2 3.347 0.172 L.SISCKGSDNR.F 2 2.276 0.140 T.LHWSSLK.A 1 2.142 0.176 Homo sapiens immunoglobulin E IPI:IPI00018563.3 GP:AF110486_1 heavy chain (IGE) mRNA, partial cds; -.EVQLLQSGAEVK.N 2 3.238 0.152 G (92%) VH-Ce. Homo sapiens clone 6 IPI:IPI00018563.3 GP:AF110487_1 immunoglobulin E heavy chain (IGE) K.SIDTAYLQWSSLK.A 1 3.040 0.265 G (94%) mRNA, partial cds; VH-Ce. 2 3.667 0.395 Homo sapiens clone 8 GP:AF110489_1 immunoglobulin E heavy chain (IGE) -.EVQLVQSGTEVK.K 1 2.816 0.217 G mRNA, partial cds; VH-Ce. 2 3.571 0.200 Homo sapiens PPP1R5 gene, IPI:IPI00152588.1 GP:AF110824_1 complete cds; protein targeting to R.TVTGTVKVKN.V 1 1.963 0.081 O (93%) glycogen. Homo sapiens patient BOU GP:AF111188_1 immunoglobulin heavy chain variable -.EVQLVQPAGEVK.K 2 2.987 0.091 G region gene, partial cds. Homo sapiens patient NIC GP:AF111192_1 immunoglobulin heavy chain variable -.HVQLVQSGAEVK.K 1 3.499 0.321 G, O region gene, partial cds. 2 4.076 0.255 Homo sapiens heat shock protein IPI:IPI00008421.1 GP:AF112210_1 hsp70-related protein mRNA, M.IECSARDILVKGVDESGASR.F 2 2.724 0.090 P (97%) complete cds; hsr-1; NST-1. Homo sapiens unknown mRNA; 3-7 GP:AF112218_1 E.KENSQLDEENL.E 2 3.079 0.087 O, P gene product. H.ELEKENLQLKAKL.H 2 3.015 0.112 Synthetic construct humanized anti- GP:AF112400_1 DREG-200 immunoglobulin light chain S.TPLTFGQGTK.V 1 2.193 0.287 G variable region mRNA, partial cds. Homo sapiens MSTP041 mRNA, GP:AF113221_1 V.IYSIDKAKK.F 1 1.830 0.134 G complete cds. Homo sapiens MSTP045 mRNA, GP:AF113225_1 C.SKLETLGIGQRTPFRI.G 1 2.404 0.130 A complete cds. Homo sapiens histone acetyltransferase MORF mRNA, IPI:IPI00007837.1 GP:AF113514_1 L.DKKTVSEQLELSVQDGSVLK.V 2 2.523 0.092 O, P complete cds; similar to Homo sapiens (91%) MOZ. S.SLPPVSLLPHEK.D 2 2.564 0.101 Homo sapiens clone dn1 IPI:IPI00220120.1 GP:AF115107_1 immunoglobulin heavy chain variable -.EVQQLESGGGLVQPGGSLR.L 2 2.886 0.157 G (93%) region mRNA, partial cds. Homo sapiens clone sc2 IPI:IPI00182107.1 GP:AF115121_1 immunoglobulin heavy chain variable Y.AGGWFDPWGQGTLVTVSSASTK.G 2 3.407 0.181 G (96%) region mRNA, partial cds. Homo sapiens clone sc8 GP:AF115127_1 immunoglobulin heavy chain variable -.QLQLVESGGGVVQPGR.S 1 2.835 0.192 G, O region mRNA, partial cds. 2 4.825 0.383 Homo sapiens clone sc9 G.LGGAGAYFDYWGQGTLVTVSSASTK. GP:AF115128_1 immunoglobulin heavy chain variable 2 3.562 0.096 G G region mRNA, partial cds. Homo sapiens clone DKAL1 lambda 1 GP:AF115351_1 immunoglobulin light chain variable G.NNYVSWYQQLPGAAPK.L 2 2.940 0.373 G region mRNA, partial cds. Homo sapiens clone RTML2 lambda 2 GP:AF115353_1 immunoglobulin light chain variable K.LIIYEVSLRPSGVPDR.F 2 2.545 0.220 P region mRNA, partial cds. Homo sapiens clone JCOL3 lambda 3 GP:AF115354_1 immunoglobulin light chain variable D.TKRPSGIPDR.F 2 3.063 0.168 G region mRNA, partial cds. K.AGQSPVLVIYEDTK.R 2 3.503 0.366 Homo sapiens clone MAOK1 kappa 1 GP:AF115361_1 immunoglobulin light chain variable K.LLIYDASNLQ.K 2 2.823 0.083 O region mRNA, partial cds.
Supplementary Table 1 62 Homo sapiens isolate 1274 GP:AF116541_1 immunoglobulin light chain variable K.LLIYYDDLLPSGVSDR.F 2 3.363 0.270 O region gene, partial cds. Homo sapiens PRO1708 mRNA, IPI:IPI00216773.1 GP:AF116645_1 complete cds; predicted protein of F.KPLAEEPQNLIKQNCELFEQLGEYK.F 3 3.875 0.198 A (99%) HQ1708. Homo sapiens PRO2013 mRNA, GP:AF116682_1 complete cds; predicted protein of M.NVDHEVNLLV.E 1 2.279 0.111 A HQ2013. Homo sapiens heme-binding protein IPI:IPI00148063.1 GP:AF117615_1 R.EAMPKVAKYAGGTNDKGIGMGMTVP.I 2 3.138 0.087 P (HBP) mRNA, complete cds. (99%) Lycopersicon esculentum putative copper/zinc superoxide dismutase copper chaperone precursor (CCS) mRNA, partial cds; nuclear gene for GP:AF117707_1 A.RLIGQGVPDDF.L 1 2.340 0.107 P chloroplast product; similar to Saccharomyces cerevisiae Lys7 and Homo sapiens CCS; complements aerobic lysine auxo Homo sapiens thyroid hormone receptor-associated protein complex IPI:IPI00000913.1 GP:AF117754_1 C.VCNMNIKGADVGVYIPDPTQEAQYR.C 2 2.580 0.090 A, G, P component TRAP240 mRNA, (94%) complete cds. K.VGIPTDGDSHA.V 1 1.930 0.152 R.LGRIGHGELKDWSCLLSR.R 2 2.787 0.161 S.GGLCEEATAAKVASWDFVEATQR.T 2 2.370 0.148 Homo sapiens anti-CD30 scFv AK30 GP:AF117956_1 -.QVQLQQSGAEVK.K 2 2.839 0.156 G, P mRNA, partial cds. R.DTSINTAYMELR.R 2 2.931 0.264 W.IDPNSGATTYAQKFQGR.L 2 2.536 0.234 Homo sapiens polycystin-2-like protein GP:AF118125_1 (PKD2L2) mRNA, complete cds; K.ERLEKKYYSMEIQDDYQP.V 2 2.865 0.130 O autosomal dominant. Homo sapiens DNb-5 mRNA, partial GP:AF118274_1 L.SPXFGGGF.G 1 2.632 0.202 O, P cds; deleted in neuroblastoma. Homo sapiens PRO1851 mRNA, IPI:IPI00218192.1 GP:AF119856_1 complete cds; predicted protein of F.HNFMER.L 2 2.581 0.240 G, O, P (97%) HQ1851. F.RPGVLSSR.Q 2 2.927 0.129 F.STEATQWRPSLVPASAENVNK.A 2 4.039 0.418 3 3.819 0.235 G.SEMVVAGK.L 1 1.829 0.172 H.ASPEHVVVTR.N 2 2.906 0.452 K.AGFSWIEVTFK.N 2 4.079 0.327 K.AGFSWIEVTFKNPLVWVHASPEHVVVT 3 6.373 0.442 R.N K.ETLFSVMPGLK.M 1 2.865 0.370 2 2.894 0.337 K.GSEMVVAGK.L 1 2.199 0.165 2 3.146 0.225 K.ILDDLSPR.D 1 2.382 0.148 2 2.689 0.096 K.ILDDLSPRDQFNLIVFSTEATQWRPSLV 3 4.089 0.250 PASAENVNK.A K.LALDNGGLAR.R 2 2.851 0.174 K.LQDRGPDVLTATVSGK.L 2 4.672 0.454 K.NPLVWVHASPEHVVVT.R 2 3.585 0.461 K.NPLVWVHASPEHVVVTR.N 2 5.329 0.499 3 5.575 0.322 K.NVVFVIDK.S 1 3.040 0.235 2 2.896 0.218 K.PDDQEQSQVAEK.P 2 2.494 0.205 K.TGLLLLSDPDK.V 1 3.136 0.230 2 3.807 0.231 K.TGLLLLSDPDKVTIGLLFWDGR.G 2 3.782 0.445 K.TGLLLLSDPDKVTIGLLFWDGRGEGLR. 3 3.844 0.261 L K.WKETLFSVMPGLK.M 2 4.569 0.330 K.YIFHNFMER.L 2 2.624 0.211 L.IILLTDGDPTVGETNPR.S 2 3.479 0.468
Supplementary Table 1 63 L.PGPPDVPDHAAYHPFR.R 2 3.832 0.431 L.TSMVVTKPDDQEQSQVAEKPMEGESR 3 4.313 0.367 .N M.NFRPGVLSSR.Q 2 2.809 0.083 M.VVTKPDDQEQSQVAEK.P 2 2.458 0.241 M.VVTKPDDQEQSQVAEKPMEGESR.N 3 3.820 0.312 N.FRPGVLSSR.Q 2 2.789 0.300 N.LLSDPEQGVEVTGQYER.E 2 4.543 0.477 N.PLVWVHASPEHVVVTR.N 2 2.298 0.161 3 5.450 0.469 P.DVLTATVSGK.L 1 1.924 0.302 P.LVWVHASPEHVVVTR.N 2 4.025 0.407 3 4.613 0.378 R.DQFNLIVFSTEATQWRPSLVPASAENV 2 2.847 0.279 NK.A 3 6.489 0.450 R.DTDRFSSHVGGTLGQFYQEVLWGSPA 3 3.967 0.214 ASDDGRR.T R.FSSHVGGTLGQFYQEVLWGSPAASDD 2 4.297 0.407 GR.R 3 4.805 0.358 R.FSSHVGGTLGQFYQEVLWGSPAASDD 3 4.817 0.271 GRR.T R.GPDVLTATVSGK.L 1 2.389 0.247 2 3.574 0.398 R.HRQGPVNLLSDPEQGVEVTGQYER.E 3 5.669 0.435 R.HRQGPVNLLSDPEQGVEVTGQYEREK 3 4.832 0.344 .A R.LPEGSVSLIILLTDGDPTVGETNPR.S 2 5.645 0.386 R.LWAYLTIQQLLEQTVSASDADQQALR. 3 4.266 0.362 N R.MNFRPGVLSSR.Q 2 3.592 0.323 R.NRNVHSAGAAGSR.M 2 3.502 0.477 R.NVHSAGAAGSR.M 1 2.477 0.219 2 2.265 0.246 R.PSLVPASAENVNK.A 2 3.434 0.390 R.QGPVNLLSDPEQGVEVTGQYER.E 2 4.908 0.384 3 4.953 0.117 R.QGPVNLLSDPEQGVEVTGQYEREK.A 3 4.124 0.323 R.QLGLPGPPDVPDHAAYHPFR.R 2 3.665 0.429 R.RLDYQEGPPGVEISCWSVEL.- 2 2.947 0.187 R.SFAAGIQALGGTNINDAMLMAVQLLDS 2 3.826 0.280 SNQEER.L 3 6.266 0.414 R.VQGNDHSATR.E 2 2.915 0.396 S.ASDADQQALR.N 2 3.673 0.211 S.MVVTKPDDQEQSQVAEKPMEGESR.N 3 5.246 0.437 S.RQLGLPGPPDVPDHAAYHPFR.R 3 4.820 0.378 S.VAEQEAEFQSPK.Y 2 2.201 0.237 V.PAPIQAPSAILPLPGQSVER.L 2 2.379 0.322 W.KETLFSVMPGLK.M 2 3.940 0.345 Y.IFHNFMER.L 1 2.299 0.107 2 2.653 0.200 Homo sapiens PRO2266 mRNA, GP:AF119870_1 complete cds; predicted protein of A.ESRPVSLAGSTTKKM.L 1 2.527 0.108 G HQ2266. Homo sapiens methyl-CpG binding IPI:IPI00022481.1 GP:AF120999_1 protein 4 (MBD4) gene, exons 4a L.SSGSNFCSEQKTSGIINKF.C 2 3.010 0.189 A, O (97%) through 7 and complete cds. Homo sapiens isolate 89 immunoglobulin lambda light chain GP:AF121402_1 R.NNNRPSGISER.F 2 3.193 0.294 G, O, P variable region (IGL) gene, partial cds; IGLV. Homo sapiens isolate E6114 immunoglobulin lambda light chain GP:AF122008_1 D.VIKRPSGVPDR.F 2 2.930 0.229 P variable region (IGL) gene, partial cds; IGLV. Homo sapiens isolate 27 GP:AF123323_1 K.SGTSASLAISGXR.S 1 2.580 0.317 G, O, P immunoglobulin lambda light chain Supplementary Table 1 64 variable region (IGL) gene, partial cds; IGLV. 2 4.025 0.426 Homo sapiens isolate st449097 immunoglobulin lambda light chain GP:AF123338_1 K.XVHWYQQK.S 1 2.662 0.353 G variable region (IGL) gene, partial cds; IGLV. Homo sapiens clone APJL1 lambda 1 GP:AF124164_1 immunoglobin light chain variable -.QSVLTHPPSVSAAPGQK.V 2 2.692 0.172 O, P region mRNA, partial cds. Homo sapiens clone RWJL3 lambda 1 GP:AF124179_1 immunoglobin light chain variable -.SCELIQPPSVSVSPGQTAR.I 2 3.314 0.329 G, O region mRNA, partial cds. Homo sapiens clone NRDK1 lambda 1 GP:AF124194_1 immunoglobin light chain variable -.DIQMTQSPSSLSASIGDR.V 2 4.774 0.373 G, O region mRNA, partial cds. Homo sapiens Rab6-like protein gene, GP:AF124200_1 partial cds; similar to GTP-binding R.DSAAAVVVYDITNVNS.F 2 2.978 0.191 O protein; MDR-related protein. Homo sapiens SH2-containing protein GP:AF124251_1 M.FSFAAVMGALDMAQI.S 2 3.272 0.115 O, P Nsp3 mRNA, complete cds. R.RSVTMTDGLTADKVTR.S 2 2.410 0.196 Homo sapiens TRK-fused gene- anaplastic lymphoma kinase fusion protein (TFG/ALK) mRNA, complete IPI:IPI00018850.1 GP:AF125093_1 cds; polymorphic variant of TRK-fused K.DPEGVPPLLV.S 1 1.948 0.220 A, O (99%) gene/anaplastic lymphoma kinase presented in GenBank Accession Number AF143407. L.MAGGDLKSFLRETRPRPSQPSSLAML 3 3.715 0.154 DLLHVAR.D IPI:IPI00164336.1 GP:AF126028_1 Homo sapiens unknown mRNA. P.VDDPSLKVLVA.N 2 2.870 0.147 G (96%) Homo sapiens isolate 459 immunoglobulin lambda light chain GP:AF127125_1 K.TVHWYQQR.P 1 2.201 0.173 G variable region (IGL) gene, partial cds; IGLV. Homo sapiens immunoglobulin heavy GP:AF127792_1 chain variable region mRNA, partial K.NTVFLQMN.G 1 2.100 0.087 G cds; VH3-J4. Homo sapiens isolate 5001117 GP:AF128428_1 immunoglobulin lambda light chain N.IGSNTVNWYQKLPGTAPK.L 2 4.416 0.345 G, O, P variable region gene, partial cds. N.TVNWYQKLPGTAPK.L 2 3.331 0.192 N.WYQKLPGTAPK.L 2 2.950 0.172 S.NTVNWYQKLPGTAPK.L 2 4.215 0.356 Homo sapiens CDC42-binding protein V.QRGIGTAYKGHVKVPKPTGVKKGWQR IPI:IPI00005689.2 GP:AF128625_1 kinase beta (CDC42BPB) mRNA, 3 3.774 0.145 O AYAVVCE.C (95%) complete cds. Homo sapiens immunoglobulin heavy IPI:IPI00183390.1 GP:AF129753_1 chain variable region mRNA, partial -.EVQLVESGGGLVQPEGSLR.L 2 3.640 0.389 G, O (92%) cds. Q.LVESGGGLVQPEGSLR.L 2 3.645 0.340 Homo sapiens clone FLB9440 GP:AF130089_1 PRO2550 mRNA, complete cds; R.WSFTLVAQAGVQ.W 1 2.269 0.153 P predicted protein of HQ2550. Homo sapiens chromosome 16 open reading frame 5 (C16orf5) mRNA, GP:AF131218_1 I.GPPPYEPPG.H 1 2.278 0.117 G, P complete cds; novel proline rich gene; highly expressed in brain. W.SLSRSHLGLGAVPPSPR.S 2 2.296 0.107 Homo sapiens clone 24898 mRNA IPI:IPI00026327.1 GP:AF131744_1 G.SCSQLCGDSGTDAGADHPLVEIVL.D 2 3.093 0.159 G sequence, complete cds. (96%) Homo sapiens myosin X (MYO10) GP:AF132021_1 mRNA, partial cds; unconventional Y.RCSVGTYNSSGAYRFSSE.G 2 3.465 0.160 P myosin. Homo sapiens CGI-06 protein mRNA, IPI:IPI00100030.1 GP:AF132940_1 T.RWDSELQREGVSHYR.L 2 2.797 0.223 A complete cds. (96%) Homo sapiens CGI-26 protein mRNA, IPI:IPI00219677.1 GP:AF132960_1 I.VMLRAIRDFFWK.T 2 2.531 0.085 O complete cds. (96%) Mus musculus G7c (G7c) gene, G7c-b allele, complete cds; unknown function; corresponds to Mus V.SLEPVGPPVRGLLAASLPPTLLSVSSP. GP:AF134318_1 2 2.647 0.192 G musculus G7c mRNA sequence F presented in GenBank Accession Number AF134319; similar to Homo Supplementary Table 1 65 sapiens G7c protein encoded by GenBank Accession Number AJ245418. Homo sapiens immunoglobulin heavy GP:AF135164_1 chain precursor (IGH@) mRNA, partial Q.GTKVTVSSASTK.G 1 1.885 0.256 G cds. 2 2.662 0.237 Homo sapiens proteinx0005 mRNA, IPI:IPI00178564.1 GP:AF136978_1 T.AKGKPVLAK.D 1 1.939 0.170 P complete cds. (93%) Homo sapiens centrosomal P4.1- IPI:IPI00028166.1 GP:AF139625_1 associated protein (CPAP) mRNA, N.LFSEAQYQEAPV.E 1 2.138 0.124 A (97%) complete cds. Q.QLQRKTALKNKELCADNPILKKDSKAR 2 2.222 0.115 TK.S Homo sapiens APMCF1 (APMCF1) IPI:IPI00001620.2 GP:AF141882_1 L.NTLRVTRSAAPSTLYSSSTAPAQ.L 2 2.676 0.204 G, P mRNA, complete cds. (93%) R.LQFLERFKSSAGAI.V 1 2.001 0.121 Porphyromonas gingivalis strain W50 immunoreactive 47 kD antigen PG120 GP:AF144640_1 K.IKEYGLE.- 1 2.231 0.110 A gene, complete cds; reactive with sera from human periodontitis patients. Homo sapiens endoplasmic reticulum alpha-mannosidase I mRNA, complete IPI:IPI00008207.1 GP:AF145732_1 cds; Man9GlcNAc2-specific R.FTRVPSGGYSSINNVQDPQKPE.P 2 2.789 0.123 G (95%) processing alpha-mannosidase; glycoside hydrolase family 47. Homo sapiens antibody heavy chain GP:AF146402_1 variable region (EL-14) mRNA, partial R.QAPGQGLEWMGGIIPIFGSTKYAQK.F 2 3.302 0.247 G cds. Homo sapiens antibody light chain GP:AF146408_1 variable region (EL-16) mRNA, partial K.YNSAPWTFGQGTK.V 1 1.981 0.180 G cds. 2 3.294 0.403 Homo sapiens MIL1 protein mRNA, GP:AF146568_1 complete cds; nuclear gene for I.LAVAIGVALAL.R 1 2.166 0.126 A mitochondrial product. Homo sapiens filamin 2 (FLN2) IPI:IPI00178352.1 GP:AF146692_1 mRNA, complete cds; similar to filamin K.YVAPAHR.G 1 2.292 0.095 P (96%) 1 and beta-filamin; binds actin. Homo sapiens clone pAB196 FOXP1 GP:AF146697_1 R.NDKQPALQQQQ.V 1 1.845 0.111 G (FOXP1) mRNA, partial cds. Homo sapiens septin 10 mRNA, IPI:IPI00153055.1 GP:AF146760_1 A.ILKEAERELQAKF.E 2 2.652 0.119 O complete cds. (96%) Homo sapiens MYB-binding protein IPI:IPI00005024.1 GP:AF147709_1 1A (MYBBP1A) mRNA, complete cds; A.LPLLTKEQLHLVMQG.D 2 2.741 0.080 G, P (91%) P160. S.QVNGAPGSPTEPAGQKQHQKA.L 2 3.020 0.101 Homo sapiens BOG25 (BOG25) IPI:IPI00005030.1 GP:AF147747_1 P.NPAPVALQLWGKHQFVLSR.P 2 2.702 0.128 P mRNA, complete cds. (98%) Mus musculus serine protease mRNA, GP:AF148216_1 complete cds; similar to Homo sapiens K.VLNYVDWIK.K 2 2.645 0.185 O, P complement C1r. K.VLNYVDWIKK.E 2 3.120 0.297 R.GGGALLGDR.W 2 2.689 0.188 R.WILTAAHTIYPK.H 1 1.839 0.191 2 3.637 0.304 Drosophila melanogaster Su(z)12 GP:AF149047_1 mRNA, complete cds; similar to Homo S.KCSQIVYNPK.D 1 1.881 0.085 G sapiens KIAA0160. Homo sapiens WDR13 protein (WDR13) gene, complete cds; highly conserved novel member of WD family of proteins; widely expressed in GP:AF149817_1 A.GDDRGSVFSFLFDMATGKLTKAK.R 2 3.299 0.160 O various human tissues; similar to mRNA sequences found in GenBank Accession Numbers AF329819 and AF158978. Homo sapiens 3'-5' exonuclease TREX2 mRNA, complete cds; similar GP:AF151107_1 to the sequence presented in P.FTAKASEITGLSSEGLARCRKAGF.D 2 2.656 0.162 A GenBank Accession Number AF002998. Homo sapiens CGI-63 protein mRNA, IPI:IPI00107063.1 GP:AF151821_1 R.LKSLGAE.H 1 2.017 0.112 P complete cds. (93%) GP:AF151830_1 Homo sapiens CGI-72 protein mRNA, R.LNKITGLL.A 1 2.021 0.080 O IPI:IPI00006931.1 Supplementary Table 1 66 complete cds. (95%) Homo sapiens CGI-133 protein IPI:IPI00007045.2 GP:AF151891_1 D.LLEYGNQFQDALYK.M 2 2.611 0.172 A mRNA, complete cds. (97%) Homo sapiens protocadherin gamma A10 (PCDH-gamma-A10) mRNA, IPI:IPI00012546.1 GP:AF152319_1 A.VGEHTGEVRTARALLDR.D 1 1.934 0.153 A complete cds; member of the cadherin (96%) superfamily. Homo sapiens protocadherin gamma B1 (PCDH-gamma-B1) mRNA, IPI:IPI00031751.1 GP:AF152330_1 Y.FNVSLESG.D 1 2.399 0.132 O complete cds; member of the cadherin (98%) superfamily. Homo sapiens protocadherin gamma B3 (PCDH-gamma-B3) mRNA, IPI:IPI00012551.1 GP:AF152332_1 S.LRVLVDDRNDNA.P 2 2.666 0.092 G complete cds; member of the cadherin (99%) superfamily. Homo sapiens protocadherin gamma B2 short form protein (PCDH-gamma- IPI:IPI00215842.1 GP:AF152518_1 B2) variable region sequence, W.EQNTNHGAAGVPFASDTILKVS.F 2 3.404 0.127 G (96%) complete cds; member of the cadherin superfamily. Homo sapiens angiopoietin-related IPI:IPI00004957.1 GP:AF152562_1 protein 3 (ANGPTL3) mRNA, P.EHPEVTSLKTFVEK.Q 1 2.028 0.129 A (96%) complete cds. Homo sapiens chromosome 9 open F.VDYGVEALGEQALRRRRLLLLLGAGGP GP:AF153415_1 reading frame 5 mRNA, complete cds; 2 2.601 0.082 G, O, P L.L C9ORF5; CG2. P.WPIVGLGKF.L 1 2.156 0.159 Homo sapiens FERM-containing protein (CG1) mRNA, alternative IPI:IPI00152953.1 GP:AF153416_1 splice product, complete cds; I.QGGKEESPFVNINKK.S 1 2.594 0.092 G (92%) alternatively spliced; FERM family member. Porphyromonas gingivalis strain W50 immunoreactive 92 kDa antigen PG21 gene, complete cds; reactive with sera GP:AF153768_1 from human periodontitis patients and A.EDYIEVILDDSVE.D 1 2.248 0.179 G, O with sera from protected rats; C- terminus similar to Porphyromonas gingivalis cysteine proteases. L.KPTFLTPPSMQRAVEMFDYR.S 2 2.430 0.208 Homo sapiens brain protein (CG-6) R.PRQGGGGAGGSAAARARAGGLGGG. GP:AF155065_1 1 2.115 0.179 A mRNA, partial cds. S Homo sapiens Spacrcan mRNA, complete cds; hyaluronan-binding IPI:IPI00159771.1 GP:AF157624_1 K.VKDQLKVSPFLPD.A 2 2.654 0.143 O, P proteoglycan; interphotoreceptor (95%) matrix component. N.WWYRGKHCEEFVSEPVII.G 2 2.763 0.220 S.EVPGVDDYSVTKA.P 2 2.756 0.178 Homo sapiens clone 133K02 unknown IPI:IPI00032987.1 GP:AF159700_1 L.FHKTAALVLHGRK.Q 1 2.308 0.100 G mRNA; C5orf3. (96%) Homo sapiens HSPC081 mRNA, GP:AF161344_1 W.GSVCHYSGISTPHSWPNSPSL.G 3 4.086 0.110 O, P partial cds. Homo sapiens HSPC262 mRNA, GP:AF161380_1 D.GHLLEPDAEYLHWLLTNIPGNR.V 2 2.992 0.202 G, P partial cds. Y.LHWLLTNIPGNRVAEGQVTC.P 2 2.713 0.099 Homo sapiens HSPC279 mRNA, IPI:IPI00016847.2 GP:AF161397_1 C.YVDIPADFVNL.Q 1 2.099 0.098 A partial cds. (97%) Homo sapiens HSPC302 mRNA, GP:AF161420_1 V.IVIVGHVAKHTAEFAAH.L 2 2.401 0.126 G, O partial cds. V.IVIVGHVAKHTAEFAAHLVK.M 2 2.889 0.140 Homo sapiens HSPC127 mRNA, IPI:IPI00007426.1 GP:AF161476_1 K.RYPTTFVMVVM.L 1 2.211 0.174 P complete cds. (94%) Homo sapiens HSPC157 mRNA, GP:AF161506_1 V.INFNFQ.N 1 2.063 0.110 P complete cds. Homo sapiens HSPC167 mRNA, K.LRRLEELITIFREEASKANQTSVGCTQL. IPI:IPI00181645.1 GP:AF161516_1 2 2.542 0.138 P complete cds. V (98%) Homo sapiens HSPC057 mRNA, IPI:IPI00163318.1 GP:AF161542_1 I.RTFSAGKIKQFCK.T 2 2.514 0.107 G complete cds. (94%) Homo sapiens somatostatin receptor interacting protein splice variant a GP:AF163302_1 (SSTRIP) mRNA, complete cds; A.ARERALKESSEGGGAPQP.P 2 2.451 0.164 G, P multidomain postsynaptic density protein. Q.TISASESPGPGGLASLGKHRPKGF.F 2 2.592 0.176 GP:AF163306_1 Homo sapiens clone 3PC4 anti-HLA- R.ASHGINNYLAWYQQKPGK.A 2 2.834 0.106 G Supplementary Table 1 67 A2/A28 immunoglobulin light chain variable region mRNA, partial cds; VL region. Drosophila melanogaster FK506- binding protein FKBP59 (FKBP59) GP:AF163664_1 K.EKGTNYFKKENWALAIKM.Y 2 2.580 0.178 A mRNA, complete cds; similar to Homo sapiens and rabbit FKBP59. Homo sapiens cell division control IPI:IPI00001090.1 GP:AF164598_1 protein 16 (CDC16) mRNA, complete E.KQTAEETGLTPLETSRK.T 1 1.800 0.157 G (97%) cds; alternatively spliced. Homo sapiens clone 6B.1 immunoglobulin heavy chain variable GP:AF165100_1 region DP-54 mRNA, partial cds; H.GDFDYWGQGTLVTVSSASPTSPK.V 2 4.180 0.426 P Streptococcus pneumoniae type 6B specific Fab antibody. K.VFPLSLDSTPQD.G 2 3.133 0.340 Homo sapiens clone 23F.2 immunoglobulin kappa light chain IPI:IPI00178190.1 GP:AF165101_1 variable region A2 mRNA, partial cds; K.PGQPPQLLIYEVSNR.F 2 2.709 0.268 G (92%) Streptococcus pneumoniae type 23F specific Fab antibody. Homo sapiens clone 14.2 immunoglobulin heavy chain variable GP:AF165109_1 region LSG6.1 mRNA, partial cds; Q.DTVYLEMNSLK.T 1 2.369 0.134 G Streptococcus pneumoniae type 14 specific Fab antibody. Homo sapiens clone 14.4 immunoglobulin kappa light chain GP:AF165111_1 variable region L2 mRNA, partial cds; T.QSPATLSVSPGEGV.T 2 3.284 0.301 G Streptococcus pneumoniae type 14 specific Fab antibody. Homo sapiens immunoglobulin gamma1 heavy chain variable region GP:AF166264_1 mRNA, partial cds; rhFab HC45K W.WPYSFDYWGQGTLVTVSSASTK.G 2 3.643 0.259 G MS018; Fab fragment against human myelin basic protein. Homo sapiens ST7 protein (ST7) mRNA, complete cds; similar to low IPI:IPI00021027.1 GP:AF166350_1 K.IYDGLEEN.P 1 2.021 0.093 A density lipoprotein receptor-related (98%) protein 3 (LRP3). Homo sapiens clone Z3 IPI:IPI00007898.2 GP:AF167632_1 immunoglobulin heavy chain variable K.NTLYLQMNSMR.A 2 3.135 0.109 G (94%) region gene, partial cds. Homo sapiens clone A2.13 GP:AF167637_1 immunoglobulin heavy chain variable R.AEDTAVYYCAVLYS.S 2 3.480 0.178 G region gene, partial cds. Homo sapiens clone I2.1 IPI:IPI00184729.1 GP:AF167667_1 immunoglobulin heavy chain variable K.SKPDGGTTDYAAPVK.G 2 3.933 0.402 G (92%) region gene, partial cds. Homo sapiens clone case05H1 GP:AF168813_1 immunoglobulin heavy chain variable R.VTISVDMW.N 1 1.834 0.083 G region gene, partial cds. Homo sapiens clone case09H1 GP:AF168818_1 immunoglobulin heavy chain variable K.NTLYLQMNNLE.D 2 3.002 0.115 P region gene, partial cds. Homo sapiens protocadherin 13 (PCDH13) mRNA, partial cds; transmembrane protein of the IPI:IPI00171554.1 GP:AF169693_1 cadherin superfamily; contains only a S.PNAFLTK.L 1 1.981 0.087 A (96%) small cytoplasmic domain; putative alternative short form lacking the 3' exon sequences. V.LPSTLPGSPVTEVYAVDKDTGMNAVIA 2 2.501 0.162 YS.I Homo sapiens flavohemoprotein b5+b5R mRNA, complete cds; b5+b5R; cytochrome b-type NAD(P)H oxidoreductase; ubiquitously GP:AF169803_1 K.EPVLPNN.K 1 1.957 0.091 O expressed in human cell-lines and tissues a natural fusion of cytochrome b5 (b5) and cytochrome b5 reductase (b5R); corresponds to Hylobates lar SP100-HMG nuclear autoantigen (SP100) mRNA, partial IPI:IPI00218326.1 GP:AF169948_1 K.KRILKSHNNTLVDPCAVHKK.K 3 3.653 0.100 G, O cds; similar to Homo sapiens SP100- (94%) HMG; splice variant. GP:AF170071_1 Homo sapiens phospholipase C A.SISASILTTQNGEHNALEDLVMRF.N 2 2.919 0.104 O, P IPI:IPI00157968.1 Supplementary Table 1 68 epsilon mRNA, partial cds. (93%) Homo sapiens retinal degeneration B beta mRNA, complete cds; rdgB H.EQSDRGEGVEVVQNEPFEDPHHGNG IPI:IPI00063187.1 GP:AF171102_1 protein homolog; rdgBbeta; member of 3 3.902 0.172 O QFTEK.R (95%) the PITP family; phosphatidylinositol transfer protein. Mus musculus tumor-rejection antigen GP:AF172722_1 SART3 (Sart3) mRNA, complete cds; F.RYSTTLEKHKLFISGLPFSCTK.E 2 2.243 0.137 A similar to Homo sapiens SART3. R.AGKPKGLAYVEYENESQASQAVMKMD 3 3.644 0.150 GMTIRE.N Homo sapiens clone 77u-a01 immunoglobulin heavy chain variable GP:AF174005_1 K.MPGASVK.V 1 1.918 0.190 G, O region precursor (IgH) mRNA, partial cds. Y.MHWVQQAPGQGLEWMGWINPNSGG 3 3.574 0.186 AKYAQK.F Homo sapiens clone 77u-a11 immunoglobulin heavy chain variable GP:AF174014_1 A.GVQLVQSGAEVK.K 1 2.448 0.237 G region precursor (IgH) mRNA, partial cds. 2 3.461 0.300 Homo sapiens clone 77u-c06 immunoglobulin heavy chain variable IPI:IPI00220120.1 GP:AF174024_1 C.EVQLLESGGDLVQPGGSLR.L 2 3.625 0.435 G, O region precursor (IgH) mRNA, partial (94%) cds. G.LEWVSTISGSGTSVYYADSVK.G 2 2.945 0.190 Q.LLESGGDLVQPGGSLR.L 2 4.470 0.425 Homo sapiens clone 77u-c07 immunoglobulin heavy chain variable GP:AF174025_1 G.AHSQVQLVQSGAEVQ.K 2 4.828 0.403 G, P region precursor (IgH) mRNA, partial cds. Q.VQLVQSGAEVQ.K 2 3.093 0.251 Homo sapiens clone 77u-c26 immunoglobulin heavy chain variable IPI:IPI00182107.1 GP:AF174034_1 C.DVQLVESGGGLAQPGGSLR.L 2 4.192 0.265 G, O region precursor (IgH) mRNA, partial (94%) cds. Homo sapiens clone 77u-c27 immunoglobulin heavy chain variable GP:AF174035_1 S.QLQLQESGPR.L 2 3.407 0.233 G, O region precursor (IgH) mRNA, partial cds. Homo sapiens clone sc48u-27 GP:AF174051_1 immunoglobulin heavy chain variable R.LSISLDTSK.N 1 1.906 0.193 P region (IgH) mRNA, partial cds. Homo sapiens clone sc48u-28 GP:AF174052_1 immunoglobulin heavy chain variable Q.LVESGGGVVQPGK.S 2 2.790 0.255 O region (IgH) mRNA, partial cds. Homo sapiens clone sc48u-95 GP:AF174079_1 immunoglobulin heavy chain variable K.SIAYLQMDSLQ.T 1 2.797 0.331 G region (IgH) mRNA, partial cds. 2 3.158 0.175 Homo sapiens clone sc77u-04 IPI:IPI00180166.1 GP:AF174091_1 immunoglobulin heavy chain variable -.EVQLVQSGGGLVKPGGSLR.L 2 5.181 1.000 G, O (92%) region (IgH) mRNA, partial cds. Homo sapiens clone sc77u-22 GP:AF174104_1 immunoglobulin heavy chain variable -.EVQLVQSGGDLVQPGGSLR.L 1 2.770 0.297 G region (IgH) mRNA, partial cds. 2 3.099 0.294 Homo sapiens clone sc77u-26 GP:AF174106_1 immunoglobulin heavy chain variable -.EVQLVESGGSLIQPGGSLR.L 2 2.595 0.154 G region (IgH) mRNA, partial cds. Homo sapiens vacuolar sorting protein L.NLEHIATSSAVSKELTRLLKIPVDTYNNI IPI:IPI00018931.2 GP:AF175265_1 35 (VPS35) mRNA, complete cds; 3 4.088 0.360 P LTVLKLKH.F (94%) retromer protein; similar to MEM3. Porphyromonas gingivalis strain W50 immunoreactive 61kD antigen PG91 gene, complete cds; reactive with sera GP:AF175723_1 from human periodontitis patients, N.EYRLNVQHLAK.G 2 2.886 0.140 A sera from protected rats and sera from rabbits immunized with sarkosyl insoluble protein; C-terminal simila Homo sapiens ARTS protein (PNUTL2) mRNA, complete cds; IPI:IPI00183878.1 GP:AF176379_1 nuclear gene for mitochondrial P.FGHGYGPSLRLLAPPGA.V 2 2.760 0.164 G (98%) product; septin; contains P-loop GTP- binding domain similar to APAf-1 and Supplementary Table 1 69 CED-4. Xenopus laevis F-box protein 27 (Fbx27) mRNA, partial cds; similar to K.NKQKTSPRGPVTQAQTPPVDPKSIELT GP:AF176665_1 3 3.645 0.242 O human mitosin and CENP-F; interacts KCKAACEQ.Q with Skp1. Homo sapiens F-box protein FBX3 IPI:IPI00007299.1 GP:AF176702_1 R.IHNGQKLVVPGLLGSMALSNHYRS.E 2 2.516 0.198 O, P mRNA, partial cds. (96%) Homo sapiens low density lipoprotein receptor related protein-deleted in IPI:IPI00032063.1 GP:AF176832_1 D.GRSCKRPKNELFLFYGKGR.P 2 2.219 0.152 P tumor (LRPDIT) mRNA, complete cds; (94%) putative endocytic receptor. L.TKATALTIMDKKLWWADQNLA.Q 2 2.567 0.122 Homo sapiens mammalian inositol E.KTPKDWVRQHRKEEKMKSHKLEEEFE IPI:IPI00100543.1 GP:AF177145_1 hexakisphosphate kinase 2 (IP6K2) 3 4.118 0.294 A WLKKSEVLY.Y (94%) mRNA, complete cds; MIP6K2. Homo sapiens tropomodulin 4 GP:AF177173_1 V.RENATLTELRVDNQRQWPGDAV.E 2 2.791 0.106 O (TMOD4) mRNA, complete cds. Homo sapiens genethonin 3 mRNA, partial cds; striated muscle specific; similar to Caenorhabditis elegans IPI:IPI00007275.1 GP:AF177292_1 D.SEEMNINSVVTSADGENL.E 2 3.555 0.268 P UNC-89 protein sequence presented (98%) in GenBank Accession Number AAB00542. Homo sapiens clone SP220 unknown GP:AF177336_1 G.QLIAQGAIPPVXDFPXENPNDN.S 2 3.035 0.345 A, G mRNA. Homo sapiens polybromo-1 (PB1) mRNA, complete cds, alternatively GP:AF177387_1 I.SSVRFVPRDVPLPVVR.V 2 2.434 0.163 G, P spliced; contains six bromodomains; alternatively spliced. R.NLETAKKAEYE.G 2 3.003 0.161 Homo sapiens clone B22.9 IPI:IPI00007893.1 GP:AF177508_1 immunoglobulin heavy chain variable I.PILGIANYTQK.F 2 2.396 0.138 G (94%) region (IgH) gene, partial cds. R.IIPILGIANYTQK.F 2 3.189 0.121 Homo sapiens cone sodium-calcium IPI:IPI00218809.1 GP:AF177987_1 potassium exchanger splice variant I.EGAEAQTADEEE.D 1 2.198 0.132 G (93%) (NCKX) mRNA, complete cds. Mus musculus anti-human apolipoprotein A monoclonal antibody GP:AF178456_1 mAb(a)23L kappa light chain mRNA, K.YIAWYQHK.P 1 2.601 0.175 G partial cds; specific against human apolipoprotein A kringle V domain. Homo sapiens NOD2 protein (NOD2) mRNA, complete cds; contains two A.CQKLIAAAQEAQADSQSPKLHGCWDP IPI:IPI00005559.1 GP:AF178930_1 3 3.771 0.154 A, O CARD domains and LRRs; novel HSLHPARD.L (92%) member of NOD protein family. C.CWPDVGQEDIFQLLLDHPDRVLLTFDG 3 3.533 0.116 FDEFK.F Homo sapiens complement C1r-like IPI:IPI00009793.1 GP:AF178985_1 proteinase precursor, mRNA, G.SVLLAQELPQQLTSPGYPEPYGK.G 2 5.088 0.359 O, P (97%) complete cds. K.GQESSTDIKAPEGFAVR.L 2 2.326 0.206 R.GSEAINAPGDNPAK.V 2 3.716 0.263 R.VVVHPDYR.Q 2 2.424 0.123 Homo sapiens intersectin short form 2 K.RVASPAAKPVVSGEEIAQVIASYTAAGP IPI:IPI00220593.1 GP:AF180522_1 2 2.646 0.191 P (ITSN) mRNA, partial cds. E.Q (98%) Homo sapiens DAZ associated protein GP:AF181719_1 S.KSQAPGQPGASQWGSRVV.P 2 2.920 0.143 O 1 (DAZAP1) mRNA, complete cds. Homo sapiens heart/fetal otoferlin GP:AF183187_1 (OTOF) mRNA, complete cds; FER-1- K.WLIIKIVLALLGLLMLGLFL.Y 2 2.727 0.234 A like protein. Homo sapiens IgA1 heavy chain GP:AF184762_1 N.RQWGQGTLVTVSSASPTSPK.V 2 2.519 0.184 O mRNA, partial cds. Homo sapiens epidermal growth factor IPI:IPI00180489.1 GP:AF186084_1 repeat containing protein (EGFL6) K.SIIFEAERGKGKTGEIA.V 2 2.559 0.250 A, P (98%) mRNA, complete cds. P.QSNFCLLFDYRLAGDKVGK.L 2 2.823 0.083 Mus musculus dysferlin (Dysf) mRNA, complete cds; similar to Homo sapiens GP:AF188290_1 protein mutated in limb girdle D.LVPDTGGEEDTEDQGLTGDEAEPF.L 2 2.531 0.231 G, O muscular dystrophy type 2B or Miyoshi myopathy. S.AGARGYLKASLCVLGPGDEAPLDK.K 2 2.648 0.090 Homo sapiens clone 113SLE GP:AF188822_1 T.SNYPSWYQQTPGQAPR.T 2 2.930 0.270 G immunoglobulin lambda light chain Supplementary Table 1 70 variable region (IGLV8S1) gene, partial cds; antibody; immune response. Synthetic construct chimeric single chain fragment variable antibody 10B5 scFv mRNA, complete cds; chimeric single chain fragment variable (scFv) GP:AF189283_1 F.YPSDXAVEWESNGQPENNYK.T 2 4.745 0.511 A, G, O, P antibody fused to the human heavy chain immunoglobulin gamma 1 constant domains (CH1-CH3; A 6 His tag an G.FYPSDXAVEWESNGQPENNYK.T 2 2.359 0.204 K.GFYPSDXAVEWES.N 1 2.878 0.257 2 3.961 0.253 K.GFYPSDXAVEWESN.G 1 2.432 0.345 K.GFYPSDXAVEWESNGQPENNYK.T 2 5.031 0.454 K.GFYPSDXAVEWESNGQPENNYKTTPP 3 3.936 0.300 VLDSDGSFFLYSK.L S.NLHWYQQK.S 1 2.660 0.172 Y.PSDXAVEWESNGQPENNYK.T 2 4.429 0.459 Homo sapiens presenilin-associated protein mRNA, complete cds; PSAP; IPI:IPI00073111.1 GP:AF189289_1 S.QFSQALAIRSYTK.F 2 2.628 0.113 G, P PS-1 associated protein; PDZ-like (97%) protein. Homo sapiens serum albumin M.ADCCAKQEPESNECFLQHKDDNPNLP IPI:IPI00022434.1 GP:AF190168_1 3 4.570 0.306 A, O precursor, mRNA, complete cds. R.L (99%) Y.GEMADCCAKQEPESNECFLQHKDDNP 2 2.257 0.155 NLPR.L Homo sapiens anaphase-promoting IPI:IPI00178413.1 GP:AF191338_1 complex subunit 4 (APC4) mRNA, A.AALAPEIVIKVEKLDPEL.D 2 2.791 0.107 A (96%) complete cds. K.SLSVVTEVST.N 1 1.920 0.099 Homo sapiens immunoglobulin GP:AF191795_1 V.TISCSGSISNIGINSVYWYQQLPG.T 2 3.360 0.107 G lambda light chain gene, partial cds. Rattus norvegicus protein O- mannosyltransferase 1 (POMT1) mRNA, complete cds; similar to Homo GP:AF192388_1 sapiens POMT1, Drosophila R.LLNTHDVAAPLSPHSQ.E 1 2.698 0.148 A melanogaster rt (rotated abdomen), and yeast O-mannosyltransferases (PMTs). Homo sapiens Niemann-Pick C3 IPI:IPI00164155.1 GP:AF192522_1 protein (NPC3) mRNA, complete cds; V.NPALALEQK.R 2 2.612 0.124 O (94%) similar to Niemann-Pick C1 protein. Homo sapiens clone 11HC immunoglobulin heavy chain variable GP:AF193849_1 region mRNA, partial cds; Fab -.QVQLVQSGGGLVQPGGSLK.L 1 2.801 0.129 G monoclonal antibody against preS1 of hepatitis B virus. R.SEDTALYFCAKGGHV.A 2 2.536 0.179 Homo sapiens clone 3LC immunoglobulin light chain variable GP:AF193850_1 region mRNA, partial cds; Fab -.DIVMTQSPATLSLSPGER.A 2 3.519 0.345 G, O monoclonal antibody against preS1 of hepatitis B virus. Homo sapiens clone Z137K IPI:IPI00030205.1 GP:AF194122_1 immunoglobulin kappa light chain R.FSGSGSGTDFTLSISR.L 2 3.869 0.356 G (92%) variable region mRNA, partial cds. Homo sapiens clone 910 GP:AF194569_1 immunoglobulin lambda light chain K.LMIFEVSKRPSGVPDR.F 2 2.801 0.198 G variable region mRNA, partial cds. Homo sapiens clone 1515 GP:AF194594_1 immunoglobulin lambda light chain K.SGNTASLTISGLR.A 2 3.346 0.243 G variable region mRNA, partial cds. Homo sapiens clone 1338 GP:AF194647_1 immunoglobulin lambda light chain K.PGLSPVVVIYQ.D 1 2.430 0.122 G variable region mRNA, partial cds. Homo sapiens clone 1041 GP:AF194657_1 immunoglobulin lambda light chain S.YELTQPLSVSVALGQTAR.I 2 3.217 0.341 G, O variable region mRNA, partial cds. Homo sapiens clone 1202 IPI:IPI00186348.1 GP:AF194665_1 immunoglobulin lambda light chain S.YELTQQPSVSVSPGQTAR.I 2 2.862 0.165 O (95%) variable region mRNA, partial cds. Homo sapiens clone 1346 IPI:IPI00186348.1 GP:AF194677_1 K.SGQAPVLVIYEESK.R 2 4.162 0.351 G immunoglobulin lambda light chain (96%) Supplementary Table 1 71 variable region mRNA, partial cds. Homo sapiens clone 1405 IPI:IPI00186348.1 GP:AF194680_1 immunoglobulin lambda light chain K.EYAYWYQQK.S 1 3.104 0.216 G (96%) variable region mRNA, partial cds. Homo sapiens clone 1444 IPI:IPI00186348.1 GP:AF194685_1 immunoglobulin lambda light chain K.SGQAPVLVIYKGSK.R 2 3.035 0.228 G (94%) variable region mRNA, partial cds. Homo sapiens clone 1608 IPI:IPI00186348.1 GP:AF194692_1 immunoglobulin lambda light chain K.KHAYWYQQK.S 2 2.540 0.260 G (95%) variable region mRNA, partial cds. Homo sapiens clone 926 IPI:IPI00186348.1 GP:AF194710_1 immunoglobulin lambda light chain S.YELIQPPSVSVSPGQTAR.I 2 4.041 0.297 G, O, P (96%) variable region mRNA, partial cds. Homo sapiens clone 944 IPI:IPI00186348.1 GP:AF194711_1 immunoglobulin lambda light chain K.KYVYWYQQK.S 2 3.077 0.234 G (92%) variable region mRNA, partial cds. Homo sapiens clone 1137 GP:AF194722_1 immunoglobulin lambda light chain K.PGQAPALVIYGK.N 1 3.321 0.291 G variable region mRNA, partial cds. 2 4.392 0.303 Homo sapiens clone 1009 IPI:IPI00017248.1 GP:AF194781_1 immunoglobulin lambda light chain S.PGQAPLLVIYGK.N 2 3.906 0.148 G (93%) variable region mRNA, partial cds. Homo sapiens clone 1443 IPI:IPI00166489.1 GP:AF194792_1 immunoglobulin lambda light chain R.FSGSNSGNAATLTISR.V 2 3.357 0.431 G, O (92%) variable region mRNA, partial cds. Homo sapiens clone 1530 IPI:IPI00166489.1 GP:AF194795_1 immunoglobulin lambda light chain S.YVLTQPPSVSVAPGQMAR.I 2 2.822 0.316 P (92%) variable region mRNA, partial cds. Homo sapiens clone 1617 IPI:IPI00166489.1 GP:AF194799_1 immunoglobulin lambda light chain K.PGQAPVLVVYGDSDRPSGIPER.F 2 3.149 0.295 G (95%) variable region mRNA, partial cds. 3 3.570 0.428 Homo sapiens clone 718 GP:AF194801_1 immunoglobulin lambda light chain S.SVLTQPPSVSVAPGQTAR.I 2 3.264 0.297 G, O variable region mRNA, partial cds. Homo sapiens clone 1048 IPI:IPI00166489.1 GP:AF194804_1 immunoglobulin lambda light chain K.IVHWYQQK.P 1 2.681 0.303 G (95%) variable region mRNA, partial cds. Homo sapiens clone 1330 IPI:IPI00178482.1 GP:AF194808_1 immunoglobulin lambda light chain K.PGQAPVLIIYK.D 1 3.212 0.222 G (92%) variable region mRNA, partial cds. Homo sapiens clone 737 GP:AF194810_1 immunoglobulin lambda light chain -.SYELTQPPSVTVSPGQTAR.I 2 3.043 0.382 G, O variable region mRNA, partial cds. G.TYVFGGGTK.L 1 2.139 0.199 Homo sapiens DINP protein mRNA, IPI:IPI00218100.1 GP:AF194973_1 complete cds; similar to Escherichia P.GLVTKYSTSKKIK.P 2 2.600 0.130 P (99%) coli dinP. Homo sapiens clone 3/10/07 GP:AF195276_1 immunoglobulin V lambda/J lambda I.IYEVSDRPSGVSNR.F 2 2.489 0.120 G, O light chain gene, partial cds. Y.EVSDRPSGVSNR.F 2 2.926 0.215 Homo sapiens clone 27/10/07 GP:AF195288_1 immunoglobulin V lambda/J lambda G.SPGQSITISCAGTSSDVGGYNY.V 2 2.686 0.180 O light chain gene, partial cds. Homo sapiens clone 25/3/07 GP:AF195308_1 immunoglobulin V lambda/J lambda T.GSTLVLFGGGTK.- 1 2.191 0.138 G light chain gene, partial cds. Homo sapiens clone 12/11/06 GP:AF195333_1 immunoglobulin V lambda/J lambda L.TKPASVSGSPGQ.S 2 3.683 0.216 G light chain gene, partial cds. Homo sapiens clone mig GP:AF196473_1 immunoglobulin heavy chain variable L.IYWDDDTR.Y 2 2.622 0.180 G region gene, partial cds. Homo sapiens nocturnin (NOC) IPI:IPI00015890.1 GP:AF199493_1 A.KIPLIVCGDFNAE.P 1 2.219 0.082 G mRNA, partial cds. (99%) Homo sapiens splicing coactivator subunit SRm300 (SRM300) mRNA, GP:AF201422_1 L.VRESNNSRSQPQSRRRRKRR.K 2 2.667 0.099 P complete cds; Ser/Arg-related nuclear matrix protein. Homo sapiens p10-binding protein GP:AF202146_1 I.VTQNRVFAYLCKR.V 2 2.578 0.167 P BITE (BITE) mRNA, complete cds. Mus musculus ancient conserved IPI:IPI00006464.1 GP:AF202994_1 domain protein 1 (Acdp1) mRNA, Q.EEMPNFEEHRSQQVSLSPVAV.P 2 3.107 0.258 P (91%) complete cds; mACDP1; similar to Supplementary Table 1 72 Homo sapiens ACDP1. Megaderma lyra Brca1 (Brca1) gene, GP:AF203749_1 partial cds; similar to exon 11 of Homo K.SSTRHIHALELVSRN.P 2 3.818 0.099 A, G sapiens BRCA1. X.XXXXXXXXXXXXXSNPGNPEKECA.T 2 2.804 0.103 Homo sapiens organic anion transporter polypeptide-related protein IPI:IPI00008909.1 GP:AF205075_1 4 (OATPRP4) mRNA, complete cds; K.KENSSLYLAIMYV.M 2 2.542 0.177 G (93%) OATP-RP4; OATP transporter family member. Homo sapiens microfibrillar protein 2 GP:AF206020_1 mRNA, partial cds; contains Ig-like K.NYLAWYQQKPGQSPK.L 2 4.234 0.356 G, P domain. Homo sapiens BM-001 mRNA, R.ALQIPLPTRPHWFLLFGTTEEEIQEICIE GP:AF208843_1 3 3.535 0.121 A complete cds. TLRLYT.R Homo sapiens clone C3 immunoglobulin light chain variable IPI:IPI00024136.1 GP:AF209863_1 -.EIVMTQSPASLSLSPGER.A 2 2.501 0.212 O region mRNA, partial cds; anti- (91%) epithelial glycoprotein-2 antibody. Homo sapiens clone G5 immunoglobulin light chain variable IPI:IPI00024136.1 GP:AF209866_1 R.ASQSVSRYLAWYQQKPGQAPR.L 2 3.042 0.100 G region mRNA, partial cds; anti- (96%) epithelial glycoprotein-2 antibody. Homo sapiens immunoglobulin heavy GP:AF209889_1 chain variable region 194-88 mRNA, W.IDPNSGDTNYAQK.F 2 2.630 0.333 O partial cds. Homo sapiens immunoglobulin heavy IPI:IPI00018563.3 GP:AF209899_1 chain variable region 194-42 mRNA, K.GLEWMGIINPGDSDTR.Y 2 2.695 0.187 G (96%) partial cds. M.GIINPGDSDTR.Y 2 2.458 0.109 Homo sapiens immunoglobulin heavy GP:AF211930_1 chain variable region 194-4 mRNA, R.LEWMGWINAGNGDTK.Y 2 2.582 0.187 G partial cds. Homo sapiens ninein mRNA, GP:AF212162_1 R.RSLPEFQE.S 1 1.802 0.085 G, O, P complete cds. S.STLVSSLEAELSEVNYR.T 2 2.776 0.186 Homo sapiens CDA02 mRNA, IPI:IPI00012462.1 GP:AF212241_1 E.KVNIISVTNK.G 1 1.866 0.082 O complete cds. (93%) Homo sapiens isolate NT4 cyclin- IPI:IPI00003445.1 GP:AF213046_1 dependent kinase associated protein F.RDILAAHLSSR.D 1 2.281 0.225 P (99%) phosphatase mRNA, complete cds. Homo sapiens clone A34.1 IPI:IPI00218143.1 GP:AF216644_1 transmembrane protein vezatin A.KLQVTLKKYSVHLE.D 2 3.602 0.122 G (98%) mRNA, complete cds. Homo sapiens isolate 3 GP:AF216818_1 immunoglobulin heavy chain variable R.QAPGQGLEWMGGIIPLFGTANYAQK.F 2 2.683 0.172 G region gene, partial cds. Homo sapiens uncharacterized bone IPI:IPI00010278.3 GP:AF217523_1 marrow protein BM047 mRNA, Y.LRRSGGCTVTRRARSYL.C 2 2.871 0.131 O (97%) complete cds. Homo sapiens clone APAP2 IPI:IPI00020461.1 GP:AF217646_1 hypothetical protein mRNA, partial P.ESCSQTTSNVASQSMPPVYPSV.D 2 3.071 0.126 A, O (96%) cds; contains ten ankyrin repeats. Homo sapiens clone PP1143 GP:AF217969_1 K.LGPLAPSGSASWGQGSCL.G 1 1.967 0.107 G unknown mRNA. Homo sapiens clone PP213 unknown IPI:IPI00010181.1 GP:AF217999_1 K.IIEVEEEQEDPYLNDR.C 2 2.785 0.399 O, P mRNA. (99%) K.SQETGDLDVGGLQETDK.I 2 5.475 0.476 R.GYHLNEEGTR.C 2 2.531 0.267 R.ITYYHLSFPTNIQAPAVVFR.M 2 2.786 0.176 3 4.414 0.336 Homo sapiens islet-brain 2 mRNA, GP:AF218778_1 complete cds; IB2; JNK signaling A.GGAAQDSQDPEAAAGPGGV.E 2 2.684 0.092 O pathway scaffold. Homo sapiens uncharacterized A.GPDEDLSHRNKEPPAPAQQLQPQPVA GP:AF220188_1 hypothalamus protein HTMP mRNA, 3 3.506 0.098 P VQGPEPARVEK.I complete cds. Mus musculus Nedd4 WW domain- binding protein 1 mRNA, partial cds; N4WBP1; similar to human proline- GP:AF220205_1 S.GVHDAPPPPYSSLR.R 1 2.060 0.110 P rich Gla polypeptide 2 deposited under GenBank Acession Number AF009243. Homo sapiens Mam1 mRNA, partial GP:AF221759_1 G.DQQNGYGDLFPGHKK.T 2 2.528 0.129 G cds. Supplementary Table 1 73 Homo sapiens voltage-gated sodium channel alpha subunit splice variant GP:AF225986_1 G.VGGLGELLESSSEA.S 1 2.544 0.083 A SCN3A-s (SCN3A) mRNA, complete cds, alternatively spliced. Homo sapiens AD026 mRNA, GP:AF226731_1 L.ANDFWSGKDLSGNKTR.S 2 3.103 0.080 O, P complete cds. Homo sapiens candidate taste receptor T2R4 gene, complete cds; G IPI:IPI00027213.1 GP:AF227131_1 protein-coupled receptor; PCR-derived S.SLQFIINVTSASL.L 2 2.754 0.100 G (95%) sequence; similar to an interval in PAC AC004979. Homo sapiens candidate taste receptor T2R7 gene, complete cds; G IPI:IPI00028328.1 GP:AF227133_1 protein-coupled receptor; PCR-derived L.MSFFLLILSLRRHIR.R 2 3.083 0.087 A (94%) sequence; similar to an interval in BAC AC006518. Homo sapiens candidate taste receptor T2R10 gene, complete cds; GP:AF227136_1 G protein-coupled receptor; PCR- K.ILNDYKTK.N 1 2.331 0.135 P derived sequence; similar to an interval in BAC AC006518. Homo sapiens RPGR-interacting IPI:IPI00179169.1 GP:AF227257_1 protein-1 (RPGRIP1) mRNA, complete S.EQLKDVAYGTRPLSLCLETLPA.H 2 2.881 0.106 G (96%) cds. Homo sapiens HBV pX associated protein-8 mRNA, complete cds; novel GP:AF227948_1 T.EKLKNDQQAKIPLKK.R 2 3.175 0.100 A, O transcription coactivator; interacts with HB. V.KLEKPLPENEEK.K 2 2.978 0.098 Homo sapiens clone SCO GP:AF228320_1 immunoglobulin light chain variable -.DILMTQSPDSLAVSLGER.A 2 3.539 0.189 G, P region gene, partial cds; unmutated. T.SSQSILYSSNNK.N 2 2.627 0.279 Homo sapiens clone BARG GP:AF228321_1 immunoglobulin light chain variable -.EIVLTQSPATLSVSPGER.A 1 2.226 0.210 G, O, P region gene, partial cds; unmutated. 2 4.049 0.315 I.VLTQSPATLSVSPGER.A 2 2.807 0.319 R.ASQSVYSNLAWYQQK.P 2 3.251 0.321 Homo sapiens clone BARA IPI:IPI00161229.1 GP:AF228322_1 immunoglobulin light chain variable -.DILMTQSPSSLSA.S 2 3.157 0.249 G (96%) region gene, partial cds; unmutated. Homo sapiens clone BARM GP:AF228325_1 immunoglobulin light chain variable -.DILMTQSPASLSASVGDRV.T 2 2.877 0.096 G region gene, partial cds; unmutated. Homo sapiens clone CAZ IPI:IPI00030206.1 GP:AF228328_1 immunoglobulin light chain variable E.IVLTKSPGTLSLSPGER.A 2 4.531 0.321 A, G, O, P (92%) region gene, partial cds; unmutated. G.EIVLTKSPGTL.S 1 2.840 0.126 2 2.632 0.126 G.EIVLTKSPGTLSL.S 1 2.056 0.179 2 4.184 0.207 G.EIVLTKSPGTLSLSPGER.A 1 3.442 0.367 2 5.471 0.411 3 4.090 0.240 T.KSPGTLSLSPGER.A 2 2.934 0.339 Homo sapiens clone FAU GP:AF228330_1 immunoglobulin light chain variable A.HSDGNTYLNWFQQR.P 2 2.336 0.330 G region gene, partial cds; unmutated. R.FSGSGSATDFTLK.I 2 3.382 0.269 R.SNQSLAHSDGNTYLNWFQQR.P 2 3.478 0.311 Homo sapiens homeobox protein GP:AF229631_1 NKX2-3 gene, exon 2 and partial cds; A.AAEGTQFSDGGEEDE.E 2 3.036 0.087 P transcription factor. Homo sapiens protocadherin Fat 2 L.DSSYNLRVGASDGVFRATVPVYINTTN IPI:IPI00033803.1 GP:AF231022_1 (FAT2) mRNA, complete cds; member 2 2.456 0.202 G, P A.N (99%) of the cadherin superfamily. L.SASVRLHIEWIPW.P 2 2.542 0.188 Homo sapiens protocadherin Flamingo 1 (FMI1) mRNA, complete GP:AF231023_1 E.NARITYLLEDNLPQFRIDADSGAITL.Q 3 4.154 0.167 O, P cds; member of the cadherin superfamily. F.GSRDALDLGA.P 1 2.651 0.080
Supplementary Table 1 74 G.SHARCRCSRTGTFGVLMDASPR.E 2 2.303 0.113 Homo sapiens HES-related repressor P.ALRAPPSGSFGPVLPVVTSASKLSLPLL GP:AF232239_1 protein 2 HERP2 mRNA, complete 2 2.805 0.146 O SSVASLSAF.P cds; transcription factor. Homo sapiens clone BL135 IPI:IPI00030205.1 GP:AF233251_1 immunoglobulin light chain variable -.EIVLTQSPDTL.S 1 2.544 0.129 G, O, P (95%) region mRNA, partial cds. 2 3.587 0.227 -.EIVLTQSPDTLSLSPGER.A 2 4.621 0.377 A.SQSVNSSYLAWYQQKPGQ.A 2 3.427 0.157 I.VLTQSPDTLSLSPGER.A 2 2.318 0.259 Homo sapiens clone BL79 GP:AF233260_1 immunoglobulin light chain variable -.DIQMTQSQSSLSASVGDR.V 2 4.122 0.153 G, O, P region mRNA, partial cds. Drosophila melanogaster RECQ4 (RECQ4) gene, complete cds; DNA/RNA helicase; member of RECQ GP:AF233659_1 helicase family; similar to Homo A.VEASLSQ.P 1 2.160 0.124 P sapiens RecQ4, whose mutation is known to cause Rothmund-Thomson syndrome. W.CISVLSSAYVMAKVISYGGPKYLKHAA 3 3.952 0.253 KE.C Homo sapiens clone KM35 GP:AF234248_1 immunoglobulin heavy chain variable -.EVQLVESGGDLVEPGGSLR.L 1 2.158 0.144 G, O, P region mRNA, partial cds. 2 5.540 0.443 Homo sapiens clone KM38 GP:AF234251_1 immunoglobulin heavy chain variable Y.DGSSKYYADSVK.G 2 3.168 0.184 G region mRNA, partial cds. Homo sapiens clone KM38 GP:AF234257_1 immunoglobulin light chain variable -.DVEMTQSPSTLSA.S 2 3.224 0.270 G region mRNA, partial cds. Homo sapiens FLAMINGO 1 mRNA, partial cds; FMI; brain-specific, cadherin-like protein; similar to the Homo sapiens product encoded by IPI:IPI00015346.1 GP:AF234887_1 T.GVPLPTPPPPLLLLLLLLL.P 2 3.006 0.162 G clone KIAA0279 in GenBank (91%) Accession Number D87469 and Rattus norvegicus MEGF2 encoded by GenBank Accession Number AB Homo sapiens clone a22a24 immunoglobulin heavy chain variable GP:AF235587_1 R.AEDTAVYYCASIMAYWGQ.- 2 2.661 0.096 G region gene, partial cds; VH gene family 3; mutated. Homo sapiens clone c14a15 immunoglobulin heavy chain variable GP:AF235648_1 T.DASTSTAYMELR.S 2 2.747 0.298 G region gene, partial cds; VH gene family 1; mutated. Homo sapiens clone d1a10 immunoglobulin heavy chain variable GP:AF235786_1 T.YYADPVK.D 1 2.367 0.157 G region gene, partial cds; VH gene family 3, mutated. Homo sapiens clone d4a16 immunoglobulin heavy chain variable GP:AF235849_1 R.AEDTAVYYCAKDQYQLLVQD.N 2 2.690 0.132 G region gene, partial cds; VH gene family 3, unmutated. Homo sapiens clone d6a16 immunoglobulin heavy chain variable GP:AF235870_1 N.EDGSETYYVDSVK.G 2 3.437 0.347 G region gene, partial cds; VH gene family 3, mutated. Homo sapiens clone d6a18 immunoglobulin heavy chain variable GP:AF235871_1 H.VTLSADK.S 1 1.867 0.217 G region gene, partial cds; VH gene family 5, mutated. Q.GHVTLSADK.S 1 2.173 0.294 R.IDPSDSYTDYSPSFQGH.V 2 3.036 0.399 R.IDPSDSYTDYSPSFQGHVT.L 2 4.634 0.467 Homo sapiens clone d6a21 immunoglobulin heavy chain variable IPI:IPI00220120.1 GP:AF235874_1 R.AEDTAVYYCAKDTLGSTYA.F 2 3.284 0.096 G region gene, partial cds; VH gene (98%) family 3, unmutated. Porphyromonas gingivalis hypothetical GP:AF237557_1 tonB-linked outer membrane receptor A.QTVVTGKVIDSETSEPLI.G 2 2.608 0.136 O PG47 gene, complete cds; reactive Supplementary Table 1 75 with sera from human periodontitis patients and sera from rabbits immunized with sarkosyl insoluble Porphyromonas gingivalis protein. Homo sapiens recombinant IgG2 IPI:IPI00004608.1 GP:AF237584_1 C.PPCPAPPVAGPSVFLFPPKPK.D 2 2.343 0.106 G heavy chain gene, partial cds. (95%) C.VVVDVSHEDPEVQ.F 2 3.256 0.335 P.VAGPSVFLFPPKPK.D 2 3.226 0.345 R.TPEVTCVVVDVSHEDPEVQ.F 2 4.942 0.347 Homo sapiens Hodgkin's case 10 immunoglobulin heavy chain variable GP:AF237829_1 L.LMNDLRGDDSAVYFCV.R 1 2.607 0.146 O region gene, partial cds; VH gene family 3. Homo sapiens histone deacetylase 7 (HDAC7) mRNA, complete cds; HDA1 IPI:IPI00025451.1 GP:AF239243_1 R.AQSSPAAPASLSAPE.P 2 2.853 0.164 A class II; associated with (91%) rhabdomyosarcoma. Homo sapiens eIF4E-transporter GP:AF240775_1 mRNA, complete cds; A.KVDLKPLLSSLSANKEK.L 2 2.716 0.101 A, P nucleocytoplasmic shuttling protein. K.ELPHSKQRPSCLSE.K 1 2.196 0.116 Homo sapiens intrinsic factor-vitamin IPI:IPI00160130.1 GP:AF243129_1 B12 receptor (CUBN) gene, exon 67 H.GRILEMDIEEIQNCYYDK.L 2 2.316 0.170 A, G (99%) and partial cds; cubilin. T.FISPNYPMPY.Y 1 2.301 0.108 Homo sapiens beta-2 syntrophin mRNA, complete cds, alternatively GP:AF243385_1 spliced; 28 kDa; alternatively spliced; L.RLGDAILSVNGTDLRQATHDQAVQ.A 2 2.404 0.129 A, P lacks exon 3; contains PH1a, PDZ and PH1b domains. R.KIIPLKMCFAARNLSMPDLEN.R 2 3.281 0.195 Homo sapiens WDR10p (WDR10) mRNA, alternatively spliced, complete IPI:IPI00180645.1 GP:AF244930_1 F.KEAYQIACLGVTDTDW.R 1 2.068 0.098 G cds; WD repeat protein; 7 WD (96%) repeats; alternatively spliced. Homo sapiens IgA heavy chain GP:AF245311_1 G.VRVTVSSASPTSPK.V 1 2.107 0.362 A, O, P variable region mRNA, partial cds. 2 4.236 0.170 Homo sapiens NGT mRNA, complete IPI:IPI00184230.1 GP:AF247166_1 Q.VFGTTGK.F 1 1.918 0.133 G cds. (93%) Homo sapiens golgi matrix protein GM130 (GOLGA2) mRNA, complete GP:AF248953_1 K.KKKIKNGSNPETT.T 2 2.513 0.131 P cds; similar to Rattus norvegicus GM130; similar to golgin-95. Homo sapiens GAP-like protein (N61) GP:AF251038_1 mRNA, complete cds; contains two D.LNANTESEVPGGQSVGVQG.E 2 3.565 0.234 O bipartite nuclear localization signals. P.SLSNCNSVLANKIFGIPLDEL.Q 2 2.934 0.137 Homo sapiens calcyphosine mRNA, IPI:IPI00170960.1 GP:AF251056_1 N.TLLKLRITNIDQIALDSLK.T 2 2.279 0.120 A, G complete cds. (99%) S.LTIYEYRQFGKNR.T 1 2.193 0.227 Homo sapiens DC29 mRNA, complete R.KVFGGALSLRCIGLSRPTSSSLGGPAT GP:AF255647_1 2 2.549 0.095 G cds. P.G Homo sapiens DC28 mRNA, complete IPI:IPI00185215.1 GP:AF255649_1 A.LKMTREER.I 2 2.513 0.093 P cds. (97%) Homo sapiens two pore potassium channel KT3.3 mRNA, complete cds; GP:AF257081_1 L.GFSPPSSPGVVRGGQA.P 2 2.744 0.100 P leak channel; phylogenetically similar to TASK1. Homo sapiens ASH1 mRNA, complete GP:AF257305_1 I.RSNVYVDVKPL.S 1 2.582 0.113 G cds; huASH1. Homo sapiens betaine-homocysteine A.KKGILERLESGEVVIGDGSFLITLEKRG. IPI:IPI00014363.1 GP:AF257473_1 methyltransferase 2 (BHMT2) mRNA, 3 3.767 0.240 O Y (96%) complete cds. Homo sapiens MER receptor tyrosine IPI:IPI00183482.1 GP:AF260529_1 kinase (MERTK) gene, exon 19 and V.KFNCSISVPNIYQ.D 1 2.541 0.089 G (96%) partial cds. Homo sapiens eIF-5A2 mRNA, GP:AF262027_1 complete cds; member of eIF-5A S.VMCAMSEEYAVA.I 1 2.042 0.137 P family. Homo sapiens clone cp2-017 GP:AF262085_1 immunoglobulin heavy chain variable R.VTISIDTSE.N 1 1.906 0.080 G region mRNA, partial cds. Homo sapiens clone cp2-020 GP:AF262088_1 R.VSMSIDTSK.N 1 1.866 0.180 G immunoglobulin heavy chain variable Supplementary Table 1 76 region mRNA, partial cds. Homo sapiens clone cp2-050 GP:AF262118_1 immunoglobulin heavy chain variable R.VTISADTSK.N 1 1.874 0.273 G, P region mRNA, partial cds. Homo sapiens clone cp2-hb3 GP:AF262144_1 immunoglobulin heavy chain variable Q.GTTVIVSSAPTK.A 1 1.839 0.148 G region mRNA, partial cds. Homo sapiens clone cp1-007 R.QPPGKGLEWIGEINHSGTTINNPSLKS GP:AF262151_1 immunoglobulin heavy chain variable 3 4.014 0.249 O RVTTS.V region mRNA, partial cds. Homo sapiens clone cp1-055 GP:AF262199_1 immunoglobulin heavy chain variable Q.GTLVTVSSAPTK.A 1 1.968 0.278 G region mRNA, partial cds. Entamoeba histolytica putative iron hydrogenase HydA mRNA, partial cds; F.TQEREEALAKTEDGQCDLPFRRISGGS GP:AF262400_1 3 3.870 0.135 G, O, P similar to Homo sapiens NARF and NIFGRTGGVC.E Kluveromyces LET1. M.CATKCTFGVLVKQPPKIPPFVQPNREK 3 3.556 0.141 LSQENTDK.T V.VEMMACVGGCLGGAGQPKIPPAKK.L 2 2.538 0.162 Mus musculus anti human TNF-alpha GP:AF262753_1 light chain variable region gene, partial L.AWYQKKPGQ.S 1 2.341 1.000 G cds. N.YLAWYQKK.P 1 2.472 0.125 2 2.722 0.250 N.YLAWYQKKPGQ.S 2 3.187 1.000 Q.KNYLAWYQKK.P 2 3.289 0.223 Y.LAWYQKK.P 1 2.135 0.095 Y.LAWYQKKPGQ.S 1 2.674 1.000 Mus musculus PALML mRNA, GP:AF263246_1 complete cds; similar to Homo sapiens K.KLLTGYDGVIHAELVVIDDEA.E 2 2.686 0.193 P PALML. Homo sapiens rab3 interacting protein variant 1 mRNA, partial cds; RIM; alternatively spliced; similar to Homo sapiens sequence deposited in GP:AF263305_1 G.TVGAGGKK.R 1 2.054 0.086 O GenBank Accession Number AL035633; similar to Homo sapiens KIAAO340 encoded by GenBank Accession Number AB002 Homo sapiens disabled-1 (DAB1) mRNA, complete cds; similar to GP:AF263547_1 V.QQQMVMGAQPPVAQ.V 1 2.409 0.168 G Disabled protein of Drosophila melanogaster. Homo sapiens ALR-like protein mRNA, complete cds; similar to IPI:IPI00220781.1 GP:AF264750_1 K.IPELGGKDVEDL.F 2 3.330 0.105 P sequence deposited in GenBank (99%) Accession Number AC006017. Homo sapiens clone IgA5741-27 immunoglobulin A heavy chain mRNA, GP:AF267102_1 -.AEDTAVYYCVTGSASGSSR.Y 2 2.771 0.082 G partial cds; IgA VH; VDJ rearrangement; CDR3 region. -.AEDTAVYYCVTGSASGSSRYFDF.W 2 2.698 0.132 Arabidopsis thaliana nuclear cap- binding protein CBP80 mRNA, GP:AF268377_1 L.YGTLIGLLNLENEDFVQK.L 2 2.892 0.147 A, P complete cds; similar to Homo sapiens CBP80. R.ISDLRKDISNITKNVLVAEK.A 2 2.951 0.183 Homo sapiens breast cancer antigen NY-BR-1.1 mRNA, partial cds; similar IPI:IPI00071884.1 GP:AF269088_1 to breast cancer antigen NY-BR-1 with I.HQQLLEHIRKLPKNPQNT.N 2 2.757 0.123 G, O, P (91%) GenBank Accession Number AF269087. L.LAIQKRSKQTVEFLLTKNANA.N 2 2.455 0.189 Homo sapiens lysosomal apyrase-like IPI:IPI00006476.1 GP:AF269255_1 protein 1 (LALP1) mRNA, complete V.KKHKETPLYILCTAGMRLLPER.K 2 2.347 0.142 G, P (94%) cds. Y.EDLVLNETLNK.N 1 2.814 0.081 Homo sapiens translational repressor pumilio (PUM2) mRNA, partial cds; interacts with the DAZ protein in the IPI:IPI00022184.1 GP:AF272350_1 RNA-binding region; mRNA is L.ALATRIRGHVLPLALQMYG.C 2 2.401 0.129 O (95%) predominantly expressed in the testis and ovaries; similar to Drosophila Pumilio, which is involved in Supplementary Table 1 77 embryogene L.GAPVRLMAPTPVLISSAAAQAAAA.A 2 2.648 0.088 Homo sapiens CTCL tumor antigen IPI:IPI00178799.1 GP:AF273049_1 L.NQQMFNSDLEK.K 2 3.129 0.127 O se33-1 mRNA, complete cds. (99%) Homo sapiens actin binding protein anillin mRNA, complete cds; cleavage furrow component; involved in IPI:IPI00032958.1 GP:AF273437_1 N.SVQEQPGTACLSKFSSASGASARI.N 2 2.601 0.119 P cytokinesis; similar to actin binding (91%) protein anillin in Drosophila melanogaster. R.RRWDNDDMTDDIPESSL.F 2 2.524 0.090 Homo sapiens nuclear zinc finger protein Np95 (UHRF1) mRNA, complete cds; overexpressed in IPI:IPI00066641.1 GP:AF274048_1 leukemic cell lines; expression A.RELYANVVLGDDSLNDCRIIFV.D 2 2.525 0.125 A, G (94%) detected only in dividing cells, with maximum expression during S-phase of cell cycle. T.NMGAWFEAQVVR.V 1 2.515 0.114 Xenopus laevis microtubule associated protein XMAP215 isoform M mRNA, complete cds; alternatively spliced; XMAP215M; regulates GP:AF274063_1 A.VENKEIIEQE.L 2 2.472 0.110 O, P microtubule elongation and dynamics; maternally expressed transcript; similar to Homo sapiens ch-TOG deposited in GenBank A L.VDKVGDVKCGGNAKE.A 2 2.405 0.101 V.VLDGLVDKVGDVKCGGNAKEALS.G 2 2.477 0.124 Homo sapiens PR-domain containing protein 8 (PRDM8) mRNA, complete GP:AF275815_1 T.SVYTTCDIPENAIFGPCVLSHTSL.Y 2 3.022 0.234 G cds; PFM5; contains zinc fingers; PR- domain family member 5. Mus musculus VPS10 domain receptor (SorCS3) mRNA, complete GP:AF276314_1 K.SIFSRRCTKEDFETWHLLNQG.E 2 2.915 0.096 A cds; contains VPS10 domain; similar to Homo sapiens KIAA1059 protein. Homo sapiens PNAS-126 mRNA, complete cds; NB4 GP:AF277184_1 L.QPLNLPYFVSVLLICC.C 2 2.609 0.147 G apoptosis/differentiation related protein. Homo sapiens vitamin D receptor- interacting protein complex IPI:IPI00219430.1 GP:AF277379_1 A.LLSALHWLL.R 1 2.487 0.251 O, P component DRIP100 (DRIP100) (95%) mRNA, complete cds. D.CTNFLLQECGK.Q 2 2.708 0.145 N.IKGKVCSLAVCAVAWLVAHVR.M 2 2.306 0.239 Homo sapiens sialic acid-binding immunoglobulin-like lectin-like splice IPI:IPI00071204.2 GP:AF277806_1 variants (SLG) gene, complete cds, V.SRNIPVATNNPARAVQEETRDRFHLL.G 2 2.579 0.107 A, O (93%) alternatively spliced; SLG-L; SIGLEC- like. Y.PHYNWTASSPVYGSWFK.E 2 2.696 0.100 Homo sapiens kappa B and V(D)J recombination signal sequences GP:AF278765_1 binding protein (KRC) mRNA, P.GPSDAARNLPLESTK.S 2 2.566 0.146 P complete cds; zinc finger transcription regulator KRC. Homo sapiens kinesin-like protein GAKIN mRNA, complete cds; G.DRLKEGSNINESLTTLGLVISALADQSA IPI:IPI00021753.1 GP:AF279865_1 associates with the human homolog of 3 3.859 0.221 P GKNKNKFV.P (91%) the Drosophila discs large tumor suppressor in T lymphocytes. Homo sapiens inner centromere IPI:IPI00179857.1 GP:AF282265_1 protein INCENP mRNA, complete cds; K.SKARILESITVS.S 1 2.258 0.133 G (94%) chromosomal passenger. Homo sapiens heparanase-like protein IPI:IPI00157364.1 GP:AF282887_1 HPA2c mRNA, complete cds; splice L.IGPKVLAVHVAGLQRKPRPGR.V 2 2.201 0.164 A (99%) variant. W.NSSSALSLLKYSASK.K 2 2.670 0.117 Homo sapiens clone TCBAP0758 GP:AF283769_1 mRNA sequence; similar to GenBank A.SQPSLVSTVAPGSGLAPTAQPGAP.S 2 2.715 0.172 G, P Accession Number AC021163. L.EWQEKPKPASVD.A 2 2.709 0.083 GP:AF283789_1 Homo sapiens isolate B-DLCL0010 C.QVQLVEAGGGVVQPGK.S 2 3.281 0.245 G, O Supplementary Table 1 78 clone 10 immunoglobulin heavy chain variable region mRNA, partial cds. Homo sapiens isolate B-DLCL0026 GP:AF283791_1 clone 1 immunoglobulin heavy chain C.QEELVQSGGGLVK.P 2 3.245 0.122 O, P variable region mRNA, partial cds. Homo sapiens isolate B-DLCL0010 GP:AF283797_1 clone 7 immunoglobulin heavy chain C.EVQLLDSGGGLVQPGGSLR.L 1 3.229 0.103 G, P variable region mRNA, partial cds. 2 2.829 0.176 L.LDSGGGLVQPGGSLR.L 1 2.585 0.191 Q.LLDSGGGLVQPGGSLR.L 1 2.403 0.155 2 3.535 0.080 Homo sapiens isolate B-DLCL0013 IPI:IPI00220120.1 GP:AF283805_1 clone 2 immunoglobulin heavy chain C.EAQLLESGGGLVQPGGSLR.L 2 2.788 0.220 G (94%) variable region mRNA, partial cds. Homo sapiens isolate B-DLCL0004 GP:AF283806_1 clone 1 immunoglobulin heavy chain R.LEWMGWINAGNGNTE.Y 2 2.625 0.231 G variable region mRNA, partial cds. Dasypus novemcinctus BRCA1 gene, GP:AF283999_1 partial cds; similar to Homo sapiens T.ELQIDSCSSIEEI.E 2 3.658 0.148 O BRCA1 gene exon 11. Glaucomys volans BRCA1 gene, GP:AF284003_1 partial cds; similar to Homo sapiens A.GILEIPNEVDGFSGSSEKIDLLA.T 2 2.739 0.130 A BRCA1 gene exon 11. P.GLKLTGISGI.F 1 2.090 0.172 Elephantulus rufescens BRCA1 gene, GP:AF284028_1 partial cds; similar to Homo sapiens L.DTQYLQHTFKVSKRQSFSLF.P 2 3.013 0.205 O, P BRCA1 gene exon 11. Homo sapiens HT036-ISO (HT036- GP:AF284750_1 R.IHLMAGR.V 1 2.280 0.166 O, P ISO) mRNA, complete cds. Homo sapiens testis protein TEX15 IPI:IPI00010369.1 GP:AF285605_1 L.NVNFKK.Q 1 2.229 0.121 O, P (TEX15) mRNA, complete cds. (95%) Ustilago maydis regulator Ustilago maydis 1 protein (rum1) gene, GP:AF286030_1 complete cds; similar to Homo sapiens D.PPTNGLAR.R 1 2.038 0.125 O, P retinoblastoma binding protein 2; Rum1. Q.ENGVKHPSMSPSLDAAPSGDAGEHFK 2 2.465 0.140 TPEPFTAAGA.A Homo sapiens guanylate binding GP:AF288814_1 protein 4 mRNA, complete cds; GBP4; M.KEAAEKEQELLREK.Q 3 3.516 0.115 P IFN-gamma-indicible. Drosophila melanogaster lilliputian mRNA, complete cds; novel transcription regulator; contains an I.VKNEKNDMAMEEGEEEDDDEEQQLRY GP:AF289034_1 HMG1 (AT-hook) motif and a domain 3 3.770 0.145 G GGGLS.V similar to the human fragile X mental retardation 2 (FMR2) gene and the AF4 protooncogene. Homo sapiens interleukin-4 induced gene-1 protein (FIG1) gene, exons 5 GP:AF293463_2 through 8 and partial cds; and E.LTMKLSVEDVLTRAEALHRQLTA.C 2 2.840 0.294 A, O, P GTPase-activating protein-like protein FLJ12168 gene, partial cds. Macaca mulatta aryl-hydrocarbon interacting protein-like 1 (Aipl1) IPI:IPI00166974.1 GP:AF296411_1 R.QVDQPMHIIIGNMFKL.E 1 1.962 0.107 G mRNA, complete cds; similar to Homo (98%) sapiens AIPL. Homo sapiens toll-like receptor 10 IPI:IPI00008887.1 GP:AF296673_1 D.KIYLLLTK.M 1 2.119 0.082 G mRNA, complete cds; TLR10. (95%) Homo sapiens sulfate/anion transporter SAT-1 protein (SLC26A1) GP:AF297659_1 mRNA, complete cds; member of the G.EGGPAQGEDLGPVSTR.A 1 1.905 0.150 G SLC26 family of anion exchanger proteins, orthologous to rat sat-1. Homo sapiens isolate IF case 6 GP:AF299101_1 immunoglobulin heavy chain variable G.LEWMGWITAYNGNTNYAQK.L 2 3.589 0.241 G region gene, partial cds. Homo sapiens clone CIC 01 GP:AF301486_1 anticardiolipin immunoglobulin light R.FSGSGSGTYYILT.I 2 3.068 0.129 G chain mRNA, partial cds. Homo sapiens clone CIC 03 GP:AF301487_1 anticardiolipin immunoglobulin light R.ASQSLSSWLAWYQQK.P 1 3.200 0.348 G, P chain mRNA, partial cds. 2 3.033 0.232 R.ASQSLSSWLAWYQQKPGK.A 2 3.784 0.265 Supplementary Table 1 79 Homo sapiens clone CIC 11 GP:AF301488_1 anticardiolipin immunoglobulin light -.DIQLTQSPSLLSA.S 2 4.293 0.165 G chain mRNA, partial cds. Homo sapiens clone CIC 19 IPI:IPI00030206.1 GP:AF301490_1 anticardiolipin immunoglobulin light -.EIVLTQSPGTLSVSPGER.A 2 4.960 0.434 G (97%) chain mRNA, partial cds. Homo sapiens MALT lymphoma GP:AF301517_1 immunoglobulin heavy chain gene, K.ESLYLQMDSLR.D 2 2.743 0.231 G partial cds; IgH. Homo sapiens immunoglobulin heavy IPI:IPI00159843.1 GP:AF301523_1 chain variable region gene, partial cds; W.INPNSGGTDYAQK.F 1 3.033 0.274 G, O, P (92%) IgH. 2 2.982 0.335 Homo sapiens immunoglobulin kappa GP:AF301525_1 chain variable region gene, partial cds; A.SQNIGTNLAWYQQK.A 2 2.656 0.183 G IgK. Homo sapiens immunoglobulin kappa IPI:IPI00030205.1 GP:AF301528_1 chain variable region gene, partial cds; R.FSGSGSGTDFILTISR.L 2 3.182 0.397 G (93%) IgK. Homo sapiens immunoglobulin kappa IPI:IPI00022862.1 GP:AF301529_1 R.ASQSVSTNLAWYQQK.P 2 3.200 0.199 G chain variable region gene, partial cds. (92%) R.ASQSVSTNLAWYQQKPGQAPR.L 2 3.984 0.147 Homo sapiens ropporin mRNA, complete cds; sperm-specific binding IPI:IPI00014258.1 GP:AF303889_1 protein; binds rhophilin; expressed at A.AIRVQPQDLIQ.W 1 2.456 0.098 A (95%) higher level in adult testis as compared to 6 month-old fetal testis. Homo sapiens immunoglobulin heavy GP:AF303899_1 R.SEDTAVYYCARAFS.S 2 2.820 0.264 G chain gene, partial cds. Homo sapiens immunoglobulin kappa IPI:IPI00030205.1 GP:AF303905_1 Y.LAWYQQIPGQAPR.L 2 3.811 0.387 G chain gene, partial cds. (92%) Homo sapiens putative prostate IPI:IPI00186564.1 GP:AF304370_1 cancer susceptibility protein G.AEISSPAVERLISSLLR.T 2 2.525 0.080 G, P (95%) HPC2/ELAC2 mRNA, complete cds. L.QLPNFQQSVQE.Y 2 2.618 0.098 Homo sapiens isolate 1287 VH3 GP:AF304490_1 immunoglobulin heavy chain VDJ E.NSLYLQMNCLR.A 2 3.130 0.214 G, O, P region gene, partial cds. Homo sapiens isolate 1316 GP:AF304503_1 immunoglobulin heavy chain VDJ T.HTGTTNYNPSLK.S 2 2.541 0.243 G region gene, partial cds. Homo sapiens isolate 1322 VH1 GP:AF304506_1 immunoglobulin heavy chain VDJ G.WVNPNSGNTGYAQKFQGR.I 2 2.985 0.162 O region gene, partial cds. Homo sapiens isolate 1323 VH3 GP:AF304509_1 immunoglobulin heavy chain VDJ V.KGRSIIPRDNSKKTLHLLM.S 2 2.619 0.170 G region gene, partial cds. Homo sapiens mucolipin 1 (MCOLN1) IPI:IPI00003750.1 GP:AF305579_1 gene, exons 13, 14, and complete R.KPCKLMLQVVK.I 1 2.419 0.138 G (96%) cds. Homo sapiens clone TF2.6 immunoglobulin light chain variable GP:AF306361_1 region mRNA, partial cds; TF2.6 VL; -.KSPSSLSASVGDR.I 2 2.781 0.092 G thyroid peroxidase autoantibody; binds to TPO non-immunodominant region. Homo sapiens clone T3.13 immunoglobulin light chain variable GP:AF306385_1 region mRNA, partial cds; T3.13 VL; F.AATSLQSGVPSR.F 2 2.566 0.108 G thyroid peroxidase autoantibody; binds to TPO immunodominant region. Homo sapiens clone T3.3 immunoglobulin light chain variable GP:AF306388_1 region mRNA, partial cds; T3.3 VL; Y.GTSSLQSGVPSR.F 2 2.672 0.084 G thyroid peroxidase autoantibody; binds to TPO immunodominant region. Homo sapiens Cat eye syndrome GP:AF307451_1 critical region candidate gene number R.GARGGAGGAGGGLG.A 1 1.919 0.184 O 6 (CECR6) mRNA, complete cds. Homo sapiens serologically defined IPI:IPI00103154.1 GP:AF308299_1 breast cancer antigen NY-BR-85 Y.KEPTLASKLRRGDPFTDLCF.L 2 2.955 0.136 G (94%) mRNA, partial cds. Homo sapiens serologically defined GP:AF308301_1 breast cancer antigen NY-BR-87 A.ARGGPCGVLRADGALPALPPDRA.R 2 3.351 0.081 G mRNA, partial cds. Caenorhabditis elegans PXF isoform GP:AF308449_1 R.SPASSGCSSFSTIASIA.A 2 2.877 0.082 O, P C mRNA, complete cds, alternatively
Supplementary Table 1 80 spliced; pxf-C; alternatively spliced; similar to Homo sapiens PDZ-GEF. Homo sapiens clone ST1L_G11 GP:AF308542_1 immunoglobulin heavy chain mRNA, G.PGYCTVWGQGTLVTVSSASTK.G 2 2.937 0.176 G partial cds. Arabidopsis thaliana putative DNA repair protein and transcription factor (XPB2) mRNA, complete cds; AtXPB2; duplication of the Arabidopsis GP:AF308595_1 I.DPALVENVK.Q 1 2.795 0.157 A, O, P thaliana XPB1 sequence in GenBank Accession Number U29168; similar to Homo sapiens xeroderma pigmentosum group 2 3.100 0.115 I.DPALVENVKQ.R 2 2.821 0.218 S.HIERTKILEAFK.T 2 2.216 0.193 Homo sapiens infertility-related sperm IPI:IPI00179819.1 GP:AF311312_1 T.PEAGADK.R 1 1.919 0.095 G, O protein mRNA, complete cds. (99%) Homo sapiens ubiquitin-like fusion protein mRNA, complete cds; similar to Xenopus laevis ubiquitin-like fusion IPI:IPI00015092.3 GP:AF311324_1 L.GNDQELADSVLHLGSSLPRQT.K 2 3.130 0.212 O, P protein encoded by the sequence (91%) presented in GenBank Accession Number L08457. L.RCSASMSLHNSL.V 1 2.208 0.237 Danio rerio ATP synthase lipid binding protein p3 precursor, mRNA, partial GP:AF311603_1 cds; similar to Homo sapiens ATP A.VRGFQTSAISRD.I 2 2.655 0.133 G synthase lipid-binding protein P3 precursor; ATPase protein 9 subunit c. Homo sapiens SAG splice variant mRNA, complete cds; SAG-v; lacks W.DVECDTCAICRVQVMDEGIGVRNWSE GP:AF312226_1 zinc RING finger domain; has no 3 4.333 0.168 P ALNL.I activity as a component of SCF E3 ubiquitin ligase. Homo sapiens NMN IPI:IPI00009726.4 GP:AF312734_1 adenylyltransferase mRNA, complete L.LCGADLLESFAVPN.L 2 2.731 0.100 A (99%) cds; NAD pyrophosphorylase. Homo sapiens tectorin beta (TECTB) GP:AF312827_1 F.QNIPKLSK.V 1 1.946 0.156 A mRNA, complete cds. Homo sapiens anion IPI:IPI00152287.1 GP:AF314959_1 transporter/exchanger-8 (SLC26A8) L.SVVATTTFLTGIIQL.I 2 2.639 0.113 O, P (98%) mRNA, complete cds. L.VQVPQGLTLSLLAR.Q 2 2.315 0.128 S.FHAGPISFFYDIINYCVAL.P 2 3.170 0.164 Homo sapiens anti-oxidized LDL autoantibody variable heavy chain GP:AF316613_1 K.DTLYLEMN.S 1 2.470 0.104 G mRNA, partial cds; autoantibody to epitopes of OxLDL. Homo sapiens anti-oxidized LDL autoantibody variable kappa chain IPI:IPI00024136.1 GP:AF316614_1 -.LVLTQSPATLSLSPGER.V 2 4.363 0.376 G mRNA, partial cds; autoantibody to (93%) epitopes of OxLDL. Homo sapiens T cell receptor beta GP:AF317591_1 Y.FCASSLPGGRELFFGEGSRLT.V 2 3.828 0.313 A chain (BV16S1) mRNA, partial cds. 3 3.904 0.126 Mus musculus FKSG20 (FKSG20) mRNA, complete cds; similar to Homo Q.KFLDIARQTECFFLQKRLQLSVQKPHQ GP:AF318060_1 sapiens FKSG20 encoded by 3 4.068 0.095 A V.I GenBank accession number AF318059. Homo sapiens clone HGSL1 GP:AF320833_1 immunoglobulin light chain lambda 1 S.NTANWYQHLPGTAPK.L 2 3.246 0.254 G mRNA, partial cds. Homo sapiens clone BTSL6 GP:AF320841_1 immunoglobulin light chain variable D.TQKPSGVPDR.F 2 2.574 0.255 G region mRNA, partial cds. Homo sapiens NSD1 (NSD1) mRNA, T.QGEITKEREDECFSCGDAGQLVSCKKP IPI:IPI00102107.1 GP:AF322907_1 3 3.518 0.177 O complete cds; similar to mouse Nsd1. GCPK.V (95%) Homo sapiens ASPL (ASPSCR1) IPI:IPI00065276.1 GP:AF324219_1 A.PKSEPAAEEGALVPPEPIPGTAQ.P 2 2.653 0.139 A, O, P mRNA, complete cds. (98%) L.QVLEDTCR.R 1 1.931 0.221 Homo sapiens PGC-1 related co- GP:AF325193_1 activator mRNA, complete cds; A.FISEIGIEASDLSSLLEQFE.K 2 2.448 0.139 P transcriptional co-activator; PRC.
Supplementary Table 1 81 I.GKIPGRMTR.S 1 1.946 0.090 Homo sapiens FKSG32 (FKSG32) IPI:IPI00101799.1 GP:AF325689_1 mRNA, complete cds; lung carcinoid D.FRNLCKMDVANGVINFQRT.I 2 4.239 0.146 A, O, P (95%) related protein. L.LNIEKNPQKPQYSMAVEFPLVLYDCKF 3 3.756 0.103 ENVK.W Homo sapiens myopalladin mRNA, IPI:IPI00166571.1 GP:AF328296_1 S.LYYEEPLGQPPRFTQKLRSR.E 2 2.233 0.135 O, P complete cds. (92%) T.PVDESDDEIQHDEIPTGK.C 2 2.559 0.101 Homo sapiens butyrophilin precursor IPI:IPI00178403.1 GP:AF329193_1 B7-DC mRNA, complete cds; BTDC; F.IPSCIIAFIF.I 1 2.240 0.143 P (92%) costimulatory molecule. Homo sapiens clone SK-18 IPI:IPI00053682.1 GP:AF329459_1 recombinant antibody light chain VL R.ASQSISSYLNWYQQQPGK.A 2 3.898 0.262 G, O (92%) domain mRNA, partial cds. S.YLNWYQQQPGK.A 2 3.685 1.000 Homo sapiens IFGP1 mRNA, IPI:IPI00186942.1 GP:AF329488_1 E.TQPPGGQVMEGDRLVL.I 1 2.027 0.132 G, O complete cds; membrane receptor. (97%) Y.ENVNVVSGDEVYSLA.Y 2 2.758 0.093 Homo sapiens immunoglobulin kappa IPI:IPI00030206.1 GP:AF329496_1 R.FSGSGSATDFTLTISR.L 2 2.518 0.105 G light chain gene, partial cds. (91%) Homo sapiens chromosome 17 open reading frame 26 (C17orf26) mRNA, GP:AF331643_1 complete cds; GUFA; similar to A.VSLPLRGAGF.S 1 2.117 0.104 O Myxococcus xanthus GUFA: Swissprot Accession Number Q06916. Homo sapiens cytosolic nucleotidase I IPI:IPI00000146.1 GP:AF331801_1 P.FVKALEAVNRR.L 1 1.801 0.163 P mRNA, complete cds; cN-I. (93%) Homo sapiens zinc finger FEZL IPI:IPI00154618.1 GP:AF332890_1 (FKSG36) mRNA, complete cds; R.LPAPLEQ.V 1 2.078 0.134 O, P (91%) similar to Mus musculus Fezl. Y.SELWKSSLRAGGGGGGGGGGGGGG 3 3.826 0.108 GGAPVCGASGLCKTNC.G Homo sapiens testis-specific protein IPI:IPI00171072.1 GP:AF333098_1 S.ENTAQVFAR.D 1 1.881 0.143 G NYD-TSP1 mRNA, complete cds. (99%) Homo sapiens CUB and sushi multiple domains 1 protein mRNA, complete IPI:IPI00163317.1 GP:AF333704_1 G.FFLAGGSEHR.T 2 2.320 0.178 G, O, P cds; CSMD1; candidate for putative (98%) 8p23 tumor supressor. L.KAFQIKGQADIFVSK.F 1 2.172 0.118 Q.GSTTRTCLANLTWSGIQT.E 2 3.335 0.124 Homo sapiens NIR2 mRNA, complete D.GYVAHLGQLEAGSHSHASSGPPRAAL IPI:IPI00163726.1 GP:AF334584_1 cds; similar to Drosophila retinal 2 2.487 0.263 A, G GK.S (91%) degeneration B (rdgB) protein. R.VVAWLSQHN.F 1 1.964 0.098 Homo sapiens NIR3 mRNA, complete GP:AF334585_1 cds; similar to Drosophila retinal D.QTSGEPPEPSSSNGEPLVGRGLKK.Q 2 2.490 0.108 O, P degeneration B (rdgB) protein. K.AALRVVEESWNAYPYTRTR.F 2 2.411 0.119 Homo sapiens bicarbonate transporter-related protein BTR1 mRNA, complete cds; similar to IPI:IPI00015488.2 GP:AF336127_1 I.ALFISITFVL.D 1 2.259 0.107 P dJ79416.2 protein encoded by (91%) GenBank Accession Number AL109976. Homo sapiens FKSG46 (FKSG46) IPI:IPI00000035.1 GP:AF336873_1 mRNA, complete cds; similar to A.RSSPESR.V 1 1.847 0.105 A, P (95%) V1RL1. I.VLLSSLDVLCLGLMTLASGSMV.F 2 2.412 0.100 Homo sapiens C1orf13 mRNA, V.DEQLLSALVMGATGAVGSTYNYLGKKT IPI:IPI00006165.1 GP:AF338436_1 2 2.749 0.241 A complete cds; c112 protein. .N (98%) Homo sapiens PDZ domain-containing IPI:IPI00183575.1 GP:AF338650_1 protein AIPC (AIPC) mRNA, complete K.VGCYDANDA.S 1 1.900 0.083 A, P (93%) cds; activated in prostate cancer. S.NDKRRFSKGGKTDFQSSDCLAR.Q 2 2.317 0.183 Homo sapiens clone HSK-2 GP:AF338912_1 immunoglobulin kappa light chain A.YTFGKGTK.L 1 2.100 0.326 G variable region mRNA, partial cds. K.APNLLIYGA.S 1 2.106 0.151 Homo sapiens clone HSK-53 GP:AF338921_1 immunoglobulin kappa light chain -.AIQMTQSPSSL.S 2 2.744 0.186 G variable region mRNA, partial cds. -.AIQMTQSPSSLSA.P 2 3.349 0.219 GP:AF338924_1 Homo sapiens clone HSK-51 E.VVMTQSPDTLSVSPGER.A 2 4.785 0.413 O, P Supplementary Table 1 82 immunoglobulin kappa light chain variable region mRNA, partial cds. Homo sapiens clone HSK-15 GP:AF338925_1 immunoglobulin kappa light chain F.IAWYQQK.P 1 2.095 0.099 G variable region mRNA, partial cds. F.IAWYQQKPGQ.P 1 2.796 1.000 Homo sapiens clone k149-7 psoriasis GP:AF343369_1 vulgaris immunoglobulin heavy chain R.VDGGTTDYAAPVK.G 2 3.295 0.306 G mRNA, partial cds. Homo sapiens clone k149-13 GP:AF343375_1 psoriasis vulgaris immunoglobulin K.GLEWMGIIYPR.D 2 2.538 0.274 G heavy chain mRNA, partial cds. Homo sapiens clone k177-5 psoriasis GP:AF343410_1 vulgaris immunoglobulin heavy chain L.IYWDDDQR.Y 2 2.686 0.159 G mRNA, partial cds. Homo sapiens clone k177-14 GP:AF343419_1 psoriasis vulgaris immunoglobulin K.STSTAYLQWSSLK.A 1 2.329 0.232 G heavy chain mRNA, partial cds. 2 3.391 0.385 Homo sapiens channel-kinase 1 (CHAK1) mRNA, complete cds; IPI:IPI00045083.1 GP:AF346629_1 I.ILSHIVSLFCCICKRR.K 2 2.800 0.120 G ChaK1; melanoma alpha-kinase; (98%) protein kinase/ion channel. Homo sapiens C2H2 zinc finger GP:AF347021_1 A.MKNNEISVIQNGGIPQ.L 1 3.080 0.241 G, O protein (SALL3) gene, complete cds. A.PAAPSAAPAPAAPAPAP.A 2 3.289 0.263 Homo sapiens clone 26P-2 IPI:IPI00018563.3 GP:AF348829_1 immunoglobulin heavy chain variable K.SINTAYLQWSSLQ.A 1 2.509 0.286 G (91%) region mRNA, partial cds; VH 5-51. 2 3.889 0.420 Homo sapiens urea transporter UT-A1 IPI:IPI00020020.1 GP:AF349446_1 T.GHYNLFFPTTLVEPVSSVPNI.T 2 3.723 0.290 G (SLC14A1) mRNA, complete cds. (91%) Homo sapiens C9orf12 mRNA, complete cds; contains no predicted IPI:IPI00009371.1 GP:AF351202_1 transmembrane regions; similar to G.KWKQISK.Y 1 1.823 0.110 P (96%) protein encoded by GenBank Accession Number AK023225. Homo sapiens isolate patient 4 immunoglobulin heavy chain variable GP:AF355608_1 R.LAPGQGLQWMGGIIPIFGTANYAQK.F 2 2.908 0.103 G region gene, partial cds; tumor- related. Homo sapiens isolate patient 5 immunoglobulin heavy chain variable GP:AF355609_1 R.ITITADK.S 1 2.170 0.150 G region gene, partial cds; tumor- related. Mus musculus autoimmune infertility- related protein (Airp) mRNA, partial GP:AF356186_1 cds; mAIRP; similar to cytosolic 5' R.WGLEIDEALFLAGAPKGP.I 2 2.794 0.238 O nucleotidase and Homo sapiens AIRP (hAIRP). Homo sapiens axonemal dynein heavy chain 8 (DNAH8) mRNA, complete cds; involved in sperm IPI:IPI00163906.1 GP:AF356519_1 K.GITFIFTD.S 1 1.947 0.187 G, P motility; implicated in sperm flagellar (98%) assembly; motor unit of axonemal dynein. V.ASLYGRKQSEDIISFIKSEVHLAIPN.V 3 3.969 0.151 Homo sapiens nuclear receptor transcription cofactor (SHARP) mRNA, complete cds; contains three GP:AF356524_1 RNA recognition motifs (RRMs) at the F.KKFGKVTSVQIHGTSE.E 1 2.334 0.218 G, O, P amino-terminus and a repression SMRT-interaction domain (SID) at the carboxy-terminus. N.KIKVDFANR.E 2 2.247 0.139 P.EMEDAR.V 1 2.013 0.140 Homo sapiens BACH2 transcription IPI:IPI00220582.1 GP:AF357835_1 L.DNFSCLSQEVCRDIQSP.E 2 2.701 0.091 P factor mRNA, complete cds. (94%) Homo sapiens Bardet-Biedl syndrome IPI:IPI00045368.1 GP:AF359281_1 K.KAPEFPILEK.Q 1 2.320 0.153 A type 4 mRNA, complete cds; BBS4. (94%) Homo sapiens BRCA1-binding helicase-like protein BACH1 mRNA, IPI:IPI00168384.1 GP:AF360549_1 complete cds; BRCT-binding helicase- T.EVHNLDAK.V 1 2.626 0.091 O (99%) like protein BACH1; member of DEAH helicase family.
Supplementary Table 1 83 Homo sapiens mitochondrial GTP binding protein 2 mRNA, complete GP:AF360743_1 R.GPRRLCTRRSSGAPAPGSGA.T 1 2.049 0.144 G cds; nuclear gene for mitochondrial product; NTGP2. Homo sapiens kappa 1 light chain GP:AF361758_1 variable region (SDNK1) gene, partial N.WYQKKPGEAPK.F 2 2.865 1.000 G cds. Q.ASQDIANHLNWYQKK.P 2 2.306 0.107 Homo sapiens methylmalonyl-CoA epimerase mRNA, complete cds; IPI:IPI00107722.1 GP:AF364547_1 R.VLKAAAANAVGLFSRLQAPIPTVR.A 2 2.631 0.100 O nuclear gene for mitochondrial (96%) product; racemase. Q.EVTTVQLQPAQEVTTVQLQPVAGQLS IPI:IPI00101878.1 GP:AF367249_1 Homo sapiens unknown mRNA; my1. 3 4.115 0.092 O NSSGGAVATEA.P (94%) Homo sapiens chondroadherin mRNA, IPI:IPI00014592.1 GP:AF371328_1 C.ASPAKFKGQHIRDTDAFR.S 2 2.512 0.226 O complete cds. (91%) Homo sapiens clone CHO GP:AF376947_1 immunoglobulin heavy chain variable H.LVESGGGVVQPGTSLR.L 2 4.658 0.389 G, O region gene, partial cds. Homo sapiens peptidoglycan recognition protein L precursor (PGLYRP) mRNA, complete cds; innate immunity pattern recognition IPI:IPI00163207.1 GP:AF384856_1 A.SLPLLMDSVIQALAELEQK.V 2 6.016 0.412 O, P molecule; binds peptidoglycan; (98%) contains two transmembrane domains, two extracellular domains, and one cytoplasmic domain; memb 3 5.340 0.348 K.EYGVVLAPDGSTVAVEPLLAGLEAGLQ 2 3.916 0.240 GR.R 3 5.495 0.484 M.AAPWETGDTFPDVVAIAPDVR.A 2 4.453 0.164 R.AGLLRPDYALLGHR.Q 2 2.965 0.361 3 4.126 0.312 R.DGSPDVTTADIGANTPDATK.G 2 5.514 0.447 R.EGKEYGVVLAPDGSTVAVEPLLAGLEA 3 6.138 0.428 GLQGR.R R.GWHWVGAHTLGHNSR.G 2 3.816 0.314 R.HTASAWLMSAPNSGPHNR.L 2 2.844 0.296 3 4.670 0.327 R.PSLSHLLSQYYGAGVAR.D 2 5.819 0.490 3 4.800 0.380 R.TWPHFTATVKPRPA.R 2 2.421 0.229 R.VINLPLDSMAAPWETGDTFPDVVAIAP 3 3.875 0.239 DVR.A Homo sapiens bromodomain- containing 4 (BRD4) mRNA, complete cds; mitotic chromosome-associated GP:AF386649_1 protein; HUNKI; MCAP; CAP; similar M.KSSPPPFIATQVPVLEPQLPGSV.F 2 2.800 0.178 G to murine product encoded by GenBank Accession Number AF273217. Homo sapiens endothelial and smooth GP:AF387547_1 muscle cell-derived neuropilin-like W.LQIDLNKEKKITGIITTGSTM.V 2 2.673 0.199 A protein (ESDN) mRNA, complete cds. Homo sapiens NOPAR mRNA, GP:AF388364_1 L.AFSDFLSCAQHGPLVYGLSCMLQT.V 2 2.768 0.173 A complete cds. Homo sapiens melanoma inhibitory GP:AF390175_1 activity protein 2 mRNA, complete V.QIEEVFISEEIQ.M 2 3.751 0.158 A, O, P cds; MIA2. Homo sapiens C21orf70 isoform B protein (C21orf70) mRNA, complete IPI:IPI00081249.1 GP:AF391114_1 I.DPSALVQKLELD.V 2 2.735 0.126 G, O cds, alternatively spliced; PRED56; (94%) alternatively spliced. Homo sapiens coagulation factor II S.HTSTTEAAYFAYLLCVCVSSISCCIDPLI IPI:IPI00012755.2 GP:AF391809_1 (thrombin) receptor (F2R) gene, 3 3.889 0.226 A YY.Y (93%) complete cds. Homo sapiens oxysterol-binding protein-like protein OSBPL9 GP:AF392445_1 A.GSVEEHKSVIMHLL.S 2 3.005 0.081 A, P (OSBPL9) mRNA, complete cds; OSBP4. T.MPSQTVLPPEPVQLCK.S 2 2.235 0.101 Homo sapiens inositol IPI:IPI00044346.1 GP:AF393812_1 S.LVANPVK.E 1 2.409 0.084 A, O, P hexakisphosphate kinase 3 mRNA, (97%) Supplementary Table 1 84 complete cds; IP6K3. Homo sapiens anti-keratin GP:AF394738_1 immunoglobulin light chain VL region A.SRLESGVPSR.F 1 2.046 0.117 G mRNA, partial cds. S.NSLAWYQQK.P 1 3.000 0.294 2 2.671 0.228 Homo sapiens DIBD1 (DIBD1) mRNA, complete cds; disrupted in bipolar IPI:IPI00183652.1 GP:AF395532_1 disorder 1; similar to Saccharomyces A.EHRTELSGNKAGQVWAPEGSTAFK.C 2 2.576 0.100 G (93%) cerevisiae ALG9 in GenBank Accession Number CAA65277.1. Homo sapiens sorting nexin 18 GP:AF395536_1 G.LFPASYVQVIR.A 1 2.174 0.135 A (SNX18) mRNA, complete cds. Homo sapiens glycogenin-interacting protein 1 mRNA, complete cds; GP:AF396651_1 A.LQLNGGQYWAVTSPER.S 2 3.165 0.127 G, O, P GNIP1; contains RING-finger, B-box, coiled-coill and B30.2 domains. Homo sapiens LRP15 mRNA, GP:AF396933_1 I.FKDLHQLRVLNLSK.N 1 1.804 0.098 P complete cds. Homo sapiens isolate F8 GP:AF398956_1 immunoglobulin heavy chain variable -.EVQLVQSGGGLVQPGR.S 2 4.245 0.337 G, O region mRNA, partial cds. Homo sapiens pigment epithelium- IPI:IPI00006114.2 GP:AF400442_1 derived factor (SERPINF1) mRNA, A.AAVSNFGYDLYR.V 2 3.700 0.472 O, P (92%) complete cds; PEDF. A.LSLGAEQR.T 1 1.853 0.106 A.VSNFGYDLYR.V 2 2.797 0.330 K.ELLDTVTAPQK.N 1 2.347 0.214 2 3.367 0.267 K.LAAAVSNFGYDLYR.V 2 4.406 0.534 K.LQSLFDSPDFSK.I 2 3.609 0.296 K.LTQVEHR.A 2 2.393 0.133 K.SSFVAPLEK.S 1 2.015 0.188 K.TSLEDFYLDEER.T 2 3.447 0.321 L.DLQEINNWVQAQMK.G 2 2.792 0.243 L.KLSYEGEVTK.S 2 2.936 0.321 L.LSPLSVATALSALSLGAEQR.T 2 2.292 0.224 N.VLLSPLSVATALSALSLGAEQR.T 3 5.448 0.477 R.AGFEWNEDGAGTTPSPGLQPAHLTFP 3 3.923 0.289 LDYHLNQPF.I R.AGFEWNEDGAGTTPSPGLQPAHLTFP 3 4.651 0.354 LDYHLNQPFIFVLR.D R.ALYYDLISSPDIHGTYK.E 2 4.897 0.425 3 3.638 0.382 R.ALYYDLISSPDIHGTYKELLDTVTAPQK. 3 3.759 0.358 N R.DTDTGALLFIGK.I 1 2.536 0.212 2 4.787 0.287 R.KTSLEDFYLDEER.T 2 4.231 0.222 R.LDLQEINNWVQAQ.M 2 3.924 0.291 R.LDLQEINNWVQAQMK.G 2 5.087 0.394 3 4.235 0.280 R.SSMSPTTNVLLSPLSVATALSALSLGAE 2 4.058 0.394 QR.T R.TESIIHR.A 2 2.234 0.171 V.SNFGYDLYR.V 2 2.508 0.203 Homo sapiens type II gonadotropin- releasing hormone receptor gene, GP:AF403014_1 A.FTLGCRRGHQELSIDSSK.E 2 2.843 0.095 A, O partial cds; type II GnRH receptor; selenocysteine. Homo sapiens clone 6b5B12 anti- pneumococcal capsular GP:AF408719_1 polysaccharide immunoglobulin heavy P.DGNEEHYVDSVKGR.F 2 2.979 0.094 G chain variable region mRNA, partial cds; Vh3-07. Homo sapiens clone CbB2 anti- pneumococcal capsular GP:AF408728_1 polysaccharide immunoglobulin heavy Q.GLEWVADIK.E 1 2.402 0.086 G chain variable region (IgG2) mRNA, partial cds; Vh3-7. GP:AF408730_1 Homo sapiens clone CbE2 anti- -.EVQLVESGGHLVQPGGSLR.L 2 5.987 0.468 G, P Supplementary Table 1 85 pneumococcal capsular polysaccharide immunoglobulin heavy chain variable region (IgG2) mRNA, partial cds; Vh3-48. 3 4.040 0.225 Q.LVESGGHLVQPGGSLR.L 2 2.353 0.240 Homo sapiens clone DM5 anti- pneumococcal capsular GP:AF408741_1 polysaccharide immunoglobulin light Q.PPSVSAAPGQR.V 1 2.212 0.256 G, O chain variable region (IgG2) mRNA, partial cds; Vl1-v117. V.TQPPSVSAAPGQR.V 2 2.498 0.345 Homo sapiens anti-pneumococcal capsular polysaccharide GP:AF408743_1 immunoglobulin light chain variable R.RLLYEVSNR.D 2 3.591 0.245 G region (IgG2) mRNA, partial cds; Vk2- A17. Homo sapiens isolate NSB12-4-K3-G6 GP:AF410498_1 immunoglobulin kappa chain variable Q.GQSDVSSNLAWYQQKPGQAPR.L 2 3.092 0.284 G region gene, partial cds. S.DVSSNLAWYQQK.P 2 2.436 0.108 Homo sapiens isolate NSB11-4-K3-H9 GP:AF410559_1 immunoglobulin kappa chain variable R.ASQSVSSNLAWYQQKLARLPG.S 3 3.942 0.166 G, O, P region gene, partial cds. Homo sapiens isolate NSB11-4-K3-C8 IPI:IPI00178198.1 GP:AF410569_1 immunoglobulin kappa chain variable R.ASQGVSSYLAWYQQKPGQ.A 2 2.606 0.086 G (93%) region gene, partial cds. Homo sapiens isolate NSB11-4-K3-B6 GP:AF410576_1 immunoglobulin kappa chain variable R.ASQSVSSSYLAWYQQKLARLPG.S 3 3.539 0.206 A, P region gene, partial cds. S.SMVHPAGPLASQTGSVAVGLGHTSLS 3 3.745 0.132 PSADWSLK.I Homo sapiens G protein-coupled IPI:IPI00044280.1 GP:AF411117_1 receptor (GPR103) mRNA, complete K.KNVLSAVCYCIVNK.T 2 2.659 0.168 G (98%) cds. Homo sapiens collagen XXI (COL21A1) mRNA, complete cds; K.SQDDVKDAAQAARDSKITLFAIGVGSE IPI:IPI00218749.1 GP:AF414088_1 FACIT collagen; similar to protein 3 3.554 0.142 O TEDAE.L (98%) encoded by GenBank Accession Number AL136624. S.NVFPEGLPPSYVFVSTQRFKVKKI.W 2 2.416 0.108 Homo sapiens N-methyl-D-aspartate receptor 3A (GRIN3A) mRNA, IPI:IPI00154902.1 GP:AF416558_1 complete cds; NR3A; glutamate R.KPGEGAR.A 1 1.872 0.151 G (94%) receptor; ionotropic; NMDA receptor subunit. Mus musculus brown fat inducible thioesterase 2 mRNA, complete cds; GP:AF416923_1 BFIT2; acyl-CoA thioesterase; acyl- K.QVIPLTEEEKT.E 1 2.061 0.157 G CoA hydrolase; similar to Homo sapiens BFIT2. Homo sapiens cyclin-dependent IPI:IPI00102425.1 GP:AF419845_1 kinase inhibitor-related protein Y.LANDVIQNSKRKGPEFTKDFAPV.I 3 3.871 0.210 O (95%) (P15RS) mRNA, complete cds. Homo sapiens anthrax toxin receptor IPI:IPI00219619.1 GP:AF421380_1 F.SVEDTYLLCPAPI.L 2 2.488 0.103 A, O mRNA, complete cds; ATR. (99%) P.STICAGESFQVVVRGNGFR.H 2 2.668 0.097 Homo sapiens nm23-phosphorylated IPI:IPI00154910.1 GP:AF425252_1 unknown substrate mRNA, complete Y.EDQGLGETTPL.T 1 2.709 0.110 O (95%) cds. Homo sapiens clone SK-35 IPI:IPI00026197.1 GP:AF425258_1 immunoglobulin light chain variable -.DVVMTQSPDSLAVSLGER.A 2 4.766 0.315 O (93%) region gene, partial cds; VL domain. Homo sapiens clone KM-62 GP:AF425259_1 immunoglobulin light chain variable -.DIQMTQSPSYLSASVGDR.V 2 4.284 0.415 O region gene, partial cds; VL domain. Homo sapiens putative tetracycline GP:AF427492_1 transporter-like protein mRNA, I.RGLCNGLGPALYGFIFYIFHVELKEL.P 2 2.660 0.101 A, P complete cds. T.AIALLDICFILVAVPESLPEKMR.P 2 2.378 0.105 Homo sapiens a4 anti-Der p1 scFv GP:AF428046_1 R.ASQIISSSLNWYQQKPGK.A 2 3.026 0.128 G antibody mRNA, partial cds. Homo sapiens c15 anti-Der p1 scFv GP:AF428047_1 -.QVQLSESGGGLVQPGGSLR.L 2 3.127 0.245 G, P antibody mRNA, partial cds. Q.LSESGGGLVQPGGSLR.L 2 2.779 0.117
Supplementary Table 1 86 Homo sapiens T cell receptor beta variable region, Vbeta 5S6A3N2T- GP:AF430650_1 GAGPSGELFF-JBeta 2.2 mRNA, F.QYFREEENGRGNSPPRFSGLQ.F 2 2.466 0.153 A, P partial cds; Vbeta 5S6A3N2T- GAGPSGELFF-JBeta 2.2. P.EVAAFEPSEAEIS.H 2 3.302 0.239 Homo sapiens NALP4 mRNA, complete cds; novel member of the NALP family; related to NALP1 Genbank Accession Number IPI:IPI00218615.1 GP:AF442488_1 R.NKSVRYLDLSANVLKDEGLK.T 2 2.644 0.139 O, P AF310105, NALP2 Genbank (95%) Accession Number AF310106 and NALP3 Genbank Accession Number AF418985. Homo sapiens isolate GH-2 GP:AF442753_1 immunoglobulin lambda light chain S.YELTQALSVSVALGQTAK.I 2 4.632 0.472 G variable region mRNA, partial cds. Homo sapiens isolate JC-4 GP:AF442756_1 immunoglobulin heavy chain variable -.EVPLLESGGGLIQPGGSLR.L 2 2.766 0.164 G, O region mRNA, partial cds. P.LLESGGGLIQPGGSLR.L 2 4.287 0.278 Homo sapiens isolate JW-5 IPI:IPI00024136.1 GP:AF442759_1 immunoglobulin kappa light chain -.EIVLTQSPATLSLSPGDR.A 1 2.397 0.250 G, O (92%) variable region mRNA, partial cds. 2 3.151 0.341 Homo sapiens isolate MW-6 GP:AF442760_1 immunoglobulin heavy chain variable Q.VTFSVDTSISTAYL.Q 1 2.624 0.131 G region mRNA, partial cds. Homo sapiens isolate PC-7 GP:AF442762_1 immunoglobulin kappa light chain S.TPLTFGPGTK.V 1 2.142 0.215 G variable region mRNA, partial cds. Homo sapiens isolate PR-8 GP:AF442764_1 immunoglobulin lambda light chain N.WYQQVPGSAPK.L 2 2.584 0.174 A variable region mRNA, partial cds. Homo sapiens isolate WD-9 GP:AF442766_1 immunoglobulin heavy chain variable W.SYFDPWGQGALVTVSSASTK.G 2 3.094 0.230 G region mRNA, partial cds. Homo sapiens ATR interacting protein GP:AF451323_1 V.VSLLLSGVGADSAAGEGNRSLVHR.L 2 2.515 0.204 P (ATRIP) mRNA, complete cds. Homo sapiens mRNA for IgA protein, GP:AJ001413_1 Q.GALVTVSSASPTSPK.V 2 3.618 0.411 P BA-1F. Y.FDYWGQGALVTVSSASPTSPK.V 2 3.844 0.312 Homo sapiens mRNA for obscurin IPI:IPI00016383.1 GP:AJ002535_1 G.LPKVEEQEKVKE.A 2 3.128 0.127 A, G (OBSCN gene). (96%) T.GVQWCLQGLPLQSNEVTEVAVRDGRI 2 2.200 0.174 HTLRLK.G V.VSTAIQEFYKKYAEE.A 2 2.970 0.183 Homo sapiens Immunoglobulin M GP:AJ002649_1 heavy chain variable region gene (cell K.YYIDSVK.G 1 2.073 0.122 G PM27). Homo sapiens mRNA for X-like 1 IPI:IPI00023618.2 GP:AJ005821_1 A.FYRKNDPLDAAIFYLAM.K 2 2.808 0.089 A, P protein. (96%) T.TSLPAYRAQLLHQGLSTSHFA.W 2 2.722 0.084 Homo sapiens mRNA for L19 anti- IPI:IPI00030205.1 GP:AJ006113_1 (ED-B) scFV recombinant antibody, A.SQSVSSSFLAWYQQK.P 2 3.639 0.100 G (94%) partial. R.ASQSVSSSFLAWYQQKPGQAPR.L 2 2.809 0.127 Homo sapiens mRNA for AND-1 L.EREFRCVELADLMTQNAVNLAIKYASR IPI:IPI00219429.1 GP:AJ006266_1 3 4.233 0.123 A protein. SR.K (93%) S.GRPRQRSHILEDDENSVDISMLKTGSS 3 4.477 0.103 LLK.E Homo sapiens mRNA for IgG heavy GP:AJ006648_1 chain variable region, clone ac.r.4, K.SKKTGGDTDYAAPVK.G 2 3.505 0.323 O partial. Homo sapiens mRNA for IgG heavy GP:AJ006652_1 chain variable region, clone Q.GTLVPVSSASTK.- 1 1.996 0.178 G ac.ebv.105.8, partial. Homo sapiens mRNA for PBK1 E.DICLFTKDEPNSTPEKTEQFYRKLLNKH GP:AJ007398_1 3 3.970 0.162 A protein. GI.K Homo sapiens mRNA for stromal IPI:IPI00177925.1 GP:AJ007798_1 T.EIQEQAFVLLSDLLLIFSPQMI.V 2 3.022 0.110 P antigen 3 (STAG3 gene). (92%) Homo sapiens mRNA for GP:AJ010443_1 immunoglobulin IgG3 heavy chain, Q.GTFVTVSSASTK.G 2 3.618 0.384 G, O anti-RhD, therad 7. GP:AJ010444_1 Homo sapiens mRNA for K.LLIYEASTLETGVPSR.F 2 3.691 0.245 G, O, P Supplementary Table 1 87 immunoglobulin kappa light chain, anti-RhD, therad 10. R.WLAWFQQKPGK.A 2 3.282 0.180 Homo sapiens mRNA for kinesin-like GP:AJ010479_1 V.KGNIELK.R 1 2.132 0.107 P protein 2. Homo sapiens mRNA for transcription IPI:IPI00159602.1 GP:AJ011812_1 F.VASSSKDEGQEDPY.G 2 2.495 0.117 A, O, P factor NRF, partial. (93%) P.LKEIPPADIPKNK.K 2 3.278 0.139 T.ENANDAIGILNNSASFNKMSIEYKYEMM 2 2.490 0.107 PNR.T Homo sapiens mRNA for homeobox IPI:IPI00031894.1 GP:AJ011863_1 G.PQRSVDVVVSSVFLLTL.S 2 2.808 0.191 G protein LSX. (94%) Homo sapiens mRNA for NAALADase IPI:IPI00216502.1 GP:AJ012371_1 V.LGLGLGAAALLGLGIILGHFAIPKKA.N 3 4.666 0.211 O L protein. (96%) Homo sapiens IGHV3-33 gene GP:AJ130898_1 encoding immunoglobulin heavy chain R.AEDTAVYYCGRDRIKGDAIIH.N 3 3.525 0.160 G variable region, partial. Homo sapiens mRNA for birch pollen allergen specific immunoglobulin IPI:IPI00152918.1 GP:AJ131055_1 N.TYLNWFQHR.P 2 2.508 0.186 G gamma chain (BAB2-L), complete V-J (91%) region; complete V-J region. Homo sapiens mRNA for birch pollen allergen specific immunoglobulin GP:AJ131059_1 Q.TSTLQTGVPSR.F 2 2.310 0.132 G gamma chain (BAB4-L), complete V-J region; complete V-J region. R.ASQSISKYLAWYQQR.P 2 2.374 0.255 Homo sapiens mRNA for immunoglobulin light chain variable GP:AJ132428_1 K.LLIYGNNNRPSGVPDR.F 2 2.806 0.116 G region (partial), Fab fragment, clone PSG59. Homo sapiens mRNA for IPI:IPI00005484.1 GP:AJ132562_1 S.INATGGTTDYADSVK.G 2 2.999 0.172 P immunoglobulin heavy chain, partial. (99%) Homo sapiens mRNA for GP:AJ132849_1 immunoglobulin heavy chain variable R.VTLSVDTSK.N 1 2.003 0.179 G, P region, clone MGgisa20, partial. Homo sapiens mRNA for leucocyte IPI:IPI00090327.1 GP:AJ133421_1 E.ALTVYNLNR.T 2 2.801 0.089 P vacuolar protein sorting. (94%) Homo sapiens mRNA for IgG, clone GP:AJ222559_1 R.VTISTDTSK.N 1 2.036 0.097 G GD2. Homo sapiens mRNA for IgG, clone GP:AJ222561_1 Y.SNWFDPWGQGTLVTVSSASTK.G 2 2.857 0.188 G GD5. Homo sapiens mRNA for IgG, clone GP:AJ222563_1 W.NWIRQPPGKGLEWIGEINHSGR.T 2 2.553 0.084 G GE1. Homo sapiens mRNA for IgG, clone GP:AJ222564_1 G.WLALYFDYWGQGTLVTVSSASTK.G 2 3.071 0.083 G GG3. Mouse DNA for heavy chain of GP:AJ222590_1 recombinant single chain Fv against Q.LKESGPGL.V 1 2.015 0.267 G human C3a receptor. Homo Sapiens light chain variable IPI:IPI00003486.1 GP:AJ224084_1 G.EIALTQSPGTLSLSPGER.A 2 4.444 0.383 G, O region cDNA. (91%) Homo sapiens mRNA for MOCS1A & GP:AJ224328_2 R.ADSDANSKCLSPGSW.A 2 3.512 0.138 O, P MOCS1B proteins, complete CDSs. Homo sapiens DNA for Ig heavy chain GP:AJ225736_1 variable region, isolate cell G2 55; VH K.NTLYLQMDSLK.I 2 3.506 0.289 G 3 family gene. Homo sapiens DNA for Ig heavy chain IPI:IPI00173849.1 GP:AJ225746_1 variable region, isolate cell G2 68; VH R.AEDTAVYYCARYD.F 2 3.152 0.126 G (96%) 3 family gene. Homo sapiens DNA for Ig heavy chain GP:AJ225751_1 variable region, isolate cell G2 80; VH E.TDGGTTEYAAPVK.D 2 2.904 0.272 G 3 family gene. Homo sapiens DNA for Ig heavy chain IPI:IPI00178741.1 GP:AJ225753_1 variable region, isolate cell G2 84; VH S.YDGSNTYYADSVK.G 2 2.577 0.365 G (94%) 3 family gene. Y.DGSNTYYADSVK.G 1 2.206 0.122 Homo sapiens DNA for rearranged GP:AJ227733_1 immunoglobulin heavy chain gene, 7- K.NTLYLQMNSLQ.A 1 2.939 0.172 G, O 6VH3. 2 3.676 1.000 Homo sapiens partial mRNA for immunoglobulin G heavy chain GP:AJ233697_1 K.LLESGGGFVQPGGSLR.L 2 3.661 0.422 G variable region (IGHV3 gene), clone pComb3-LO-ie19. Homo sapiens partial mRNA for GP:AJ233709_1 immunoglobulin G heavy chain S.IYDSGNSDYNPSLKSR.V 2 3.361 0.174 G variable region (IGHV4 gene), clone Supplementary Table 1 88 pComb3-NK-ib22. Homo sapiens partial mRNA for immunoglobulin lambda-3 variable GP:AJ233719_1 K.PGQAPILVIYGK.N 1 2.860 0.333 G region (IGLV3 gene), clone pComb3- LO-ie21. Homo sapiens partial mRNA for immunoglobulin lambda-1 variable GP:AJ233720_1 L.PGTAPKLLIYQ.N 1 2.313 0.092 G region (IGLV1 gene), clone pComb3- LO-ie31. Homo sapiens partial mRNA for immunoglobulin kappa-4 variable IPI:IPI00026197.1 GP:AJ233726_1 K.NYLGWYQQKPGQPPK.L 2 3.802 0.382 G region (IGKV4 gene), clone pComb3- (96%) GG-ib29. Homo sapiens partial mRNA for immunoglobulin lambda-1 variable GP:AJ233729_1 T.ANHLVFGGGTK.L 1 2.680 0.085 G region (IGLV1 gene), clone pComb3- NK-ib07. Homo sapiens partial mRNA for immunoglobulin lambda-3 variable GP:AJ233730_1 K.AGQSPVLVIYQ.D 1 2.243 0.192 G region (IGLV3 gene), clone pComb3- NK-ib22. Homo sapiens mRNA for GP:AJ235649_1 immunoglobulin heavy chain variable K.NQFFLQ.M 1 1.880 0.108 G region, patient 1, clone 1. Homo sapiens mRNA for anti-HCV E2 IPI:IPI00030205.1 GP:AJ236551_1 A.SQSVRSNYLAWYQQK.P 2 2.893 0.197 G antibody, VK segment, clone 1:11. (94%) Homo sapiens mRNA for anti-HCV E2 GP:AJ236553_1 R.LLIYGGNTR.A 2 2.740 0.089 O antibody, VK segment, clone L3. Homo sapiens mRNA for IGHV gene for immunoglobulin heavy chain IPI:IPI00182107.1 GP:AJ238040_1 -.EAQLVESGGGLVQPGGSLR.L 2 2.819 0.273 O, P variable region, IgM multiple myeloma (92%) patient MOR. Homo sapiens thyroid peroxidase- specific immunoglobulin heavy chain GP:AJ238326_1 -.EVQLVQSGAEMK.K 1 3.105 0.381 G variable region, clone ICA1; anti- thyroid peroxidase ScFv antibody. 2 3.501 0.267 Homo sapiens thyroid peroxidase- specific immunoglobulin heavy chain GP:AJ238327_1 -.QVQLVQSGAEVTK.P 2 2.868 0.096 G variable region, clone ICA5; anti- thyroid peroxidase ScFv antibody. Homo sapiens thyroid peroxidase- specific immunoglobulin lambda light GP:AJ238329_1 Q.SVLTQPPSVSAAPGQR.V 2 2.507 0.266 G chain variable region, clone ICA1; anti-thyroid peroxidase ScFv antibody. Homo sapiens thyroid peroxidase- specific immunoglobulin lambda light GP:AJ238331_1 -.QSVVTQPPSVSAAPGQK.V 1 2.232 0.134 G chain variable region, clone ICB7; anti-thyroid peroxidase ScFv antibody. 2 2.522 0.234 Homo sapiens mRNA for GP:AJ239340_1 immunoglobulin heavy chain variable R.ITMSVDTSK.N 1 1.936 0.276 G region, ID 37; ID 37. Homo sapiens mRNA for GP:AJ239350_1 immunoglobulin heavy chain variable -.ALQLVESGGGLVQPGGSLR.L 2 3.098 0.207 O region, ID 30; ID 30. Homo sapiens mRNA for GP:AJ239355_1 immunoglobulin heavy chain variable R.QAPGQGLEWMGGIIPIFGK.A 2 3.103 0.374 G region, ID 71; ID 71. Homo sapiens mRNA for GP:AJ239360_1 immunoglobulin heavy chain variable R.QAPGQGLEWLGR.I 2 2.535 1.000 G region, ID 35; ID 35. Homo sapiens mRNA for GP:AJ239364_1 immunoglobulin heavy chain variable -.EVQLVESGGGLIKPGGSLR.L 2 4.768 0.446 G, O, P region, ID 73; ID 73. 3 3.865 0.157 Q.LVESGGGLIKPGGSLR.L 2 4.800 0.381 Homo sapiens mRNA for GP:AJ239368_1 immunoglobulin heavy chain variable K.NTLYLQMK.S 1 2.100 0.122 G region, ID 65; ID 65. Homo sapiens mRNA for GP:AJ239380_1 immunoglobulin heavy chain variable E.WVANIKRDGSEEYYVDSVK.G 3 3.516 0.314 P region, ID 82; ID 82. Homo sapiens mRNA for IPI:IPI00024136.1 GP:AJ241388_1 immunoglobulin light chain variable R.FSGSGSGTDFTLNISR.L 2 4.304 0.547 G (92%) region, clone Z5scFvII-7.1. Supplementary Table 1 89 Homo sapiens mRNA for GP:AJ241400_1 immunoglobulin light chain variable -.EIVLTQSPDSLAVSLGER.A 2 2.735 0.184 G, O region, clone Z5scFvV5. K.DYLAWYQQKPGQPPK.L 1 3.508 0.376 2 3.809 0.443 Homo sapiens mRNA for GP:AJ241402_1 immunoglobulin light chain variable S.DYLAWYQQR.P 1 2.449 0.226 G region, clone Z5scFvV7. Homo sapiens mRNA for GP:AJ241403_1 immunoglobulin light chain variable -.HVILTQPTSVSVAPGQTAR.L 2 2.920 0.330 G, O region, clone Z5scFvV8. K.PGQAPVLVVYDDATRPSGIPER.F 2 2.686 0.132 Homo sapiens mRNA for GP:AJ241409_1 immunoglobulin light chain variable Q.KPRQAPVLVIYAKNIR.P 2 2.792 0.158 P region, clone Z5scFvV14. Homo sapiens mRNA for GP:AJ241410_1 immunoglobulin light chain variable R.SSGSIASNYVQWYQKR.P 2 3.708 0.289 G region, clone Z5scFvV15. Homo sapiens mRNA for E-MAP- GP:AJ242501_1 115/95 (MAP gene); isotype of E- S.KPSRLDVTNSESPEIPL.N 1 2.649 0.091 G MAP-115; E-MAP-115-95. Homo sapiens lv318 gene for IPI:IPI00166489.1 GP:AJ242565_1 immunoglobulin heavy chain variable Q.XKPGQAPVLVVYDDSDRPSGIPER.F 3 3.606 0.223 G (96%) region, case 2. Homo sapiens partial mRNA for GP:AJ242730_1 V.SAQAPAQSSSI.N 1 2.216 0.105 O polyhomeotic 2 protein (PH2 gene). Homo sapiens partial oct1 gene for IPI:IPI00171298.1 GP:AJ243995_1 organic cation transporter, exon 1 and M.SNLLAGAACLVMIFISPDL.H 2 3.119 0.283 G, P (96%) joined CDS; oct1_cds. V.LGLLAAGVTLLLPETKGVALPETMK.D 2 2.393 0.279 Homo sapiens mRNA for GP:AJ245054_1 immunoglobulin gamma heavy chain R.VTISVDTSQ.N 1 2.119 0.198 G variable region, partial, clone 1-D16. Homo sapiens mRNA for immunoglobulin gamma heavy chain GP:AJ245209_1 -.EVELVESGGGL.V 1 2.939 0.186 G, O, P variable region, partial, clone 1A- 3G11. -.EVELVESGGGLVQPGGSLR.L 1 3.691 0.137 2 5.827 0.251 3 4.528 0.136 Homo sapiens mRNA for immunoglobulin gamma heavy chain GP:AJ245219_1 K.NQFSLNLK.S 1 2.251 0.113 G variable region, partial, clone 1A- 4G30. Homo sapiens mRNA for immunoglobulin gamma heavy chain GP:AJ245222_1 Q.LVESGGGLVQPGESLR.L 2 4.508 0.397 G variable region, partial, clone 2A- 3G17. Homo sapiens mRNA for immunoglobulin gamma heavy chain GP:AJ245224_1 -.EVQLLESGGALVQPGGSLR.L 2 3.588 1.000 O variable region, partial, clone 2A- 3G21. Homo sapiens mRNA for immunoglobulin gamma heavy chain GP:AJ245229_1 -.EVQLLESGGGLVEPGGSLR.L 1 3.367 1.000 G, O, P variable region, partial, clone 2A- 3G36. 2 5.828 1.000 3 4.243 1.000 E.SGGGLVEPGGSLR.L 2 2.442 0.144 Q.LLESGGGLVEPGGSLR.L 2 3.780 0.278 Homo sapiens mRNA for immunoglobulin gamma heavy chain GP:AJ245230_1 -.GVQLLESGGGLVQPGGSLR.L 2 3.207 0.218 G, O variable region, partial, clone 2A- 3G37. Homo sapiens mRNA for immunoglobulin gamma heavy chain GP:AJ245269_1 -.QAQLVESGGGVVQPGGSLR.L 2 2.947 0.272 G variable region, partial, clone 2A- 3G1.14. Homo sapiens mRNA for GP:AJ245273_1 immunoglobulin mu heavy chain Q.LVESGGGVVRPGR.S 2 2.625 0.121 G variable region, partial, clone 1A-3M1. Homo sapiens mRNA for immunoglobulin mu heavy chain R.AEDTAVYFCAKDLSSSCAYWGQGTLV GP:AJ245307_1 3 3.598 0.113 G variable region, partial, clone 2A- T.V 3M30. Supplementary Table 1 90 Homo sapiens mRNA for immunoglobulin gamma heavy chain GP:AJ245313_1 S.EADGGTTDYAAPVK.G 2 3.978 0.435 G, O variable region, partial, clone 10B- 3G2. Homo sapiens mRNA for immunoglobulin gamma heavy chain GP:AJ245320_1 -.EVQLVESGGALVKPGGSLR.L 2 3.491 1.000 G, O variable region, partial, clone 10B- 3G10. Homo sapiens mRNA for immunoglobulin gamma heavy chain GP:AJ245321_1 -.EEQLVESGGGLVQ.P 2 3.030 0.250 G, P variable region, partial, clone 10B- 3G11. -.EEQLVESGGGLVQPGGSLR.L 2 4.311 0.081 Homo sapiens mRNA for type I IPI:IPI00031909.1 GP:AJ245820_1 I.QVQTLNLSQEE.E 1 2.610 0.187 G, P transmembrane receptor (psk-1 gene). (93%) P.LGLVIVLGSGVYIYYTK.L 2 2.247 0.134 V.ESDFSNPLYEAGDTR.E 2 2.224 0.199 Homo sapiens partial IGHV3-11 gene GP:AJ247652_1 for immunoglobulin heavy chain K.NSLYLEMMSLR.A 2 2.871 0.143 G, O variable region, sequence 9. Homo sapiens partial mRNA for GP:AJ249376_1 immunoglobulin heavy chain variable K.FSYFDLWGR.G 2 2.502 0.273 G region (IGHV gene), clone FRO. Homo sapiens mRNA for gamma N.VAFQQSAHKVLLDDDNLLPLLHLTIEYH IPI:IPI00004389.1 GP:AJ249677_1 tubulin ring complex protein (76p 3 3.847 0.139 O, P GK.E (93%) gene). Homo sapiens partial mRNA for immunoglobulin heavy chain variable region epsilon chain, (IGHV gene, GP:AJ249736_1 -.QVKLLESGGGLVKPGGSLR.L 1 1.951 0.114 G, O anti-Id-BSW17.52H and anti-Id- BSW17.52); anti-Id-BSW17.52H, anti- Id-BSW17.52. Q.VKLLESGGGLVKPGGSLR.L 2 2.877 0.111 V.KLLESGGGLVKPGGSLR.L 2 2.555 0.165 Homo sapiens partial IgG2 gene for IPI:IPI00168728.1 GP:AJ250170_1 immunoglobulin heavy chain constant Q.FNWYVDGMEVHNAK.T 1 2.070 0.147 G (95%) region IgG2, exons 1-4. Homo sapiens partial mRNA for GP:AJ253041_1 immunoglobulin heavy chain E.IHPSGSTNYNPSLK.S 2 2.948 0.113 G (IGH2bM35a gene). Homo sapiens partial mRNA for GP:AJ253048_1 immunoglobulin heavy chain W.IGNIDQSGSANYNPSLK.S 2 3.112 0.117 G (IGH1dM41 gene). Homo sapiens partial mRNA for GP:AJ253101_1 immunoglobulin heavy chain R.VTLSLDTSK.N 1 2.134 1.000 G (IGH5cA68 gene). Homo sapiens mRNA for immunoglobulin gamma heavy chain GP:AJ271548_1 W.INPNSGDTNYAQK.F 2 3.099 0.379 G, O, P variable region, IGHV1-02 gene, clone MGgis16b. Homo sapiens partial mRNA for immunoglobulin gamma heavy chain GP:AJ271600_1 -.EVQLLESGGGLVQPGESLR.L 2 4.223 0.250 G, O variable region (IGHVDJ gene), patient ARD. Homo sapiens partial mRNA for immunoglobulin gamma heavy chain GP:AJ271603_1 K.DTLYLQMSSLR.A 1 1.812 0.095 G variable region (IGHVDJ gene), patient LER. Homo sapiens mRNA for chromosome IPI:IPI00173512.1 GP:AJ272204_1 L.FRKLKDETEAGETDS.A 2 2.617 0.098 O, P 12 open reading frame 3 (C12orf3). (96%) T.FEERLILK.A 1 1.865 0.082 Homo sapiens mRNA for calcium IPI:IPI00020081.1 GP:AJ272213_1 channel alpha2-delta3 subunit (splice W.MACANKGFFTQISTLADVQE.N 2 2.662 0.172 O, P (96%) variant). Homo sapiens partial mRNA for IPI:IPI00020635.3 GP:AJ272267_1 P.FRGKELQPGSHIQSDKEIDAFVR.A 2 2.361 0.250 G, O choline dehydrogenase (chdh gene). (98%) W.MDMTIHEGKRW.S 2 2.825 0.108 Homo sapiens mRNA for stabilin-1 IPI:IPI00216749.1 GP:AJ275213_1 A.HFLQGALFEEELARLGGQEVATLN.P 2 2.419 0.169 G, P (stab1 gene). (96%) P.CWPSPCSLLAQCSVSPKGQA.Q 2 2.659 0.175 V.QRHLPFEGGLAYGIDQLLE.P 2 2.643 0.090 Homo sapiens partial IGVL3 gene for GP:AJ275364_1 immunoglobulin lambda light chain V R.FSGSNSGNTATLTISGV.E 2 4.489 0.499 G, O, P region, case 1, clone 9. GP:AJ275373_1 Homo sapiens partial IGVH3 gene for N.TVKYADSVK.G 1 2.256 0.188 G Supplementary Table 1 91 immunoglobulin heavy chain V region, case 1, clone 18. Homo sapiens partial IGVH3 gene for GP:AJ275377_1 immunoglobulin heavy chain V region, T.TYYAASVK.G 1 1.911 0.205 G case 1, cell Mo IV 35. Homo sapiens partial IGVL1 gene for GP:AJ275387_1 immunoglobulin lambda light chain V D.TVNWYQQVPGTAPK.L 2 2.735 0.342 G region, case 1, cell Mo IV 136. N.IGSDTVNWYQQVPGTAPK.L 2 3.881 0.330 Homo sapiens partial IGVL3 gene for GP:AJ275426_1 immunoglobulin lambda light chain V K.LLIYSDNQR.P 2 2.869 0.082 G, P region, case 2, clone 5. K.LLIYSDNQRPSGVPDR.F 2 2.925 0.112 Homo sapiens mRNA for ASPIC IPI:IPI00018073.1 GP:AJ276171_1 (acidic secreted protein in cartilage) R.DVAAEAGVSK.Y 1 2.245 0.348 O (95%) (ASPIC1 gene). Homo sapiens mRNA for matrix extracellular phosphoglycoprotein IPI:IPI00168308.1 GP:AJ276396_1 (MEPE gene); secreted from K.DIQTGFAGPSEAESTHLDTKKP.G 2 2.698 0.151 A, G (99%) oncogenic hypophosphataemic tumours. T.RKGVDHSNRNQATLNEKQR.F 2 2.486 0.138 Homo sapiens partial TTN gene for IPI:IPI00145902.1 GP:AJ277892_1 A.ENIVGIGKPSKVSECF.V 2 2.589 0.204 A, G, O, P titin; Titin heart Isoform. (97%) A.RILTKPR.S 1 1.819 0.149 E.TFVLEADIRGKPIPDVV.W 2 2.652 0.118 F.GVSLTWEPPEYDGGAEITNYV.I 2 2.964 0.100 F.SPPSPPGKPVVTDITEN.A 2 2.720 0.132 G.YHLEYK.E 1 2.181 0.099 I.VVEKPGRIVPGVIGLMR.A 2 2.236 0.103 P.AFDGGSK.I 1 2.141 0.134 P.LKVTGVTAEKCYLAWNPPL.Q 2 2.769 0.205 R.KLLPERKPEPKE.E 1 2.976 0.110 V.MVKVLDSPGPCGKLTVSR.V 1 2.185 0.123 Homo sapiens partial TTN gene for IPI:IPI00025806.1 GP:AJ277892_3 E.VIKKAVPEAPTPVPKK.V 1 2.761 0.220 A, G, O, P titin; Titin Isoform from M.Soleus. (99%) F.ITEEEVVPVIPVKVPEVPRKPVPEEKKP 3 3.569 0.097 VPVPKK.K G.TPELSAK.W 1 1.936 0.225 L.HSGAARSVWKDDTSTSLELFAAKA.T 2 2.581 0.112 Q.EPAQIVEK.A 1 1.902 0.092 Q.KEKEAVYEKK.Q 1 2.015 0.122 Q.QAIPDSTVEFKA.I 2 2.501 0.161 S.VGELIVKEPAKIIERAELIQVTAGDPATL 2 2.688 0.120 EYTV.A V.LGSSIHMECKVSGSLPISAQWFK.D 2 2.308 0.187 V.PKKPVPEEKKPVPVPKKEPAAPPKVPE 3 4.203 0.138 V.P V.SGGSCYITKEALESSLELYLVK.T 2 2.362 0.174 Homo sapiens partial TTN gene for GP:AJ277892_6 T.KPKLAKVPEPPKKV.V 1 2.792 0.081 A titin; partial PEVK Titin fetal Isoform. Homo sapiens mRNA for calsyntenin- IPI:IPI00005491.1 GP:AJ278018_1 D.ATNSTAGYSIYGVGSMSR.Y 2 2.855 0.141 G, P 2 (CS2 gene). (93%) Homo sapiens partial mRNA for GP:AJ278148_1 N.KDPILEF.W 1 2.365 0.113 P oxodicarboxylate carrier (ODC gene). Homo sapiens mRNA for Tsg24 IPI:IPI00218890.1 GP:AJ278357_1 A.VYKAFTVDSPVQ.Q 2 2.557 0.118 G protein. (99%) G.GDMCVHAYLSGQPLEESQLSMLACF.L 3 4.123 0.153 Homo sapiens partial mRNA for GP:AJ278475_1 transport-secretion protein 2.1 (TTS- K.IIRSFLLKVLPADSHEHA.S 2 2.703 0.085 P 2.1 gene). Homo sapiens VH3 gene for anti- G.RVGRTSGSYYFDYWGQGTPVTVSSAS GP:AJ278772_1 testosterone immunoglobulin heavy 2 2.940 0.274 A, G, P TK.G chain variable region, clone TA7. 3 3.985 0.208 P.VTVSSASTKGPK.L 1 1.983 0.140 2 3.255 0.270 W.GQGTPVTVSSASTKGPK.L 2 3.237 0.215 Homo sapiens mRNA for GP:AJ279530_1 immunoglobulin mu heavy chain K.GLEWIGEINHSGNTNCNPSLK.S 2 3.861 0.145 G variable region, partial, clone
Supplementary Table 1 92 CD27high-11. Homo sapiens partial IGHV gene for GP:AJ289262_1 immunoglobulin heavy chain variable L.NDWDDDKYYSTSLK.T 2 3.517 0.340 G, P region, clone A65. Homo sapiens partial IGHV gene for IPI:IPI00007893.1 GP:AJ289345_1 immunoglobulin heavy chain variable G.IIPILGLANYAQK.F 2 3.550 0.308 G (95%) region, clone B34. I.PILGLANYAQK.F 2 2.966 0.227 Homo sapiens partial IGHV gene for GP:AJ289417_1 immunoglobulin heavy chain variable R.SISTAYLQLNSLK.A 2 3.784 0.104 G region, clone PB40. Homo sapiens mRNA for chromosome GP:AJ291678_1 8 open reading frame 14 (C8orf14); L.QVSPGSLTFHSLSLR.S 2 2.703 0.120 O c8ORF14. Homo sapiens mRNA for G6b-A IPI:IPI00059300.1 GP:AJ292259_1 R.AQGNPGASLDGRPGDRV.N 2 2.868 0.095 P protein (G6B gene), isoform A. (94%) Homo sapiens partial LBVL3A gene GP:AJ292950_1 for immunoglobulin lambda light chain, R.ISGSNSGNTATLTISR.V 2 3.964 0.315 G, O exon 1. Homo sapiens IGLV gene for immunoglobulin anti-GrB light chain GP:AJ293741_1 N.IGSNTVNWYQQVPGTAPK.L 2 3.726 0.393 G variable region, clone GP92; VL1 gene family. Homo sapiens partial mRNA for IPI:IPI00004608.1 GP:AJ294731_1 immunoglobulin heavy chain constant L.MISRTPEVTWVVVDVSHEDPEVQ.F 2 3.137 0.222 G (94%) region gamma 2 (IGHG2 gene). 3 4.150 0.264 T.PEVTWVVVDVSHEDPEVQ.F 2 3.794 0.304 Homo sapiens partial mRNA for IPI:IPI00004618.1 GP:AJ294733_1 immunoglobulin heavy chain constant A.VEWESNGQPEDNYK.T 1 2.417 0.223 A, G, O, P (93%) region gamma 4 (IGHG4 gene). 2 2.833 0.150 D.IAVEWESNGQPEDNYK.T 2 4.044 0.462 E.SNGQPEDNYK.T 1 1.951 0.177 F.YPSDIAVEWESNGQPEDNYK.T 2 4.780 0.441 G.FYPSDIAVEWESNGQPEDNYK.T 2 3.471 0.354 I.AVEWESNGQPEDNYK.T 2 3.274 0.388 K.GFYPSDIAVEWESNGQPED.N 2 3.536 0.302 K.GFYPSDIAVEWESNGQPEDN.Y 2 4.258 0.177 K.GFYPSDIAVEWESNGQPEDNYK.T 2 5.382 0.351 3 5.631 0.330 Q.PEDNYK.T 1 2.177 0.082 S.DIAVEWESNGQPEDNYK.T 2 2.758 0.199 W.ESNGQPEDNYK.T 1 2.614 0.242 Y.PSDIAVEWESNGQPEDNYK.T 2 5.174 0.500 Homo sapiens partial IGVH3 gene for GP:AJ295970_1 immunoglobulin heavy chain variable K.NSLYLQMSSLTA.E 2 2.572 0.164 O region, isolate case 2, cell G41. Homo sapiens partial IGVH3 gene for GP:AJ295979_1 immunoglobulin heavy chain variable R.AEDTAIYYCVRDSPCCRD.G 2 2.807 0.083 G region, isolate case 2, cell G131. IPI:IPI00152292.1 GP:AJ296101_1 Homo sapiens mRNA for artemis. A.RMELLHSGGRVK.D 2 2.388 0.103 A (99%) F.EVPSTPEAE.L 1 2.071 0.209 Homo sapiens mRNA for putative IPI:IPI00176956.1 GP:AJ296290_1 L.PITMAAGITQP.L 1 2.448 0.122 O protein kinase (WNK1 gene). (95%) Homo sapiens partial mRNA for T-cell receptor beta chain (TCRBV8J1S5 GP:AJ296362_1 Y.FCASSLGVGPNQPQHFGDGTR.L 2 2.531 0.101 P gene); sequence includes N-D-N joining region (CDR3). Homo sapiens mRNA for CDC2L5 E.HAPSPSSGGTLKNDKAKTKPPLQVTKV IPI:IPI00028272.1 GP:AJ297709_1 protein kinase, (CDC2L5 gene), 2 3.132 0.132 O, P E.N (92%) isoform 1; isoform 1. E.IVTDKEDALDFKKDK.G 2 2.296 0.155 L.LGGASAATAATAAGGTGGSGGSPASS 2 2.409 0.244 SGTQR.R Homo sapiens partial mRNA for GP:AJ298038_1 immunoglobulin variable light chain, N.IGDNYVSWYQQLPGTAPK.L 2 4.249 0.452 G clone H6502. Homo sapiens partial mRNA for GP:AJ298039_1 immunoglobulin variable light chain, R.LLIYDDDKR.P 2 2.670 0.314 G clone F9453.
Supplementary Table 1 93 Homo sapiens partial mRNA for GP:AJ298046_1 immunoglobulin variable light chain, K.APNLLIYDASNLETGVPSR.F 2 3.633 0.404 O clone A6452. Homo sapiens partial mRNA for GP:AJ298051_1 immunoglobulin variable light chain, K.PGQAPVLVIYE.D 1 2.235 0.202 G clone C750his. 2 3.084 0.326 Homo sapiens partial IGVH5-51 gene for immunoglobulin heavy chain GP:AJ298449_1 E.SLSTAYLQWSSLK.A 1 2.577 0.306 G, P variable region, patient 1, small EBER+ cell isolate 2.27. 2 4.036 0.351 Homo sapiens partial IGVKL2 gene for immunoglobulin kappa chain variable GP:AJ298488_1 R.LLIYSASTR.V 1 2.136 0.162 G region, patient 1, small EBER+ cell isolate 2.43. Homo sapiens partial IGVKA19/3 gene for immunoglobulin kappa chain IPI:IPI00178045.1 GP:AJ298508_1 R.ASGVPDRFSGSGSGTDFTLQ.I 2 3.995 0.463 A, G, O, P variable region, patient 3, small (96%) EBER+ cell isolate 648. R.FSGSGSGTDFTLQ.I 1 2.926 0.258 2 3.970 0.319 R.FSGSGSGTDFTLQISR.V 2 2.669 0.143 Homo sapiens partial IGVL3h gene for immunoglobulin lambda chain variable GP:AJ298545_1 K.PGQAPVLVVFDDSDRPSGIPER.F 2 3.435 0.253 G region, patient 3, small EBER+ cell isolate 647. 3 4.136 0.437 Q.QKPGQAPVLVVFDDSDRPSGIPER.F 2 2.936 0.184 Homo sapiens partial IGVL2a2 gene for immunoglobulin lambda chain GP:AJ298546_1 K.LMIYDVANRPSGVSDR.F 2 2.678 0.164 G variable region, patient 3, small EBER+ cell isolate 703. Homo sapiens partial IGVL2e gene for immunoglobulin lambda chain variable GP:AJ298549_1 K.LMIYDVGKRPSGVPDR.F 2 2.554 0.236 G region, patient 3, small EBER+ cell isolate 708. Homo sapiens mRNA for immunoglobulin gamma heavy chain IPI:IPI00220120.1 GP:AJ298610_1 -.EVQLLESGGGLVR.P 2 3.211 0.258 G variable region (IGHV3-23 gene), (91%) clone shgi55, SLE patient. Homo sapiens mRNA for immunoglobulin kappa variable region IPI:IPI00026195.1 GP:AJ298618_1 R.FSGSGSGTDFTLR.I 1 2.268 0.251 G, O, P (IGKV2 gene), clone shli58, SLE (93%) patient; rearrange. 2 3.797 0.217 Homo sapiens partial mRNA for immunoglobulin gamma heavy chain GP:AJ300806_1 variable region (IGHV3-15), clone Q.TEDTAVYYCTTDSK.Y 2 2.737 0.092 G M2u-05 (m2hoe05), Kawasaki disease patient. Homo sapiens partial BV6S7J1.3 GP:AJ301503_1 gene for T-cell receptor beta chain VJ P.RINSGNTIYFGEGI.G 1 2.139 0.091 G region, patient A6, 214 BP. Homo sapiens 6M1-4P*02 gene for IPI:IPI00161295.1 GP:AJ302565_1 G.FSNWPHLEVVLFVVILIF.Y 2 3.004 0.147 O olfactory receptor, cell line KR3598. (94%) Homo sapiens partial mRNA for GP:AJ303368_1 chr415 synaptotagmin (CHR415SYT M.LSVYNKSSMRR.K 2 2.565 0.198 O gene). Homo sapiens mRNA for sodium/calcium exchanger SCL8A3, IPI:IPI00163279.1 GP:AJ304852_1 alternative splice form A (SCL8A3 C.HGWACFAVSILIIGMLTAI.I 2 2.543 0.328 A, O (96%) gene); alternative splice form A, (exons 2, 3, 5, 9, 10, 11, 12). V.DYKTEDGSANAGADYE.F 2 2.414 0.111 Homo sapiens partial IGHV gene for GP:AJ305186_1 immunoglobulin heavy chain variable F.SNYGFHWVR.Q 2 2.528 0.233 G, P region, rearrangement D12IIIVH3H7. S.NYGFHWVR.Q 2 2.450 0.188 Homo sapiens partial IGHV gene for GP:AJ305206_1 immunoglobulin heavy chain variable Y.YYMDVWGKGPRSRR.- 2 2.834 0.118 P region, rearrangement D12IVVH3E1. Homo sapiens mRNA for GP:AJ305232_1 immunoglobulin heavy chain variable D.PMMAVAGYLDYWGQGTLVTVS.S 2 3.949 0.102 O, P region V(D)J-rearrangement (IGHV Supplementary Table 1 94 gene), patient 11. Y.LDYWGQGTLVTVSSASPTSPK.V 2 4.424 0.428 Homo sapiens mRNA for activating IPI:IPI00009765.1 GP:AJ305370_1 S.LILLVSQGVLLK.C 1 2.034 0.131 G, O coreceptor NKp80 (ML/KLRF1 gene). (94%) 2 2.772 0.088 Homo sapiens partial mRNA for anti- DNA immunoglobulin heavy chain GP:AJ306675_1 K.NSVYLQMDSLR.P 2 2.509 0.299 G variable region (IGHV-R4C9 gene); Anti-DNA Fab. Homo sapiens partial mRNA for anti- DNA immunoglobulin heavy chain GP:AJ306680_1 R.QAPGQGLEWMGGIIPLFGTTN.Y 2 3.473 0.285 G variable region (IGHV-R5C9 gene); Anti-DNA Fab. Homo sapiens partial mRNA for anti- DNA immunoglobulin heavy chain GP:AJ306681_1 K.DTLYLQMNSLKAEDTAIYYCA.R 2 2.802 0.179 G, P variable region (IGHV-P212 gene); Anti-DNA Fab. Q.LAQSGGGLVKPGGSLR.V 2 3.195 0.320 Tetraodon nigroviridis aw502783-like gene (partial), af290615-like gene, ak000823-like gene, vav-3 gene, GP:AJ308233_2 amylase-1 gene, amylase-2 gene and Q.KLTPYPASSLL.I 1 2.013 0.126 G amylase-3 gene; Alignments with human AF290615, BC003106 and AF047439 cDNAs. Homo sapiens partial mRNA for IPI:IPI00009792.1 GP:AJ308447_1 immunoglobulin heavy chain variable A.MVPRLSYWGQGTLVTVSSASTK.G 2 3.966 0.240 G (93%) region (IGHV1 gene), clone EBB10. 3 3.716 0.294 Homo sapiens partial mRNA for GP:AJ308449_1 immunoglobulin heavy chain variable R.VDYWGQGTLVTVSSASTK.G 2 2.614 0.103 G region (IGHV4 gene), clone EBG10. Homo sapiens partial mRNA for GP:AJ308451_1 immunoglobulin heavy chain variable -.AVQLVQSGGGLVKPGGSLR.L 2 3.787 0.311 G, O region (IGHV3 gene), clone EBE12. Homo sapiens partial mRNA for IPI:IPI00166489.1 GP:AJ308454_1 immunoglobulin light chain variable R.LSGSNSGNTATLTISR.V 2 3.908 0.316 G, O (92%) region (IGLV3 gene), clone EBG10. S.YELTQPPSVSVAPGQ.T 2 3.747 0.368 Homo sapiens partial mRNA for IPI:IPI00166489.1 GP:AJ308455_1 immunoglobulin light chain variable K.SVHWYQQKPGQAPVLVIYYHND.R 2 3.752 0.288 G (92%) region (IGLV3 gene), clone EBA11. Homo sapiens partial mRNA for GP:AJ308456_1 immunoglobulin light chain variable -.QPVLTQPPSASGTPGQR.V 2 2.790 0.116 G region (IGLV1 gene), clone EBB10. Homo sapiens mRNA for leucine-rich IPI:IPI00065256.2 GP:AJ308569_1 repeat-containing 2 protein (LRRC2 R.SSAFVFE.L 1 2.215 0.082 A (99%) gene). Homo sapiens mRNA for keratin 6 irs (KRT6IRS gene); type II cytokeratin GP:AJ308599_1 R.FLEQQNQVLETK.W 1 2.734 0.117 G, P specific to the inner root sheath of the hair follicle. 2 2.671 0.209 Homo sapiens partial IGHV3 gene for GP:AJ309825_1 immunoglobulin G heavy chain K.KSLYLKMN.S 1 2.342 0.136 G variable region. K.KSLYLKMNSLR.A 2 3.995 1.000 Homo sapiens partial mRNA for GP:AJ309826_1 variable part of immunoglobulin A Q.GTTVTVSSASPTSPK.V 1 2.332 0.264 A, O, P heavy chain (IGVH3 gene). 2 4.536 0.323 Homo sapiens mRNA for SMC5 IPI:IPI00167153.1 GP:AJ310550_1 V.KRGCSRGMVEIELFRASGNLVI.T 2 2.932 0.170 O protein. (95%) Homo sapiens mRNA for SMC6 IPI:IPI00033897.1 GP:AJ310551_1 E.VEKSASILDK.E 1 2.600 0.124 P protein. (96%) L.RMSDPERGQTTLPFR.P 2 2.841 0.088 Homo sapiens mRNA for hypthetical GP:AJ311122_1 A.AHLDDAAKMPSASSGEE.A 2 2.458 0.137 A, G protein (ORF1). L.DDAAKMPSASSGEEADAG.S 2 2.413 0.188 Homo sapiens mRNA for putative IPI:IPI00102575.2 GP:AJ314648_1 A.SSQRSGRQILSQLKEAT.Q 2 2.707 0.119 O ATP/GTP-binding protein; ORF1. (94%) V.PSETVDEIVKSGYISESENS.E 2 2.710 0.091 Homo sapiens mRNA for cyclin B3 IPI:IPI00066473.1 GP:AJ314764_1 K.EEPTIEDETLI.N 1 2.658 0.140 G (CCNB3 gene). (93%)
Supplementary Table 1 95 Homo sapiens mRNA for putative N- IPI:IPI00171630.1 GP:AJ314788_1 P.KFAEHGETLAMKGLTLNCLGK.K 2 2.692 0.141 G acetyltransferase. (95%) Homo sapiens mRNA for zinc finger IPI:IPI00186406.1 GP:AJ319673_1 K.ELLLPQDAGGPTSLGGGA.G 1 1.961 0.134 A protein RINZF (RINZF gene). (92%) Homo sapiens mRNA for axonemal IPI:IPI00061170.1 GP:AJ320497_1 beta heavy chain dynein type 11 F.MKHFLLYGHAVSSDEMDA.H 2 2.682 0.101 O, P (96%) (DNAH11 gene). R.LAASQEIPRDANHK.L 2 2.615 0.131 Homo sapiens mRNA for putative IPI:IPI00103745.1 GP:AJ320508_1 autophagy-related cysteine F.DEWNSLAVYVSMDNTV.V 1 2.403 0.090 A, G (96%) endopeptidase 2 (AUTL2 gene). L.IVPLRLGINQINPVYVDAFKECFKMP.Q 3 3.759 0.160 Homo sapiens mRNA for junctional IPI:IPI00152850.1 GP:AJ344431_1 K.EIDEIVIELTVQVKPVTPVCR.V 2 2.327 0.134 G, P adhesion molecule-2 (JAM-2 gene). (92%) L.YRCEVVARNDRKE.I 2 2.584 0.120 Homo sapiens partial IGVKL12 gene GP:AJ347539_1 for immunoglobulin kappa chain K.ASNLKSGVPSR.F 1 1.895 0.161 G variable region, isolate case1-cell152. 2 3.461 1.000 Homo sapiens partial IGVKA19/3 GP:AJ347556_1 gene for immunoglobulin kappa chain R.SSQSLLHSDGYNYLDWYLQK.P 2 4.747 0.466 G variable region, isolate case2-cell31. R.SSQSLLHSDGYNYLDWYLQKPGQSPQ 2 4.121 0.423 .P Homo sapiens partial IGVKB3 gene IPI:IPI00026197.1 GP:AJ347557_1 for immunoglobulin kappa chain K.XLIYWASTR.E 1 2.138 0.154 G, P (98%) variable region, isolate case2-cell29. 2 3.196 0.216 Homo sapiens partial IGVKL2 gene for IPI:IPI00007884.1 GP:AJ347564_1 immunoglobulin kappa chain variable T.LSCRASQSVSSNLAR.Y 2 2.910 0.153 P (92%) region, isolate case2-cell156. Homo sapiens partial IGVKLFVK431 IPI:IPI00161229.1 GP:AJ347565_1 gene for immunoglobulin kappa chain S.NYLTWYQQK.P 2 2.805 0.213 G (94%) variable region, isolate case2-cell152. Homo sapiens partial IGVKO12/2 IPI:IPI00053682.1 GP:AJ347580_1 gene for immunoglobulin kappa chain R.ASQSISSYINWYQQK.P 2 2.541 0.341 G, O (94%) variable region, isolate case2-cell194. R.ASQSISSYINWYQQKPGK.A 2 4.409 0.285 S.SYINWYQQK.P 2 2.441 0.105 S.YINWYQQK.P 1 2.283 0.161 2 2.322 0.143 S.YINWYQQKPGK.A 2 3.115 1.000 Y.INWYQQK.P 1 2.160 0.145 Homo sapiens partial IGVKB3 gene GP:AJ347591_1 for immunoglobulin kappa chain K.NYLAWYQQRPGQPPK.L 2 2.666 0.322 G variable region, isolate case3-cell18. Homo sapiens partial IGVKA27 gene IPI:IPI00030206.1 GP:AJ347611_1 for immunoglobulin kappa chain R.ASQSVSSSHLAWYQQKPGQAPR.L 2 3.777 0.141 G (94%) variable region, isolate case9-cell27. Homo sapiens partial IGVKA27 gene GP:AJ347616_1 for immunoglobulin kappa chain R.FSGSGSGTDFTLTVSR.L 2 3.859 0.495 G variable region, isolate case9-cell401. Homo sapiens partial IGVKA27 gene GP:AJ347623_1 for immunoglobulin kappa chain A.SQSVKNNYLAWYQQK.P 2 2.791 0.128 G variable region, isolate case9-cell385. A.SQSVKNNYLAWYQQKPGQAPR.L 2 2.748 0.170 Homo sapiens partial IGVKL12 gene IPI:IPI00003457.1 GP:AJ347632_1 for immunoglobulin kappa chain R.ASQNIDSWLAWYQQK.P 2 2.934 0.352 G (91%) variable region, isolate case9-cell163. S.YSPLTFGGGTK.V 1 1.807 0.271 Homo sapiens partial IGVL2e gene for GP:AJ347642_1 immunoglobulin lambda chain variable V.IERPSGVPDR.F 2 2.810 0.179 G, P region, isolate case1-cell70. Homo sapiens partial IGVL1b gene for GP:AJ347666_1 immunoglobulin lambda chain variable N.IGNDYVSWYQQLPGTAPK.L 2 4.445 0.412 G region, isolate case3-cell36. Homo sapiens partial IGVL1g gene for IPI:IPI00045547.1 GP:AJ347669_1 immunoglobulin lambda chain variable L.PGTAPKLLLYK.N 1 2.215 0.130 G (92%) region, isolate case3-cell24. Homo sapiens partial IGVL3h gene for IPI:IPI00166489.1 GP:AJ347691_1 immunoglobulin lambda chain variable D.HLYVFGTGTK.V 1 2.284 0.095 G (92%) region, isolate case9-cell429. Homo sapiens partial IGVL2b2 gene GP:AJ347697_1 G.YDLVSWYQQHPGKAPK.V 2 3.600 0.351 A, G for immunoglobulin lambda chain Supplementary Table 1 96 variable region, isolate case9-cell341. R.FSGSKSGNTAL.L 1 1.973 0.138 Homo sapiens partial IGVL3r gene for GP:AJ347698_1 immunoglobulin lambda chain variable K.YGCWYQQK.P 1 2.190 0.108 G region, isolate case9-cell337. Homo sapiens partial IGVL3l gene for GP:AJ347699_1 immunoglobulin lambda chain variable K.PGQAPLLVLYGK.T 1 2.468 0.271 G region, isolate case9-cell331. Homo sapiens partial mRNA for GP:AJ388640_1 immunoglobulin kappa chain variable Q.QYNRFSWTFGQGTKV.E 1 2.859 0.089 O region (IGVK gene), sample GN01. Homo sapiens partial mRNA for GP:AJ388644_1 immunoglobulin kappa chain variable -.AIQMTQSPSSLSASVGDR.V 1 2.234 0.262 G, O, P region (IGVK gene), sample GN05. 2 5.749 0.452 Homo sapiens partial mRNA for GP:AJ388645_1 immunoglobulin kappa chain variable -.DIQMTQSPSTLSAF.V 2 3.781 0.416 G region (IGVK gene), sample GN06. Homo sapiens partial mRNA for IPI:IPI00178045.1 GP:AJ388646_1 immunoglobulin kappa chain variable M.QALQTPLTFGGGTK.V 2 2.591 0.111 G (98%) region (IGVK gene), sample GN07. M.QALQTPLTFGGGTKV.E 2 3.146 0.242 Q.ALQTPLTFGGGTKV.E 2 2.500 0.129 Homo sapiens partial mRNA for IPI:IPI00178045.1 GP:AJ388650_1 immunoglobulin kappa chain variable M.QALQTLFTFGPGTK.V 1 2.198 0.187 G (98%) region (IGVK gene), sample GN18. Homo sapiens partial mRNA for GP:AJ388654_1 immunoglobulin kappa chain variable -.ESVLTQSPATLSLSPGER.V 2 3.258 0.341 O, P region (IGVK gene), sample GN27. Homo sapiens partial mRNA for GP:AJ388656_1 immunoglobulin kappa chain variable -.DIQVTQSPSSLSA.S 1 2.479 0.310 G, O, P region (IGVK gene), sample GN29. 2 4.067 0.329 -.DIQVTQSPSSLSASVGDR.V 2 5.432 0.607 Q.VTQSPSSLSASVGDR.V 2 2.749 0.183 Homo sapiens partial mRNA for GP:AJ389174_1 immunoglobulin heavy chain variable L.SLTCSVSGGSISSYYWSWI.R 2 3.063 0.214 G region (IGVH gene), sample GN06. Homo sapiens partial mRNA for GP:AJ389181_1 immunoglobulin heavy chain variable R.LTITADK.S 1 2.063 0.166 G region (IGVH gene), sample GN14. Homo sapiens partial mRNA for IPI:IPI00182107.1 GP:AJ389182_1 immunoglobulin heavy chain variable -.DVQLVESGGGLVQPGGSLR.L 2 4.928 1.000 G, O, P (93%) region (IGVH gene), sample GN15. Homo sapiens IGVH gene for IPI:IPI00018563.3 GP:AJ389918_1 immunoglobulin heavy chain variable R.YSPSFQGQVTISADR.S 2 2.703 0.387 G (92%) region (VH5 family), cell 139. Homo sapiens IGVH gene for immunoglobulin heavy chain variable GP:AJ389930_1 S.KIDGETTDYAAPVK.G 2 2.842 0.090 G region (VH3 family), cell 196; out-of- frame rearrangement. Homo sapiens IGHG3 gene for immunoglobulin heavy chain gamma 3 GP:AJ390272_1 N.IFSCSVMHEALHNHYTQK.S 2 2.584 0.188 G constant region, 3-exon hinge, isolate Mand-231. Homo sapiens partial mRNA for thyroid peroxidase specific GP:AJ399801_1 -.EVQLVQSGAEVR.K 1 3.000 0.335 G, O, P immunoglobulin heavy chain variable region (IGHV gene), clone A1. 2 4.022 0.260 Homo sapiens partial mRNA for thyroid peroxidase-specific GP:AJ399811_1 -.EVQLVESAGGLVQPGGSLR.L 1 2.695 1.000 G immunoglobulin heavy chain variable region (IGHV gene), clone A12. 2 3.436 1.000 3 3.561 0.106 K.NTLYLQMGSLRT.E 2 2.855 0.134 Homo sapiens partial mRNA for thyroid peroxidase-specific GP:AJ399814_1 -.LVQLVQSGAEVK.K 1 3.049 0.144 A, G, O, P immunoglobulin heavy chain variable region (IGHV gene), clone A16. 2 4.077 0.282 -.LVQLVQSGAEVKKPGASVK.V 2 3.807 0.224 GP:AJ399815_1 Homo sapiens partial mRNA for R.QAPGQGLEWMGGIIPIFRTT.N 2 2.777 0.264 G Supplementary Table 1 97 thyroid peroxidase-specific immunoglobulin heavy chain variable region (IGHV gene), clone A17. Homo sapiens partial mRNA for thyroid peroxidase-specific GP:AJ399829_1 -.EVQLVESGAEVR.R 2 2.834 0.213 P immunoglobulin heavy chain variable region (IGHV gene), clone T3. Homo sapiens partial mRNA for thyroid peroxidase-specific GP:AJ399836_1 -.EDQLVESGGGLVQPGGSLR.L 2 3.368 0.169 G, O immunoglobulin heavy chain variable region (IGHV gene), clone T10. Homo sapiens partial mRNA for thyroid peroxidase-specific GP:AJ399866_1 K.LIIYEVNK.R 1 1.982 0.102 G immunoglobulin lambda chain variable region (IGLV gene), clone T4. Homo sapiens partial mRNA for thyroid peroxidase-specific GP:AJ399874_1 A.SQSVTQWLAWYQQKPGKAPR.L 2 2.652 0.100 G immunoglobulin kappa chain variable region (IGKV gene), clone T5. W.LAWYQQKPGKAPR.L 2 3.853 1.000 Homo sapiens partial mRNA for thyroid peroxidase-specific IPI:IPI00024136.1 GP:AJ399878_1 R.ASQSVSSTYLAWYQQKPGQAPR.L 2 3.510 0.138 G immunoglobulin kappa chain variable (97%) region (IGKV gene), clone T10. Homo sapiens partial mRNA for thyroid peroxidase-specific GP:AJ399879_1 -.EIVLTQSHPSLSASVGDR.V 2 4.055 0.156 G, O, P immunoglobulin kappa chain Vvariable egion (IGKV gene), clone T11. I.YAASSLQSGVPLRFSGSGSGTDFTL.T 2 2.492 0.112 Homo sapiens L12a-Jk1 gene for IPI:IPI00003457.1 GP:AJ399903_1 immunoglobulin kappa I chain, clone S.WLAWYQQEPGK.A 1 2.327 0.135 G (97%) FO 118. Homo sapiens A30-Jk4 gene for GP:AJ399920_1 immunoglobulin kappa I chain, clone R.FSGSGSGTEFTLR.V 2 2.967 0.307 G FJ 12. Homo sapiens 2b2.400B5-JL2/3a GP:AJ399978_1 gene for immunoglobulin lambda II L.VSWYQQHPGQ.A 2 3.123 0.251 G, O chain, clone FL 6, FL 9. R.LVSWYQQHPGQ.A 1 2.000 0.120 2 2.521 0.311 Homo sapiens ASCL3 gene, CEGP1 C.SHICKEAPRGSVACECRPGFELAKNQ IPI:IPI00173436.1 GP:AJ400877_1 gene, C11orf14 gene, C11orf15 gene, 2 2.668 0.139 G, O R.D (97%) C11orf16 gene and C11orf17 gene. F.LSDNQHTCIHRSEEGL.S 1 2.018 0.127 Homo sapiens ST5 gene for suppression of tumorigenicity 5, L27a GP:AJ400879_1 E.EPAGGASVSAGSRAVGVAGVAGEA.G 2 2.523 0.145 A, P gene for ribosomal protein L27a and KIAA0298 gene. S.QMFAGFIQDR.E 2 2.566 0.237 Homo sapiens partial IGHV5 gene for IPI:IPI00018563.3 GP:AJ402387_1 immunoglobulin heavy chain variable K.GLEWMGIIYPADSDTR.Y 2 3.525 0.446 G (94%) region, donor KH, 30. Homo sapiens partial IGHV3 gene for IPI:IPI00145980.1 GP:AJ402404_1 immunoglobulin heavy chain variable V.VPAAIPSIY.R 1 2.303 0.151 O (97%) region, donor HH, 45. Homo sapiens partial IGHV3 gene for GP:AJ402407_1 immunoglobulin heavy chain variable S.SGGSTYFSDSVK.G 2 2.536 0.279 G region, donor HH, 67. Homo sapiens partial IGHV3 gene for GP:AJ402410_1 immunoglobulin heavy chain variable K.SQTDGGTTDYAAPVK.G 2 4.510 0.385 G, O, P region, donor HH, 89. Homo sapiens partial IGHV3 gene for GP:AJ402417_1 immunoglobulin heavy chain variable K.GLEWVAVISSDGSKKYYADSVK.G 2 2.927 0.114 G region, donor HH, 30. Homo sapiens partial IGHV4 gene for GP:AJ402420_1 immunoglobulin heavy chain variable K.NKFSLK.V 1 1.913 1.000 G region, donor HH, 22. Homo sapiens partial bv13s3bj2.1 S.VYFCASSEIVSATRGNEQFFGPGTRLT GP:AJ406155_1 3 3.629 0.227 P gene for T-cell receptor beta chain. VLGKKGAPGGR.E Homo sapiens partial VH3-11 gene for rearranged immunoglobulin heavy GP:AJ406598_1 R.FVYYADSVK.G 2 2.722 0.129 O chain variable region, isolate case5- PTGC1-5. Homo sapiens partial VH4-34 gene for GP:AJ406658_1 rearranged immunoglobulin heavy E.IDHSGSTDYNPSLK.R 2 2.979 0.188 G chain variable region, isolate case4- Supplementary Table 1 98 PTGC2-205. Homo sapiens partial VH3-21 gene for rearranged immunoglobulin heavy GP:AJ406683_1 -.EXQLVESGGGLVKPGGSLR.L 2 3.632 1.000 G, O, P chain variable region, isolate case2- Ki67+-9. Homo sapiens partial VH3-49 gene for rearranged immunoglobulin heavy GP:AJ406724_1 -.EVQLVESGGGLVKPGR.S 1 2.889 0.270 G, O, P chain variable region, isolate case1- Ki67+-333. 2 5.030 0.377 Homo sapiens partial VK L2 gene for rearranged immunoglobulin kappa IPI:IPI00022862.1 GP:AJ406827_1 R.ILIYGASTR.A 2 3.277 0.299 O chain variable region, isolate case1- (93%) Ki67--496. Homo sapiens partial VL 1c gene for rearranged immunoglobulin lambda GP:AJ406861_1 G.GSSNIGSNTVNWYQQLPGTA.P 2 3.061 0.099 G light chain variable region, isolate case4-PTGC2-142. Homo sapiens partial mRNA for immunoglobulin lambda light chain GP:AJ408286_1 variable region (DPL16 gene (locus D.HVVFGGGTR.L 1 1.831 0.143 G 3l)), clone M1u-10 (m1loe10), Kawasaki disease patient. Homo sapiens partial mRNA for immunoglobulin lambda light chain GP:AJ408287_1 variable region (3r.9C5 gene (locus K.YAYWYQQQ.S 1 2.459 0.150 G 3r)), clone M2u-01 (m2loe01), Kawasaki disease patient. Homo sapiens partial mRNA for immunoglobulin lambda light chain GP:AJ408289_1 variable region (1c.10.2/DPL2 gene N.GLWVFGGGTK.L 1 2.026 0.094 G (locus 1c)), clone M2u-05 (m2loe05), Kawasaki disease patient. Homo sapiens partial IGKV gene for IPI:IPI00178276.1 GP:AJ408403_1 immunoglobulin kappa chain variable S.YPPDTFGQGTK.L 2 2.538 0.147 G (92%) region, clone 8. Homo sapiens partial IGKV gene for IPI:IPI00003457.1 GP:AJ408407_1 immunoglobulin kappa chain variable S.YSPYTFGQGTK.L 1 1.980 0.295 G (97%) region, clone 12. Homo sapiens partial IGKV gene for IPI:IPI00161229.1 GP:AJ408421_1 immunoglobulin kappa chain variable N.SYSITFGQGTR.L 1 2.252 0.282 G (91%) region, clone 26. Homo sapiens partial IGKV gene for GP:AJ408422_1 immunoglobulin kappa chain variable R.FSGSGSGTEFTLTIRS.L 2 2.575 0.157 G region, clone 27. Homo sapiens partial IGLV gene for GP:AJ408453_1 immunoglobulin lambda chain variable K.LMIYDVSNRPSGVSDR.F 2 2.699 0.245 G region, clone 58. Homo sapiens partial IGLV gene for GP:AJ408454_1 immunoglobulin lambda chain variable R.VSWYQQPPGTAPQ.L 1 1.945 0.180 G, O, P region, clone 59. 2 3.936 0.387 Homo sapiens partial IGLV gene for GP:AJ408461_1 immunoglobulin lambda chain variable K.LMIYEVGKRPSGVSNR.F 2 3.379 0.301 G, O region, clone 66. Homo sapiens partial IGLV gene for IPI:IPI00017248.1 GP:AJ408486_1 immunoglobulin lambda chain variable R.DSSGNHLVFGGGTQ.L 2 4.102 0.289 G (97%) region, clone 91. Homo sapiens partial IGKV gene for IPI:IPI00003457.1 GP:AJ408511_1 immunoglobulin kappa chain variable R.ASQSIGSWLAWYQQKPGK.A 2 2.840 0.162 G (97%) region, clone 116. Homo sapiens partial IGKV gene for IPI:IPI00053682.1 GP:AJ408517_1 immunoglobulin kappa chain variable S.APYTFGQGTK.L 1 1.984 0.249 G (93%) region, clone 122. Homo sapiens partial IGKV gene for IPI:IPI00024136.1 GP:AJ408553_1 immunoglobulin kappa chain variable R.SNWPYTFGQGTK.L 2 2.984 0.170 G (95%) region, clone 158. Homo sapiens partial IGKV gene for IPI:IPI00003457.1 GP:AJ408556_1 immunoglobulin kappa chain variable A.WYQQTPGKAPR.L 2 2.875 0.332 G (94%) region, clone 161. Homo sapiens partial IGLV gene for GP:AJ408578_1 immunoglobulin lambda chain variable -.QAVLTQPPSASGTPGQR.V 1 2.743 0.360 G, O, P region, clone 183. 2 3.255 0.265 K.LLIYTNNQR.P 2 2.510 0.108 GP:AJ408591_1 Homo sapiens partial IGLV gene for Q.QKPGQAPVLVIYKDNK.R 2 2.623 0.199 G IPI:IPI00178482.1 Supplementary Table 1 99 immunoglobulin lambda chain variable (92%) region, clone 196. Homo sapiens partial IGVK gene for immunoglobulin kappa light chain GP:AJ409172_1 -.EIVLTQSPGTLSLSPGEK.V 1 2.124 0.262 G, O, P variable region, isolate case 1, Hodgkin's disease, VkA27. 2 4.495 0.501 V.KTLAWYQQKPGQ.P 2 3.561 0.226 Homo sapiens partial IGVK gene for immunoglobulin kappa light chain GP:AJ409193_1 R.FSGSGSGTDFTX.T 2 2.861 0.185 G, O, P variable region, isolate case 1, follicular lymphoma, VkA27, cell MB4. R.FSGSGSGTDFTXTISR.L 1 2.536 0.274 2 4.964 0.354 Homo sapiens partial VK-Vd gene for immunoglobulin kappa chain variable GP:AJ410891_1 I.SSYLAWYQQKPGKVPK.L 2 2.978 0.323 G region, from follicular lymphoma: FL6- k. S.SYLAWYQQKPGKVPK.L 2 2.352 0.154 Homo sapiens partial VK-O8-18 gene for immunoglobulin kappa chain GP:AJ410893_1 Q.ASQDISNYLAWYQQK.P 2 2.721 0.099 G variable region, from follicular lymphoma: FL8-k. Homo sapiens partial VK-O8-18 gene for immunoglobulin kappa chain GP:AJ410895_1 K.LLIYDASNLQTGVPSR.F 2 3.372 0.327 O variable region, from follicular lymphoma: FL10-k. Homo sapiens partial VH-f1-p1 gene for immunoglobulin heavy chain GP:AJ410902_1 S.NNGGSTYYADSVK.G 2 2.545 0.163 G variable region, from follicular lymphoma: FL-1H. Homo sapiens partial mRNA for immunoglobulin kappa chain variable GP:AJ410907_1 A.AALESGVPSR.F 1 2.076 0.116 O region, (V1-Vk gene), from multiple myeloma: MM-8k. Homo sapiens partial mRNA for immunoglobulin lambda chain variable GP:AJ410921_1 K.LLIYGDNKR.P 2 2.869 0.159 G region, (VLAMBDA-DPL4 gene), from multiple myeloma: MM-13lambda. Q.PPSVSAAPGEK.V 1 2.555 0.254 Homo sapiens partial mRNA for GP:AJ413992_1 immunoglobulin heavy chain variable A.NNSLYLQINTLRAEYTAVYDSA.R 2 2.474 0.105 G, P region (IGVH gene), isolate CLL006. R.QAPGKGLEWVVN.L 2 2.584 0.163 Homo sapiens partial mRNA for GP:AJ414012_1 immunoglobulin heavy chain variable R.AEDTAVYYCAHPIN.N 2 3.748 0.083 G region (IGVH gene), isolate CLL026. Homo sapiens partial mRNA for IPI:IPI00009792.1 GP:AJ414014_1 immunoglobulin heavy chain variable R.SDDTAVYYCAKLYS.G 2 3.040 0.082 G (96%) region (IGVH gene), isolate CLL028. Homo sapiens partial mRNA for GP:AJ414028_1 immunoglobulin heavy chain variable -.EVHLVDSGGGLINPGGSLR.L 2 3.734 0.415 G region (IGVH gene), isolate CLL042. Homo sapiens mRNA for GP:AJ414564_1 R.PFGERGGLQVPDFSAGYI.I 2 3.225 0.239 O connexin40.1 (CX40.1 gene). Homo sapiens partial IGVKL2 gene for GP:AJ414829_1 immunoglobulin kappa chain variable R.ASQSVSSNLAWXQQK.P 1 2.611 0.159 G region, donor TG, cell73.1. 2 4.062 0.326 Homo sapiens partial IGVKA30 gene GP:AJ414847_1 for immunoglobulin kappa chain K.RLXYAASSLQSGVPSR.F 2 3.387 0.373 P variable region, donor MF, cell29. Homo sapiens partial IGVH3-74 gene GP:AJ415018_1 for immunoglobulin heavy chain S.VTKYADSVK.G 1 2.389 0.234 G variable region, donor MF, cell13. Homo sapiens partial IGVHLSG12.1 GP:AJ415031_1 gene for immunoglobulin heavy chain K.SIAYLQMNSLE.T 2 3.250 0.197 G variable region, donor MF, cell35. Homo sapiens partial IGVH1-69 gene GP:AJ415035_1 for immunoglobulin heavy chain P.GQGLEWMGGIIPLFGSANYAEK.F 2 3.146 0.271 G variable region, donor BJ, cell9. Homo sapiens partial IGVH2-5 gene GP:AJ415042_1 for immunoglobulin heavy chain L.TITKDTSKNQVVLTLTNMDPVDTA.T 2 4.030 0.199 G variable region, donor BJ, cell67. GP:AJ415081_1 Homo sapiens partial IGVLIGLV3S2 K.PGQAPVLVVSDDSDR.P 2 3.515 0.302 G Supplementary Table 1 100 gene for immunoglobulin lambda chain variable region, donor BJ, cell9. Homo sapiens partial IGVL3h gene for GP:AJ415083_1 immunoglobulin lambda chain variable F.DNVRPSGIPER.F 2 2.890 0.272 G region, donor BJ, cell64. Homo sapiens partial IGVL2a2 gene GP:AJ415086_1 for immunoglobulin lambda chain K.LIIYDVSDRPSGVSSR.F 2 2.556 0.137 G variable region, donor BJ, cell38. Homo sapiens partial IGVL2b2 gene GP:AJ415092_1 for immunoglobulin lambda chain L.VSWYQKHPGK.A 2 3.387 0.323 O variable region, donor BJ, cell49. Homo sapiens partial IGVL3r gene for GP:AJ415095_1 immunoglobulin lambda chain variable R.FSGSNSGNTATLIISGT.Q 2 2.867 0.295 P region, donor BJ, cell54. Homo sapiens partial IGVL7b gene for GP:AJ415101_1 immunoglobulin lambda chain variable R.FSGSLLGDK.G 1 1.958 0.107 G region, donor BJ, cell102. Homo sapiens partial IGVL3f gene for GP:AJ415147_1 immunoglobulin lambda chain variable R.FSGSTSGNTTALTISR.V 2 3.514 0.335 O region, donor MF, cell14. Homo sapiens partial IGVL1c gene for GP:AJ415151_1 immunoglobulin lambda chain variable K.LLIYANTQRPSGVPDR.F 2 2.520 0.150 G region, donor MF, cell26. Homo sapiens partial IGVL2a2 gene GP:AJ415156_1 for immunoglobulin lambda chain K.LMIYEVTTRPSGVSNR.F 2 2.871 0.185 G, O, P variable region, donor MF, cell33. L.MIYEVTTRPSGVSNR.F 2 2.328 0.106 Homo sapiens partial IGVH3-30.4 GP:AJ415285_1 gene for immunoglobulin heavy chain L.ISNDGTYKSYAQ.S 1 2.104 0.094 A variable region, donor TG, cell7. Homo sapiens partial IGVH3-30 gene GP:AJ415323_1 for immunoglobulin heavy chain R.GHCEGSDCR.R 1 1.955 0.209 A variable region, donor BJ, cell100. Homo sapiens partial IGVH3-09 gene GP:AJ415325_1 for immunoglobulin heavy chain K.QSLYLEMNNLR.F 2 3.521 0.177 G variable region, donor TG, cell62. Homo sapiens partial IGVH3-23 gene GP:AJ415349_1 for immunoglobulin heavy chain R.VEDTAVYYCASHVRVPGIT.L 2 2.534 0.159 G variable region, donor MF, cell85. Homo sapiens partial IGVKA19/3 IPI:IPI00178045.1 GP:AJ415704_1 gene for immunoglobulin kappa chain K.PGKSPQLLIYLGSNR.A 2 2.581 0.317 G (97%) variable region, donor BJ, cell73. Homo sapiens partial IGVLHumlv GP:AJ415818_1 1042 gene for immunoglobulin lambda D.KTDRPSGVPDR.F 2 2.577 0.082 P chain variable region, donor TG, cell6. D.RPSGVPDRFSGSQ.S 2 3.093 0.138 Homo sapiens partial IGVL2c gene for GP:AJ415840_1 immunoglobulin lambda chain variable R.FSASKSF.N 1 1.937 0.155 G region, donor BJ, cell101. Homo sapiens partial IGVL3h gene for IPI:IPI00166489.1 GP:AJ415844_1 immunoglobulin lambda chain variable R.FSGSNSGSTATLTISR.S 2 3.874 0.478 G, O (91%) region, donor TG, cell96. Homo sapiens partial IGVL3h gene for GP:AJ415850_1 immunoglobulin lambda chain variable R.PGQAPVLVVYDDR.D 2 4.630 0.443 G, O region, donor TG, cell109. Homo sapiens partial IGVL3h gene for GP:AJ415867_1 immunoglobulin lambda chain variable R.ISGSKSGTTATLTISR.V 2 2.941 0.277 G region, donor MF, cell72. Homo sapiens partial IGVL1e gene for GP:AJ415873_1 immunoglobulin lambda chain variable G.NDNRPSGVPDR.F 2 2.855 1.000 G, P region, donor MF, cell93. Homo sapiens mRNA for putative GP:AJ416091_1 L.YSLQPPTDKDNGDSRLASAIVDT.V 2 3.598 0.119 O, P emu2 protein. Homo sapiens mRNA for H-rev107- IPI:IPI00064671.1 GP:AJ416558_1 A.KQPPPGTLEQGRSIQQGEKAVVSL.E 2 2.973 0.130 O, P like protein 5 (HRLP5 gene). (95%) Homo sapiens partial mRNA for GP:AJ416559_1 immunoglobulin heavy chain variable -.EVQVVESGGGLVQPGR.S 2 4.189 0.251 O region (IGVH gene), isolate CLL043. Homo sapiens mRNA for glutamate IPI:IPI00064667.1 GP:AJ417564_1 carboxypeptidase-like protein 2 K.EWVAIESDSVQPVPR.F 2 4.897 0.456 O, P (97%) (CPGL2 gene). K.SVVLIPLGAVDDGEHSQNEK.I 2 3.739 0.420 R.ALEQDLPVNIK.F 2 3.530 0.275 R.MMAVAADTLQR.L 2 3.756 0.321 Homo sapiens partial IGVH3-23 gene GP:AJ421274_1 -.EVHLLESGGGLVKPGGSLR.I 2 5.167 0.520 G for immunoglobulin heavy chain Supplementary Table 1 101 variable region, isolate case 1, f3-38. Homo sapiens mRNA for FLJ00004 protein, partial cds; For this clone, GeneMark analysis triggered an alert IPI:IPI00186549.1 GP:AK000004_1 L.RMESGRGSSTPP.G 2 2.902 0.157 O for spurious CDS split. The result of (98%) GeneMark analysis of the nucleotide sequence of this clone i. Homo sapiens cDNA FLJ20035 fis, IPI:IPI00217606.1 GP:AK000042_1 clone COL00213; unnamed protein L.VKEGYLDQEG.N 2 2.831 0.180 P (95%) product. Homo sapiens cDNA FLJ20069 fis, IPI:IPI00170917.1 GP:AK000076_1 clone COL01816; unnamed protein I.YDLSWSK.D 1 1.941 0.177 O (98%) product. Homo sapiens cDNA FLJ20073 fis, IPI:IPI00217018.1 GP:AK000080_1 clone COL02320; unnamed protein F.IEALHKDEGNEAV.E 2 3.331 0.173 G (97%) product. I.EALHKDEGNEAV.E 1 2.739 0.113 2 3.357 0.125 L.NFILANIILSCIQPTSR.L 2 2.398 0.122 Homo sapiens cDNA FLJ20105 fis, IPI:IPI00184374.1 GP:AK000112_1 clone COL04811; unnamed protein Q.FDASTPKNDISPPGR.F 2 2.815 0.218 P (91%) product. Homo sapiens cDNA FLJ20132 fis, GP:AK000139_1 clone COL06441; unnamed protein E.AGFMTREERKK.F 1 1.952 0.152 A, G product. F.QGSTFDITLAKEDMQFQ.R 1 2.351 0.102 Homo sapiens cDNA FLJ20199 fis, GP:AK000206_1 clone COLF1162; unnamed protein I.IQNGGHLDAK.A 2 2.658 0.229 O product. Homo sapiens cDNA FLJ20206 fis, IPI:IPI00106907.1 GP:AK000213_1 clone COLF1582; unnamed protein R.PTATPCGCVKPALETG.N 2 2.516 0.138 G (99%) product. Homo sapiens cDNA FLJ20357 fis, K.AEGGPFKDGETLEGSDAEESLDKTAES IPI:IPI00015749.2 GP:AK000364_1 clone HEP16545; unnamed protein 3 3.528 0.221 P SLLEDEIAQGEE.L (91%) product. Homo sapiens cDNA FLJ20449 fis, IPI:IPI00178575.1 GP:AK000456_1 clone KAT05575; unnamed protein I.SLLHSSKENLRR.E 1 2.016 0.100 G (99%) product. Homo sapiens cDNA FLJ20476 fis, IPI:IPI00005113.1 GP:AK000483_1 clone KAT07209; unnamed protein A.AQNNTVTVPK.N 2 2.549 0.135 G (98%) product. Homo sapiens cDNA FLJ20489 fis, GP:AK000496_1 clone KAT08285; unnamed protein Y.LRPGQQSQEVK.V 1 2.281 0.111 G, P product. 2 2.787 0.082 Homo sapiens cDNA FLJ20539 fis, GP:AK000546_1 clone KAT11311; unnamed protein R.VPGPAEGPAEPAAE.A 1 1.957 0.188 A product. Homo sapiens cDNA FLJ20548 fis, GP:AK000555_1 clone KAT11542; unnamed protein E.SHADLLRKAETVLDLMVTNS.Q 2 3.511 0.172 G, P product. F.LLGETVGGDK.E 1 2.416 0.123 Homo sapiens cDNA FLJ20581 fis, IPI:IPI00016607.1 GP:AK000588_1 clone REC00491; unnamed protein E.ASTEHNCMRTKSR.D 2 2.343 0.125 A (97%) product. S.ALAEHPAVLESAVVSSPDPIRGEV.V 2 2.421 0.115 Homo sapiens cDNA FLJ20707 fis, IPI:IPI00217013.1 GP:AK000714_1 clone KAIA1223; unnamed protein V.DITQDLVDESEEERFDDMSS.P 2 3.025 0.110 G (96%) product. Homo sapiens cDNA FLJ10034 fis, clone HEMBA1000910, weakly similar GP:AK000896_1 to MELANOMA-ASSOCIATED A.SSTPSEASSTALVQKP.V 2 2.814 0.081 A ANTIGEN B1; unnamed protein product. Q.KPVTRSNFQGTKKSLLMSILALIFIMGN 2 2.525 0.117 SAK.E Homo sapiens cDNA FLJ10051 fis, GP:AK000913_1 clone HEMBA1001281; unnamed R.LVSAKQL.G 1 1.983 0.111 A protein product. Homo sapiens cDNA FLJ10076 fis, clone HEMBA1001847, moderately IPI:IPI00026326.1 GP:AK000938_1 E.ADEKPFICAQCGK.T 1 1.826 0.111 G, O similar to ZINC FINGER PROTEIN 29; (99%) unnamed protein product. H.TGEKPYKCSECGKSFSRSSNR.I 2 2.212 0.169 GP:AK001188_1 Homo sapiens cDNA FLJ10326 fis, A.NKITELY.K 1 2.062 0.100 A IPI:IPI00017283.1 Supplementary Table 1 102 clone NT2RM2000577, weakly similar (98%) to ISOLEUCYL-TRNA SYNTHETASE (EC 6.1.1.5); unnamed protein product. Homo sapiens cDNA FLJ10357 fis, IPI:IPI00018134.1 GP:AK001219_1 clone NT2RM2001221, weakly similar A.LLTGRAPETLDSSGDV.S 1 2.083 0.171 G (96%) to KALIRIN; unnamed protein product. Homo sapiens cDNA FLJ10375 fis, IPI:IPI00220039.1 GP:AK001237_1 clone NT2RM2001950; unnamed L.EDTWYTRFALKYQP.I 1 2.553 0.108 G, O (96%) protein product. Y.PGKSLLRRLLTSGIVIQVFPLHDSEALK 2 2.432 0.158 K.L Homo sapiens cDNA FLJ10377 fis, clone NT2RM2001989, weakly similar E.KGSKACRGFGYVTFSMLEDVQRALKEI GP:AK001239_1 3 3.933 0.228 G, O to NUCLEOLAR PROTEIN NOP4; TTFEGCKI.N unnamed protein product. S.ARSEQLEELFSQV.G 2 2.810 0.108 Homo sapiens cDNA FLJ10408 fis, GP:AK001270_1 clone NT2RM4000585; unnamed R.APVGPRAPPPDEEDPRLKCKNC.E 2 2.555 0.116 P protein product. Homo sapiens cDNA FLJ10450 fis, clone NT2RP1000954, weakly similar IPI:IPI00018194.5 GP:AK001312_1 K.THLAQLQNTEEF.L 2 2.495 0.159 O, P to RING CANAL PROTEIN; unnamed (99%) protein product. T.TQLEVAVSGAAGANL.N 1 2.243 0.141 Homo sapiens cDNA FLJ10470 fis, clone NT2RP2000032, weakly similar IPI:IPI00018213.1 GP:AK001332_1 L.QELDLKSNNIRT.I 1 2.425 0.112 A, O, P to RAS SUPPRESSOR PROTEIN 1; (98%) unnamed protein product. 2 3.136 0.084 N.LQELDLKSNNIRTIEEIIS.F 2 3.186 0.100 Homo sapiens cDNA FLJ10499 fis, clone NT2RP2000346, weakly similar GP:AK001361_1 to MYELOID DIFFERENTIATION L.PSSSVPSSPVQTTPLSQAVATPSRS.S 2 2.991 0.089 A, G PRIMARY RESPONSE PROTEIN MYD116; unnamed protein product. R.SSAAAAAAL.D 1 1.895 0.100 Homo sapiens cDNA FLJ10572 fis, clone NT2RP2003125, weakly similar IPI:IPI00018726.1 GP:AK001434_1 K.DVTVYNPELDKWHNL.E 1 2.570 0.091 A to RING CANAL PROTEIN; unnamed (96%) protein product. Homo sapiens cDNA FLJ10600 fis, IPI:IPI00171453.1 GP:AK001462_1 clone NT2RP2004999; unnamed L.QPQASLHLKEK.V 2 2.863 0.120 G (97%) protein product. Homo sapiens cDNA FLJ10624 fis, clone NT2RP2005525, highly similar GP:AK001486_1 E.IPELKK.T 1 2.260 1.000 G to Mus musculus kanadaptin mRNA; unnamed protein product. Homo sapiens cDNA FLJ10706 fis, IPI:IPI00155637.1 GP:AK001568_1 clone NT2RP3000852; unnamed K.DIITSLCEDI.L 1 1.921 0.106 O (97%) protein product. Homo sapiens cDNA FLJ10847 fis, GP:AK001709_1 clone NT2RP4001379; unnamed A.NYLFLHQLHLGVIGSA.L 1 2.143 0.171 A, G protein product. V.YELAIIVY.M 1 2.251 0.096 Homo sapiens cDNA FLJ10852 fis, clone NT2RP4001498, weakly similar IPI:IPI00216752.1 GP:AK001714_1 to ANKYRIN REPEAT-CONTAINING A.YLISKGQSVNMTDVNGQTPL.M 2 2.563 0.119 A, P (97%) PROTEIN AKR1; unnamed protein product. H.LAVLFQHMPIIAYLISK.G 2 2.771 0.113 Homo sapiens cDNA FLJ10853 fis, GP:AK001715_1 clone NT2RP4001502; unnamed Y.SSLMKVENMSS.N 1 2.378 0.084 P protein product. Homo sapiens cDNA FLJ10904 fis, clone OVARC1000013, weakly similar IPI:IPI00221220.1 GP:AK001766_1 to APOPTOTIC PROTEASE L.SGGNDLCVWNRKLDLLCKTS.H 2 2.981 0.259 A, G, O, P (99%) ACTIVATING FACTOR 1; unnamed protein product. Homo sapiens cDNA FLJ11186 fis, GP:AK002048_1 clone PLACE1007524; unnamed D.ISAIKPNKDGLKNKANY.E 1 2.387 0.127 G protein product. Homo sapiens cDNA FLJ11219 fis, IPI:IPI00184302.1 GP:AK002081_1 clone PLACE1008122; unnamed I.KNDKTEKEIYTLAK.E 1 2.410 0.105 G (97%) protein product.
Supplementary Table 1 103 Homo sapiens cDNA FLJ11251 fis, IPI:IPI00010953.2 GP:AK002113_1 clone PLACE1008813; unnamed Q.YNETLLK.K 1 2.096 0.091 A (95%) protein product. Homo sapiens cDNA FLJ11301 fis, clone PLACE1009908, weakly similar to HYPOTHETICAL GTP-BINDING IPI:IPI00106296.1 GP:AK002163_1 S.ELNDGYDWGRLNLQSV.T 2 2.547 0.171 G, O PROTEIN IN SEH1-PRP20 (94%) INTERGENIC REGION; unnamed protein product. S.TASSENGAGKPWKK.H 2 2.929 0.083 Homo sapiens cDNA FLJ11712 fis, IPI:IPI00002267.1 GP:AK021774_1 clone HEMBA1005185; unnamed E.PSASLPNPPSKKIK.L 2 2.507 0.139 O (95%) protein product. Homo sapiens cDNA FLJ12118 fis, clone MAMMA1000085, weakly IPI:IPI00101811.1 GP:AK022180_1 similar to PUTATIVE CYSTEINYL- S.FLEDAR.A 1 1.960 0.095 G, P (91%) TRNA SYNTHETASE C29E6.06C (EC 6.1.1.16); unnamed protein product. S.LKNYITIK.D 1 2.241 0.093 Homo sapiens cDNA FLJ12345 fis, GP:AK022407_1 clone MAMMA1002294; unnamed G.CLGAAGPTSSGRAAR.T 2 2.674 0.190 A protein product. Homo sapiens cDNA FLJ12439 fis, R.MYKLGDGVDKDEAKAEVLKNRAQQLH IPI:IPI00011992.2 GP:AK022501_1 clone NT2RM1000127; unnamed 3 3.625 0.119 A RE.Q (99%) protein product. Homo sapiens cDNA FLJ12538 fis, clone NT2RM4000356, moderately IPI:IPI00033893.1 GP:AK022600_1 F.QEGKEFADSQKLLFM.E 2 2.704 0.131 O similar to RAS-RELATED PROTEIN (92%) RAB-17; unnamed protein product. Homo sapiens cDNA FLJ12642 fis, IPI:IPI00030384.1 GP:AK022704_1 clone NT2RM4001965; unnamed V.DNLTLMVEHTDIPEASPASTPQI.I 2 2.607 0.121 G, O (99%) protein product. Homo sapiens cDNA FLJ12660 fis, clone NT2RM4002174, moderately IPI:IPI00185504.1 GP:AK022722_1 A.SGKGGVGKSTTAVNL.A 2 2.852 0.165 A, O similar to MRP PROTEIN; unnamed (92%) protein product. S.QNIPITGAVIVSTPQDIALMDAHKGAEM 2 2.492 0.134 FRR.V Homo sapiens cDNA FLJ12768 fis, clone NT2RP2001576, weakly similar to HYPOTHETICAL 62.2 KD GP:AK022830_1 S.LLSSPRSYLLL.L 1 2.200 0.152 G PROTEIN C4G8.12C IN CHROMOSOME I; unnamed protein product. Homo sapiens cDNA FLJ12783 fis, clone NT2RP2001876, moderately IPI:IPI00034205.1 GP:AK022845_1 similar to ALLOGRAFT N.RFQGGKAFGL.L 1 2.078 0.191 P (99%) INFLAMMATORY FACTOR-1; unnamed protein product. Homo sapiens cDNA FLJ12934 fis, clone NT2RP2004978, weakly similar IPI:IPI00185543.1 GP:AK022996_1 D.TLPASIPHVIARRHK.Q 2 2.254 0.111 A, P to ACTIN-LIKE PROTEIN ARP8; (99%) unnamed protein product. L.MKMGFSGIVVHQESVCATYGSGLSST 2 2.578 0.267 CIV.D Homo sapiens cDNA FLJ12960 fis, clone NT2RP2005605, weakly similar IPI:IPI00074010.1 GP:AK023022_1 to QUEUINE TRNA- R.LRLLSSVTAELPE.D 2 2.699 0.095 G, O (99%) RIBOSYLTRANSFERASE (EC 2.4.2.29); unnamed protein product. Homo sapiens cDNA FLJ12994 fis, clone NT2RP3000207, weakly similar IPI:IPI00010250.1 GP:AK023056_1 to GLUCOAMYLASE S1/S2 L.HSQIQESSLN.Q 2 2.816 0.181 G (95%) PRECURSOR (EC 3.2.1.3); unnamed protein product. Homo sapiens cDNA FLJ13220 fis, clone NT2RP4002047, moderately IPI:IPI00161179.1 GP:AK023282_1 A.TGAALLVAPGPRSAPTLGAA.P 1 2.405 0.187 G, P similar to GTP-BINDING PROTEIN (97%) LEPA; unnamed protein product. K.QVLDKLQVERERGITVKAQTASLFYNC 3 3.606 0.173 EGK.Q N.FSIVAHVDHGKSTLTDR.L 2 3.667 0.198 V.KAQTASLFYNCEGKQYLLNLI.D 2 2.477 0.133 Homo sapiens cDNA FLJ13262 fis, A.DGRRHHGGGGSRPAPRRKSPLPAAA GP:AK023324_1 clone OVARC1000912; unnamed 3 3.530 0.155 G RAPSPARPR.R protein product.
Supplementary Table 1 104 P.HACRDGGGGAGKPGAPRGGLGR.G 2 2.482 0.129 Homo sapiens cDNA FLJ13397 fis, IPI:IPI00165121.1 GP:AK023459_1 clone PLACE1001351; unnamed E.IEDASEPLIDPVYGHGSQSL.I 2 2.411 0.149 P (96%) protein product. L.INLLLTGHAVSNVWDGDR.E 2 2.216 0.105 Homo sapiens cDNA FLJ13646 fis, GP:AK023708_1 clone PLACE1011325; unnamed R.DIAILK.E 1 1.812 1.000 P protein product. Homo sapiens cDNA FLJ13664 fis, GP:AK023726_1 clone PLACE1011649; unnamed K.KLYDCLE.E 1 1.806 0.080 P protein product. Homo sapiens cDNA FLJ13704 fis, clone PLACE2000274, weakly similar IPI:IPI00178742.1 GP:AK023766_1 E.ERPDLEEAKNQLI.I 1 2.387 0.086 O to DYNEIN BETA CHAIN, CILIARY; (99%) unnamed protein product. Homo sapiens cDNA FLJ13739 fis, IPI:IPI00185877.1 GP:AK023801_1 clone PLACE3000197; unnamed P.NDPVPIPDK.R 1 2.819 0.102 P (91%) protein product. Homo sapiens cDNA FLJ13755 fis, IPI:IPI00015256.2 GP:AK023817_1 clone PLACE3000363; unnamed P.CSLSVQLDFTDPLLAKERVLSNL.R 2 3.128 0.173 G, P (99%) protein product. R.ILLLVQSRQNL.V 1 2.157 0.125 Homo sapiens cDNA FLJ13798 fis, C.DMGLLMGAAILGDILLKVAAILQTHLPG IPI:IPI00166502.1 GP:AK023860_1 clone THYRO1000124; unnamed 3 4.364 0.110 G KR.P (99%) protein product. Homo sapiens cDNA FLJ13841 fis, IPI:IPI00003009.1 GP:AK023903_1 clone THYRO1000787; unnamed C.RQDTPTLSSMESQEAQCDL.R 2 2.943 0.126 A, G (91%) protein product. E.FESPIPEAKDSSK.A 2 2.701 0.113 Homo sapiens cDNA FLJ13853 fis, clone THYRO1000951, weakly similar IPI:IPI00179845.1 GP:AK023915_1 to DIHYDROXYACETONE KINASE 2 D.RAAGDGDCGTTHSR.A 2 2.441 0.290 G, O (91%) (EC 2.7.1.29); unnamed protein product. E.GIPVEMVVIGDDSAFTVLK.K 1 1.884 0.193 Homo sapiens cDNA FLJ13881 fis, clone THYRO1001458, moderately L.EKGNLRVKQLKRQLEEAEEEASRAQA GP:AK023943_1 similar to MYOSIN HEAVY CHAIN, 3 4.068 0.118 A, G GRR.R NONMUSCLE TYPE B; unnamed protein product. R.AEKRLKEVVLQVEEE.R 2 2.759 0.263 Homo sapiens cDNA FLJ13976 fis, clone Y79AA1001594, weakly similar IPI:IPI00009702.1 GP:AK024038_1 to HYALURONAN-MEDIATED H.PETQLDLQKPDVIK.R 1 2.157 0.107 O (96%) MOTILITY RECEPTOR; unnamed protein product. Homo sapiens cDNA FLJ13984 fis, F.AFVHDVCDDGLPYPFPDGILDVILLVFV GP:AK024046_1 clone Y79AA1001846; unnamed 3 3.826 0.117 P LSSIHPDR.T protein product. Homo sapiens cDNA FLJ14006 fis, clone Y79AA1002399, highly similar to IPI:IPI00218097.1 GP:AK024068_1 T.EASLASRR.E 1 1.964 0.118 O Homo sapiens mRNA for sperm (91%) protein; unnamed protein product. Homo sapiens cDNA FLJ14129 fis, clone MAMMA1002617, weakly GP:AK024191_1 E.KPHQCGHCGRAFR.A 1 1.881 0.177 G similar to ZINC FINGER PROTEIN 135; unnamed protein product. Homo sapiens cDNA FLJ14202 fis, G.FPAVTSKPACPVCWGWLSFGLPITGR. GP:AK024264_1 clone NT2RP3002985; unnamed 3 3.520 0.127 O L protein product. Homo sapiens mRNA for FLJ00018 GP:AK024429_1 protein, partial cds; Start codon is not I.PSVPNTPSLSSTPTLSCDSWL.Q 2 2.751 0.096 O identified.. P.EVHAPESGLRTSLGTASGSRRS.R 2 3.201 0.239 Homo sapiens mRNA for FLJ00020 GP:AK024431_1 protein, partial cds; Start codon is not S.GNSEVEDRPQDPLARLR.H 1 1.891 0.153 A identified.. Homo sapiens mRNA for FLJ00022 protein, partial cds; For this clone, GeneMark analysis triggered an alert GP:AK024432_1 R.NHDSSQPTTPSQSSAASTPAPNLPR.H 2 3.561 0.099 G for spurious CDS split. The result of GeneMark analysis of the nucleotide sequence of this clone i. Homo sapiens mRNA for FLJ00043 GP:AK024451_1 protein, partial cds; Start codon is not L.PEAQVASGAGAGAPRASSPEK.A 1 1.897 0.157 A, G identified.. Supplementary Table 1 105 L.VAQEIEVGL.L 1 2.009 0.084 Homo sapiens mRNA for FLJ00044 GP:AK024452_1 protein, partial cds; Start codon is not I.REPGSPGEPERL.Y 2 2.790 0.187 O identified.. Homo sapiens mRNA for FLJ00045 protein, partial cds; For this clone, GeneMark analysis triggered an alert IPI:IPI00165245.1 GP:AK024453_1 E.YDALQITFTALEGKLR.K 2 2.509 0.216 P for spurious CDS split. The result of (92%) GeneMark analysis of the nucleotide sequence of this clone i. Homo sapiens mRNA for FLJ00083 GP:AK024484_1 protein, partial cds; Start codon is not L.SVLQHSEALGLQQGEGEPPQAWAP.M 2 3.090 0.156 G identified.. Homo sapiens mRNA for FLJ00087 protein, partial cds; For this clone, GeneMark analysis triggered an alert IPI:IPI00166482.1 GP:AK024488_1 E.RWFPLLGAPAGAALRAR.I 2 2.561 0.185 A, P for spurious CDS split. The result of (92%) GeneMark analysis of the nucleotide sequence of this clone i. R.ATGRAQALVTDLGTA.E 2 2.498 0.151 Homo sapiens cDNA: FLJ20980 fis, GP:AK024633_1 clone ADSU01986; unnamed protein K.QQQEQQQKPVQAK.T 1 1.980 0.160 G product. Homo sapiens cDNA: FLJ21019 fis, IPI:IPI00161009.1 GP:AK024672_1 clone CAE06064; unnamed protein Y.LRNPILRHTSGALYA.P 2 2.887 0.135 A (93%) product. Homo sapiens cDNA: FLJ21054 fis, GP:AK024707_1 clone CAS00538; unnamed protein M.EQLRLSLAEELSTYKAMLL.P 2 3.498 0.123 O product. Homo sapiens cDNA: FLJ21077 fis, GP:AK024730_1 clone CAS02152; unnamed protein P.LLSKSQSIL.I 1 2.130 0.145 G product. Homo sapiens cDNA: FLJ21080 fis, L.KVLDCAMDACINLGLLEEALFYGTRTM IPI:IPI00165073.1 GP:AK024733_1 clone CAS02449; unnamed protein 2 2.606 0.184 A, P EPY.R (97%) product. L.PDINIYQL.K 1 2.095 0.145 Homo sapiens cDNA: FLJ21082 fis, IPI:IPI00010376.1 GP:AK024735_1 clone CAS02992; unnamed protein F.FAGDGSWYRALVKEI.L 2 3.519 0.096 O, P (97%) product. Q.ARVVEVTENGIGV.E 2 2.667 0.093 Homo sapiens cDNA: FLJ21103 fis, IPI:IPI00002240.1 GP:AK024756_1 clone CAS04883; unnamed protein S.DIDEIFGFFNDGEPPTKK.P 2 2.929 0.296 O, P (95%) product. Homo sapiens cDNA: FLJ21126 fis, IPI:IPI00025215.1 GP:AK024779_1 clone CAS06183; unnamed protein D.TQQLVQQSQSV.H 2 2.728 0.111 A, G (95%) product. R.LIPHAKTFSPGDGFPLLQFKSK.Q 2 2.225 0.153 Homo sapiens cDNA: FLJ21319 fis, GP:AK024972_1 clone COL02312; unnamed protein L.PVVEEGEVLSHSLEAEHRLLK.A 2 3.234 0.123 P product. Homo sapiens cDNA: FLJ21347 fis, IPI:IPI00154567.1 GP:AK025000_1 clone COL02724; unnamed protein L.TEAGNISPSQDPKGELQ.G 2 3.068 0.110 P (99%) product. Homo sapiens cDNA: FLJ21511 fis, IPI:IPI00184669.1 GP:AK025164_1 clone COL05748; unnamed protein Q.MSNKVILTLSAIATLDR.I 2 2.778 0.096 P (97%) product. Homo sapiens cDNA: FLJ21558 fis, IPI:IPI00186929.1 GP:AK025211_1 clone COL06372; unnamed protein I.FYELFTICTSIVAEDKKGNC.A 2 2.852 0.132 P (91%) product. Homo sapiens cDNA: FLJ21665 fis, IPI:IPI00015671.1 GP:AK025318_1 clone COL08913; unnamed protein A.FLHWYLREGMEEAEFLEAREDL.A 2 2.584 0.133 A, P (94%) product. L.ERTRKLAEQCGGLQGFLIFR.S 2 2.446 0.195 Homo sapiens cDNA: FLJ21810 fis, GP:AK025463_1 clone HEP01030; unnamed protein S.KAVYSTNCPVWEEAFR.F 1 2.461 0.086 A product. Homo sapiens cDNA: FLJ21824 fis, IPI:IPI00179061.1 GP:AK025477_1 clone HEP01329; unnamed protein A.TATLEGNQIFNNR.F 2 2.753 0.141 A, O, P (99%) product. Homo sapiens cDNA: FLJ21870 fis, GP:AK025523_1 clone HEP02445; unnamed protein A.APESLPGQGRELGEGEPP.A 2 2.731 0.130 G product. Homo sapiens cDNA: FLJ21908 fis, IPI:IPI00002408.1 GP:AK025561_1 clone HEP03830; unnamed protein K.KNSSQDVLFPTS.D 1 2.055 0.131 O (94%) product. GP:AK025598_1 Homo sapiens cDNA: FLJ21945 fis, A.QDVSIFPNVHSDDSQVK.A 1 2.451 0.162 G IPI:IPI00018786.1 Supplementary Table 1 106 clone HEP04702; unnamed protein (98%) product. 2 3.479 0.235 Homo sapiens cDNA: FLJ22184 fis, GP:AK025837_1 clone HRC00983; unnamed protein L.ETQSSLAPPSLQTPPASLTTPPLEN.L 2 3.100 0.122 P product. Homo sapiens cDNA: FLJ22422 fis, GP:AK026075_1 clone HRC08651; unnamed protein L.ADYAFTSYSPSLLA.I 1 2.215 0.112 G, O product. S.RQQLCNLECIVLHK.L 2 2.730 0.085 Homo sapiens cDNA: FLJ22427 fis, IPI:IPI00030450.1 GP:AK026080_1 clone HRC09013; unnamed protein A.DTPMSPLLKGSLSQELSK.S 2 2.726 0.136 P (91%) product. Homo sapiens cDNA: FLJ22439 fis, GP:AK026092_1 clone HRC09236; unnamed protein M.DPALQLGEGSYYLTTTYGALEHI.K 2 2.410 0.108 A, P product. M.EKILQKFTSMHKAYSPEKK.I 3 3.567 0.213 Homo sapiens cDNA: FLJ22757 fis, GP:AK026410_1 clone KAIA0803; unnamed protein Q.RGGSLRAPALPSRSDR.L 2 2.974 0.214 O product. Homo sapiens cDNA: FLJ22764 fis, IPI:IPI00170865.1 GP:AK026417_1 clone KAIA1006; unnamed protein N.KSCQVSTRAGSGQDQCR.K 2 2.544 0.127 A (99%) product. Homo sapiens cDNA: FLJ22969 fis, IPI:IPI00010251.2 GP:AK026622_1 clone KAT10759; unnamed protein L.GVLLLGAARLPR.G 2 2.571 0.119 P (92%) product. Homo sapiens cDNA: FLJ23027 fis, GP:AK026680_1 clone LNG01826; unnamed protein K.TYKTTIEEDKSV.L 2 2.705 0.325 A product. Homo sapiens cDNA: FLJ23121 fis, IPI:IPI00165021.1 GP:AK026774_1 clone LNG07996; unnamed protein V.WKKWQLTKGLRDVAK.S 2 3.013 0.095 G (93%) product. Homo sapiens cDNA: FLJ23142 fis, GP:AK026795_1 clone LNG09115; unnamed protein L.LNKHKGNITFETMMEILR.D 3 3.748 0.254 O product. Homo sapiens cDNA: FLJ23342 fis, GP:AK026995_1 clone HEP13470; unnamed protein G.GIPKSPGLY.A 1 2.368 0.083 O, P product. G.SAAGSGAAASGGLGLGLGGRSAASSS 3 3.685 0.149 VSFSPGGGGGGAAAAAAAACR.G P.KSIYIKF.V 1 2.165 0.113 Homo sapiens cDNA: FLJ23403 fis, GP:AK027056_1 clone HEP18857; unnamed protein L.SLGAKSEIATDKLSFPLK.N 1 1.960 0.160 O product. Homo sapiens cDNA: FLJ23445 fis, GP:AK027098_1 clone HSI01721; unnamed protein I.RKRLLIDGDGAGGDRRINLLVKSFI.K 2 2.735 0.142 A, G, P product. Homo sapiens cDNA: FLJ23451 fis, IPI:IPI00015555.1 GP:AK027104_1 clone HSI06456; unnamed protein A.DVKEVLLTDGNEK.A 2 2.805 0.156 O, P (91%) product. Homo sapiens cDNA: FLJ23510 fis, GP:AK027163_1 clone LNG03216; unnamed protein R.GTSQVTGQEQGR.A 2 3.148 0.219 P product. Homo sapiens cDNA: FLJ23529 fis, IPI:IPI00187146.1 GP:AK027182_1 clone LNG06042; unnamed protein A.YPSLKPLGSWVR.D 2 2.975 0.126 G (99%) product. Homo sapiens cDNA FLJ14399 fis, GP:AK027305_1 clone HEMBA1003711; unnamed F.ALVRANPPANVTWIDQDGPVTVNTS.D 2 2.616 0.182 P protein product. Homo sapiens cDNA FLJ14400 fis, clone HEMBA1003742, weakly similar IPI:IPI00151358.1 GP:AK027306_1 to Homo sapiens cleft lip and palate A.FKNDISFWKKK.K 2 2.939 0.135 A, O, P (95%) transmembrane protein 1 (CLPTM1) mRNA; unnamed protein product. Y.DTQAMKYLSYLLYPLCVGGAVYSLL.N 2 2.773 0.099 Homo sapiens cDNA FLJ14404 fis, IPI:IPI00010445.1 GP:AK027310_1 clone HEMBA1004055; unnamed V.PKNDTDDESETPEELEEEIPVV.I 2 2.929 0.115 A (92%) protein product. Homo sapiens cDNA FLJ14464 fis, IPI:IPI00167358.1 GP:AK027370_1 clone MAMMA1000309; unnamed A.SLSVQDRYSPPNADGHKAVF.V 2 2.426 0.135 G, P (97%) protein product. S.AGPVETSKGLPGQEGL.V 1 2.372 0.176 Homo sapiens cDNA FLJ14473 fis, clone MAMMA1001080, highly similar IPI:IPI00178429.1 GP:AK027379_1 G.FSPWGQGTLVTVSSASPTSPK.V 2 3.280 0.429 P to Homo sapiens SNC73 protein (92%) (SNC73) mRNA; unnamed protein Supplementary Table 1 107 product. S.PWGQGTLVTVSSASPTSPK.V 2 3.538 0.434 Homo sapiens cDNA FLJ14558 fis, clone NT2RM2001997, weakly similar IPI:IPI00074799.1 GP:AK027464_1 to PROTEIN DISULFIDE F.FPCNRKDLSVK.Y 2 3.035 0.099 G (97%) ISOMERASE PRECURSOR (EC 5.3.4.1); unnamed protein product. Homo sapiens cDNA FLJ14636 fis, clone NT2RP2001233, weakly similar GP:AK027542_1 C.GKSFSYSATHRIHER.T 1 2.086 0.121 P to ZINC FINGER PROTEIN 91; unnamed protein product. Homo sapiens cDNA FLJ14642 fis, clone NT2RP2001560, weakly similar F.AANSERSQTTLQEQLKKNKGFRRFVR. IPI:IPI00180062.1 GP:AK027548_1 3 3.606 0.143 O, P to VAV2 PROTEIN; unnamed protein L (91%) product. L.QLQDLLPLPLQ.R 1 2.223 0.165 2 2.631 0.084 Homo sapiens cDNA FLJ14710 fis, clone NT2RP3000632, weakly similar IPI:IPI00102073.1 GP:AK027616_1 A.YPCEECGKSFSQ.K 2 2.411 0.120 A, O to ZINC FINGER PROTEIN 84; (98%) unnamed protein product. Y.LHQHQKQ.H 2 2.402 0.149 Homo sapiens cDNA FLJ14744 fis, GP:AK027650_1 clone NT2RP3002770; unnamed R.ELGSSPSGPLNIQRIDDFSVV.S 2 2.980 0.109 G protein product. Homo sapiens cDNA FLJ14854 fis, K.EPEKQQLYDIPASPKKAGLHPPDSQAS IPI:IPI00160340.2 GP:AK027760_1 clone PLACE1000972; unnamed 3 3.844 0.177 P NPGP.L (99%) protein product. Homo sapiens cDNA FLJ14919 fis, clone PLACE1007243, weakly similar S.VFNLSNAIMGSGILGLAFALANTGILLFL IPI:IPI00184230.1 GP:AK027825_1 3 3.939 0.186 G to UNC-47 PROTEIN; unnamed VPLTSV.T (96%) protein product. Homo sapiens cDNA FLJ14927 fis, clone PLACE1009094, weakly similar GP:AK027833_1 to FURIN-LIKE PROTEASE 2 E.ETGEFVSSNASEVKR.I 2 2.671 0.215 G PRECURSOR (EC 3.4.21.75); unnamed protein product. Homo sapiens cDNA FLJ30081 fis, clone BGGI12000693, weakly similar GP:AK054643_1 to POLYHOMEOTIC-PROXIMAL F.YVASFPVALPLQP.P 2 3.003 0.133 A CHROMATIN PROTEIN; unnamed protein product. S.ARRAPRKGGPGPASARPSESKEMTGA 2 2.996 0.164 R.L Homo sapiens cDNA FLJ30131 fis, GP:AK054693_1 clone BRACE1000159; unnamed S.EAQEGLQKFKVVRA.G 1 2.844 0.190 A protein product. Homo sapiens cDNA FLJ30134 fis, clone BRACE1000187, weakly similar IPI:IPI00043863.1 GP:AK054696_1 to MICROTUBULE-ASSOCIATED K.QTASLTAAYGQLSKGK.P 2 3.033 0.082 A (96%) PROTEIN 4; unnamed protein product. Homo sapiens cDNA FLJ30136 fis, GP:AK054698_1 clone BRACE2000077; unnamed R.PSQETTPPDRSHHSGFGLFCGD.P 2 3.176 0.156 P protein product. Homo sapiens cDNA FLJ30536 fis, clone BRAWH2001166, weakly similar IPI:IPI00186241.1 GP:AK055098_1 to BETA-GALACTOSIDASE R.GALNKITLLELEDVPLQPQ.V 2 2.509 0.150 A (96%) PRECURSOR (EC 3.2.1.23); unnamed protein product. Homo sapiens cDNA FLJ30642 fis, IPI:IPI00161430.1 GP:AK055204_1 clone CTONG2002965; unnamed K.EIVEASTRGVSVY.I 2 2.457 0.153 G (95%) protein product. N.PENLKANALYTHSRLSSSL.V 2 2.450 0.169 Homo sapiens cDNA FLJ30959 fis, R.CIVILREIPETTPIEEVKGLFKSENCPKVI IPI:IPI00186272.1 GP:AK055521_1 clone HCASM2000307; unnamed 3 3.559 0.100 A .S (98%) protein product. Homo sapiens cDNA FLJ31172 fis, clone KIDNE2000051, moderately IPI:IPI00171188.1 GP:AK055734_1 N.EKPYICRECGRGFCDK.S 1 1.818 0.115 G similar to ZINC FINGER PROTEIN (99%) 133; unnamed protein product. Homo sapiens cDNA FLJ31174 fis, GP:AK055736_1 clone KIDNE2000085; unnamed F.ETESHSVAQLECSGV.I 2 2.612 0.081 O protein product. Homo sapiens cDNA FLJ31204 fis, IPI:IPI00043550.1 GP:AK055766_1 L.APMLKVMAGPGIK.R 2 2.683 0.080 O clone KIDNE2003305, weakly similar (94%) Supplementary Table 1 108 to PUTATIVE AMIDASE AF1954 (EC 3.5.1.4); unnamed protein product. Homo sapiens cDNA FLJ31400 fis, clone NT2NE1000185, weakly similar to UDP-N-ACETYLGLUCOSAMINE-- IPI:IPI00182322.1 GP:AK055962_1 PEPTIDE N- G.NLLKSQEKKEEAITLLKDSI.K 2 3.102 0.115 P (98%) ACETYLGLUCOSAMINYLTRANSFE RASE 110 KDA SUBUNIT (EC 2.4.1.- ); unnamed protein product. Homo sapiens cDNA FLJ31416 fis, clone NT2NE2000299, moderately IPI:IPI00179047.1 GP:AK055978_1 similar to 69 KD ISLET CELL K.KTARMVSQIHEACIG.F 1 2.079 0.106 A (95%) AUTOANTIGEN; unnamed protein product. Homo sapiens cDNA FLJ31422 fis, clone NT2NE2000384, weakly similar IPI:IPI00152775.1 GP:AK055984_1 to MICRONUCLEAR LINKER K.DRCPLSSSSLEIPD.D 2 2.657 0.099 G, P (95%) HISTONE POLYPROTEIN; unnamed protein product. K.QDRLQYEKTQIKEKDRCP.L 2 3.269 0.218 Homo sapiens cDNA FLJ31432 fis, A.TALPASAPAVSQPTAPAPSCLPKAGQV IPI:IPI00102281.1 GP:AK055994_1 clone NT2NE2000550; unnamed 3 4.089 0.182 O, P IPALLREAPFSSVI.A (92%) protein product. Q.DHNAILDFEHRTCTLKGKK.F 2 2.463 0.162 Homo sapiens cDNA FLJ31440 fis, L.SNSDPFKYNNSTGISYETLGPEELRSLL GP:AK056002_1 clone NT2NE2000763; unnamed 3 4.417 0.240 G TT.Q protein product. Homo sapiens cDNA FLJ31451 fis, R.TRFTWMDGPPHGGLGTRFSGRGSASL GP:AK056013_1 clone NT2NE2000980; unnamed 3 3.634 0.232 P TAPPGR.C protein product. Homo sapiens cDNA FLJ31473 fis, GP:AK056035_1 clone NT2NE2001530; unnamed F.PPKEVKSQTELRKTPVS.E 2 2.482 0.153 G, P protein product. L.LALFMSFLGILCKCPLQ.N 1 2.609 0.117 Homo sapiens cDNA FLJ31503 fis, clone NT2NE2005720, highly similar P.NLAGLQQANRHHGLLGGALANLFVIVG IPI:IPI00163055.1 GP:AK056065_1 3 4.234 0.091 A, O to Mus musculus Ubc6p homolog F.A (95%) mRNA; unnamed protein product. Homo sapiens cDNA FLJ31575 fis, clone NT2RI2001846, moderately IPI:IPI00151987.1 GP:AK056137_1 similar to Basic domain/leucine zipper K.QLECLLTHCIKVPMLVLDPALPA.N 2 2.529 0.144 G (96%) transcription factor; unnamed protein product. Homo sapiens cDNA FLJ31628 fis, clone NT2RI2003344, weakly similar G.DRRSTLHLLQGGDEKKVSGVGKGGQP IPI:IPI00043552.1 GP:AK056190_1 3 3.762 0.171 A to PRESYNAPTIC PROTEIN SAP97; LRHRI.L (91%) unnamed protein product. Homo sapiens cDNA FLJ31673 fis, GP:AK056235_1 clone NT2RI2005061; unnamed Y.DILVSDFDTEEK.M 1 2.218 0.162 G protein product. Homo sapiens cDNA FLJ31726 fis, clone NT2RI2006735, weakly similar IPI:IPI00043516.1 GP:AK056288_1 to Neofelis nebulosa strain nnex zinc L.QTLPLSTLESE.N 1 2.590 0.107 P (98%) finger protein Zfx gene; unnamed protein product. T.HLRRQNLAARGGFVQILTKQP.F 2 3.945 0.163 Homo sapiens cDNA FLJ31894 fis, IPI:IPI00220338.1 GP:AK056456_1 clone NT2RP7003647; unnamed A.GGGGFLYLLTKE.P 1 2.224 0.081 O (92%) protein product. Homo sapiens cDNA FLJ31986 fis, clone NT2RP7008720, weakly similar F.CLKTLNGIQLARNQNGEELYDCKQCED IPI:IPI00043307.1 GP:AK056548_1 3 3.816 0.263 O to ZINC FINGER PROTEIN 84; .V (99%) unnamed protein product. Homo sapiens cDNA FLJ32000 fis, clone NT2RP7009370, weakly similar IPI:IPI00043302.1 GP:AK056562_1 to PUTATIVE SERINE/THREONINE- V.LNNFDFQVQK.F 1 2.399 0.124 P (97%) PROTEIN KINASE PKWA (EC 2.7.1.- ); unnamed protein product. Homo sapiens cDNA FLJ32070 fis, GP:AK056632_1 clone OCBBF1000119; unnamed E.EKGEGTPREEGK.A 2 2.541 0.095 G protein product. Homo sapiens cDNA FLJ32104 fis, GP:AK056666_1 clone OCBBF2001307; unnamed D.PTGQPGAPQLTQNIPRGPAGSKV.F 2 2.466 0.114 P protein product. L.VITMAAGKGAPLSPSAENRWRL.S 2 2.759 0.124 GP:AK056789_1 Homo sapiens cDNA FLJ32227 fis, E.DSLLASQEALRYYRR.K 2 2.762 0.123 G, O IPI:IPI00217741.1 Supplementary Table 1 109 clone PLACE6004396; unnamed (97%) protein product. S.HDEISILSPLSQCCMI.K 2 2.403 0.141 Homo sapiens cDNA FLJ32363 fis, GP:AK056925_1 clone PUAEN1000081; unnamed N.KAPKDKLVEKTGK.I 1 1.912 0.091 G, P protein product. V.LPRALSLSCPVPHL.H 1 2.301 0.123 Homo sapiens cDNA FLJ32430 fis, clone SKMUS2001129, weakly similar IPI:IPI00217420.1 GP:AK056992_1 to NAD-DEPENDENT METHANOL I.WAIHALRIVAKYLKR.A 1 1.897 0.121 P (97%) DEHYDROGENASE (EC 1.1.1.244); unnamed protein product. Homo sapiens cDNA FLJ32467 fis, clone SKNMC2000097, moderately IPI:IPI00181397.1 GP:AK057029_1 similar to M.musculus mRNA for A.LEEVEKEGAGAAT.G 2 2.421 0.143 O, P (91%) protein Htf9C; unnamed protein product. E.FLVGVGVDGEDNTVGCRLGKYK.G 2 2.215 0.169 Homo sapiens cDNA FLJ32506 fis, clone SMINT1000042, weakly similar IPI:IPI00216702.1 GP:AK057068_1 to ATP-BINDING CASSETTE, SUB- D.PQVLLLDEPTAGLDPLSRHR.I 2 3.918 0.095 G, O, P (92%) FAMILY A, MEMBER 3; unnamed protein product. M.VFTLFLLYGLSLITLA.F 1 2.261 0.100 Homo sapiens cDNA FLJ32618 fis, GP:AK057180_1 clone STOMA2000289; unnamed I.QLCKDIMDLKQELQNLVAIPEKEK.T 3 3.676 0.092 O protein product. Homo sapiens cDNA FLJ32642 fis, GP:AK057204_1 clone SYNOV2001144; unnamed K.QIITDKDDLVK.S 1 2.539 0.080 G protein product. Homo sapiens cDNA FLJ32661 fis, clone TESTI1000055, weakly similar IPI:IPI00065462.1 GP:AK057223_1 P.EQVYNWFANYR.R 1 2.094 0.115 P to HOMEOBOX PROTEIN SIX1; (96%) unnamed protein product. Homo sapiens cDNA FLJ32682 fis, clone TESTI2000044, weakly similar GP:AK057244_1 E.EYLGKEEYLKEEEYLGK.E 2 2.516 0.102 A, P to TRICHOHYALIN; unnamed protein product. R.REAQKLTEMTSFT.F 2 2.505 0.148 Homo sapiens cDNA FLJ32732 fis, clone TESTI2001141, highly similar to IPI:IPI00065435.1 GP:AK057294_1 Rattus norvegicus actin-filament F.LLPELEK.R 1 1.907 0.101 O, P (98%) binding protein Frabin mRNA; unnamed protein product. K.GFDNAMELVKNMTERIPQFKSVVE.E 2 2.501 0.123 Homo sapiens cDNA FLJ32748 fis, clone TESTI2001556, weakly similar IPI:IPI00179346.1 GP:AK057310_1 S.ISVIKNPTV.F 1 2.118 0.111 G to ZINC FINGER PROTEIN 151; (99%) unnamed protein product. Homo sapiens cDNA FLJ32795 fis, clone TESTI2002461, weakly similar IPI:IPI00065153.1 GP:AK057357_1 Y.EDALNK.L 1 1.855 1.000 O to TRICHOHYALIN; unnamed protein (93%) product. Homo sapiens cDNA FLJ32880 fis, GP:AK057442_1 clone TESTI2004122; unnamed A.QRKLEELRRQERQRFAE.Y 2 2.603 0.217 O protein product. Homo sapiens cDNA FLJ32926 fis, IPI:IPI00065354.1 GP:AK057488_1 clone TESTI2007358; unnamed V.EKLVELQE.Q 2 2.856 0.085 O (93%) protein product. Homo sapiens cDNA FLJ32934 fis, IPI:IPI00180488.1 GP:AK057496_1 clone TESTI2007480; unnamed K.IKAIARKTKEVADRVR.K 2 2.833 0.200 P (96%) protein product. Homo sapiens cDNA FLJ32978 fis, IPI:IPI00065416.1 GP:AK057540_1 clone TESTI2017740; unnamed I.IQVIYVEE.K 1 2.358 0.114 P (94%) protein product. Homo sapiens cDNA FLJ33069 fis, IPI:IPI00065392.1 GP:AK057631_1 clone TRACH2000196; unnamed K.GTRRLDTDH.C 1 2.111 0.128 G (95%) protein product. Homo sapiens cDNA FLJ33084 fis, GP:AK057646_1 clone TRACH2000411; unnamed R.APLGPQDLR.L 1 1.939 0.132 P protein product. Homo sapiens cDNA FLJ33086 fis, IPI:IPI00182031.1 GP:AK057648_1 clone TRACH2000461; unnamed L.EDHPGHSSQAPIPRADPLPKSTVLFS.G 2 2.740 0.237 P (98%) protein product. Homo sapiens cDNA FLJ25168 fis, L.PPSHGKEGGKEAKVPSGDNSGRGEVP GP:AK057897_1 3 3.828 0.135 P clone CBR08585; unnamed protein RAQEGQAACGRAASGDSQ.E Supplementary Table 1 110 product. Homo sapiens cDNA FLJ25205 fis, clone REC05844, highly similar to IPI:IPI00061460.1 GP:AK057934_1 W.AIEKNLTPVPGAPSQ.T 1 2.181 0.099 G Mus musculus F-box protein FBX17 (93%) mRNA; unnamed protein product. Homo sapiens cDNA FLJ25357 fis, IPI:IPI00217866.1 GP:AK058086_1 clone TST01690; unnamed protein T.HWKVYVIARGVQPLVI.C 2 2.444 0.213 G, O (93%) product. W.WTNDCEQNESEPIPANCTGC.A 2 3.669 0.158 Homo sapiens cDNA FLJ25378 fis, GP:AK058107_1 clone TST02085; unnamed protein Q.SQDARPLAPAACISKIAKAGRELPGR.H 2 2.609 0.113 A product. Homo sapiens cDNA FLJ25390 fis, GP:AK058119_1 clone TST02370; unnamed protein F.AERLSEGRNAPHYHVVK.W 1 2.042 0.135 A product. Homo sapiens cDNA FLJ25415 fis, IPI:IPI00065071.1 GP:AK058144_1 clone TST03443; unnamed protein G.SICIGYLLKSR.L 1 1.828 0.168 G (94%) product. Homo sapiens cDNA FLJ25426 fis, clone TST04705, highly similar to GP:AK058155_1 Rattus norvegicus testis specific G.KIRQRIMPVRNFSKFSDCTR.A 3 3.663 0.083 A protein mRNA; unnamed protein product. Homo sapiens cDNA FLJ25442 fis, GP:AK058171_1 clone TST08489; unnamed protein R.LPSISSTTCG.R 1 1.883 0.113 A product. Human DNA sequence from clone XXbac-24o18 on chromosome 6p21.31-22.2. Contains a zinc finger protein pseudogene, a pseudogene A.QPAFISTTQSALGCLTPSASTSQTPAS. GP:AL021808_2 similar to rodent vomeronasal 2 2.708 0.202 P T pheromone receptor genes, the POM121L2 gene for POM121 membrane glycoprotein (rat homolog)- lik Homo sapiens DNA sequence from PAC 434O14 on chromosome 1q32.3.-41. Contains the HSD11B1 gene for Hydroxysteroid (11-beta) GP:AL022398_2 I.QQREQLQRARLQ.Q 1 2.070 0.203 G, O Dehydrogenase 1, the ADORA2BP adenosine A2b receptor LIKE pseudogene, the IRF6 gene for Interferon Regulatory Factor 6 and two W.SPKSFPNEVEPEGTGKEK.D 2 2.804 0.154 Y.EALKEDWR.T 2 2.577 0.175 Human DNA sequence from clone 97P20 on chromosome 1q23.2-24.3 Contains a novel gene, a novel IPI:IPI00218033.1 GP:AL031297_1 D.LSLEGDPFSQPIKFPI.N 2 3.540 0.105 A, G mRNA, ESTs, STSs and GSSs, (94%) complete sequence; match: proteins: Sw:O13733. I.LLALIFLH.D 1 2.167 0.115 Human DNA sequence from clone RP5-1163J1 on chromosome 22q13.2-13.33 Contains the 3' part of a gene for a novel KIAA0279 LIKE GP:AL031588_1 F.VIGINQTENPFLCTVVAILLH.Y 2 2.852 0.081 G EGF-like domain containing protein (similar to mouse Celsr1, rat MEGF2), a novel gene for a protein similar to C. elegans B0 Human DNA sequence from clone RP3-353E16 on chromosome 22q11.22-12.3 Contains the 5' part of the MN1 gene for meningioma GP:AL031591_1 G.HFDMFSPSDSEGQLPHYAAGRQV.P 2 2.964 0.094 G, P (disrupted in balanced translocation) 1, the PITPNB gene for phosphatidylinositol transfer protein beta, ESTs, STSs, GSSs and two R.KLSQNETDGAAVAGNPG.S 1 1.929 0.092 S.pombe chromosome III cosmid c1183; SPCC1183.05c, len:923, C term may be incorrectly pre dicted., GP:AL031740_5 SIMILARITY:Homo sapiens, A.YRTFPGAFTVGDVNALLDQL.A 2 2.436 0.104 O, P DNL4_HUMAN, dna ligase iv , (844 aa), fasta scores: opt: 977, E():0, (32.0% identity in 694 aa). Supplementary Table 1 111 E.YMELAGTKQDFEKPDMWIHPK.D 2 2.230 0.308 S.YLLFSKDEK.Y 1 1.994 0.081 Human DNA sequence from clone 34B21 on chromosome 6p12.1-21.1. Contains part of a gene for a novel protein with ZU5 domain similar to part GP:AL031778_1 R.GGCLMLQD.T 1 2.204 0.118 G of Tight Junction Protein ZO1 (TJP1) and UNC5 Homologs, the gene for a novel BZRP (peripheral benzodiazapine re S.LILVWDLSDAPSLSQAQGLVSPVVACG 3 4.011 0.083 PHGASFL.K Human DNA sequence from clone RP5-998C11 on chromosome 20q13.13-13.2 Contains part of the KIAA1415 gene, ESTs, STSs and IPI:IPI00218429.1 GP:AL035106_1 GSSs, complete sequence; continues K.VLFSNIEDILEVHK.D 2 2.526 0.162 O (99%) from dJ906C1 (AL133342) in bA269H4 (AL445192) match: cDNAs: Em:AB037836 Em:AL137289 Em:AB029035 S.pombe chromosome I cosmid c1296; SPAC1296.01c, len:276, SIMILARITY:Homo sapiens, GP:AL035439_1 G3851711, n-acetylglucosamine- F.PIEIVNDNIDN.P 2 2.639 0.082 G phosphate mutase., (542 aa), fasta scores: opt: 519, E():8.9e-28, (39.0% identity in 241 aa). Human DNA sequence from clone RP5-995J12 on chromosome 20q12 Contains part of a gene similar to ganglioside-induced differentiation GP:AL035462_1 A.SLELRGANPR.G 2 2.652 0.149 G, P associated protein 1, a putative novel gene, ESTs, STSs, GSSs and a CpG Island, complete sequence; match: ESTs: Em:BF3 Human DNA sequence from clone RP5-1175I6 on chromosome 20. Contains the 3' end of the gene for Ras inhibitor JC265 (Ras association GP:AL049538_1 V.LPKLVKSQLQK.V 1 1.823 0.084 G (RalGDS/AF-6) domain containing protein), the 5' end of the gene encoding N-terminal acetyltransferase complex ard1 su Human DNA sequence from clone RP1-34F7 on chromosome 6p21.2- 21.33 Contains the 3' end of the gene for CREB-RP (G13), the gene for IPI:IPI00032258.2 GP:AL049547_8 F.SVVPTAATAVSLK.V 2 2.753 0.267 G, P tenascin XB and XA, the CYP21A2 (94%) gene for cytochrome P450, subfamily XXIA (steroid 21-hydroxylase), polypeptide 2 (CYP21, R.PVAFSVVPTAATAVSLK.V 2 4.001 0.391 Human DNA sequence from clone RP4-734P14 on chromosome 20. Contains the 3' end of a novel KRAB box protein gene, a novel C2H2 zinc D.DLLEPATKPSIAGKFKVLEPPMLGHDL. GP:AL049650_6 3 3.961 0.099 O finger domain protein gene, the R SNRPB gene for small nuclear ribonucleoprotein polypeptides B and B1 (B') and the 3' en Novel human mRNA from IPI:IPI00010814.1 GP:AL049689_1 Q.EVAEVTVPKSSDPK.S 2 2.754 0.081 P chromosome 1, similar to Tenascin-R. (97%) V.TPQGLQLLKNT.E 2 2.409 0.112 Human DNA sequence from clone 99E18 on chromosome 6q25.1-26 Contains part of a gene similar to methylenetetrahydrofolate T.PKAVDVLAKEIGLLADEIEIYGKSKAKVR IPI:IPI00185420.1 GP:AL049694_1 3 3.794 0.117 A, G dehydrogenase (NADP+ dependent), LSVL.E (92%) methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase, a pseudogene similar V.LAKEIGLLADEIEIYGK.S 1 1.944 0.084 Human DNA sequence from clone RP4-686C3 on chromosome 20. GP:AL049712_6 I.IVIRSMASNTQGSTGEGESDNFTFSF.K 2 2.928 0.202 P Contains the IDH3B gene for isocitrate dehydrogenase 3 (NAD+) beta A and Supplementary Table 1 112 B, the gene for nucleolar protein NOP56, a novel gene, ESTs, STSs, GSSs and three CpG islands, complete sequence; gene Novel human gene mapping to L.EHQLSEVALQTALASSSRHYAGRSFQI GP:AL049784_1 2 2.423 0.154 O, P chomosome 13. FRA.L Q.GYVMEALLTLEAAVDNLSDCL.K 2 2.778 0.122 V.SSMPELLNMSRELSD.L 2 2.727 0.085 W.SEPTFTSTEAAIQ.S 2 2.468 0.113 Human DNA sequence from clone RP5-889J22 on chromosome 22q13.1 IPI:IPI00002313.2 GP:AL049851_1 I.RNLLDLPSSRLDFQVC.P 1 2.419 0.142 G Contains the 3' part of a novel gene, (99%) ESTs and a GSS, complete sequence. Human DNA sequence from clone 486I3 on chromosome 6q22.1-22.3. Contains the part of a gene for a novel protein, the gene for KIAA0721 (NAP GP:AL050331_3 D.AAGRGGTPQIRVVGGRGHVAIKA.G 2 2.428 0.108 G, O (Nucleosome Assembly Protein) domain containg protein), the TSPYL gene for TSPY-like (testis specific protein, R.SASELTAGAEAEAEEVKT.G 2 2.930 0.139 Human DNA sequence from clone RP4-570F3 on chromosome 6. Contains the 5' end of the gene for the ortholog of the rat synaptic ras IPI:IPI00027032.1 GP:AL050332_7 G.ELDPMVPVRFGAL.M 1 2.690 0.107 O GTPase-activating protein p135 (94%) SynGAP, gene LOC51596 for divalent cation tolerant protein CUTA or brain acetylcholineste K.DLAILQ.C 1 1.911 1.000 Human DNA sequence from clone RP1-39G22 on chromosome 1p32.1- 34.3. Contains the 3' part of the RLF gene for rearranged L-myc fusion IPI:IPI00018294.1 GP:AL050341_1 H.CIHKTCNSSFTNLKGLIRHYR.T 2 2.343 0.102 G sequence (ZN-15 related zinc finger (95%) protein), a novel gene, the ZMPSTE24 gene for yeast zinc metalloproteinase STE24 h I.EPSLDGFNMLEELYLQPDQK.F 2 2.658 0.107 Homo sapiens mRNA full length insert GP:AL079313_1 K.ELNLHELCAVCLEDFKP.R 3 3.597 0.227 A cDNA clone EUROIMAGE 566628. Homo sapiens mRNA; cDNA DKFZp434K063 (from clone L.SITDDYDNHTGIDLVGTIIATIKGSNEED IPI:IPI00024415.1 GP:AL080138_1 3 3.788 0.122 A DKFZp434K063); partial cds; TD.T (99%) KIAA0650 partial sequence. Human DNA sequence from clone RP1-122O8 on chromosome 6q14.2- 16.1. Contains the 3' part of a novel gene partially coded for by KIAA0301, IPI:IPI00167941.1 GP:AL096678_4 L.LRATKLKKPILLEGSPGVGKTSLVGA.L 2 2.733 0.176 G a novel gene and the 3' part of the (96%) gene KIAA0957. Contains ESTs, STSs, GSSs and a putative CpG island, complete Human DNA sequence from clone RP4-744I24 on chromosome 6p12.1- 21.2 Contains a novel gene (KIAA0646 (new zinc finger protein)), GP:AL096712_2 R.ESSSSSSSSEA.Q 1 2.346 0.229 A part of a novel gene (similar to a novel human gene mapping to chomosome 22q13.3 similar to yeast ORF YOR070C, putative GT Novel human gene mapping to IPI:IPI00009586.1 GP:AL096777_1 T.CGKKGSQAGAEGQPSTVK.R 2 2.385 0.113 P chomosome X. (98%) T.SSPFVIFPEIVR.N 1 2.238 0.092 Human DNA sequence from clone RP1-237H22 on chromosome Xq23- GP:AL109751_1 24 Contains the gene for HOM-TES- L.IATQKDLIATQRDLI.A 2 2.820 0.195 G, O 85 tumor antigen, an EST and a CpG island, complete sequence. M.ASFRKLTLSEKVPPNHPSRKKVNFLDM 3 3.835 0.207 SL.D Human DNA sequence from clone RP1-321O10 on chromosome Xq13.1- GP:AL109752_1 K.LEDGSKFL.K 1 1.979 0.105 A, G, P 21.2 Contains part of a gene similar to EEF1A1 (eukaryotic translation Supplementary Table 1 113 elongation factor 1 alpha 1), part of a gene similar to DACH (dachshund (Drosophila) homolog), ESTs, STSs ans a CpG I R.CGNIAGDSKNGPPMKAAGITAQVIILNH 2 2.784 0.262 .P Human DNA sequence from clone RP4-551D2 on chromosome 20q13.2- 13.33 Contains the gene for a cadherin-like protein VR20, a novel GP:AL109928_2 L.ICTAAAGPTQGVKGYGKPFEPRS.V 2 3.002 0.086 G gene, the PPP1R6 gene for protein phosphatase 1 regulatory subunit 6, the 5' end of the SYCP2 gene for synaptonemal comple Human DNA sequence from clone RP4-794I6 on chromosome 20 Contains a putative oncogene (HLC14-06-P), the 3' end of a novel IPI:IPI00181175.1 GP:AL109976_3 L.YSSNLQSWPE.E 2 2.605 0.127 O, P gene, the gene for a novel protein (96%) similar to solute carrier family 4 anion exchanger 1 (SLC4A1), ESTs, STSs, GSSs and CpG islan R.SSLKLLSAKLPELDW.F 2 2.810 0.115 Human DNA sequence from clone RP11-494O16 on chromosome 22. Contains the gene KIAA0637, ESTs, IPI:IPI00006610.1 GP:AL117328_1 A.HWVSFESPA.R 1 2.210 0.101 G GSSs and two putative CpG islands, (92%) complete sequence; match: proteins: Tr:O75132. F.SHTVNLIVSEAIKSQRMVQNLLS.L 2 2.579 0.139 Human DNA sequence from clone RP5-876B10 on chromosome 1q42.12-43. Contains the 3' end of the GNPAT gene for glyceronephosphate A.AAAGAAAASGGEEGVGGAGGRDHLR. GP:AL117352_2 2 2.586 0.120 A, P O-acyltransferase (DHAPAT, DAPAT, G dihydroxyacetone phosphate acyltransferase, EC 2.3.1.42), the gene for a novel protein ( M.FPESRIFQAENA.K 2 2.509 0.175 Streptomyces coelicolor cosmid F41; SCF41.21, possible racemase, len: 403 aa. Weakly similar to Eukaryotic and Prokaryotic racemases e.g. Homo GP:AL117387_21 A.FPPLKRLGEILGEDTFL.A 2 2.848 0.264 G sapiens (Human) TR:O43673 (EMBL; AF047020) alpha-methylacyl-coA racemase (EC 5.1.99.4) (382 aa), fasta scor Human DNA sequence from clone RP1-190I16 on chromosome 1q23-24 Contains ESTs, GSSs and STSs. Contains part of the gene for an Smg GP:AL121714_1 E.LISFCINLAANKRNVQLICEGN.G 2 3.042 0.112 O, P GDS-associated protein (SMAP), complete sequence; match: proteins: Tr:P70188 Tr:Q92845 Tr:Q26626 Tr:Q9VZ07. N.DEEEEFVIECLGTLANL.T 2 2.603 0.112 Human DNA sequence from clone RP1-202D23 on chromosome 6q14.1- 15 Contains part of the gene for N- acetylglucosamine-phosphate mutase, IPI:IPI00010903.1 GP:AL121716_2 H.KDKKIRMEAHAK.F 1 2.216 0.156 G the 3' part of a gene for a novel protein (94%) similar to C21ORF5 (KIAA0933), ESTs, STSs and GSSs, complete sequence; cont L.TQSVAMVTGE.N 1 2.053 0.132 Human DNA sequence from clone RP5-852M4 on chromosome 20. Contains the gene encoding the HBV associated factor, a novel gene similar R.ERQLRMLEDLGFKDLTLQPRGPLEPG. IPI:IPI00183994.1 GP:AL121747_1 2 2.551 0.216 A to Drosophilia CG17883, a putative P (92%) novel gene, two CpG islands, ESTs, GSSs, and STSs, complete sequence; match: prote Human DNA sequence from clone RP4-726C3 on chromosome 20 GP:AL121756_1 E.MEAMSDEQKMAQK.I 2 2.210 0.130 A, O Contains the ortholog of potential ligand_binding protein RYA3 (Rat), the Supplementary Table 1 114 ortholog of potential ligand_binding protein RY2G5 (Rat), the 5' end of a gene similar to SPAG4 (sperm associated antib P.NMNDNILLPVRNND.Q 2 3.273 0.131 Human DNA sequence from clone RP4-726C3 on chromosome 20 Contains the ortholog of potential ligand_binding protein RYA3 (Rat), the GP:AL121756_6 G.GGLLGDGGLL.G 1 2.015 0.081 O ortholog of potential ligand_binding protein RY2G5 (Rat), the 5' end of a gene similar to SPAG4 (sperm associated antib Human DNA sequence from clone RP1-92C4 on chromosome 6q14.1-15 Contains ESTs, STSs and GSSs. GP:AL132875_1 R.LVLIIYNFGMVLLN.L 1 1.927 0.189 A, G Contains the 3' part of a novel gene, complete sequence; match: proteins: Tr:Q9Y3M0 Tr:Q9WU14 Tr:Q9Y396. V.WLGPKWMKDR.E 1 1.942 0.122 Human DNA sequence from clone RP5-867F11 on chromosome 20. Contains the TCF15 (transcription factor 15 (basic helix-loop-helix)) GP:AL133231_1 A.NVLLLGDSADDGQPCFR.A 1 2.266 0.131 P gene, ESTs, STSs, GSSs and a CpG island, complete sequence; match: proteins: Tr:O13112 Tr:Q60756 Tr:P79782 Tr:Q60539 Tr:Q Human DNA sequence from clone RP11-446H13 on chromosome 10. Contains the 3' end of the gene for a novel protein similar to KIAA1059 IPI:IPI00103597.2 GP:AL133395_1 V.LPYQDPAGENKRSTDDLE.Q 2 3.570 0.109 A, P (ortholog of mouse VPS10 domain (99%) receptor protein SORCS), an RPL23A (60S ribosmal protein 23A) pseudogene, ESTs, STSs a Human DNA sequence from clone GS1-174L6 on chromosome 1 Contains part of the gene for TPR (translocated promoter region (to GP:AL133553_2 F.KGFGGLTGQ.I 1 2.061 0.120 A, O, P activated MET oncogene)), a gene for a novel protein (MSF: megakaryocyte stimulating factor), ESTs, STSs and GSSs, complete se G.YPKPIFKGFGGLTGQIVAALSTAKYK.N 2 2.427 0.239 K.DAGYPKPIFK.G 2 2.701 0.224 K.DQYYNIDVPSR.T 2 2.446 0.102 K.GFGGLTGQIVAALSTAK.Y 2 3.183 0.363 K.SEDAGGAEGETPHMLLRPHVFMPEVT 3 5.094 0.407 PDMDYLPR.V R.AIGPSQTHTIR.I 2 2.875 0.328 R.GLPNVVTSAISLPNIR.K 2 5.025 0.405 R.ITEVWGIPSPIDTVFTR.C 2 2.341 0.349 R.KPDGYDYYAFSK.D 2 3.198 0.386 Human DNA sequence from clone RP5-1126E12 on chromosome GP:AL136112_1 Xq22.1-22.3. Contains a novel gene, I.GPPQIEELKVIPETSEENNEDI.W 2 3.046 0.119 P ESTs, GSSs and a putative CpG island, complete sequence. Human DNA sequence from clone RP3-376F14 on chromosome 6q12-13 Contains part of the COL19A1 gene for collagen type XIX alpha 1. I.PGEKGDEGLQGIPGIPGAPGPTGPPGL GP:AL136445_1 2 2.328 0.117 A, O Contains STSs and GSSs, complete MGR.T sequence; continues in dJ257B21 and dJ138F4 match: cDNAs: Em:D38163 Em:AB000636 Em:L12347 K.SLPGEPGLDGNPGAPGPRG.P 1 2.161 0.160 P.TGPPGLMGRTGHPGPTGAKGEK.G 2 2.305 0.122 S.LPGEPGLDGNPGAPGPRGPKGER.G 2 2.217 0.130 Homo sapiens mRNA; cDNA DKFZp564B1023 (from clone IPI:IPI00217157.1 GP:AL136611_1 DKFZp564B1023); complete cds; F.VPRSLKIKRNANDDGK.S 1 2.323 0.087 G (96%) strong similarity to rat RNA helicase HEL117. Supplementary Table 1 115 2 2.838 0.085 S.CPFPSPGGQLAEVHSVSPEQGAK.D 2 2.693 0.123 Homo sapiens mRNA; cDNA DKFZp564N1062 (from clone GP:AL136651_1 DKFZp564N1062); complete cds; K.KLKLENGGLVRENLRL.K 1 2.617 0.152 G similarity to reticulocyte-binding protein. Homo sapiens mRNA; cDNA DKFZp434H2010 (from clone R.SGDAAANKLFHYIPGTDILDLENQRENL IPI:IPI00030240.1 GP:AL136730_1 3 3.937 0.097 G DKFZp434H2010); complete cds; EQP.F (91%) unknown protein. Homo sapiens mRNA; cDNA DKFZp434G1415 (from clone GP:AL136759_1 F.LAIKLGVIPS.D 1 2.057 0.098 A DKFZp434G1415); complete cds; similarity to YOR243c. Homo sapiens mRNA; cDNA DKFZp434F1726 (from clone DKFZp434F1726); similarity to IPI:IPI00178318.1 GP:AL136818_1 G.WTSNPEELDPIR.L 2 2.902 0.226 P interferon-gamma receptor segment (93%) binding interferon-gamma (Homo sapiens). Homo sapiens mRNA; cDNA DKFZp434G2226 (from clone IPI:IPI00171768.1 GP:AL136819_1 K.QYCTLKEAGLSNAAFESDFKEI.E 2 2.522 0.102 A DKFZp434G2226); complete cds; (91%) strong similarity to kinesins. Homo sapiens mRNA; cDNA DKFZp434O194 (from clone P.NTSGSIHENPPKAKATVNVKQAAKVVK IPI:IPI00166700.1 GP:AL136867_1 DKFZp434O194); complete cds; 2 2.939 0.106 G A.S (95%) similarity to megakaryocyte stimulating factor and mucin. Homo sapiens mRNA; cDNA DKFZp434P144 (from clone IPI:IPI00183244.1 GP:AL136868_1 DKFZp434P144); complete cds; E.AKEYDLAKK.Y 1 2.042 0.178 A, G (98%) nearly identical to Nup358/RanBP2 N- terminus. S.FYGQLEYIGRSVHY.W 2 2.428 0.199 S.FYGQLEYIGRSVHYWK.K 2 2.931 0.085 Homo sapiens mRNA; cDNA DKFZp434N127 (from clone GP:AL136893_1 M.GSGDPRKPRQLTVGDAR.L 1 2.336 0.164 G DKFZp434N127); complete cds; putative protein. Homo sapiens mRNA; cDNA DKFZp586J1119 (from clone IPI:IPI00152642.1 GP:AL136919_1 DKFZp586J1119); complete cds; E.KFVVDKSTAGALDK.K 2 2.728 0.099 P (98%) strong similarity to KIAA0231, similarity to ras binding protein Sur8. Human DNA sequence from clone RP11-139H14 on chromosome 13 Contains the LCP1 (lymphocyte cytosolic protein 1 (L-plastin)) gene, IPI:IPI00009021.1 GP:AL137141_2 A.FQSGQVLAALPR.T 2 3.922 0.315 O, P part of the gene for CPB2 (99%) (carboxypeptidase B2 (plasma)), ESTs, STSs, GSSs and a CpG Island, complete sequence; match: pro Human DNA sequence from clone RP1-139G21 on chromosome 6. Contains (part of) the SLC17A1, SLC17A2 and SLC17A3 genes for the IPI:IPI00220149.1 GP:AL138726_5 I.VLLIVTRIVQGLSQSSILGGQFA.I 2 3.387 0.090 O, P sodium phosphate solute carrier family (98%) 17 members 1, 2 and 3 and a H2A (histone 2A) pseudogene, ESTs, STSs and GSSs, complete Human DNA sequence from clone RP11-16H23 on chromosome 10. Contains the gene KIAA0204 (HSLK) for a protein kinase, the COL17A1 GP:AL138761_3 L.QGPPGPPGPRGPPGPSIPGPPGPR.G 2 2.218 0.127 G, P gene for collagen type XVII alpha 1 (BP180), ESTs and GSSs, complete sequence; match: proteins: Tr:Q07563. P.GPPGASGDGSLLSLDYAELSSRI.L 2 2.541 0.157 Human DNA sequence from clone RP11-445O16 on chromosome Xp11.1-11.22 Contains part of a novel IPI:IPI00174535.1 GP:AL139397_1 V.IDSLVGK.Q 1 1.891 0.099 O gene, a paeudogene, and a CpG (95%) island, complete sequence; match: cDNAs: Em:AF317228 Em:AF106682 Supplementary Table 1 116 Em:U48972 match: ESTs: Em:BE410666 Em:BE280284 Em:AW862988 Em Leishmania major Friedlin chromosome 5 cosmid L8325; L8325.05, len = 940 aa, unknown; potential coiled-coil region aa 890- GP:AL157415_5 L.LLSPENQSLAQ.V 1 2.548 0.080 O, P 900; weak similarity to O43162 kiaa0435 (777 aa, Homo sapiens, EMBL: AB007895, BAA23708); Fasta scores: E():1.3, 26.4% identity L.SPENQSLAQ.V 1 2.760 0.086 Human DNA sequence from clone RP5-884F15 on chromosome 20 Contains the 3' part of the SYCP2 gene for synaptonemal complex IPI:IPI00003403.2 GP:AL158092_1 K.HIKTAKCVEN.T 1 1.867 0.147 G, O, P protein 2, ESTs and STSs, complete (94%) sequence; continued from dJ551D2 (AL109928) match: proteins: Tr:O70608. N.FEKDSQSLKDLEKEFV.D 2 2.818 0.090 Human DNA sequence from clone RP11-351K23 on chromosome X Contains the 3' end of the IGBP1 gene for immunoglobulin binding protein 1 GP:AL158141_3 G.ACSVSRSSIDFLLTHK.G 2 2.641 0.083 O (CD79A), a NADH dehydrogenase (ubiquinone) pseudogene, a cytochrome B pseudogene, a novel gene, part of a novel gene, Novel human gene mapping to IPI:IPI00007770.1 GP:AL162331_1 L.EFSDVKLLAE.S 1 2.096 0.160 P chomosome 1. (95%) Homo sapiens chromosome 21 segment HS21C079; hypothetical 76.5 IPI:IPI00030741.1 GP:AL163279_5 kD protein, O95447, myosin heavy F.AMSLADLTKTNI.D 2 2.669 0.105 G, P (93%) chain and kinesin homology, confirmed by RT-PCR. L.LLRLFAMSLADLTKTNI.D 1 2.672 0.120 Streptomyces coelicolor cosmid C105; SCC105.08, fabG, acetyl/propionyl CoA carboxylase alpha subunit, len: 646 aa; similar to SW:PCCA_HUMAN GP:AL163641_8 A.VFSDADADAR.H 2 2.400 0.212 G, O, P (EMBL:X14608) Homo sapiens propionyl-CoA carboxylase alpha chain precursor (EC 6.4.1.3) PccA, 703 aa; fasta sc L.LVVEAMK.M 1 2.152 0.224 T.APMPGTVTVVKVAVGDE.V 2 3.221 0.271 Leishmania major Friedlin cosmid L5213T; L5213T.07, len = 757 aa, unknown; carboxyl terminus has some similarity to CMGA_HUMAN, A.AHMEVCRVCRGELSPAHASSPLAATL GP:AL352992_7 3 4.182 0.131 G chromogranin a precursor (457 aa, G.E Homo sapiens, EMBL: U03747, AAB53685); Fasta scores: E():0.16, 30.9% identity in 139 aa. Human DNA sequence from clone RP11-384D7 on chromosome 20 Contains the 5' part of the gene encoding DKFZ434P106 protein, the A.AALDADCRLKQNLRLTGPAAAEPRCAA IPI:IPI00060569.1 GP:AL353812_1 3 3.845 0.223 G 5' part of the KIAA0186 gene, a DAGMKRALGRR.K (92%) cyclophilin pseudogene, ESTs, STSs, GSSs and three CpG islands, complete sequence; continues Human DNA sequence from clone RP11-195O1 on chromosome 10 Contains two novel (pseudo)genes, GP:AL354750_2 the 5' end of a gene for a novel protein M.VENKDSVTKV.Q 2 3.658 0.125 G, O, P and 2 CpG islands, complete sequence; continues as bA453G10.1 in Em:AL356053. Human DNA sequence from clone RP11-517O1 on chromosome X Contains a novel gene for a protein IPI:IPI00158517.3 GP:AL355476_1 similar to SA2 nuclear protein, ESTs, R.QAAECHPPVGRGTGKRV.L 2 2.536 0.094 P (94%) STSs and GSSs, complete sequence; match: proteins: Tr:Q62523 Tr:O08982 Tr:O00539 Tr:O00540 Supplementary Table 1 117 Tr:O35638 Tr:Q9UJ98 Tr:O7057 S.pombe chromosome I cosmid c688; SPAC688.09, len:349, SIMILARITY:Homo sapiens, BAA91715, cdna flj10618 fis, clone GP:AL355632_8 E.IKPSENSQKTKVLLTK.A 1 1.836 0.105 A, G nt2rp2005465, weakly similarity to mitochondrial carrier protein rim2., (310 aa), fasta scores: opt: 505, E():5.9e-26, (36.3% identity S.INGTPKYTGLIQCFKLV.W 1 2.278 0.106 Neurospora crassa DNA linkage group II BAC clone B2O8; similarity to GP:AL355930_20 N.ASRQASINVGESSR.Q 2 2.491 0.127 G profilaggrin, Homo sapiens, TREMBL:HSPROFILA_1. N.ASRQASINVGESSRQASATA.G 1 2.580 0.229 Human DNA sequence from clone RP1-14N1 on chromosome 1q21.1- 21.3 Contains ESTs, GSSs and STSs. Contains the FLG gene for profilaggrin IPI:IPI00218610.1 GP:AL356504_2 R.KGNKGRSKSPR.E 2 2.571 0.112 P and part of a gene for a novel S- (94%) 100/ICaBP type calcium binding domain protein similar to trichohyalin.n, complete s R.KGYSPTHREEE.Y 2 2.680 0.335 Streptomyces coelicolor cosmid 4G10; SC4G10.08c, possible long-chain- fatty-acid-CoA ligase, len: 636 aa. Highly similar to many proposed long- GP:AL356932_8 T.ETSGGLTMQPLGR.E 2 2.545 0.103 G chain-fatty-acid-CoA ligases including: Homo sapiens SW:LCFB_HUMAN(EMBL:D10040) long-chain-fatty-acid--CoA l Streptomyces coelicolor cosmid 7E4; SC7E4.20, probable cytochrome P450, len: 461 aa; similar to SW:CP51_HUMAN (EMBL:U23942) GP:AL359214_20 R.RQRRTIQPAFRLDAI.P 1 2.287 0.100 G Homo sapiens cytochrome P450 51 (EC 1.14.14.1) Cyp51, 503 aa; fasta scores: opt: 532 z-score: 587.2 E(): 3.1e-25; 25.7% identi Leishmania major Friedlin chromosome 14 PAC P1295; P1295.14, len = 1039 aa, unknown; some similarity to Q9UQ36, RNA GP:AL359773_14 H.FAAFRASKAGVVHVVQDTAPTWHER.A 2 2.214 0.124 O, P binding protein (1275 aa, Homo sapiens, EMBL: AB016091, BAA83717); Fasta scores: E():0.024, 21.7% identity in 899 aa. P.NTVTAAPHNLGGQGDDSGGGGGDDD 2 4.031 0.172 D.V Leishmania major Friedlin chromosome 21 cosmid L3302; L3302.04, len = 701 aa, unknown; some similarity to FXC1_HUMAN, GP:AL359781_4 T.PTSQKDQAAATVTLGAGR.A 2 2.992 0.109 P forkhead box protein c1 (553 aa, Homo sapiens, EMBL: AF078096, AAC72915); Fasta scores: E():0.19, 26.2% identity in 225 aa. Human DNA sequence from clone RP13-469L5 on chromosome X Contains the gene for KIAA0189 GP:AL360076_1 protein and a CpG island, complete C.RGFLSAGFYRAKNWAATSAGGSGA.N 2 2.612 0.100 G, P sequence; match: proteins: Tr:O14868 Tr:Q9R0Z9 Tr:Q63744 Tr:Q9Y3M8 Tr:Q92502 Tr:Q9VFK2. D.SLLDPLGLDPLPCLCPY.F 2 2.447 0.201 Mouse DNA sequence from clone RP23-106N23 on chromosome 1. Contains the gene for a novel protein kinase (ortholog of human dJ272L16.1 H.WKLASGLGCEPCACDPRNSLSSQCNQ GP:AL365314_2 3 4.013 0.136 A, O and rat Ca2+/calmodulin dependent FTGQCPCR.E protein kinase), the Lamb3 gene for laminin, beta 3, a putative novel gene, the ge Q.KYTELKDRLGQSPVLGEQGNR.I 2 2.787 0.092 GP:AL389891_3 Neurospora crassa DNA linkage group R.HADELEK.S 1 1.934 0.083 O Supplementary Table 1 118 I BAC clone B7F18; similarity to transcription factor TMF, TATA element modulatory factor, Homo sapiens, PIR:A47212. Thermoplasma acidophilum complete genome; segment 3/5; similarity to GP:AL445065_17 known protein: acylaminoacyl- I.YDPGKRQIGKITTDGKR.S 2 2.733 0.114 G peptidase (EC 3.4.19.1) - human; PIR1:JC4655. Thermoplasma acidophilum complete genome; segment 3/5; similarity to GP:AL445065_223 known protein: isoleucine--tRNA P.RCETSLSSHEVAQGYK.D 1 2.290 0.162 A, O ligase (EC 6.1.1.5) - human; PIR:I59314. V.IDTWFDSGSATYAASHYPFE.K 2 2.517 0.113 Thermoplasma acidophilum complete genome; segment 5/5; similarity to unknown protein: conserved hypothetical protein - Thermotoga GP:AL445067_117 H.MRGMHGGLSEKEMLIPLA.F 2 2.461 0.258 O, P maritima (strain MSB8); PIR:E72235. Relation: weak similarity to plasma- cell membrane glycoprotein pc-1 - human, SWISSPR V.KKEDLDDVVRYAKKE.F 1 2.038 0.113 Thermoplasma acidophilum complete genome; segment 5/5; similarity to GP:AL445067_70 R.SRVTLAQAEVEAAQK.M 1 2.347 0.092 P known protein: membrane protein 7, erythrocyte - human; PIR2:S17659. Human DNA sequence from clone RP11-74P14 on chromosome 1 Contains part of a novel gene, a novel gene, ESTs, STSs, GSSs and CpG IPI:IPI00045120.1 GP:AL445468_2 K.AIVSGPGKAIISSLGKAIVCSLGK.A 2 2.575 0.237 A, O islands, complete sequence; match: (98%) proteins: Tr:Q9RH86 Tr:O74423 Tr:O96449 Tr:Q25716 Tr:Q56193 Tr:Q16409 Tr:Q56192 Sw:O0283 V.SGLGKAIVSG.P 1 2.004 0.197 Homo sapiens (human) Human IPI:IPI00024284.2 GP:AL445795_1 Heparan Sulfate Proteoglycan A.LPQISMPQEVR.V 2 3.021 0.098 A, G, O, P (97%) (HSPG2) gene, exons 2 and 3. K.ELDGWVFVELDVGSEGNA.D 2 2.632 0.091 T.SLIVTIQGSGSSHVPSVSPPIRIESSSPT 3 3.905 0.100 VVEGQTLDL.N V.SPPIRIESSSPTVVEGQTLDL.N 2 2.533 0.152 Leishmania major Friedlin chromosome 21 cosmid L5174; L5174.04, len = 719 aa, unknown; some similarity to RINI_HUMAN, GP:AL445944_4 C.LLRDVQDGV.G 1 2.011 0.160 G placental ribonuclease inhibitor (460 aa, Homo sapiens, EMBL: M36717, AAA60249); Fasta scores: E():0.00039, 25.6% identity in 469 aa L.PTPEAAITVLQLCQNTSLLAS.L 2 2.734 0.196 S.ALAELVAAAPWTR.V 2 2.210 0.166 Leishmania major Friedlin chromosome 13 PAC P214; P214.44, len = 324 aa, unknown; predicted coiled-coil region at aa 124-134; GP:AL449144_41 G.YATCIRATEYPGLALCEYNA.V 2 2.483 0.156 O, P some similarity to Q9UGX1, dj402g11.7 (662 aa, Homo sapiens, EMBL: AL022328, CAB63049); Fasta scores: E():4.4, 24.6% ident S.PSGVLSLSR.A 1 1.884 0.152 Homo sapiens mRNA; cDNA DKFZp547K202 (from clone IPI:IPI00080585.2 GP:AL512685_1 G.RVGTHGGTLSSYIVKNIALDK.T 2 2.207 0.170 P DKFZp547K202); WD-protein The (98%) frame shift was determined manually. T.FDLEAMFEQTRR.T 2 2.227 0.161 Homo sapiens mRNA; cDNA DKFZp547B2013 (from clone GP:AL512730_1 K.SSSGVLLVSSPTMPHLGTMLSPA.S 2 2.450 0.146 G DKFZp547B2013); DNA-binding protein R kappa B (Homo sapiens). S.PGTSAPSASTAAVIQNVTGQNIIK.Q 2 2.238 0.112 Homo sapiens mRNA; cDNA GP:AL512758_1 G.PSPGAPGLPSPSVRAPLGHK.C 2 2.502 0.086 G DKFZp547D155 (from clone Supplementary Table 1 119 DKFZp547D155); unknown protein. Neurospora crassa DNA linkage group V BAC contig B11N2; similarity to GP:AL513444_1 V.PAKIRLTSEPSPINLNPPDFTALNR.K 3 3.768 0.128 G predicted rna binding protein, homo sapiens, TREMBL:AB016092_1. Neurospora crassa DNA linkage group V Cosmid contig 9G6; similarity to TRANSCRIPTION INITIATION FACTOR TFIID 100 KDA SUBUNIT, GP:AL513463_20 A.HNLDLDEIDQLEGIPG.V 2 2.555 0.202 G Homo sapiens, SWISSPROT:T2D4_HUMAN Contains Trp-Asp (WD-40) repeats signature [LVSGGLDGTVRLWDV]. L.SFSAESNVLVSGGLDGT.V 1 2.099 0.125 Neurospora crassa DNA linkage group V Cosmid contig 9G6; similarity to GP:AL513463_31 A.TSREQQSSSNSSEQKTE.L 2 2.647 0.086 P TGF beta receptor associated protein 1, Homo sapiens, PIR:T08622. Neurospora crassa DNA linkage group V BAC contig B18D24; similarity to GP:AL513466_12 protein phosphatase 2A B56-delta R.LEEVDGTEDNQKRL.D 1 2.013 0.151 G (PP2A), Homo sapiens, SWISSPROT:2A5D_HUMAN. Zebrafish DNA sequence from clone RP71-20I5 Contains a gene for a novel protein similar to human GP:AL590146_1 FLJ20730 protein, a gene for a novel K.PTKVRPTKKKNGDKDISNAYE.E 2 2.528 0.134 G, P protein similar to rat steroid sensitive gene-1 protein (SSG-1), a gene for a novel protein similar to vertebrate c R.STTTTTTTTTTTTRP.T 2 2.639 0.099 Arabidopsis thaliana DNA chromosome 5, BAC clone T2L20 (ESSA project); similarity to TETRATRICOPEPTIDE REPEAT GP:AL592312_17 P.DASFNSAPFPRSSSGLSKPR.F 2 2.239 0.151 G PROTEIN 2 , human, SWISSPROT:TTC2_HUMAN Contains dnaJ domains signatures and profile AA1108-1127. S.LLISTYSEKLLTMKGEALLML.E 2 2.733 0.118 Salmonella enterica serovar Typhi (Salmonella typhi) strain CT18, complete chromosome; segment 17/20; Similar to e.g. Homo sapiens A.GLDVFEQEPLSVDSPLLNMSNVVAVPH GP:AL627281_38 3 4.269 0.159 A glyoxylate reductase grhpR IGSATHE.T TR:Q9UBQ7 (EMBL:AF134895) (328 aa) fasta scores: E(): 0, 39.9% id in 296 aa and Hyphomicrobi E.NALIAAL.Q 1 2.157 0.155 Homo sapiens genomic DNA, chromosome 6p21.3, HLA Class I IPI:IPI00019316.1 GP:AP000504_9 A.LYTVLLIVLV.M 1 2.131 0.136 A, O region, section 3/20; Ly6 family (91%) member alternative name: NG33. L.IVLVMMSLVF.G 1 2.073 0.083 Oryza sativa genomic DNA, chromosome 1, clone:P0708G02; Similar to Caenorhabditis elegans GP:AP001539_7 S.AAKDIGIKTKTITDLVAKL.A 2 2.652 0.163 G, O chromosome V cosmid T10G3; Homo sapiens endosomal protein P162 (Z81118). T.EIEPLVLDAESISAESVQRVSEF.D 2 2.979 0.117 Sequence 3 from Patent WO0069913; P.KSSDKTHTCPPCPAPELLGGPSVFLFP IPI:IPI00152302.1 GP:AX050364_1 3 3.506 0.268 G Human Fc DNA sequence. PKPK.D (98%) Sequence 3 from Patent WO0149831; IPI:IPI00160428.1 GP:AX191445_1 R.QNLSGAAAGEALVGAAG.F 1 2.624 0.128 G human XT-II. (93%) Sequence 1 from Patent WO0151520; GP:AX195245_1 F.RGLHSLDRLLLHQNRVAHV.H 2 2.588 0.136 P Predicted human Nogo receptor gene. L.SALPTEALAPLR.A 1 1.891 0.080 Sequence 3 from Patent WO0168704; human breast cancer amplified G- GP:AX253148_1 I.LIFCILTLVGNTAIILLLVMDVR.L 2 3.228 0.266 P protein coupled receptor 2 (BCA- GPCR-2). Sequence 7 from Patent WO0168704; human breast cancer amplified G- GP:AX253152_1 L.HMGMVRHTNESNLAGFILLGFSD.Y 2 3.129 0.082 G protein coupled receptor 4 (BCA- GPCR-4). Supplementary Table 1 120 Homo sapiens isolate sy-3A/E6 immunoglobulin alpha heavy chain GP:AY003710_1 K.NSIYLQMN.S 1 2.564 0.165 G, O, P variable region mRNA, partial cds; VH3 family, 3-07/DP-54. K.NSIYLQMNSLR.V 1 2.914 0.193 2 3.728 1.000 R.VEDTAVYYCARSSM.G 2 3.010 0.090 Homo sapiens isolate sy-3A/12-F6 immunoglobulin alpha heavy chain GP:AY003712_1 N.WFDPWGQGTLVTVSSASPTSPK.V 2 5.528 0.479 O, P variable region mRNA, partial cds; VH3 family, 3-30/DP-49. S.NWFDPWGQGTLVTVSSASPTSPK.V 2 2.212 0.138 W.FDPWGQGTLVTVSSASPTSPK.V 2 5.642 0.349 Homo sapiens isolate sy-3A/12-H9 immunoglobulin alpha heavy chain IPI:IPI00182107.1 GP:AY003714_1 K.XDGSEKYYVDSVK.G 2 2.967 0.253 O, P variable region mRNA, partial cds; (91%) VH3 family, 3-07/DP-54. Homo sapiens isolate sy-3A/1-D3 immunoglobulin alpha heavy chain GP:AY003716_1 D.YDFDYWGQGTLVTVSSASPTSPK.G 2 3.056 0.303 P variable region mRNA, partial cds; VH3 family, 3-21/DP-77. Homo sapiens isolate sy-3A/11-E8 immunoglobulin alpha heavy chain GP:AY003718_1 D.LWGRGTLVTVSSASPTSPK.V 2 2.623 0.260 O variable region mRNA, partial cds; VH3 family, 3-09/DP-31. Homo sapiens isolate sy-3A/5-G12 immunoglobulin alpha heavy chain GP:AY003719_1 D.GNTQYADSVK.G 2 2.847 0.088 O, P variable region mRNA, partial cds; VH3 family, 3-23/DP-47. H.FDRWGQGTLVTVSSASPTSPK.V 2 3.600 0.238 Homo sapiens isolate sy-3A/11-H6 immunoglobulin alpha heavy chain GP:AY003724_1 Q.GAMVTVSSASPTSPK.G 2 4.409 0.313 A, G, O, P variable region mRNA, partial cds; VH3 family, 3-23/DP-47. Homo sapiens isolate sy-3A/11-C10 immunoglobulin alpha heavy chain GP:AY003727_1 L.VNVSSASPTSPK.V 2 3.056 0.151 G, O, P variable region mRNA, partial cds; VH3 family, 3-15/DP-38. N.IDGGTTDYAAPVK.G 2 2.237 0.207 Homo sapiens isolate sy-3A/12-G1 immunoglobulin alpha heavy chain GP:AY003735_1 K.PGSLDYCGQGTLVTVSSASPTSPK.G 2 4.518 0.313 O, P variable region mRNA, partial cds; VH3 family, 3-30.5/DP-49. Homo sapiens isolate sy-1A/1-C1 immunoglobulin alpha heavy chain GP:AY003741_1 A.LNIWGQGTLVTVSSASPTSPK.V 2 3.420 0.310 G, P variable region mRNA, partial cds; VH1 family, 1-69/DP-10. R.SEDTAVYYCATRF.R 2 2.771 0.097 Homo sapiens isolate sy-1A/11-F3 immunoglobulin alpha heavy chain IPI:IPI00217045.1 GP:AY003745_1 P.LITAAIRDPWGQGTLVTVSSASPTSPK.- 2 2.791 0.210 O variable region mRNA, partial cds; (95%) VH1 family, 1-46/DP-7. Homo sapiens isolate sy-4A/11-H6 immunoglobulin alpha heavy chain GP:AY003755_1 L.VAVSSASPTSPK.V 2 2.824 0.250 P variable region mRNA, partial cds; VH4 family, 4-39/DP-79. Homo sapiens isolate sy-3A/17-C2 immunoglobulin alpha heavy chain GP:AY003761_1 S.GSGSNTYYADSVK.G 1 2.141 0.190 G variable region mRNA, partial cds; VH3 family, 3-23/DP-47. 2 2.696 0.098 Homo sapiens isolate sy-3A/17-G9 immunoglobulin alpha heavy chain GP:AY003763_1 K.GLEWVAFLR.K 1 1.935 0.114 G variable region mRNA, partial cds; VH3 family, 3-30/cos-3. 2 3.282 0.276 K.NTLYLQMDGLR.A 2 3.251 0.107 Homo sapiens isolate sy-4M/7-H8 immunoglobulin mu heavy chain GP:AY003788_1 E.IDHSGSTNYNPSLK.S 2 2.948 0.196 G variable region mRNA, partial cds; VH4 family, 4-59/DP-71. Homo sapiens isolate sy-5M/5-F1 immunoglobulin heavy chain variable GP:AY003816_1 K.GLEWMGIIYPGDSDTK.Y 2 2.598 0.275 G region mRNA, partial cds; 5-51/COS- 25. Supplementary Table 1 121 Mus musculus PRAME-like 3 (Pramel3) mRNA, complete cds; GP:AY004873_1 similar to Homo sapiens PRAME; L.LDLATQSLLSNEHAA.I 2 2.526 0.154 A, G preferentially expressed antigen in melanoma. L.RQDAGCKTVCPEIS.T 2 2.543 0.121 Homo sapiens clone Vb9con14 T cell receptor beta chain mRNA, partial GP:AY006200_1 Y.FCASSQLAAPNT.G 2 2.719 0.144 P cds; CDR3 region; consists of 3'V- beta, Db, and 5'J-beta. Synthetic construct clone E10 anti- human C3a receptor single-chain GP:AY008748_1 G.TNVAWYQQK.P 1 2.060 0.109 G variable fragment antibody light chain mRNA, partial cds. Homo sapiens FYVE-finger-containing GP:AY009133_1 Rab5 effector protein Rabenosyn-5 D.IVKLYEKLR.L 2 2.726 0.106 O mRNA, complete cds. Homo sapiens type V preprocollagen alpha 2 chain (COL5A2) gene, exons GP:AY016295_1 34 through 52 and partial cds; and G.TPGKVGPTGATGDK.G 1 1.992 0.168 G, P type III preprocollagen alpha 1 chain (COL3A1) gene, exons 2 through 52. R.GNPGSRGENGPTGAVGFAGPQGPDG 2 2.456 0.232 QPGV.K Homo sapiens NYD-SP16 mRNA, S.LFEIISFPAKTALTSIIYASYAALIYLAVCV IPI:IPI00167895.1 GP:AY027526_1 3 3.804 0.121 O complete cds. NAVLK.K (94%) Homo sapiens brother of CDO (BOC) IPI:IPI00018701.1 GP:AY027658_1 mRNA, complete cds; member of Ig R.PSITPRLWQDAELATGTPPVSPSK.L 2 2.900 0.095 G (94%) superfamily. Homo sapiens ATP-binding cassette IPI:IPI00103486.1 GP:AY028900_1 E.EKLVYSLPLEK.T 2 3.612 0.142 A, G, O A10 mRNA, complete cds; ABC-A10. (97%) E.KLVYSLPLEK.T 1 2.317 0.080 L.MTVMGLRESAFWLSWXLT.Y 2 2.489 0.123 R.NYAVSVTSLNEVFLNL.E 1 2.574 0.095 Homo sapiens myo-inositol IPI:IPI00015834.1 GP:AY032885_1 monophosphatase A3 (IMPA3) L.GGEPGGGAAGPAAAAD.G 1 2.632 0.248 O, P (91%) mRNA, complete cds. Homo sapiens clone case2-03 GP:AY033253_1 immunoglobulin heavy chain variable R.LTIDPDTSK.N 1 2.297 0.164 G region mRNA, partial cds; IGHV. Homo sapiens clone case2-20 GP:AY033270_1 immunoglobulin heavy chain variable -.EVQLVESGGGLVQPGESLR.L 2 5.026 0.396 G, O, P region mRNA, partial cds; IGHV. Homo sapiens clone case3-02 IPI:IPI00217045.1 GP:AY033272_1 immunoglobulin heavy chain variable M.GIINPSGVSTSYAQK.F 2 2.674 0.202 G (97%) region mRNA, partial cds; IGHV. Homo sapiens clone case3-10 IPI:IPI00009792.1 GP:AY033280_1 immunoglobulin heavy chain variable R.INPDSGGTDYAQK.F 2 2.844 0.292 G, O, P (91%) region mRNA, partial cds; IGHV. Homo sapiens clone case3-14 GP:AY033284_1 immunoglobulin heavy chain variable -.EVQLVQSGPEVR.K 2 3.116 0.290 O region mRNA, partial cds; IGHV. Homo sapiens clone case3-18 IPI:IPI00018563.3 GP:AY033288_1 immunoglobulin heavy chain variable K.GLEWMGIIYPGDSDAR.Y 2 3.508 0.387 G (96%) region mRNA, partial cds; IGHV. M.GIIYPGDSDAR.Y 2 2.360 0.242 Homo sapiens apoptosis regulator BCL-G median form (BCLG) mRNA, IPI:IPI00045049.1 GP:AY040274_1 L.EEIPLDDDDLNTIEFK.I 1 2.688 0.110 G complete cds; member of the BCL-2 (95%) family. Homo sapiens MHC class I antigen GP:AY040668_1 (HLA-B) mRNA, HLA-B*73 new allele, R.FITVGYVDDTQFVRFDRDAAS.P 2 3.138 0.211 A partial cds. Homo sapiens IgA6 immunoglobulin GP:AY044149_1 heavy chain variable region mRNA, L.VQFGEGLVQPGGSLR.L 2 3.244 0.165 G, P partial cds; immunoglobulin VH. Q.VQLVQFGEGLVQPGGSLR.L 2 4.357 0.085 Homo sapiens 5-kappa immunoglobulin light chain variable GP:AY044152_1 -.APELTQSPGTLSLSPGER.A 2 2.549 0.085 P region mRNA, partial cds; immunoglobulin Vkappa. Homo sapiens heart alpha-kinase IPI:IPI00179569.1 GP:AY044450_1 (HAK) mRNA, complete cds; E.IEFSQL.I 1 2.177 0.095 G (96%) expressed predominantly in heart. Homo sapiens dynein heavy chain IPI:IPI00163906.1 GP:AY049075_1 D.EPLFLSLIENLFPNILLDK.A 2 3.346 0.112 P (DNAH5) mRNA, partial cds. (98%) Supplementary Table 1 122 Homo sapiens clone WR10 GP:AY050690_1 immunoglobulin heavy chain variable R.QAPGQGLEWMGGV.I 2 2.908 0.153 G region mRNA, partial cds. Homo sapiens clone WR13 GP:AY050694_1 immunoglobulin heavy chain variable R.QAPGQGLEWMGGIIPIFNA.A 2 2.658 0.215 G region mRNA, partial cds. R.QAPGQGLEWMGGIIPIFNAAT.Y 2 3.311 0.374 Homo sapiens clone WR1VL GP:AY050703_1 immunoglobulin light chain variable -.EFVLTQSPSTLSASVGDR.V 2 6.075 0.117 G, O, P region mRNA, partial cds. Homo sapiens clone WR3VL GP:AY050707_1 immunoglobulin light chain variable R.NDLGWYQQEPGK.A 2 3.786 0.175 G, O region mRNA, partial cds. Homo sapiens clone WR8VL IPI:IPI00026197.1 GP:AY050710_1 immunoglobulin light chain variable N.LNYLAWYQQKPGQPPK.L 2 2.761 0.303 G (95%) region mRNA, partial cds. Homo sapiens cryopyrin (CIAS1) gene, exon 9 and complete cds, alternatively spliced; alternatively IPI:IPI00219193.1 GP:AY051117_2 K.HLLCNLKKLWLVNSGLTSVC.C 2 3.688 0.146 O spliced; corresponds to mRNA (94%) deposited in GenBank Accession Number AF427617. Homo sapiens 4-1BB-mediated IPI:IPI00167013.1 GP:AY052405_1 signaling molecule mRNA, complete P.VRAFLLISTLKDK.R 2 2.657 0.183 P (97%) cds; 4-1BBlrr; LRR-1 signaling protein. Arabidopsis thaliana unknown protein (T23K8.13) mRNA, complete cds; GP:AY056181_1 T.VFQPLLKDTLVAKGIVLNF.V 2 2.635 0.209 G contains similarity to gb|D13630 KIAA0005 gene from Homo sapiens. Homo sapiens nesprin-1 beta mRNA, IPI:IPI00024191.1 GP:AY061755_1 complete cds; nuclear envelope Q.DCNDLLKGLGTVKDSLF.V 1 2.450 0.226 A (91%) spectrin-repeat containing protein. Homo sapiens, Similar to Nedd-4-like ubiquitin-protein ligase, clone IPI:IPI00013010.1 GP:BC000108_1 G.KRIGSSELLWNEI.I 2 2.458 0.197 P MGC:2079 IMAGE:3508225, mRNA, (91%) complete cds. L.KVWSCHTLRNELLGTASVNLSNVLK.N 2 2.349 0.124 Homo sapiens, clone MGC:3103 GP:BC000207_1 IMAGE:3350518, mRNA, complete P.GPSDIAASARTAA.E 1 2.302 0.113 G cds. Homo sapiens, phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness IPI:IPI00216751.1 GP:BC000249_1 E.KEEEERVAAKKGTEICNGGPAPK.S 2 2.627 0.107 O 3, autosomal dominant), clone (96%) MGC:1689 IMAGE:3356353, mRNA, complete cds. Homo sapiens, Similar to clones 23667 and 23775 zinc finger protein, IPI:IPI00106475.1 GP:BC000330_1 V.QNTSIPLGQGLVE.S 2 2.743 0.117 G clone MGC:8520 IMAGE:2822464, (91%) mRNA, complete cds. Homo sapiens, clone MGC:8675 GP:BC000424_1 IMAGE:2964526, mRNA, complete D.FPTENPNDNSVLGNL.R 1 2.928 0.095 P cds. Homo sapiens, Similar to serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment R.SSTSPTTNVLLSPLSVATALSALSLGAE IPI:IPI00006114.2 GP:BC000522_1 2 4.162 0.453 O, P epithelium derived factor). member 1, QR.T (91%) clone MGC:8593 IMAGE:2961120, mRNA, complete cds. 3 5.393 0.397 Homo sapiens, Similar to hypothetical protein, clone MGC:2690 IPI:IPI00154833.1 GP:BC000757_1 R.GADLYGQKNSATQEE.L 2 3.021 0.125 O IMAGE:2820364, mRNA, complete (95%) cds. Homo sapiens, Similar to hypothetical protein 628, clone MGC:5116 IPI:IPI00021329.1 GP:BC000974_1 R.DRIVVVLDSMIKVFTF.T 2 2.787 0.110 P IMAGE:3450672, mRNA, complete (93%) cds. Homo sapiens, clone MGC:2376 GP:BC001062_1 IMAGE:2819500, mRNA, complete K.QFLLQVPGYSENLELMVRLARA.E 3 4.266 0.163 O, P cds. Homo sapiens, U3 snoRNP- associated 55-kDa protein, clone GP:BC001113_1 A.AARKRGKPASGAGAGAGAGKRR.R 2 2.872 0.143 O MGC:1474 IMAGE:3050186, mRNA, complete cds. Homo sapiens, Similar to GP:BC001121_1 K.SWKLAGYDVPGASTMVLHIP.D 2 2.758 0.125 P deoxyguanosine kinase, clone Supplementary Table 1 123 MGC:2111 IMAGE:2989352, mRNA, complete cds. Homo sapiens, clone MGC:3169 GP:BC001195_1 IMAGE:3355479, mRNA, complete F.FCPLDLFYKCVCFLPVKLI.F 2 2.896 0.120 O cds. H.HHDNHGGSHSGGGPGAQHSAMPA.K 2 3.241 0.196 Homo sapiens, kinesin family member C3, clone MGC:3226 IPI:IPI00216849.1 GP:BC001211_1 S.SGTSSRPGSIRRKLQPSGK.S 1 2.209 0.163 P IMAGE:3503847, mRNA, complete (97%) cds. Homo sapiens, clone MGC:5297 IPI:IPI00000650.1 GP:BC001295_1 IMAGE:3453776, mRNA, complete R.LRKGGMEVRNL.C 1 1.805 0.115 A (98%) cds. Homo sapiens, hypothetical protein FLJ13390 similar to PAF53, clone IPI:IPI00102091.1 GP:BC001337_1 E.DHKLGTLSLPLPPAQTSDRLA.K 2 2.407 0.132 A, O MGC:5609 IMAGE:3461710, mRNA, (99%) complete cds. L.YLPPCYDDAAK.P 1 1.821 0.188 Homo sapiens, solute carrier family 9 (sodium/hydrogen exchanger), isoform N.EPREADKSHPEQRELRPRLCTMKKGP GP:BC001443_1 3 regulatory factor 1, clone MGC:1482 3 3.981 0.120 A SGY.G IMAGE:3138881, mRNA, complete cds. Homo sapiens, clone GP:BC001673_1 E.KKLRRIKGLNQEVTSKDMLRTL.A 2 2.763 0.125 A IMAGE:2823236, mRNA, partial cds. Homo sapiens, hypothetical protein FLJ22405, clone MGC:2543 IPI:IPI00103891.1 GP:BC001674_1 P.AGAPTQAAWLAALSDR.E 2 2.316 0.201 A, G IMAGE:2961594, mRNA, complete (95%) cds. V.EDVTEEDC.A 1 2.155 0.091 Homo sapiens, Similar to translocase of outer mitochondrial membrane 34, IPI:IPI00009946.2 GP:BC001763_1 I.KDCTSALALVPF.S 1 2.345 0.100 A clone MGC:1252 IMAGE:3544124, (96%) mRNA, complete cds. Homo sapiens, Similar to KIAA0005 gene product, clone MGC:769 IPI:IPI00186440.1 GP:BC001804_1 G.KSVFLEQMKKFVEWL.K 1 2.088 0.089 G, P IMAGE:3354883, mRNA, complete (96%) cds. K.DIILYVKE.E 1 2.014 0.115 Homo sapiens, RAD54, S. cerevisiae, homolog of, B, clone MGC:4982 IPI:IPI00018281.1 GP:BC001965_1 I.FTVDQDHKVEE.F 2 2.743 0.140 A IMAGE:3452509, mRNA, complete (99%) cds. R.PHQKEGIIFLYECVMGMRMNGRCGAIL 3 3.674 0.194 ADE.M Homo sapiens, clone MGC:5306 GP:BC001972_1 IMAGE:3460203, mRNA, complete I.EKLKYEHHLKE.S 2 3.172 0.128 O cds. Homo sapiens, clone GP:BC001974_1 S.LQSSPSPGAQPR.V 1 1.916 0.081 O IMAGE:3457069, mRNA, partial cds. Homo sapiens, clone MGC:1203 IPI:IPI00013273.1 GP:BC002462_1 IMAGE:3344738, mRNA, complete H.SFLTEVTDVYEMEGGLLNL.L 2 3.237 0.167 G, O (91%) cds. Homo sapiens, Similar to hypothetical protein FLJ10709, clone MGC:941 IPI:IPI00004160.1 GP:BC002542_1 K.LARQRYEDQLKQQRL.L 1 1.856 0.085 G IMAGE:3138578, mRNA, complete (97%) cds. Homo sapiens, clone MGC:4161 GP:BC002636_1 IMAGE:3606994, mRNA, complete R.GDALNLSSPKRSKPDAS.S 1 1.839 0.117 A cds. Homo sapiens, clone IPI:IPI00178047.1 GP:BC002875_1 V.IVPEGLPPLPPPPPSGATPP.P 2 3.249 0.096 A IMAGE:3940843, mRNA, partial cds. (99%) Homo sapiens, HSCARG protein, GP:BC002927_1 clone MGC:11351 IMAGE:3954035, L.TKHTRKVVHDAK.M 1 2.194 0.088 G mRNA, complete cds. Homo sapiens, Similar to expressed P.RKREAGEAGAATSKQRVLDEEEYIEGL GP:BC003015_1 sequence 2 embryonic lethal, clone 3 3.617 0.188 G QTVIQR.D IMAGE:2821316, mRNA, partial cds. Homo sapiens, Similar to steroidogenic acute regulatory protein GP:BC003074_1 related, clone MGC:3251 D.ASERAALIPGGLSDGQFY.S 2 3.336 0.167 O IMAGE:3505985, mRNA, complete cds. Homo sapiens, clone IPI:IPI00217543.1 GP:BC003123_1 H.PLVEVQRKDTSAILDMK.W 2 2.905 0.082 P IMAGE:3502107, mRNA, partial cds. (99%) GP:BC003576_1 Homo sapiens, actinin, alpha 1, clone D.QVMASFKILAGDK.N 2 2.651 0.132 G, O IPI:IPI00025845.1 Supplementary Table 1 124 MGC:2358 IMAGE:3547017, mRNA, (99%) complete cds. E.EHARQQHNERLRKQFGAQA.N 2 2.743 0.132 Homo sapiens, Similar to RIKEN GP:BC003598_1 cDNA 1300006O23 gene, clone D.DIESETGSTGALETRSLK.D 2 3.554 0.116 P IMAGE:3537458, mRNA, partial cds. Homo sapiens, clone MGC:10772 GP:BC004261_1 IMAGE:3606982, mRNA, complete A.HPHPHHHALPHPPPTHLSVPPR.P 2 2.242 0.121 A, O cds. L.SRRDSAEKQEQPPPSYK.P 2 2.296 0.108 Homo sapiens, hypothetical protein FLJ23239, clone MGC:10839 GP:BC004278_1 R.REGCWGLHTCLITAARLRQSGWE.H 2 2.638 0.232 P IMAGE:3615986, mRNA, complete cds. Homo sapiens, clone MGC:10902 GP:BC004304_1 IMAGE:3625247, mRNA, complete A.FSNASRGFQNPETLADIPAS.P 2 2.702 0.130 A cds. Homo sapiens, hypothetical protein FLJ11979, clone MGC:4314 IPI:IPI00154852.1 GP:BC004457_1 A.CAGGFVDIVKVLLNEGANIE.D 2 2.792 0.190 G IMAGE:2819955, mRNA, complete (96%) cds. Homo sapiens, Similar to RIKEN GP:BC004493_1 cDNA 1110014F24 gene, clone Y.FSRLWEDFK.Q 1 3.046 0.111 A, O IMAGE:3690018, mRNA, partial cds. Homo sapiens, cleft lip and palate associated transmembrane protein 1, GP:BC004865_1 K.TKNLLTGETEADPEM.I 2 2.619 0.207 O clone MGC:10593 IMAGE:3840991, mRNA, complete cds. Homo sapiens, clone GP:BC004874_1 L.FSYFDAGAAGAGPRSLSS.D 1 2.394 0.410 G IMAGE:3687515, mRNA, partial cds. Homo sapiens, MUF1 protein, clone GP:BC004953_1 MGC:10893 IMAGE:3622774, mRNA, D.FVFIVAGEKEDGEEMEIGEV.A 3 4.080 0.145 A, O, P complete cds. L.PILELTR.A 1 1.825 0.109 Homo sapiens, Similar to membrane bound C2 domain containing protein, GP:BC004998_1 G.EALAVLTSFGRRLLVLIPVYLAGAVGL.S 3 4.780 0.093 P clone MGC:4422 IMAGE:2958094, mRNA, complete cds. Homo sapiens, Similar to E2F IPI:IPI00005630.1 GP:BC005098_1 transcription factor 1, clone R.PVMLPVSPEPLLSRMGSLRAPVDE.D 2 2.578 0.299 O (91%) IMAGE:3510651, mRNA, partial cds. Homo sapiens, Similar to RIKEN cDNA 3010001K23 gene, clone IPI:IPI00031572.1 GP:BC005158_1 L.YPCASLLAFASTCLLSRFSVGI.F 2 3.053 0.101 A MGC:4618 IMAGE:3505819, mRNA, (95%) complete cds. Homo sapiens, uncharacterized hematopoietic stem/progenitor cells GP:BC005336_1 protein MDS031, clone MGC:12423 K.FSAFLDK.V 1 2.019 0.100 G IMAGE:3996922, mRNA, complete cds. Homo sapiens, clone MGC:12466 GP:BC005360_1 IMAGE:3684736, mRNA, complete E.DQNIQDDFKNPGRNLSSHVVERLF.E 3 4.536 0.102 O, P cds. Homo sapiens, Similar to RIKEN cDNA 1810009K13 gene, clone IPI:IPI00218597.1 GP:BC005835_1 T.RHYAQAYYGWSLRHA.T 2 3.076 0.137 P MGC:2408 IMAGE:2822632, mRNA, (99%) complete cds. Homo sapiens, clone MGC:14588 IPI:IPI00178429.1 GP:BC005951_1 IMAGE:4249174, mRNA, complete C.MVGHEALPLAFTQE.T 2 3.295 0.457 P (91%) cds. K.KGDTFSCMVGHEALPLAFTQE.T 3 4.317 0.149 M.DVWGKGTTVTVSSASPTSPK.V 2 2.260 0.198 M.VGHEALPLAFTQE.T 2 3.635 0.259 Homo sapiens, Similar to RIKEN cDNA 1300003A17 gene, clone IPI:IPI00171014.1 GP:BC006108_1 T.ETLSKYDTVLKDEEPGDGLYGW.T 2 3.296 0.180 A MGC:12961 IMAGE:3029084, mRNA, (92%) complete cds. Homo sapiens, clone GP:BC006126_1 G.ESPAGSATYR.E 1 1.800 0.106 O, P IMAGE:3603998, mRNA, partial cds. L.DTPTPMVPTSRVPGTLAPVAT.S 2 2.777 0.087 Homo sapiens, RaP2 interacting protein 8, clone MGC:1161 IPI:IPI00179304.1 GP:BC006194_1 A.PLAQGSK.E 1 1.806 0.097 A, G, O IMAGE:2823366, mRNA, complete (92%) cds. D.YTPYLKF.T 1 2.279 0.080
Supplementary Table 1 125 Homo sapiens, ventral anterior homeobox 2, clone MGC:12577 GP:BC006336_1 G.EADHCRRILVRDAK.G 1 2.040 0.148 G, P IMAGE:4304066, mRNA, complete cds. Q.RCQYVVGR.E 1 1.867 0.125 Homo sapiens, Similar to immunoglobulin heavy constant GP:BC006402_1 gamma 3 (G3m marker), clone S.LGFDYWGQGTLVTVSSASTK.G 2 2.721 0.123 G MGC:12848 IMAGE:4308411, mRNA, complete cds. Homo sapiens, clone MGC:13105 GP:BC006436_1 IMAGE:3957973, mRNA, complete C.ECNQCEKAFRKPSIF.T 1 2.169 0.135 G cds. Homo sapiens, hypothetical protein FLJ10535, clone MGC:953 GP:BC006525_1 K.KNEELEQLYQDQE.V 1 2.870 0.080 A IMAGE:2966366, mRNA, complete cds. Homo sapiens, serum amyloid A1, IPI:IPI00022368.1 GP:BC007022_1 clone MGC:12369 IMAGE:4071612, F.FSFLGEAFDGAR.D 2 3.431 0.392 A, O, P (99%) mRNA, complete cds. F.SFLGEAFDGAR.D 2 2.547 0.280 G.NYDAAKR.G 2 2.393 0.219 K.RGPGGVWAAEAISDAR.E 2 3.707 0.318 3 4.240 0.318 R.EANYIGSDKYFHAR.G 2 3.435 0.455 R.FFGHGAEDSLADQAADEWG.R 2 3.123 0.292 R.FFGHGAEDSLADQAADEWGR.S 2 6.601 0.387 3 5.763 0.383 R.GNYDAAKR.G 2 2.433 0.252 R.GPGGVWAAE.A 1 1.909 0.183 R.SFFSFLGEAFDGAR.D 2 4.915 0.406 R.SGKDPNHFRPAGLPEK.Y 2 3.095 0.309 R.SGKDPNHFRPAGLPEKY.- 2 3.735 0.348 S.FFSFLGEAFDGAR.D 2 4.089 0.408 Homo sapiens, clone MGC:12455 IPI:IPI00004639.2 GP:BC007047_1 IMAGE:4071810, mRNA, complete D.YTLKIDLADFEKNSRYA.Q 3 3.834 0.101 A (95%) cds. Homo sapiens, carboxypeptidase B2 (plasma), clone MGC:12495 IPI:IPI00019131.1 GP:BC007057_1 R.LVDFYVMPVVNVDGYDYSWK.K 2 3.599 0.400 P IMAGE:3934520, mRNA, complete (98%) cds. Homo sapiens, hypothetical protein FLJ10305, clone MGC:14930 IPI:IPI00011956.1 GP:BC007214_1 L.PYSSGILTAVLPCLA.Y 2 2.897 0.199 G IMAGE:2819370, mRNA, complete (99%) cds. Homo sapiens, I-kappa-B-interacting Ras-like protein 2, clone MGC:4553 IPI:IPI00021124.1 GP:BC007450_1 A.QHWAKSEKVK.L 1 2.333 0.149 G IMAGE:3028708, mRNA, complete (92%) cds. 2 2.720 0.165 Homo sapiens, clone MGC:15483 GP:BC007558_1 IMAGE:2987974, mRNA, complete P.GLRDSCASASQIGGTTGV.C 2 2.886 0.115 O cds. Homo sapiens, Similar to RIKEN GP:BC007575_1 cDNA 1200014H14 gene, clone P.GRPACPLSNLLLQSYEER.E 2 3.403 0.096 P IMAGE:3139657, mRNA, partial cds. Homo sapiens, Similar to RIKEN IPI:IPI00063544.1 GP:BC007644_1 cDNA 9430029K10 gene, clone L.VTVNTDLTTIDLVAFLGYKYVGM.I 3 4.345 0.103 P (92%) IMAGE:3534558, mRNA, partial cds. Homo sapiens, hepatocellular carcinoma-associated antigen 59, IPI:IPI00180248.1 GP:BC007664_1 R.VGDTEKPEPER.S 1 2.059 0.109 G clone MGC:866 IMAGE:3140172, (96%) mRNA, complete cds. Homo sapiens, Similar to RIKEN cDNA 1190008H24 gene, clone IPI:IPI00172479.1 GP:BC007734_1 V.VFTSSGGETLWNLPAIKSMCN.V 2 3.128 0.137 A MGC:13130 IMAGE:4123247, mRNA, (98%) complete cds. Homo sapiens, clone MGC:12849 GP:BC007782_1 IMAGE:4308973, mRNA, complete S.YVLTQPASVSVAPGQTAR.I 2 3.887 0.319 G, O, P cds. Homo sapiens, clone MGC:5406 GP:BC008207_1 IMAGE:3447276, mRNA, complete A.KQRKKSQIQGRKKLKSEFNEP.G 2 2.578 0.117 O, P cds.
Supplementary Table 1 126 A.RAPDSLETSDSDSDSDSETDSDSS.S 2 2.599 0.127 Homo sapiens, clone GP:BC008345_1 A.SENLRQELTSQAERAEEL.G 2 3.255 0.213 A IMAGE:3531356, mRNA, partial cds. Homo sapiens, clone MGC:17331 IPI:IPI00063093.1 GP:BC008604_1 IMAGE:4180869, mRNA, complete I.HVTLTEKELQELTKPK.E 2 2.910 0.169 A, G, P (97%) cds. I.HVTLTEKELQELTKPKESSRET.T 3 3.796 0.136 L.ALDGESTMGHR.K 2 2.315 0.152 Homo sapiens, Similar to acyl- Coenzyme A oxidase 1, palmitoyl, IPI:IPI00014285.2 GP:BC008767_1 V.HRGRPEPLDLHLGMFLPTLLHQATA.E 2 2.988 0.169 P clone MGC:1198 IMAGE:3051501, (95%) mRNA, complete cds. Homo sapiens, nuclear factor of kappa light polypeptide gene enhancer in B- GP:BC008782_1 cells inhibitor-like 2, clone MGC:3398 H.VRVSPGQAAPAMARPRRSRHGPA.S 2 2.415 0.202 A IMAGE:3628374, mRNA, complete cds. V.SEPSGDSSAAGQPLGPAP.P 1 2.094 0.103 Homo sapiens, clone MGC:17332 GP:BC009037_1 IMAGE:4182164, mRNA, complete F.EAEVLHTVLAGRLLPPGAV.V 2 2.761 0.104 G cds. Homo sapiens, clone GP:BC009067_1 L.VALLVETQM.K 1 2.139 0.121 A, O IMAGE:3854442, mRNA, partial cds. Homo sapiens, clone GP:BC009115_1 N.YLTVIGYPNAEFK.S 1 2.329 0.118 P IMAGE:4154008, mRNA, partial cds. Homo sapiens, hypothetical protein FLJ23323, clone MGC:14873 IPI:IPI00002902.1 GP:BC009257_1 K.ILRDLSILSYLSQLQPPMPK.P 2 2.589 0.097 A, G IMAGE:3948222, mRNA, complete (91%) cds. N.YENYIDI.V 1 2.309 0.088 Homo sapiens, clone MGC:16638 IPI:IPI00181662.1 GP:BC009373_1 IMAGE:4121964, mRNA, complete F.KSITHSFKVQTLARSLGLQMP.V 2 2.701 0.089 G (99%) cds. Homo sapiens, Similar to HSPC156 protein, clone MGC:16478 IPI:IPI00163647.1 GP:BC009499_1 F.DLLFENAFDQWVASTASEKC.T 2 3.441 0.134 O IMAGE:3955370, mRNA, complete (95%) cds. Homo sapiens, clone GP:BC009558_1 A.GPPVYNPAAPPPYMPPQPSY.P 2 3.190 0.101 P IMAGE:3899550, mRNA, partial cds. Homo sapiens, Similar to RIKEN cDNA 2010005E21 gene, clone GP:BC009613_1 E.LSNLLK.L 1 1.803 1.000 P MGC:14816 IMAGE:4245944, mRNA, complete cds. Homo sapiens, hypothetical protein FLJ20671, clone MGC:4950 GP:BC009645_1 R.FLEDLVAKAVPEKLQPLLDSLE.Q 2 2.925 0.117 G IMAGE:3458006, mRNA, complete cds. Homo sapiens, hypothetical protein FLJ12089, clone MGC:15046 GP:BC009828_1 D.LLAALPLALVLLA.M 1 2.592 0.149 P IMAGE:3936998, mRNA, complete cds. Homo sapiens, clone MGC:2033 GP:BC009896_1 IMAGE:3504952, mRNA, complete R.RSDSVSASERAGPS.R 2 2.607 0.123 P cds. Homo sapiens, Similar to RIKEN GP:BC009977_1 cDNA 2410127E18 gene, clone Q.LLHLGLTQGL.I 1 2.213 0.162 A IMAGE:4122193, mRNA, partial cds. Homo sapiens, clone MGC:17508 IPI:IPI00186382.1 GP:BC010231_1 IMAGE:3455740, mRNA, complete A.IRRDPEACEKLEATMLRLR.R 2 3.111 0.164 G, O, P (98%) cds. Homo sapiens, clone MGC:14993 IPI:IPI00184353.1 GP:BC010420_1 IMAGE:3613406, mRNA, complete K.KFHVGHLRSTIIGNFIANLKEALGHQ.V 3 3.962 0.101 A, O (95%) cds. Homo sapiens, clone MGC:8880 IPI:IPI00179085.1 GP:BC010632_1 IMAGE:3873141, mRNA, complete S.FQISIGISSKSFK.D 2 2.855 0.081 A (94%) cds. Homo sapiens, clone GP:BC010663_1 A.DVQAAFSTIVSR.I 2 2.555 0.200 P IMAGE:3869770, mRNA, partial cds. Homo sapiens, Similar to hypothetical IPI:IPI00185975.1 GP:BC010682_1 protein FLJ20647, clone D.LEKYNQLKDAIAQAEMDLK.R 2 2.794 0.115 O (91%) IMAGE:3866821, mRNA, partial cds. Homo sapiens, Similar to Circadian GP:BC010706_1 Oscillatory Protein (SCOP), clone K.CQTVLCRNGK.P 2 2.697 0.082 O IMAGE:3874711, mRNA, partial cds. Homo sapiens, clone IPI:IPI00061988.1 GP:BC011001_1 V.IPLQYRQAGPVIAVQVENE.Y 2 2.704 0.108 G IMAGE:3938286, mRNA, partial cds. (91%) Supplementary Table 1 127 Homo sapiens, clone MGC:9335 IPI:IPI00178781.1 GP:BC011264_1 IMAGE:3451006, mRNA, complete I.RSAELQEKMAYLD.Q 2 2.763 0.090 O (98%) cds. Homo sapiens, Similar to interleukin 17 receptor, clone MGC:10262 IPI:IPI00217706.1 GP:BC011624_1 A.KWQALLGRGAPVRLRCDHGK.P 2 2.204 0.209 A IMAGE:4053746, mRNA, complete (93%) cds. G.LPVADLIPPPLKPRK.V 2 2.744 0.172 Homo sapiens, hypothetical protein FLJ20085, clone MGC:19816 GP:BC011684_1 I.MCENCMTTNQKKALKV.E 1 2.413 0.181 A IMAGE:3953055, mRNA, complete cds. Homo sapiens, Similar to calpain 4, small subunit (30K), clone I.SGAGGGGGGGGGGGGGGGGGGGGT. GP:BC011903_1 2 2.908 0.159 G MGC:20290 IMAGE:4120579, mRNA, A complete cds. Homo sapiens, Similar to RIKEN cDNA 0610010D20 gene, clone K.LGTFPFRGAVGGVCALANVLGAQVCQ IPI:IPI00167704.1 GP:BC011916_1 3 3.516 0.136 O MGC:20590 IMAGE:4310241, mRNA, LERLCCT.G (98%) complete cds. Homo sapiens, clone MGC:9275 IPI:IPI00059240.1 GP:BC011967_1 IMAGE:3866562, mRNA, complete A.ECSQYLDETCTCF.V 1 2.106 0.116 G, O (96%) cds. G.AMGDHSKKKPGTA.M 2 2.800 0.141 L.LCRADHGLLLE.R 2 2.437 0.111 Homo sapiens, Similar to serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), IPI:IPI00001037.1 GP:BC011991_1 F.LMIDQNTK.S 1 2.322 0.159 O, P member 1, clone MGC:9222 (99%) IMAGE:3859644, mRNA, complete cds. F.NKPFVFLMIDQNTK.S 2 4.102 0.315 3 4.420 0.168 F.VFLMIDQNTK.S 2 2.782 0.102 K.FNKPFVFLMIDQNTK.S 1 4.775 0.295 2 5.586 0.364 3 5.161 0.285 K.FNKPFVFLMIDQNTKSPLFMGK.V 2 2.836 0.347 3 5.111 0.381 M.SIPPEVKFNKPFVFLMIDQNTKSPLFM 3 6.002 0.478 GKVVNPTQK.- N.KPFVFLMIDQNTK.S 2 2.538 0.135 Homo sapiens, Similar to hypothetical protein LOC55565, clone MGC:20131 GP:BC012116_1 H.LLIHSEDQR.S 2 2.532 0.237 G, O IMAGE:4553333, mRNA, complete cds. P.VCGRALSSPGSLGR.H 2 2.452 0.134 Homo sapiens, clone MGC:20469 GP:BC012182_1 IMAGE:4554554, mRNA, complete V.QPAPITPTGEDVK.P 1 1.976 0.156 G cds. Homo sapiens, clone MGC:20470 IPI:IPI00151886.1 GP:BC012183_1 IMAGE:4554912, mRNA, complete I.YNSSGGFSSNTSANDTLNKVNHTSK.A 2 2.864 0.130 G (96%) cds. Homo sapiens, clone GP:BC012225_1 P.KIVNQESLTESTSLK.H 1 2.375 0.126 O IMAGE:3452587, mRNA, partial cds. Homo sapiens, clone MGC:16140 GP:BC012757_1 IMAGE:3630351, mRNA, complete E.NIASNDGPR.G 1 2.233 0.081 G cds. Homo sapiens, clone GP:BC012922_1 Y.GAFSVTEILGNFNTLALK.H 1 2.402 0.108 O IMAGE:4449401, mRNA, partial cds. Homo sapiens, Similar to RIKEN cDNA 2400002D02 gene, clone IPI:IPI00061108.1 GP:BC013049_1 N.KLKKSKDTVSEDTIRLIEK.Q 3 3.525 0.227 A MGC:17776 IMAGE:3882448, mRNA, (96%) complete cds. Homo sapiens, Similar to RIKEN cDNA 4733401F03 gene, clone IPI:IPI00061231.1 GP:BC013311_1 K.EKIDIGLPPPKVSRTQQ.L 1 2.527 0.084 G MGC:4810 IMAGE:3546083, mRNA, (92%) complete cds. Homo sapiens, Similar to RIKEN GP:BC013767_1 cDNA 2610528G05 gene, clone A.TTTTATVPTTR.P 1 1.801 0.101 O IMAGE:3875837, mRNA, partial cds. R.LAGLGLQQLDEGLFSR.L 2 4.008 0.410 R.SLTLGIEPVSPTSLR.V 2 2.825 0.280 GP:BC013934_1 Homo sapiens, clone MGC:24275 F.IIPKKLMIFLRTVIRLE.R 2 3.016 0.142 O Supplementary Table 1 128 IMAGE:3950542, mRNA, complete cds. Homo sapiens, clone MGC:19956 GP:BC013999_1 IMAGE:3936914, mRNA, complete K.EMEASGAHRDSQKAGER.D 2 3.143 0.137 P cds. Homo sapiens, clone GP:BC014055_1 L.EEQRVELVE.R 1 2.588 0.085 A IMAGE:3628973, mRNA, partial cds. Homo sapiens, clone MGC:20455 E.PSVDQGPGAGIPSALVLISIVICVSLIILIA GP:BC014077_1 IMAGE:4126671, mRNA, complete 3 3.899 0.165 A LNVLL.F cds. Homo sapiens, clone R.KAGAGKRVVFLEPLKDTAAGQNGKVR IPI:IPI00160969.2 GP:BC014103_1 2 2.569 0.100 A IMAGE:3625286, mRNA, partial cds. LF.P (95%) Homo sapiens, clone IPI:IPI00166208.1 GP:BC014124_1 L.VKEVTKSVEEAQ.L 2 3.344 0.133 G IMAGE:4561365, mRNA, partial cds. (99%) Homo sapiens, Similar to RIKEN cDNA 4930519N16 gene, clone GP:BC014127_1 Q.DELDTEAEVSR.R 1 2.061 0.101 A MGC:20742 IMAGE:4579939, mRNA, complete cds. Homo sapiens, Similar to KIAA0890 protein, clone MGC:20897 IPI:IPI00165254.1 GP:BC014237_1 G.VRKIVLATNIAETSITINDIVHV.V 2 2.666 0.162 A, O IMAGE:4553927, mRNA, complete (98%) cds. L.YPNLIQVRQGKVTRQGKFK.P 2 2.220 0.209 Homo sapiens, clone MGC:22821 IPI:IPI00026031.1 GP:BC014320_1 IMAGE:3686673, mRNA, complete L.NITYESGQVYVND.L 2 2.704 0.169 G (92%) cds. Homo sapiens, Similar to lactate dehydrogenase 1, A chain, clone GP:BC014340_1 M.IPNITQYSPHCKL.L 2 2.860 0.116 G MGC:23940 IMAGE:3935569, mRNA, complete cds. Homo sapiens, Similar to orosomucoid IPI:IPI00182215.1 GP:BC014367_1 1, clone MGC:24263 IMAGE:3934516, -.GGQEHFAHLLILR.D 2 4.438 0.504 G, O, P (98%) mRNA, complete cds. 3 3.675 0.294 G.GQEHFAHLLILR.D 2 4.046 0.363 K.EQLGEFYEALDCLRIPKSDVV.Y 2 2.838 0.224 K.NWGLSVYADKPETTK.E 1 3.106 0.345 2 4.701 0.431 K.SDVVYTDWK.K 1 2.986 0.353 2 3.447 0.393 K.SDVVYTDWKK.D 1 2.671 0.176 2 3.551 0.313 K.TYMLAFDVNDEK.N 1 3.015 0.467 2 4.145 0.430 K.TYMLAFDVNDEKNWGLSVYADKPETT 3 5.677 0.431 K.E L.SVYADKPETTK.E 2 2.477 0.210 N.WGLSVYADKPETTK.E 2 2.473 0.197 R.YVGGQEHFAH.L 2 2.739 0.335 R.YVGGQEHFAHLL.I 2 2.590 0.311 R.YVGGQEHFAHLLIL.R 2 2.791 0.133 R.YVGGQEHFAHLLILR.D 1 3.878 0.321 2 5.224 0.349 3 3.634 0.381 R.YVGGQEHFAHLLILRDTK.T 2 2.454 0.192 3 4.133 0.415 Y.VGGQEHFAHLLILR.D 2 4.467 0.359 3 4.500 0.372 Homo sapiens, hypothetical protein C.QAEAAAAANGTGGEEDDGPAAELLEK. IPI:IPI00155577.1 GP:BC014415_1 FLJ20718, clone IMAGE:4577269, 2 4.100 0.127 O, P L (91%) mRNA, partial cds. Homo sapiens, Similar to f-box only protein 17, clone MGC:11162 GP:BC014527_1 A.PEPEPEEALDLSQLPPEL.L 2 2.690 0.089 O, P IMAGE:3841901, mRNA, complete cds. R.GWRALVDGQALWLLILARDHGA.T 2 2.786 0.102 Homo sapiens, clone IPI:IPI00171360.1 GP:BC014671_1 Q.YDPETGTGLLCIEELSK.K 2 2.970 0.083 P IMAGE:4865334, mRNA, partial cds. (99%) Homo sapiens, clone R.RARRTKRHRSTLHSSLGNRARLCLRK GP:BC014678_1 3 3.689 0.114 A IMAGE:3860672, mRNA, partial cds. K.K Homo sapiens, Similar to zinc finger IPI:IPI00175389.1 GP:BC014894_1 R.LDTDDGQLPRAAPERTDAKPT.A 2 2.943 0.205 G protein 30, clone MGC:10201 (95%) Supplementary Table 1 129 IMAGE:3910185, mRNA, complete cds. Homo sapiens, clone GP:BC014930_1 A.SDLNSGNANEAVNGVR.E 2 2.674 0.082 O, P IMAGE:3919749, mRNA, partial cds. Homo sapiens, clone MGC:16471 GP:BC015088_1 IMAGE:3953782, mRNA, complete F.LKVLGPK.I 1 2.030 0.090 P cds. Homo sapiens, clone GP:BC015318_1 K.QNVNILIDTEK.F 1 2.527 0.103 G IMAGE:4415312, mRNA, partial cds. Homo sapiens, putative Rab5 GDP/GTP exchange factor GP:BC015330_1 homologue, clone MGC:21194 S.QSSQGAQSLTFSKFEEK.K 1 2.512 0.137 G IMAGE:4420279, mRNA, complete cds. Homo sapiens, hypothetical protein, GP:BC015333_1 clone MGC:21221 IMAGE:4426118, Y.ADLIPVPLTYM.I 1 2.703 0.190 O, P mRNA, complete cds. Homo sapiens, joined to JAZF1, clone G.GFGGSAAVAAATASGGKSGGGSCGG IPI:IPI00174820.1 GP:BC015704_1 MGC:10177 IMAGE:3908024, mRNA, 3 4.047 0.117 P GGSYSASSSSSA.A (98%) complete cds. Homo sapiens, clone MGC:23665 IPI:IPI00177625.1 GP:BC015792_1 IMAGE:4866941, mRNA, complete V.QLFSTVSVQYVPTWSK.E 2 2.528 0.099 A (97%) cds. Homo sapiens, hypothetical protein FLJ20457, clone MGC:8859 GP:BC015795_1 F.LTELAPLCKIYCSDGEEY.T 2 3.033 0.082 A IMAGE:3910513, mRNA, complete cds. Homo sapiens, hypothetical protein FLJ20425, clone MGC:8861 GP:BC015796_1 N.ACGESVKKIQVEK.H 2 2.639 0.108 P IMAGE:3911275, mRNA, complete cds. Homo sapiens, butyrophilin, subfamily 3, member A3, clone MGC:10692 IPI:IPI00012977.1 GP:BC015815_1 R.EMKEMGYAATEQE.I 2 3.494 0.083 P IMAGE:3677284, mRNA, complete (98%) cds. Homo sapiens, hypothetical protein FLJ11730, clone MGC:23733 GP:BC016328_1 E.DTQMYGNIIRGWDRYLTNQKNSNSK.N 2 2.547 0.096 G IMAGE:4102633, mRNA, complete cds. Homo sapiens, clone MGC:27165 IPI:IPI00178429.1 GP:BC016369_1 IMAGE:4701069, mRNA, complete A.IDYWGQGTLVTVSSASPTSPK.V 2 3.973 0.175 O, P (92%) cds. Homo sapiens, clone IPI:IPI00168922.1 GP:BC016490_1 R.QLVEELQ.S 1 2.052 0.122 P IMAGE:4341220, mRNA, partial cds. (96%) Homo sapiens, sin3-associated polypeptide, 30kD, clone MGC:13685 GP:BC016757_1 A.AAVAAVVAAAAAA.A 1 2.010 0.141 A, O, P IMAGE:4074154, mRNA, complete cds. K.GSDDDGGDSPVQD.I 1 2.117 0.099 V.AAAAAAASAGNGTGAGTGAEVP.G 2 2.876 0.083 Homo sapiens, Similar to RIKEN GP:BC016791_1 cDNA 2600001B17 gene, clone V.EIINDRTETPPPLASLNVS.K 2 2.730 0.229 O, P IMAGE:2822298, mRNA, partial cds. Homo sapiens, Similar to RIKEN C.AVHSGSSGGPLFSNHSGNLLGIITSNT IPI:IPI00146336.1 GP:BC016840_1 cDNA 1300019N10 gene, clone 2 2.504 0.109 A R.D (92%) IMAGE:3889265, mRNA, partial cds. Homo sapiens, clone MGC:10146 GP:BC016843_1 IMAGE:3904241, mRNA, complete G.GNLIVELAR.Y 1 1.935 0.108 A cds. Homo sapiens, clone MGC:21130 IPI:IPI00183633.1 GP:BC016919_1 IMAGE:4400601, mRNA, complete L.LRLLIQEFHSSPAE.K 1 2.386 0.101 A (94%) cds. Homo sapiens, clone MGC:21452 GP:BC016941_1 IMAGE:3448446, mRNA, complete S.KKVARAARFGISSVPTK.G 2 3.122 0.210 G cds. Homo sapiens, clone MGC:9466 IPI:IPI00186138.1 GP:BC017059_1 IMAGE:3914632, mRNA, complete G.RLTTINCEEGDKLKL.T 2 2.972 0.174 O (91%) cds. Homo sapiens, clone IPI:IPI00217438.1 GP:BC017179_1 R.THTGEKPYQCEE.C 1 2.330 0.094 G IMAGE:3344281, mRNA, partial cds. (94%) Homo sapiens, clone MGC:10254 GP:BC017212_1 IMAGE:4054134, mRNA, complete K.KCKEAGLLNYLLEEILDKV.H 2 2.862 0.135 G cds. Homo sapiens, Similar to quiescin Q6, IPI:IPI00003590.1 GP:BC017692_1 clone MGC:20995 IMAGE:4447666, R.EVALDLSQHK.G 2 2.547 0.259 P (98%) mRNA, complete cds.
Supplementary Table 1 130 R.SALYSPSDPLTLLQADTVR.G 2 4.964 0.441 Homo sapiens, phosphatidylinositol glycan, class B, clone MGC:21236 IPI:IPI00145121.1 GP:BC017711_1 K.KPALSFLFLSNLFLAL.Y 1 1.990 0.179 A, G IMAGE:4430974, mRNA, complete (91%) cds. L.EGSKSMNSVK.Y 2 2.223 0.213 Homo sapiens, hypothetical protein FLJ22029, clone MGC:24076 IPI:IPI00152699.1 GP:BC017957_1 A.EKQAEQSKEE.Q 1 2.629 0.094 O, P IMAGE:4607145, mRNA, complete (92%) cds. H.PFVRSSVIVRSQTFSPGER.N 2 2.336 0.106 Homo sapiens, Similar to RIKEN cDNA 2210017A09 gene, clone GP:BC018063_1 K.GLAEEVKSRWEK.E 2 3.281 0.099 A, O, P MGC:26571 IMAGE:4814899, mRNA, complete cds. K.NCKSTLMTL.N 1 1.861 0.091 Homo sapiens, clone MGC:9155 IPI:IPI00180018.1 GP:BC018123_1 IMAGE:3904914, mRNA, complete E.FWCALVEKAYAK.L 2 2.425 0.100 G, O (94%) cds. I.RLRNPWGEREWNGPWSD.T 2 2.914 0.202 Homo sapiens, Similar to immunoglobulin heavy constant IPI:IPI00182107.1 GP:BC018747_1 gamma 3 (G3m marker), clone R.DWFDPWGQGTLVTVSSASTK.G 2 2.604 0.113 G (96%) MGC:31937 IMAGE:4851063, mRNA, complete cds. Homo sapiens, SEC24 (S. cerevisiae) related gene family, member C, clone IPI:IPI00185068.1 GP:BC018928_1 G.PPTSLASASGSF.P 1 2.114 0.118 A, P MGC:14092 IMAGE:4123623, mRNA, (92%) complete cds. Y.GQFGQGDVQNGPSSTVQMQRLPGSQ 2 2.523 0.104 SFGS.P Homo sapiens gene for Ig heavy chain GP:D11016_1 C.EEQLVESGGGLVK.P 2 2.867 0.206 G, O variable region, partial cds. K.THHGATDYAAPVK.G 2 2.783 0.263 L.SKTHHGATDYAAPVK.G 2 3.257 0.319 Human mRNA for KIAA0004 gene, GP:D13629_1 K.TVQDLKQEIKALKEEIGNVQ.L 2 2.533 0.084 G complete cds. Human mRNA for phospholipase A2 IPI:IPI00105353.1 GP:D30780_1 K.QPVENQE.K 1 2.597 0.089 O, P receptor, partial cds. (99%) Human mRNA for KIAA0066 gene, IPI:IPI00014235.1 GP:D31886_1 L.EQPEVLVT.G 1 2.026 0.095 A, O, P partial cds. (94%) L.HQKLQMLNCCIERKK.A 2 2.227 0.221 Y.IPVTQEPAPMTEDLLEEQSEVLAKLGTS 3 3.603 0.180 AEGAHLR.A Human mRNA for immunoglobulin GP:D38039_1 kappa vaiable region of anti-DNA L.IYAAFIWQSGVPSR.F 2 2.806 0.113 G autoantibody. Human mRNA for a1(XIX) collagen K.GDPALAGLNGENGLKGVLGPHGPPGP IPI:IPI00185712.1 GP:D38163_1 2 2.561 0.148 A chain, complete cds. KGEK.G (94%) Human DOCK180 protein mRNA, complete cds; 180-kDa protein Q.RPKSQVMNVIGSERRFSVSPSSPSSQ IPI:IPI00015286.1 GP:D50857_1 3 3.601 0.191 G downstream of CRK; CRK SH3- QTPPPVTPR.A (94%) binding protein. Human mRNA for KIAA0135 gene, IPI:IPI00185292.1 GP:D50925_1 partial cds; The KIAA0135 gene is Y.AASDRESPGHVPSMLDA.G 1 2.022 0.146 A (97%) related to pim-1 oncogene.. Homo sapiens mRNA for NOTCH4, partial cds; Complete cds is shown in GP:D63395_1 N.HWDLLTLLEGAGPPEARHKA.T 3 3.863 0.091 O D86566; Human counterpart of mouse mammary tumor gene int-3. Homo sapiens mRNA for KIAA0147 protein, partial cds; The KIAA0147 GP:D63481_1 L.DRNQLSALPP.E 2 2.779 0.158 A, G, O, P gene product is related to adenylyl cyclase.. P.NLRELWLDR.N 1 2.137 0.085 Human mRNA for KIAA0159 gene, IPI:IPI00006668.1 GP:D63880_1 complete cds; KIAA0159 gene product F.SSDESSEEDLSAEMTEDETPK.K 3 3.848 0.125 A (94%) is related to yeast protein L8479.14.. Homo sapiens mRNA for KIAA0165 gene, complete cds; similarto IPI:IPI00017538.1 GP:D79987_1 Schizosaccharomyces pombe cut1+ F.TVFEEVCPTESKPEVPQAPRV.Q 2 2.468 0.153 P (92%) protein which regulates spindle pole body duplication.. T.QPERAQELLNEAVGR.L 2 2.211 0.121 GP:D83688_1 Human mRNA for immunoglobulin M -.EVQLVESGGGLVKPRG.S 2 5.050 0.313 G, O, P IPI:IPI00177361.1 Supplementary Table 1 131 (IgM), partial cds (VH3-N-D-N-JH4), (92%) clone UB1-17E; VH3-N-D-N-JH4. Q.LVESGGGLVKPRG.S 2 3.812 0.296 Human mRNA for KIAA0199 gene, partial cds; the KIAA0199 gene is expressed ubiquitously. the KIAA0199 IPI:IPI00166385.1 GP:D83782_1 P.YLVVVIGLENVLVLTK.S 2 3.524 0.122 P protein shows similarity to sea urchin (98%) hydroxymethylglutalyl-CoA reductase, and retains 8 hydrophobic domains.. Human mRNA for p52 and p64 IPI:IPI00098811.1 GP:D84361_1 R.EAISRVCEAVPGAKGAFKK.R 1 2.649 0.170 G isoforms of N-Shc, complete cds. (99%) Bombyx mori mRNA for cdc2-related kinase, complete cds; Bcdrk GP:D85135_1 V.KIADFGLARWLGAPAR.S 1 2.451 0.100 P (PLSGLRE); similar to Dcdrk/human PISSLRE kinase. Human mRNA for KIAA0209 gene, E.HPRFKNKPVPDQIINFYKSNYVQRFHY IPI:IPI00022449.1 GP:D86964_1 partial cds; similar to a human major 3 3.571 0.241 P SRPVRR.G (98%) CRK-binding protein DOCK180.. Human mRNA for KIAA0216 gene, IPI:IPI00017030.6 GP:D86970_1 complete cds; similar to myosin heavy D.MAPHIYAVAQTAYRAMLMSR.Q 2 2.558 0.114 O (93%) chain: Containin. Human mRNA for KIAA0225 gene, partial cds; similar to a C.elegans IPI:IPI00022495.1 GP:D86978_1 K.ECRQSLAESLFAWACQSPL.G 2 2.740 0.082 A, O, P protein encoded in cosmid (98%) K12D12(Z49069). K.LQNVEQLPPDEIKELCQSVMPA.G 2 2.459 0.216 P.RTCLHAILNILEK.G 1 2.054 0.095 2 3.287 0.206 Human mRNA for KIAA0229 gene, IPI:IPI00022500.1 GP:D86982_1 partial cds; similar to human ankyrin G.SGGGGGGSGGGGGGL.G 1 2.097 0.147 G, O, P (91%) 1(S08275). L.HLAAWKGDAQIVRLLIHQGP.S 2 2.563 0.121 Human mRNA for KIAA0231 gene, IPI:IPI00166036.1 GP:D86984_1 partial cds; similar to yeast adenylate F.ELTEMEVLSLE.L 2 3.215 0.113 G, O (97%) cyclase (S56776). K.SNYSDIPDVKNDFAFILHLADQYDP.L 3 3.633 0.082 Human mRNA for KIAA0221 gene, complete cds; similar to yeast IPI:IPI00034049.1 GP:D86988_1 A.GAGSAAGQLDAQVGPEGIL.Q 1 2.837 0.119 O, P prematurely terminated mRNA decay (93%) factor NAM7(S23408). 2 3.658 0.111 Homo sapiens immunoglobulin GP:D86996_3 A.GLTQPPSVSK.G 1 1.830 0.197 O, P lambda gene locus DNA, clone:23F1. 2 2.216 0.218 A.GLTQPPSVSKGLR.Q 2 2.918 0.264 Homo sapiens immunoglobulin IPI:IPI00154742.1 GP:D87017_3 lambda gene locus DNA, H.RSYSCRVTHEGSTVEK.T 2 3.099 0.231 G, O, P (94%) clone:75C12. K.VGVETTKPSK.Q 1 2.292 0.161 S.YLSLTPEQWKSHRSYSCRVTHEGSTV 3 3.503 0.147 EK.T Human mRNA for KIAA0268 gene, IPI:IPI00185495.1 GP:D87742_1 partial cds; Similar to Human C219- P.GNQGRQFDVNLQVPDR.A 2 2.849 0.109 G (94%) reactive peptide (L34688). S.KKHVQETRKQNMILSDEAIK.Y 2 2.265 0.109 Homo sapiens NPAT gene, exon 18 IPI:IPI00179588.1 GP:D89854_1 R.EKILSNKSLQE.K 2 2.757 0.082 O, P and complete cds. (93%) R.STTKKRKIEELDE.R 2 3.289 0.098 Human collagen alpha-2 type I mRNA, G.PPGNPGANGLTGAKGAAGLPGVAGAP IPI:IPI00181781.1 GP:J03464_1 complete cds, clone pHCOL2A1; pre- 3 3.672 0.224 A, O GLPGPRGIPGPPGAAGTTGAR.G (97%) pro-alpha-2 type I collagen. L.PGVAGAPGLPGPRGIPGPPGAAGTTG 2 2.266 0.132 AR.G Human serum amyloid A gene, IPI:IPI00006146.3 GP:J03474_1 K.RGPGGAWAAEVISNAR.E 2 3.109 0.133 O, P complete cds; amyloid A precursor. (98%) R.GPGGAWAAEVISNAR.E 2 3.021 0.143 Human Ig germline kappa L-chain V- IPI:IPI00053682.1 GP:K02096_1 region gene d, V-kappa-1 subgroup; Ig W.LPGARCDIQLTQSPSFLSASV.G 2 3.095 0.141 O, P (92%) kappa V-region d. Homo sapiens Ig rearranged alpha- IPI:IPI00220120.1 GP:L01276_1 C.EVQVLESGGGLVQPGGSL.R 2 2.518 0.110 A, G, O, P chain mRNA V-C-region, 5' end. (92%) C.EVQVLESGGGLVQPGGSLR.L 1 3.067 1.000 2 4.568 0.276 G.SFDYWGQGTLVTVSSASPTSPK.V 2 3.143 0.373 Supplementary Table 1 132 Q.VLESGGGLVQPGGSLR.L 1 2.781 0.195 2 4.532 0.228 Homo sapiens Ig rearranged gamma- GP:L01410_1 1 chain (IGHG1) mRNA subgroup VH- A.QVKLLESGGGVVQPGGSLR.L 2 4.110 0.211 P III hybridoma, partial cds. Homo sapiens Ig rearranged kappa L- GP:L01411_1 chain (IGKV) mRNA subgroup VK-I -.AELMTQSPSSLSASVGDR.V 2 4.634 0.242 G, O hybridoma, partial cds. Y.FLNWYQQKPGR.A 1 1.908 0.107 2 2.980 0.229 Homo sapiens cell-type T-cell GP:L03147_1 immunoglobulin gamma-chain, V G.KGTTVIVSSASTK.G 1 1.928 0.211 G region (IGHV@) mRNA, partial cds. Homo sapiens cell-type T-cell GP:L03150_1 immunoglobulin gamma-chain, V K.LLIYDASNSETGVPSR.F 2 3.886 0.234 O region (IGHV@) mRNA, partial cds. Homo sapiens cell-type T-cell GP:L03161_1 immunoglobulin gamma-chain, V Q.GTTVIVSPASTK.- 1 2.279 0.370 G region (IGHV@) mRNA, partial cds. 2 3.116 0.363 Homo sapiens cell-type T-cell GP:L03166_1 immunoglobulin gamma-chain, V D.SPLYSFGQGTK.L 1 2.079 0.262 G region (IGHV@) mRNA, partial cds. 2 2.886 0.209 Homo sapiens cell-type T-cell IPI:IPI00053682.1 GP:L03178_1 immunoglobulin gamma chain, V R.ASQTISSYLNWYQQK.P 2 2.871 0.156 G (93%) region (IGHV@) mRNA, partial cds. Homo sapiens immunoglobulin kappa IPI:IPI00003457.1 GP:L03555_1 light chain VJC region (IGKV) mRNA, Y.NSIEGTFGQGTK.V 1 1.820 0.162 G (98%) partial cds; putative. Human IG rearranged lambda-chain GP:L03629_1 K.VTVVGQPK.A 1 1.950 0.272 G mRNA V-J-C-region, partial cds. Human IG rearranged lambda-chain GP:L03634_1 T.VAFGGGTKLTVLGQPK.A 2 3.671 0.094 O mRNA V-J-C-region, partial cds. Human germline HRX mRNA, GP:L04284_1 I.RQLSDKALEGLSQLGLFLLQK.G 2 2.861 0.176 A, O complete cds. K.ECGQPAGQVA.V 1 1.854 0.102 R.PISRLQTRKNKKLAPSSTPSNIA.P 2 2.400 0.102 Homo sapiens (clone A5319) GP:L04773_1 rearranged Ig alpha-1 chain VH6-CH1 G.TLITVSSASPTSPK.V 2 2.852 0.121 O, P region (IGHA1) mRNA, partial cds. Q.GTLITVSSASPTSPK.V 1 1.898 0.124 2 3.115 0.175 Homo sapiens Ig rearranged heavy- chain gene V-Dk1-J4-region; This CDS feature is included to show the GP:L06226_1 translation of the corresponding N.TNYAENFQGR.V 2 2.508 0.238 G V_region. Presently translation qualifiers on V_region features are illegal.. Human Ig rearranged gamma-chain GP:L06919_1 mRNA V-region, 5' end of cds (from S.QVQLVQSGAAVK.K 1 2.359 0.101 G clone S5P3). 2 2.796 0.121 Homo sapiens (clone WR4.12VL) anti- thyroid peroxidase monoclonal GP:L12064_1 autoantibody IgK chain, V region; B R.YLNWYQQMPGK.A 2 3.648 0.320 G cell mRNA for anti thyroid peroxidase antibody. Homo sapiens (clone TR1.10VL) anti- thyroid peroxidase monoclonal GP:L12088_1 autoantibody IgK chain, V region; B -.ELVMTQSPSSLPASVGDR.V 2 2.808 0.233 G, O cell mRNA for anti thyroid peroxidase antibody. Y.DSSTLQGGVPSR.F 2 2.626 0.238 Homo sapiens (clone TR1.3VL) anti- thyroid peroxidase monoclonal GP:L12091_1 autoantibody IgK chain, V region; B A.ASNLHTGVPSR.F 2 3.174 0.338 G, P cell mRNA for anti thyroid peroxidase antibody. Homo sapiens (clone TR1.5VH) anti- thyroid peroxidase monoclonal GP:L12092_1 autoantibody IgH chain, V region; B D.NTIYLQMNSLTA.D 2 3.263 0.117 G, O cell mRNA for anti thyroid peroxidase antibody. Supplementary Table 1 133 Homo sapiens (clone TR1.5VL)anti- thyroid peroxidase monoclonal GP:L12093_1 autoantibody IgK chain, V region; B R.ASQSINSYLNWYQQK.P 2 3.088 0.279 G cell mRNA for anti thyroid peroxidase antibody. R.ASQSINSYLNWYQQKPGK.A 2 4.111 0.198 Human IgH (thyroid peroxidase- GP:L12111_1 specific Fab fragment) mRNA, partial D.NTVYLQMNSLTA.D 2 3.034 0.186 G, O cds; clone TR1.32. Human (clone: EBV R16) immunoglobulin rearranged mu-chain IPI:IPI00220120.1 GP:L12188_1 K.GLEWVSTISGSGSSKYYADSVK.G 2 4.378 0.253 G mRNA V3-D-J region, partial cds; (95%) Vh3-D-J-region; putative. Homo sapiens immunoglobulin mu chain Vh5-D-J4 region (IGHM) mRNA, IPI:IPI00018563.3 GP:L12198_1 -.EVPLVQSGAEVK.K 1 2.488 0.177 G, O partial cds; putative; immunoglobulin (97%) heavy chain. 2 3.103 0.182 Homo sapiens immunoglobulin heavy GP:L14818_1 chain VH3b region (IGH) mRNA, R.DDSKNTLYLQLNSLK.T 2 3.142 0.210 P partial cds. Homo sapiens productively IPI:IPI00220120.1 GP:L14821_1 C.EVQLVESGGSLVQPGGSLR.L 1 3.064 0.135 G, O, P rearranged IgH mRNA, V3b region. (94%) 2 5.149 0.188 Q.LVESGGSLVQPGGSLR.L 2 3.617 0.307 Human (clone rMTF) productively rearranged IgH chain gene, V region; CDR I 251..265; CDR II 308..364; FR I IPI:IPI00161059.3 GP:L15469_1 K.GLEWVGHIR.D 2 2.929 0.334 O 161..250; FR II 266..307; FR III (94%) 365..460; no stop codon because this is only the variable gene segment. Homo sapiens (B8L) rearranged rheumatoid factor immunoglobulin GP:L19276_1 -.ETVMTQSPATVSVSPGER.A 2 3.922 0.383 G light chain gene, V_region; monoclonal IgM rheumatoid factor. Q.SVTTNLAWYQQK.P 2 3.463 0.177 R.ASQSVTTNLAWYQQK.P 2 3.961 0.348 Homo sapiens (RC1L) rearranged rheumatoid factor-associated IPI:IPI00024136.1 GP:L19282_1 immunoglobulin light chain gene, Y.LAWYQEK.P 1 2.199 0.086 G (96%) V_region; monoclonal rheumatoid factor light chain; V_region. Homo sapiens (RC2) rearranged GP:L19283_1 rheumatoid foctor IgM gene, V_region; R.VTISLDTSE.N 1 1.972 0.114 G monoclonal IgM rheumatoid factor. Homo sapiens (RC2L) rearranged rheumatoid factor-associated IPI:IPI00003486.1 GP:L19284_1 immunoglobulin light chain gene, A.GQSVSRTSLAWYQQKPGQAPR.L 2 3.026 0.169 G, O (91%) V_region; monoclonal IgM rheumatoid factor light chain. G.ASSRATGSPDRFSGSGSGTDFTLTISR. 3 3.512 0.107 L Human Ig rearranged kappa-chain IPI:IPI00003486.1 GP:L19423_1 gene V-region, partial cds; anti- -.ELVLTQSPGTL.S 1 2.892 0.252 A, G, O, P (92%) concanavalin A. 2 3.440 0.140 -.ELVLTQSPGTLSL.S 2 4.232 0.249 -.ELVLTQSPGTLSLSPGER.A 1 3.105 0.257 2 5.871 0.377 3 3.958 0.133 E.LVLTQSPGTLSLSPGER.A 2 4.651 0.455 Human Ig rearranged kappa-chain GP:L19425_1 gene V-region, partial cds; anti- -.ELVLTQSPGTLSVSPGER.A 2 2.853 0.226 G concanavalin A. Human Ig rearranged kappa-chain IPI:IPI00024136.1 GP:L19433_1 gene V-region, partial cds; anti- -.ELVLTQSPATL.S 1 2.678 0.140 A, G, O, P (92%) concanavalin A. 2 4.013 0.341 -.ELVLTQSPATLSL.S 2 3.634 0.240 -.ELVLTQSPATLSLSPGER.A 1 2.876 0.194 2 5.560 0.353 3 4.628 0.257 GP:L19903_1 Human clone 0-16VH immunoglobulin -.VKLLEESGGGLVQPGGSLR.L 2 4.517 1.000 G, O, P
Supplementary Table 1 134 heavy-chain subgroup VIII mRNA V- D-J region, partial cds; binds Staphylococcal protein A (SpA). 3 4.239 1.000 Human clone 0-16VL immunoglobulin light-chain mRNA V-J region, partial GP:L19906_1 -.MAELTQSPSTLSVSPGER.A 2 2.510 0.096 G cds; binds Staphylococcal protein A (SpA). Human clone SpA3-08VL immunoglobulin light-chain mRNA V-J GP:L19909_1 G.LSAVGFGGGTK.L 1 1.828 0.134 G region, partial cds; binds Staphylococcal protein A (SpA). Human clone SpA3-18VL immunoglobulin light-chain mRNA V-J GP:L19911_1 A.ISCSGRSSKIGSNTVNW.Y 2 2.864 0.096 A, P region, partial cds; binds Staphylococcal protein A (SpA). G.TPGQRVAISCSGRSSKIGSNTVNWY.Q 2 2.826 0.186 Human rearranged IgH chain gene, GP:L23255_1 R.AEDTAVYYCGKDF.G 2 2.858 0.092 G VD23.7J6 region, partial cds. Human rearranged IgH chain gene, IPI:IPI00220120.1 GP:L23283_1 R.AEDTAVYYCAKDKVVHPSIVGA.I 2 3.152 0.126 G VDJ5 region, partial cds. (98%) Human IgH chain VDJ region mRNA, GP:L23558_1 K.KPGASVQ.V 1 1.844 0.117 G partial cds; putative. W.INPNSGDTNYAQR.F 2 2.715 0.322 Human IgH chain VDJC region GP:L23567_1 Y.LQHWGQGTLVTVSSASTK.G 2 3.241 0.308 G mRNA, partial cds; Xxx. Human DNA repair protein mRNA, IPI:IPI00016932.1 GP:L24444_1 E.DLEEAGV.Q 1 2.226 0.126 O, P complete cds. (91%) Homo sapiens integral nuclear IPI:IPI00000032.2 GP:L25941_1 envelope inner membrane protein I.ERNDAPHKNTQEKFNL.S 1 2.491 0.130 G, P (92%) (LBR) gene, complete cds. 2 2.628 0.098 Human IgM rearranged heavy chain GP:L26034_1 -.EKLLVESGGGLVKPGGSLR.L 2 3.792 0.259 G mRNA V-D-J region, partial cds. A.VSDNGVLLFAGVQCQVQLVESGGGVV IPI:IPI00145980.1 GP:L26401_1 Human Ig V-region, 5' end. 3 4.174 0.107 P QPGGSLRLS.C (98%) Homo sapiens immunoglobulin variable region mRNA, partial cds; immunoglobulin variable region used GP:L26531_1 -.EVKVVQSGAEVK.K 1 4.077 0.368 G, O by the ITC33 heavy chain (subgroup VH5) (anti-cytomeglovirus glycoprotein B (AD-1 epitope))'. 2 3.882 0.297 Homo sapiens immunoglobulin variable region mRNA, partial cds; immunoglobulin variable region used IPI:IPI00026197.1 GP:L26536_1 -.EIVMTQSPDSLAVSLGER.A 2 2.957 0.141 G by the ITC48 kappa light chain (96%) (subgroup V kappa IV) (anti- cytomeglovirus glycoprotein B (A. Homo sapiens immunoglobulin variable region mRNA, partial cds; immunoglobulin variable region used GP:L26539_1 K.SISTAYLEWSSLK.A 1 2.787 0.266 G, P by the ITC63B heavy chain (subgroup VH5) (anti-cytomeglovirus glycoprotein B (AD-1 epitope). 2 3.996 0.353 Human immunoglobulin light chain variable region; immunoglobulin variable region used by the ITC63B GP:L26540_1 R.PGQAPLMVIYK.D 2 2.687 0.111 G lambda light chain (subgroup V lambda III) (anti-cytomeglovirus glycoprotein B (AD-1 epitope)). Homo sapiens immunoglobulin kappa GP:L26890_1 chain mRNA, VJ region, partial cds; C.DIQMTQSPSSLSASVGDK.V 2 3.979 0.423 G, O putative. Homo sapiens immunoglobulin kappa GP:L26891_1 chain mRNA, VJ region, partial cds; R.NDLGWYQQQ.P 1 2.426 0.255 G, O putative. R.NDLGWYQQQPGK.A 2 3.741 1.000 Homo sapiens immunoglobulin heavy GP:L26892_1 chain (IGH) mRNA, VDJ region, partial S.GYFNYWGQGTLVTVSSASTK.G 2 3.458 0.444 G cds. Homo sapiens immunoglobulin kappa IPI:IPI00003457.1 GP:L26893_1 C.DIQMTQSPSTLSAA.V 2 3.215 0.090 G, P chain mRNA, VJ region, partial cds. (92%) C.DIQMTQSPSTLSAAVGD.R 2 3.446 0.313
Supplementary Table 1 135 R.ASQSISSWLAWYQEKPGK.A 2 4.058 0.266 S.SWLAWYQEKPGK.A 1 2.813 0.106 S.WLAWYQEKPGK.A 2 3.874 0.138 Human Ig lamda-chain V-J-C region GP:L26900_1 K.LLIHGNNNRPSGVPDR.F 2 2.502 0.199 G (HCV-3), partial cds; putative. Human Ig lambda-chain V-J-C region IPI:IPI00186348.1 GP:L26902_1 E.ASYELTQPPSVSVSPGQTAR.I 2 4.688 0.414 G, O, P (HCV-65), partial cds; putative. (94%) V.SEASYELTQPPSVSVSPGQTAR.I 2 4.373 0.433 Human Ig gamma-chain V-D-J-C GP:L26905_1 K.NSLYLQMNSLTA.E 2 3.043 0.112 O, P region (HCV-65), partial cds; putative. Human Ig rearranged kappa-chain IPI:IPI00024136.1 GP:L28045_1 gene V-Jk4 region, monoreactive, R.ASQSVSSNYLAWYQHKPGQAPR.L 2 2.519 0.280 G (91%) partial cds. Human Ig rearranged kappa-chain IPI:IPI00030205.1 GP:L28046_1 mRNA V-Jk1 region, monoreactive, A.SQSVASSYLAWYQQKPGQAPR.L 2 3.866 0.201 G (96%) partial cds. Human Ig rearranged lambda-chain GP:L28048_1 mRNA V-Jl2 region, polyreactive, K.SDSDKQKGSGVPSR.F 2 2.634 0.250 G, O partial cds. R.YKSDSDKQKGSGVPSR.F 2 4.018 0.331 Human Ig rearranged alpha-chain GP:L28049_1 mRNA VH1-DN1-JH4 region, K.LVQSGAEVKKPGVSVK.V 2 3.599 0.199 G monoreactive, partial cds. Q.VKLVQSGAEVK.K 1 2.806 0.187 2 3.120 0.184 R.DTSANTAYMELSSLR.S 2 3.225 0.080 Human immunoglobulin gamma heavy chain (IGHG) mRNA variable region, diversity region, and joining region; GP:L33033_1 This CDS feature is included to show L.VKSGGGLVKPGGSLR.L 2 2.689 0.157 G, O the translation of the corresponding V_region. Presently translation qualifiers on V_region features are il Q.LVKSGGGLVKPGGSLR.L 2 3.162 0.255 Human (clone 51C-3) 51C protein GP:L36818_1 S.RDTYAWHKQKPTGV.R 2 3.078 0.240 G mRNA, complete cds. Homo sapiens (clone pAC11) Ig kappa chain mRNA, V-region, partial cds; This CDS feature is included to IPI:IPI00024136.1 GP:L37300_1 show the translation of the L.LLYDASNR.A 2 2.603 0.230 O, P (93%) corresponding V_region. Presently translation qualifiers on V_region features are illegal.. R.LLLYDASNR.A 1 1.973 0.231 2 2.797 0.275 Homo sapiens (clones pAC32, pAC34, pAC38) Ig kappa chain mRNA, V- region, partial cds; This CDS feature is IPI:IPI00178198.1 GP:L37304_1 included to show the translation of the R.SNWPPLTFGGGTK.V 2 2.601 0.232 G (97%) corresponding V_region. Presently translation qualifiers on V_region features are illegal.. Homo sapiens Ig kappa chain mRNA, V-region, partial cds; This CDS feature is included to show the translation of IPI:IPI00030206.1 GP:L37307_1 -.DIQMTQSPGTLSLSPGER.A 2 3.031 0.165 G, O the corresponding V_region. Presently (95%) translation qualifiers on V_region features are illegal.. Homo sapiens immunoglobulin light GP:L38015_1 chain variable TTG1k1 Fabregion -.DIQMTQSPSSLSASLGDR.V 2 5.380 0.385 G, O mRNA, partial cds. Homo sapiens immunoglobulin heavy GP:L38016_1 chain variable region TTG1K1 Fab R.VTVTTDTSTR.T 2 2.542 0.100 G mRNA, partial cds. Homo sapiens Ig rearranged L-chain mRNA V region; This CDS feature is included to show the translation of the IPI:IPI00003486.1 GP:L38430_1 R.ASQSVTSSYLAWYQQKPGQAPR.L 2 3.820 0.201 G corresponding V_region. Presently (92%) translation qualifiers on V_region features are illegal.. Homo sapiens Ig rearranged H-chain mRNA V region; This CDS feature is IPI:IPI00220120.1 GP:L38433_1 included to show the translation of the C.EVQLLETGGGLVQPGGSLR.L 2 2.653 0.151 G (96%) corresponding V_region. Presently translation qualifiers on V_region Supplementary Table 1 136 features are illegal.. Human clone rev9Fd immunoglobulin GP:L38560_1 heavy chain, V3-J-C1 region, mRNA, K.NFDHWGQGTLVTVSSASTK.G 2 3.997 0.520 G partial cds. Human clone rev16/20Fab, GP:L38561_1 immunoglobulin heavy chain, V3-J-C1 P.PDYWGQGTLVSVSSASTK.G 2 3.090 0.167 G region, mRNA, partial cds. Human clone tat107Fab, IPI:IPI00017248.1 GP:L38565_1 immunoglobulin lambda light chain, N.HSINMFAGSSYLSLTPEQWK.S 2 3.075 0.215 P (92%) V4-J-C1 region, partial cds. Human anti-ssDNA antibody light chain variable region mRNA, complementarity determining regions 1-3 and framework regions 1-4; This IPI:IPI00022862.1 GP:L39959_1 -.EVVMTQSPATLSVSPGER.A 1 2.327 0.329 G, O, P CDS feature is included to show the (92%) translation of the corresponding V_region. Presently translation qualifiers on V_r 2 4.301 0.375 E.VVMTQSPATLSVSPGER.A 2 4.562 0.253 Homo sapiens (clone ASPBL26) IPI:IPI00030206.1 GP:L40642_1 immunoglobulin kappa light chain R.FLIYGA.S 1 1.873 0.086 G (91%) mRNA, partial cds; putative. Homo sapiens (clone ASPBL3) IPI:IPI00141670.1 GP:L40646_1 immunoglobulin kappa light chain Y.LAWYQQTPGQAPR.L 2 3.874 0.415 G (92%) mRNA, partial cds; putative. Homo sapiens (clone BCSYN2) GP:L40654_1 immunoglobulin kappa light chain R.LLIYDASKR.A 2 2.926 0.081 A, G mRNA, partial cds; putative. S.CRASQSVGDHLAWYQHKPGQAPR.L 2 3.067 0.149 W.YQHKPGQAPRLLIYDASKRATGIPGR. 2 2.357 0.149 F Homo sapiens (clone ASSYN5) IPI:IPI00024136.1 GP:L40659_1 immunoglobulin kappa light chain S.CRASQNVSSSYLAWYQQKPGQAPR.L 3 3.982 0.202 G (91%) mRNA, partial cds; putative. Homo sapiens (clone BCSYN3) GP:L40665_1 immunoglobulin kappa light chain R.ASQSITSTYLAWYQQKPGQAPR.L 2 3.382 0.318 G mRNA, partial cds; putative. T.FSGSGSGTDFTLTVTR.L 1 2.480 0.273 2 3.116 0.335 Homo sapiens (clone ASSYN10) GP:L40667_1 immunoglobulin kappa light chain R.FSGSGSGTDFTLTIDR.L 2 4.249 0.432 G mRNA, partial cds; putative. Homo sapiens (clone BCPBL9) IPI:IPI00030206.1 GP:L40673_1 immunoglobulin kappa light chain R.FSGSESGTDFTLTISR.L 2 2.552 0.228 G (92%) mRNA, partial cds; putative. Homo sapiens (clone BCSYN14) IPI:IPI00030206.1 GP:L40684_1 immunoglobulin kappa light chain K.PGQAPSLLIYGASSR.A 2 4.332 0.399 G (91%) mRNA, partial cds; putative. Homo sapiens (clone SP2) IPI:IPI00141670.1 GP:L40689_1 immunoglobulin kappa light chain A.SQSVVSNYLGWYQQK.P 1 2.881 0.300 G, O (91%) mRNA, partial cds; putative. 2 3.675 0.199 A.SQSVVSNYLGWYQQKPGQAPR.L 2 3.798 0.133 Homo sapiens (clone ITPBL11) IPI:IPI00030206.1 GP:L40713_1 immunoglobulin kappa light chain R.ASQSVSTSYLAWYQQKPGQAPR.L 2 3.132 0.332 G (94%) mRNA, partial cds; putative. Homo sapiens (clone LK27) GP:L40740_1 immunoglobulin kappa light chain A.SQSGFSRFLAWYQHQPGQAPR.L 2 2.430 0.212 G mRNA, partial cds; putative. S.QSGFSRFLAWYQHQPGQAPR.L 2 2.753 0.180 Homo sapiens ZFOC1 mRNA, partial IPI:IPI00166563.1 GP:L41669_1 C.IHQRVHTGEKPYR.C 2 2.576 0.126 G, P cds. (98%) Homo sapiens (clone a5vl) immunogloublin light chain mRNA, V- region; This CDS feature is included to GP:L43083_1 show the translation of the -.XVQLLESGGGLVQPGGSLR.L 1 2.302 0.099 G corresponding V_region. Presently translation qualifiers on V_region features are illegal.. 2 2.792 0.270 Homo sapiens (clone a5vl) immunogloublin light chain mRNA, V- IPI:IPI00186348.1 GP:L43084_1 -.SYELTQPPSVSVSPGKTAR.I 2 4.831 0.504 A, G, O, P region; This CDS feature is included to (96%) show the translation of the Supplementary Table 1 137 corresponding V_region. Presently translation qualifiers on V_region features are illegal.. L.TQPPSVSVSPGKTAR.I 2 2.249 0.328 Q.PPSVSVSPGKTAR.I 1 2.552 0.341 S.YELTQPPSVSVSPGKTAR.I 2 4.253 0.342 Y.ELTQPPSVSVSPGKTAR.I 2 2.748 0.305 Homo sapiens (clone h3vl) immunogloublin light chain mRNA, V- region; This CDS feature is included to IPI:IPI00017248.1 GP:L43090_1 show the translation of the R.PGQAPVIVIYGK.N 2 3.605 0.224 G, O (92%) corresponding V_region. Presently translation qualifiers on V_region features are illegal.. S.SEVTQDPAVSVALGQTVR.I 2 2.426 0.300 Human Cu/Zn superoxide dismutase (SOD1) gene, exon 5; with mutation IPI:IPI00218733.1 GP:L44139_2 changing codon 102 from Asp- Gly A.DKDGVADVSIEGSVISLSGDHC.I 2 2.716 0.086 O (99%) and causing amyotrophic lateral sclerosis. Murine/Human chimeric interleukin-2 receptor-specific Ig mRNA, heavy chain variable region; This CDS feature is included to show the GP:L48726_1 R.SQLFLKMN.S 1 2.022 0.166 G translation of the corresponding V_region. Presently translation qualifiers on V_region features are illegal.. Homo sapiens MHC class I B*2701 GP:L76935_1 R.RGHGGSDHPAQVGGGPCGGAAES.L 2 2.896 0.094 G mRNA, partial cds. Human Ig germline kappa-chain C- region from kappa-deficient individual GP:M11736_1 D.YEKHKVYAGEVTHQGLSSPVTK.S 3 4.032 0.236 G, O, P (isolate gEV-3), allotype Inv3; Ig non- functional kappa-chain (C-region). E.KHKVYAGEVTHQGLSSPVTK.S 3 3.977 0.272 K.ADYEKHKVYAGEVTHQGLSSPVTK.S 2 2.321 0.127 3 4.889 0.300 K.HKVYAGEVTHQGLSSPVTK.S 2 2.397 0.197 K.VDNALQSGNSQESVTEQESK.D 2 4.325 0.460 K.VDNALQSGNSQESVTEQESKDS.T 2 3.627 0.256 N.ALQSGNSQESVTEQESK.D 2 3.695 0.270 S.KADYEKHKVYAGEVTHQGLSSPVTK.S 3 4.174 0.317 Y.AGEVTHQGLSSPVTK.S 2 4.214 0.461 Y.EKHKVYAGEVTHQGLSSPVTK.S 2 2.633 0.081 3 4.631 0.352 Y.SLSSTLTLSKADYEKHKVYAGEVTHQG 3 3.962 0.165 LSSPVTK.S Human apolipoprotein B-100 mRNA, IPI:IPI00022229.1 GP:M14162_1 complete cds; apolipoprotein B-100 K.AVSMPSFSIIGSDVR.V 2 4.149 0.403 O, P (97%) precursor. K.VPLLLSEPININDALEMR.D 2 5.376 0.397 3 4.817 0.257 R.TLADLTLLDSPIKVPLLLSEPININDALE 3 5.645 0.452 MR.D Human (fetal) rearranged IgM chain GP:M18509_1 VDJ region mRNA, clone 13P1; V-D- R.AEDTAVYYCAFSGAA.A 2 3.174 0.090 G N-region. Human rearranged IgH-chain gene GP:M18808_1 (HP1), VDJ4-region, clone 687.2; N.YAQTFQGR.V 1 1.970 0.172 G precursor VD4-region. S.QEQLVQSGAEVK.K 2 2.544 0.090 Human P450XVIIA-1 (steroid 17- IPI:IPI00006665.1 GP:M19489_1 alpha-hydroxylase/17,20 lyase) gene, F.KDGDQKLEK.I 1 2.048 0.107 G, O (94%) complete cds; cytochrome P450c17. L.IKKGKDFSGRPQMATLDIASNNRKGIAF 3 3.506 0.129 ADSGAHWQLHRR.L Human laminin B1 mRNA, complete GP:M20206_1 K.KTLDGELDGKYK.K 2 2.522 0.085 O cds; laminin B1. Human kappa-immunoglobulin germline pseudogene (Chr22.4) IPI:IPI00164744.1 GP:M20707_1 L.SLPVTPGEPASISCRSSESLL.D 2 2.699 0.207 G variable region (subgroup V kappa II); (99%) Ig kappa chain. GP:M29467_1 Human Ig rearranged kappa-chain K.SSQSLLYSSNNK.N 2 3.437 0.333 G IPI:IPI00026197.1 Supplementary Table 1 138 mRNA V-J1-region, hybridoma AE6-5, (99%) 5' end; Ig kappa-chain V-J1-region precursor. Human DNA-binding protein (mbp-1) IPI:IPI00013444.1 GP:M32019_1 mRNA, complete cds; DNA-binding A.EIEHSSTESSFDSTLSRSLSRES.S 2 3.281 0.169 O, P (92%) protein. F.LNKAEFLMIPAGLNTLNVPGCH.R 2 2.409 0.102 S.PVSFQELNRTGKSGSLKVIGI.S 2 2.425 0.133 Human Ig rearranged kappa-chain GP:M33060_1 mRNA V1-J2 region, 5' end; kappa- A.SQSINRFLNWYQQKPGK.A 2 4.098 0.095 G chain V-J region precursor. C.DLKMTQSPSSL.P 2 3.489 0.288 Human Ig rearranged mu-chain gene GP:M33619_1 V-region, subgroup VH-IV, exon 2; V- S.QLQLPESGPGLVR.P 2 3.499 0.253 G, O, P region precursor. Human (clones HT-[125,133]) alpha-2 GP:M33653_1 type IV collagen (COL4A2) mRNA, G.PRGKLGDMGPLGPQGPLGK.D 1 1.946 0.161 G complete cds. Human Ig active H-chain gene V-D-J6 GP:M36953_1 C.EVELVESGGGSVKPGGSLR.L 2 4.149 0.272 G, O, P region. E.LVESGGGSVKPGGSLR.L 2 4.098 0.294 K.TEGGTIDYAASVK.G 2 2.737 0.145 Human Ig active lambda-chain gene GP:M36956_1 R.FSGSILGDK.A 1 2.064 0.152 G V-J region. Human profilaggrin gene, 3' end; IPI:IPI00218610.1 GP:M60494_1 R.DRGHRGSRGSQASDQEG.H 2 2.538 0.168 O potential; putative. (92%) GP:M60502_1 Human profilaggrin mRNA, 3' end. H.SEDSDTQSVSAHR.Q 1 2.080 0.115 G Mus musculus domesticus immunoglobulin kappa variable region GP:M61046_1 -.DIVLTQSPASL.A 2 3.758 0.303 G (Igk-V) mRNA, partial cds; anti-human CD4 antibody. R.FTGSGSGTDFTLN.I 1 1.843 0.094 Human major histocompatibility GP:M61744_1 complex-binding protein-2 (MBP-2) L.EDLHKAAEKHSMSSISTDH.Q 2 2.977 0.227 O, P mRNA, partial cds. Human Ig active gamma-chain V(H), GP:M71219_1 D(J), J(H) mRNA partial cds, clone I.NPDTSKNLFSLQLKSVTP.E 2 3.080 0.241 P EX8. Homo sapiens clone E10 immunoglobulin heavy chain VDJC GP:M71221_1 Q.GTAVTVSSASTK.G 1 2.241 0.081 G, O region mRNA, partial cds; immunoglobulin gamma chain. 2 3.440 0.092 Human Ig active gamma-chain V(H), GP:M71231_1 D(J), J(H) mRNA partial cds, clone Q.GSLVTVSSASTK.G 1 2.461 0.082 G FD2. 2 3.213 0.098 Human Ig rearranged light-chain gene IPI:IPI00053682.1 GP:M74020_1 C.DIQMTQSPSSPSASVGDR.V 2 3.992 0.447 G, O V region; V kappa 1 family. (97%) Human Ig rearranged light-chain GP:M74022_1 mRNA V region; related to R.ASQSLNSNLAWYQQK.P 2 4.493 0.360 G HumvK328. Homo sapiens immunoglobulin kappa GP:M80920_1 light chain VJ region (IGL@) mRNA, R.ASQSISSYLNWYQHKPGK.A 2 3.683 0.263 G partial cds. Human Ig rearranged H-chain gene IPI:IPI00007892.1 GP:M82927_1 V3-D-J-region, partial cds, clone LJ11; K.SKTDGGSTDYAAPVK.G 2 2.711 0.158 G, O (91%) V3-D-J region. S.KTDGGSTDYAAPVKGK.F 2 2.227 0.123 Human hepatitis B surface antigen GP:M88311_1 antibody variable domain mRNA, S.NSERPSGVPDR.F 2 2.561 0.115 G partial cds; variable region. Human anti-glycoprotein 120 monoclonal antibody variable region and diversity region mRNA; This CDS feature is included to show the IPI:IPI00003489.1 GP:M88499_1 G.EIVLTQSPGTLSLSAGER.A 2 3.059 0.224 G translation of the corresponding (95%) V_region. Presently translation qualifiers on V_region features are illegal.. Saccharomyces cerevisiae ribosomal protein L4 (RPL4B) and GP:M88608_1 ribonucleoprotein-1 (RNP1) genes, N.KYRPETAAEKK.E 1 1.930 0.122 G complete cds; related to ribosomal protein L7a of mouse and human. Supplementary Table 1 139 Homo sapiens c-erb B2/neu protein IPI:IPI00103833.1 GP:M95667_1 P.QPPSPREGPLPAARPAGATLERAK.T 2 2.564 0.123 G (ERBB2) gene, partial cds. (99%) Human immunoglobulin kappa light GP:M95723_1 Y.GTSTLQSGVPSR.F 2 3.074 0.221 G chain (IGK) mRNA. Human Ig germline H-chain gene V GP:M99401_1 C.EVQLVESGGGLVQPGPSLR.L 2 3.606 0.236 G region, partial cds. Human (clone HG2B10H) Ig GP:M99598_1 rearranged H-chain mRNA V-region, C.QVQLVESGGDLVKPGGSLR.L 1 3.159 0.202 G, P 5' end. 2 3.417 0.319 Q.LVESGGDLVKPGGSLR.L 2 4.230 0.373 Homo sapiens immunoglobulin kappa IPI:IPI00003457.1 GP:M99603_1 light chain V region (IGKV) mRNA, R.ASQSISTWLAWYQQKPGK.A 2 3.057 0.269 G (95%) partial cds. Human (clone R1C8H) Ig rearranged GP:M99604_1 A.DVQLVQSGAEVK.K 1 3.086 0.213 G, O H-chain mRNA V-region, 5' end. 2 3.718 0.236 Homo sapiens anti-tetanus antibody kappa chain variable region gene, partial cds; subgroup I, J4; This GP:S55289_1 S.QDISDRLAWYQQKPGKVPK.V 2 3.473 0.096 G sequence comes from Fig. 4B; conceptual translation presented here differs from translation in publication. anti-tetanus antibody heavy chain variable region {subgroup III J4} [human, hybridoma, cell line TT117 B GP:S55290_1 cells, heteromyeloma GLI-H7, K.GPSVFPLAPSSKSK.L 2 2.662 0.262 G Genomic Recombinant, 441 nt]; precursor; ; This sequence comes from Fig. 5A. anti-tetanus antibody kappa chain variable region {subgroup I J4} [human, hybridoma, cell line TT117 B GP:S55292_1 cells, heteromyeloma GLI-H7, G.EFVLTQSPGTLSLSPGDR.A 2 3.119 0.121 G, P Genomic Recombinant, 451 nt]; precursor; ; This sequence comes from Fig. 5B. Homo sapiens anti-Hib capsular polysaccharide immunoglobulin light chain variable region gene, partial cds; GP:S57178_1 IgVL; This sequence comes from Fig. -.SYELTQPPSVSVSPGTTAR.I 2 3.879 0.423 O, P 4; conceptual translation presented here differs from translation in publication. V kappa 4=immunoglobulin light chain variable region {complementarity determining regions} [human, CD5+ IPI:IPI00026197.1 GP:S62210_1 tonsillar B cells, mRNA PartialMutant, -.DIVMTKSPDSL.A 1 2.181 0.125 G, O, P (99%) 303 nt]; This sequence comes from Fig. 3; conceptual translation differs from that in published reference; 2 3.218 0.099 -.DIVMTKSPDSLAVSLGER.A 1 3.216 0.268 2 5.770 0.382 3 4.979 0.361 Ig V lambda III J lambda 1=anti-HIV gp120 antibody light chain variable GP:S67986_1 region [human, hybridoma S1-1, K.SGQAPVLVVYDDSDRPSGIPER.F 2 3.059 0.274 G mRNA Partial, 324 nt]; This sequence comes from Fig. 2B. Q.SQLTQPPSVSVAPGQTAR.I 2 2.414 0.288 R.FSGSNSGTTATLTISR.V 2 2.795 0.284 AML1-EVI-1=AML1-EVI-1 fusion protein {rearranged translocation} [human, leukemic cell line SKH1, K.MFKDKVSPLQNLASINNKKEYSNHSIFS IPI:IPI00218530.1 GP:S69002_1 3 4.318 0.194 A mRNA Mutant, 5938 nt]; transcription P.S (97%) factor; This sequence comes from Fig. 2. Homo sapiens neoplasm-related C140 GP:S71022_1 product mRNA, partial cds; This K.QLASGLLLVTGPLVSIEFLYE.E 2 3.105 0.092 O sequence comes from Fig. 4. Ig V kappa [human, Waldenstrom's IPI:IPI00026198.1 GP:S71065_1 macroglobulinemia patient WM7, K.NYLTWYQQKPGQPPK.L 2 2.952 0.195 G (96%) Genomic, 285 nt]; Unknown. GP:S71083_1 Ig V kappa [human, hairy cell R.NDLGWYQQKPGQ.A 2 4.010 1.000 G, O, P IPI:IPI00178276.1 Supplementary Table 1 140 leukemia patient HC1, Genomic, 264 (92%) nt]; Unknown. Ig Vkappa=immunoglobulin light chain variable region {STL-87} [human, follicular lymphoma patient, lymph IPI:IPI00026197.1 GP:S71519_1 K.SSQSILYSSNDK.N 2 3.934 0.260 G node tumour cells, Genomic, 342 nt]; (93%) immunoglobulin light chain variable region. IgH=T-cell receptor V beta-specific IgM kappa autoantibody heavy chain IPI:IPI00182107.1 GP:S72729_1 variable region [human, IARC307 cell G.WWVYYYYMDVWGK.G 2 2.960 0.103 G, P (97%) line, mRNA Partial, 459 nt]; This sequence comes from Fig. 2A. K.GTTVTVSSGSRS.A 1 2.020 0.173 Homo sapiens transgenic-JHD mouse #5250 immunoglobulin heavy chain GP:S73615_1 variable region (IgG VH251) mRNA, K.NTLYLQMNSLGS.E 2 3.116 0.088 O, P partial cds; immunoglobulin heavy chain variable region. Homo sapiens IgM autoantibody heavy chain mRNA, partial cds; anti- GPIIb; anti-platelet glycoprotein Ia/IIa; GP:S73912_1 This sequence comes from Fig. 4; Ig -.EVQLVXSGGGLVKPGGSLR.L 1 2.944 0.175 G, O, P VH; Vh domain; author's translation differs from conceptual translation; heavy chain. 2 3.593 0.186 V.QLVXSGGGLVKPGGSLR.L 2 2.266 0.207 Ig VH4=Ig heavy chain variable region {clone F30} [human, systemic lupus GP:S74498_1 -.EVQLLQSGPGLVKPSETL.S 1 2.546 0.119 G erythematosus, mRNA Partial, 385 nt]; This sequence comes from Fig. 6. IgH=immunoglobulin heavy chain variable region {clone M3} [human, GP:S75888_1 multiple myeloma patient, mRNA G.IDSDGSSTYYADSVK.G 2 3.206 0.342 G Partial, 225 nt]; immunoglobulin heavy chain variable region. Ig VL=anti-CD19 antibody light chain variable region [human, B43 GP:S78338_1 hybridoma cells, mRNA Partial, 342 -.ELVLTQSPASL.A 1 2.246 0.081 G nt]; This sequence comes from Fig. 3B. CHN=steroid/thyroid orphan receptor homolog gene [human, fetal brain, mRNA Partial, 2714 nt]; steroid/thyroid orphan receptor homolog gene; This GP:S81243_1 L.PLGAAAAAGSQAAALESH.P 1 2.262 0.121 G sequence comes from Fig. 4; No start codon was found. N-terminal of protein truncated by chromosomal brea endothelin-A receptor delta 3-4=ET- AR delta 3-4 {alternatively spliced} IPI:IPI00002187.1 GP:S81545_1 [human, lung, mRNA Partial, 1032 nt]; N.VFKFYQDVK.D 1 2.070 0.095 A (94%) ET-AR delta 3-4; This sequence comes from Fig. 3A. BB1=malignant cell expression- enhanced gene/tumor progression- enhanced gene [human, UM-UC-9 bladder carcinoma cell line, mRNA, GP:S82470_1 P.HLPGLAGAALPRGSASLRPLLRR.A 2 2.553 0.162 G 1897 nt]; malignant cell expression- enhanced gene/tumor progression- enhanced gene; This sequence comes from Fig. 4A. Mc5 VHCH1=anti-human breast carcinoma IgG1 heavy chain variable and constant regions [mice, Mc5 hybridoma cells, mRNA Recombinant GP:S83372_1 -.EVKLVESGGGLVQPGGSLK.L 1 2.878 0.112 G, O, P Partial, 660 nt]; anti-human breast carcinoma IgG1 heavy chain variable and constant regions; This sequence comes from F 2 4.965 0.285 Caenorhabditis elegans cosmid C18H2, complete sequence; contains GP:U00040_1 an ANK repeat similar to ANK motifs 2 K.NIIGIMHSDFNK.L 2 2.267 0.133 A, P and 12 of human ankyrin; contains similarity to Pfam domain PF00023 Supplementary Table 1 141 (ank), Score=37.4, E-value=1.1e-07, N=1; coded for by the following C. elegans L.DIDPGKLDELLNLDS.A 2 2.938 0.129 T.MVARVTNAISLEAGAIRKTLKLTDVV.S 2 2.452 0.106 Human immunoglobulin heavy chain IPI:IPI00217045.1 GP:U00492_1 variable region (clone Amu1c9-3) L.RSEDTAVYYCAGDL.T 2 3.086 0.101 G (96%) mRNA, partial cds. Human immunoglobulin heavy chain GP:U00508_1 variable region (clone 1g11-3) mRNA, -.EVQLVDSGGGLVKPGGSLR.L 2 3.302 0.329 G partial cds. Human immunoglobulin heavy chain IPI:IPI00220120.1 GP:U00509_1 variable region (clone 1g4-3) mRNA, K.GLEWVSAISGSGSTYYADSVK.G 2 2.797 0.252 G (96%) partial cds. Human immunoglobulin heavy chain GP:U00512_1 variable region (clone Agamma11-3) K.KPGASLK.V 1 1.955 0.155 G mRNA, partial cds. Human immunoglobulin heavy chain IPI:IPI00182107.1 GP:U00538_1 variable region (clone Agamma8-3) -.EVQLVESGGGLVR.P 2 2.975 0.338 G (92%) mRNA, partial cds. Human immunoglobulin heavy chain GP:U00569_1 variable region (clone Amu78-1) Q.GLEWMGWINPK.T 2 2.906 0.208 G mRNA, partial cds. R.QAPGQGLEWMGWINPK.T 2 3.402 0.191 Homo sapiens immunoglobulin heavy GP:U00590_1 chain variable region mRNA, partial K.KSLYLQMDSLR.V 2 3.989 0.137 G cds. Human Ig light chain V-J region IPI:IPI00022862.1 GP:U03401_1 A.WYQQQPGQAPR.L 2 2.906 0.097 G, O, P mRNA, partial cds. (93%) N.LAWYQQQPGQAPR.L 2 3.999 1.000 R.ASQSVSTNLAWYQQQPGQAPR.L 2 4.135 0.296 W.YQQQPGQAPR.L 1 2.002 0.162 Homo sapiens clone 28S1 - IPI:IPI00030205.1 GP:U03482_1 immunoglobulin kappa chain V region .EIVLTQSPGTLSLSPGERATLSCRASQS 3 3.927 0.148 G (94%) mRNA, partial cds. VTY.N Homo sapiens clone 37S4 IPI:IPI00030205.1 GP:U03483_1 immunoglobulin kappa chain V region R.ASQSVSSGYLAWYQQKPGQAPR.L 2 2.734 0.150 G (97%) mRNA, partial cds. Homo sapiens clone 25S5 GP:U03484_1 immunoglobulin kappa chain V region -.EIVLTQSPGTLSLSPGEGA.T 2 3.013 0.316 G mRNA, partial cds. S.QYFGSNYLAWYQQKPGQAPR.L 2 3.212 0.102 Human rheumatoid factor D1 IgG light IPI:IPI00178229.1 GP:U03897_1 chain VK3 region rearranged R.SNWPWTFGQGTK.V 1 1.858 0.171 G (99%) (humka3d1) gene, partial cds. Synthetic construct clone pHCMV37HuVHN humanized immunoglobulin heavy chain complete GP:U05275_1 variable region (IgH) gene, partial cds; S.SVTAADTAVYYCANMITTSAYW.Y 2 2.661 0.122 A Human framework amino acid Arg94 mutated to Asn94, numbering system according to Kabat.. Human ribosomal protein S1 homolog GP:U05589_1 mRNA, partial cds; ribosomal protein L.DVMSETNNEFLAALESAA.D 2 2.473 0.121 G, P S1 homolog. V.KNPADVLTKGDKVDVKILA.L 2 2.530 0.155 Human monoclonal antibody CA4 Ig heavy chain variable region mRNA, partial cds; monoclonal antibody GP:U06787_1 -.EVQLVESGGGLVTPGGSLR.L 2 3.732 0.245 G, O specific for the Haemophilus influenzae type b capsular polysaccharide. Human monoclonal antibody CA4 Ig light chain variable region mRNA, partial cds; monoclonal antibody GP:U06788_1 R.ASQSVTSNYLAWYQQK.P 2 3.996 0.289 G specific for the Haemophilus influenzae type b capsular polysaccharide. R.ASQSVTSNYLAWYQQKPGQAPR.L 2 2.998 0.128 Human clone JL11 immunoglobulin GP:U07427_1 kappa chain (IgK) mRNA, VKIII-JK1 A.SQSISNSLAWYQHKPGQAPR.L 2 3.255 0.184 G region, partial cds. Human clone JL12 immunoglobulin GP:U07428_1 kappa chain (IgK) mRNA, VKIII-JK5 R.LLIYEASNR.A 2 2.881 0.185 G region, partial cds. Supplementary Table 1 142 Human clone JL15 immunoglobulin IPI:IPI00030205.1 GP:U07431_1 kappa chain (IgK) mRNA, VKIII-JK2 R.ASQSVSSNYLAWYQQK.P 1 3.358 0.226 G (92%) region, partial cds. 2 2.253 0.273 R.ASQSVSSNYLAWYQQKPGQAPR.L 2 3.991 1.000 R.LLIYSASSR.A 1 1.958 0.221 Human clone JL18 immunoglobulin GP:U07434_1 kappa chain (IgK) mRNA, VKIII-JK4 A.WYQKKPGQAPR.L 2 3.027 1.000 G, O, P region, partial cds. N.SYLAWYQKK.P 1 2.551 0.310 2 2.977 0.181 N.SYLAWYQKKPGQAPR.L 2 3.713 1.000 S.YLAWYQKKPGQAPR.L 2 4.407 1.000 W.YQKKPGQAPR.L 1 1.983 0.094 Y.LAWYQKKPGQAPR.L 2 3.269 1.000 Human clone JL5 immunoglobulin IPI:IPI00030205.1 GP:U07452_1 kappa chain (IgK) mRNA, VKIII-JK1 R.ASQSVTNNYLAWYQQK.P 2 2.701 0.132 G (92%) region, partial cds. Human clone JL58 immunoglobulin IPI:IPI00030205.1 GP:U07456_1 kappa chain (IgK) mRNA, VKIII-JK2 A.SQSVNSNYLAWYQQKPGQ.A 2 3.428 0.125 G (92%) region, partial cds. R.ASQSVNSNYLAWYQQK.P 2 4.170 0.256 R.ASQSVNSNYLAWYQQKPGQAPR.L 2 3.054 0.108 Human clone JL77 immunoglobulin GP:U07470_1 kappa chain (IgK) mRNA, VKIII-JK2 R.ASQSVNTNLAWYQHKPGQ.A 2 3.299 0.257 G region, partial cds. Human myeloma immunoglobulin GP:U07985_1 heavy chain Fd region V-D-J-CH1 T.MVIVSSASTKGPSVFPLAPSSK.S 2 3.436 0.324 G mRNA, partial cds. Human lymphoma immunoglobulin IPI:IPI00004638.1 GP:U07988_1 IgM heavy chain Fd fragment mRNA, R.INPNSGGTNYAQR.F 2 2.906 0.384 P (93%) partial cds. Human Burkitt's lymphoma IPI:IPI00003457.1 GP:U07989_1 immunoglobulin kappa light chain -.ELQMTQSPSTLSASVGDR.V 2 3.023 0.181 G (91%) mRNA, partial cds. Human immunoglobulin heavy chain, GP:U09069_1 S.TYYNPSLSSR.I 2 3.203 0.233 G V-region (SPH1.8) mRNA, partial cds. Human isolate 1 clone 2 from Graves' orbital fat tissue, immunoglobulin GP:U09882_1 K.LMIYDVSDRPSGVSNR.F 2 2.648 0.086 G lambda chain variable region mRNA, partial cds. Human isolate 1 clone 5 from Graves' orbital fat tissue, immunoglobulin GP:U09888_1 R.FSGSKSGNTASLTVSGLQAEDEAN.Y 2 2.646 0.144 G, P lambda chain variable region mRNA, partial cds. S.SDVGGYDYVPWYQQHPGKVPK.L 2 2.435 0.206 Human isolate 7 clone 10 from Graves' orbital fat tissue, GP:U09893_1 R.FSGSNSENTATLTISR.V 2 3.377 0.401 O, P immunoglobulin lambda chain variable region mRNA, partial cds. Human isolate 7 clone 4 from Graves' orbital muscle tissue, immunoglobulin GP:U09908_1 K.LLIYSTNQR.P 2 2.516 0.142 G lambda chain variable region mRNA, partial cds. Xiphophorus maculatus 163A ZF1 (Zf1) gene, complete cds; similar to GP:U12777_1 human zinc finger Y-chromosomal I.KSKHGADLPFK.C 1 2.163 0.104 A protein ZFY, Swiss-Prot Accession Number P08048. Human autoantigen mRNA, complete GP:U17474_1 cds; target for autoantibodies in P.DVISSASTALSQDIPEIASEA.L 2 3.063 0.097 O human autoimmune diseases. Gallus gallus chS-Rex-b mRNA, complete cds; similar to human NSP GP:U17606_1 S.KVSSKDSGKRSPLALPLLPFLNK.Q 2 2.779 0.143 G A: encoded by GenBank Accession Number L10333. Human GABA/noradrenaline GP:U17986_1 R.VWPHPLGAPGQAGESPEQRR.Q 2 2.562 0.102 P transporter mRNA, complete cds. Human chromosome 17q12-21 GP:U18920_1 -.GYLHRLSDPTLHSHPFLSPR.S 2 3.588 0.194 A, G mRNA, clone pOV-3, partial cds. Mus musculus Smage-1 protein gene, complete cds; similar to product GP:U19031_1 encoded by GenBank Accession A.LRDQAGGVPR.R 2 2.555 0.116 G, O Number U10686, human MAGE protein. Supplementary Table 1 143 Human rearranged immunoglobulin IPI:IPI00178254.1 GP:U19884_1 -.AIRITQSPSSLSA.S 2 3.214 0.301 G light chain mRNA, partial cds. (95%) Staphylococcus aureus MHC class II analog gene, complete cds; similar to GP:U20503_1 product encoded by human MHC L.DTNEASAAAKQIDKSSSSLHHGY.S 2 3.082 0.125 O class II HLA-DR-beta-7, GenBank Accession Number M96130. Human rearranged Ig kappa light GP:U21248_1 chain V region (Vkappa3) mRNA, -.MAELTQSPTTLSVSPGER.A 2 2.675 0.098 G, O, P partial cds, clone JMpFv2-40 VL. Human rearranged Ig mu heavy chain V region (VH1) mRNA, partial cds, clone JM 0-131 VH; antibody with GP:U21266_1 W.INPDSGITGYAQNFQGR.V 2 3.320 0.086 O intrinsic binding activity for the human sialoprotein, protein Fv, a VH region- specific Fab-binding protein. Drosophila melanogaster nervy (nvy) mRNA, complete cds; similar to the human proto-oncogene MTG8/ETO, A.AAAAGAREAVSAPVGGPGAGIAVGTG GP:U21717_1 2 2.612 0.335 A, G encoded by GenBank Accession AGSGGQ.S Number D14289; proto-oncogene homolog. N.AEDAVTQVKRQAVI.E 2 2.648 0.140 Human (c-myb) gene, complete primary cds, and five complete F.LVETGFLHVGQAGLELLTSGDLPASAS IPI:IPI00219499.1 GP:U22376_5 3 3.860 0.180 G alternatively spliced cds; alternatively QSARIT.G (95%) spliced product using exon 13A. Human B cell chronic lymphocytic leukemia immunoglobulin heavy chain GP:U22387_1 gene, VH1, JH4, Calpha1 regions, D.SGSYLYWGQGTLVTVSSASPTSPK.V 2 2.608 0.314 O, P partial cds; VH1, JH4, Calpha1 regions. S.YLYWGQGTLVTVSSASPTSPK.V 2 3.629 0.269 Human B cell chronic lymphocytic leukemia immunoglobulin heavy chain IPI:IPI00173849.1 GP:U22388_1 gene, VH3, DXP4, JH4, Calpha1 G.YYGYWGQGTLVTVSSASPTSPK.V 2 3.776 0.383 P (97%) regions, partial cds; VH3, DXP4, JH4, Calpha1 regions. Human B cell chronic lymphocytic leukemia immunoglobulin heavy chain GP:U22389_1 mRNA, VH3, JH4, Calpha1 regions, R.GLEWVSGIGAS.G 1 2.374 0.198 G partial cds; VH3, JH4, Calpha1 regions. 2 3.246 0.219 Human X2 box repressor mRNA, Q.KEPAQRELPPPREPPLHMEPISKKPPL GP:U22680_1 complete cds; XBR; zinc-finger 2 2.628 0.208 A RK.D protein. Mus musculus anti-human interferon- gamma receptor monoclonal antibody GP:U22902_1 G.ATSLETGVPSR.F 2 2.809 0.215 G gammaR38, IgG Vk region mRNA, partial cds. Human immunoglobulin kappa gene, GP:U26271_1 VJ region, partial cds, cell line HF- G.SNIAWYQQK.P 1 2.865 0.247 G, P 1.3.4(b1.1). 2 3.071 0.263 G.SNIAWYQQKPGQAPR.L 2 3.423 0.213 N.IAWYQQKPGQAPR.L 2 3.343 1.000 R.ASQSVGSNIAWYQQK.P 1 3.681 0.336 R.ASQSVGSNIAWYQQKPGQAPR.L 2 4.053 0.092 S.NIAWYQQK.P 1 2.544 0.233 S.NIAWYQQKPGQAPR.L 2 4.086 0.332 Human immunoglobulin kappa gene, GP:U26274_1 VJ region, partial cds, cell line HF- C.RASQSIGSNIAWYQQKPGQAPR.L 3 4.209 0.150 G 1.3.4(c1.2). R.ASQSIGSNIAWYQQK.P 2 2.275 0.229 Mustela putorius fibrinogen gamma A chain mRNA, partial cds; similar to GP:U28494_1 human fibrinogen gamma A chain, P.NGYDNGIIWATWQ.S 2 3.356 0.268 G, O Swiss-Prot Accession Number P02679. S.TPNGYDNGIIWATWQ.S 2 3.467 0.279 S.YSKSSTPNGYDNGI.I 1 2.219 0.099 T.PNGYDNGIIWATWQ.S 2 3.769 0.314 GP:U31368_1 Drosophila melanogaster schnurri K.ANIAAAIALA.A 1 1.838 0.097 G, O, P Supplementary Table 1 144 transcription factor (shn) mRNA, complete cds; similar to human PRDII/MBP1/HIV-EP1, Swiss-Prot Accession Number P15822. L.SNSSSELPSR.A 1 1.964 0.124 Y.KTAGKQYKTNKVNN.T 2 2.433 0.167 Human mercurial-insensitive water IPI:IPI00022799.1 GP:U34845_1 C.TRKISIAKSVFYIAAQCLGAIIGA.G 2 2.450 0.139 G, O channel mRNA, form 1, complete cds. (98%) I.YWVGPIIGAVLAGALYEY.V 2 2.937 0.120 Human anti-c-erbB-2 immunoglobulin GP:U36536_1 K.LLIYDNNKRPSGVPDR.F 2 2.525 0.103 G light chain V region mRNA, partial cds. Human anti-c-erbB-2 immunoglobulin A.EVKEPGQSLKISCKGFGYDFSTYWIAW GP:U36559_1 heavy chain V region mRNA, partial 3 3.776 0.222 A VRQMP.G cds. Human adducin gamma subunit IPI:IPI00220754.1 GP:U37122_1 mRNA, complete cds; putative M.PLSPLQIHGTRGNKREK.T 3 3.522 0.161 O (94%) spectrin-actin assembly factor. Xenopus laevis leucine zipper mRNA, complete cds; contains basic region GP:U37375_1 (bZip); similar to Homo sapiens R.EKRRAGDLALEGRVIALL.E 1 2.383 0.118 P E4BP4; one of two genomic copies, refers to pseudotetraploidy; gene 8. Human RNA binding motif (RBM) GP:U38455_1 K.SAPAVAR.S 1 1.834 0.115 A gene, partial cds; YRRM. Human IgG anti-platelet GPIIb/IIIa antibody heavy chain (ha4g1) mRNA, GP:U38663_1 D.PYFDYWGLGTLVTVSSASTK.G 2 2.849 0.185 G partial cds; anti-platelet GPIIb/IIIa antibody. R.DPYFDYWGLGTLVTVSSASTK.G 2 2.930 0.267 Caenorhabditis elegans cosmid C23G10, complete sequence; weakly similar to human RD protein; weak similarity to adenylyl cyclase- GP:U39851_6 I.NPLFLLAKDGNQE.A 2 3.162 0.104 A, G, O, P associated protein cap - S. Pombe (PIR:A60047); coded for by the following C. elegans cDNAs: yk26e11.3, yk26e11.5, yk28e1 Vulpes vulpes sperm surface protein fPH-20 mRNA, complete cds; GP:U41412_1 homolog of human PH-20, PIR G.EDVCIDVYLNLVPSGHLPVW.K 2 2.853 0.221 A Accession Number A48795; sperm surface protein PH-20. Caenorhabditis elegans cosmid R04A9, complete sequence; similar to homeobox proteins and to human centromeric protein E GP:U41550_4 Q.VRNYFNK.K 1 1.847 0.092 P (SP:CENE_HUMAN,Q02224) and to ribosomal protein S6 kinase; coded for by the following C. elegans cDNAs: yk740b11.5, yk724a4.5, yk7 Human Ets transcription factors NERF-1a and NERF-1b (NERF-1a,b) IPI:IPI00080461.1 GP:U43189_1 I.HAAMRPDVITETVVEVSTEE.S 2 3.466 0.081 P mRNA, complete cds; Ets transcription (96%) factor. Human kinase suppressor of ras-1 (KSR1) mRNA, partial cds; protein GP:U43586_1 kinase related to Raf protein kinases; S.NPSSATTPPNPSPGQRDSR.F 1 1.925 0.148 P Method: conceptual translation supplied by author.. Human putative transmembrane receptor IL-1Rrp mRNA, complete IPI:IPI00021999.1 GP:U43672_1 K.SSGSQEHVELNPRS.S 2 2.538 0.118 G cds; homolog of type I IL-1 receptor; (93%) putative transmembrane receptor. Human immunoglobulin light chain variable region mRNA, cell line 28e4, GP:U43766_1 V.SSNLAWYQQTPGQAPR.L 2 3.224 0.252 G anti-RhD, partial cds; Rhesus blood group antibody V region. Human immunoglobulin light chain variable region mRNA, cell line 19a5, IPI:IPI00030205.1 GP:U43771_1 E.VVLTQSPGTLSLSPGER.A 2 4.432 0.469 G, O, P anti-RhD, partial cds; Rhesus blood (93%) group antibody V region. G.EVVLTQSPGTL.S 2 2.674 0.234 G.EVVLTQSPGTLSLSPGER.A 1 2.685 0.104 2 4.656 0.487 Human immunoglobulin E heavy chain GP:U44499_1 -.EVQLEQSGAEVK.R 1 2.966 0.184 G, O, P VH32 (VH5) mRNA, partial cds; Supplementary Table 1 145 Description: VH32; IgE variable region. 2 3.894 0.259 Human Ig H-chain variable region (101-2H) mRNA, partial cds; Method: GP:U44793_1 C.EVLLVESGGGLVQPGGSLR.L 2 3.687 0.300 O conceptual translation supplied by author. Homo sapiens DNA-binding protein CPBP (CPBP) mRNA, partial cds; GP:U44975_1 core promoter binding protein; TATA A.TRPDMDVLPMCSIFQELQIVH.E 2 2.977 0.177 A box-less promoter binding protein; transcription factor. Rattus norvegicus chapsyn-110 mRNA, complete cds; channel IPI:IPI00019328.1 GP:U49049_1 associated protein of synapse-110; V.ILDGDSEEMGVIPSKRR.V 2 2.723 0.121 O (91%) similar to human PSD-95 encoded by GenBank Accession Number U32376. Human FRAP-related protein (FRP1) mRNA, complete cds; similar to IPI:IPI00178351.1 GP:U49844_1 E.DGHFYLAKYYDK.L 2 3.056 0.149 G, O, P FRAP, Mec1p, Tor1p, Tor2p, and (97%) ATM. M.EFNSLINK.C 1 1.861 0.098 Human T cell receptor V-alpha 22 GP:U50555_1 K.TGANSKLTFGKGITLSVRPD.- 2 2.731 0.112 P (TCRA) mRNA, partial cds. Homo sapiens X28 region near ALD locus containing dual specificity phosphatase 9 (DUSP9), ribosomal protein L18a (RPL18a), M.VSDFGLSKIQAGNMLGTACGTPGYVA. GP:U52111_3 2 2.483 0.140 G, P Ca2+/Calmodulin-dependent protein P kinase I (CAMKI), creatine transporter (CRTR), CDM protein (CDM), adrenoleukodystrophy protei R.LGSGAFSEVVLAQERGSAHLVALKCI.P 2 2.418 0.181 Saccharomyces cerevisiae Uso1p (USO1) gene, partial cds, Rad59p (RAD59) gene, complete cds; similar to the C. elegans F10G7.1 protein GP:U53668_3 D.VEWFKSIPLFTKSGR.S 2 2.594 0.084 O encoded by GenBank Accession Number U40029; similar to the human KIAA0187 protein encoded by GenBank Accession Numbe Human ser-thr protein kinase PK428 mRNA, complete cds; protein kinase IPI:IPI00217347.1 GP:U59305_1 R.NCEAPY.I 1 2.216 0.113 A related to the myotonic dystrophy (98%) protein kinase family. Human homolog of yeast UPF1 (HUPF1) mRNA, complete cds; putative Zn Knuckle; type 1 RNA IPI:IPI00220980.1 GP:U59323_1 L.LGHEVEDVITKCQLPKRFT.A 2 4.931 0.133 A, G, O, P helicase region; proline glycine rich (93%) region; serine glutamine rich region; similar to yeast Upf1. Human clone C-13-27 immunoglobulin heavy chain variable region (VH6- GP:U59332_1 R.ITIDPDTSK.N 1 2.419 0.148 G DXP4-J6) gene, partial cds; V-region; VH6 codons 21 to 106; mutated VH6. Human anaplastic lymphoma kinase V.HEWAGGGGGGGGATYVFKMKDGVPV IPI:IPI00178859.1 GP:U62540_1 (ALK) mRNA, complete cds; receptor 2 2.600 0.124 A P.L (93%) tyrosine kinase. V.HEWAGGGGGGGGATYVFKMKDGVPV 2 2.553 0.102 PLIIAAGGGGR.A Arabidopsis thaliana Ran binding protein 1 homolog (RanBP1) mRNA, GP:U62742_1 R.ENREDETEVNEDEDTGAQVAPIV.R 2 2.554 0.179 P complete cds; similar to human Ran binding protein 1. Human Ig heavy chain variable region GP:U63211_1 L.PQQRGDRALQQ.L 2 3.011 0.080 A, O (humha311) mRNA, partial cds. Human Ig Ig heavy chain variable GP:U63212_1 Q.AFGGTTDYAAPVR.G 2 2.876 0.224 G region (humha343) mRNA, partial cds. Human rheumatoid arthritis synovium GP:U64488_1 immunoglobulin heavy chain variable H.LAESGGGIVEPGGSLR.I 2 3.910 0.414 G region mRNA, partial cds. Human rheumatoid arthritis synovium GP:U64501_1 immunoglobulin heavy chain variable Q.LVESGGDLVKPGR.S 2 3.167 0.097 G, P region mRNA, partial cds. Mus musculus extracellular matrix GP:U64827_1 associated protein (Sc1) mRNA, Y.YLKYGGGEETTTGE.S 2 3.178 0.123 A complete cds; similar to to Mus Supplementary Table 1 146 musculus Sparc and human hevin; secreted glycoprotein. Human monoclonal antibody kappa GP:U66190_1 chain variable region mRNA, partial R.ASQSVSGSYLAWYQQKPGQAPR.L 2 2.778 0.261 G cds. Dictyostelium discoideum SapA (sapA) mRNA, partial cds; similar to GP:U66367_1 human proactivator polypeptide I.KIDVNINKCEI.C 1 2.732 0.180 G precursor saposin A region, Swiss- Prot Accession Number P07602. Human anaplastic lymphoma kinase IPI:IPI00178859.1 GP:U66559_1 receptor mRNA, complete cds; ALK R.AGSPAAGPPLQPRE.P 1 2.438 0.088 A (93%) receptor; tyrosine kinase receptor. Human zinc finger protein mRNA, IPI:IPI00004337.1 GP:U69274_1 F.LPLLEFAYTSVLSFDF.C 1 2.295 0.144 G complete cds. (93%) K.DWYSHVKSHSVTEPYRCNICG.K 2 2.902 0.146 Human clone ABD4-lam2VL anti-DNA GP:U70234_1 immunoglobulin light chain mRNA, R.VSWYQQSPGTAPK.V 2 4.052 0.362 G, O, P partial cds; rearranged variable region. Human clone ABD4-lam3VL anti-DNA IPI:IPI00179702.1 GP:U70235_1 immunoglobulin light chain mRNA, A.QAAELQPPSVSGAPGQR.V 2 3.287 0.283 G, O, P (95%) partial cds; rearranged variable region. Human clone AD4-18VL anti-DNA GP:U70237_1 immunoglobulin light chain mRNA, G.DNSRPSGVPDR.F 2 2.268 0.125 G, O partial cds; rearranged variable region. H.WYQQIPGTAPK.L 2 3.241 0.261 Caenorhabditis elegans CELF35-1 mRNA, complete cds; metabotropic glutamate receptor homolog; similar to GP:U70870_1 L.LILSPPPATSSTANISSLIEA.L 2 3.529 0.153 G human metabotropic glutamate receptor type 3 encoded by GenBank Accession Number X77748. Mesocricetus auratus pancreas cancer-associated protein 4 mRNA, GP:U73375_1 L.WLLVPGTQGTKDGDMRLVNGA.S 2 2.404 0.130 G complete cds; PCAP-4; similar to human Mac-2-BP and murin. W.YYPYQSFQTPQHPS.F 2 2.610 0.395 Human immunoglobulin H23 light chain kappa variable region (IgVK) GP:U73593_1 -.DLQMTQSPSSL.S 2 3.874 0.361 G, O, P mRNA, partial cds; recoginizes breast cancer associated antigen Muc-1. -.DLQMTQSPSSLSA.S 2 3.730 0.376 -.DLQMTQSPSSLSASVGDR.V 1 3.608 1.000 2 5.810 1.000 Homo sapiens clone BY-7LC IgM light GP:U76678_1 chain variable region mRNA, partial S.YELTQPPSVSVAPGK.T 2 3.726 0.432 G, O cds. Homo sapiens clone CDC-1LC IgM GP:U76680_1 light chain variable region mRNA, S.YELTQPPSVSVAPGKTAR.I 2 4.256 0.466 O partial cds. Human clone 54A10 immunoglobulin IPI:IPI00018563.3 GP:U77547_1 variable region (VH5-D-JH5) gene, -.EVQLVQSGAEAKR.P 2 2.776 0.208 O (96%) partial cds. Human clone 7A12 immunoglobulin IPI:IPI00018563.3 GP:U77560_1 variable region (VH5-D-JH3) gene, R.YSPSFQGQVTISADQ.S 2 3.168 0.477 G (98%) partial cds. Human transmembrane protein Jagged mRNA, partial cds; Notch IPI:IPI00099650.2 GP:U77720_1 D.KTPKLDK.Q 1 1.895 0.099 P ligand; similar to Jagged 1 encoded by (98%) GenBank Accession Number U61276. Human clone 23855 mRNA, partial IPI:IPI00167586.1 GP:U79302_1 R.LYGGAL.L 1 1.803 0.114 A cds. (96%) Human clone HA immunoglobulin GP:U79582_1 V.QAQVQLVQSGAEVK.K 2 4.919 0.271 G heavy chain gene, partial cds. Human clone SM immunoglobulin V- IPI:IPI00003485.1 GP:U79586_1 G.DIVLTQSPGTL.S 2 3.463 0.317 G, O, P region light chain mRNA, partial cds. (94%) G.DIVLTQSPGTLSLSPGER.A 1 2.241 0.105 2 4.927 0.477 Human clone OR immunoglobulin light IPI:IPI00003486.1 GP:U79588_1 R.ASQSVSSTYLAWYHQKPGQAPR.L 2 3.600 0.361 G chain gene, partial cds. (91%) Human clone SC immunoglobulin light GP:U79590_1 E.IVMTQSPATLSVSPGEGA.T 2 3.437 0.369 G, O chain mRNA, partial cds. G.EIVMTQSPATLSVSPGEGA.T 2 3.602 0.275 Human immunoglobulin heavy chain IPI:IPI00220120.1 GP:U80154_1 K.GLEWVSLISGSGGSTDYADSVK.G 2 3.305 0.174 O, P variable region (V3-23) gene, partial (93%) Supplementary Table 1 147 cds; Ig VH3 heavy chain. S.LISGSGGSTDYADSVK.G 2 2.445 0.125 V.YYCAKNIQPDYWGQG.T 2 2.612 0.095 Human immunoglobulin heavy chain GP:U80157_1 variable region (V3-30) gene, partial -.QVQLVESGGGVVQPGNSLK.L 1 2.618 0.083 G cds; Ig VH3 heavy chain. Xenopus laevis BMP type II receptor mRNA, complete cds; similar to human T-ALKr, BMPR-II and BRK-3; GP:U81958_1 authors indicate that sequence is K.ESRLKFSSKHKSN.L 1 2.619 0.170 G, P subject to final confirmation, entire sequence has not been checked on both strands. N.FTPSDPTSASPYSPTGW.L 1 2.002 0.093 Homo sapiens unknown protein GP:U82313_1 L.SMCESMLAVLSSNEINCPLPGSPVT.V 2 3.060 0.084 G mRNA, partial cds; novel ORF. Human anti-HIV-1 gp120 V3 loop GP:U82961_1 antibody DO142-10 heavy chain G.LFEHWGQGTLVTVSSASTK.G 2 2.686 0.167 G variable region mRNA, partial cds. Human anti-HIV-1 gp120 V3 loop GP:U82962_1 antibody DO142-10 light chain -.MAELTQSPDSLAVSLGER.A 2 4.604 0.414 G, O variable region mRNA, partial cds. K.NYLAWYR.Q 1 1.954 0.116 K.NYLAWYRQK.S 2 2.710 0.213 Mus musculus ROSA 26 transcription AS ROSA26AS mRNA, complete cds; The predicted amino acid sequence is similar to putative products of human GP:U83176_1 P.LKVWQINTTFKK.K 2 2.824 0.080 O ESTs and C. elegans m04b22; this mRNA is transcribed in the other orientation compared to those of transcrip V.RSESEHLQVTIGAT.V 2 2.578 0.169 Homo sapiens isolate LAN IgM heavy GP:U84178_1 chain VH1 region precursor (VH1-69) R.SEDTAVYYCASCG.S 2 2.546 0.199 G gene, partial cds; Allele: variants 1,5. Homo sapiens isolate MAR IgM heavy GP:U84184_1 chain VH1 region precursor (VH1-69) T.IIPILGTANYVQK.F 2 2.838 0.126 G gene, partial cds; Allele: variants 1,5. Human IgM rheumatoid factor RF- GP:U85232_1 FO2, variable heavy chain, mRNA, -.EVQLVESGGGLSQPGGSLR.L 2 3.473 0.083 G partial cds. Human telomerase-associated protein F.LCASSDGILWNLAKCSPEGEWTTGNM. IPI:IPI00158614.1 GP:U86136_1 2 2.509 0.169 O, P TP-1 mRNA, complete cds. W (96%) K.IPPPPGKTGV.Q 1 1.835 0.113 P.SGRSVTEMEVMQFLNRNQRL.Q 2 2.614 0.114 Q.HTYPKSLNCVAFHPEGQVIATGSWA.G 3 3.861 0.170 Human rearranged IgH variable region IPI:IPI00161117.1 GP:U86363_1 I.DTSKNQFSLNLTSVIAADTAVYYC.A 2 3.014 0.152 G gene, partial cds. (93%) Human rearranged IgH variable region GP:U86370_1 R.DTSASTADMELSSLRSEDPAVY.Y 2 2.550 0.098 A gene, partial cds. Human immunoglobulin lambda light chain V region (Humla448) mRNA, IPI:IPI00017248.1 GP:U86671_1 D.TSGNHLVFGGGTK.L 1 1.911 0.219 G partial cds; GG48 IgG rheumatoid (94%) factor. Homo sapiens cell-type B cells Ig GP:U86789_1 heavy chain variable domain (CLL- F.SLTTSGVGVGWIR.Q 2 3.155 0.346 G H3B) mRNA, partial cds; rearranged. Human Ig lambda chain V-region (VL- IPI:IPI00166489.1 GP:U86805_1 Q.SVLTQPPSVSVAPGKTAR.I 2 3.555 0.446 O HUC) mRNA, partial cds; rearranged. (91%) Human immunoglobulin light chain V GP:U87151_1 C.SSYAGSNNWVFGGGTNL.T 2 2.824 0.152 P region mRNA, partial cds. Mus musculus strain BALB/c transcription factor E4BP4 mRNA, partial cds; similar to human GP:U89411_1 transcriptional repressor E4BP4, PIR I.KQEPVELESFA.R 1 2.299 0.080 A Accession Number S18995; belongs to CREB-ATF subfamily of bZIP family of transcription factors. S.HSQALLQVHGSTSNSPRISEDDEGAVV 2 2.299 0.150 K.S Human prolyl 4-hydroxylase alpha (II) IPI:IPI00182373.1 GP:U90441_1 E.ATTTKSQVLDY.L 1 2.203 0.132 G subunit mRNA, complete cds. (97%) 2 2.705 0.152 GP:U90920_1 Human PTPL1-associated RhoGAP K.MNSKNLGVIFGPSLIR.P 2 2.566 0.176 P IPI:IPI00152011.1 Supplementary Table 1 148 mRNA, complete cds; PARG. (93%) Human cardiac myosin binding IPI:IPI00000950.1 GP:U91629_1 protein-C (MyBP-C) gene, complete K.EGQPLAGE.E 1 1.874 0.151 A, G, O (93%) cds. S.GGQALAELIVQEKKLEVYQSI.A 3 3.992 0.108 V.EVAAGSPAVF.E 1 2.166 0.087 Human retina-derived POU-domain IPI:IPI00220088.1 GP:U91934_1 I.QGLVAAAAAGGI.M 1 2.059 0.090 O factor-1 mRNA, complete cds. (91%) L.TLPTANLTNIQGLVAAAAAGGIMT.L 2 2.527 0.178 Human clone B12-2 immunoglobulin GP:U95238_1 rearranged heavy chain mRNA, partial -.EVLLVESGGGLVKPGGSLR.L 2 3.235 0.120 G, O cds; VDJ region. Human clone B5-3 immunoglobulin IPI:IPI00003486.1 GP:U95243_1 rearranged light chain mRNA, partial -.ETVLTQSPGTLSLSPGER.A 2 4.511 0.332 G, O, P (92%) cds; VJ region. Homo sapiens Ig kappa light chain GP:U96292_1 variable region (VkII-A17) mRNA, S.SSQSLVYSDGDTYLNWFQQR.P 2 4.787 0.456 P partial cds. Homo sapiens Ig kappa light chain IPI:IPI00003457.1 GP:U96294_1 variable region (VkI-L15) mRNA, K.PGKAPKSLIYK.A 2 3.007 0.123 G (95%) partial cds. Homo sapiens IgM heavy chain IPI:IPI00220120.1 GP:U97242_1 variable region (humha316) mRNA, G.GEYWGQGTLVTVSSASTK.G 2 2.550 0.232 G (95%) partial cds. G.GGEYWGQGTLVTVSSASTK.G 2 3.430 0.201 Homo sapiens IgM heavy chain IPI:IPI00053682.1 GP:U97250_1 variable region (humka116) mRNA, -.DIQMTQCPSSL.S 2 2.898 0.116 G, P (94%) partial cds. -.DIQMTQCPSSLSA.S 2 3.063 0.156 Homo sapiens IgM heavy chain IPI:IPI00026195.1 GP:U97251_1 variable region (humka227) mRNA, R.VEAEDVGVYYCMQGTHWPFTF.G 2 2.877 0.286 G (96%) partial cds. Homo sapiens butyrophilin (BT3.3) IPI:IPI00019737.1 GP:U97502_1 E.SSSDTKKSALMLK.W 2 2.801 0.092 P gene, exon 10, and complete cds. (98%) Human messenger RNA for serum IPI:IPI00022434.1 GP:V00494_1 K.KVPEVSTPTLVEV.S 2 3.114 0.364 A, G, O, P albumin (HSA); reading frame HSA. (99%) K.KVPEVSTPTLVEVS.R 1 2.887 0.180 2 3.587 0.237 K.KVPEVSTPTLVEVSR.N 1 3.601 0.345 2 3.983 0.352 3 4.865 0.336 K.KVPEVSTPTLVEVSRNLGK.V 2 2.598 0.325 K.VPEVSTPTLVEVS.R 2 3.557 0.271 K.VPEVSTPTLVEVSR.N 1 2.814 0.330 2 3.521 0.295 R.YTKKVPEVSTPTLVEVS.R 2 2.635 0.336 R.YTKKVPEVSTPTLVEVSR.N 2 4.023 0.394 3 5.066 0.373 R.YTKKVPEVSTPTLVEVSRNLGK.V 3 4.234 0.415 T.KKVPEVSTPTLVEVSR.N 2 2.677 0.323 V.PEVSTPTLVEVSR.N 2 2.778 0.243 Y.KFQNALLVRYTKKVPEVSTPTLVEVSR. 3 4.325 0.280 N Yeast YP2 gene The YP2 protein shows homology with the p21 proteins encoded by the human c-has/bas proto-oncogenes and transforming GP:X00209_2 R.GSHGIIIVYDVTDQESFNGVKM.W 2 2.625 0.107 G p21 proteins of the Harvey (v-rasH) and Kirsten (v-rasK) murine sarcoma viral oncogenes; coding sequence YP2 gene. Human haptoglobin related (Hpr) gene IPI:IPI00019572.1 GP:X01794_1 K.VVLHPNYHQVDIGIIK.L 2 4.210 0.382 O, P exon 1, and joined CDS. (99%) 3 4.569 0.393 Human mRNA for Leu-8 pan IPI:IPI00218795.1 GP:X17519_1 S.FSMIKEGDFLTLVFSF.N 2 3.293 0.085 P leukocyte antigen. (95%) Human mRNA for serum amyloid A IPI:IPI00022368.1 GP:X51445_1 R.LTGHGAEDSLADQAANK.W 2 5.527 0.532 A, O, P (SAA) protein partial, clone pAS8. (92%) 3 3.776 0.215 Human mRNA for fibrinogen gamma GP:X51473_1 R.KMLEEIMK.Y 1 2.744 0.127 O, P chain (partial). 2 3.139 0.167 Supplementary Table 1 149 R.KMLEEIMKYEASILTHDSSIR.Y 2 5.306 0.451 3 6.294 0.416 Human V108 gene encoding an immunoglobulin kappa orphon; GP:X51887_1 immunoglobulin kappa orphon (AA I.SNGLSWYQQKPGQ.A 2 2.632 0.130 G 95); Protein sequence is in conflict with the conceptual translation. Human rearranged immunoglobulin IPI:IPI00003486.1 GP:X54840_1 kappa III light chain V-segment S.PTLTFGGGTK.V 1 1.940 0.133 G (91%) mRNA. Human rearranged immunoglobulin IPI:IPI00030206.1 GP:X54841_1 kappa III light chain V-segment R.ASQSVSSDYLAWYQQK.P 2 2.268 0.341 G (95%) mRNA. R.ASQSVSSDYLAWYQQKPGQAPR.L 2 4.048 0.223 S.SDYLAWYQQKPGQAPR.L 2 2.699 1.000 Human immunodeficiency type 1 GP:X57450_1 (isolate J91) gene for env (partial); L.LLSGIVQQQNNL.L 2 2.658 0.094 O partial. Homo sapiens partial mRNA for IPI:IPI00019439.1 GP:X62009_1 A.HNCDMHASCLNIPGSFK.C 2 2.418 0.235 A fibrillin 5. (98%) A.LMPDGRSCADIDECENNPDI.C 2 2.669 0.098 O.volvulus mRNA for ankyrin GP:X84359_1 homologue; homologue to human L.FDGAETSANEARS.D 2 2.670 0.200 A, G ankyrin. N.ILPITKSGDQLSL.Y 2 3.631 0.144 Homo sapiens mRNA for partial IPI:IPI00164586.1 GP:X87832_1 R.ALAHQLGLAEDEDVLF.T 1 2.080 0.165 A NOV/plexin-A1 protein. (95%) V.RAHDALVEVCVRDCSPHYR.A 2 2.237 0.142 Homo sapiens mRNA for immunoglobulin lambda chain variable GP:X91131_1 region (cell line LJ1); phospholipid- K.NVHWYQQKPGQAPVLVIYD.D 2 3.853 0.288 G, O binding, Beta2-glycoprotein 1 independent MAb. K.PGQAPVLVIYDDSDRPSGIPER.F 2 4.655 0.382 3 4.454 0.418 Homo sapiens mRNA for immunoglobulin lambda chain variable IPI:IPI00179702.1 GP:X91133_1 region (cell line DA3); phospholipid- -.XSVLTQPPSVSGAPGQR.V 1 2.021 0.193 G, O (96%) binding, Beta2-glycoprotein 1 independent MAb. 2 3.371 0.399 Homo sapiens mRNA for GP:Y14861_1 immunoglobulin kappa light chain, C.DIQMTQSPTSLSA.S 2 3.454 0.233 G, O, P clone VkLaE03. C.DIQMTQSPTSLSASVGDR.V 1 3.155 0.106 2 4.427 0.242 3 3.519 0.159 Homo sapiens mRNA for IPI:IPI00093751.3 GP:Y14863_1 immunoglobulin kappa light chain, C.DIQMTQSPF.S 2 2.764 0.123 G (94%) clone VkLaE25. C.DIQMTQSPFSLSA.S 2 2.623 0.214 Homo sapiens mRNA for GP:Y14867_1 immunoglobulin kappa light chain, L.LYFVSRLEPGVPSRFSGGGSGT.E 2 3.022 0.167 A clone VkLaV19. Homo sapiens mRNA for IPI:IPI00093751.3 GP:Y14870_1 immunoglobulin kappa light chain, L.LLYAASTLQSGVPSR.F 2 3.326 0.310 O (91%) clone VkLaV87. Homo sapiens mRNA for GP:Y14871_1 immunoglobulin kappa light chain, R.FSGSGSGTDYTLI.I 1 2.324 0.119 G clone VkLaV88. Homo sapiens mRNA for GP:Y17933_1 R.VTISLDTSQ.N 1 2.199 1.000 G immunoglobulin heavy chain, JK47H. Homo sapiens mRNA for IPI:IPI00181894.1 GP:Y17950_1 K.YNSALKTFGQGTK.V 2 3.087 0.304 G immunoglobulin light chain, KC3L. (95%) Homo sapiens SALL1 gene, exon 1 GP:Y18264_1 D.CGPAGSATTFTNPLLPLMSEQFKA.K 2 3.033 0.148 P and joined CDS. D.melanogaster for Dpbx gene; A.EGVAGPEKGGGGAAAASAAAASQGG IPI:IPI00215867.1 GP:Z18864_1 D.melanogaster homolog of the 3 3.780 0.181 A SLSIDG.A (94%) human pbx gene family. S.pombe chromosome I cosmid c22F3; SPAC22F3.14c, len:1621, GP:Z54285_1 SIMILARITY:Homo sapiens, O75984, F.LNNLSNANGIFNFDERFTNT.K 2 2.602 0.123 P hypothetical 127.6 kd protein, (1114 aa), fasta scores: opt: 1461, E():0, Supplementary Table 1 150 (30.4% identity in 1083 aa). K.EDDENLESYFMMVALLIKYNFISIDNIW 3 3.512 0.196 A.H Caenorhabditis elegans cosmid C27A7, complete sequence; Similarity GP:Z81041_3 to Human plasma-cell membrane K.TDEYLKHYGKLFVLSG.L 1 2.206 0.088 G glycoprotein PC-1 (SW:P22413), contains similarity to Pfa. Human DNA sequence from clone RP3-370M22 on chromosome 22 Contains part of the gene for ubiquinol-cytochrome c reductase IPI:IPI00182020.1 GP:Z82206_1 E.STEARKGFSYLVTGVTTVGVAYAAK.N 2 2.988 0.098 P iron-sulfur subunit precursor (96%) (UQCRFS1) like protein, part of the gene for EPSIN 2B, the GRAP2 (GRB2-related adaptor protein 2) g Human DNA sequence from PAC 75N13 on chromosome Xq21.1. Contains ZNF6 like gene, ESTs, STSs and CpG islands; match: multiple IPI:IPI00215741.1 GP:Z82216_1 proteins; match: P17011 P17012 L.PEIQLEDSDVNK.T 2 2.641 0.120 O (97%) P23607 P08048 P31508; match: Q01611 P20662 P10925 Q91940 P17010; match: Q90232 Q03923 Q29419 Q Human DNA sequence from clone RP1-46H23 on chromosome 13. Contains the 3' end of the KL gene for klotho, the 3' end of the gene for a IPI:IPI00216573.1 GP:Z84483_2 K.FMKRMKVPDYK.D 1 2.615 0.106 O, P novel RhoGAP domain protein, ESTs, (93%) STSs and GSSs, complete sequence; match: proteins: Tr:Q9R0Z9 Tr:Q63744 Tr:O14868 Human DNA sequence from clone LA16-367G8 on chromosome 16. Contains the gene for melanoma antigen P15, a novel gene, the gene IPI:IPI00013157.1 GP:Z97634_3 E.AEAKAKALKAKKAA.L 2 2.827 0.143 O, P for a novel protein similar to RPL23A (96%) (60S ribosomal protein L23A) and the NME4 gene for a protein expressed in non-metastat Human DNA sequence from clone RP1-54B20 on chromosome Xp11.1- 11.3. Contains the 5' end of a novel SSX family protein gene, two novel GP:Z98304_3 K.FDSCENSLKSNSDLLNYN.R 2 2.542 0.108 P KRAB box containing C2H2 type zinc finger protein genes, a KRAB box protein pseudogene, the gene for a novel protein Q.KSLLIIHLR.V 2 2.554 0.101 Human DNA sequence from clone RP1-54B20 on chromosome Xp11.1- 11.3. Contains the 5' end of a novel SSX family protein gene, two novel GP:Z98304_5 C.GKSFNEKSTLIVHQRTHT.G 2 3.105 0.161 A, G KRAB box containing C2H2 type zinc finger protein genes, a KRAB box protein pseudogene, the gene for a novel protein L.FSRSSAENKYDNGCAK.L 2 2.687 0.216 L.IIHQRTHTGEKPHKCTECGK.S 2 2.722 0.111 Homo sapiens pp12708 mRNA, GPN:AF318327_1 K.NLQSKHLDVKIL.K 1 2.356 0.085 A complete cds. Homo sapiens pp9320 mRNA, R.SEDKARWHLTLLLVLEDRLHRQLTYDL. IPI:IPI00168489.1 GPN:AF318376_1 3 3.783 0.203 P complete cds. L (92%) Homo sapiens voltage-dependent GPN:AF361354_1 calcium channel gamma-8 subunit P.RHPAPSAPAPGTLAKGA.A 2 3.101 0.114 O (CACNG8) mRNA, complete cds. Homo sapiens haplotype J2 GPN:AF382001_6 L.PAAVLIILFPPLLIPTSKCLINNRL.I 3 4.111 0.134 G mitochondrion, complete genome. Homo sapiens NUANCE (NUA) mRNA, complete cds; actin-binding IPI:IPI00103541.1 GPN:AF435011_1 I.YNLKDRLTAIKCCILQVLKLKKV.F 2 2.447 0.198 A, O protein associated with nuclear (95%) envelope. K.ENEEFTGQLKVAK.D 1 1.948 0.129 N.KIQILNNWMEAQEER.L 2 2.662 0.112 Q.AELQMKR.I 1 1.857 0.093 Supplementary Table 1 151 S.FMESFNEEKKSF.L 2 2.919 0.155 V.KHRKKSLIRLDKVLDEYEEEK.R 2 2.254 0.130 Homo sapiens B-motin mRNA, partial IPI:IPI00186093.1 GPN:AF453742_1 F.KVGGGPSPAQPAGKVLDPR.G 2 2.207 0.182 G, O, P cds. (93%) L.PFPSTMQQHSPMSSQTSSASGPL.H 2 2.786 0.096 Homo sapiens partial IGKV gene for GPN:AJ426187_1 immunoglobulin kappa light chain R.SSQSLLHR.N 1 2.156 0.148 G variable region, isolate VKPB4P. Homo sapiens IGKV gene for IPI:IPI00026197.1 GPN:AJ426226_1 immunoglobulin kappa light chain K.SSQSVLYSSNNQ.N 1 2.908 0.310 G (97%) variable region, isolate VKPGP4. 2 3.359 0.240 Homo sapiens IGKV gene for GPN:AJ426230_1 immunoglobulin kappa light chain A.GSTLQSGVPSR.F 2 2.750 0.186 G, O variable region, isolate VKPGP8. R.PSQSVSRFLNWYQQKPGK.A 2 3.156 0.185 V.LIYAGSTLQSGVPSR.F 2 2.762 0.151 Y.AGSTLQSGVPSR.F 2 2.328 0.224 Homo sapiens IGKV gene for GPN:AJ426233_1 immunoglobulin kappa light chain R.ASQTLTSTYLAWYQQK.P 2 2.895 0.171 G variable region, isolate VKPGP11. Homo sapiens IGKV gene for GPN:AJ426240_1 immunoglobulin kappa light chain N.NNYLAWYQQKPGQPPK.L 2 3.446 0.362 G variable region, isolate VKPGP18. Homo sapiens IGKV gene for GPN:AJ426262_1 immunoglobulin kappa light chain P.SLLIYDASNLESGVPSR.F 1 2.300 0.165 O variable region, isolate VKPGP40. Homo sapiens IGKV gene for GPN:AJ426263_1 immunoglobulin kappa light chain R.FSGSGSGADFTLTISR.L 2 2.578 0.294 G, O, P variable region, isolate VKPGP41. R.LLLYGASTR.A 2 2.991 0.235 Homo sapiens IGLV gene for GPN:AJ426381_1 immunoglobulin lambda light chain K.SGTSASLVISGLR.S 2 2.815 0.252 G variable region, isolate VLPG3P. Homo sapiens GCLL111 GPN:AY043093_1 immunoglobulin light chain variable R.DDLGWYQQK.P 2 2.715 0.244 G region mRNA, partial cds. R.DDLGWYQQKPGK.A 2 3.585 0.239 Homo sapiens GCLL128 GPN:AY043095_1 immunoglobulin light chain variable -.EIVLTQSPGSLSLSPGER.A 2 4.277 0.391 G, O region mRNA, partial cds. Homo sapiens GCLL186 IPI:IPI00003486.1 GPN:AY043099_1 immunoglobulin light chain variable -.EIVLTQSPGTLSLSPGDR.A 2 4.626 0.460 G, O, P (93%) region mRNA, partial cds. Homo sapiens MCLL019 GPN:AY043109_1 immunoglobulin light chain variable Y.GATTLQSGVPSR.F 2 3.696 0.265 G region mRNA, partial cds. Homo sapiens MCLL021 GPN:AY043111_1 immunoglobulin light chain variable -.DIVMTKTPL.S 1 2.194 0.124 G, P region mRNA, partial cds. R.SSQSLVHSDGNTYLSWLHQR.P 2 4.454 0.397 R.SSQSLVHSDGNTYLSWLHQRPGQPPR 3 3.701 0.231 .L Homo sapiens MCLL025 GPN:AY043113_1 immunoglobulin light chain variable K.LFIYDNNKR.P 2 2.514 0.118 G region mRNA, partial cds. Homo sapiens MCLL048 GPN:AY043121_1 immunoglobulin light chain variable K.RLISVASTLLSGV.P 2 2.715 0.126 G, P region mRNA, partial cds. S.YPHTFGQGTK.A 1 1.821 0.229 Homo sapiens MCLL087 GPN:AY043137_1 immunoglobulin light chain variable -.DIQMTQSPLSLSA.S 2 2.796 0.283 G, P region mRNA, partial cds. -.DIQMTQSPLSLSASVGDR.V 2 3.789 0.348 Homo sapiens MCLL088 IPI:IPI00181894.1 GPN:AY043138_1 immunoglobulin light chain variable -.DIQMTQSPASLSASVGDR.V 2 4.762 0.464 G, O (91%) region mRNA, partial cds. G.NYLAWYQQKPGKPPK.L 1 3.119 0.312 2 3.877 0.472 R.ASQGIGNYLAWYQ.Q 2 3.462 0.243 R.ASQGIGNYLAWYQQK.P 2 2.491 0.226 Homo sapiens MCLL093 GPN:AY043139_1 immunoglobulin light chain variable K.YDSAPLTFGGGTK.V 2 3.406 0.342 G region mRNA, partial cds. Supplementary Table 1 152 Homo sapiens MCLL094 IPI:IPI00024136.1 GPN:AY043140_1 immunoglobulin light chain variable -.EIVLTQSPVTLSLSPGER.A 1 2.435 0.319 G, O, P (95%) region mRNA, partial cds. 2 4.789 0.408 Homo sapiens MCLL108 IPI:IPI00003457.1 GPN:AY043144_1 immunoglobulin light chain variable K.APDLLIYK.A 1 2.499 0.103 G (94%) region mRNA, partial cds. Homo sapiens MCLL121 IPI:IPI00026197.1 GPN:AY043149_1 immunoglobulin light chain variable K.SSQSVLYSSNKN.N 1 2.121 0.194 G, O, P (94%) region mRNA, partial cds. 2 3.396 0.348 Homo sapiens MCLL125 GPN:AY043152_1 immunoglobulin light chain variable R.FSGSGAGTDFTLE.I 1 2.345 0.199 G region mRNA, partial cds. Homo sapiens MCLL136 GPN:AY043157_1 immunoglobulin light chain variable -.SSELTQDPAVSVALGQTAR.I 2 2.778 0.109 G, O region mRNA, partial cds. S.SELTQDPAVSVALGQTAR.I 2 3.354 0.290 Homo sapiens MCLL153 GPN:AY043163_1 immunoglobulin light chain variable G.VSNLESGVPSR.F 2 2.958 0.230 G region mRNA, partial cds. Homo sapiens, Similar to immunoglobulin heavy constant IPI:IPI00217045.1 GPN:BC019337_1 gamma 3 (G3m marker), clone Q.GTQVTVSSASTK.G 2 3.028 0.203 G (96%) MGC:12853 IMAGE:4054679, mRNA, complete cds. Homo sapiens, clone IPI:IPI00179332.1 GPN:BC019562_1 R.QEDDKLFLKINGSSNQ.E 1 2.462 0.082 G IMAGE:3451144, mRNA, partial cds. (99%) Homo sapiens, clone GPN:BC019679_1 R.GEIIDPFVEVEIIGLPVDCSREQ.T 2 2.523 0.149 A IMAGE:4932488, mRNA, partial cds. Homo sapiens, clone MGC:29977 GPN:BC019852_1 IMAGE:5123884, mRNA, complete R.EMPSALSILLLGVAYFK.G 2 2.672 0.178 O cds. Homo sapiens, clone MGC:29981 K.RLEKELGSPPGISLETIDAAFSCPGSSR GPN:BC019901_1 IMAGE:5123914, mRNA, complete 2 2.561 0.124 A, P LYVS.S cds. R.YYCFQGNKFLR.F 2 3.277 0.359 Homo sapiens, clone MGC:29964 GPN:BC019908_1 IMAGE:5123631, mRNA, complete K.NFNYLKSYLLEK.I 2 2.844 0.109 A cds. Caenorhabditis elegans cosmid T19D12, complete sequence; similar to A. faecalis poly(3-hydroxybutyrate) depolymerase (SP:PHB_ALCFA, F.SFTGDTQQVADQIGLKMASSNPSVYCP GPN:U41263_10 3 4.021 0.302 A, O P12625); similar to zinc finger protein PPVPSTAA.P 40 (SP:ZEP1_HUMAN, P15822); coded for by the following C. elegans cDNAs: cm9b6 N.IKTNGSQSVANFLSNTLLK.N 2 2.363 0.125 PIR1:A2HU Ig alpha-2 chain C region - human K.BVLVR.W 1 1.861 0.082 A, O, P K.SGBTFRPEVH.L 1 1.923 0.260 2 2.717 0.284 K.SGBTFRPEVHLLPPPSEELALBZLVTLT 3 4.078 0.281 CLAR.G IPI:IPI00002292.1 PIR1:A40701 tenascin-X precursor - human R.GEERQVTVGGLEPGRKYKMHLYG.L 2 2.742 0.179 G (99%) natural killer cell tumor-recognition PIR1:A47328 Q.VTQESKEKKVSENNETI.K 2 2.658 0.084 P protein - human R.DWSKSDKDVQSSLTHSSR.D 2 2.388 0.123 PIR1:A56539 giantin - human E.ITKENLAQAVEHRKKAQAELASF.K 2 2.543 0.171 A, O S.EDASALQGGTSVAQIKAQL.K 2 3.073 0.083 collagen alpha 1(V) chain precursor - PIR1:CGHU1V P.GEPGPRGLLGPKGPPGPPGPPGV.T 2 2.426 0.322 A, O human R.GFPGDRGLPGPVGALGLK.G 2 2.398 0.258 phosphoinositide-specific IPI:IPI00006660.1 PIR1:I54390 phospholipase C (EC 3.1.4.-) epsilon - R.SLEAIEEKESSE.E 2 3.020 0.111 G (93%) human plasma hyaluronan-binding protein IPI:IPI00041065.2 PIR1:JC4795 I.SGWGVTETGK.G 1 1.933 0.235 A, O, P precursor - human (98%) K.KEEFHEQSFR.V 2 2.902 0.266 K.VVLGDQDLKKEEFHEQSFRVEK.I 3 3.776 0.260 K.YSHYNERDEIPHNDIALLK.L 3 4.669 0.314 L.LMALVGK.T 1 2.052 0.088
Supplementary Table 1 153 kininogen, LMW precursor [validated] - IPI:IPI00215894.1 PIR1:KGHUL1 I.GEIKEETTSHLR.S 2 3.114 0.332 O, P human (97%) 3 3.502 0.299 K.AGAEPASEREVS.- 2 2.870 0.198 K.EETTSHLR.S 2 2.317 0.166 R.IGEIKEETTSHL.R 2 2.568 0.216 R.IGEIKEETTSHLR.S 1 2.714 0.236 2 4.100 0.293 3 4.762 0.359 IPI:IPI00220327.1 PIR1:KRHU2 keratin 1, type II, cytoskeletal - human G.AGGGFGSRSLAGSGGSIASIS.G 2 3.178 0.113 G, O, P (98%) R.EREQIQSLNNQF.A 2 3.243 0.155 R.GSYGSGGGSYGSGGSSYGSGGGGG 2 3.389 0.340 GHGSYGSGSSSGGYR.G Ig kappa chain V-IV region (Dep) - PIR2:A34153 -.DIVMTQSPESL.A 2 3.185 0.239 G, O human -.DIVMTQSPESLAVSLGER.A 2 4.456 0.231 adhesion-type protein ADMLX - IPI:IPI00177018.1 PIR2:A40351 G.IHPSEDHATHWQTVAQTTDER.V 2 2.610 0.085 G, P human (92%) V.DNECSGVKK.C 1 1.954 0.092 IPI:IPI00015028.1 PIR2:A40970 undulin 1 - human (fragment) E.TTSSLRVKWDISDSDVQQFRVTY.M 2 2.868 0.120 G (97%) kinase-related transforming protein PIR2:A41253 L.LIISNTAKHFYGQR.P 2 2.545 0.095 P (EC 2.7.1.-) - human Ig heavy chain precursor V-IV region PIR2:A41287 R.VTLSADTSK.N 1 1.962 0.278 G (120-16) (anti-HIV-1) - human nuclear mitotic apparatus protein IPI:IPI00180458.1 PIR2:A42184 L.RGLEAAQIKELEELRQTVKQL.K 2 3.005 0.103 A NuMA - human (96%) trithorax homolog HTX, version 2 - PIR2:A44265 K.MENESQSKNALKESVLLPFANRVNIS.T 2 3.084 0.084 O human Mac-2-binding glycoprotein precursor - IPI:IPI00181295.1 PIR2:A47161 K.AVDTWSWGER.A 2 2.671 0.325 G, O, P human (98%) K.SQLVYQSR.R 2 2.648 0.225 K.TLQALEFHTVPFQLLAR.Y 2 3.253 0.293 K.YSSDYFQAPSDYR.Y 2 3.860 0.369 R.ASHEEVEGLVEK.I 1 3.064 0.230 2 2.543 0.337 R.IYTSPTWSAFVTDSSWSAR.K 2 2.661 0.387 Ig kappa chain precursor V region - S.LLLWISGAAGDIVMTQSPDSLAVSLGE PIR2:A49137 3 3.577 0.250 O human R.A inositol 1,4,5-triphosphate receptor, IPI:IPI00032415.2 PIR2:A49873 R.LKPLVQAELSV.L 1 1.966 0.098 G type 3 - human (96%) centrosome autoantigen PCM-1 - IPI:IPI00001654.1 PIR2:A54103 I.LEDHGSPAGEIDDEDKDKDET.E 2 3.190 0.177 A human (92%) IPI:IPI00220343.1 PIR2:A54261 olfactory marker protein - human T.RQMRLRVERLK.Q 2 2.587 0.177 O (98%) inositol 1,4,5-triphosphate receptor IPI:IPI00218660.1 PIR2:A55713 G.PGKPGGGGGGSGSSSMSR.G 2 2.693 0.185 G, P type 1 - human (95%) R.ISCLLCIFKR.E 1 1.908 0.090 similar to ch-TOG protein from Homo PIR2:A84771 sapiens [imported] - Arabidopsis C.LTGRKNTVDK.A 2 2.666 0.165 G, P thaliana K.GFLNDVKPALLSALDTEYEK.N 2 2.399 0.103 K.PGGGKKDGSVRNEGSKS.V 2 2.548 0.095 Ig kappa chain V-I region (Wil[1]) - PIR2:B27585 K.APNLLIYQ.A 1 2.124 0.098 G human PIR2:B28096 line-1 protein ORF2 - human L.FNIVLEFL.A 1 2.209 0.091 G 93 (0%) Y.KPLLKEIKEDTKK.W 1 2.116 0.101 Ig kappa chain V-III region (She) - PIR2:B30609 -.EIVMTQSPGTLSVSPGER.A 2 5.017 0.455 G, O, P human (fragment) Ig kappa chain V-IV region (Fue) - PIR2:B34153 -.DIVMTQSPDSLAVSLGETA.T 2 2.824 0.285 O human probable RNA helicase 2 - human IPI:IPI00177366.1 PIR2:B56236 K.FQIYPDNFPLLTIPGRTHP.V 2 2.973 0.085 O (fragment) (94%) Ig heavy chain V region precursor PIR2:B56701 N.SYTFHWVR.Q 2 2.605 0.232 G (HuA) - human (fragment) Ig alpha-2 chain C region (allotype A.AEDWKKGETFSCMVGHEALPLAFTQK. IPI:IPI00004641.1 PIR2:C22360 3 4.053 0.231 P A2m(2)) - human (fragment) T (97%) voltage-dependent calcium channel PIR2:C44461 A.ALRRSPAPVSNLQGPYLA.S 1 2.080 0.197 A beta subunit beta1B2 isoform - human Ig heavy chain V-V region (Ab2022) - PIR2:D34964 Q.GQVTLSADK.S 1 1.959 0.253 G human Supplementary Table 1 154 Ig kappa chain V-IV region (DEP) - PIR2:D61458 -.DIVMTESPESL.A 2 4.052 0.171 G human (fragment) PIR2:G02493 KR-ZNF1 - human (fragment) A.KPYKCKVCDKAFAWNSHLVSHT.S 2 3.221 0.109 G adenylate cyclase (EC 4.6.1.1) - PIR2:I37136 I.LFVCFAGQLLQCSKKASPLLM.W 2 2.465 0.138 A, P human (fragment) W.LLKSSGIIANQP.W 2 2.523 0.136 IPI:IPI00003062.1 PIR2:I38171 hugl protein - human C.SAHVASVPAK.L 1 1.973 0.134 P (91%) receptor tyrosine kinase - human IPI:IPI00030887.1 PIR2:I38412 A.EIYNYLIGGNLKQ.P 2 3.050 0.085 A (fragment) (94%) Ig kappa chain (BRE) - human PIR2:I39154 K.APNLLIYDASTLETGVPSR.F 2 2.419 0.186 G, O, P (fragment) N.LLIYDASTLETGVPSR.F 2 3.100 0.422 IPI:IPI00026059.1 PIR2:I59291 beta1-syntrophin - human Y.ENGFSITTEPQEG.A 2 2.918 0.210 A (91%) epithelial sodium channel gamma C.PEAPRSPQGQDNPALDIDDDLPTFNSA IPI:IPI00016450.1 PIR2:I64847 3 4.359 0.172 O subunit - human LHLPPSL.G (91%) hippocampal 38K autoantigen protein IPI:IPI00140449.1 PIR2:JC2116 G.GPAGRPAQRPLLGTNGATDDSK.T 2 2.942 0.146 O - human (91%) IPI:IPI00022579.1 PIR2:JC5832 neurotransmitter receptor - human K.SLAGAAKHERKAAK.T 1 2.154 0.149 G (94%) hepatocyte nuclear factor 4 gamma IPI:IPI00031455.1 PIR2:JC6095 K.RLAQPGMNFGSRVK.R 2 2.560 0.128 G chain - human (95%) 26S proteasome regulatory complex IPI:IPI00185374.1 PIR2:JC6523 L.SLEKQTRTASDMVSTSRILVA.V 2 2.404 0.134 O chain p55 - human (95%) N.KTTHLIAK.E 2 2.446 0.133 IPI:IPI00010086.1 PIR2:JC7312 frizzled-3 protein - human T.HASSTQLAMVDDQRSKAGSIHSKV.S 2 2.725 0.130 O (98%) Ig kappa chain NIG2 precursor - PIR2:JE0244 -.EVVLTQSPATLSVSPGER.A 2 4.580 0.424 G, O human E.VVLTQSPATLSVSPGER.A 2 3.238 0.449 V.HSNLAWYQQKPGQAPR.L 2 3.058 0.279 Ig lambda chain NIG76 precursor - P.VKAGVETTTPSKQSNNKTAASSYLSLT PIR2:JE0245 3 3.926 0.225 O, P human PEQWK.S nuclear matrix protein NMP 238 - PIR2:JE0334 I.NKVVNKYIDQGIAELV.P 2 2.465 0.124 O human Q.DVTLHDLDVAN.A 2 3.065 0.214 Ig heavy chain precursor V-D-J region PIR2:PH0115 C.DLQLVESGGGL.V 1 2.432 0.201 G (JP-FL-1) - human C.DLQLVESGGGLVQ.P 2 3.947 0.114 Ig kappa chain V region (anti-DNA, PIR2:PH0866 -.DIQITHSPSSLSASVGDR.V 2 3.164 0.224 G 1X7RG1) - human (fragment) Ig heavy chain V region (anti-DNA, IPI:IPI00161117.1 PIR2:PH0876 Y.IYYTGSTNYNPSLK.S 2 3.630 0.300 G IC4) - human (fragment) (93%) Ig heavy chain V region (clone CLL2) - PIR2:PH1233 A.ELQLVQSGAEVK.R 1 3.209 0.237 G, O human (fragment) 2 3.874 0.243 Ig heavy chain V region (clone IPI:IPI00018563.3 PIR2:PH1243 A.EVQLVQCGAEVK.K 1 2.717 0.218 G CORD1) - human (fragment) (98%) Ig heavy chain V region (clone IPI:IPI00018563.3 PIR2:PH1248 A.EVQLAQSGAEVK.K 1 3.193 0.255 G, O CORD6) - human (fragment) (96%) 2 2.602 0.161 Ig heavy chain V region (clone IPI:IPI00018563.3 PIR2:PH1249 A.XVQLVQSGAEVK.K 1 2.688 0.123 G, P CORD7) - human (fragment) (97%) 2 2.768 0.294 Ig heavy chain V region (clone P2-55) IPI:IPI00018563.3 PIR2:PH1420 R.GTLVTVPSASTQ.- 1 2.132 0.223 G - human (fragment) (94%) 2 2.616 0.281 Ig heavy chain V region (clone P3-60) IPI:IPI00018563.3 PIR2:PH1424 -.EEQLVQSGAEVK.K 1 2.788 0.218 G, O, P - human (fragment) (91%) 2 4.105 0.267 Ig kappa chain V region (clone PIR2:PN0537 -.EIVLTQSPGTVSLSPGER.A 1 1.864 0.172 G, O, P LUNm03) - human (fragment) 2 4.058 0.364 Ig kappa chain precursor V region IPI:IPI00177872.1 PIR2:S00996 G.EIVLTQSPDFQSVTPK.E 1 2.774 0.310 G, O, P (A10) - human (fragment) (97%) 2 4.188 0.459 K.YASQSFSGVPSR.F 1 2.208 0.175 2 3.596 0.451 R.ASQSIGSSLHWYQQKPDQSPK.L 2 4.733 0.286 3 3.547 0.212 S.LHWYQQKPDQSPK.L 2 2.728 0.181 Supplementary Table 1 155 S.SLHWYQQK.P 2 2.424 0.182 Ig kappa chain precursor V region PIR2:S10146 K.YASQSISGVPSR.F 2 2.685 0.327 G, P (A14) - human (fragment) Y.LYWYQQK.P 1 2.148 0.141 IPI:IPI00182650.1 PIR2:S12557 Ig heavy chain - human (fragment) C.EVQLVQSGGGLVHPGGSLR.L 2 3.286 0.281 G (92%) Q.LVQSGGGLVHPGGSLR.L 2 2.542 0.084 sphingomyelin phosphodiesterase (EC PIR2:S14747 Y.LSAPTKQPQIAKDFAAPQ.V 1 2.070 0.099 G 3.1.4.12) - human (fragments) T-cell receptor beta chain V region PIR2:S17385 R.GQQVTLRCSPISEHKSVS.W 1 2.750 0.098 A (clone IGRb08) - human (fragment) Ig heavy chain V region (VH5DJ) - PIR2:S19669 K.GLEWMGIIYPDDSDTR.Y 2 2.669 0.150 G human R.YSPSFEGQVTISVDK.S 2 2.620 0.290 IPI:IPI00003486.1 PIR2:S20637 Ig kappa chain V region - human R.ASQSLTSNYLAWYQQK.P 2 3.674 0.339 G (91%) PIR2:S20764 Ig heavy chain V region - human K.NTVYLQMNSLK.T 1 2.549 0.087 G, O K.SDGGTTDYAAPVK.G 1 2.245 0.296 2 3.617 0.451 PIR2:S20772 Ig heavy chain V region - human -.QVQLVESGGGFVKPGGSLR.L 2 3.287 0.176 O IPI:IPI00220120.1 PIR2:S20781 Ig heavy chain V region - human S.VSGGSTHYADSVK.G 2 2.823 0.142 P (97%) Ig lambda chain V region - human PIR2:S23626 N.IGGNTVNWYQQLPGTAPK.L 2 3.974 0.097 G (fragment) PIR2:S24319 Ig lambda chain precursor - human S.YVVTQPPSVSVAPGQTAR.I 2 4.533 0.473 G, O, P PIR2:S24320 Ig kappa chain precursor - human C.DIQMTQSPSSLSASVGDGV.T 1 3.094 0.342 G, O, P 2 5.951 1.000 myosin-binding protein C, skeletal E.GATKADAADYSVMTTGGQSSAKLSVD PIR2:S24614 3 3.541 0.178 G muscle - human LKPLK.I IPI:IPI00007892.1 PIR2:S25573 Ig heavy chain V region - human C.EVQQVESGGGLVKPGGSLR.L 1 2.748 1.000 G, O, P (92%) 2 4.504 0.242 Q.QVESGGGLVKPGGSLR.L 2 3.754 0.360 PIR2:S25574 Ig heavy chain V region - human C.EVHLVESGGGLVEPGR.S 2 2.744 0.283 G H.LVESGGGLVEPGR.S 2 4.194 0.193 PIR2:S25740 Ig lambda chain - human (fragment) K.PGQAPILVIYGQ.N 2 3.740 0.173 G IPI:IPI00154742.1 PIR2:S25743 Ig lambda chain - human (fragment) R.VTISCTGSSSNIGAGF.D 1 2.129 0.172 G (91%) IPI:IPI00154742.1 PIR2:S25746 Ig lambda chain - human K.ADSSPVTAGVETTTPSK.Q 2 2.838 0.428 G, P (92%) P.VTAGVETTTPSKQSNNKYAASSYLSLT 3 4.131 0.273 PEQWK.S V.TAGVETTTPSKQSNNK.Y 2 2.794 0.170 IPI:IPI00166489.1 PIR2:S25747 Ig lambda chain - human R.FSGSNSGNTATLNISR.V 2 2.350 0.222 O, P (95%) S.YVLTQPPSVSVAPGKAAR.I 2 3.382 0.212 PIR2:S25758 Ig lambda chain - human K.VSVLGQPK.A 1 1.811 0.178 G PIR2:S25759 Ig lambda chain - human V.RAGVETTTPSK.Q 2 2.856 0.260 G, O V.RAGVETTTPSKQSNNKYAASSYLSLTP 3 3.576 0.277 EQWK.S Y.FVSWYQQYPGK.A 2 2.471 0.268 A.SVGDRVTITCRASQGISSYLAWYQQKP PIR2:S30521 Ig kappa chain V region - human 3 3.544 0.081 G GKAPR.L S.YLAWYQQKPGKAPR.L 1 2.414 1.000 IPI:IPI00180166.1 PIR2:S30533 Ig heavy chain V region - human -.EVQVVESGGGLVKPGGSLR.L 2 4.921 1.000 G, O, P (91%) 3 4.117 0.204 Q.VVESGGGLVKPGGSLR.L 2 4.149 0.317 PIR2:S31120 Ig heavy chain - human R.AEDTAVYYCASGNF.D 2 2.784 0.156 G Ig heavy chain V region - human PIR2:S31592 R.AEDTAVYYCAKDHIVGATYFDYWGQ.G 3 3.518 0.085 G (fragment) Ig heavy chain V region - human PIR2:S31689 P.SQTLSLTWAISGDSVSSNSAAWNWI.R 2 3.006 0.088 G (fragment) Ig heavy chain V region - human IPI:IPI00220120.1 PIR2:S31699 C.EVQLLESGGGLVHPGGSLR.L 2 2.860 0.357 G (fragment) (91%) PIR2:S31977 Ig kappa chain - human A.YLNWYQKK.P 1 2.182 0.147 G, P A.YLNWYQKKPGK.A 2 3.652 0.125 Y.LNWYQKKPGK.A 2 2.924 1.000 PIR2:S31978 Ig kappa chain - human (fragment) G.TDFTLTISTLQPDDFATYY.C 2 3.021 0.109 A, O PIR2:S34012 Ig heavy chain V region - human R.QAPGKGLEWVSSS.S 2 2.896 0.101 O Supplementary Table 1 156 PIR2:S34014 Ig heavy chain V region - human -.QVQMVQSGAEVK.K 2 3.537 0.156 P Ig heavy chain V region (clone alpha- IPI:IPI00007898.2 PIR2:S36270 K.NTLYLQMDNLR.A 2 3.681 0.128 G TNF-E1) - human (fragment) (92%) Ig kappa chain V region (V-kappa 3) - PIR2:S37501 A.SQRIGSSYLAWYQQKPGQAPR.L 2 2.755 0.179 G human (fragment) Ig kappa chain V region (V-kappa 3) - PIR2:S37507 R.LLIHGASNR.A 1 2.418 0.184 G human (fragment) Ig kappa chain V region (V-kappa 3) - IPI:IPI00030206.1 PIR2:S37510 R.ASQSVSSTYLAWYQQQ.P 2 3.028 0.310 G human (fragment) (91%) R.ASQSVSSTYLAWYQQQPGQAPR.L 2 4.037 0.290 T.YLAWYQQQPGQAPR.L 2 2.930 1.000 Ig kappa chain V region (V-kappa 3) - IPI:IPI00024136.1 PIR2:S37521 R.ARQSVSSYLAWYQQKPGQAPR.L 2 2.574 0.131 G human (fragment) (97%) PIR2:S40315 Ig kappa chain - human R.SSQTIGTYLNWYQQK.P 2 2.616 0.192 G, O S.APPYTFGQGTR.L 2 2.928 0.167 IPI:IPI00160257.2 PIR2:S40316 Ig kappa chain - human C.DIQLTQSPSSVSA.S 2 3.258 0.172 G (91%) C.DIQLTQSPSSVSASVGDR.V 2 2.973 0.352 PIR2:S40317 Ig kappa chain - human C.DIQMTQSPSSLSTSL.G 2 3.782 0.298 G C.DIQMTQSPSSLSTSLGDR.V 2 2.744 0.201 R.SSQSLLHSNGYDYLDWYLQKPGQSPQ IPI:IPI00178045.1 PIR2:S40319 Ig kappa chain V region - human 3 4.221 0.366 G LLIY.L (97%) R.SSQSLLHSNGYDYLDWYLQKPGQSPQ 3 4.101 0.346 LLIYLGSNR.A PIR2:S40320 Ig kappa chain - human R.FSGSGSGTEFTLK.I 1 2.411 0.276 G, O, P 2 3.657 0.340 PIR2:S40323 Ig kappa chain - human R.FSGSGSGTDFTLE.I 1 2.346 0.094 G, P 2 3.159 0.119 R.FSGSGSGTDFTLEISR.V 2 3.307 0.281 IPI:IPI00026195.1 PIR2:S40324 Ig kappa chain V region - human G.DVVLTQSPL.S 1 2.222 0.189 G (93%) PIR2:S40334 Ig kappa chain - human C.DIQLTQSPSFLSASIGDR.V 2 4.511 0.481 O, P IPI:IPI00178045.1 PIR2:S40339 Ig kappa chain - human R.FTGSGSGTDFTLK.I 1 2.544 0.182 G, P (96%) 2 3.749 0.378 PIR2:S40341 Ig kappa chain - human R.IEFPWTFGQGTK.V 2 2.607 0.151 G IPI:IPI00178198.1 PIR2:S40344 Ig kappa chain V-J region - human G.EVVLTQSPATLSLSPGER.A 1 2.263 0.143 G, O, P (93%) 2 4.945 0.420 IPI:IPI00026197.1 PIR2:S40347 Ig kappa chain - human K.NYLAWYQQKPGQPPQ.L 2 4.342 0.383 G, O, P (95%) K.TPLTFGQGTE.V 1 2.133 0.186 PIR2:S40349 Ig kappa chain V-J region - human N.TYPLTFGGGTK.V 1 1.846 0.353 G PIR2:S40351 Ig kappa chain V-J-C region - human W.LAWYKQK.P 1 2.034 0.086 G IPI:IPI00026197.1 PIR2:S40364 Ig kappa chain - human K.NYLAWYQHKPGQPPR.L 2 2.509 0.266 G (91%) PIR2:S40373 Ig kappa chain - human R.SSQSLVHSNGDTYLSWLQQR.P 3 4.020 0.237 G, O IPI:IPI00178229.1 PIR2:S40379 Ig kappa chain V-J region - human E.FVLTQSPATLSLSPGER.A 2 4.392 0.328 A, G, O (95%) G.EFVLTQSPATLSLSPGER.A 2 3.844 0.423 L.LLWLPDTTGEFVLTQSPATLSL.S 2 2.447 0.148 PIR2:S41810 Ig kappa chain V region L14 - human C.NIQMTQSPSAMSASVGDR.V 2 4.342 0.290 G, P FLT3/FLK2 ligand (clone S109) - IPI:IPI00216372.1 PIR2:S43293 R.QRQNPAPAPFTQ.L 1 2.392 0.113 G human (94%) IPI:IPI00026197.1 PIR2:S44116 Ig kappa chain V-J region - human N.KTYLAWYQQKPGQPPK.L 2 3.230 0.374 G (93%) PIR2:S44118 Ig kappa chain V-J region - human P.PGVTFGPGTK.V 1 1.884 0.082 G Ig kappa chain V-J region (T24-9) - PIR2:S46373 K.SSQSVLSSSNNK.N 1 2.923 0.206 G, O human (fragment) 2 2.998 0.305 Ig kappa chain V-J region (T33-4) - PIR2:S46374 C.DVQMTQSPSTLSASVGDR.V 2 5.649 0.510 G, O human (fragment) Ig kappa chain V-J region (T33-14) - IPI:IPI00160257.2 PIR2:S46376 C.DIQMTQSPSSVSASIGDR.V 1 2.411 0.208 G, O human (fragment) (96%) 2 4.029 0.427 R.ASQDISSWLAWYQQKPGK.A 2 3.209 0.093 IPI:IPI00009792.1 PIR2:S46393 Ig heavy chain V region - human S.AYYYDSSGYYSANYYMDV.W 2 2.720 0.106 P (95%) Ig lambda chain V region (VL-16) - PIR2:S46397 K.YVSWYQQQ.P 1 2.499 0.257 G human
Supplementary Table 1 157 Y.KYVSWYQQQ.P 1 2.956 0.277 granulocyte-macrophage colony- IPI:IPI00219208.1 PIR2:S50039 stimulating factor receptor alpha-S2 L.DVHRKNTQPGTENLLVVL.T 2 2.469 0.153 O (99%) chain, soluble isoform - human Q.LDVHRKNTQPGTENLLVVLTTGTSAL.C 2 2.813 0.210 sodium channel alpha subunit - PIR2:S54771 L.VDGRSALMLPNGQLLPE.G 2 2.922 0.161 A, G, P human S.QASRSPPMLPVNGKMHSAVDCNGVVS 2 2.421 0.175 LVDGRSA.L Ig lambda chain V-J region - human PIR2:S57412 K.LMIYAVNKRPSGVPDR.F 2 2.800 0.222 G, P (fragment) familial Alzheimer's disease protein 1 - PIR2:S65358 L.FPPSPSSARPF.L 1 2.165 0.114 G human Ig heavy chain V region precursor - Q.GTLVTVSSEPKSCDKTHTCPPCPAPEL IPI:IPI00152302.1 PIR2:S69339 3 3.954 0.358 G human LGGPSVFLFPPKPK.D (97%) IPI:IPI00184891.1 PIR2:S69890 mitogen inducible gene mig-2 - human T.DLNRDITLRVTGEVHIGGVML.K 2 2.658 0.178 A (93%) Ig heavy chain V region (clone IPI:IPI00007891.1 PIR2:S69896 G.RIGYADSVK.G 1 2.205 0.231 G RFKL5H), rheumatoid factor - human (93%) PIR2:S69910 Ig V-D-J region (KR) - human K.NTLYLEMDSLR.A 2 3.912 0.178 G IPI:IPI00022479.1 PIR2:S71752 giant protein p619 - human D.ENLPIQEVSFDPEK.A 1 2.745 0.135 O, P (91%) BH-protocadherin PCDH7 (clone BH- PIR2:T00042 K.LSTFMPVDER.G 1 1.964 0.147 P Pcdh-c) - human hypothetical protein KIAA0462 - IPI:IPI00180305.1 PIR2:T00076 G.CGHTSSTKCYGCASAVTEHCITLLR.A 2 2.216 0.155 A, O human (fragment) (92%) K.KNKDVPVEALTTVKPYCNEI.H 2 2.493 0.171 hypothetical protein KIAA0522 - PIR2:T00080 P.QLLLPVPPAPALSPGPPR.A 1 2.129 0.151 P human (fragment) hypothetical protein KIAA0518 - IPI:IPI00163866.1 PIR2:T00081 L.KDSSIEMELRKVTSAIE.E 2 2.989 0.148 A human (fragment) (94%) LDL receptor related protein 105 - PIR2:T00204 L.GYDDYVQVYEG.L 2 2.762 0.207 G, O human L.PSGLRDP.E 1 2.025 0.130 L.LLLGVGDPSGPGANGSADSQGLLFFR. PIR2:T00209 MEGF8 protein - human (fragment) 2 2.538 0.100 G, P Q Q.EKAPQTVELPAVAGHTLTAR.R 2 2.248 0.104 hypothetical protein KIAA0477 - IPI:IPI00186359.1 PIR2:T00259 R.QKERQLADAKQCVQFVEAAAHE.S 2 2.844 0.126 A human (91%) hypothetical protein KIAA0603 - IPI:IPI00177464.1 PIR2:T00261 K.NKAKRSLTSSLENIFS.R 1 1.820 0.108 P human (92%) V.MLTLKQAFSTAAALQSAKTQI.K 2 2.528 0.118 hypothetical protein KIAA0564 - IPI:IPI00181685.1 PIR2:T00335 T.EGLSSVVR.N 1 1.823 0.152 A, G human (fragment) (97%) W.AGGTGGRDTAGLGGKGGPYRLDAGH 2 2.478 0.124 T.V hypothetical protein KIAA0583 - IPI:IPI00152562.2 PIR2:T00346 P.EKLSVYK.K 1 1.934 0.105 A human (fragment) (91%) hypothetical protein KIAA0675 - IPI:IPI00005647.1 PIR2:T00362 I.NTLPKGVVPHIKKFLQ.E 1 2.117 0.104 A, G, O, P human (94%) L.GMMQEDIDK.V 2 2.631 0.143 hypothetical protein KIAA0649 - PIR2:T00373 A.PKLLKETKAP.P 1 2.082 0.082 G human IPI:IPI00168769.1 PIR2:T00385 KIAA0624 protein - human (fragment) F.LIHGRQSGSKIMAASLRNG.P 2 2.698 0.090 A, P (93%) L.QGVTGEWFEEIQRKK.F 1 1.816 0.085 hypothetical protein KIAA0615 - IPI:IPI00005667.1 PIR2:T00389 I.ADLSDSSADSENLSP.D 2 2.917 0.102 O, P human (95%) V.EKFSQLPFKVEAK.P 2 2.334 0.115 hypothetical protein H_248O15.1 - PIR2:T00415 Y.VQHSDLSKIEI.H 1 2.219 0.110 G, O human (fragment) N-chimerin homolog F25965_3 - PIR2:T00705 Y.RLSGVSSNIQRLR.H 2 2.730 0.106 P human IPI:IPI00027220.1 PIR2:T03097 CDO protein - human R.TCCQDIVNDVSSDGSEDPAEF.S 2 2.988 0.150 G, P (96%) S.SDDVHILHPTHSQAL.A 1 2.055 0.124 IPI:IPI00020193.1 PIR2:T03454 ALR protein - human K.QLDQVRKQQK.E 2 2.350 0.132 O, P (97%) S.LPETDDSLLCDAGTAISGGKAEGEK.G 2 2.256 0.156 probable transcription factor CA150 - PIR2:T08599 K.KKREHFRQLLDETSAI.T 1 2.274 0.088 G, O, P human K.MMEEAKFN.P 1 2.606 0.098 TGF beta receptor associated protein S.EERPPIVKRIGRQEFLLAGPGGLGMFA IPI:IPI00221152.1 PIR2:T08622 3 4.025 0.092 A 1 - human TVAGI.S (99%) Supplementary Table 1 158 hypothetical protein PIR2:T08762 DKFZp586P2219.1 - human S.SFSISASLHKPEMETELK.G 2 2.865 0.098 A (fragment) immunoglobulin-like protein IGSF1 - IPI:IPI00043215.1 PIR2:T09402 L.VFMLFKEGYAE.P 1 2.321 0.218 A, G human (98%) N.PLKLVVAGLYPK.P 1 1.903 0.164 hypothetical protein DKFZp570I0164.1 PIR2:T12490 Y.ECNKCGKTFKKKK.K 2 2.684 0.094 P - human hypothetical protein DKFZp434B094.1 IPI:IPI00032214.1 PIR2:T12534 A.SAVAEPASDVNR.R 2 2.348 0.123 A - human (fragment) (94%) L.FCKSKSVSPPKSAKNTETQPT.S 2 2.737 0.206 PIR2:T13151 adapter protein CMS - human L.KPSELKK.D 1 1.808 0.108 P hypothetical protein DKFZp434L108.1 IPI:IPI00171498.1 PIR2:T17316 K.QFLEKCLQHKDIPVPKGFLT.S 2 2.715 0.113 G - human (fragment) (97%) hypothetical protein IPI:IPI00168698.1 PIR2:T34546 DKFZp434B0328.1 - human A.KDVTSETFCPTK.D 2 2.304 0.131 G (97%) (fragment) L.AKSGERLQALTLLMIHYRAG.I 2 2.491 0.150 hypothetical protein DKFZp434A128.1 IPI:IPI00181087.1 PIR2:T34567 G.GASCCSSLSAQV.M 1 2.309 0.106 A, O - human (95%) L.LEDQLSKLKDERASLQDELR.E 2 2.205 0.185 hypothetical protein DKFZp566O224.1 PIR2:T42645 K.EPGAPVALYSSPL.L 1 2.189 0.097 G - human hypothetical protein PIR2:T42657 DKFZp434J1015.1 - human V.QPELQLELVPAAGGGGAAV.P 1 2.026 0.177 A (fragment) hypothetical protein IPI:IPI00185059.1 PIR2:T42691 DKFZp434D2328.1 - human A.LMMAAENGQAGAVDILVNSAQADL.T 2 2.900 0.110 G, P (98%) (fragment) hypothetical protein PIR2:T46277 DKFZp564M2178.1 - human Q.ELFCSACDQLF.L 1 2.036 0.086 P (fragment) T.EALLLAHRR.A 1 1.932 0.146 hypothetical protein PIR2:T46319 DKFZp434G0812.1 - human L.PDLRQVAELTLLGAGMRDAFQM.A 2 2.797 0.184 O (fragment) hypothetical protein IPI:IPI00017244.1 PIR2:T46335 DKFZp434L1713.1 - human K.ALPDVELVQ.H 1 2.454 0.228 A, G, O, P (94%) (fragment) hypothetical protein IPI:IPI00018061.1 PIR2:T46347 DKFZp434K0614.1 - human P.QHRFPAAGLEQEEFDVFTK.A 2 2.883 0.123 A (92%) (fragment) hypothetical protein DKFZp434C198.1 IPI:IPI00022271.1 PIR2:T46499 E.IPQIVEISIEK.D 2 2.584 0.117 G - human (95%) Q04917 homo sapiens (human). 14-3- SW:143F_HUMAN A.FEISKEQMQPTHPIRLGLA.L 2 2.995 0.104 G 3 protein eta (protein as1). 10/2001 Q29631 homo sapiens (human). hla class i histocompatibility antigen, cw-7 SW:1C11_HUMAN I.MGIVAGLAVLVV.L 1 2.332 0.126 A cw*0704 alpha chain precursor. 10/2001 P30509 homo sapiens (human). hla class i histocompatibility antigen, SW:1C16_HUMAN A.VLAVLAVLGAVMAVVMCRRK.S 2 2.519 0.089 P cw*1202 alpha chain precursor (hla- cb-2) (cw*0602) (cw6). 10/2001 Q06190 homo sapiens (human). serine/threonine protein phosphatase 2a, 72/130 kda regulatory subunit b IPI:IPI00218930.1 SW:2ACA_HUMAN K.ALDKGQKTENGPSHELLK.V 1 2.128 0.145 A (pp2a, subunit b, b''-pr72/pr130) (98%) (pp2a, subunit b, b72/b130 isoforms) (pp2a, subunit P78314 homo sapiens (human). sh3 IPI:IPI00218997.1 SW:3BP2_HUMAN domain-binding protein 3bp-2. F.KSSTSASPQGAFSLSG.Y 1 2.257 0.093 G (97%) 12/1998 P51857 homo sapiens (human). 3- oxo-5-beta-steroid 4-dehydrogenase K.DALLNSLGKRYNKTAAQIVLRFNIQRGV IPI:IPI00065073.1 SW:3O5B_HUMAN 3 4.141 0.223 G (ec 1.3.99.6) (delta(4)-3- ketosteroid VVIPKS.F (94%) 5-beta-reductase). 10/2001 P28222 homo sapiens (human). 5- hydroxytryptamine 1b receptor (5-ht- IPI:IPI00002184.1 SW:5H1B_HUMAN 1b) (serotonin receptor) (5-ht-1d-beta) S.ESGSPVYVNQV.K 1 2.018 0.138 A (95%) (serotonin 1d beta receptor) (s12). 10/2001 P28221 homo sapiens (human). 5- hydroxytryptamine 1d receptor (5-ht- M.SPLNQSAEGLPQEASNRSLNATETSE IPI:IPI00002183.1 SW:5H1D_HUMAN 3 3.542 0.117 P 1d) (serotonin receptor) (5-ht-1d- AWDPR.T (96%) alpha). 10/2001 Supplementary Table 1 159 Q13639 homo sapiens (human). 5- IPI:IPI00064638.1 SW:5H4_HUMAN hydroxytryptamine 4 receptor (5-ht-4) A.DLLVSVLVMPF.G 1 2.639 0.121 P (99%) (serotonin receptor) (5-ht4). 10/2001 P21589 homo sapiens (human). 5'- nucleotidase precursor (ec 3.1.3.5) IPI:IPI00009456.1 SW:5NTD_HUMAN T.YISKMK.V 1 1.975 0.139 O (ecto-5'-nucleotidase) (5'-nt) (cd73 (95%) antigen). 10/2001 Q9y2g3 homo sapiens (human). potential phospholipid-transporting SW:A11B_HUMAN A.VFQFIEK.D 1 2.324 0.130 P atpase ir (ec 3.6.3.13) (fragment). 10/2001 P50993 homo sapiens (human). sodium/potassium-transporting atpase IPI:IPI00003021.1 SW:A1A2_HUMAN alpha-2 chain precursor (ec 3.6.3.9) I.EHFIQLITGVAVFLGVSFF.I 2 2.840 0.087 G (97%) (sodium pump 2) (na+/k+ atpase 2). 10/2001 V.EVKGGDRVPADLRII.S 2 2.977 0.137 Q13733 homo sapiens (human). sodium/potassium-transporting atpase IPI:IPI00182308.1 SW:A1A4_HUMAN alpha-4 chain (ec 3.6.3.9) (sodium N.QEILPIAK.R 1 1.819 0.083 O (95%) pump 4) (na+/k+ atpase 4) (fragment). 10/2001 P19652 homo sapiens (human). alpha-1-acid glycoprotein 2 precursor SW:A1AH_HUMAN F.YIASAFR.N 1 2.085 0.119 G, O, P (agp 2) (orosomucoid 2) (omd 2). 10/2001 K.NWGLSFYADKPETTK.E 2 5.016 0.440 K.TEDTIFLR.E 1 1.966 0.082 K.TLMFGSYLDDEK.N 2 3.559 0.449 K.TLMFGSYLDDEKNWGLSFYADKPETT 2 2.835 0.364 K.E 3 5.019 0.406 K.WFYIASAFR.N 1 2.045 0.145 2 3.624 0.292 R.EHVAHLLFL.R 2 2.466 0.240 R.EHVAHLLFLR.D 1 1.990 0.255 2 3.566 0.389 R.SDVMYTDWK.K 1 2.780 0.227 2 3.657 0.370 R.YEGGREHVAHLLFLR.D 2 3.510 0.346 3 4.540 0.362 R.YEGGREHVAHLLFLRDTK.T 2 2.410 0.224 3 4.451 0.398 S.FYADKPETTK.E 2 2.424 0.280 P01009 homo sapiens (human). alpha-1-antitrypsin precursor (alpha-1 SW:A1AT_HUMAN -.EDPQGDAAQK.T 1 1.992 0.213 A, G, O, P protease inhibitor) (alpha-1- antiproteinase). 10/2001 2 2.519 0.170 -.EDPQGDAAQKTDTSHHDQDHPTFNK.I 2 2.684 0.253 3 4.250 0.418 A.QIHEGFQELLPTLNQPDSQLQLTTGNG 3 3.916 0.227 LFLSEGLK.L A.VLTIDEK.G 1 2.191 0.199 D.AAQKTDTSHHDQDHPTFNK.I 3 3.941 0.328 D.EGKLQHLENELTHDIITK.F 3 4.572 0.240 D.FHVDQVTTVK.V 2 2.675 0.265 D.LSGVTEEAPLKLSK.A 2 4.082 0.298 D.PQGDAAQKTDTSHHDQDHPTFNK.I 3 5.027 0.320 D.TSHHDQDHPTFNK.I 2 3.473 0.365 F.ALVNYIFFK.G 2 3.082 0.258 F.LMIEQNTK.S 1 1.858 0.083 F.NKPFVFLMIEQNTK.S 2 4.465 0.257 3 4.578 0.097 F.SNGADLSGVTEEAPLK.L 2 5.064 0.468 F.SNGADLSGVTEEAPLKLSK.A 2 4.371 0.414 F.TVNFGDTEEAK.K 1 2.380 0.315 2 2.416 0.227 F.TVNFGDTEEAKK.Q 2 2.957 0.272
Supplementary Table 1 160 F.VFLMIEQNTK.S 2 3.444 0.161 G.DAAQKTDTSHHDQDHPTFNK.I 3 4.794 0.372 H.HDQDHPTFNK.I 2 2.741 0.300 I.PEAQIHEGFQELLR.T 1 2.820 0.164 I.PMSIPPEVK.F 1 1.987 0.227 I.TPNLAEFAFSLYR.Q 2 4.305 0.380 K.AVHKAVLTIDEK.G 2 3.764 0.450 K.AVLTIDEK.G 1 2.611 0.110 2 2.793 0.125 K.DTEEEDFHVDQVTTVK.V 1 3.187 0.328 2 5.582 0.390 K.DTEEEDFHVDQVTTVKVPMMK.R 3 5.246 0.503 K.ELDRDTVFALVN.Y 2 2.764 0.146 K.ELDRDTVFALVNYIFFK.G 2 5.334 0.434 3 4.961 0.210 K.FLEDVKK.L 2 2.686 0.083 K.FLENEDR.R 1 2.351 0.108 2 2.788 0.174 K.FLENEDRR.S 2 2.556 0.095 K.FNKPFVFLMIEQN.T 2 3.752 0.085 K.FNKPFVFLMIEQNTK.S 1 4.443 0.182 2 5.472 0.301 3 4.924 0.207 K.FNKPFVFLMIEQNTKSPLFMGK.V 3 3.880 0.301 K.GKWERPFEVK.D 2 3.569 0.236 K.GKWERPFEVKD.T 2 3.146 0.277 K.GKWERPFEVKDTEEEDFHVDQVTTVK. 2 3.281 0.239 V 3 6.735 0.413 K.GKWERPFEVKDTEEEDFHVDQVTTVK 3 3.605 0.192 VPM.M K.GKWERPFEVKDTEEEDFHVDQVTTVK 3 6.240 0.406 VPMMK.R K.GTEAAGAMFLEAIPM.S 2 4.851 0.237 K.GTEAAGAMFLEAIPMSIPPEVK.F 2 4.905 0.463 3 4.305 0.294 K.ITPNLAEFAF.S 1 2.136 0.174 2 3.091 0.197 K.ITPNLAEFAFSL.Y 2 3.149 0.264 K.ITPNLAEFAFSLY.R 2 3.814 0.352 K.ITPNLAEFAFSLYR.Q 1 2.836 0.085 2 4.239 0.398 3 4.093 0.360 K.IVDLVK.E 1 1.966 0.081 K.IVDLVKELDRDTVFALVNYIFFK.G 2 4.116 0.418 3 6.760 0.512 K.KLSSWVLLMK.Y 2 3.611 0.206 K.KLYHSEAFTVNFGDTEEAK.K 2 4.149 0.422 3 4.196 0.273 K.KLYHSEAFTVNFGDTEEAKK.Q 2 5.585 0.476 3 5.582 0.317 K.KLYHSEAFTVNFGDTEEAKKQINDYVE 3 6.005 0.507 K.G K.KQINDYVEK.G 1 2.890 0.283 2 3.691 0.184 K.KQINDYVEKGTQGK.I 1 3.742 0.299 2 4.646 0.340 3 4.202 0.328 K.LQHLENELTHD.I 2 2.919 0.210 K.LQHLENELTHDIITK.F 1 4.407 0.348 2 5.459 0.386 3 4.863 0.375 K.LSITGTYDLK.S 1 2.203 0.147 2 3.252 0.333 K.LSSWVLLMK.Y 2 2.778 0.240 Supplementary Table 1 161 K.LVDKFLEDVK.K 1 2.816 0.134 2 3.206 0.231 K.LVDKFLEDVKK.L 1 3.292 0.191 2 4.468 0.307 K.LVDKFLEDVKKLYHSEAFTVNFGDTEE 3 4.824 0.452 AK.K K.LVDKFLEDVKKLYHSEAFTVNFGDTEE 3 6.106 0.530 AKK.Q K.LYHSEAFTVNFGDTEEAK.K 2 5.895 0.525 3 3.597 0.195 K.LYHSEAFTVNFGDTEEAKK.Q 2 6.054 0.495 3 5.088 0.360 K.LYHSEAFTVNFGDTEEAKKQINDYVEK. 3 5.269 0.461 G K.LYHSEAFTVNFGDTEEAKKQINDYVEK 3 5.292 0.409 GTQGK.I K.QINDYVEK.G 2 2.585 0.216 K.QINDYVEKGTQGK.I 2 3.691 0.202 K.SPLFMGK.V 1 2.313 0.223 K.SVLGQLGITK.V 1 2.220 0.293 2 3.302 0.298 K.SVLGQLGITKVFSNGADLSGVTEEAPL 3 6.262 0.489 KLSK.A K.TDTSHHDQDHPTFNK.I 1 2.904 0.263 2 4.283 0.364 3 4.426 0.301 K.TDTSHHDQDHPTFNKITPNLAEFAFSLY 3 5.015 0.373 R.Q K.VFSNGADLSGVTEEAPLK.L 1 3.188 0.273 2 5.599 0.326 3 4.757 0.383 K.VFSNGADLSGVTEEAPLKL.S 2 3.854 0.323 K.VFSNGADLSGVTEEAPLKLS.K 2 5.301 0.473 K.VFSNGADLSGVTEEAPLKLSK.A 2 5.191 0.412 3 4.598 0.381 K.VVNPTQK.- 1 1.941 0.131 K.WERPFEVK.D 2 2.575 0.093 K.WERPFEVKDTEEEDFHVDQVTTVK.V 3 5.194 0.337 L.ENELTHDIITK.F 2 2.349 0.169 L.LGQLGITK.V 1 2.085 0.090 L.SITGTYDLK.S 1 1.952 0.100 2 2.400 0.213 L.VDKFLEDVKK.L 2 3.492 0.148 M.SIPPEVKFNKPFVFLMIEQNTKSPLFMG 3 5.978 0.414 KVVNPTQK.- N.GADLSGVTEEAPLK.L 2 4.325 0.254 N.GADLSGVTEEAPLKLSK.A 2 4.633 0.476 N.LAEFAFSLYR.Q 2 3.306 0.195 N.STNIFFSPVSIATAF.A 2 3.492 0.317 P.NLAEFAFSLYR.Q 2 4.133 0.382 P.TLNQPDSQLQL.T 2 2.651 0.208 P.TLNQPDSQLQLTTGNGLFLSEGLK.L 2 6.037 0.468 3 4.906 0.363 Q.GDAAQKTDTSHHDQDHPTFNK.I 2 2.275 0.119 Q.IHEGFQELLR.T 2 2.864 0.310 R.SASLHLPK.L 2 2.990 0.161 R.SASLHLPKLSITGTYDLKSVLGQLGITK. 3 5.292 0.452 V S.VLGQLGITK.V 1 1.874 0.180 2 2.794 0.304 T.PNLAEFAFSLYR.Q 2 4.186 0.363 T.SHHDQDHPTFNK.I 2 3.435 0.246 V.FSNGADLSGVTEEAPLK.L 2 2.808 0.246 P04217 homo sapiens (human). IPI:IPI00216722.1 SW:A1BG_HUMAN A.PLSGVDFQ.L 1 2.020 0.153 A, G, O, P alpha-1b-glycoprotein. 10/2001 (99%) A.PPPPVLMHHGESSQVLHPGNK.V 2 3.644 0.418
Supplementary Table 1 162 A.TWSGAVLAGR.D 2 2.337 0.108 H.HGESSQVLHPGNK.V 2 3.586 0.292 K.ELLVPR.S 1 1.881 0.186 K.HQFLLTGDTQGR.Y 1 3.009 0.380 2 4.073 0.378 K.LLELTGPK.S 1 2.373 0.206 2 2.545 0.219 K.NGVAQEPVHLDSPAIK.H 1 2.382 0.100 2 4.967 0.483 K.NGVAQEPVHLDSPAIKHQFLLTGDTQG 3 5.476 0.439 R.Y K.SLPAPWLSMAPVS.W 2 2.687 0.336 K.SLPAPWLSMAPVSWITPGLK.T 2 4.599 0.434 L.IFVGPQHAGNYR.C 2 2.894 0.254 L.ILSDETLPAPEFSPEPESGR.A 2 4.290 0.434 L.PAPEFSPEPESGR.A 1 2.256 0.357 M.HHGESSQVLHPGNK.V 2 2.613 0.186 N.GVAQEPVHLDSPAIK.H 2 3.743 0.297 P.GAAANLELIFVGPQHAGNYR.C 2 4.130 0.310 3 4.931 0.337 P.TPGAAANLELIFVGPQHAGNY.R 2 4.935 0.446 P.TPGAAANLELIFVGPQHAGNYR.C 2 5.432 0.453 3 6.737 0.485 Q.PSLWAESESLLKPLANVTLTCQARL.E 2 2.442 0.114 R.ATWSGAVLAGR.D 2 3.813 0.324 R.LELHVDGPPPR.P 2 3.114 0.239 R.LELHVDGPPPRPQL.R 2 2.878 0.135 R.LELHVDGPPPRPQLR.A 2 2.696 0.241 3 4.070 0.349 R.LETPDFQLFK.N 1 2.394 0.118 2 2.713 0.188 R.LETPDFQLFKNGVAQEPVHLDSPAIK.H 3 4.785 0.202 R.LHDNQNGWSGDSAPVELILSDETLPAP 3 4.917 0.363 EFSPEPESGR.A R.RGEKELLVPR.S 2 3.379 0.278 R.SGLSTGWTQLSK.L 1 2.898 0.393 2 3.972 0.376 R.SWVPHTFESELSDPVELLVAES.- 2 3.825 0.383 R.TDGEGALSEPSATVTIEELAAPPPPVL 3 4.237 0.400 MHHGESSQVLHPGNK.V R.YRLHDNQNGWSGDSAPVELILSDETLP 3 4.519 0.358 APEFSPEPESGR.A S.APVELILSDETLPAPEFSPEPESGR.A 2 2.829 0.272 V.AQEPVHLDSPAIK.H 2 2.216 0.180 P08697 homo sapiens (human). alpha-2-antiplasmin precursor (alpha- IPI:IPI00182466.1 SW:A2AP_HUMAN K.EQQDSPGNKDFLQSLK.G 2 3.095 0.285 O, P 2-plasmin inhibitor) (alpha-2-pi) (96%) (alpha-2-ap). 10/2001 K.GFPIKEDFLEQSEQLFG.A 2 3.207 0.216 K.GFPIKEDFLEQSEQLFGAK.P 2 4.573 0.445 3 3.696 0.324 K.GFPIKEDFLEQSEQLFGAKPVSLTGK.Q 3 5.154 0.411 K.LGNQEPGGQTALK.S 1 2.517 0.297 2 3.564 0.173 K.QEDDLANINQWVK.E 2 3.910 0.375 L.VPPMEEDYPQFGSPK.- 2 2.469 0.271 P.NQEQVSPLTLLK.L 2 3.651 0.113 R.DSFHLDEQFTVPVEMMQA.R 2 3.191 0.389 R.DSFHLDEQFTVPVEMMQAR.T 2 4.718 0.350 R.ELKEQQDSPGNK.D 2 3.912 0.226 R.ELKEQQDSPGNKDFLQSLK.G 2 5.002 0.448 3 4.166 0.338 R.GDKLFGPDLK.L 1 1.927 0.093 2 3.074 0.201 R.MSLSSFSVNRPFLFFIFEDTTGLPLFVG 3 3.843 0.359 SVR.N Supplementary Table 1 163 R.MSLSSFSVNRPFLFFIFEDTTGLPLFVG 3 4.147 0.191 SVRNPNPSAPR.E R.NKFDPSLTQR.D 2 2.309 0.116 R.WFLLEQPEIQVAHFPFK.N 2 5.758 0.326 3 3.668 0.262 V.PPMEEDYPQFGSPK.- 2 4.412 0.434 W.QLTSGPNQEQVSPLTLLK.L 2 4.413 0.443 P21851 homo sapiens (human), rattus norvegicus (rat) adapter-related protein complex 2 beta 1 subunit IPI:IPI00220991.1 SW:A2B1_HUMAN L.IVQKRPEILKQEIKVFFVKY.N 2 2.652 0.124 A, O (beta-adaptin) (plasma membrane (92%) adaptor ha2/ap2 adaptin beta subunit) (clathrin assemb N.IAQVLAELK.E 1 1.966 0.101 P02750 homo sapiens (human). SW:A2GL_HUMAN leucine-rich alpha-2-glycoprotein (lrg). A.AGAFQGLR.Q 2 2.665 0.203 O, P 10/2001 A.LGHLDLSGNR.L 2 2.558 0.279 F.NLTHLPANLLQG.A 1 2.162 0.095 K.ALGHLDLSGNR.L 1 2.790 0.282 2 3.167 0.263 K.DLLLPQPDLR.Y 2 3.175 0.090 K.ENQLEVLEVSWLHGLK.A 2 4.858 0.391 K.LQELHLSSNGL.E 1 1.802 0.100 K.LQELHLSSNGLESLSPEFLR.P 2 2.466 0.184 K.LQELHLSSNGLESLSPEFLRPVPQ.L 3 3.714 0.225 K.LQELHLSSNGLESLSPEFLRPVPQL.R 3 3.758 0.276 K.LQELHLSSNGLESLSPEFLRPVPQLR.V 3 4.810 0.451 R.LHLEGNK.L 1 2.135 0.186 R.LHLEGNKLQVLGK.D 2 2.723 0.311 R.NALTGLPPGLFQASATLDTLVLK.E 2 4.057 0.419 3 4.896 0.466 R.TLDLGENQLETLPPDLLR.G 2 4.042 0.383 R.VAAGAFQGLR.Q 2 3.462 0.304 V.AAGAFQGLR.Q 2 2.849 0.210 P02765 homo sapiens (human). alpha-2-hs-glycoprotein precursor SW:A2HS_HUMAN D.APPSPPLGAPGLPPAGSPPDSH.V 2 4.037 0.476 A, G, O, P (fetuin-a) (alpha-2-z-globulin) (ba- alpha-2-glycoprotein). 10/2001 D.APPSPPLGAPGLPPAGSPPDSHVLLAA 3 4.988 0.461 PPGHQLHR.A D.PDAPPSPPLGAPGLPPAGSPPDSHVLL 3 4.058 0.385 AAPPGHQLHR.A D.PETEEAALVAIDYINQNLPWGYK.H 2 2.600 0.345 D.SHVLLAAPPGHQLHR.A 3 3.582 0.390 F.MGVVSLGSPSGEVSHPR.K 2 4.133 0.469 G.VVSLGSPSGEVSHPR.K 2 2.402 0.193 H.TLNQIDEVK.V 2 2.685 0.184 H.VLLAAPPGHQLHR.A 2 3.317 0.371 K.FSVVYAK.C 1 2.157 0.112 2 2.368 0.123 K.HTLNQIDEVK.V 1 2.759 0.241 2 3.876 0.262 L.GSPSGEVSHPR.K 2 2.811 0.303 P.HGPGLIYR.Q 2 2.943 0.213 R.HTFMGVVSLGSPSGEVSHPR.K 2 6.091 0.501 3 6.242 0.444 R.TVVQPSVGAA.A 1 2.277 0.319 S.APHGPGLIYR.Q 1 2.082 0.201 S.LGSPSGEVSHPR.K 2 2.886 0.299 S.PSGEVSHPR.K 2 3.036 0.298 P01023 homo sapiens (human). SW:A2MG_HUMA IPI:IPI00032256.1 alpha-2-macroglobulin precursor A.IGYLNTGYQR.Q 2 3.463 0.352 A, G, O, P N (97%) (alpha-2-m). 10/2001 A.QWQSFQLEGGLK.Q 2 3.204 0.368 A.SVSGKPQYMVLVPSLLHTETTEK.G 2 4.768 0.423 3 5.342 0.356
Supplementary Table 1 164 A.VLPTGDVIGDSAK.Y 2 2.644 0.253 A.YITIALLEIPLTVTHPVVR.N 3 4.450 0.389 A.YLTAQPAPTSEDLTS.A 2 3.368 0.416 A.YLTAQPAPTSEDLTSATNIVK.W 2 4.157 0.399 C.GTEVPSVPEHGR.K 2 2.555 0.174 D.LLAYAFALAGNQDK.R 2 3.373 0.376 E.AHHTAYLVFSPSK.S 1 2.532 0.279 E.DSLVFVQTDK.S 1 1.977 0.181 E.QNMVLFAPNIY.V 2 3.246 0.340 F.FVELTMPYSVIR.G 2 3.505 0.196 F.PLSSEPFQGSYK.V 1 1.846 0.105 2 2.517 0.263 F.SFPLSSEPFQGSYK.V 2 2.964 0.261 F.SPSQSLPASHAHLR.V 2 3.760 0.405 F.SSTQDTVVALHALSK.Y 2 4.201 0.408 F.YESDVMGR.G 2 2.758 0.180 G.FYESDVMGR.G 1 2.192 0.148 2 3.630 0.431 G.IVRTGTHGLLVK.Q 2 2.343 0.241 G.KPQYMVLVPSLLHTETTEK.G 2 3.573 0.397 3 5.417 0.372 G.YLNTGYQR.Q 2 2.731 0.301 H.YDGSYSTFGER.Y 2 3.422 0.392 I.AQWQSFQLEGGLK.Q 2 2.429 0.185 I.GYLNTGYQR.Q 2 2.932 0.338 I.PFFGQVR.L 1 1.870 0.192 I.PLVYIQDPK.G 2 2.824 0.211 K.AAQVTIQSSGTFSSK.F 1 2.211 0.222 2 4.868 0.439 K.AIGYLNTGY.Q 1 1.829 0.179 K.AIGYLNTGYQ.R 1 2.156 0.137 2 3.057 0.355 K.AIGYLNTGYQR.Q 1 2.177 0.119 2 3.673 0.283 K.ALLAYAFALAGNQDK.R 1 3.890 0.476 2 5.676 0.421 K.ALLAYAFALAGNQDKR.K 2 4.714 0.428 K.APVGHFYEPQAPSAEVEMTS.Y 2 3.754 0.382 K.APVGHFYEPQAPSAEVEMTSY.V 2 3.984 0.366 K.APVGHFYEPQAPSAEVEMTSYVLLAYL 3 3.770 0.260 TAQPAPTSEDLTSATNIVK.W K.ATVLNYLPK.C 2 2.539 0.134 K.DMYSFLEDMGLK.A 1 3.609 0.410 2 4.632 0.331 K.DNSVHWER.P 2 2.794 0.315 K.DNSVHWERPQK.P 2 2.507 0.207 K.DNSVHWERPQKPK.A 2 3.784 0.387 K.DTVIKPLLVEPEGL.E 1 2.484 0.307 2 3.459 0.250 K.DTVIKPLLVEPEGLEK.E 1 4.335 0.400 2 4.887 0.272 3 4.863 0.311 K.FEVQVTVPK.I 2 3.072 0.228 K.FQVDNNNR.L 2 2.418 0.112 K.FRVVSMDENFHPLNELIPLVYIQDPK.G 3 5.672 0.463 K.FRVVSMDENFHPLNELIPLVYIQDPKGN 3 3.764 0.335 R.I K.GGIVRTGTHGLLVK.Q 2 2.487 0.254 K.GGVEDEVTLSAYITIALLEIPLTVTHPVV 3 4.678 0.502 R.N K.GHFSISIPVK.S 1 2.454 0.281 2 3.150 0.302 K.GHFSISIPVKSDIAPVAR.L 2 4.998 0.427 3 5.124 0.416
Supplementary Table 1 165 K.GHFSISIPVKSDIAPVARLLIYAVLPTGD 3 5.032 0.380 VIGDSAK.Y K.GPTQEFK.K 1 2.002 0.090 K.GPTQEFKK.R 2 2.343 0.236 K.GPTQEFKKR.T 2 2.871 0.168 K.GVPIPNKVIFIR.G 2 2.804 0.249 K.HYDGSYSTFGER.Y 1 3.208 0.367 2 4.123 0.468 K.KDNSVHWER.P 2 3.263 0.368 K.KDNSVHWERPQKPK.A 2 3.793 0.360 3 3.753 0.364 K.KLSFYYLIMAK.G 2 2.930 0.266 K.KSGGRTEHPFTVEEFVLPK.F 3 4.289 0.363 K.LHTEAQIQEEGTVVELTGR.Q 2 6.929 0.467 3 5.375 0.425 K.LPPNVVEES.A 1 1.889 0.122 K.LPPNVVEESAR.A 1 2.609 0.234 2 2.999 0.283 K.LSFYYLIMAK.G 2 2.319 0.162 K.MVSGFIPLKPTVK.M 1 3.187 0.308 2 3.876 0.368 K.NEDSLVFVQTDK.S 1 3.253 0.271 2 4.844 0.417 K.NEDSLVFVQTDKSIYKPGQTVK.F 2 3.927 0.357 3 4.355 0.389 K.NEDSLVFVQTDKSIYKPGQTVKFR.V 3 3.622 0.314 K.PDAELSASSVYNLLPEK.D 2 4.872 0.520 K.PLLVEPEGLEK.E 2 3.351 0.211 K.PQYMVLVPSLLHTETTEK.G 2 3.947 0.324 3 5.241 0.310 K.QFSFPLSSEPFQ.G 2 2.853 0.265 K.QFSFPLSSEPFQGSYK.V 1 2.906 0.168 2 4.565 0.368 K.QQNAQGGFSSTQDTVVALHAL.S 2 4.881 0.479 K.QQNAQGGFSSTQDTVVALHALS.K 2 4.369 0.415 K.QQNAQGGFSSTQDTVVALHALSK.Y 2 4.442 0.469 3 4.664 0.457 K.QQNAQGGFSSTQDTVVALHALSKYGA 3 4.295 0.338 ATFTR.T K.RKEYEMK.R 2 2.378 0.185 K.SGGRTEHPFTVEEFVLPK.F 2 4.099 0.421 3 4.321 0.244 K.SIYKPGQTVK.F 1 2.191 0.165 2 2.628 0.201 K.SKAIGYLNTGYQR.Q 2 3.750 0.304 K.SLNEEAVKK.D 2 2.530 0.102 K.SLNEEAVKKDNSVHWERPQKPK.A 3 4.407 0.340 K.SSSNEEVMFLTVQVK.G 1 2.545 0.269 2 4.627 0.468 K.TAQEGDHGSHVYTK.D 1 3.475 0.398 2 4.247 0.483 K.VDLSFSPSQSLPASH.A 2 3.754 0.365 K.VDLSFSPSQSLPASHAH.L 1 2.866 0.408 2 3.564 0.387 3 3.825 0.347 K.VDLSFSPSQSLPASHAHL.R 2 2.860 0.231 K.VDLSFSPSQSLPASHAHLR.V 2 4.920 0.504 3 4.072 0.308 K.VSNQTLSLFFTVLQDVPVR.D 2 4.682 0.414 3 4.172 0.281 L.LAYLTAQPAPTSEDLTSATNIVK.W 2 4.781 0.410 L.LIYAVLPTGDVIGDSAK.Y 2 3.015 0.251 L.PPNVVEESAR.A 2 3.359 0.356 L.PTGDVIGDSAK.Y 1 2.754 0.323 Supplementary Table 1 166 L.SLFFTVLQDVPVR.D 2 3.848 0.402 L.SSEPFQGSYK.V 2 2.986 0.404 L.TAQPAPTSEDLTSATNIVK.W 2 3.667 0.534 L.VHVEEPHTETVR.K 2 3.464 0.319 M.VLVPSLLHTETTEK.G 1 2.019 0.177 2 2.686 0.292 M.VSGFIPLKPTVK.M 2 3.215 0.312 N.EDSLVFVQTDK.S 2 3.491 0.359 N.FHPLNELIPLVYIQDPK.G 2 2.633 0.359 N.GITYTPVSSTNEK.D 2 3.169 0.300 N.KVDLSFSPSQSLPASHAHLR.V 2 4.706 0.530 3 5.036 0.390 N.SAGVAEVGVTVPDTITEWK.A 2 4.506 0.410 Q.FSFPLSSEPFQGSYK.V 2 2.629 0.320 Q.IQEEGTVVELTGR.Q 2 4.880 0.375 Q.YMVLVPSLLHTETTEK.G 2 4.156 0.387 R.AFQPFFVELTMPY.S 2 3.097 0.229 R.AFQPFFVELTMPYSVIR.G 2 4.589 0.435 R.ASVSVLGDILGSAMQN.T 2 2.875 0.123 R.ASVSVLGDILGSAMQNTQN.L 2 3.327 0.323 R.AVDQSVLLMKPDAELSA.S 2 3.974 0.193 R.AVDQSVLLMKPDAELSAS.S 2 3.512 0.196 R.AVDQSVLLMKPDAELSASSVYN.L 2 4.913 0.391 R.AVDQSVLLMKPDAELSASSVYNLLPEK. 2 4.163 0.372 D 3 3.844 0.223 R.AYIFIDEAHITQA.L 2 3.873 0.382 R.AYIFIDEAHITQALIWLSQR.Q 3 3.776 0.272 R.HNVYINGITYTPVSSTN.E 2 2.904 0.140 R.HNVYINGITYTPVSSTNEK.D 2 5.991 0.455 3 5.339 0.326 R.HNVYINGITYTPVSSTNEKDMYSFLED 3 5.890 0.378 MGLK.A R.IAQWQSFQLEGGLK.Q 1 3.400 0.336 2 4.548 0.448 R.IAQWQSFQLEGGLKQFSFPLSSEPFQ 3 6.796 0.525 GSYK.V R.KDTVIKPLLVEPEGL.E 2 2.730 0.323 R.KDTVIKPLLVEPEGLEK.E 2 5.229 0.432 3 4.385 0.297 R.KEYEMK.R 2 2.245 0.148 R.KYFPETWIWDLVVVNSAGVAEVGVTV 3 3.631 0.286 PDTITEWK.A R.LLIYAVLPTGDVIGD.S 2 3.764 0.256 R.LLIYAVLPTGDVIGDSAK.Y 1 3.692 0.439 2 4.480 0.410 R.LLLQQVSLPELPGEYSMK.V 2 4.379 0.300 3 3.887 0.185 R.LVDGKGVPIPNK.V 2 3.069 0.178 R.LVDGKGVPIPNKVIFIR.G 3 3.917 0.357 R.LVHVEEPHTETVR.K 1 3.419 0.306 2 3.396 0.272 R.LVHVEEPHTETVRK.Y 2 3.766 0.273 R.NQGNTWLTAFVLK.T 2 4.389 0.399 R.QGIPFFGQVR.L 2 3.141 0.257 R.QSSEITRTITKLSFVKVDSHFRQGIPFF 3 3.813 0.243 GQVR.L R.QTVSWAVTPK.S 1 2.000 0.088 2 3.143 0.380 R.SASNMAIVDVK.M 1 2.580 0.257 2 3.471 0.238 R.SASNMAIVDVKMVSGFIPLKPTVK.M 3 4.470 0.420 R.SSGSLLNNAIK.G 1 2.093 0.226 2 3.147 0.181 R.TEHPFTVEEFVLPK.F 1 3.223 0.218 Supplementary Table 1 167 2 4.444 0.389 3 4.541 0.280 R.TEHPFTVEEFVLPKFEVQVTVPK.I 3 4.325 0.279 R.TEVSSNHVLIYLDK.V 1 3.004 0.260 2 5.252 0.363 R.TGTHGLLVK.Q 1 1.914 0.154 2 2.278 0.145 R.TGTHGLLVKQEDMK.G 2 3.677 0.391 R.TITKLSFVKVDSHFR.Q 3 4.099 0.364 R.TTVMVK.N 1 1.859 0.193 R.TTVMVKNEDSLVFVQTDK.S 2 2.831 0.277 R.TTVMVKNEDSLVFVQTDKSIYKPGQTV 3 4.555 0.362 K.F R.VGFYESDVMGR.G 1 2.856 0.382 2 4.144 0.455 R.VSVQLEASPAFLAVPVEK.E 1 3.200 0.196 2 4.924 0.389 R.VTAAPQSVCALR.A 2 2.470 0.304 R.VVSMDENFHPLNELIPLVYIQDPK.G 2 3.791 0.359 3 5.506 0.194 R.YGAATFTR.T 2 2.775 0.235 S.AGVAEVGVTVPDTITEWK.A 2 2.699 0.331 S.LLHTETTEK.G 1 2.595 0.236 S.PSQSLPASHAHLR.V 2 2.793 0.290 T.AQPAPTSEDLTSATNIVK.W 2 2.901 0.427 V.GFYESDVMGR.G 1 2.228 0.263 2 3.345 0.267 V.HVEEPHTETVR.K 2 3.218 0.264 V.LPTGDVIGDSAK.Y 1 2.140 0.270 V.SMDENFHPLNELIPLVYIQDPK.G 2 2.684 0.136 Y.AVLPTGDVIGDSAK.Y 2 2.638 0.383 Y.DGSYSTFGER.Y 2 3.057 0.247 Y.LTAQPAPTSEDLTSATNIVK.W 2 4.196 0.418 Y.VLLAYLTAQPAPTSEDLTSATNIVK.W 2 5.235 0.371 Q9y2t2 homo sapiens (human). adapter-related protein complex 3 mu SW:A3M1_HUMAN 1 subunit (mu-adaptin 3a) (ap-3 V.KYTNNEAYFDVVEEIDAII.D 2 2.905 0.084 G adapter complex mu3a subunit). 10/2001 Q9y6b7 homo sapiens (human). adapter-related protein complex 4 IPI:IPI00002150.1 SW:A4B1_HUMAN beta 1 subunit (beta subunit of ap- 4) P.GNSEMQISVKQNEARTETLNSFISV.L 2 2.672 0.107 G, P (97%) (ap-4 adapter complex beta subunit). 10/2001 S.FISVLETVI.G 1 2.604 0.112 P01011 homo sapiens (human). IPI:IPI00032215.1 SW:AACT_HUMAN alpha-1-antichymotrypsin precursor A.KWEMPFDPQDTHQSR.F 3 3.811 0.182 A, G, O, P (97%) (act). 10/2001 C.HPNSPLDEENLTQENQDR.G 2 4.336 0.345 3 5.549 0.234 F.ATDFQDSAAAKK.L 2 2.421 0.362 F.LMIIVPTDTQNIFFMSK.V 2 3.698 0.233 H.PNSPLDEENLTQENQDR.G 2 3.209 0.361 I.TLLSALVETR.T 2 3.295 0.147 K.ADLSGITGAR.N 1 1.819 0.154 2 3.574 0.348 K.AKWEMPFDPQDTHQSR.F 2 3.772 0.345 3 4.158 0.384 K.AVLDVFEEGTEASAATAVK.I 1 3.469 0.405 2 6.048 0.477 3 4.448 0.327 K.EQLSLLDRFTEDAK.R 2 3.662 0.304 K.ITLLSALVETR.T 2 4.325 0.385 K.KLINDYVK.N 1 2.087 0.162 2 3.111 0.159 K.MEEVEAMLLPETLKR.W 2 3.621 0.311 Supplementary Table 1 168 3 3.662 0.301 K.NVIFSPLSISTAL.A 2 3.571 0.411 K.NVIFSPLSISTALAF.L 2 4.094 0.464 K.RLYGSEAFATDFQDSAAAK.K 2 5.646 0.510 3 4.689 0.368 K.RLYGSEAFATDFQDSAAAKK.L 3 5.837 0.355 K.WEMPFDPQDTHQSR.F 2 3.450 0.432 L.YGSEAFATDFQDSAAAK.K 2 4.538 0.552 M.IIVPTDTQNIFFMSK.V 2 3.536 0.410 N.SPLDEENLTQENQDR.G 2 5.195 0.384 P.NSPLDEENLTQENQDR.G 1 2.262 0.158 2 5.140 0.284 R.DYNLNDILLQLGIEEAFTSK.A 2 6.211 0.503 3 5.923 0.459 R.EIGELYLPK.F 1 2.293 0.164 2 2.761 0.208 R.FNRPFLMIIVPTDTQNIFFMSK.V 3 4.843 0.283 R.FTEDAKR.L 1 1.877 0.189 R.GTHVDLGLASANVDFAFSLYK.Q 2 2.880 0.262 R.LYGSEAFATDFQDSAAAK.K 1 2.455 0.221 2 5.622 0.491 R.LYGSEAFATDFQDSAAAKK.L 2 5.129 0.568 R.NLAVSQVVHK.A 1 2.747 0.160 2 3.260 0.215 R.WRDSLEFR.E 2 2.915 0.109 W.RDSLEFR.E 2 2.632 0.159 Q9ugj0 homo sapiens (human). 5'- SW:AAKH_HUMA amp-activated protein kinase, gamma- R.AAPLWESKKQ.S 2 2.587 0.150 O N 2 subunit (ampk gamma-2 chain) (ampk gamma2) (h91620p). 10/2001 O00213 homo sapiens (human). amyloid beta a4 precursor protein- SW:ABB1_HUMAN D.HSKLVDVPFQV.E 1 2.462 0.178 G, O binding family b member 1 (fe65 protein). 10/2001 2 2.711 0.177 V.AKPVGVDVINGALESVLSSS.S 2 2.614 0.090 Q9bzc7 homo sapiens (human). atp- binding cassette, sub-family a, L.LPQGACTGRTPGPPASGAGGAANGTG IPI:IPI00221363.1 SW:ABC2_HUMAN member 2 (atp-binding cassette 2 2.457 0.126 A, G, P AGAVMGPNATAE.E (93%) transporter 2) (atp-binding cassette 2). 10/2001 L.LRPRSAPTELRALVADEPEDLDTEDEG 3 3.813 0.100 LISFE.E R.TILLSTHHMDEADLLG.D 1 2.009 0.091 Q15911 homo sapiens (human). alpha-fetoprotein enhancer binding SW:ABF1_HUMAN A.ARSHLKSLCFF.G 1 2.021 0.229 G protein (at motif-binding factor) (at- binding transcription factor 1). 10/2001 Q9ug63 homo sapiens (human). atp- binding cassette, sub-family f, member IPI:IPI00071545.4 SW:ABF2_HUMAN L.TKELEDFEMKKAAARAVTGVLA.S 2 2.478 0.203 A, O 2 (iron inhibited abc transporter 2). (94%) 10/2001 T.KELEDFEMKK.A 1 2.533 0.122 P45844 homo sapiens (human). atp- binding cassette, sub-family g, IPI:IPI00186858.1 SW:ABG1_HUMAN member 1 (white protein homolog) S.SNMEATETDLLNGHLK.K 2 2.929 0.183 A (93%) (atp-binding cassette transporter 8). 10/2001 Q9unq0 homo sapiens (human). atp- binding cassette, sub-family g, IPI:IPI00009331.2 SW:ABG2_HUMAN member 2 (placenta-specific atp- L.DKVADSKVGTQF.I 1 2.021 0.098 G (97%) binding cassette transporter) (breast cancer resistance protein). 10/2001 P42684 homo sapiens (human). tyrosine-protein kinase abl2 (ec IPI:IPI00218328.1 SW:ABL2_HUMAN S.NTFSIK.K 1 1.816 0.115 G 2.7.1.112) (tyrosine kinase arg). (92%) 10/2001 Q12979 homo sapiens (human). IPI:IPI00183881.1 SW:ABR_HUMAN active breakpoint cluster region- T.LEVDSFGYFVSKAKTRV.F 2 2.836 0.157 G (99%) related protein. 10/2001
Supplementary Table 1 169 P35249 homo sapiens (human). activator 1 37 kda subunit (replication SW:AC12_HUMAN factor c 37 kda subunit) (a1 37 kda A.TRLTGGKEITEKVITDI.A 2 3.439 0.114 G, O subunit) (rf-c 37 kda subunit) (rfc37). 10/1996 P35251 homo sapiens (human). activator 1 140 kda subunit (replication factor c large subunit) (a1 140 kda SW:AC15_HUMAN K.QNWSLLPAQAIYASVLPGE.L 2 2.861 0.107 P subunit) (rf-c 140 kda subunit) (activator 1 large subunit) (dna-binding protein p R.KFFGVIPSGKKLVSETVKKNEKTKSDE 3 3.661 0.105 ETLKAKKGI.K Q09428 homo sapiens (human). K.ALVSVQKLSEFLSSAEIREEQCAPHEPT IPI:IPI00219696.1 SW:ACC8_HUMAN 3 3.549 0.087 A sulfonylurea receptor 1. 10/2001 PQG.P (92%) Q9upn3 homo sapiens (human). actin cross-linking family protein 7 IPI:IPI00100552.1 SW:ACF7_HUMAN (macrophin) (trabeculin-alpha) (620 E.DSRVLSEQLSQQ.T 2 3.097 0.114 A, G, P (99%) kda actin-binding protein) (abp620). 10/2001 G.NELLESSAGDDA.S 2 2.607 0.202 V.DVIVR.S 1 1.887 0.148 W.QDNALRIAEQEHT.Q 2 2.777 0.155 P08912 homo sapiens (human). SW:ACM5_HUMA muscarinic acetylcholine receptor m5. R.TPKRAGIMIGLAWLISFIL.W 2 2.410 0.150 G, P N 10/2001 S.YHNATTVNGTPV.N 2 2.629 0.107 Q99798 homo sapiens (human). SW:ACON_HUMA aconitate hydratase, mitochondrial IPI:IPI00017855.1 D.NISNNLLIGAINIENGKANSVR.N 2 2.333 0.155 P N precursor (ec 4.2.1.3) (citrate hydro- (98%) lyase) (aconitase). 10/2001 F.VTSPEIVTALAIAGTLKF.N 2 2.553 0.268 L.CQRAKVAMSHFEPNEYIH.Y 2 2.621 0.170 P02571 homo sapiens (human), mus musculus (mouse), rattus norvegicus SW:ACTG_HUMA (rat), bos taurus (bovine), trichosurus IPI:IPI00021439.1 K.DLYANTVLSGGTTMYPGIADR.M 2 4.512 0.342 O, P N vulpecula (brush-tailed possum), and (98%) anser anser anser (western graylag goose). K.DSYVGDEAQSK.R 2 2.985 0.290 K.DSYVGDEAQSKR.G 2 2.699 0.304 R.HQGVMVGMGQK.D 2 3.128 0.376 R.VAPEEHPVLLTEAPLNPK.A 2 3.610 0.451 P12718 homo sapiens (human), mus musculus (mouse), rattus norvegicus SW:ACTH_HUMA IPI:IPI00008603.1 (rat), and gallus gallus (chicken). actin, K.SYELPDGQVITIGNER.F 2 4.501 0.365 O, P N (99%) gamma-enteric smooth muscle (alpha- actin 3). 10/2001 P02568 homo sapiens (human), mus musculus (mouse), rattus norvegicus (rat), oryctolagus cuniculus (rabbit), IPI:IPI00025416.1 SW:ACTS_HUMAN K.YPIEHGIITNWDDMEK.I 2 4.095 0.287 O sus scrofa (pig), bos taurus (bovine), (98%) and gallus gallus (chicken). actin, alpha P42024 homo sapiens (human), mus musculus (mouse), and canis familiaris (dog). alpha-centractin SW:ACTZ_HUMAN S.EFEIVK.A 1 1.907 0.108 A (centractin) (centrosome-associated actin homolog) (actin-rpv) (arp1). 10/2001 Q03154 homo sapiens (human). aminoacylase-1 (ec 3.5.1.14) (n-acyl-l- SW:ACY1_HUMAN R.VTSTGRPGHAS.R 1 2.337 0.198 G amino-acid amidohydrolase) (acy-1). 10/2001 P78325 homo sapiens (human). adam 8 precursor (ec 3.4.24.-) (a disintegrin SW:AD08_HUMAN and metalloproteinase domain 8) (cell A.SRYRADMCGVLQCKGGQ.Q 2 2.482 0.186 P surface antigen ms2) (cd156a antigen) (cd156). 10/2001 P.TTHPGQPARHPASSVALKR.P 2 2.610 0.201 O00116 homo sapiens (human). alkyldihydroxyacetonephosphate SW:ADAS_HUMA IPI:IPI00010349.1 synthase, peroxisomal precursor (ec A.DRDRDPDPDR.A 1 2.047 0.187 G N (97%) 2.5.1.26) (alkyl-dhap synthase) (alkylglycerone-phosphate synthase). Supplementary Table 1 170 10/2001 Q06278 homo sapiens (human). IPI:IPI00029715.1 SW:ADO_HUMAN aldehyde oxidase (ec 1.2.3.1). G.PEVKFK.G 1 2.115 0.130 G, P (98%) 10/2001 P55197 homo sapiens (human). af-10 IPI:IPI00183388.1 SW:AF10_HUMAN T.SSVASAAGSITSSSLQK.S 2 2.998 0.174 A protein. 10/2001 (95%) P55198 homo sapiens (human). af-17 IPI:IPI00183364.1 SW:AF17_HUMAN G.PPVLTAQTNPFLSLSGAEGSGGGPK.G 2 2.542 0.150 A, O, P protein. 10/2001 (97%) K.MKTSRHSSGGGGGGAGGGGGSMGG 2 2.874 0.199 GGSGFISGR.R P55196 homo sapiens (human). af-6 IPI:IPI00216504.1 SW:AF6_HUMAN K.KQNGMGLSIVAAKGAGQDKLGIYVK.S 2 2.504 0.200 A, O, P protein. 10/2001 (93%) N.QPPSPGGKSAYASGTTAKITSVST.G 2 3.124 0.212 R.NIPNGLQEFLDPLCQRGF.C 2 2.418 0.115 P43652 homo sapiens (human). SW:AFAM_HUMA IPI:IPI00019943.1 afamin precursor (alpha-albumin) K.IAPQLSTEELVSLGEK.M 1 2.800 0.253 O, P N (97%) (alpha-alb). 10/2001 2 4.254 0.471 K.LPNNVLQEK.I 1 2.849 0.115 K.SDVGFLPPFPTLDPEEK.C 1 1.980 0.281 2 3.515 0.396 R.DADPDTFFAK.F 1 2.438 0.160 2 2.856 0.107 R.ESLLNHFLYEVAR.R 2 4.210 0.348 R.RHPDLSIPELLR.I 2 3.792 0.363 O15123 homo sapiens (human). SW:AGP2_HUMAN angiopoietin-2 precursor (ang-2). S.ISQPGNDFSTKDGDNDKCICK.C 2 2.763 0.144 O, P 10/2001 Q09666 homo sapiens (human). SW:AHNK_HUMA neuroblast differentiation associated IPI:IPI00021812.1 D.ADVSVPKLEGDLTGPSVGVEVPDV.E 2 2.404 0.200 A, O, P N protein ahnak (desmoyokin) (94%) (fragments). 10/2001 D.VTVPKLEGELKGPKVDIDAPDVDVHGP 3 3.591 0.172 DWHLKMPK.M G.LEGKLKGPQITGPSLEGDLGLKGAKPQ 2 2.488 0.101 GHIGVDA.S K.GPKFKMPEMNIKVPK.I 2 2.994 0.091 Q9y4k1 homo sapiens (human). K.AWGGYNGELQSLRPILGDFSNAHMIM IPI:IPI00045122.1 SW:AIM1_HUMAN absent in melanoma 1 protein. 3 4.011 0.160 G YSEKNFGS.K (96%) 10/2001 O00170 homo sapiens (human). ah receptor-interacting protein (aip) SW:AIP_HUMAN V.VLYPLVAKSLRNIAVGKDPLEGQR.H 2 2.973 0.091 P (immunophilin homolog ara9) (hbv-x associated protein 2). 10/2001 Q9uka4 homo sapiens (human). a- kinase anchor protein 11 (protein K.SFSEDVFQSVKSLLQSQKELCSVTAED IPI:IPI00161614.1 SW:AK11_HUMAN kinase a anchoring protein 11) 3 3.902 0.106 A CLQ.Q (93%) (prka11) (a kinase anchor protein 220 kda) (akap 220) (hakap220). 10/2001 L.PSVKTSVTTSISEPWTQR.S 2 2.203 0.131 P.IRSSAFSPLGGCTPAECFCQTDIGGDR. 2 2.444 0.195 I Q92667 h a kinase anchor protein 1, mitochondrial precursor (protein kinase a anchoring protein 1) (prka1) SW:AKA1_HUMAN A.SQLQGQKEESCVPVHQK.T 2 2.450 0.117 G, O (a-kinase anchor protein 149 kda) (akap 149) (dual specificity a-kinase anchoring P.KKVDLIIWEIEVPK.H 1 2.706 0.129 O43823 homo sapiens (human). a- kinase anchor protein 8 (a-kinase SW:AKA8_HUMAN P.FTSETVDPEMEGDDNLGGEDK.K 2 2.726 0.100 O anchor protein 95 kda) (akap 95). 10/2001 Q99996 h a-kinase anchor protein 9 (protein kinase a anchoring protein 9) (prka9) (a-kinase anchor protein 450 Q.FTEKIEKMQELHAAEILDMESRHISETE IPI:IPI00064605.1 SW:AKA9_HUMAN 3 3.585 0.155 G, O kda) (akap 450) (a-kinase anchor TLKR.E (98%) protein 350 kda) (akap 350) (hgakap 350) (ak Q.NGNETQGEGEEQTFKEK.E 2 2.515 0.171 P24298 homo sapiens (human). alanine aminotransferase (ec 2.6.1.2) IPI:IPI00217458.1 SW:ALAT_HUMAN F.LLADEVYQ.D 1 2.187 0.112 A (glutamic--pyruvic transaminase) (gpt) (92%) (glutamic--alanine transaminase). Supplementary Table 1 171 10/2001 P02768 homo sapiens (human). SW:ALBU_HUMAN -.DAHKSEVAHR.F 1 2.203 0.191 A serum albumin precursor. 10/2001 2 2.986 0.324 -.DAHKSEVAHRFK.D 2 3.196 0.297 -.DAHKSEVAHRFKDLGEEN.F 2 4.297 0.428 -.DAHKSEVAHRFKDLGEENFK.A 2 3.628 0.320 3 3.822 0.405 A.ADFVESK.D 1 2.032 0.085 A.DFVESK.D 1 2.264 0.105 A.DLPSLAADFVESK.D 1 3.056 0.437 2 3.035 0.463 A.EFAEVSK.L 1 2.253 0.153 A.EVENDEMPADLPSLAADFVESK.D 2 2.582 0.197 A.FHDNEETFLK.K 2 2.614 0.190 A.HKSEVAHR.F 2 2.333 0.152 A.KTCVADESAENCDK.S 2 2.292 0.173 A.KVFDEFKPLVEEPQNLIK.Q 2 4.773 0.346 3 5.054 0.366 A.LEVDETYVPK.E 2 2.570 0.159 A.PELLFFAK.R 1 2.706 0.219 A.SQAALGL.- 1 2.051 0.175 A.VMDDFAAFVEK.C 1 2.848 0.329 2 4.458 0.455 C.CKHPEAK.R 2 2.373 0.135 C.ELFEQLGEYK.F 2 2.681 0.204 C.FLQHKDDNPNLPR.L 2 3.847 0.358 C.FSALEVDETYVPK.E 1 2.064 0.256 2 4.070 0.362 C.TAFHDNEETFLK.K 2 3.572 0.383 C.TESLVNR.R 1 1.953 0.209 D.DFAAFVEK.C 1 2.937 0.236 D.EFKPLVEEPQNLIK.Q 1 3.308 0.200 2 3.612 0.301 D.ELRDEGKASSAK.Q 2 3.030 0.218 D.EMPADLPSLAADFVESK.D 1 3.575 0.425 2 3.713 0.334 3 4.236 0.188 D.ETYVPK.E 1 1.908 0.164 D.FAAFVEK.C 1 2.332 0.146 D.HVKLVNEVTEFAK.T 2 4.640 0.409 D.KSLHTLFGDK.L 1 2.014 0.120 2 2.867 0.246 D.LGEENFK.A 1 2.058 0.170 D.LPSLAADFVESK.D 1 3.641 0.242 2 4.169 0.338 D.NEETFLK.K 1 2.109 0.135 E.CFLQHKDDNPNLPR.L 2 2.319 0.209 E.FAEVSK.L 1 2.087 0.105 E.FKPLVEEPQNLIK.Q 1 3.132 0.185 2 3.301 0.180 E.KPLLEKSHCIAEVENDEMPADLPSLAA 2 2.607 0.189 DFVESK.D E.LFEQLGEYK.F 1 2.293 0.222 E.LLFFAK.R 1 1.810 0.087 E.MPADLPSLAADFVESK.D 2 2.318 0.209 E.NQDSISSK.L 1 1.877 0.141 E.VENDEMPADLPSLAADFVESK.D 2 2.799 0.196 E.VTEFAK.T 1 2.037 0.103 F.DEFKPLVEEPQNLIK.Q 2 4.217 0.379 3 4.550 0.226 F.EQLGEYK.F 1 1.817 0.129 F.HDNEETFLK.K 2 3.409 0.327 F.HDNEETFLKKYLYEIAR.R 2 2.371 0.210 Supplementary Table 1 172 F.KAWAVAR.L 2 2.515 0.164 F.KDLGEENFK.A 1 2.647 0.257 2 3.092 0.229 F.KPLVEEPQNLIK.Q 2 4.151 0.289 F.LQHKDDNPNLPR.L 2 3.623 0.340 F.LYEYAR.R 1 1.986 0.124 F.QNALLVR.Y 2 2.257 0.101 F.SALEVDETYVPK.E 1 1.848 0.204 2 4.163 0.375 F.YAPELLFFAK.R 1 3.081 0.200 2 2.823 0.315 G.MFLYEYAR.R 1 1.925 0.203 2 2.947 0.266 H.KDDNPNLPR.L 2 3.003 0.225 H.PYFYAPELLFFAK.R 1 3.289 0.253 2 3.719 0.318 H.TLFGDK.L 1 2.272 0.156 I.CENQDSISSK.L 1 2.465 0.089 K.AACLLPK.L 1 1.967 0.198 K.AAFTECCQAADK.A 1 2.472 0.254 2 2.789 0.218 K.ADDKETCFAEEGK.K 2 3.466 0.320 K.ADDKETCFAEEGKK.L 2 3.633 0.233 K.AEFAEVSK.L 1 2.377 0.253 2 2.822 0.235 K.AEFAEVSKLVTDLTK.V 1 3.552 0.399 2 5.304 0.425 3 3.756 0.218 K.ALVLIAFAQYLQQCPFEDHVK.L 2 2.783 0.148 K.ATKEQLKAVMDDFAAFVEK.C 3 4.310 0.346 K.AVMDDFAAFVEK.C 1 3.601 0.410 2 4.277 0.376 K.CCKHPEAK.R 1 2.102 0.119 K.DDNPNLPR.L 1 1.971 0.116 2 2.567 0.197 K.DLGEENFK.A 1 2.494 0.225 2 2.506 0.126 K.DVFLGMFLYEYAR.R 1 3.629 0.295 2 4.777 0.358 K.EFNAETFTF.H 2 2.630 0.245 K.EFNAETFTFH.A 1 2.053 0.096 2 2.586 0.265 K.EFNAETFTFHAD.I 1 2.350 0.217 2 3.391 0.294 K.EFNAETFTFHADICTLSEK.E 2 3.360 0.364 K.ETCFAEEGK.K 1 2.164 0.125 K.FGERAFKAWAVAR.L 2 3.487 0.367 K.FQNALLVR.Y 1 2.261 0.098 2 3.105 0.166 K.KLVAASQ.A 1 1.931 0.137 K.KLVAASQA.A 1 2.245 0.111 K.KLVAASQAA.L 1 2.183 0.291 K.KLVAASQAALG.L 1 2.153 0.250 2 2.934 0.297 K.KLVAASQAALGL.- 1 2.611 0.138 2 3.588 0.242 K.KQTALVELVK.H 1 3.171 0.263 2 3.549 0.243 K.KVPQVSTPTL.V 1 2.227 0.204 2 3.077 0.335 K.KVPQVSTPTLVE.V 2 4.289 0.365 K.KVPQVSTPTLVEV.S 2 3.810 0.375 K.KVPQVSTPTLVEVS.R 1 3.010 0.267
Supplementary Table 1 173 2 3.404 0.242 K.KVPQVSTPTLVEVSR.N 1 3.496 0.314 2 3.702 0.187 3 5.063 0.395 K.KVPQVSTPTLVEVSRNLGK.V 3 3.628 0.339 K.KYLYEIAR.R 1 2.790 0.177 2 3.119 0.253 K.KYLYEIARR.H 2 2.336 0.139 K.LDELRDEGK.A 2 3.104 0.166 K.LDELRDEGKASSA.K 2 2.595 0.300 K.LDELRDEGKASSAK.Q 2 4.186 0.361 K.LDELRDEGKASSAKQR.L 2 3.333 0.257 3 4.661 0.429 K.LKECCEKPLLEK.S 2 3.569 0.083 K.LVAASQA.A 1 2.065 0.190 K.LVAASQAA.L 1 2.213 0.159 K.LVAASQAALG.L 2 2.657 0.263 K.LVAASQAALGL.- 1 1.954 0.108 2 4.214 0.349 K.LVNEVTEFAK.T 1 3.192 0.322 2 3.465 0.226 K.LVTDLTK.V 1 2.127 0.115 K.NYAEAK.D 1 2.144 0.087 K.NYAEAKDVFLGMFLYEYAR.R 3 4.404 0.386 K.PLVEEPQNLIK.Q 1 3.174 0.247 2 3.834 0.210 K.QEPERNECFLQHKDDNPNLPR.L 3 4.712 0.401 K.QNCELFEQLGEYK.F 1 2.486 0.126 2 4.253 0.365 K.QTALVELVK.H 2 2.689 0.220 K.QTALVELVKHKPK.A 2 3.582 0.279 K.RMPCAEDYLSVVLNQLCVLHEKTPVSD 3 3.778 0.196 R.V K.RMPCAEDYLSVVLNQLCVLHEKTPVSD 3 3.515 0.175 RVTK.C K.SHCIAEVENDEMPADLPSLAADFVESK. 2 4.118 0.481 D 3 5.392 0.328 K.SLHTLFGD.K 1 1.947 0.136 K.SLHTLFGDK.L 1 3.030 0.319 2 2.714 0.285 K.SLHTLFGDKL.C 1 2.798 0.260 2 3.384 0.403 K.TCVADESAENCDKSLHTLFGDK.L 2 3.318 0.264 3 3.877 0.206 K.TPVSDRVTK.C 2 2.543 0.121 K.TPVSDRVTKCCTESLVNR.R 2 2.597 0.174 3 4.617 0.485 K.TYETTLEK.C 1 1.920 0.080 K.VFDEFK.P 1 2.089 0.111 K.VFDEFKPLVEE.P 2 2.962 0.264 K.VFDEFKPLVEEPQ.N 1 2.847 0.276 2 4.109 0.241 K.VFDEFKPLVEEPQN.L 1 2.481 0.238 2 4.539 0.309 K.VFDEFKPLVEEPQNL.I 1 3.381 0.224 2 4.524 0.348 K.VFDEFKPLVEEPQNLI.K 2 3.825 0.359 K.VFDEFKPLVEEPQNLIK.Q 2 5.267 0.416 3 5.718 0.330 K.VFDEFKPLVEEPQNLIKQ.N 2 4.370 0.405 3 4.598 0.334 K.VFDEFKPLVEEPQNLIKQN.C 2 4.028 0.230 3 4.152 0.365
Supplementary Table 1 174 K.VFDEFKPLVEEPQNLIKQNC.E 2 2.633 0.156 K.VFDEFKPLVEEPQNLIKQNCELFK.Q 2 4.445 0.337 K.VHTECCHGD.L 1 2.139 0.188 K.VHTECCHGDLLECADDR.A 2 3.030 0.114 K.VHTECCHGDLLECADDRADLAKYICEN 3 3.568 0.219 QDSISSK.L K.VPQVSTPTLVEVS.R 1 2.314 0.233 2 2.503 0.185 K.VPQVSTPTLVEVSR.N 1 2.727 0.352 2 3.816 0.419 K.VPQVSTPTLVEVSRNLGK.V 2 3.223 0.432 K.YICENQDSISSK.L 1 2.522 0.262 2 4.269 0.358 K.YLYEIAR.R 1 2.142 0.158 2 2.546 0.247 K.YLYEIARR.H 2 2.363 0.113 L.AADFVESK.D 1 2.125 0.175 L.DELRDEGK.A 1 2.016 0.188 2 2.561 0.145 L.DELRDEGKASSAK.Q 2 2.947 0.324 L.EVDETYVPK.E 2 2.362 0.272 L.FEQLGEYK.F 1 2.495 0.122 L.GMFLYEYAR.R 1 2.330 0.314 2 2.406 0.136 L.HTLFGDK.L 1 2.313 0.225 L.KAVMDDFAAFVEK.C 1 2.532 0.401 2 4.657 0.513 L.KECCEKPLLEK.S 2 3.507 0.109 L.PSLAADFVESK.D 1 3.786 0.417 2 3.847 0.349 L.VAASQAALGL.- 2 2.880 0.094 L.VELVKHKPK.A 2 2.579 0.129 L.VELVKHKPKATKEQLK.A 3 3.613 0.348 L.VNEVTEFAK.T 1 2.622 0.368 2 2.887 0.291 L.VTDLTK.V 1 2.030 0.114 M.CTAFHDNEETFLK.K 2 4.314 0.362 M.CTAFHDNEETFLKK.Y 2 3.457 0.393 M.DDFAAFVEK.C 1 2.862 0.262 M.PADLPSLAADFVESK.D 1 4.023 0.460 2 5.037 0.471 N.DEMPADLPSLAADFVESK.D 2 4.181 0.447 P.CFSALEVDETYVPK.E 2 2.929 0.241 P.DYSVVLLLR.L 2 3.458 0.359 P.ELLFFAK.R 1 2.267 0.169 P.KAEFAEVSK.L 1 2.539 0.292 2 3.422 0.251 P.LLEKSHCIAEVENDEMPADLPSLAADF 2 2.677 0.096 VESK.D 3 4.552 0.088 P.QVSTPTLVEVSR.N 2 3.185 0.231 P.SLAADFVESK.D 1 2.388 0.256 2 2.337 0.297 P.YFYAPELLFFAK.R 1 3.507 0.350 2 4.367 0.465 Q.HKDDNPNLPR.L 2 3.065 0.333 Q.TALVELVK.H 1 2.233 0.157 2 2.726 0.140 Q.VSTPTLVEVSR.N 2 2.367 0.269 R.AFKAWAVAR.L 1 1.952 0.127 2 3.170 0.300 R.ETYGEMADCCAK.Q 1 2.842 0.331 2 3.088 0.214 R.FKDLGEENFK.A 1 3.522 0.225 Supplementary Table 1 175 2 3.777 0.251 R.FPKAEFAEVSK.L 1 2.187 0.276 2 3.790 0.244 R.FPKAEFAEVSKLVTDLTK.V 3 4.220 0.381 R.HPDYSVVLLLR.L 1 2.770 0.184 2 2.984 0.333 R.HPYFYAPEL.L 1 2.156 0.314 2 2.466 0.176 R.HPYFYAPELL.F 1 2.845 0.231 2 2.583 0.198 R.HPYFYAPELLF.F 1 2.508 0.097 R.HPYFYAPELLFF.A 1 1.885 0.233 2 2.844 0.246 R.HPYFYAPELLFFAK.R 1 4.242 0.380 2 3.455 0.240 3 4.804 0.233 R.HPYFYAPELLFFAKR.Y 2 2.480 0.316 3 5.194 0.406 R.LAKTYETTLEK.C 1 2.534 0.221 2 3.181 0.257 R.LSQRFPK.A 2 2.389 0.164 R.LSQRFPKAE.F 2 2.658 0.197 R.LSQRFPKAEFAEVSK.L 2 3.798 0.331 3 5.045 0.394 R.LSQRFPKAEFAEVSKLVTDLTK.V 3 6.948 0.474 R.LVRPEVDVM.C 1 2.137 0.156 R.LVRPEVDVMCTA.F 2 2.462 0.178 R.LVRPEVDVMCTAFHDNEETFLK.K 2 3.396 0.468 3 5.628 0.276 R.LVRPEVDVMCTAFHDNEETFLKK.Y 3 5.705 0.442 R.MPCAEDYLSVVLNQLCVLHEKTPVSDR 3 3.606 0.218 .V R.MPCAEDYLSVVLNQLCVLHEKTPVSDR 3 3.503 0.190 VTK.C R.NECFLQHKDDNPNLPR.L 3 3.628 0.343 R.NLGKVGSK.C 1 2.359 0.143 R.QIKKQTALVELVK.H 2 3.675 0.246 R.RHPDYSVVLL.L 2 2.530 0.274 R.RHPDYSVVLLLR.L 1 2.731 0.323 2 3.990 0.427 3 3.918 0.230 R.RHPDYSVVLLLRLAKTYETTLEK.C 3 4.326 0.387 R.RHPYFYAPEL.L 2 2.827 0.297 R.RHPYFYAPELL.F 1 2.415 0.087 2 2.679 0.121 R.RHPYFYAPELLF.F 1 2.676 0.226 2 3.073 0.286 R.RHPYFYAPELLFF.A 1 3.067 0.245 2 3.155 0.126 R.RHPYFYAPELLFFAK.R 1 3.733 0.343 2 5.124 0.439 3 5.933 0.359 R.RHPYFYAPELLFFAKR.Y 3 5.326 0.315 R.RPCFSALEVDETYVPK.E 2 4.639 0.348 R.VTKCCTESLVNR.R 2 3.068 0.239 R.YKAAFTECCQAADK.A 2 3.583 0.115 R.YTKKVPQVSTPT.L 2 2.658 0.270 R.YTKKVPQVSTPTL.V 2 3.037 0.210 R.YTKKVPQVSTPTLVEVS.R 2 2.999 0.339 R.YTKKVPQVSTPTLVEVSR.N 2 3.887 0.403 3 5.132 0.362 S.ALEVDETYVPK.E 1 1.939 0.081 2 4.084 0.352 S.KLVTDLTK.V 1 2.347 0.205 Supplementary Table 1 176 S.LAADFVESK.D 1 2.549 0.344 S.QRFPKAEFAEVSK.L 2 2.939 0.175 S.TPTLVEVSR.N 1 2.046 0.213 T.AFHDNEETFLK.K 2 3.521 0.401 T.ALVELVK.H 1 2.184 0.123 T.KCCTESLVNRRPCFSALEVDETYVPK.E 3 3.669 0.105 T.KKVPQVSTPTLVEVSR.N 2 3.042 0.424 3 4.635 0.382 T.PTLVEVSR.N 1 2.466 0.242 2 2.258 0.151 T.YETTLEK.C 1 1.869 0.204 V.ADESAENCDK.S 1 2.233 0.189 V.DETYVPK.E 1 2.288 0.088 V.FDEFKPLVEEPQNLIK.Q 2 4.360 0.303 3 4.928 0.320 V.FLGMFLYEYAR.R 2 2.531 0.388 V.KLVNEVTEFAK.T 2 3.140 0.384 V.MDDFAAFVEK.C 1 3.069 0.311 2 3.320 0.256 V.NEVTEFAK.T 1 2.405 0.227 V.PQVSTPTLVEVSR.N 1 2.739 0.303 2 4.114 0.374 Y.APELLFFAK.R 1 2.788 0.264 2 2.816 0.331 Y.FYAPELLFF.A 1 2.180 0.119 2 3.283 0.179 Y.FYAPELLFFAK.R 1 3.272 0.264 2 3.922 0.347 Y.GEMADCCAK.Q 1 1.927 0.116 Y.ICENQDSISSK.L 1 2.631 0.208 Y.KAAFTECCQAADK.A 2 2.541 0.104 Y.KFQNALLVR.Y 2 3.458 0.168 Y.LYEIAR.R 1 2.096 0.086 Y.TKKVPQVSTPT.L 2 2.659 0.242 Y.TKKVPQVSTPTL.V 2 3.207 0.366 Y.TKKVPQVSTPTLVEVSR.N 3 4.599 0.387 P01876 homo sapiens (human). ig IPI:IPI00166866.1 SW:ALC1_HUMAN A.SGVTFTWTPSSGK.S 2 3.516 0.380 A, G, O, P alpha-1 chain c region. 10/2001 (92%) C.MVGHEALPLAFTQK.T 2 3.613 0.359 D.ASGVTFTWTPSSGK.S 2 4.071 0.465 D.YWGQGTLVTVSSASPTSPK.V 2 3.938 0.532 E.PSQGTTTFAVTSILR.V 2 4.676 0.493 F.DYWGQGTLVTVSSASPTSPK.V 2 3.462 0.445 G.FFPQEPLSVTWSESGQGVTAR.N 2 4.016 0.440 G.HEALPLAFTQK.T 2 2.964 0.239 G.KSAVQGPPER.D 2 2.549 0.208 G.TTTFAVTSILR.V 2 2.441 0.126 H.EALPLAFTQK.T 1 2.457 0.328 2 2.803 0.123 K.KGDTFSCMVGHEALPLAFTQK.T 2 3.320 0.362 3 4.822 0.433 K.SAVQGPPER.D 2 2.693 0.291 K.SGNTFRPEVH.L 2 2.705 0.328 K.SGNTFRPEVHLLPPPSEELALNELVTLT 3 4.584 0.169 CLAR.G K.TFTCTAAYPESK.T 2 2.745 0.374 K.TPLTATLSK.S 1 2.260 0.195 2 2.740 0.186 K.VFPLSLCSTQPDGNVVIACLVQGFFPQ 3 4.301 0.170 EPLSVTWSESGQGVTAR.N K.YLTWASR.Q 1 2.036 0.142 2 2.548 0.295 L.SVTWSESGQGVTAR.N 2 4.663 0.433 L.VTVSSASPTSPK.V 1 2.271 0.280
Supplementary Table 1 177 2 3.298 0.396 M.VGHEALPLAFTQK.T 1 3.334 0.416 2 3.674 0.233 P.FDYWGQGTLVTVSSASPTSPK.V 2 2.884 0.271 P.LTATLSK.S 1 1.998 0.197 Q.GFFPQEPLSVTWSESGQGVTAR.N 2 4.403 0.495 Q.GTLVTVSSASPTSPK.V 1 2.738 0.239 2 4.738 0.366 Q.GTTTFAVTSILR.V 2 2.990 0.484 R.DASGVTFTWTPSSGK.S 1 3.764 0.416 2 5.261 0.482 R.EKYLTWASR.Q 1 1.898 0.207 2 2.727 0.294 R.GFSPKDVLVR.W 2 3.180 0.302 R.NFPPSQDASGDLYTTSSQLTLPATQ.C 2 3.322 0.263 R.NFPPSQDASGDLYTTSSQLTLPATQCL 3 3.685 0.218 AGKSVTCHVK.H R.QEPSQGTTTF.A 2 2.603 0.261 R.QEPSQGTTTFAVT.S 2 3.115 0.287 R.QEPSQGTTTFAVTS.I 2 3.242 0.428 R.QEPSQGTTTFAVTSILR.V 1 2.301 0.319 2 4.582 0.485 3 4.359 0.250 R.VAAEDWK.K 1 1.927 0.188 2 2.486 0.179 R.VAAEDWKK.G 2 2.459 0.283 R.WLQGSQELPR.E 1 2.734 0.176 2 4.037 0.323 R.WLQGSQELPREK.Y 1 2.527 0.159 2 3.829 0.290 T.LVTVSSASPTSPK.V 2 2.484 0.414 V.TWSESGQGVTAR.N 2 3.495 0.350 V.VIACLVQGFFPQEPLSVTWSESGQGVT 2 2.454 0.255 AR.N W.GQGTLVTVSSASPTSPK.V 2 3.792 0.345 W.LQGSQELPR.E 2 2.645 0.217 Y.TTSSQLTLPATQCLAGKSVT.C 2 2.510 0.113 Y.WGQGTLVTVSSASPTSPK.V 2 4.560 0.449 P01877 homo sapiens (human). ig IPI:IPI00004641.1 SW:ALC2_HUMAN D.ASGATFTWTPSSGK.S 2 3.493 0.447 G, O, P alpha-2 chain c region. 10/2001 (95%) R.DASGATFTWTPSSGK.S 1 3.111 0.471 2 4.606 0.504 R.NFPPSQDASGDLYTTSSQLTLPATQCP 3 3.637 0.286 DGKSVTCHVK.H R.TYYGMDVWGQGTTVTVSSASPTSPK. 3 3.639 0.253 V P35858 homo sapiens (human). insulin-like growth factor binding SW:ALS_HUMAN A.LGPLQRAFWLDVS.H 1 2.342 0.118 G, O, P protein complex acid labile chain precursor (als). 10/2001 R.AFWLDVSHNR.L 2 3.161 0.340 R.DFALQNPSAVPR.F 2 3.989 0.338 R.LAELPADALGPLQR.A 2 3.764 0.349 R.LEALPNSLLAPLGR.L 2 3.491 0.300 R.NLIAAVAPGAFLGLK.A 2 3.124 0.334 R.TFTPQPPGLER.L 2 2.788 0.130 R.VAGLLEDTFPGLLGLR.V 2 4.305 0.333 P39195 homo sapiens (human). alu IPI:IPI00023544.1 SW:ALU8_HUMAN subfamily sx sequence contamination R.LKKXXXAGGGRARWLTPVIPA.L 2 2.841 0.087 A (91%) warning entry. 10/2001 P02760 homo sapiens (human). ambp protein precursor [contains: alpha-1- SW:AMBP_HUMA microglobulin (protein hc) (complex- A.FIQLWAFDAVK.G 2 3.280 0.261 O, P N forming glycoprotein heterogeneous in charge); inter-alpha- trypsin inhibitor lig K.LYGRAPQLR.E 2 2.277 0.184
Supplementary Table 1 178 R.AFIQLWAFDAVK.G 2 4.577 0.368 R.ETLLQDFR.V 2 2.356 0.193 R.VVAQGVGIPEDSIFTMADR.G 2 4.565 0.366 P19021 homo sapiens (human). peptidyl-glycine alpha-amidating IPI:IPI00219043.1 SW:AMD_HUMAN N.VFAISYIPGLLFAVNGK.P 1 2.881 0.105 G monooxygenase precursor (ec (97%) 1.14.17.3) (pam). 10/2001 Q01433 homo sapiens (human). amp SW:AMD2_HUMA G.SGKPKAKYPFKKRASLQASTAAPEAR. IPI:IPI00215827.1 deaminase 2 (ec 3.5.4.6) (amp 2 2.708 0.194 O N G (98%) deaminase isoform l). 10/2001 Q16671 homo sapiens (human). anti- mullerian hormone type ii receptor SW:AMH2_HUMA precursor (ec 2.7.1.37) (amh type ii G.LFLLLLLLLGSIILALLQRKNY.R 2 2.438 0.255 G N receptor) (mis type ii receptor) (misrii) (mrii). 10/2001 S.IWMALVLLGLFLLLLLLLGSIILA.L 2 2.885 0.115 Q07075 homo sapiens (human). glutamyl aminopeptidase (ec 3.4.11.7) SW:AMPE_HUMA IPI:IPI00014375.1 (eap) (aminopeptidase a) (apa) E.YFAMNYSLPKL.D 1 2.039 0.126 A N (96%) (differentiation antigen gp160). 10/2001 S.LMSSHPIIVTVTTPDEITSVF.D 2 2.452 0.155 P04746 homo sapiens (human). alpha-amylase, pancreatic precursor SW:AMYP_HUMA I.ALECERYLAPKGFGGVQVSPPNENVAI IPI:IPI00174933.1 (ec 3.2.1.1) (1,4-alpha-d-glucan 3 4.187 0.163 A N YNPF.R (98%) glucanohydrolase) (pancreatic alpha- amylase) (pa). 10/2001 P01019 homo sapiens (human). SW:ANGT_HUMA IPI:IPI00032220.1 angiotensinogen precursor [contains: F.AVYDQSATALHFLGR.V 2 3.488 0.376 G, O, P N (97%) angiotensin i; angiotensin ii]. 10/2001 K.ALQDQLVLVAAK.L 1 2.499 0.179 2 4.170 0.341 K.ANAGKPKDPTFIPAPIQAK.T 2 3.688 0.287 3 4.405 0.315 K.DPTFIPAPIQAK.T 1 3.047 0.366 2 3.227 0.213 K.LDTEDKLR.A 2 2.509 0.110 K.PKDPTFIPAPIQAK.T 2 4.096 0.408 K.QPFVQGLALYTPVVLPR.S 2 4.650 0.498 K.VEGLTFQQNSLNWMK.K 2 2.868 0.286 K.VLSALQAVQGLLVAQGR.A 2 4.677 0.284 3 4.973 0.338 R.ADSQAQLLLSTVVGVFTAPGLHLK.Q 3 4.146 0.310 R.FMQAVTGWK.T 1 2.575 0.156 2 2.939 0.272 R.SLDFTELDVAAEK.I 1 2.322 0.258 2 4.095 0.369 R.TIHLTMPQLVLQGSYDLQDLLAQAELP 3 4.673 0.400 AILHTELNLQK.L R.VGEVLNSIFFELEADER.E 2 3.791 0.468 P01008 homo sapiens (human). IPI:IPI00165421.1 SW:ANT3_HUMAN antithrombin-iii precursor (atiii). A.NRPFLVFIR.E 2 3.373 0.247 G, O, P (99%) 10/2001 E.LPFKGDDITMVLILPKPEK.S 2 2.257 0.156 F.RIEDGFSLK.E 2 2.895 0.270 K.AFLEVNEEGSEAAASTAVVIAGR.S 2 6.073 0.481 3 5.015 0.431 K.ANRPFLVFIR.E 2 3.420 0.166 K.ATEDEGSEQKIPEATN.N 2 3.740 0.293 K.ATEDEGSEQKIPEATNR.R 1 2.972 0.300 2 4.329 0.390 3 4.043 0.222 K.ELTPEVLQEWLDELEEMMLVVHMPR.F 2 2.456 0.244 3 3.558 0.227 K.EQLQDMGLVDLFSPEK.S 1 3.792 0.394 2 4.820 0.446 K.GDDITMVLILPKPEK.S 2 2.613 0.198 K.KATEDEGSEQKIPEATNR.R 2 5.310 0.400 3 4.067 0.172 Supplementary Table 1 179 K.KATEDEGSEQKIPEATNRR.V 3 3.830 0.263 K.LPGIVAEGR.D 1 1.820 0.089 K.LQPLDFKENAEQS.R 2 3.186 0.379 K.LQPLDFKENAEQSR.A 2 3.244 0.356 K.NDNDNIFLSPLSISTAFAMTK.L 2 5.273 0.439 3 4.716 0.394 K.SKLPGIVAEGR.D 1 2.040 0.159 2 3.032 0.286 K.SKLPGIVAEGRDDLYVSDAFHK.A 2 2.958 0.264 K.SLAKVEKELTPEVLQEWLDELEEMMLV 3 5.093 0.334 VHMPR.F K.TSDQIHFFFAK.L 1 3.055 0.328 2 4.016 0.301 K.VEKELTPEVLQEWLDELEEMMLVVHM 3 4.737 0.453 PR.F L.VYGAKLQPLDFKENAEQSRAAINK.W 2 2.214 0.106 R.DDLYVSDAFHK.A 1 3.150 0.293 2 3.583 0.262 R.EVPLNTIIFMG.R 2 2.666 0.150 R.EVPLNTIIFMGR.V 1 2.377 0.147 2 3.687 0.245 R.FATTFYQHLADSK.N 2 4.430 0.391 R.FATTFYQHLADSKNDNDNIFLSPLSIST 3 4.402 0.281 AFAMTK.L R.FRIEDGFSLK.E 2 2.920 0.279 R.FRIEDGFSLKEQLQDMGLVDLFSPEK.S 3 6.457 0.419 R.IEDGFSLK.E 1 1.885 0.124 R.RVAEGTQVLELPFK.G 2 4.075 0.290 R.RVAEGTQVLELPFKGDDITMVLILPKPE 3 6.829 0.417 K.S R.SLNPNRVTFK.A 2 2.780 0.217 R.VAEGTQVLELPFK.G 1 2.199 0.327 2 4.084 0.378 R.VAEGTQVLELPFKGDDITMV.L 2 3.347 0.278 R.VAEGTQVLELPFKGDDITMVLILPKPEK. 2 3.622 0.302 S 3 6.094 0.497 R.VWELSK.A 1 2.238 0.103 V.PLNTIIFMGR.V 2 3.483 0.247 O76027 homo sapiens (human). SW:ANX9_HUMAN annexin a9 (annexin 31) (annexin E.QDVQALQRAEGPSR.E 2 2.907 0.240 G xxxi). 10/2001 SW:ANXA_HUMA Q9uj72 homo sapiens (human). IPI:IPI00006609.2 D.AQMLGGALQGFDCDK.D 2 2.693 0.080 O N annexin a10 (annexin 14). 10/2001 (99%) Q16853 homo sapiens (human). SW:AOC3_HUMA membrane copper amine oxidase (ec IPI:IPI00004457.1 M.LSFAGEPLPQNSSMARGFSW.E 2 2.504 0.238 G, P N 1.4.3.6) (vascular adhesion protein- 1) (95%) (vap-1) (hpao). 10/2001 S.ATPRYLYLASNHSNKWGHPR.G 2 2.308 0.185 P21397 homo sapiens (human). SW:AOFA_HUMA amine oxidase [flavin-containing] a (ec IPI:IPI00008483.1 K.ADRLAKLHKEIRKKKI.C 1 2.338 0.175 A, G, O, P N 1.4.3.4) (monoamine oxidase) (mao- (93%) a). 10/2001 V.KLNHPVTHVDQSSDNIIIE.T 2 2.471 0.170 Q92481 homo sapiens (human). transcription factor ap-2 beta (ap2- SW:AP2B_HUMAN M.LWKLVENVKY.E 1 2.159 0.157 A, O beta) (activating enhancer-binding protein 2 beta). 10/2001 Q92754 homo sapiens (human). transcription factor ap-2 gamma (ap2- S.QSADPYSHLGEAYAAAINPLHQPAPTG IPI:IPI00023260.1 SW:AP2C_HUMAN gamma) (activating enhancer- binding 3 3.653 0.144 A SQQQAWPGR.Q (93%) protein 2 gamma) (transcription factor erf-1). 10/2001 P02647 homo sapiens (human). SW:APA1_HUMAN apolipoprotein a-i precursor (apo-ai). -.LSPLGEEMR.D 1 2.283 0.082 A, G, O, P 10/2001 2 2.365 0.194 -.LSPLGEEMRDR.A 2 2.251 0.115 A.KPALEDLR.Q 1 2.296 0.201
Supplementary Table 1 180 2 2.440 0.143 A.KVQPYLDDFQK.K 2 4.160 0.256 A.KVQPYLDDFQKK.W 2 3.132 0.300 A.PYSDELR.Q 1 2.153 0.099 2 2.709 0.176 A.RAHVDALR.T 2 2.852 0.175 A.RHFWQQDEPPQSPWDR.V 2 3.631 0.269 3 4.940 0.286 A.RLEALKENGGAR.L 2 2.707 0.204 A.TEHLSTLSEK.A 1 3.026 0.407 2 2.338 0.230 D.PLRAELQEGAR.Q 2 3.587 0.248 D.SGRDYVSQFEGSALGK.Q 2 4.930 0.472 D.YVSQFEGSALGK.Q 2 3.387 0.374 E.HLSTLSEK.A 2 2.483 0.124 E.HVDALR.M 1 1.874 0.153 E.PPQSPWDR.V 1 1.966 0.171 2 2.910 0.224 F.KVSFLSALEEYTK.K 2 4.089 0.331 F.LSALEEYTK.K 1 2.111 0.254 2 3.274 0.231 G.LLPVLESFK.V 1 2.350 0.231 G.PVTQEFWDNLEK.E 1 2.465 0.168 H.FWQQDEPPQSPWDR.V 2 3.365 0.158 K.AKPALEDLR.Q 1 2.409 0.195 2 2.624 0.194 K.AKPALEDLRQGLLPVLESFKVSFLSALE 3 6.776 0.520 EYTK.K K.AKVQPYLDDFQK.K 2 3.717 0.320 K.AKVQPYLDDFQKK.W 2 3.935 0.443 K.ATEHLSTLSEK.A 1 3.338 0.373 2 3.523 0.349 3 3.696 0.384 K.DLATVYVDVLK.D 1 2.982 0.352 2 3.724 0.261 K.DLATVYVDVLKDSGR.D 1 2.939 0.369 2 4.437 0.462 K.DLATVYVDVLKDSGRDYVSQFEGSAL 2 4.198 0.359 GK.Q 3 4.971 0.387 K.DLEEVKAK.V 1 2.414 0.135 2 2.333 0.105 K.DSGRDYVSQFEGS.A 2 3.157 0.227 K.DSGRDYVSQFEGSALG.K 2 3.416 0.277 K.DSGRDYVSQFEGSALGK.Q 1 3.547 0.403 2 5.562 0.425 3 5.326 0.342 K.ETEGLRQEM.S 1 2.064 0.135 K.ETEGLRQEMSK.D 2 3.274 0.281 K.ETEGLRQEMSKDLEEVK.A 2 4.251 0.229 3 4.821 0.296 K.ETEGLRQEMSKDLEEVKAK.V 2 2.285 0.180 3 5.398 0.260 K.KWQEEMELYR.Q 1 2.802 0.218 2 3.362 0.216 K.LHELQEK.L 1 2.745 0.081 2 2.336 0.107 K.LLDNWDSVTSTF.S 2 4.223 0.245 K.LLDNWDSVTSTFS.K 2 3.853 0.200 K.LLDNWDSVTSTFSK.L 1 2.999 0.337 2 4.592 0.371 K.LREQLGPVTQEF.W 2 3.182 0.357 K.LREQLGPVTQEFWD.N 2 2.811 0.298 K.LREQLGPVTQEFWDNLEK.E 2 5.982 0.510 Supplementary Table 1 181 3 6.275 0.426 K.LREQLGPVTQEFWDNLEKETEGLR.Q 2 2.997 0.116 3 7.063 0.523 K.LREQLGPVTQEFWDNLEKETEGLRQE 3 5.817 0.355 M.S K.LREQLGPVTQEFWDNLEKETEGLRQE 2 3.419 0.374 MSK.D 3 6.686 0.416 K.LREQLGPVTQEFWDNLEKETEGLRQE 3 4.451 0.162 MSKDLEEVK.A K.LREQLGPVTQEFWDNLEKETEGLRQE 3 4.044 0.222 MSKDLEEVKAK.V K.PALEDLR.Q 1 2.001 0.195 K.VEPLRAELQEGA.R 2 2.789 0.153 K.VEPLRAELQEGAR.Q 1 2.336 0.119 2 3.415 0.185 K.VQPYLDDFQK.K 1 2.181 0.088 2 2.605 0.167 K.VQPYLDDFQKK.W 1 2.669 0.150 2 2.646 0.093 K.VQPYLDDFQKKWQEEMELYR.Q 2 3.520 0.349 K.VSFLSALEEY.T 2 2.880 0.162 K.VSFLSALEEYT.K 2 3.942 0.350 K.VSFLSALEEYTK.K 1 3.122 0.423 2 4.515 0.307 K.VSFLSALEEYTKK.L 1 2.690 0.250 2 3.666 0.271 K.WQEEMELY.R 2 2.556 0.145 K.WQEEMELYR.Q 1 2.728 0.257 2 3.303 0.163 L.APYSDELR.Q 1 1.983 0.088 2 2.325 0.188 L.DNWDSVTSTFSK.L 1 2.825 0.293 2 3.900 0.410 L.EALKENGGAR.L 2 2.845 0.201 L.HELQEK.L 1 1.941 0.106 L.LDNWDSVTSTFSK.L 1 2.654 0.355 2 4.893 0.388 L.LPVLESFK.V 1 2.264 0.249 L.PVLESFK.V 1 2.046 0.129 2 2.659 0.192 L.RAELQEGAR.Q 1 1.963 0.239 2 3.597 0.144 L.REQLGPVTQEFWDNLEK.E 2 2.612 0.234 L.RTHLAPYSDELR.Q 2 3.238 0.275 L.SALEEYTK.K 1 1.964 0.142 L.SPLGEEM.R 1 2.067 0.117 L.SPLGEEMR.D 1 2.038 0.154 2 2.689 0.098 M.SKDLEEVK.A 1 2.079 0.148 2 3.132 0.120 M.SKDLEEVKAK.V 2 2.969 0.104 N.WDSVTSTFSK.L 2 2.983 0.234 P.LAARLEALKENGGAR.L 2 3.805 0.289 P.LGEEMRDR.A 2 2.414 0.113 P.LRAELQEGAR.Q 2 2.380 0.123 P.YLDDFQK.K 1 2.607 0.150 2 2.517 0.194 P.YLDDFQKK.W 1 2.208 0.104 2 2.589 0.103 Q.DEPPQSPWDR.V 2 2.574 0.187 Q.DEPPQSPWDRVK.D 2 2.819 0.238 Q.EMSKDLEEVK.A 2 2.319 0.202 Q.GLLPVLESFK.V 2 2.782 0.090 Q.KLHELQEK.L 1 2.794 0.120 Supplementary Table 1 182 2 3.094 0.112 Q.KVEPLRAELQEGAR.Q 2 3.624 0.283 Q.LGPVTQEFWDNLEK.E 2 4.281 0.464 Q.PYLDDFQK.K 1 2.743 0.254 2 3.316 0.265 Q.PYLDDFQKK.W 1 2.842 0.164 2 3.269 0.201 R.AELQEGA.R 1 1.910 0.080 R.AELQEGAR.Q 2 2.656 0.104 R.AHVDALR.T 1 2.035 0.217 R.AHVDALRTHLAPYSDELR.Q 2 3.246 0.328 3 4.696 0.397 R.AHVDALRTHLAPYSDELRQR.L 3 4.993 0.445 R.DYVSQFEGS.A 1 2.494 0.190 R.DYVSQFEGSA.L 1 2.685 0.305 2 2.996 0.313 R.DYVSQFEGSAL.G 2 4.183 0.359 R.DYVSQFEGSALG.K 2 4.104 0.469 R.DYVSQFEGSALGK.Q 1 3.168 0.326 2 4.644 0.446 R.EQLGPVTQEFWD.N 2 3.195 0.310 R.EQLGPVTQEFWDNLEK.E 1 4.056 0.391 2 4.978 0.514 R.EQLGPVTQEFWDNLEKETEGLR.Q 2 3.498 0.419 R.EQLGPVTQEFWDNLEKETEGLRQEMS 3 4.120 0.356 K.D R.EQLGPVTQEFWDNLEKETEGLRQEMS 3 4.039 0.234 KDLEEVK.A R.HFWQQDEPPQSPWDR.V 2 4.282 0.390 R.LAEYHAK.A 2 2.394 0.199 R.LAEYHAKATEHLSTLSEK.A 3 4.004 0.372 R.LEALKENGGAR.L 1 2.387 0.126 2 3.462 0.179 R.QEMSKDLEEVK.A 2 3.657 0.258 R.QEMSKDLEEVKAK.V 2 4.059 0.301 R.QGLLPVLES.F 1 1.854 0.142 R.QGLLPVLESF.K 1 2.268 0.186 2 2.620 0.366 R.QGLLPVLESFK.V 1 3.171 0.214 2 3.619 0.095 R.QGLLPVLESFKVSFLSALEEYTK.K 3 3.695 0.335 R.QKLHELQEK.L 2 2.530 0.080 R.QKVEPLRAELQEGA.R 2 3.156 0.262 R.QKVEPLRAELQEGAR.Q 2 2.967 0.200 R.THLAPYSD.E 1 2.005 0.133 R.THLAPYSDEL.R 1 2.464 0.333 2 2.933 0.302 R.THLAPYSDELR.Q 1 2.841 0.367 2 3.436 0.326 3 3.527 0.282 R.THLAPYSDELRQ.P 2 3.798 0.397 3 4.559 0.358 R.THLAPYSDELRQR.L 2 3.692 0.344 R.VKDLATVYVDVLK.D 1 3.559 0.362 2 4.659 0.350 3 3.758 0.310 R.VKDLATVYVDVLKDSGR.D 1 2.795 0.179 2 5.803 0.559 3 4.752 0.414 R.VKDLATVYVDVLKDSGRDYVSQFEGS 2 4.908 0.383 ALGK.Q 3 5.814 0.392 S.FLSALEEYTK.K 1 2.670 0.275 2 3.670 0.189
Supplementary Table 1 183 S.GRDYVSQFEGSALGK.Q 2 4.169 0.384 S.PLGEEMR.D 1 1.947 0.191 2 2.833 0.202 T.EHLSTLSEK.A 1 2.623 0.290 T.HLAPYSDELR.Q 1 2.601 0.257 2 3.233 0.324 T.VYVDVLK.D 1 2.075 0.246 V.EPLRAELQEGAR.Q 2 2.772 0.223 V.KDLATVYVDVLK.D 1 2.235 0.292 2 4.912 0.392 V.SFLSALEEYTK.K 1 2.701 0.250 2 4.069 0.197 V.SFLSALEEYTKK.L 2 3.830 0.267 V.SQFEGSALGK.Q 1 2.361 0.206 W.QEEMELYR.Q 1 1.967 0.115 2 2.646 0.208 Y.VSQFEGSALGK.Q 1 1.859 0.100 2 2.487 0.127 P02652 homo sapiens (human). SW:APA2_HUMAN apolipoprotein a-ii precursor (apo-aii) C.VESLVSQYFQTVTDYGK.D 2 2.281 0.230 A, G, O, P (apoa-ii). 10/2001 K.AGTELVNFLSYFVELGTQPA.T 2 2.846 0.245 3 4.292 0.340 K.AGTELVNFLSYFVELGTQPAT.Q 2 3.858 0.360 3 4.570 0.273 K.AGTELVNFLSYFVELGTQPATQ.- 2 4.259 0.260 3 5.298 0.425 K.EPCVESLVSQYFQTVTDYGK.D 2 2.576 0.387 K.KAGTELVNFLSYFVELGTQPAT.Q 2 5.085 0.426 K.KAGTELVNFLSYFVELGTQPATQ.- 2 5.389 0.397 K.SKEQLTPLIK.K 1 2.604 0.137 2 3.656 0.272 K.SKEQLTPLIKK.A 1 2.342 0.127 2 3.960 0.294 K.SPELQAEAK.S 1 3.025 0.183 2 3.495 0.183 K.VKSPELQAEA.K 2 2.842 0.125 K.VKSPELQAEAK.S 1 2.613 0.168 2 3.669 0.225 3 3.897 0.152 L.SYFVELGTQPAT.Q 2 3.240 0.272 L.SYFVELGTQPATQ.- 2 4.186 0.384 L.VSQYFQTVTDYGK.D 2 3.901 0.412 S.KEQLTPLIK.K 1 2.448 0.192 2 3.357 0.250 S.KEQLTPLIKK.A 1 1.928 0.094 2 3.111 0.109 S.PELQAEAK.S 1 1.950 0.142 V.KSPELQAEAK.S 1 2.697 0.198 2 3.235 0.137 Y.FVELGTQPAT.Q 1 2.379 0.295 Y.FVELGTQPATQ.- 1 2.331 0.277 2 3.736 0.299 P06727 homo sapiens (human). IPI:IPI00027483.1 SW:APA4_HUMAN apolipoprotein a-iv precursor (apo- A.EVSADQVATVMWDYFSQLSNNAK.E 2 5.099 0.452 A, G, O, P (91%) aiv). 10/2001 3 5.542 0.377 A.KIDQNVEELKGR.L 2 4.264 0.263 A.LVQQMEQLR.T 2 3.183 0.230 E.PYADQLR.T 1 1.849 0.110 F.ATELHER.L 2 2.432 0.210 K.AKIDQNVEELK.G 2 3.771 0.388 K.AKIDQNVEELKGR.L 2 4.130 0.355 3 3.621 0.358
Supplementary Table 1 184 K.ALVQQMEQLR.T 1 2.355 0.158 2 3.697 0.270 K.DSEKLKEEIGKELEELR.A 3 4.873 0.385 K.EAVEHLQK.S 1 2.069 0.096 2 2.876 0.138 K.GRLTPYADEFKVKIDQTV.E 2 2.498 0.108 K.IDQNVEELK.G 1 2.856 0.143 2 3.303 0.188 K.IDQNVEELKGR.L 2 3.721 0.202 K.IDQTVEELR.R 2 3.153 0.221 K.IDQTVEELRR.S 2 2.634 0.161 K.KLVPFATELHER.L 2 3.724 0.305 3 4.020 0.317 K.LGEVNTYAGDLQK.K 1 3.212 0.336 2 4.447 0.332 K.LGPHAGDVEGH.L 2 3.186 0.325 K.LGPHAGDVEGHLSFLEK.D 2 5.640 0.498 3 5.063 0.424 K.LGPHAGDVEGHLSFLEKDLR.D 3 4.828 0.344 K.LKEEIGKELEEL.R 2 4.254 0.196 K.LKEEIGKELEELR.A 1 2.885 0.140 2 5.120 0.221 3 4.881 0.310 K.LNHQLEGLTFQMK.K 1 3.304 0.378 2 4.363 0.333 3 4.035 0.307 K.LVPFATELHER.L 2 2.657 0.297 K.NAEELKAR.I 2 2.480 0.125 K.SELTQQLNALFQDK.L 1 3.455 0.298 2 5.306 0.373 K.SELTQQLNALFQDKLGEVNTYAGDLQK 3 6.337 0.500 .K K.SLAELGGHLDQQVEEFR.R 2 5.762 0.432 3 5.012 0.351 K.SLAELGGHLDQQVEEFRR.R 2 3.545 0.169 3 3.909 0.306 K.TLSLPELEQQQEQHQEQQQEQVQMLA 3 4.110 0.369 PLES.- K.TLSLPELEQQQEQQQEQQQEQVQMLA 2 4.003 0.414 PLES.- 3 5.469 0.352 K.VKIDQTVEELR.R 2 3.474 0.304 K.VKIDQTVEELRR.S 2 3.075 0.209 K.VNSFFSTFK.E 2 2.601 0.145 L.GEVNTYAGDLQK.K 2 3.763 0.385 L.KEEIGKELEELR.A 2 2.662 0.082 L.NHQLEGLTFQMK.K 2 3.341 0.279 L.PHANEVSQK.I 2 2.210 0.114 L.RTQVNTQAEQLR.R 2 4.276 0.295 L.TPYADEFK.V 1 1.895 0.234 2 2.615 0.164 L.VPFATELHER.L 2 2.811 0.344 L.VQQMEQLR.T 2 2.994 0.143 N.EVSQKIGDNLR.E 2 2.632 0.116 P.FATELHER.L 1 1.838 0.154 2 2.874 0.233 P.HAGDVEGHLSFLEK.D 2 4.071 0.490 3 4.395 0.409 P.YADEFK.V 1 2.044 0.104 R.DKVNSFFSTFK.E 2 3.563 0.337 R.ENADSLQASLRPHAD.E 2 2.878 0.348 R.ENADSLQASLRPHADELK.A 2 5.069 0.449 3 3.572 0.334 R.GNLRGNTEGLQK.S 2 3.215 0.281
Supplementary Table 1 185 R.ISASAEELR.Q 1 1.891 0.099 2 3.256 0.216 R.LAKDSEKLKEEIGKELEELR.A 3 5.830 0.341 R.LAPLAEDVR.G 1 1.917 0.091 2 2.727 0.428 R.LEPYADQLR.T 1 2.215 0.095 R.LLPHANEVSQK.I 1 2.598 0.104 2 2.460 0.231 R.LTPYADEFK.V 1 1.865 0.123 R.RQLTPYAQR.M 2 3.353 0.310 R.RSLAPYAQDTQEK.L 2 3.738 0.212 R.RVEPYGENFNK.A 1 2.406 0.219 2 4.047 0.345 R.SLAPYAQDTQEK.L 1 2.801 0.199 2 3.512 0.364 R.SLAPYAQDTQEKLNHQLEGLTFQMK.K 2 2.861 0.346 R.TQVNTQAEQL.R 2 3.108 0.191 R.TQVNTQAEQLR.R 1 2.396 0.284 2 4.078 0.231 R.TQVNTQAEQLRR.Q 2 2.523 0.126 R.VLRENADSLQASLRPHADELK.A 3 3.603 0.238 S.LRPHADELK.A 2 2.256 0.180 T.PYADEFK.V 1 2.062 0.100 T.QVNTQAEQLR.R 2 3.173 0.244 V.PFATELHER.L 2 3.263 0.352 O14727 homo sapiens (human). L.LMKLQNLCTRLDQDESFSQRLPLNIEE IPI:IPI00217462.1 SW:APAF_HUMAN apoptotic protease activating factor 1 2 2.716 0.292 A, G, P AKDR.L (99%) (apaf-1). 10/2001 P04114 homo sapiens (human). apolipoprotein b-100 precursor (apo b- IPI:IPI00022229.1 SW:APB_HUMAN A.TGVLYDYVNK.Y 2 3.216 0.199 A, G, O, P 100) [contains: apolipoprotein b-48 (97%) (apo b-48)]. 10/2001 D.SQHVGHSVLTAK.G 2 2.840 0.294 F.IEDVNKFLDMLIKKLKSFD.Y 2 2.402 0.136 K.AASGTTGTYQEWK.D 1 2.451 0.189 2 3.989 0.454 K.AEPLAFTFSHDYK.G 2 3.671 0.268 K.AGHIAWTSSGK.G 1 3.524 0.335 2 3.124 0.327 K.AHLNIK.S 1 2.028 0.127 K.ALVEQGFTVPEIK.T 2 3.814 0.317 K.ALYWVNGQVPDGVSK.V 2 2.779 0.436 K.ASGSLPYTQTLQDHLNSLK.E 2 3.917 0.458 K.ATFQTPDFIVPLTDLR.I 2 3.804 0.481 K.ATGVLYDYVNK.Y 1 2.839 0.404 2 3.645 0.314 K.AVSMPSFSILGSDVR.V 2 4.173 0.352 K.DFSLWEK.T 1 2.081 0.181 K.DKDQEVLLQTFLDDASPGDK.R 2 3.338 0.354 K.DKDQEVLLQTFLDDASPGDKR.L 2 4.969 0.336 3 6.562 0.387 K.ENFAGEATLQR.I 2 3.501 0.269 K.EQHLFLPFSYK.N 2 2.815 0.345 K.ESQLPTVMDFR.K 2 2.855 0.275 K.EVYGFNPEGK.A 1 2.162 0.108 2 2.849 0.172 K.FPEVDVLTK.Y 1 2.666 0.210 K.FRETLEDTR.D 2 2.892 0.088 K.FSVPAGIVIPSFQALTAR.F 2 2.813 0.310 K.FVTQAEGAK.Q 1 1.986 0.131 K.GFEPTLEALFGK.Q 1 2.861 0.300 2 3.584 0.295 K.GISTSAASPAVGTVGMDMDEDDDFSK. 2 4.367 0.484 W K.GNVATEISTER.D 2 2.221 0.292 Supplementary Table 1 186 K.HINIDQFVR.K 2 3.174 0.152 K.IADFELPTIIVPEQTIEIPSIK.F 2 4.768 0.239 3 4.440 0.248 K.IDDIWNLEVK.E 1 2.759 0.152 2 3.463 0.276 K.IEGNLIFDPNNYLPK.E 2 3.602 0.261 K.IISDYHQQFR.Y 2 3.346 0.370 K.INNQLTLDSNTK.Y 2 3.401 0.199 K.IVQILPWEQNEQVK.N 2 2.817 0.240 K.KIISDYHQQFR.Y 2 3.575 0.318 K.KLTISEQNIQR.A 2 3.763 0.215 K.KMGLAFESTK.S 2 2.571 0.273 K.LALWGEHTGQLYSK.F 2 4.456 0.438 K.LATALSLSNK.F 1 1.836 0.082 K.LDFSSQADLR.N 2 3.472 0.242 K.LEIQSQVDSQHVGHSVLTAK.G 2 3.322 0.394 3 4.454 0.217 K.LHVAGNLK.G 1 2.484 0.203 K.LKQHIEAIDVR.V 2 3.143 0.299 K.LLSGGNTLHLVSTTK.T 2 4.347 0.489 K.LPQQANDYLNSFNWER.Q 2 4.244 0.240 K.LSLESLTSYFSIESSTK.G 2 3.729 0.428 K.LSNDMMGSYAEMK.F 2 3.353 0.299 K.LTISEQNIQR.A 2 3.088 0.286 K.MGLAFESTK.S 1 2.100 0.253 K.MTSNFPVDLSDYPK.S 2 2.400 0.292 K.NFVASHIANILNSEELDIQDLK.K 2 5.806 0.420 3 3.533 0.291 K.NFVASHIANILNSEELDIQDLKK.L 2 5.185 0.343 3 7.492 0.484 K.NHLQLEGLFFTNGEHTSK.A 3 4.427 0.307 K.NIFNFK.V 1 2.211 0.122 K.NIILPVYDK.S 1 2.162 0.203 K.NLTDFAEQYSIQDWAK.R 2 3.561 0.448 K.NSEEFAAAMSR.Y 2 3.647 0.338 K.NSLFFSAQPFEITASTNNEGNLK.V 2 4.464 0.316 K.QGFFPDSVNK.A 2 2.681 0.218 K.QTEATMTFK.Y 1 1.871 0.260 K.QTVNLQLQPYSLVTTLNSDLK.Y 2 4.450 0.451 K.QVFLYPEKDEPTYILNIK.R 2 3.251 0.239 3 3.613 0.236 K.SFDYHQFVDETNDK.I 2 3.317 0.447 K.SGSSTASWIQNVDTK.Y 2 3.289 0.294 K.SHDELPR.T 1 1.891 0.084 2 2.468 0.132 K.SISAALEHK.V 1 1.874 0.101 K.SKPTVSSSMEFK.Y 2 2.975 0.277 K.SLHMYANR.L 1 1.878 0.283 K.SNTVASLHTEK.N 2 3.139 0.333 K.SPAFTDLHLR.Y 2 3.492 0.387 K.SVGFHLPSR.E 2 3.103 0.254 K.SVSDGIAALDLNAVANK.I 1 2.679 0.340 2 5.156 0.402 K.SVSIPSLDPASAK.I 1 2.310 0.228 2 2.662 0.110 K.SVSLPSLDPASAK.I 1 2.138 0.232 2 2.628 0.100 K.TEVIPPLIENR.Q 2 2.906 0.094 K.TILGTMPAFEVSLQALQK.A 2 4.409 0.510 K.TQFNNNEYSQDLDAYNTK.D 2 5.725 0.295 K.VLADKFIIPGLK.L 2 3.171 0.286 K.VLVDHFGYTK.D 1 2.365 0.283 2 3.190 0.322
Supplementary Table 1 187 K.VLVDHFGYTKDDKHEQDMVNGIMLSV 3 4.084 0.245 EK.L K.VNWEEEAASGLLTSLK.D 1 2.918 0.372 2 5.400 0.493 3 4.354 0.338 K.VNWEEEAASGLLTSLKDNVPK.A 2 3.384 0.328 K.VPLLLSEPINIIDALEMR.D 2 4.621 0.379 3 4.483 0.183 K.VSALLTPAEQTGTWK.L 1 2.482 0.203 2 3.822 0.439 K.WNFYYSPQSSPDK.K 2 3.224 0.292 K.WNFYYSPQSSPDKK.L 2 3.919 0.346 K.YDKNQDVHSINLPFFETLQEYFER.N 3 6.379 0.449 K.YENYELTLK.S 1 2.799 0.239 2 2.924 0.243 K.YGMVAQVTQTLK.L 1 2.529 0.211 2 3.560 0.443 K.YHWEHTGLTLR.E 1 2.384 0.374 2 3.269 0.317 K.YKNFATSNK.M 2 2.885 0.277 K.YSQPEDSLIPFFEITVPESQLTVSQFTL 2 3.408 0.345 PK.S 3 3.510 0.331 K.YTYNYEAESSSGVPGTADSR.S 2 5.120 0.383 L.LLSEPINIIDALEMR.D 2 2.949 0.363 L.TISEQNIQR.A 2 2.529 0.117 M.DSSATAYGSTVSK.R 2 3.371 0.366 N.ILNSEELDIQDLK.K 2 2.588 0.197 N.ILNSEELDIQDLKK.L 2 2.715 0.174 P.AFTDLHLR.Y 2 2.907 0.154 R.ATLYALSHAVNNYHK.T 2 4.612 0.313 3 4.475 0.423 R.DLKVEDIPLAR.I 2 2.921 0.081 R.EFQVPTFTIPK.L 2 2.499 0.213 R.EIQIYK.K 1 1.909 1.000 R.EIQIYKK.L 2 2.344 0.133 R.EVGTVLSQVYSK.V 2 3.080 0.312 R.EYSGTIASEANTYLNSK.S 2 3.702 0.417 R.GIISALLVPPETEEAK.Q 2 2.378 0.250 R.HIQNIDIQHLAGK.L 2 3.795 0.383 R.HKFLDSNIK.F 2 2.342 0.139 R.IGQDGISTSATTNLK.C 1 2.540 0.351 2 3.862 0.422 R.IHSGSFQSQVELSNDQEK.A 2 5.546 0.440 3 4.086 0.242 R.ILGEELGFASLHDLQLLGK.L 2 5.365 0.331 R.IPSVQINFK.D 1 2.861 0.203 R.ITENDIQIALDDAK.I 2 4.882 0.355 R.IYSLWEHSTK.N 2 3.074 0.302 R.KGNVATEISTER.D 1 3.176 0.389 2 3.911 0.453 R.KSISAALEHK.V 1 2.478 0.181 2 3.365 0.299 R.KYTYNYEAESSSGVPGTADSR.S 2 5.159 0.391 3 3.567 0.174 R.LNGEIQALELPQK.A 2 2.465 0.116 R.LPYTIITTPPLK.D 1 1.955 0.282 2 3.772 0.203 R.LPYTIITTPPLKDFSLWEK.T 2 3.968 0.251 3 3.725 0.259 R.LTLDIQNK.K 1 2.157 0.115 R.NIQEYLSILTDPDGK.G 1 2.689 0.219 2 4.638 0.303 R.NLQNNAEWVYQGAIR.Q 2 4.822 0.444 Supplementary Table 1 188 R.NNALDFVTK.S 1 2.166 0.148 R.SEILAHWSPAK.L 1 2.210 0.302 2 4.216 0.384 R.SEYQADYESLR.F 2 3.338 0.472 R.TEHGSEMLFFGNAIEGK.S 2 2.355 0.407 R.TFQIPGYTVPVVNVEVSPF.T 2 3.822 0.308 R.TIDQMLNSELQWPVPDIYLR.D 2 3.845 0.367 R.TLADLTLLDSPIK.V 1 3.493 0.397 2 4.086 0.356 R.TLADLTLLDSPIKVPLLLSEPINIIDALEM 3 4.943 0.368 R.D R.TLQGIPQMIGEVIR.K 2 3.216 0.413 R.TPALHFK.S 2 2.570 0.170 R.TSSFALNLPTLPEVK.F 1 3.190 0.283 2 3.968 0.263 R.TSSFALNLPTLPEVKFPEVDVLTK.Y 3 4.103 0.251 R.VAWHYDEEK.I 2 2.418 0.197 R.VIGNMGQTMEQLTPELK.S 2 4.040 0.353 R.VNDESTEGKTSYR.L 2 2.854 0.402 R.VNQNLVYESGSLNFSK.L 2 3.174 0.446 R.VPSYTLILPSLELPVLHVPR.N 2 4.021 0.269 3 6.339 0.479 R.VRESDEETQIK.V 2 3.956 0.251 R.VRESDEETQIKVNWEEEAASGLLTSLK 3 3.668 0.235 DNVPK.A R.VSTAFVYTK.N 1 2.276 0.231 R.YEDGTLSLTSTSDLQSGIIK.N 2 4.984 0.507 T.LREVSSKLRRNLQNNA.E 2 2.424 0.166 T.NGRFREHNAKFSLDGK.A 2 2.670 0.162 V.PEQTIEIPSIK.F 1 3.254 0.262 Y.HWEHTGLTLR.E 2 2.916 0.346 3 3.539 0.338 P02654 homo sapiens (human). SW:APC1_HUMAN apolipoprotein c-i precursor (apo-ci). G.TPDVSSALDK.L 1 2.734 0.270 A, G, O, P 10/2001 2 2.876 0.280 G.TPDVSSALDKLK.E 1 2.875 0.258 2 3.886 0.274 G.TPDVSSALDKLKEFGNTLEDK.A 2 5.057 0.467 3 5.153 0.333 G.TPDVSSALDKLKEFGNTLEDKAR.E 2 3.545 0.309 3 5.746 0.535 I.KQSELSAK.M 1 2.085 0.126 2 2.760 0.127 K.EFGNTLEDKAR.E 2 2.399 0.230 K.LKEFGNTLEDK.A 1 2.732 0.205 2 3.628 0.090 K.MREWFSETFQK.V 2 4.360 0.359 L.KEFGNTLEDK.A 2 3.522 0.287 M.REWFSETFQK.V 2 3.973 0.279 P.DVSSALDK.L 1 1.963 0.084 P.DVSSALDKLK.E 1 2.443 0.124 2 3.071 0.243 P.DVSSALDKLKEFGNTLEDK.A 2 3.461 0.298 3 4.464 0.409 P.DVSSALDKLKEFGNTLEDKAR.E 2 3.531 0.323 3 5.804 0.415 R.EWFSETFQK.V 1 2.805 0.291 2 2.490 0.236 R.IKQSELSAK.M 1 2.397 0.162 2 3.003 0.102 T.PDVSSALDKLK.E 2 2.493 0.175 P02655 homo sapiens (human). SW:APC2_HUMAN apolipoprotein c-ii precursor (apo-cii). A.AQNLYEK.T 2 2.292 0.111 O, P 10/2001 Supplementary Table 1 189 G.TQQPQQDEMPSPTFLTQVK.E 2 4.787 0.418 3 4.449 0.211 K.ESLSSYWESAK.T 1 2.713 0.161 2 3.129 0.400 K.LRDLYSK.S 2 2.897 0.143 K.STAAMSTYTGIFTDQVLSVLK.G 2 4.694 0.486 3 3.506 0.294 K.STAAMSTYTGIFTDQVLSVLKGEE.- 2 5.253 0.402 K.TAAQNLYEK.T 2 3.081 0.175 K.TYLPAVDEK.L 1 1.853 0.186 2 2.523 0.200 Q.DEMPSPTFLTQVK.E 2 3.686 0.390 T.AAQNLYEK.T 2 2.205 0.170 P02656 homo sapiens (human). SW:APC3_HUMAN apolipoprotein c-iii precursor (apo-ciii). A.LSSVQESQVAQQAR.G 2 4.013 0.393 A, G, O, P 10/2001 A.SEAEDASLLSFMQGY.M 2 3.297 0.334 A.SEAEDASLLSFMQGYM.K 2 3.116 0.233 A.SEAEDASLLSFMQGYMK.H 1 3.534 0.370 2 5.862 0.501 3 4.284 0.158 G.WVTDGFSSLK.D 1 2.282 0.326 2 2.916 0.208 K.DALSSVQESQVAQ.Q 2 3.923 0.338 K.DALSSVQESQVAQQA.R 2 5.215 0.339 K.DALSSVQESQVAQQAR.G 1 3.013 0.197 2 5.041 0.342 3 4.721 0.331 K.DKFSEFWDLDPEVRPTSAVAA.- 2 3.611 0.376 K.FSEFWDLDPEVRPTSAVAA.- 2 3.480 0.447 K.TAKDALSSVQESQVAQQAR.G 2 5.756 0.450 3 4.298 0.291 R.GWVTDGFSSLK.D 1 2.801 0.346 2 3.596 0.315 R.GWVTDGFSSLKDYWSTVK.D 2 5.078 0.484 R.VLLVVALLALLASARASEA.E 2 2.574 0.083 P02649 homo sapiens (human). IPI:IPI00021842.1 SW:APE_HUMAN apolipoprotein e precursor (apo-e). A.ATVGSLAGQPLQER.A 2 3.795 0.427 A, G, O, P (92%) 10/2001 A.KLEEQAQQIR.L 2 3.423 0.080 A.KVEQAVETEPEPELR.Q 2 5.091 0.458 A.TVGSLAGQPLQER.A 2 3.650 0.309 K.AYKSELEEQLTPVAEETR.A 2 6.110 0.439 3 3.914 0.197 K.LEEQAQQIR.L 2 3.531 0.195 K.RLAVYQAGAR.E 2 3.131 0.232 K.SELEEQLTPVAEETR.A 2 5.364 0.399 K.SWFEPLVEDMQR.Q 2 3.942 0.267 K.VQAAVGTSAAPVPSDNH.- 1 2.810 0.351 2 5.494 0.500 L.AVYQAGAR.E 2 2.260 0.183 R.AATVGSLAGQPLQER.A 2 4.393 0.443 R.AKLEEQAQQIR.L 1 2.577 0.090 2 4.021 0.151 R.DRLDEVKEQVAEVR.A 2 4.351 0.297 R.GEVQAMLGQSTEELR.V 2 4.573 0.425 R.LAVYQAGAR.E 1 2.097 0.165 2 2.841 0.224 R.LDEVKEQVAEVR.A 2 4.158 0.368 R.LGPLVEQGR.V 1 2.251 0.243 2 2.968 0.173 R.LKSWFEPLVEDMQR.Q 2 3.280 0.287 R.LQAEAFQAR.L 1 2.492 0.156 2 2.320 0.137
Supplementary Table 1 190 R.LSKELQAAQAR.L 2 3.360 0.192 R.QQTEWQSGQR.W 2 2.450 0.242 R.TRDRLDEVKEQVAEVR.A 3 4.171 0.269 R.WELALGR.F 1 2.097 0.102 R.WVQTLSEQVQEELLSSQVTQELR.A 2 4.931 0.196 3 5.950 0.407 S.WFEPLVEDMQR.Q 2 2.652 0.201 Q13790 homo sapiens (human). SW:APF_HUMAN apolipoprotein f precursor (apo-f). K.SYDLDPGAGSLEI.- 2 2.972 0.175 O, P 11/1997 R.SGVQQLIQYYQDQK.D 2 5.007 0.301 3 4.452 0.232 Q15772 homo sapiens (human). aortic SW:APG1_HUMAN preferentially expressed protein 1 T.GSKAPPTFKVSLMDQSVR.E 1 2.282 0.086 G (apeg-1). 10/2001 O14791 homo sapiens (human). apolipoprotein l1 precursor SW:APL1_HUMAN A.NLQSVPHASASRPR.V 2 2.888 0.242 A, O, P (apolipoprotein l-i) (apolipoprotein l) (apol-i) (apo-l) (apol). 10/2001 G.DWAAGTMDPESSIFIEDAIK.Y 2 4.943 0.513 K.EFLGENISNFLSLAGNTYQLTR.G 2 5.386 0.504 K.ILQADQEL.- 1 2.070 0.176 K.KWWTQAQAHDLVIK.S 3 3.918 0.227 K.PLGDWAAGTMDPESSIFIEDAIK.Y 2 5.511 0.467 K.SKLEDNIR.R 2 2.355 0.146 K.VAQELEEK.L 1 2.226 0.193 2 2.568 0.191 K.VAQELEEKLNILNNNYK.I 2 3.253 0.215 Q.NVPSGTDTGDPQSK.P 2 2.708 0.367 R.ALADGVQK.V 1 2.234 0.121 R.ANLQSVPHASASR.P 2 3.112 0.307 R.ANLQSVPHASASRPR.V 2 3.287 0.114 R.VNEPSILEMSR.G 2 3.329 0.316 R.VQQNVPSGTDTGDPQ.S 2 3.168 0.207 R.VQQNVPSGTDTGDPQSK.P 2 4.413 0.424 R.VTEPISAESGEQVER.V 2 4.527 0.471 R.VTEPISAESGEQVERVNEPSILEMS.R 2 3.314 0.443 R.VTEPISAESGEQVERVNEPSILEMSR.G 3 3.740 0.363 Q15848 homo sapiens (human). adiponectin precursor (30 kda SW:APM1_HUMA adipocyte complement-related protein) K.IFYNQQNHYDGSTGK.F 2 4.070 0.434 P N (acrp30) (adipose most abundant gene transcript 1) (gelatin-binding protein). 10/2001 P05090 homo sapiens (human). SW:APOD_HUMA apolipoprotein d precursor (apod). I.KVLNQELR.A 2 2.373 0.148 O, P N 10/2001 K.NILTSNNIDVK.K 1 2.555 0.212 2 3.427 0.141 K.VLNQELR.A 2 2.509 0.145 P.NPPVQENFDVNK.Y 2 3.555 0.414 R.NPNLPPETVDSLK.N 2 2.959 0.125 P02749 homo sapiens (human). beta- 2-glycoprotein i precursor SW:APOH_HUMA (apolipoprotein h) (apo-h) (b2gpi) IPI:IPI00022397.1 A.TVVYQGER.V 2 2.717 0.200 O, P N (beta(2)gpi) (activated protein c- (97%) binding protein) (apc inhibitor). 10/2001 K.ATVVYQGER.V 1 1.979 0.180 2 2.963 0.273 K.EHSSLAFWK.T 1 2.269 0.166 K.FKNGMLHGDK.V 2 2.251 0.197 K.KATVVYQGER.V 2 3.382 0.311 K.KCSYTEDAQCIDGTIEVPK.C 2 2.601 0.090 K.NGMLHGDK.V 2 2.478 0.196 O95445 homo sapiens (human). SW:APOM_HUMA apolipoprotein m (apom) (g3a) K.WIYHLTEGSTDLR.T 2 4.091 0.371 P N (hspc336). 10/2001
Supplementary Table 1 191 R.KWIYHLTEGSTDLR.T 2 3.400 0.143 Q06481 homo sapiens (human). amyloid-like protein 2 precursor SW:APP2_HUMAN (amyloid protein homolog) (apph) M.DQFTASISETPVDVR.V 2 2.289 0.115 A, G (cdei-box binding protein) (cdebp). 10/2001 V.CSQEAMTGPCRAVM.P 1 2.135 0.156 P41181 homo sapiens (human). aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh SW:AQP2_HUMAN R.RGENPGTPALSIGFSVALGHLLG.I 2 2.715 0.082 A water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). 12/ P05089 homo sapiens (human). IPI:IPI00032231.1 SW:ARGI_HUMAN arginase 1 (ec 3.5.3.1) (liver-type L.HGQPVSFLLK.E 1 2.146 0.094 O, P (99%) arginase). 10/2001 P25098 homo sapiens (human). beta- adrenergic receptor kinase 1 (ec SW:ARK1_HUMAN G.VFSEADMRFYAAEII.L 2 2.479 0.200 A, O 2.7.1.126) (beta-ark-1) (g- protein coupled receptor kinase 2). 10/2001 K.QVPPDLFQPYI.E 1 1.835 0.094 P49703 homo sapiens (human). adp- S.AAEVEKRLAVRELAAATLTHVQGCSAV SW:ARLL_HUMAN ribosylation factor-like protein 4l. 3 3.623 0.225 P DGLGLQQGLER.L 10/2001 Q9hbz2 homo sapiens (human). aryl SW:ARN2_HUMAN hydrocarbon receptor nuclear A.NRTPGFAESGQSSGQFQGRPS.E 2 3.098 0.080 P translocator 2 (arnt protein 2). 10/2001 O15142 homo sapiens (human). actin- IPI:IPI00005159.1 SW:ARP2_HUMAN like protein 2 (actin-related protein 2). Y.PGLPSRLERELK.Q 2 2.690 0.186 P (96%) 10/2001 P10523 homo sapiens (human). s- SW:ARRS_HUMA arrestin (retinal s-antigen) (48 kda L.LKKLGSNTYPFLLTFPDYLPCSVMLQ.P 2 2.559 0.201 A, O N protein) (s-ag) (rod photoreceptor arrestin). 10/2001 S.CGVDFEVKAFA.T 1 2.084 0.134 O75110 homo sapiens (human). G.VEGKEGKQASLAADFSITQFKHLGRLL IPI:IPI00220239.1 SW:AT2A_HUMAN potential phospholipid-transporting 3 3.641 0.087 A MVHGRNSYK.R (96%) atpase iia (ec 3.6.1.-). 10/2001 P35670 homo sapiens (human). copper-transporting atpase 2 (ec IPI:IPI00216296.1 SW:AT7B_HUMAN A.HKIKTVMF.D 1 2.240 0.117 A, O, P 3.6.3.4) (copper pump 2) (wilson (96%) disease-associated protein). 10/2001 A.QNGILIKGGKPLEMAHKI.K 2 2.401 0.171 R.KVLAVVGTAEASSE.H 1 2.211 0.092 O14983 h sarcoplasmic/endoplasmic reticulum calcium atpase 1 (ec 3.6.3.8) (calcium pump 1) (serca1) (sr F.NEAKGVYEKVGEATETALTTLVEKMNV IPI:IPI00166650.1 SW:ATA1_HUMAN 2 2.561 0.276 O, P ca(2+)-atpase 1) (calcium-transporting F.N (95%) atpase sarcoplasmic reticulum type, fast twit P.PRSPKEPLISGW.L 2 2.470 0.103 T.GSTYAPEGEVL.K 1 2.208 0.084 P23634 homo sapiens (human). plasma membrane calcium- transporting atpase 4 (ec 3.6.3.8) IPI:IPI00217164.1 SW:ATB4_HUMAN L.VVAVPEGLPLAVTISLAYSVKK.M 2 2.517 0.165 O (pmca4) (plasma membrane calcium (95%) pump isoform 4) (plasma membrane calcium atpase isoform 4). 10/2001 Q92858 homo sapiens (human). SW:ATH1_HUMAN atonal protein homolog 1 (helix-loop- R.SSGGASSSKSPGPVKVREQLCKL.K 2 3.107 0.135 A helix protein hath-1). 12/1998 P51164 homo sapiens (human). potassium-transporting atpase beta SW:ATHB_HUMAN chain (proton pump beta chain) R.IVKFLPSNGSAPRV.D 2 2.905 0.087 G (gastric h+/k+ atpase beta subunit). 10/2001 P14415 homo sapiens (human). sodium/potassium-transporting atpase SW:ATNC_HUMA beta-2 chain (sodium/potassium- V.TCAGKRDEDAENLGNFVMFPA.N 2 2.824 0.116 P N dependent atpase beta-2 subunit). 7/1999 O75882 homo sapiens (human). SW:ATRN_HUMA IPI:IPI00218460.1 attractin precursor (mahogany K.IQVQTEQ.- 1 1.944 0.083 G, O, P N (98%) homolog) (dppt-l). 10/2001 K.LTLTPWVGLR.K 2 2.300 0.137
Supplementary Table 1 192 R.LTGSSGFVTDGPGNYK.Y 2 4.099 0.459 R.NHNALLASLTTQK.K 2 3.623 0.391 R.WSVLPRPDSTMMS.T 1 2.014 0.114 S.CFSDWQGPGCSVPVPANQSFWTREE 2 2.558 0.346 Y.S P46100 homo sapiens (human). transcriptional regulator atrx (x-linked SW:ATRX_HUMAN D.DSCSGSVTYSYSALIVPKEMI.K 2 2.669 0.198 A, O, P helicase ii) (x-linked nuclear protein) (xnp). 10/2001 K.ANLSSDEDGSSDDEPEEGK.K 2 2.860 0.090 O95450 h adam-ts 2 precursor (ec 3.4.24.14) (a disintegrin and metalloproteinase with IPI:IPI00030757.1 SW:ATS2_HUMAN R.TCGTGVKFRTRQCDNPHPANGGRT.C 2 2.648 0.288 G thrombospondin motifs 2) (adamts-2) (94%) (adam-ts2) (procollagen i/ii amino- propeptide processing enzyme) ( O15072 homo sapiens (human). adam-ts 3 precursor (ec 3.4.24.-) (a IPI:IPI00004555.2 SW:ATS3_HUMAN disintegrin and metalloproteinase with K.QDGNWGSWTKFGSC.S 2 2.590 0.136 O (98%) thrombospondin motifs 3) (adamts-3) (adam-ts3) (fragment). 10/2001 Q9p2n4 homo sapiens (human). adam-ts 9 precursor (ec 3.4.24.-) (a IPI:IPI00220898.1 SW:ATS9_HUMAN disintegrin and metalloproteinase with S.FSGETDDDNYLALSSSK.G 2 2.807 0.168 A (96%) thrombospondin motifs 9) (adamts-9) (adam-ts9). 10/2001 Q9h7f0 homo sapiens (human). IPI:IPI00168302.1 SW:ATY3_HUMAN probable cation-transporting atpase 3 G.IQRVENAR.F 1 1.991 0.091 O (99%) (ec 3.6.3.-) (fragment). 10/2001 P27037 homo sapiens (human). IPI:IPI00015691.1 SW:AVR2_HUMAN activin receptor type ii precursor (ec P.EVLEGAINFQRDAFLR.I 2 2.620 0.156 O (91%) 2.7.1.37) (actr-ii) (actriia). 10/2001 Q02246 homo sapiens (human). contactin 2 precursor (axonin-1) IPI:IPI00024966.1 SW:AXO1_HUMAN M.GKANSTGILSVRDATK.I 1 2.103 0.137 G (axonal glycoprotein tag-1) (transient (94%) axonal glycoprotein 1) (tax-1). 10/2001 P08588 homo sapiens (human). beta- SW:B1AR_HUMAN S.LLTRARARGL.V 2 2.626 0.179 A, O 1 adrenergic receptor. 10/2001 P07550 homo sapiens (human). beta- IPI:IPI00012085.1 SW:B2AR_HUMAN K.ARVIILMVWIVSGLTSFLPI.Q 2 2.510 0.175 O 2 adrenergic receptor. 10/2001 (97%) P01884 homo sapiens (human), pan SW:B2MG_HUMA troglodytes (chimpanzee), and gorilla K.VEHSDLSFSK.D 2 3.030 0.314 P N gorilla gorilla (lowland gorilla). beta-2- microglobulin precursor. 10/2001 R.VNHVTLSQPK.I 1 2.402 0.265 2 2.461 0.144 Q99933 homo sapiens (human). bag- family molecular chaperone regulator- SW:BAG1_HUMAN 1 (bcl-2 binding athanogene- 1) (bag- K.KVQAFLAECDT.V 1 2.498 0.155 G 1) (glucocorticoid receptor-associated protein rap46). 10/2001 O60241 homo sapiens (human). SW:BAI2_HUMAN brain-specific angiogenesis inhibitor 2 E.WGSWSLCSRSCGRGSRSR.M 2 2.283 0.177 G, P precursor. 10/2001 R.FFQVVSFMVDAE.N 1 1.853 0.156 P19835 homo sapiens (human). bile- salt-activated lipase precursor (ec 3.1.1.3) (ec 3.1.1.13) (bal) (bile-salt- IPI:IPI00099670.1 SW:BAL_HUMAN S.GAPPVPPTGDSGAPPVTPTGDSETA.P 2 2.734 0.130 A, P stimulated lipase) (bssl) (carboxyl (96%) ester lipase) (sterol esterase) (cholestero P11274 homo sapiens (human). IPI:IPI00154407.1 SW:BCR_HUMAN breakpoint cluster region protein (ec N.LLLSLPEANLLTFLFLLDHLKR.V 2 2.854 0.118 G (91%) 2.7.1.-). 10/2001 Q01742 homo sapiens (human). IPI:IPI00216605.1 SW:BFR2_HUMAN fibroblast growth factor receptor bfr-2 W.IKHVEKNGSKYGPDGLPYLKV.L 2 3.315 0.093 O, P (98%) precursor (ec 2.7.1.112). 10/2001 Q15582 homo sapiens (human). transforming growth factor-beta SW:BGH3_HUMA induced protein ig-h3 precursor (beta IPI:IPI00018219.1 K.DGTPPIDAHTR.N 2 2.355 0.209 O N ig-h3) (kerato-epithelin) (rgd- (91%) containing collagen associated protein) (rgd-cap). 10/2001 R.NHIIKDQLASK.Y 2 3.125 0.206 Q13075 homo sapiens (human). IPI:IPI00152676.1 SW:BIR1_HUMAN E.RNLAEKEDNVK.S 2 2.847 0.115 O baculoviral iap repeat-containing (94%) Supplementary Table 1 193 protein 1 (neuronal apoptosis inhibitory protein). 10/2001 Q9nr09 homo sapiens (human). baculoviral iap repeat-containing SW:BIR6_HUMAN A.GMGGLALIAERLPMLYPEVIQQVSAP.V 2 2.749 0.172 A protein 6 (ubiquitin-conjugating bir- domain enzyme apollon). 10/2001 I.EVVLVKIGLQSTRIGLKLIDILLRNCAASG 3 3.877 0.179 SD.P L.NSPLVR.R 1 1.964 0.111 S.PGISGVDLLVDQPFTLEILTSLV.E 2 2.438 0.102 V.KGEHTQNVPLSVTL.A 1 2.035 0.083 P12643 homo sapiens (human). bone SW:BMP2_HUMA IPI:IPI00025069.1 morphogenetic protein 2 precursor K.QRKRLKSSCK.R 1 1.962 0.126 G N (94%) (bmp-2) (bmp-2a). 10/2001 P22004 homo sapiens (human). bone SW:BMP6_HUMA morphogenetic protein 6 precursor P.PPGAAHPLNRKSLLAPGSGSGGA.S 2 2.411 0.153 A, G N (bmp-6). 10/2001 R.QPPPGAAHPLNRK.S 1 2.040 0.084 Q9h583 homo sapiens (human). IPI:IPI00174993.1 SW:BP28_HUMAN K.AVSFNKSESQEEMLQVFNVE.T 2 2.752 0.130 A, G protein bap28. 10/2001 (96%) L.PFVVINNDDTESAEMKIAIYLSKSG.I 2 3.721 0.129 P51587 homo sapiens (human). IPI:IPI00019408.1 SW:BRC2_HUMAN breast cancer type 2 susceptibility E.EEKEAAKYVEAQQKRLEALF.T 2 2.522 0.179 G, P (97%) protein. 10/2001 K.ESVPVGTGNQLVTFQ.G 2 2.788 0.085 O95696 homo sapiens (human). IPI:IPI00098816.1 SW:BRD1_HUMAN bromodomain-containing protein 1 A.QEMSECNSNKE.N 2 3.216 0.133 A (94%) (br140-like protein). 10/2001 P55201 homo sapiens (human). peregrin (bromodomain and phd SW:BRF1_HUMAN K.YNAKDTIFY.R 1 2.105 0.204 A, P finger-containing protein 1) (br140 protein). 10/2001 T.KLVPLGVNQDLDKEKML.E 2 2.997 0.135 P49335 homo sapiens (human). brain- SW:BRN4_HUMAN specific homeobox/pou domain protein D.EETPTSDELEQFAKQFK.Q 2 2.838 0.131 O 4. 10/2001 P32247 homo sapiens (human). IPI:IPI00027686.1 SW:BRS3_HUMAN bombesin receptor subtype-3 (brs-3). I.GCKVLSFIR.L 2 2.832 0.176 O (95%) 10/2001 P43251 homo sapiens (human). SW:BTD_HUMAN biotinidase precursor (ec 3.5.1.12). E.ALELMNQNLDIY.E 1 2.547 0.089 A, O, P 10/2001 K.SHLIIAQVAK.N 2 2.801 0.268 R.LSSGLVTAALYGR.L 2 2.849 0.429 R.QEALELMNQNLDIYEQQVMTAAQK.D 3 3.700 0.298 R.TSIYPFLDFMPSPQVVR.W 2 3.151 0.362 Q9ny30 homo sapiens (human). btg4 IPI:IPI00168676.1 SW:BTG4_HUMAN F.VTRLVKKHDKLSKQ.Q 1 2.418 0.137 G protein (pc3b). 10/2001 (91%) Q06187 homo sapiens (human). tyrosine-protein kinase btk (ec 2.7.1.112) (bruton's tyrosine kinase) IPI:IPI00029132.1 SW:BTK_HUMAN R.FTNSETAEHIAQ.G 1 2.478 0.098 A (agammaglobulinaemia tyrosine (94%) kinase) (atk) (b cell progenitor kinase) (bpk). 10/2001 O43683 homo sapiens (human). mitotic checkpoint serine/threonine- IPI:IPI00013467.1 SW:BUB1_HUMAN K.ENYGLPQPKNKPTGARTFGER.S 3 3.578 0.184 P protein kinase bub1 (ec 2.7.1.-) (98%) (hbub1) (bub1a). 5/2000 Q02833 homo sapiens (human). SW:C11D_HUMAN protein c11orf13 (hras1-related cluster R.NAEELGHEAFWEQELRREQARERE.G 3 4.284 0.133 P protein 1). 10/2001 O95433 homo sapiens (human). SW:C143_HUMAN protein c14orf3 (protein hspc322). C.EVTEVSK.L 1 2.295 0.161 O 10/2001 P02746 homo sapiens (human). SW:C1QB_HUMA complement c1q subcomponent, b K.LEQGENVFLQATDK.N 2 4.896 0.473 G N chain precursor. 10/2001 K.NSLLGMEGANSIFSGFLLFPDMEA.- 2 2.788 0.158 K.VPGLYYFTYHASSR.G 2 3.703 0.400 N.SIFSGFLLFPDMEA.- 2 3.155 0.133 R.DQTIRFDHVITNMNNNYEPR.S 3 4.764 0.298 R.FDHVITNMNNNYEPR.S 2 5.294 0.379 3 4.052 0.306
Supplementary Table 1 194 S.VPGLYYFTY.H 1 2.021 0.119 P02747 homo sapiens (human). SW:C1QC_HUMA complement c1q subcomponent, c K.FQSVFTVTR.Q 2 2.481 0.183 G, O, P N chain precursor. 10/2001 K.TNQVNSGGVLLR.L 2 3.053 0.159 Q.KFQSVFTVTR.Q 2 2.297 0.183 R.FNAVLTNPQGDYDTSTGK.F 2 4.892 0.316 R.QTHQPPAPNSLIR.F 2 2.907 0.277 P00736 homo sapiens (human). K.LFGEVTSPLFPKPYPNNFETTTVITVPT SW:C1R_HUMAN complement c1r component precursor 3 3.763 0.233 G, O, P GYR.V (ec 3.4.21.41). 10/2001 K.LGNHPIR.R 2 2.268 0.104 K.MGNFPWQVFTNIHGR.G 2 3.276 0.424 3 4.189 0.313 K.PVNPVEQR.Q 2 2.717 0.206 K.PYPNNFETTTVITVPTGYR.V 2 4.410 0.420 K.TLDEFTIIQNLQPQYQFR.D 2 4.507 0.398 3 3.915 0.299 R.VSVHPDYR.Q 1 2.003 0.227 R.WILTAAHTLYPK.E 2 3.532 0.295 R.YTTTMGVNTYK.A 2 2.779 0.367 P09871 homo sapiens (human). IPI:IPI00017696.1 SW:C1S_HUMAN complement c1s component precursor A.EPTMYGEILSPNYPQAYPSEVEK.S 2 4.418 0.369 O, P (97%) (ec 3.4.21.42) (c1 esterase). 10/2001 3 3.949 0.246 K.CQPVDCGIPESIENGKVEDPESTLFGS 3 3.737 0.096 VIR.Y K.EDTPNSVWEPAK.A 2 3.495 0.312 K.GDSGGAFAVQDPNDK.T 2 4.071 0.418 K.GDSGGAFAVQDPNDKTK.F 2 4.353 0.389 K.MLTPEHVFIHPGWK.L 2 3.724 0.412 3 3.590 0.319 K.SNALDIIFQTDLTGQK.K 2 4.473 0.479 K.TMQENSTPRED.- 2 3.177 0.170 K.VEDPESTLFGSVIR.Y 2 4.203 0.451 K.VEKPTADAEAYVFTPN.M 2 4.146 0.388 M.LTPEHVFIHPGWK.L 2 2.433 0.236 R.SSNNPHSPIVEEFQVPY.N 2 3.122 0.169 R.SSNNPHSPIVEEFQVPYNK.L 2 5.016 0.456 3 3.990 0.266 R.TNFDNDIALVR.L 2 3.912 0.359 T.NFDNDIALVR.L 2 3.187 0.268 P11586 h c-1-tetrahydrofolate synthase, cytoplasmic (c1-thf synthase) [includes: IPI:IPI00218342.1 SW:C1TC_HUMAN methylenetetrahydrofolate A.SSKKGEPVSAEDLGVSGAL.T 1 2.390 0.137 G (96%) dehydrogenase (ec 1.5.1.5); methenyltetrahydrofolate cyclohydrolase (ec 3.5.4.9); P24903 homo sapiens (human). IPI:IPI00103355.1 SW:C2F1_HUMAN cytochrome p450 2f1 (ec 1.14.14.1) F.DPTFVLSR.S 1 2.594 0.087 G, O (93%) (cypiif1). 12/1998 S.SPWGELYDILDPR.F 2 2.480 0.158 P04003 homo sapiens (human). c4b- binding protein alpha chain precursor SW:C4BP_HUMAN I.NLPDIPHASWETYPRPTKEDVY.V 2 2.432 0.154 A, G, O, P (c4bp) (proline-rich protein) (prp). 10/2001 K.EDVYVVGTVLR.Y 1 2.088 0.276 2 3.300 0.417 K.LNNGEITQHR.K 2 3.238 0.278 K.LNNGEITQHRK.S 2 2.757 0.115 K.LSLEIEQLELQR.D 2 3.863 0.259 K.MALEVYK.L 1 2.247 0.185 L.DTIVFK.- 1 2.081 0.093 L.NNGEITQHR.K 2 2.640 0.172 R.KPDVSHGEMVSGFGPIYNYK.D 2 5.883 0.557 3 5.803 0.460 SW:CA11_HUMAN P02452 homo sapiens (human). A.PGAKGARGSAGPPGATGFPGAAGRV 2 2.487 0.116 A, G IPI:IPI00182059.1 Supplementary Table 1 195 collagen alpha 1(i) chain precursor. GPP.G (95%) 10/2001 V.VGLPGQRGERGFPGLPGPSGEPGKQ 2 3.009 0.110 GP.S P02458 homo sapiens (human). IPI:IPI00180300.1 SW:CA12_HUMAN collagen alpha 1(ii) chain precursor P.NPANVPK.K 1 2.071 0.252 G, O, P (95%) [contains: chondrocalcin]. 10/2001 P27658 homo sapiens (human). IPI:IPI00219000.1 SW:CA18_HUMAN collagen alpha 1(viii) chain precursor P.GPQGYPGVGKPGMPGMPGK.P 2 2.211 0.184 A, O (98%) (endothelial collagen). 10/2001 V.GKPGVTGFPGPQGPLGKPGAPGE.P 2 2.439 0.137 P12107 homo sapiens (human). IPI:IPI00177552.1 SW:CA1B_HUMAN collagen alpha 1(xi) chain precursor. E.QGLPGAAGK.E 1 1.875 0.248 A (99%) 10/2001 Q99715 homo sapiens (human). IPI:IPI00005296.2 SW:CA1C_HUMAN collagen alpha 1(xii) chain precursor. D.YNELANIASKPSERHV.F 1 2.024 0.181 P (96%) 10/2001 Q07092 homo sapiens (human). SW:CA1F_HUMAN collagen alpha 1(xvi) chain precursor. G.LPGPPGIGLPGTPGDPGGPPGPK.G 2 2.304 0.159 G 10/2001 P.GFGLPGLPGRAGVPGLK.G 2 2.517 0.092 P39060 homo sapiens (human). SW:CA1H_HUMAN collagen alpha 1(xviii) chain precursor G.EPGGGGFFGSSLPGPPGPPGPR.G 2 2.298 0.249 G, O [contains: endostatin]. 10/2001 G.VNSSDVPGPAGLPGVPGR.E 1 2.147 0.111 K.GEVGADGIPGFPGLPGREGIAGPQGP. 3 3.552 0.155 K P08572 homo sapiens (human). SW:CA24_HUMAN collagen alpha 2(iv) chain precursor. W.IGYSFLMHTAAGDEGGGQ.S 1 2.510 0.127 G 10/2001 P25067 homo sapiens (human). collagen alpha 2(viii) chain IPI:IPI00012419.1 SW:CA28_HUMAN G.LGKPGLDGLPGA.P 1 2.081 0.119 A, O (endothelial collagen) (fragment). (92%) 10/2001 G.VPGSPGITGPPGLPGPPGAPGAFDET 3 3.887 0.095 GIAGLHLPNGGVEGA.V P25940 homo sapiens (human). SW:CA35_HUMAN collagen alpha 3(v) chain (fragments). V.GPLGERGPPGPPGPPGEQGLPGLE.G 2 2.791 0.170 G 10/2001 P12111 homo sapiens (human). IPI:IPI00220701.1 SW:CA36_HUMAN collagen alpha 3(vi) chain precursor. D.IVFLVDGSSALGLANF.N 1 2.464 0.089 A, G (93%) 10/2001 V.VKMLREVQVFEITENSAKLHWE.R 2 2.740 0.098 P53420 homo sapiens (human). SW:CA44_HUMAN collagen alpha 4(iv) chain precursor. P.GSSGPPGPAGATGR.A 2 2.580 0.155 A 10/2001 Q9y6j0 homo sapiens (human). I.EGTSTEVPCLPEGADPSPPVVNELYYL. IPI:IPI00217180.1 SW:CABI_HUMAN calcineurin-binding protein cabin 1 2 2.689 0.163 A, G, P L (94%) (calcineurin inhibitor) (cain). 10/2001 L.SSPPTAASSKAPSSGSAQPPE.G 2 2.843 0.257 R.LPILSSQAGATGKDLQGATEERG.K 2 2.627 0.096 P12830 homo sapiens (human). epithelial-cadherin precursor (e- SW:CAD1_HUMAN A.ILGILGGILALLILILLLLLFLRRRAVVK.E 3 4.010 0.101 A, G cadherin) (uvomorulin) (cadherin-1) (cam 120/80). 10/2001 V.GQEITSYTAQEPDTFMEQK.I 2 2.707 0.121 P33151 homo sapiens (human). vascular endothelial-cadherin SW:CAD5_HUMAN precursor (ve-cadherin) (cadherin-5) K.ELDSTGTPTGK.E 2 2.485 0.333 O (7b4 antigen) (cd144 antigen). 10/2001 K.KGDIYNEK.E 2 2.468 0.202 Q9ulb4 homo sapiens (human). IPI:IPI00008022.1 SW:CAD9_HUMAN E.NAKPGQLIQTVSVMDKDDPPRGHK.F 2 2.214 0.158 A, O cadherin-9 precursor. 10/2001 (97%) S.RNKMSTYLLPILIF.D 3 3.845 0.131 P55289 homo sapiens (human). brain- SW:CADC_HUMA cadherin precursor (br-cadherin) IPI:IPI00024041.1 I.VILLAIVVLYV.A 1 2.375 0.103 P N (cadherin-12) (n-cadherin 2) (94%) (cadherin, neural type, 2). 10/2001 P55290 homo sapiens (human). cadherin-13 precursor (truncated- SW:CADD_HUMA IPI:IPI00180025.1 cadherin) (t-cadherin) (t-cad) (heart- I.VTVVSPALLDR.E 1 1.868 0.168 G N (99%) cadherin) (h-cadherin) (p105). 10/2001 SW:CADG_HUMA O75309 homo sapiens (human). L.QGAQPGDTYTVLV.E 2 2.649 0.087 G IPI:IPI00025240.1 Supplementary Table 1 196 N cadherin-16 precursor (kidney-specific (95%) cadherin) (ksp-cadherin). 10/2001 S.HVVYQLLSPEPEDGV.E 2 2.508 0.166 O43570 homo sapiens (human). carbonic anhydrase xii precursor (ec SW:CAHC_HUMA IPI:IPI00012895.1 4.2.1.1) (carbonate dehydratase xii) E.MINNFRQVQK.F 1 2.425 0.090 P N (92%) (ca-xii) (tumor antigen hom-rcc-3.1.3). 10/2001 SW:CALG_HUMA O14967 homo sapiens (human). T.GSGDGPIKSVR.K 1 2.059 0.126 G, O N calmegin precursor. 10/2001 Q9y6q1 homo sapiens (human). calpain 6 (calpamodulin) (calpm) SW:CAN6_HUMAN L.KSLYLRKKGGPTAK.V 1 1.831 0.088 O, P (calpain-like protease x-linked). 10/2001 V.DMQKGRYTELVEE.K 2 3.954 0.104 P08185 homo sapiens (human). IPI:IPI00027482.1 SW:CBG_HUMAN corticosteroid-binding globulin K.GTWTQPFDLASTR.E 2 3.318 0.333 O, P (97%) precursor (cbg) (transcortin). 10/2001 K.HLVALSPK.K 1 1.875 0.170 K.MNTVIAALSR.D 2 3.447 0.228 R.ITQDAQLK.S 1 1.978 0.158 R.SETEIHQGFQHLHQLFAK.S 2 4.689 0.525 3 4.568 0.351 R.WSAGLTSSQVDLYIPK.V 2 4.913 0.357 Q13191 homo sapiens (human). IPI:IPI00216180.1 SW:CBLB_HUMAN signal transduction protein cbl-b (sh3- V.PLPPARRLPGENVKTNR.T 1 2.145 0.104 A (91%) binding protein cbl-b). 10/2001 Q92793 homo sapiens (human). creb- SW:CBP_HUMAN L.IGYLEYVKKLGYVTG.H 2 2.776 0.166 A binding protein. 10/2001 P22792 homo sapiens (human). carboxypeptidase n 83 kda chain IPI:IPI00027504.1 SW:CBP8_HUMAN K.AGGSWDLAVQER.A 2 3.370 0.365 O, P (carboxypeptidase n regulatory (91%) subunit) (fragment). 10/2001 K.LSNNALSGLPQGVFGK.L 2 3.910 0.383 K.TLNLAQNLLAQLPEELFHPLTSLQTLK.L 3 4.458 0.327 R.LFQPLTHLK.T 2 2.555 0.121 P16870 homo sapiens (human). carboxypeptidase h precursor (ec SW:CBPH_HUMA 3.4.17.10) (cph) (carboxypeptidase e) A.QYLCNEYQK.G 2 2.583 0.176 G, O N (cpe) (enkephalin convertase) (prohormone processing carboxypeptidase). 10/2001 S.CEKFPPEETLKT.Y 2 3.183 0.134 P14384 homo sapiens (human). SW:CBPM_HUMA IPI:IPI00026270.1 carboxypeptidase m precursor (ec P.HITKVIIPEKSQNFSAL.K 2 2.555 0.101 A, G N (97%) 3.4.17.12). 10/2001 R.ENYNQYDLN.R 1 2.300 0.132 P15169 homo sapiens (human). carboxypeptidase n catalytic chain SW:CBPN_HUMA precursor (ec 3.4.17.3) (arginine IPI:IPI00010295.1 D.NFPDLNTYIYYNEK.Y 2 3.045 0.344 O N carboxypeptidase) (kininase 1) (serum (96%) carboxypeptidase n) (scpn) (anaphylatoxin inactivato K.YVGNMHGNEALGR.E 2 3.332 0.398 R.HLYVLEFSDHPGIHEPLEPEVK.Y 2 3.928 0.435 3 5.768 0.429 R.IHILPSMNPDGYEVAAAQGPNKPGYLV 3 3.770 0.359 GR.N R.IVQLIQDTR.I 2 3.446 0.126 R.NNANGVDLNR.N 2 2.895 0.289 R.RTASTPTPDDK.L 2 2.707 0.178 R.TASTPTPDDKLFQK.L 2 2.754 0.275 P50851 homo sapiens (human). cdc4- SW:CC4H_HUMA IPI:IPI00002255.2 like protein (beige-like protein) I.CSTLLAFIMELLKNSIAM.Q 1 2.106 0.179 O N (93%) (fragment). 10/2001 L.RENSKATDEDILAKGKQSIR.S 2 2.677 0.233 T.ERLEHALEKAAPLLREIFVDFA.P 2 2.503 0.221 O00555 homo sapiens (human). voltage-dependent p/q-type calcium SW:CCAA_HUMA channel alpha-1a subunit (calcium I.ISLLFLLFLFI.V 1 2.092 0.084 P N channel, l type, alpha-1 polypeptide isoform 4) (brain calcium channel i)
Supplementary Table 1 197 (bi). 10/2001 L.FMFIFAVVAVQLFKGKFFH.C 2 2.404 0.136 Q13936 homo sapiens (human). voltage-dependent l-type calcium SW:CCAC_HUMA channel alpha-1c subunit (calcium L.GQFAQDPKFIEVTTQ.E 2 3.616 0.108 O, P N channel, l type, alpha-1 polypeptide, isoform 1, cardiac muscle). 10/2001 O43497 homo sapiens (human). SW:CCAG_HUMA voltage-dependent t-type calcium F.FIVIAGMLEYSLDLQNVSF.S 2 2.531 0.102 A, G, O N channel alpha-1g subunit (nbr13) (cav3.1c). 10/2001 F.ICSQPRENGMRS.C 1 2.128 0.085 I.ARVLKLLKMAVGMRALLDTV.M 2 2.429 0.229 I.AVSCLDSGSQPHLGTDPSNLGGQPLG 3 3.783 0.207 GPGSRPKKKLSPP.S R.GWGLPKAQSGSVLSVHS.Q 2 2.934 0.142 O95180 homo sapiens (human). SW:CCAH_HUMA voltage-dependent t-type calcium L.ATGLGTMNYPTILP.S 2 2.773 0.205 O, P N channel alpha-1h subunit. 10/2001 S.LRLYARWQSRWRKKVDPSA.V 2 2.528 0.116 P30991 homo sapiens c-x-c chemokine receptor type 4 (cxc-r4) SW:CCR4_HUMA (cxcr-4) (stromal cell- derived factor 1 IPI:IPI00216445.1 E.ENANFNK.I 1 1.857 0.114 G, O N receptor) (sdf-1 receptor) (fusin) (99%) (leukocyte-derived seven transmembrane domain recep I.MVGLILPGIVILSCY.C 2 2.502 0.198 P08571 homo sapiens (human). monocyte differentiation antigen cd14 SW:CD14_HUMAN precursor (lps receptor) (lps-r) K.ITGTMPPLPLEATGLALSSLR.L 2 3.341 0.442 O, P (myeloid cell-specific leucine-rich glycoprotein). 10/2001 R.AFPALTSLDLSDNPGLGER.G 2 3.319 0.369 R.LKELTLEDLK.I 2 3.200 0.215 R.LTVGAAQVPAQLLVGALR.V 2 3.572 0.420 R.RLTVGAAQVPAQLLVGALR.V 3 3.547 0.232 P09693 homo sapiens (human). t-cell SW:CD3G_HUMA surface glycoprotein cd3 gamma chain IPI:IPI00016020.1 A.EIVSIFVLAVGVYF.I 2 3.107 0.101 G, P N precursor (t-cell receptor t3 gamma (93%) chain). 10/2001 G.KGLAVLILAI.I 1 2.076 0.113 P16070 h cd44 antigen precursor (phagocytic glycoprotein i) (pgp-1) (hutch-i) (extracellular matrix receptor- IPI:IPI00166967.1 SW:CD44_HUMAN A.DLCKAFN.S 1 2.048 0.087 O iii) (ecmr-iii) (gp90 lymphocyte (93%) homing/adhesion receptor) (hermes antigen) (hy P48960 homo sapiens (human). IPI:IPI00185988.1 SW:CD97_HUMAN leucocyte antigen cd97 precursor. E.LLCAFWKSDSDRGGHW.A 1 2.098 0.188 G (97%) 10/2001 Q9y5h9 homo sapiens (human). P.SLWATTSVSIEVADVNDNAPAFAQPEY IPI:IPI00027841.1 SW:CDA2_HUMAN protocadherin alpha 2 precursor 3 4.407 0.256 A, G, O, P TVFV.K (97%) (pcdh-alpha2). 10/2001 Q9un74 homo sapiens (human). IPI:IPI00219141.1 SW:CDA4_HUMAN protocadherin alpha 4 precursor I.IVKGYIDFEESKSYEI.I 1 2.992 0.144 G (95%) (pcdh-alpha4). 10/2001 Q9y5h7 homo sapiens (human). IPI:IPI00221113.1 SW:CDA5_HUMAN protocadherin alpha 5 precursor K.PELTGTVQLLINVLDAN.D 2 2.686 0.113 G (95%) (pcdh-alpha5). 10/2001 Q9y5f3 homo sapiens (human). L.LVDGFSEPYLQFQDPTKHSRKVNPSTK IPI:IPI00001452.1 SW:CDB1_HUMAN protocadherin beta 1 precursor (pcdh- 3 4.275 0.158 G YL.V (93%) beta1). 10/2001 Q9y5f2 homo sapiens (human). SW:CDBB_HUMA IPI:IPI00001451.1 protocadherin beta 11 precursor L.DREELCGSIEPCVLHLQVLMQN.P 2 2.476 0.127 G, O N (95%) (pcdh-beta11). 10/2001 S.ATDRDSGTNAQVNY.S 2 2.518 0.142 P50750 homo sapiens (human). cell division protein kinase 9 (ec 2.7.1.-) IPI:IPI00001474.2 SW:CDK9_HUMAN F.CDEVSK.Y 1 2.091 0.157 A, O (serine/threonine-protein kinase (99%) pitalre) (c-2k). 10/2001 Q15131 homo sapiens (human). cell SW:CDKA_HUMA division protein kinase 10 (ec 2.7.1.-) IPI:IPI00166810.1 L.RLRHPNIVELKE.V 2 2.919 0.150 O, P N (serine/threonine-protein kinase (96%) pisslre). 10/2001
Supplementary Table 1 198 O95674 h phosphatidate cytidylyltransferase 2 (ec 2.7.7.41) (cdp-diglyceride synthetase 2) (cdp- SW:CDS2_HUMAN L.VQREEPLRILSKYHR.F 2 3.449 0.212 O diglyceride pyrophosphorylase 2) (cdp- diacylglycerol synthase 2) (cds 2) (ctp:phosphatidate P40198 homo sapiens (human). carcinoembryonic antigen-related cell L.VCFLLLAKTGRTSIQRDLKEQQPQALAP IPI:IPI00181080.1 SW:CEA3_HUMAN adhesion molecule 3 precursor 3 3.602 0.152 P GR.G (99%) (carcinoembryonic antigen cgm1) (cd66d antigen). 10/2001 P49454 homo sapiens (human). cenp- SW:CENF_HUMA f kinetochore protein (centromere IPI:IPI00006010.1 A.ALVEKGEFALR.L 2 2.540 0.219 A N protein f) (mitosin) (ah antigen). (98%) 10/2001 P23435 homo sapiens (human). SW:CERB_HUMA cerebellin precursor (precerebellin). R.SGSAKVAFSAIRST.N 1 1.802 0.112 A N 10/2001 P00450 homo sapiens (human). SW:CERU_HUMA IPI:IPI00175119.1 ceruloplasmin precursor (ec 1.16.3.1) A.KEKHYYIGIIETTWDYASDHGEK.K 3 5.604 0.488 A, G, O, P N (99%) (ferroxidase). 5/2000 A.LYLQYTDETFR.T 2 3.378 0.326 A.YPLSIEPIGVR.F 1 2.193 0.272 2 3.383 0.306 F.PGTYQTLEMFPR.T 1 2.553 0.313 F.TTAPDQVDKEDEDFQESNK.M 2 4.249 0.333 G.AYPLSIEPIGVR.F 2 2.921 0.102 H.AAFFHGQALTNK.N 2 3.559 0.301 H.GVQTESSTVTPTLPGETLTYVWK.I 2 4.784 0.382 H.SHGITYYK.E 1 2.408 0.285 K.AEEEHLGILGPQLHAD.V 2 3.128 0.293 K.AEEEHLGILGPQLHADVGDK.V 2 5.315 0.356 3 5.792 0.332 K.AEEEHLGILGPQLHADVGDKVK.I 2 3.662 0.357 3 4.830 0.449 K.AETGDKVYVHLK.N 2 3.838 0.400 K.ALYLQYTDETF.R 2 2.996 0.415 K.ALYLQYTDETFR.T 1 3.003 0.364 2 4.213 0.377 K.DDEEFIESNK.M 1 3.174 0.157 2 4.313 0.291 K.DIFTGLIGPMK.I 1 2.940 0.341 2 3.847 0.327 K.DSLDKEKEK.H 2 2.561 0.087 K.DVDKEFYLFPTVFDENESLLLEDNIR.M 2 3.175 0.302 3 5.049 0.489 K.EFYLFPTVFDENESLLLEDNIR.M 2 3.693 0.206 K.ERGPEEEHLGILGPVIWAEVGDTIR.V 3 6.960 0.493 K.EVGPTNADPVCLAK.M 2 3.265 0.458 K.GAYPLSIEPIGV.R 2 2.408 0.221 K.GAYPLSIEPIGVR.F 1 2.203 0.311 2 3.670 0.374 K.GEFYIGSK.Y 1 1.892 0.089 K.HYYIGIIETTWDYASDHGEK.K 2 5.864 0.535 3 6.969 0.490 K.HYYIGIIETTWDYASDHGEKK.L 3 5.144 0.441 K.KALYLQYTDETFR.T 2 4.970 0.448 K.KLISVDTEHSN.I 2 3.582 0.184 K.KLISVDTEHSNIYLQNGPDR.I 2 6.084 0.447 3 5.585 0.421 K.LISVDTEHSNIYLQNGPDR.I 2 5.432 0.472 3 4.408 0.216 K.MYYSAVDPTK.D 1 3.252 0.306 2 3.434 0.262 K.MYYSAVDPTKDIFTGLIGPM.K 2 3.669 0.171 K.MYYSAVDPTKDIFTGLIGPMK.I 2 5.344 0.384 3 5.271 0.315 Supplementary Table 1 199 K.NLASRPYTF.H 2 2.496 0.246 K.NLASRPYTFH.S 2 3.180 0.296 K.NLASRPYTFHSH.G 2 3.183 0.338 K.NLASRPYTFHSHGITYYK.E 2 3.040 0.300 3 4.793 0.293 K.NMATRPYSIHAHGVQTESSTVTPTLPG 3 5.014 0.290 ETLTYVWK.I K.NNEGTYYSPNYNPQS.R 2 3.367 0.127 K.NNEGTYYSPNYNPQSR.S 1 2.587 0.153 2 4.503 0.404 K.TYSDHPEK.V 2 2.655 0.204 K.TYSDHPEKVNKDDEEFIESNK.M 3 5.346 0.422 K.VDKDNEDFQESN.R 2 3.203 0.240 K.VDKDNEDFQESNR.M 2 4.365 0.359 K.VNKDDEEFIESN.K 2 3.075 0.106 K.VNKDDEEFIESNK.M 1 3.918 0.314 2 4.640 0.371 K.VNKDDEEFIESNKMHAINGR.M 3 4.588 0.336 K.VYPGEQYTY.M 2 3.140 0.292 K.WYLFGMGNEVDVHAAFFHGQALTNK. 3 5.501 0.448 N L.YLQYTDETFR.T 2 2.827 0.257 M.ETTYTVLQNEDTK.S 2 3.712 0.363 M.GMGNEIDLHTVHFHGHSFQYK.- 2 2.776 0.230 N.NEGTYYSPNYNPQSR.S 2 2.625 0.253 Q.SEDSTFYLGER.T 2 3.671 0.410 R.ADDKVYPGEQYTY.M 2 3.475 0.411 R.DTANLFPQTSL.T 2 3.036 0.138 R.EYTDASFTNR.K 1 1.965 0.291 2 3.258 0.317 R.EYTDASFTNRK.E 2 2.592 0.266 R.FNKNNEGTYYSPNYNPQS.R 2 3.238 0.219 R.FNKNNEGTYYSPNYNPQSR.S 2 5.279 0.347 3 4.886 0.298 R.GPEEEHLGILGPVIWAEVGDTI.R 2 5.146 0.485 R.GPEEEHLGILGPVIWAEVGDTIR.V 2 5.887 0.495 3 6.006 0.369 R.GVYSSDVFDIFPGTYQTLEMFPR.T 2 5.215 0.373 3 3.799 0.339 R.IYHSHIDAPK.D 1 2.760 0.278 2 3.465 0.262 R.KAEEEHLGILGPQLHAD.V 2 4.845 0.450 3 4.715 0.145 R.KAEEEHLGILGPQLHADVGDK.V 2 5.934 0.487 3 7.705 0.325 R.KAEEEHLGILGPQLHADVGDKV.K 3 5.321 0.308 R.KAEEEHLGILGPQLHADVGDKVK.I 2 5.538 0.370 3 7.022 0.401 R.KERGPEEEHLGILGPVIWAEVGDTIR.V 3 4.698 0.372 R.MFTTAPDQVDK.E 2 2.347 0.221 R.MFTTAPDQVDKEDEDFQESN.K 2 5.192 0.448 R.MFTTAPDQVDKEDEDFQESNK.M 2 4.344 0.353 3 4.062 0.349 R.PYSIHAHGVQTESSTVTPTLPGETLTYV 3 4.980 0.303 WK.I R.PYTFHSHGITYYK.E 2 4.167 0.455 R.QKDVDKEFYLFPTVFDENESLLLEDNIR 3 5.173 0.412 .M R.QSEDSTFYLGER.T 2 3.396 0.393 R.RKLEFALLFLVFDENESWYLDDNIK.T 3 5.782 0.362 R.RQSEDSTFYLGER.T 2 4.286 0.405 3 3.563 0.174 R.SVPPSASHVAPTETFTYEWTVPK.E 2 2.877 0.175 R.TTIEKPVWLGF.L 2 3.063 0.337 R.TTIEKPVWLGFLGPIIK.A 1 3.862 0.372 Supplementary Table 1 200 2 4.464 0.356 3 4.077 0.358 S.TVTPTLPGETLTYVWK.I 2 2.924 0.317 V.PPSASHVAPTETFTYEWTVPK.E 2 3.271 0.323 3 4.702 0.365 Y.LFPTVFDENESLLLEDNIR.M 2 3.293 0.329 Y.LQYTDETFR.T 2 2.763 0.245 Y.REYTDASFTNR.K 2 2.889 0.258 Y.SAVDPTKDIFTGLIGPMK.I 2 2.956 0.382 Y.SIHAHGVQTESSTVTPTLPGETLTYVW 2 2.520 0.170 K.I 3 5.386 0.265 Y.YSAVDPTKDIFTGLIGPMK.I 2 4.119 0.541 P00751 homo sapiens (human). complement factor b precursor (ec IPI:IPI00177988.1 SW:CFAB_HUMAN 3.4.21.47) (c3/c5 convertase) A.GIPEFYDYDVALIK.L 2 2.636 0.340 A, G, O, P (98%) (properdin factor b) (glycine-rich beta glycoprotein) (gbg) (pbf2). 10/2001 G.LVTYATYPK.I 2 2.849 0.237 I.PEFYDYDVALIK.L 1 2.249 0.257 K.ALFVSEEEK.K 1 2.152 0.266 2 2.306 0.202 K.ALFVSEEEKK.L 1 2.486 0.225 2 3.176 0.186 K.DISEVVTPR.F 1 2.508 0.230 2 3.305 0.345 K.DNEQHVFK.V 1 2.331 0.135 K.EAGIPEFYDYDVA.L 2 2.514 0.230 K.EAGIPEFYDYDVAL.I 2 2.656 0.230 K.EAGIPEFYDYDVALIK.L 1 2.732 0.139 2 3.297 0.405 K.EELLPAQDIK.A 1 2.414 0.200 2 2.558 0.127 K.EKLQDEDLGF.L 2 3.735 0.350 K.EKLQDEDLGFL.- 2 4.202 0.351 K.GTDYHKQPWQAK.I 2 3.288 0.174 K.KDNEQHVFK.V 1 2.336 0.201 2 3.118 0.167 K.KEAGIPEFYDYDVALIK.L 2 4.307 0.395 3 3.724 0.184 K.NPREDYLDVYVFGVGPLVNQVNINALA 3 5.943 0.385 SK.K K.QLNEINYEDHK.L 2 3.156 0.302 K.VASYGVKPR.Y 1 1.875 0.107 2 2.732 0.190 K.VKDISEVVTPR.F 1 2.301 0.081 2 3.925 0.256 K.VSEADSSNADWVTK.Q 1 3.214 0.416 2 5.295 0.507 K.VSVGGEKR.D 2 2.251 0.169 K.YGQTIRPICLPCTEGTTR.A 2 2.833 0.170 Q.LNEINYEDHK.L 2 2.695 0.145 R.DAQYAPGYDK.V 1 2.479 0.203 2 3.252 0.336 R.DAQYAPGYDKVK.D 2 2.913 0.284 R.DAQYAPGYDKVKDISEVVTPR.F 3 3.688 0.244 R.DFHINLFQVLPWLK.E 1 3.711 0.321 2 4.621 0.364 3 4.173 0.138 R.DLEIEVVLFHPNYNINGK.K 2 3.063 0.100 R.DLLYIGK.D 1 2.245 0.122 R.EDYLDVYVFGVGPLVNQVNINALASK.K 2 3.090 0.205 R.FLCTGGVSPYADPNTCRGDSGGPLIVH 3 3.807 0.137 KR.S R.GDSGGPLIVHK.R 1 2.180 0.233
Supplementary Table 1 201 2 3.556 0.357 R.GDSGGPLIVHKR.S 2 3.418 0.382 R.HVIILMTDGLHNMGGDPITVIDEIR.D 2 2.758 0.483 3 6.144 0.481 R.HVIILMTDGLHNMGGDPITVIDEIRDLLY 3 6.862 0.489 IGK.D R.KEVYIK.N 1 1.937 0.102 R.KNPREDYLDVYVFGVGPLVNQVNINAL 3 7.020 0.387 ASK.K R.KVGSQYR.L 2 2.309 0.199 R.PHDFENGEYWPR.S 2 2.939 0.253 R.STGSWSTLK.T 2 2.270 0.211 R.STGSWSTLKTQDQK.T 2 2.685 0.196 R.WSGQTAICDNGAGYCSNPGIPIGTR.K 2 4.008 0.473 R.YGLVTYATYPK.I 1 1.993 0.235 2 4.255 0.373 V.ASYGVKPR.Y 2 2.284 0.202 V.KDISEVVTPR.F 2 3.398 0.232 V.SEADSSNADWVTK.Q 2 3.475 0.472 Y.GLVTYATYPK.I 2 3.501 0.382 P00746 homo sapiens (human). SW:CFAD_HUMA complement factor d precursor (ec IPI:IPI00019579.1 K.VQVLLGAHSLSQPEPSKR.L 3 4.884 0.435 O, P N 3.4.21.46) (c3 convertase activator) (94%) (properdin factor d) (adipsin). 10/2001 R.AVPHPDSQPDTIDHDLLLLQLSEK.A 3 3.573 0.352 R.THHDGAITER.L 2 2.637 0.365 P08603 homo sapiens (human). SW:CFAH_HUMA IPI:IPI00029739.1 complement factor h precursor (h D.SYQYGEEVTYK.C 2 3.105 0.369 A, G, O, P N (99%) factor 1). 10/2001 K.CQKRPCGHPGDTPFGTFTLTGGNVFE 3 4.880 0.437 YGVK.A K.DGWSAQPTCIKSCDIPVFMNAR.T 2 2.940 0.130 K.EFDHNSNIR.Y 1 2.253 0.206 2 2.689 0.272 K.HGGLYHENMR.R 2 3.691 0.308 K.IDVHLVPDR.K 1 2.004 0.225 2 2.741 0.213 K.IDVHLVPDRK.K 2 2.928 0.334 K.IIYKENER.F 2 2.621 0.178 K.IVSSAMEPDR.E 2 3.011 0.271 K.IVSSAMEPDREYHFGQAVR.F 2 3.877 0.356 3 3.802 0.239 K.KEFDHNSNIR.Y 2 2.760 0.273 K.NDFTWFK.L 1 1.892 0.115 2 2.387 0.108 K.NKKEFDHNSNIR.Y 2 3.431 0.201 K.SPDVINGSPISQK.I 2 3.713 0.337 K.SPPEISHGVVAH.M 2 3.376 0.241 K.SPPEISHGVVAHMSD.S 2 3.412 0.461 K.SSIDIENGFISESQYTYALK.E 2 4.139 0.316 K.SSNLIILEEHLK.N 1 2.268 0.299 2 4.191 0.267 K.WSHPPSCIKTDCLSLPSFENAIPMGEK. 3 4.288 0.094 K K.YYGDSVE.G 1 1.964 0.147 N.PPTVQNAYIVSR.Q 2 2.255 0.108 R.CTLKPCDYPDIKHGGLYHENMR.R 3 3.989 0.133 R.EIMENYNIALR.W 2 3.760 0.374 R.EYHFGQAVR.F 2 2.630 0.236 R.KGEWVALNPLR.K 2 3.982 0.231 R.KGEWVALNPLRK.C 2 3.540 0.277 R.NTEILTGSWSDQTYPEGTQAIYK.C 2 4.802 0.478 3 3.876 0.250 R.QMSKYPSGER.V 2 2.619 0.241 R.RNTEILTGSWSDQTYPEGTQAIYK.C 3 4.577 0.328 R.RPYFPVAVGK.Y 2 3.464 0.220 Supplementary Table 1 202 R.SSQESYAHGTK.L 1 2.510 0.167 2 3.007 0.139 R.TKNDFTWFK.L 2 3.183 0.236 R.WTGRPTCRDTSCVNPPTVQNAYIVSR. 3 3.676 0.179 Q S.SQESYAHGTK.L 2 2.913 0.290 P05156 homo sapiens (human). complement factor i precursor (ec IPI:IPI00103277.1 SW:CFAI_HUMAN C.KVTYTSQEDLVEK.K 2 5.193 0.429 O, P 3.4.21.45) (c3b/c4b inactivator). (99%) 10/2001 C.KVTYTSQEDLVEKK.C 2 4.530 0.413 3 4.103 0.271 D.CITGEDEVGCAGFASVAQEETEILTAD 2 2.762 0.289 MDAER.R K.HGNTDSEGIVEVK.L 1 2.891 0.460 2 5.034 0.510 K.RAQLGDLPWQVAIK.D 2 3.553 0.291 K.VANYFDWISYHVGR.P 2 3.589 0.493 K.VANYFDWISYHVGRPFISQYNV.- 2 4.110 0.380 3 4.413 0.391 K.YISQMK.A 1 1.870 0.097 R.AQLGDLPWQVAIK.D 2 4.122 0.266 R.PFISQYNV.- 1 2.070 0.159 R.VFSLQWGEVK.L 2 3.734 0.218 P13569 homo sapiens (human). cystic fibrosis transmembrane conductance IPI:IPI00009454.1 SW:CFTR_HUMAN L.MGCDSFDQFSAER.R 1 2.317 0.282 P regulator (cftr) (camp- dependent (96%) chloride channel). 10/2001 N.SSAFFFSGFFVVF.L 2 2.593 0.122 Q9y3a4 homo sapiens (human). SW:CG96_HUMAN hypothetical protein cgi-96 Y.CTEESLSRLLSTCG.L 1 2.273 0.189 G (bk126b4.3). 10/2001 Q04984 homo sapiens (human), and bos taurus (bovine). 10 kda heat IPI:IPI00220362.1 SW:CH10_HUMAN A.TVVAVGSGSKGKGGEIQPVSV.K 2 2.420 0.195 O shock protein, mitochondrial (hsp10) (91%) (10 kda chaperonin) (cpn10). 10/2001 L.QATVVAVGSGSKGKGGEIQPVSVKVG 2 3.056 0.102 D.K P10809 homo sapiens (human). 60 kda heat shock protein, mitochondrial precursor (hsp60) (60 kda chaperonin) IPI:IPI00220705.1 SW:CH60_HUMAN L.KVGGTSDVEVNE.K 2 3.020 0.081 G (cpn60) (heat shock protein 60) (hsp- (97%) 60) (mitochondrial matrix protein p1) (p60 L.LRCIPALDSLTP.A 1 2.179 0.164 O14646 homo sapiens (human). SW:CHD1_HUMA chromodomain-helicase-dna-binding T.GATTTIYAVEADGDPNAGFEKN.K 2 3.816 0.164 O, P N protein 1 (chd-1). 7/1999 O14647 homo sapiens (human). SW:CHD2_HUMA chromodomain-helicase-dna-binding K.QVNIYRLVTKGTVEEEIIERA.K 2 3.086 0.186 A, G, O, P N protein 2 (chd-2). 7/1999 Q14839 homo sapiens (human). SW:CHD4_HUMA chromodomain helicase-dna-binding A.RQRKAFLNAIMRYGMPPQD.A 2 2.730 0.080 O N protein 4 (chd-4) (mi-2 autoantigen 218 kda protein) (mi2-beta). 10/2001 P52757 homo sapiens (human). beta- IPI:IPI00005037.1 SW:CHIO_HUMAN K.RFESIHDLVTD.G 2 2.533 0.098 P chimaerin (beta-chimerin). 10/2001 (97%) O96017 homo sapiens (human). IPI:IPI00176981.1 SW:CHK2_HUMAN serine/threonine-protein kinase chk2 Y.NRAVDCWSLGVILFICLSGY.P 2 2.781 0.116 A (96%) (ec 2.7.1.-) (cds1). 10/2001 P06276 homo sapiens (human). cholinesterase precursor (ec 3.1.1.8) IPI:IPI00182487.1 SW:CHLE_HUMAN (acylcholine acylhydrolase) (choline K.IFFPGVSEFGK.E 2 2.847 0.271 P (97%) esterase ii) (butyrylcholine esterase) (pseudocholinesterase). 10/2001 R.AILQSGSFNAPWAVTSLYEAR.N 2 4.834 0.546 P17516 homo sapiens (human). chlordecone reductase (ec 1.1.1.225) SW:CHLR_HUMA (cdr) (3-alpha-hydroxysteroid T.QRHKLWVDPNSPVLLEDPVLCALAKKH IPI:IPI00182618.1 3 3.651 0.121 O N dehydrogenase) (ec 1.1.1.50) (3- KR.T (93%) alpha-hsd) (dihydrodiol dehydrogenase 4) (dd4) (hakra). 10/2 SW:CIB2_HUMAN O60939 homo sapiens (human). S.DARLPCTFNSCYTVNHK.Q 2 2.571 0.091 A Supplementary Table 1 203 sodium channel beta-2 subunit precursor. 10/2001 P51801 homo sapiens (human). L.AGVVLEDYLDIKNFGAKVVGLSCTLAC. IPI:IPI00103241.1 SW:CICL_HUMAN chloride channel protein clc-kb (clc- 3 3.758 0.229 O, P G (96%) k2). 10/2001 P.EGIVAGGITNPIMPGGYALAGAA.A 2 2.490 0.105 P35499 homo sapiens (human). IPI:IPI00180576.1 SW:CIN4_HUMAN sodium channel protein, skeletal D.FEIFFEKWEKF.G 2 3.150 0.113 A (92%) muscle alpha-subunit. 10/2001 R.VIRLARIGRVLRLIRGAKGIRTLLFALMM 3 3.761 0.091 SLP.A Q14524 homo sapiens (human). IPI:IPI00180576.1 SW:CIN5_HUMAN sodium channel protein, cardiac D.IMYAAVDSRGYEEQPQWEYNL.Y 2 2.867 0.113 G, O (92%) muscle alpha-subunit (hh1). 10/2001 G.EDRLPKSDSEDGPRA.M 1 2.129 0.179 I.KIIGNSVGALGNLTLVLAII.V 1 2.727 0.121 O43525 homo sapiens (human). A.RRAAGAAGGGGDGGGGGGGAANPA IPI:IPI00012857.1 SW:CIQ3_HUMAN voltage-gated potassium channel 2 2.770 0.203 G GG.D (96%) protein kqt-like 3. 10/2001 P56696 homo sapiens (human). SW:CIQ4_HUMAN voltage-gated potassium channel A.PLPGPGSGSGSACGQRSS.A 1 2.095 0.150 A, G protein kqt-like 4. 10/2001 L.LFEHVQRARNGGLRPLEVRR.A 2 2.308 0.102 P51788 homo sapiens (human). IPI:IPI00020504.1 SW:CLC2_HUMAN chloride channel protein 2 (clc-2). T.KGRMLALVESPESMILL.G 1 2.418 0.150 G (91%) 10/2001 P51790 homo sapiens (human). IPI:IPI00062718.1 SW:CLC3_HUMAN chloride channel protein 3 (clc-3). M.AAVMTSKWVGDAFGREGIYEAHI.R 2 3.000 0.185 G (93%) 10/2001 P57739 homo sapiens (human). SW:CLD2_HUMAN F.FILGGLLGFI.P 1 2.268 0.089 P claudin-2. 10/2001 P51911 homo sapiens (human). IPI:IPI00021264.1 SW:CLP1_HUMAN calponin h1, smooth muscle (basic V.KYAEKQERKFEPGKLREG.R 2 2.895 0.187 O (96%) calponin) (calponin 1). 10/2001 P10909 homo sapiens (human). clusterin precursor (complement- associated protein sp-40,40) IPI:IPI00219642.1 SW:CLUS_HUMAN D.PITVTVPVEVSR.K 2 2.691 0.132 A, G, O, P (complement cytolysis inhibitor) (cli) (94%) (na1 and na2) (apolipoprotein j) (apo-j) (trpm-2). 5/2000 G.DQTVSDNELQEMSNQGSK.Y 2 5.843 0.423 3 4.470 0.418 K.EIQNAVNGVK.Q 2 2.525 0.203 K.FMETVAEK.A 1 2.518 0.106 2 2.706 0.273 K.LFDSDPITVTVPVEVSR.K 1 2.366 0.139 2 5.130 0.475 K.LFDSDPITVTVPVEVSRK.N 2 3.621 0.361 3 3.617 0.384 K.TLLSNLEEAK.K 1 2.341 0.119 2 3.100 0.188 K.TLLSNLEEAKK.K 2 2.840 0.164 K.YVNKEIQNAVNGVK.Q 2 3.285 0.217 P.HFFFPK.S 1 2.001 0.141 2 2.753 0.201 P.QDTYHYLPFSLPHR.R 3 3.556 0.278 R.ASSIIDELFQDR.F 2 4.166 0.287 R.ELDESLQVAER.L 1 2.491 0.252 2 3.844 0.318 R.EPQDTYHYLPFSLPHR.R 2 2.324 0.172 R.IDSLLENDRQQTHMLDVMQDHFSR.A 3 3.913 0.293 R.KTLLSNLEEAK.K 1 2.618 0.188 2 4.479 0.246 R.KTLLSNLEEAKK.K 2 4.049 0.283 3 4.025 0.193 R.QQTHMLDVMQDHFSR.A 2 3.287 0.342 R.SLMPFSPYEPLNFHAM.F 2 2.636 0.285 R.VTTVASHTSDSDVPSGVTEVVVK.L 2 5.526 0.443 3 4.034 0.270 S.SIIDELFQDR.F 2 3.561 0.250 Supplementary Table 1 204 V.PSGVTEVVVK.L 1 1.868 0.131 2 2.422 0.299 O75746 homo sapiens (human). SW:CMC1_HUMA calcium-binding mitochondrial carrier IPI:IPI00100754.1 N.NMELVRK.I 1 2.019 0.172 O N protein aralar1 (solute carrier family (93%) 25, member 12). 10/2001 Q9ujs0 homo sapiens (human). SW:CMC2_HUMA calcium-binding mitochondrial carrier IPI:IPI00007084.1 L.LGVAPEKAIKLTVNDFVRDK.F 2 4.052 0.107 A, O, P N protein aralar2 (solute carrier family (97%) 25, member 13) (citrin). 10/2001 3 3.983 0.103 Q14432 homo sapiens (human). cgmp-inhibited 3',5'-cyclic phosphodiesterase a (ec 3.1.4.17) SW:CN3A_HUMAN E.HLGSQLIAGTKEDI.P 2 2.995 0.165 A (cyclic gmp inhibited phosphodiesterase a) (cgi-pde a). 10/2001 I.LLARYVEQ.I 1 2.110 0.132 Q07343 homo sapiens (human). camp-dependent 3',5'-cyclic IPI:IPI00220621.1 SW:CN4B_HUMAN Y.AIFQERDLLKTFRISSDTFITY.M 2 2.868 0.104 A phosphodiesterase 4b (ec 3.1.4.17) (95%) (dpde4) (pde32). 10/2001 Q08493 homo sapiens (human). SW:CN4C_HUMA camp-dependent 3',5'-cyclic IPI:IPI00179445.1 E.RDLSPRPELR.K 1 2.096 0.123 O, P N phosphodiesterase 4c (ec 3.1.4.17) (94%) (dpde1) (pde21). 5/2000 O95263 homo sapiens (human). high- affinity camp-specific and ibmx- R.HFVSLKKLCCTTDNNKQIHKIHRDSGD IPI:IPI00216768.1 SW:CN8B_HUMAN insensitive 3',5'-cyclic 3 3.595 0.125 O NSQTEPHSFR.Y (99%) phosphodiesterase 8b (ec 3.1.4.17) (fragment). 10/2001 Q14028 homo sapiens (human). cyclic-nucleotide-gated cation channel SW:CNG4_HUMA 4 (cng channel 4) (cng-4) (cng4) V.YLPNDYVCKKGEI.G 1 2.269 0.151 G N (cyclic nucleotide-gated cation channel modulatory subunit). 10/2001 Q9h4b4 homo sapiens (human). cytokine-inducible serine/threonine- SW:CNK_HUMAN protein kinase (ec 2.7.1.37) (fgf- P.DLTPPNPARSLFAKV.T 1 2.050 0.203 A inducible kinase) (proliferation-related kinase). 10/2001 S.ALRGPELEMLAGLPTSDPGRLITDPRS 2 2.487 0.163 GRTYL.K P51160 homo sapiens (human). cone SW:CNRC_HUMA cgmp-specific 3',5'-cyclic IPI:IPI00016413.1 E.DSGGGDDKK.S 1 2.041 0.082 P N phosphodiesterase alpha'-subunit (ec (96%) 3.1.4.17). 10/2001 P26992 homo sapiens (human). ciliary SW:CNTR_HUMA IPI:IPI00003102.1 neurotrophic factor receptor alpha P.TPTYIPNTFNVTVLHGSKIMVCEK.D 3 4.034 0.096 P N (92%) precursor (cntfr alpha). 10/2001 P06681 homo sapiens (human). complement c2 precursor (ec SW:CO2_HUMAN K.ALHQVFEHMLDVSK.L 2 3.168 0.423 O 3.4.21.43) (c3/c5 convertase). 10/2001 3 3.702 0.391 K.AVISPGFDVFAK.K 1 2.007 0.139 2 2.806 0.273 K.NQGILEFYGDDIALLK.L 2 4.656 0.453 K.SSGQWQTPGATR.S 2 3.172 0.368 R.DHENELLNK.Q 2 3.232 0.257 R.EVVTDQFLCSGTQEDESPCKGESGGA 3 4.603 0.424 VFLER.R R.HAFILQDTK.A 2 2.455 0.304 R.HAIILLTDGK.S 2 3.712 0.301 R.TPWHVTIKPK.S 2 2.671 0.284 S.SGQWQTPGATR.S 2 2.747 0.166 V.FEHMLDVSK.L 2 2.212 0.323 P01024 homo sapiens (human). IPI:IPI00164623.2 SW:CO3_HUMAN complement c3 precursor [contains: A.AVYHHFISDGVR.K 2 4.299 0.433 A, G, O, P (99%) c3a anaphylatoxin]. 10/2001 A.GDFLEANYMNLQR.S 2 2.282 0.264 A.SHLGLAR.- 1 1.892 0.166 A.TVILHSGSDMVQAER.S 2 3.731 0.417
Supplementary Table 1 205 A.VYHHFISDGVR.K 1 2.601 0.333 2 3.637 0.460 A.VYHHFISDGVRK.S 2 3.001 0.291 3 3.695 0.324 C.KLVLSSEK.L 1 2.643 0.249 2 2.635 0.093 D.AGLTFTSSSGQQTA.Q 2 2.693 0.259 D.AGLTFTSSSGQQTAQR.A 2 3.808 0.401 D.IIAEENIVSR.S 1 2.462 0.162 2 3.470 0.245 D.QVPDTESETR.I 2 2.233 0.274 D.TVQSLTQGDGVAK.L 1 2.628 0.323 2 3.934 0.338 E.ETMVLEAHDAQGDVPVTVTVHDFPGK 3 3.728 0.180 K.L E.QNMIGMTPTVIAVHYLDETEQWEK.F 2 4.617 0.463 F.QALAQYQK.D 1 2.189 0.195 F.SDAGLTFTSSSGQQTAQR.A 2 4.972 0.531 F.VTNPDGSPAYR.V 2 2.433 0.223 G.SDEVQVGQQR.T 2 2.503 0.183 G.SPMYSIITPNILR.L 1 2.860 0.346 2 4.073 0.315 G.SPMYSIITPNILRLESEETMVLEAHDAQ 3 4.491 0.276 GDVPVTVTVHDFPGK.K G.SPMYSIITPNILRLESEETMVLEAHDAQ 3 4.923 0.351 GDVPVTVTVHDFPGKK.L G.YTQQLAFR.Q 2 3.309 0.279 H.DAQGDVPVTVTVHDFPGK.K 2 5.020 0.430 I.GMTPTVIAVHYLDETEQWEK.F 2 4.034 0.458 I.HWESASLLR.S 1 2.582 0.128 2 2.712 0.255 I.LRLESEETMVLEAHDAQGDVPVTVTVH 3 4.294 0.339 DFPGKK.L I.PELVNMGQWK.I 1 1.999 0.178 I.PIEDGSGEVVLSR.K 2 4.229 0.439 I.PIVTSPYQIHFTK.T 2 3.746 0.329 3 4.016 0.401 I.PPADLSDQVPDTESETR.I 2 4.848 0.489 I.VTSPYQIHFTK.T 1 1.852 0.105 K.AAVYHHF.I 2 2.433 0.199 K.AAVYHHFISDG.V 2 2.597 0.193 K.AAVYHHFISDGV.R 2 2.716 0.276 K.AAVYHHFISDGVR.K 1 2.836 0.393 2 4.628 0.428 3 3.873 0.336 K.AAVYHHFISDGVRK.S 2 3.824 0.300 3 4.044 0.291 K.AGDFLEANYMNLQ.R 2 4.708 0.263 K.AGDFLEANYMNLQR.S 1 2.822 0.156 2 4.542 0.310 K.AGDFLEANYMNLQRSYTVAIAGYALAQ 3 3.763 0.313 MGRLK.G K.DAPDHQELNLDVSLQLPSR.S 2 5.802 0.431 3 4.133 0.156 K.DFDFVPPVVR.W 1 2.340 0.180 2 2.715 0.117 K.DSITTWEILAVSMSDKK.G 2 4.161 0.476 K.DYAGVFSDAGLTFTSSSGQQTAQR.A 2 6.480 0.624 3 4.882 0.536 K.EDIPPADLSD.Q 1 1.951 0.309 2 3.267 0.297 K.EDIPPADLSDQVPDTESETR.I 2 4.870 0.350 3 4.284 0.185 K.ENEGFTVTAEGK.G 1 2.239 0.207 2 3.290 0.394 Supplementary Table 1 206 K.EYVLPSFEVIVEPTEK.F 1 3.604 0.284 2 5.753 0.441 K.FVTVQATFGTQVVEK.V 2 3.775 0.425 K.FYYIYNEK.G 1 2.556 0.154 2 2.689 0.163 K.GQGTLSVVTMYH.A 2 2.962 0.348 K.GQGTLSVVTMYHA.K 2 3.185 0.303 K.GQGTLSVVTMYHAK.A 1 2.317 0.091 2 3.727 0.471 K.GVFVLNK.K 1 2.391 0.083 K.GVFVLNKK.N 1 2.351 0.103 K.GYTQQLAFR.Q 1 1.917 0.092 2 3.338 0.169 K.GYTQQLAFRQPSSAFAAFVKR.A 3 4.328 0.376 K.HYLMWGLSSDFWGEKPNLSYIIGK.D 3 6.088 0.515 K.IRYYTYLIMNK.G 2 3.328 0.191 K.IWDVVEK.A 1 2.422 0.133 K.KGYTQQLAFR.Q 1 2.768 0.182 2 3.768 0.401 K.KGYTQQLAFRQPSSAFAAFVK.R 2 2.496 0.266 3 5.365 0.391 K.KHYLMWGLSSDFWGEKPNL.S 2 5.409 0.404 3 4.977 0.265 K.KHYLMWGLSSDFWGEKPNLSYIIGK.D 3 6.423 0.456 K.KQELSEAEQA.T 2 3.051 0.122 K.KQELSEAEQAT.R 2 3.044 0.252 K.KQELSEAEQATR.T 1 3.277 0.282 2 4.208 0.093 3 4.217 0.147 K.KVEGTAFVIFGIQDGEQR.I 2 5.503 0.423 3 4.154 0.270 K.KVFLDCCNYITELR.R 2 4.065 0.277 K.LMNIFLK.D 1 1.967 0.090 2 2.477 0.116 K.LMNIFLKDSITTWEILAVSMSDKK.G 3 5.992 0.398 K.LSINTHPSQK.P 2 3.426 0.163 K.LSINTHPSQKPL.S 1 2.678 0.219 2 2.857 0.199 K.LSINTHPSQKPLSIT.V 2 2.919 0.164 K.LSINTHPSQKPLSITV.R 1 3.340 0.272 2 3.504 0.295 3 3.653 0.373 K.LSINTHPSQKPLSITVR.T 1 3.538 0.366 2 4.514 0.452 3 5.114 0.348 K.LVLSSEK.L 1 1.855 0.106 K.PGMPFDLMVFVTNPDGSPAYR.V 2 4.925 0.420 K.QDSLSSQNQLGVLPL.S 2 2.725 0.104 K.QDSLSSQNQLGVLPLSWDIPELVN.M 2 4.451 0.328 K.QDSLSSQNQLGVLPLSWDIPELVNMG 2 3.453 0.235 QWK.I 3 5.797 0.433 K.QELSEAEQAT.R 1 1.845 0.100 K.QELSEAEQATR.T 1 2.625 0.239 2 3.800 0.216 K.QKPDGVFQEDAPVIHQEM.I 2 2.982 0.305 3 4.520 0.230 K.QKPDGVFQEDAPVIHQEMIGGLR.N 2 2.843 0.368 3 4.988 0.278 K.QLYNVEATSYALLALLQLK.D 2 5.913 0.549 3 4.897 0.366 K.QLYNVEATSYALLALLQLKDFDFVPPVV 3 5.366 0.345 R.W K.RAPSTWLTAYVVK.V 2 3.451 0.335 Supplementary Table 1 207 K.RIPIEDGSGEVVLSR.K 1 2.589 0.336 2 4.925 0.438 3 4.453 0.371 K.RIPIEDGSGEVVLSRK.V 3 4.682 0.343 K.RQGALELIK.K 2 2.931 0.112 K.SDDKVTLEER.L 1 2.216 0.086 2 3.590 0.222 K.SGQSEDRQPVPGQQMTLK.I 2 4.671 0.404 3 3.611 0.352 K.SGQSEDRQPVPGQQMTLKIEGDHGAR 3 5.214 0.363 .V K.SGSDEVQVGQ.Q 1 2.151 0.239 K.SGSDEVQVGQQ.R 2 3.389 0.173 K.SGSDEVQVGQQR.T 1 2.830 0.328 2 4.144 0.338 K.SLYVSATVILHSGSDMVQAER.S 2 5.535 0.460 3 4.687 0.470 K.SSLSVPYVIVPL.K 2 2.746 0.117 K.SSLSVPYVIVPLK.T 1 2.347 0.228 2 3.806 0.323 K.SSLSVPYVIVPLKTGLQEVEVK.A 2 3.276 0.278 K.TGLQEVEVK.A 1 2.176 0.129 2 3.824 0.300 K.TIYTPGSTVLYR.I 2 3.070 0.385 K.TIYTPGSTVLYRIFTVNHKLLPVGR.T 3 4.484 0.364 K.VEGTAFVIFGIQDGEQR.I 2 4.010 0.438 K.VFLDCCNYITELR.R 2 3.490 0.247 K.VGKYPK.E 1 1.991 0.100 K.VHQYFNVELIQPGAVK.V 1 3.162 0.227 2 4.996 0.301 3 4.907 0.123 K.VQLSNDFDEYIMAIEQTIK.S 2 6.499 0.479 3 5.609 0.330 K.VQLSNDFDEYIMAIEQTIKSGSDEVQVG 3 4.855 0.336 QQR.T K.VTIKPAPETEK.R 1 2.238 0.250 2 2.735 0.193 K.VTIKPAPETEKR.P 2 2.354 0.314 K.VTIKPAPETEKRPQDAK.N 2 3.874 0.451 K.YELDKAFSDR.N 2 3.165 0.444 K.YFKPGMPFDLMVFVTNPDGSPAY.R 2 2.835 0.119 K.YFKPGMPFDLMVFVTNPDGSPAYR.V 2 4.831 0.446 3 4.541 0.230 K.YFKPGMPFDLMVFVTNPDGSPAYRVP 3 3.820 0.287 VAVQGEDTVQSLTQGDGVAK.L L.MVFVTNPDGSPAYR.V 2 2.228 0.101 L.PSFEVIVEPTEK.F 1 2.781 0.392 L.PYSTVGNSNNYLHLSVLR.T 2 3.986 0.487 L.SINTHPSQK.P 2 2.824 0.259 L.SINTHPSQKPL.S 2 2.927 0.258 L.SINTHPSQKPLSITV.R 2 3.133 0.397 L.SINTHPSQKPLSITVR.T 2 4.093 0.503 3 4.028 0.322 L.SITTDFIPSFR.L 2 3.419 0.295 L.SSDFWGEKPNLSYIIGK.D 2 4.045 0.327 L.SSQNQLGVLPLSWDIPELVNMGQWK.I 2 3.346 0.368 L.SWDIPELVNMGQWK.I 2 2.955 0.364 L.TFTSSSGQQTAQR.A 2 3.572 0.455 L.VAYYTLIGASGQR.E 2 3.585 0.294 M.MTGFAPDTDDLK.Q 2 3.627 0.393 M.SVQLTEK.R 2 2.248 0.173 M.SVQLTEKR.M 2 2.564 0.191 M.TGFAPDTDDLK.Q 2 2.677 0.231 M.VFQALAQYQK.D 2 2.413 0.259
Supplementary Table 1 208 M.VFVTNPDGSPAYR.V 1 2.093 0.249 2 3.901 0.245 M.VFVTNPDGSPAYRVPVAVQGEDTVQS 3 5.860 0.469 LTQGDGVAK.L M.VLEAHDAQGDVPVTVTVHDFPGK.K 2 5.286 0.474 3 5.533 0.415 M.WGLSSDFWGEKPNLSYIIGK.D 2 3.710 0.307 3 4.667 0.347 N.DFDEYIMAIEQTIK.S 2 4.416 0.427 N.ILRLESEETMVLEAHDAQGDVPVTVTV 3 5.919 0.399 HDFPGK.K N.ILRLESEETMVLEAHDAQGDVPVTVTV 3 5.768 0.442 HDFPGKK.L N.PDGSPAYRVPVAVQGEDTVQSLTQGD 3 6.285 0.407 GVAK.L N.QLGVLPLSWDIPELVNMGQWK.I 2 4.112 0.469 N.SNNYLHLSVLR.T 2 2.420 0.221 N.THPSQKPLSITVR.T 2 2.756 0.234 P.GQDLVVLPLSITTDFIPSFR.L 2 4.991 0.433 P.IEDGSGEVVLSR.K 1 2.346 0.118 2 4.439 0.382 P.IEDGSGEVVLSRK.V 2 3.808 0.232 P.MYSIITPNILR.L 2 3.262 0.225 P.SSAFAAFVK.R 2 2.728 0.122 P.VAVQGEDTVQSLTQGDGVAK.L 2 5.700 0.530 Q.ELSEAEQATR.T 2 3.316 0.248 Q.GDVPVTVTVHDFPGK.K 1 2.022 0.187 Q.GEDTVQSLTQGDGVAK.L 2 4.706 0.448 Q.GTPVAQMTEDAVDAERLK.H 2 3.748 0.411 Q.MTEDAVDAER.L 1 1.938 0.234 2 3.433 0.340 R.AEDLVGKSLYVSATVILHSGSDMVQAE 3 6.560 0.410 R.S R.APSTWLTAYVVK.V 2 3.441 0.409 R.ASHLGLA.Q 1 1.824 0.352 R.ASHLGLAR.- 1 2.154 0.231 R.AVLYNYRQNQELK.V 2 4.176 0.329 R.AYYENSPQQVF.S 2 3.863 0.409 R.AYYENSPQQVFSTEFEVK.E 2 5.289 0.484 R.EALKLEEK.K 1 2.812 0.109 2 3.077 0.110 R.EGVQKEDIPPADLSDQVPDTESET.R 2 4.402 0.299 R.EGVQKEDIPPADLSDQVPDTESETR.I 2 4.639 0.447 3 5.234 0.414 R.EPGQDLVVLPLSITTDFIPSFR.L 2 4.593 0.344 R.EVVADSVWVDVK.D 1 3.257 0.303 2 3.892 0.340 R.FYHPEKEDGK.L 1 2.368 0.158 2 3.018 0.105 R.FYHPEKEDGKLNK.L 2 3.193 0.178 R.HQQTVTIPPK.S 1 2.104 0.260 2 3.302 0.306 R.HQQTVTIPPKSSLSVPYVIVPLKTGLQE 3 4.085 0.344 VEVK.A R.IFTVNHK.L 1 1.905 0.092 R.IHWESASLLR.S 1 2.850 0.399 2 2.928 0.205 R.ILLQGTPVAQMTEDAVDAER.L 2 5.926 0.513 3 6.040 0.461 R.ILLQGTPVAQMTEDAVDAERL.K 2 4.889 0.521 R.ILLQGTPVAQMTEDAVDAERLK.H 2 4.767 0.438 3 3.682 0.151 R.IPIEDGSGEVVLSR.K 1 2.607 0.341 2 4.375 0.334 R.IPIEDGSGEVVLSRK.V 2 3.501 0.407
Supplementary Table 1 209 R.LESEETMVLEAHDAQGDVPVTVT.V 2 2.910 0.228 R.LESEETMVLEAHDAQGDVPVTVTVHD 2 4.641 0.336 FPGK.K 3 6.917 0.483 R.LESEETMVLEAHDAQGDVPVTVTVHD 2 4.079 0.346 FPGKK.L 3 6.820 0.438 R.LGREGVQKEDIPPADLSDQVPDTESET 3 5.517 0.384 R.I R.LKGPLLNK.F 2 2.320 0.118 R.LKGPLLNKFLTTAK.D 2 2.562 0.294 R.LVAYYTLIGASGQR.E 1 2.186 0.125 2 4.938 0.346 R.NTLIIYLDK.V 1 2.484 0.081 2 2.678 0.122 R.QGALELIK.K 2 2.210 0.194 R.QPSSAFAAFVK.R 1 2.107 0.092 2 2.311 0.302 R.QPVPGQQMTLK.I 2 2.511 0.189 R.SEETKENEGFTVTAEGK.G 2 5.028 0.394 3 4.389 0.383 R.SEFPESWLWNVEDLK.E 2 4.611 0.393 R.SEFPESWLWNVEDLKEPPK.N 2 4.166 0.436 R.SEFPESWLWNVEDLKEPPKNGISTK.L 2 2.422 0.257 3 4.224 0.344 R.SGIPIVTSPY.Q 1 1.833 0.089 R.SGIPIVTSPYQIH.F 2 2.564 0.244 R.SGIPIVTSPYQIHF.T 1 2.737 0.304 2 3.348 0.347 R.SGIPIVTSPYQIHFT.K 2 3.461 0.293 R.SGIPIVTSPYQIHFTK.T 1 4.209 0.291 2 4.312 0.443 R.SNLDEDIIAEEN.I 2 3.008 0.122 R.SNLDEDIIAEENIVSR.S 1 3.607 0.283 2 5.746 0.362 3 5.154 0.288 R.SYTVAIAGYALAQMGR.L 2 4.092 0.455 R.TELRPGETLNVN.F 2 3.476 0.296 R.TELRPGETLNVNFLL.R 2 3.103 0.240 R.TELRPGETLNVNFLLR.M 2 4.170 0.455 3 5.606 0.376 R.TFISPIK.C 1 2.146 0.231 R.TKKQELSEAEQAT.R 2 2.765 0.289 R.TKKQELSEAEQATR.T 1 2.563 0.272 2 4.495 0.398 3 4.322 0.351 R.TMQALPYSTVGNSNNYLHLSVL.R 2 2.752 0.259 R.TMQALPYSTVGNSNNYLHLSVLR.T 2 4.482 0.493 R.TVMVNIENPEGIPVK.Q 1 3.021 0.258 2 4.659 0.323 R.TVMVNIENPEGIPVKQDSLSSQNQLGV 3 4.534 0.368 LPLSWDIPELVNMGQWK.I R.VPVAVQGE.D 1 1.837 0.310 R.VPVAVQGED.T 1 2.580 0.333 R.VPVAVQGEDTVQ.S 2 3.509 0.342 R.VPVAVQGEDTVQSL.T 2 3.568 0.252 R.VPVAVQGEDTVQSLTQGDGVA.K 2 4.474 0.442 R.VPVAVQGEDTVQSLTQGDGVAK.L 2 6.169 0.533 3 5.587 0.339 R.VVLVAVDK.G 1 2.526 0.281 2 2.708 0.199 R.VVLVAVDKGVFVLNK.K 2 5.117 0.517 3 3.761 0.369 R.VVLVAVDKGVFVLNKK.N 2 4.110 0.533 3 3.874 0.405 Supplementary Table 1 210 R.WEDPGKQLYNVEATSYALLALLQLKDF 3 5.038 0.422 DFVPPVVR.W R.YISKYELDK.A 1 2.506 0.112 2 2.679 0.203 R.YRGDQDATMSILDISM.M 2 3.385 0.377 R.YRGDQDATMSILDISMMTGFAPDTDDL 3 3.711 0.343 K.Q R.YYGGGYGSTQATF.M 2 3.987 0.449 R.YYGGGYGSTQATFMVFQALAQYQK.D 2 5.711 0.514 R.YYTYLIMNK.G 1 2.585 0.208 2 3.323 0.322 S.GIPIVTSPYQIHFTK.T 2 3.817 0.348 S.SLSVPYVIVPLK.T 2 2.912 0.239 T.GLQEVEVK.A 2 2.305 0.206 T.KKQELSEAEQATR.T 2 3.971 0.271 3 4.424 0.255 T.MVLEAHDAQGDVPVTVTVHDFPGK.K 3 3.592 0.396 T.PVAQMTEDAVDAER.L 1 2.456 0.368 2 2.660 0.279 T.PVAQMTEDAVDAERLK.H 2 3.644 0.394 T.VIAVHYLDETEQWEK.F 1 3.996 0.416 2 5.155 0.475 V.FLDCCNYITELR.R 2 3.244 0.200 V.FVTNPDGSPAYR.V 2 3.020 0.280 V.LVAVDK.G 1 1.937 0.095 V.PDTESETR.I 1 2.061 0.134 V.PVAVQGEDTVQSLTQGDGVAK.L 2 6.202 0.550 V.PVTVTVHDFPGKK.L 2 2.452 0.211 V.PYVIVPLK.T 1 2.364 0.143 V.PYVIVPLKTGLQEVEVK.A 2 3.728 0.206 V.VLVAVDK.G 1 2.436 0.143 V.YHHFISDGV.R 2 2.766 0.203 V.YHHFISDGVR.K 2 3.174 0.274 Y.ALLALLQLK.D 2 3.070 0.175 Y.HHFISDGVR.K 1 1.843 0.090 2 2.704 0.247 Y.STVGNSNNYLHLSVLR.T 2 4.225 0.336 Y.TQQLAFR.Q 2 2.418 0.265 Y.TVAIAGYALAQMGR.L 2 3.281 0.288 Y.YENSPQQVFSTEFEVK.E 2 2.245 0.276 P01028 homo sapiens (human). IPI:IPI00032258.2 SW:CO4_HUMAN complement c4 precursor [contains: A.DGSYAAWLSR.G 2 3.465 0.264 A, G, O, P (95%) c4a anaphylatoxin]. 10/2001 A.SATLYDYYNPER.R 2 3.854 0.347 A.YWIASHTTEER.G 2 2.683 0.328 D.PLDTLGSEGALSPGGVASLLR.L 2 3.534 0.167 E.QTMIYLAPTLAASR.Y 2 4.216 0.351 G.HLFLQTDQPIYNPGQR.V 2 5.187 0.417 I.PDISEPGTWK.I 1 1.985 0.221 I.PIIIPQTISELQLSVSAGSPHPAIAR.L 2 3.183 0.201 I.PQTISELQLSVSAGSPHPAIAR.L 2 3.165 0.418 I.YGKPVQGVAYVR.F 2 2.325 0.167 K.ADGSYAAWLSR.G 1 2.238 0.308 2 4.166 0.399 K.AEFQDALEK.L 1 2.359 0.097 2 2.696 0.214 K.AEFQDALEKLNMGITDLQGLR.L 3 5.407 0.328 K.AEMADQAAAWLTR.Q 2 4.248 0.326 K.AEMADQASAWLTR.Q 2 2.872 0.099 K.ASAGLLGAHAAAITAY.A 1 2.774 0.422 2 2.897 0.181 K.ASAGLLGAHAAAITAYALTLTK.A 2 6.002 0.540 3 5.330 0.418 K.ASAGLLGAHAAAITAYALTLTKAPADLR. 3 5.264 0.379 G Supplementary Table 1 211 K.DDPDAPLQPVTPLQLFEGR.R 2 4.311 0.323 3 3.784 0.360 K.DHAVDLIQK.G 1 2.877 0.215 2 3.699 0.253 K.EGAIHREELVYELNPLDHR.G 2 3.773 0.336 3 5.436 0.344 K.EVYMPSSIFQDDFVIPDISEPGTWK.I 2 4.125 0.432 3 4.545 0.216 K.ITPGKPYILTVPGHLDEM.Q 2 2.975 0.298 K.ITPGKPYILTVPGHLDEMQLDIQAR.Y 2 3.731 0.349 3 5.069 0.369 K.ITQVLHFTK.D 1 2.364 0.245 2 3.311 0.273 K.KYVLPNFEVK.I 1 2.639 0.136 2 3.786 0.290 K.LGQYASPTAK.R 1 2.404 0.270 2 3.215 0.323 K.LHLETDSLALVALGALDTALYAAGSK.S 2 2.951 0.310 3 5.691 0.445 K.LNMGITDLQGLR.L 2 4.077 0.314 K.LQETSNWLLSQQQADGSFQDLSPVIH 2 3.478 0.415 R.S 3 6.504 0.360 K.LVNGQSHISLSK.A 2 3.591 0.406 K.MRPSTDTITVMVENSHGLR.V 2 3.215 0.331 3 5.467 0.415 K.PVQGVAYVR.F 1 2.517 0.314 2 3.013 0.296 K.SHALQLNN.R 2 2.648 0.114 K.SHALQLNNR.Q 1 2.540 0.318 2 2.867 0.295 K.SHKPLNMGK.V 2 2.847 0.221 K.TEQWSTLPPETK.D 1 1.863 0.214 2 4.013 0.347 K.VDFTLSSER.D 2 2.917 0.283 K.VDFTLSSERDFALLSLQVPLKDAK.S 3 4.868 0.278 K.VGGNSKGTLKVLR.T 2 2.741 0.277 K.VGLSGMAIADVTLLSGFHALR.A 3 4.492 0.352 K.VLQIEKEGAIHREELVYELNPLDHR.G 3 5.584 0.462 K.VLSLAQEQVGGSPEK.L 1 3.267 0.369 2 5.070 0.421 K.VLSLAQEQVGGSPEKLQETSNWLLSQ 3 4.551 0.314 QQADGSFQDLSPVIHR.S K.VSATVSSPGSVPEVQDIQQN.T 2 2.641 0.246 K.YVLPNFEVK.I 1 2.433 0.095 2 2.685 0.195 L.GQYASPTAK.R 1 1.819 0.146 L.NMGITDLQGLR.L 2 2.999 0.231 L.SAYWIASHTTEER.G 2 3.782 0.360 L.SVSAGSPHPAIAR.L 2 3.180 0.385 L.VQPASATLYDYYNPER.R 2 3.359 0.481 M.AIADVTLLSGFHALR.A 2 3.455 0.475 M.RPSTDTITVMVENSHGLR.V 3 4.852 0.290 P.EVQLVAHSPWLK.D 1 1.937 0.207 2 4.261 0.341 R.ALEILQEED.L 1 2.108 0.091 R.ALEILQEEDLIDEDDIPVR.S 2 5.633 0.328 3 3.799 0.173 R.AVGSGATFSHYYYM.I 2 2.507 0.233 R.AVGSGATFSHYYYMILSR.G 2 4.913 0.514 R.DFALLSLQVPLK.D 2 4.678 0.230 R.DFALLSLQVPLKDAK.S 2 4.521 0.355 R.DKGQAGLQR.A 2 2.689 0.115 R.DSSTWLTAFVLK.V 2 3.833 0.201 Supplementary Table 1 212 R.EAPKVVEEQESR.V 2 3.044 0.329 R.EELVYELNPLDHR.G 2 4.127 0.392 R.EMSGSPASGIPVK.V 1 2.421 0.111 2 3.368 0.399 R.EPFLSCCQFAESLR.K 2 2.852 0.101 R.FGLLDEDGK.K 1 2.644 0.166 R.FGLLDEDGKK.T 1 2.982 0.196 2 3.410 0.161 R.GHLFLQTDQPIYN.P 2 2.761 0.251 R.GHLFLQTDQPIYNPGQ.R 2 2.639 0.194 R.GHLFLQTDQPIYNPGQR.V 2 6.657 0.507 3 4.722 0.238 R.GLEEELQFSLGSK.I 1 2.479 0.102 2 4.908 0.464 R.GLQDEDGYR.M 1 2.218 0.187 2 2.801 0.242 R.GPEVQLVAHSPWLK.D 1 3.199 0.396 2 4.771 0.439 R.GSFEFPVGDAVSK.V 1 3.061 0.347 2 3.712 0.378 R.GSSTWLTAFVLK.V 2 3.741 0.371 R.HLVPGAPFLLQAL.V 2 2.608 0.178 R.HLVPGAPFLLQALV.R 2 2.790 0.315 R.HLVPGAPFLLQALVR.E 1 2.708 0.176 2 3.252 0.131 3 5.125 0.283 R.KADGSYAAWLSR.G 2 4.333 0.375 R.KKEVYMPSSIFQDDFVIPDISEPGTWK.I 2 3.850 0.378 3 4.682 0.363 R.LEPGKEYLIMGLDGATYDLEGHPQYLL 3 5.648 0.443 DSNSWIEEMPSER.L R.LLLFSPSVVHLGVPLSVGVQLQDVPR. 2 2.910 0.232 G 3 6.548 0.402 R.LLLFSPSVVHLGVPLSVGVQLQDVPRG 3 5.206 0.464 QVVK.G R.LRLEPGKEYLIMGLDGATYDLEGHPQY 3 3.807 0.273 LLDSNSWIEEMPSER.L R.LTVAAPPSGGPGFLSIER.P 2 3.239 0.293 R.NVNFQK.A 1 2.206 0.120 R.PVAFSVVPTAAAAVSLK.V 2 3.798 0.433 3 3.882 0.378 R.QGSFQGGFR.S 2 2.965 0.231 R.RGHLFLQTDQPIYNPGQR.V 2 4.899 0.404 3 5.528 0.478 R.SFFPENWLWR.V 2 3.332 0.170 R.SMQGGLVGNDETVALTAFVTIALHHGL 3 5.661 0.391 AVFQDEGAEPLK.Q R.STQDTVIALDAL.S 2 3.873 0.136 R.STQDTVIALDALSAY.W 2 2.922 0.358 R.STQDTVIALDALSAYWIASHTTEER.G 2 3.788 0.198 3 4.122 0.304 R.TLEIPGNSDPNMIPDGDFNSY.V 2 2.909 0.229 R.TLEIPGNSDPNMIPDGDFNSYV.R 2 3.136 0.095 R.TLEIPGNSDPNMIPDGDFNSYVR.V 2 4.253 0.282 R.TTNIQGINLL.F 2 2.586 0.121 R.TTNIQGINLLFS.S 2 2.846 0.200 R.TTNIQGINLLFSS.R 2 3.485 0.205 R.TTNIQGINLLFSSR.R 2 4.936 0.359 R.TYNVLDMK.N 1 2.573 0.167 2 2.683 0.239 R.VEASISK.A 1 2.310 0.163 R.VETVDRFQILTLWLPDSLTTWEIHGLSL 3 5.882 0.376 SK.T R.VEYGFQVK.V 1 2.251 0.163
Supplementary Table 1 213 2 2.373 0.178 R.VFALDQK.M 1 2.409 0.155 2 2.242 0.214 R.VGDTLNLNLR.A 2 3.892 0.230 R.VTASDPLDTLGSEGALSPGGVAS.L 2 3.493 0.180 R.VTASDPLDTLGSEGALSPGGVASL.L 2 3.437 0.269 R.VTASDPLDTLGSEGALSPGGVASLL.R 2 2.567 0.401 R.VTASDPLDTLGSEGALSPGGVASLLR.L 2 6.614 0.446 3 4.640 0.090 R.YIYGKPVQGVAY.V 2 3.285 0.350 R.YIYGKPVQGVAYV.R 2 3.556 0.362 R.YIYGKPVQGVAYVR.F 2 3.875 0.517 R.YLDKTEQWSTLPPETK.D 2 4.351 0.357 R.YLDKTEQWSTLPPETKDHAVDLIQK.G 3 5.347 0.311 R.YRVFALDQK.M 2 2.563 0.223 R.YVSHFETEGPHVLLYFDSVPTSR.E 2 5.760 0.482 3 5.164 0.409 S.HALQLNNR.Q 2 2.514 0.095 S.PASGIPVK.V 1 1.990 0.097 S.PGGVASLLR.L 1 1.813 0.195 2 2.752 0.211 S.SIFQDDFVIPDISEPGTWK.I 2 4.035 0.411 Y.IYGKPVQGVAYVR.F 2 2.992 0.241 Y.MPSSIFQDDFVIPDISEPGTWK.I 2 2.944 0.355 Y.RVFALDQK.M 2 2.925 0.090 Y.WIASHTTEER.G 2 2.970 0.360 P01031 homo sapiens (human). IPI:IPI00032291.1 SW:CO5_HUMAN complement c5 precursor [contains: G.FLFIHTDKPVYTPDQSVK.V 2 2.688 0.232 G, O, P (97%) c5a anaphylatoxin]. 10/2001 K.ALVEGVDQLFTDYQIK.D 2 2.285 0.271 K.DINYVNPVIK.W 1 3.218 0.092 2 3.004 0.081 K.EGMLSIMSYR.N 2 2.271 0.207 K.ELSYYSLEDLNNK.Y 2 3.178 0.241 K.ENSQYQPIK.L 2 2.443 0.155 K.FQNSAILTIQPK.Q 2 3.963 0.360 K.FSDASYQSINIPVTQNMVPSSR.L 2 4.443 0.415 K.FSYSSGHVHLSSENK.F 2 4.933 0.421 K.IDTQDIEASHYR.G 2 4.343 0.421 K.IEEIAAK.Y 1 2.234 0.084 K.KIEEIAAK.Y 2 3.248 0.156 K.LNLVATPLFLKPGIPYPIK.V 2 4.049 0.401 K.QLPGGQNPVSYVYLEVVSK.H 2 2.537 0.376 K.RMPITYDNGFLFIHTDKPVYTPDQSVK. 3 5.536 0.443 V K.TDAPDLPEENQAR.E 2 3.069 0.206 K.TGEAVAEKDSEITFIK.K 2 3.096 0.423 K.TLLPVSKPEIR.S 2 3.199 0.270 K.YVLSPYK.L 1 1.936 0.132 Q.TIDVNQETSDLDPSK.S 2 3.489 0.398 R.EESSSGSSHAVMDISLPTGISANEEDL 3 4.102 0.324 K.A R.ESYSGVTLDPR.G 2 3.459 0.357 R.MPITYDNGFLFIHTDKPVYTPDQSVK.V 3 4.130 0.333 R.NADYSYSVWK.G 2 3.083 0.383 R.VFQFLEK.S 1 2.381 0.098 R.VYSLNDDLKPAK.R 2 3.596 0.254 R.VYSLNDDLKPAKR.E 2 3.230 0.392 P13671 homo sapiens (human). IPI:IPI00009920.1 SW:CO6_HUMAN complement component c6 precursor. K.AKDLHLSDVFLK.A 2 2.811 0.237 G, O, P (98%) 10/2001 K.ALNHLPLEYNSALYSR.I 2 3.393 0.328 3 4.175 0.309 K.DLHLSDVFLK.A 2 2.790 0.295 K.DLTSLGHNENQQGSFSSQGGSSFSVPI 3 5.164 0.454 Supplementary Table 1 214 FYSSK.R K.ENPAVIDFELAPIVDLVR.N 2 5.331 0.380 3 4.018 0.271 K.HEGSFIQGAEK.S 1 3.092 0.108 2 3.524 0.365 K.LSEKHEGSFIQGAEK.S 2 2.630 0.234 3 4.088 0.291 K.RSENINHNSAFK.Q 2 3.899 0.383 3 3.618 0.238 K.TFSEWLESVK.E 2 2.925 0.226 N.SAFKQAIQASHKKDSSFIRIHK.V 2 2.559 0.140 P.CIPSKLCKIEEADCKNK.F 2 3.462 0.108 R.KLECNGENDCGDNSDER.D 2 3.712 0.353 R.KMEILHPGK.C 2 2.538 0.202 R.KYNPIPSVQLMGNGFHFLAGEPR.G 3 3.900 0.094 R.SENINHNSAFK.Q 2 3.864 0.355 R.SEYGAALAWEK.G 2 3.175 0.141 R.VPANLENVGFEVQTAEDDLK.T 2 5.484 0.470 3 4.036 0.321 R.VPANLENVGFEVQTAEDDLKTDFYK.D 3 5.873 0.389 P10643 homo sapiens (human). IPI:IPI00217353.1 SW:CO7_HUMAN complement component c7 precursor. K.AASGTQNNVLR.G 2 3.139 0.210 O, P (92%) 10/2001 R.GGGAGFISGLSYLELDNPAGNK.R 2 5.289 0.450 R.LIDQYGTHYLQSGSLGGEYR.V 2 4.645 0.347 3 3.796 0.232 R.SYTSHTNEIHK.G 2 3.856 0.369 R.VLFYVDSEK.L 2 2.395 0.165 R.YSAWAESVTNLPQVIK.Q 2 3.212 0.387 P07357 homo sapiens (human). SW:CO8A_HUMA IPI:IPI00011252.1 complement component c8 alpha K.AMAVEDIISR.V 1 2.054 0.215 O, P N (92%) chain precursor. 10/2001 2 3.800 0.333 K.VQTAHFK.M 2 2.248 0.115 K.YHFEALADTGISSEFYDNANDLLSK.V 3 3.959 0.274 K.YNPVVIDFEMQPIHEVLR.H 2 4.946 0.469 R.HTSLGPLEAK.R 1 2.824 0.302 2 3.225 0.385 R.KDDIMLDEGMLQSLMELPDQYNYGMY 3 5.234 0.376 AK.F R.LYYGDDEK.Y 1 1.807 0.142 P07358 homo sapiens (human). SW:CO8B_HUMA IPI:IPI00011254.2 complement component c8 beta chain K.EYESYSDFER.N 2 2.640 0.349 G, O, P N (97%) precursor. 10/2001 K.IPGIFELGISSQSDR.G 2 3.613 0.416 K.RLPLEYSYGEYR.D 2 2.802 0.223 K.VEPLYELVTATDFAYSSTVR.Q 2 5.298 0.487 3 4.438 0.351 P.GIFELGISSQSDR.G 2 4.240 0.438 R.DTMVEDLVVLVR.G 2 4.045 0.311 R.FRKPYNVESYTPQTQGK.Y 2 5.033 0.441 3 4.402 0.241 R.GGASEHITTLAYQELPTADLMQEWGD 3 6.258 0.501 AVQYNPAIIK.V R.KNTPIDGK.W 2 2.513 0.161 R.KPYNVESYTPQTQGK.Y 2 4.680 0.493 R.LPLEYSYGEYR.D 2 3.187 0.345 R.SDLEVAHYK.L 2 2.877 0.153 R.SLMLHYEFLQR.V 2 2.487 0.263 Y.NVESYTPQTQGK.Y 2 3.249 0.398 P07360 homo sapiens (human). SW:CO8G_HUMA IPI:IPI00011261.1 complement component c8 gamma R.AEATTLHVAPQGTAMAVSTFR.K 2 4.419 0.303 O, P N (92%) chain precursor. 10/2001 3 3.814 0.309 R.QLYGDTGVLGR.F 2 3.014 0.315 R.RPASPISTIQPK.A 2 3.570 0.240 Supplementary Table 1 215 R.SLPVSDSVLSGFEQR.V 2 4.453 0.500 R.VQEAHLTEDQIFYFPK.Y 2 5.327 0.445 P02748 homo sapiens (human). IPI:IPI00022395.1 SW:CO9_HUMAN complement component c9 precursor. A.IEDYINEFSVR.K 2 3.248 0.353 O, P (96%) 10/2001 K.ISEGLPALEFPN.E 2 2.863 0.165 K.ISEGLPALEFPNE.K 2 4.235 0.266 K.ISEGLPALEFPNEK.- 2 3.018 0.381 K.LSPIYNLVPVK.M 2 3.048 0.405 L.SPIYNLVPVK.M 2 3.327 0.150 P.WNVASLIYETK.G 2 3.939 0.182 R.AIEDYINEFSVR.K 1 2.179 0.086 2 4.330 0.344 R.DGNTLTYYR.R 2 2.353 0.111 R.DRDGNTLTYYR.R 2 3.321 0.111 R.DRVVEESELAR.T 2 3.706 0.335 R.GTVIDVTDFVNWASSINDAPVLISQK.L 2 4.197 0.463 3 5.118 0.394 R.RPWNVASLIYETK.G 2 4.428 0.278 R.TEHYEEQIEAFK.S 1 3.395 0.284 2 4.258 0.405 3 3.674 0.165 R.VVEESELAR.T 1 2.454 0.170 2 3.241 0.304 O00763 homo sapiens (human). SW:COA2_HUMA acetyl-coa carboxylase 2 (ec 6.4.1.2) IPI:IPI00013003.1 L.HSLERGQVLPADSLLNL.V 1 2.188 0.172 G N (acc-beta) [includes: biotin (98%) carboxylase (ec 6.3.4.14)]. 10/2001 T.PLFSEARTSLYSEDDCKSLR.E 2 2.596 0.100 P49747 homo sapiens (human). SW:COMP_HUMA cartilage oligomeric matrix protein K.SSTGPGEQLR.N 2 2.347 0.183 O, P N precursor (comp). 10/2001 N.CPRVPNSDQKDSDGDGIGDACDNCP. 2 3.391 0.118 Q R.AFQTVVLDPEGDAQIDPNWVVLNQGR. 2 3.609 0.381 E 3 3.548 0.267 R.NALWHTGDTESQVR.L 2 3.255 0.427 P21964 homo sapiens (human). catechol o-methyltransferase, SW:COMT_HUMA membrane-bound form (ec 2.1.1.6) IPI:IPI00011284.1 K.DKVTLVVGASQ.D 1 1.855 0.111 O N (mb-comt) [contains: catechol o- (92%) methyltransferase, soluble form (s- comt)]. 10/2001 P53618 homo sapiens (human). SW:COPB_HUMA IPI:IPI00022778.1 coatomer beta subunit (beta-coat G.EIPIVESEIKK.E 1 2.601 0.121 G N (96%) protein) (beta-cop). 10/2001 P24462 homo sapiens (human). IPI:IPI00164895.1 SW:CP37_HUMAN cytochrome p450 3a7 (ec 1.14.14.1) T.HGLFKKLGIPGPTPLPFLGNALSF.R 2 2.475 0.273 A, O (97%) (cypiiia7) (p450-hfla). 12/1998 V.FGAYSMDVITSTSFGVSID.S 1 2.131 0.085 P13584 homo sapiens (human). IPI:IPI00009470.1 SW:CP4B_HUMAN cytochrome p450 4b1 (ec 1.14.14.1) V.REILGDQDFFQW.D 2 3.037 0.102 O, P (96%) (cypivb1) (p450-hp). 12/1998 Q02928 homo sapiens (human). cytochrome p450 4a11 precursor (ec 1.14.15.3) (cypiva11) (fatty acid L.LSIYGLHHNPKVWPNPEVFDPFRFAPG. IPI:IPI00027455.1 SW:CP4Y_HUMAN 3 3.804 0.104 O omega-hydroxylase) (p-450 hk S (95%) omega) (lauric acid omega- hydroxylase) (cyp4aii) (p450-hl-ome P22680 homo sapiens (human). cytochrome p450 7a1 (cholesterol 7- SW:CP7A_HUMAN alpha-monooxygenase) (cypvii) (ec L.EFLRANQRKH.G 2 2.786 0.211 A 1.14.13.17) (cholesterol 7-alpha- hydroxylase). 5/2000 P20813 homo sapiens (human). IPI:IPI00025829.1 SW:CPB6_HUMAN cytochrome p450 2b6 (ec 1.14.14.1) R.QVYKNLQEINAYIGHSVEKHR.E 2 2.503 0.127 G (96%) (cypiib6) (p450 iib1). 10/2001 Q99612 homo sapiens (human). core SW:CPBP_HUMA promoter element-binding protein (b- D.SQEDLWTKIILAREKKEES.E 2 3.001 0.100 A, G N cell derived protein 1) (proto- oncogene bcd1) (krueppel-like factor Supplementary Table 1 216 zf9) (transcription factor zf9) (gc-rich sites bin K.FTSDPIGEVL.V 1 2.132 0.093 P11713 homo sapiens (human). cytochrome p450 2c10 (ec 1.14.14.1) SW:CPCA_HUMA IPI:IPI00007220.1 (cypiic10) (p450 mp-8) (s- V.VLHGYEAVKEALIDLGEEFSG.R 2 2.960 0.202 O, P N (97%) mephenytoin 4-hydroxylase) (p- 450mp). 12/1998 P78329 homo sapiens (human). cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- IPI:IPI00019160.1 SW:CPF2_HUMAN H.RRMLTPAFHFNILKPYMKIFNESV.N 2 2.449 0.103 A, G hydroxylase) (leukotriene-b4 20- (95%) monooxygenase) (cytochrome p450- ltb-omega). 10/2001 L.TPAFHFNILKPYMKIFNES.V 2 2.933 0.132 M.AEMKVVLALTLLRFR.V 2 2.233 0.133 Q10570 homo sapiens (human). SW:CPSA_HUMA cleavage and polyadenylation IPI:IPI00026219.2 R.MTGEEKEFETIE.R 2 2.590 0.114 G, P N specificity factor, 160 kda subunit (96%) (cpsf 160 kda subunit). 10/2001 Y.DMWTVIAPVRKEEEDNPK.G 2 2.410 0.127 P23786 homo sapiens (human). carnitine o-palmitoyltransferase ii, IPI:IPI00012912.1 SW:CPT2_HUMAN A.QKPLLNDGQFRKTEQFCKSFEN.G 2 2.667 0.103 A mitochondrial precursor (ec 2.3.1.21) (98%) (cpt ii). 10/2001 P82279 homo sapiens (human). SW:CRBH_HUMA IPI:IPI00015785.1 crumbs protein homolog 1 precursor. K.IDWNHITLENISSGSSLNVK.A 2 3.008 0.080 O, P N (98%) 10/2001 V.KFVLNDGNVHLISL.K 2 2.713 0.088 P23508 homo sapiens (human). SW:CRCM_HUMA colorectal mutant cancer protein (mcc S.SIGVSSSVAEHLAHSLQDCSNI.Q 2 3.122 0.178 G N protein). 10/2001 Q9y2g2 homo sapiens (human). card SW:CRD8_HUMA IPI:IPI00032131.1 domain protein 8 (apoptotic protein E.PIQLEITEKR.H 2 2.977 0.152 G, O N (96%) ndpp1) (dacar). 10/2001 P13385 homo sapiens (human). teratocarcinoma-derived growth factor IPI:IPI00020964.1 SW:CRI1_HUMAN 1 (epidermal growth factor-like cripto S.YSVIWIMAISK.A 1 1.893 0.086 A (96%) protein cr1) (cripto-1 growth factor) (crgf). 10/2001 P02741 homo sapiens (human). c- IPI:IPI00181794.1 SW:CRP_HUMAN K.ESDTSYVSLK.A 1 2.058 0.144 O, P reactive protein precursor. 5/2000 (93%) K.YEVQGEVFTKPQLWP.- 2 3.446 0.289 R.KAFVFPK.E 2 2.820 0.192 S.PDEINTIYLGGPFSPNVLNWR.A 2 2.505 0.144 P27797 homo sapiens (human). calreticulin precursor (crp55) SW:CRTC_HUMA IPI:IPI00020599.1 (calregulin) (hacbp) (erp60) (52 kda E.IDNPEYSPDPSIYAYDNFGV.L 2 2.805 0.096 O N (95%) ribonucleoprotein autoantigen ro/ss-a). 10/2001 P49585 homo sapiens (human). cholinephosphate cytidylyltransferase a (ec 2.7.7.15) (phosphorylcholine SW:CTPT_HUMAN A.VQHCRYVDEVVRNAPWTLTP.E 2 2.473 0.129 G, O transferase a) (ctp:phosphocholine cytidylyltransferase a) (ct a) (cct a) (cct-alpha). K.GRMLQAISPK.Q 1 2.130 0.128 P30825 homo sapiens (human). high- affinity cationic amino acid transporter- 1 (cat-1) (cat1) (system y+ basic IPI:IPI00027728.1 SW:CTR1_HUMAN F.AVIIILILTGLLTLGVK.E 1 2.762 0.081 G amino acid transporter) (ecotropic (93%) retroviral leukemia receptor homolog) (err) O14578 homo sapiens (human). citron SW:CTRO_HUMA protein (rho-interacting, K.YIVLEGSKVLIY.D 1 2.059 0.178 A N serine/threonine kinase 21) (fragment). 10/2001 R.LTQGLQEALDRADLLKTER.S 2 2.252 0.197 Q13617 homo sapiens (human). cullin SW:CUL2_HUMAN K.FNNFIKNQDTVIDLGISFQ.I 2 3.323 0.082 O homolog 2 (cul-2). 10/2001 O75665 homo sapiens (human). IPI:IPI00221364.1 SW:CX05_HUMAN Q.SLAITKQNHMLNEKVK.E 1 2.524 0.116 G protein cxorf5 (protein 71-7a). 10/2001 (94%) P17302 homo sapiens (human). gap IPI:IPI00218487.1 SW:CXA1_HUMAN junction alpha-1 protein (connexin 43) V.DMHLKQIEIKKFKYGIEE.H 2 2.602 0.114 A (92%) (cx43) (gap junction 43 kda heart Supplementary Table 1 217 protein). 10/2001 P35212 homo sapiens (human). gap SW:CXA4_HUMAN junction alpha-4 protein (connexin 37) R.ALPAKDPQ.V 1 1.864 0.093 O, P (cx37). 10/2001 SW:CYCK_HUMA O75909 homo sapiens (human). cyclin Y.VTGACCLFLAGK.V 2 2.587 0.092 O N k. 10/2001 Q02846 homo sapiens (human). retinal guanylyl cyclase 1 precursor SW:CYGD_HUMA (ec 4.6.1.2) (guanylate cyclase 2d, D.GPRVTAVIMVMHSVLLGGEEQR.Y 2 2.221 0.103 O, P N retinal) (retgc-1) (rod outer segment membrane guanylate cyclase) (ros- gc). 10/2001 P.SCWFDPNNICGGGLEPGLVFLGFLLV. 2 2.540 0.168 V P04080 homo sapiens (human). SW:CYTB_HUMAN cystatin b (liver thiol proteinase K.AVSFKSQVVAGTN.Y 1 1.888 0.088 G inhibitor) (cpi-b) (stefin b). 10/2001 P98082 homo sapiens (human). SW:DAB2_HUMAN disabled homolog 2 (differentially F.KDFQLRQPPAVPARKGEQ.T 2 3.259 0.082 G expressed protein 2) (doc-2). 10/2001 P53355 homo sapiens (human). SW:DAPK_HUMA IPI:IPI00021250.1 death-associated protein kinase 1 (ec K.PKDTQQALSRKASAVNME.K 1 2.342 0.167 A N (96%) 2.7.1.-) (dap kinase 1). 10/2001 Q05329 homo sapiens (human). glutamate decarboxylase, 65 kda R.AWCQVAQKFTGGIGNKLCALLYGDAE IPI:IPI00012796.1 SW:DCE2_HUMAN 3 4.131 0.129 A isoform (ec 4.1.1.15) (gad-65) (65 kda K.P (91%) glutamic acid decarboxylase). 2/1996 O15075 homo sapiens (human). serine/threonine-protein kinase IPI:IPI00217248.1 SW:DCK1_HUMAN F.RGSGDDQEVLFDQILM.G 2 2.965 0.128 G, O dcamkl1 (ec 2.7.1.-) (doublecortin- like (95%) and cam kinase-like 1). 10/2001 V.HRDIKPENLLVYEHQDGSKSLK.L 3 4.089 0.196 Q9nvp1 homo sapiens (human). atp- dependent rna helicase ddx18 (dead- SW:DD18_HUMAN A.MQTFGVLKELMT.H 2 2.997 0.176 A, G box protein 18) (myc-regulated dead- box protein) (mrdb). 10/2001 L.KFQGASNLTLSETQNGD.V 1 2.638 0.101 Y.GLIMGGSNRSAEAQKLGNGI.N 2 2.470 0.193 Q14562 homo sapiens (human). atp- SW:DDX8_HUMAN dependent helicase ddx8 (rna helicase E.LDNHLGINDKDLAEFVIS.L 2 3.355 0.121 A, O, P hrh1) (deah-box protein 8). 10/2001 I.LPKVDDEEDE.D 1 2.068 0.125 I.SNLLRLIQTMRPPAKPSTSK.D 2 2.255 0.114 Q08211 homo sapiens (human). atp- dependent rna helicase a (nuclear dna IPI:IPI00155723.1 SW:DDX9_HUMAN V.IEAEHTLRELDALDAN.D 1 2.594 0.143 G, O helicase ii) (ndh ii) (dead-box protein (99%) 9). 10/2001 2 2.957 0.111 Q07507 homo sapiens (human). SW:DERM_HUMA D.RQWNYACMPTPQSLGEPTECWWEEI IPI:IPI00018036.2 dermatopontin precursor (tyrosine rich 3 3.833 0.170 O N NR.A (91%) acidic matrix protein) (tramp). 10/2001 P00352 homo sapiens (human). aldehyde dehydrogenase 1a1 (ec SW:DHA1_HUMAN 1.2.1.3) (aldehyde dehydrogenase, F.GGFKMSGNGRELGEYGFH.E 2 2.650 0.138 A, G, O, P cytosolic) (aldh class 1) (alhdii) (aldh- e1). 10/2001 R.IFVEESIYDEFVRRSVER.A 2 2.640 0.190 T.AGAAISSHMDIDK.V 2 2.952 0.100 P47895 homo sapiens (human). SW:DHA6_HUMAN aldehyde dehydrogenase 6 (ec A.AFQRGSPWRRLDALSR.G 2 2.828 0.097 O 1.2.1.5). 10/2001 O75828 homo sapiens (human). SW:DHC3_HUMA carbonyl reductase [nadph] 3 (ec K.SDDPMPFDIKAEMTLKTNFFATRNMCN 3 4.041 0.091 A N 1.1.1.184) (nadph-dependent carbonyl EL.L reductase 3). 10/2001 P00367 homo sapiens (human). glutamate dehydrogenase 1, IPI:IPI00027146.1 SW:DHE3_HUMAN E.KVFKVYNEAGV.T 1 2.718 0.106 O, P mitochondrial precursor (ec 1.4.1.3) (97%) (gdh). 10/2001 O75190 homo sapiens (human). dnaj homolog subfamily b member 6 (heat SW:DJB6_HUMAN F.PSFGSGFSSFDTGFTSFGSLG.H 2 3.234 0.286 A shock protein j2) (hsj-2) (msj-1) (hhdj1) (mrj). 10/2001 P51530 homo sapiens (human). dna2- IPI:IPI00216142.1 SW:DN2L_HUMAN E.QEICRSKSIKSLALLEELY.N 2 2.579 0.215 A, O like homolog (dna replication helicase- (97%) Supplementary Table 1 218 like homolog) (fragment). 10/2001 K.VVASFPRTVLST.G 1 1.852 0.095 P18858 homo sapiens (human). dna ligase i (ec 6.5.1.1) SW:DNL1_HUMAN E.ARFIARSLSGRL.R 2 2.863 0.103 G, O, P (polydeoxyribonucleotide synthase [atp]). 10/2001 S.EVLKRFEEAAFTCEYK.Y 2 2.400 0.117 P26358 homo sapiens (human). dna (cytosine-5)-methyltransferase 1 (ec SW:DNM1_HUMA IPI:IPI00220919.1 2.1.1.37) (dna methyltransferase hsai) V.KFGGSGRSKQACQERR.C 1 2.368 0.091 O N (97%) (dna mtase hsai) (mcmt) (m.hsai). 10/2001 O60673 homo sapiens (human). dna SW:DPOZ_HUMA IPI:IPI00219007.1 polymerase zeta catalytic subunit (ec D.NANNIQRNYLSSIGKLSEY.R 2 2.824 0.086 G N (94%) 2.7.7.7) (hrev3). 10/2001 Q16555 homo sapiens (human). dihydropyrimidinase related protein-2 IPI:IPI00002900.1 SW:DPY2_HUMAN A.AAFVTSPPLSPDPTTPDFLNS.L 2 2.937 0.126 G, P (drp-2) (collapsin response mediator (97%) protein 2) (crmp-2) (n2a3). 10/2001 D.ISEWHKGIQEEMEALVKDHGVN.S 2 3.105 0.121 Q12882 homo sapiens (human). dihydropyrimidine dehydrogenase SW:DPYD_HUMA [nadp+] precursor (ec 1.3.1.2) (dpd) IPI:IPI00029772.1 E.KGYKAAFI.G 1 2.058 0.107 A N (dhpdhase) (dihydrouracil (98%) dehydrogenase) (dihydrothymine dehydrogenase). 10/2001 P55039 homo sapiens (human). SW:DRG2_HUMA developmentally regulated gtp-binding M.KLNLDYLLEMLWEYL.A 1 2.498 0.133 A N protein 2 (drg 2). 10/2001 Q13474 homo sapiens (human). IPI:IPI00219652.1 SW:DRP2_HUMAN F.NEHDLQASEHVMDVVEVI.H 2 2.993 0.174 A dystrophin-related protein 2. 10/2001 (95%) P01880 homo sapiens (human). ig IPI:IPI00163446.1 SW:DTC_HUMAN K.VPTGGVEEGLLER.H 2 3.861 0.395 O, P delta chain c region. 10/2001 (94%) P.TGGVEEGLLER.H 2 3.048 0.298 R.DSYYMTSSQLSTPLQQWR.Q 2 5.225 0.419 R.SLEVSYVTDHGPM.K 1 2.791 0.321 2 4.462 0.412 Q99956 homo sapiens (human). dual specificity protein phosphatase 9 (ec 3.1.3.48) (ec 3.1.3.16) (mitogen- IPI:IPI00184084.1 SW:DUS9_HUMAN A.EAEEWEAESVLGTLLQK.L 2 2.928 0.110 O activated protein kinase phosphatase (92%) 4) (map kinase phosphatase 4) (mkp- 4). 10/2001 Q13409 homo sapiens (human). dynein intermediate chain 2, cytosolic IPI:IPI00176747.1 SW:DYI2_HUMAN (dh ic-2) (cytoplasmic dynein E.TQTPVMAQPKEDEEEDDDVV.A 2 2.997 0.127 P (97%) intermediate chain 2) (fragment). 10/2001 Q92630 homo sapiens (human). dual- specificity tyrosine-phosphorylation IPI:IPI00022521.1 SW:DYR2_HUMAN F.LKVIGK.G 1 1.888 0.098 P regulated kinase 2 (ec 2.7.1.-). (97%) 10/2001 Q15329 homo sapiens (human). SW:E2F5_HUMAN transcription factor e2f5 (e2f-5). T.DISSAGSISGDIIDEL.M 2 3.080 0.080 P 10/2001 P43003 homo sapiens (human). excitatory amino acid transporter 1 (sodium-dependent SW:EAA1_HUMAN A.VDWFLDRLR.T 2 2.632 0.088 O glutamate/aspartate transporter 1) (glial glutamate transporter) (glast-1). 10/2001 P43005 homo sapiens (human). excitatory amino acid transporter 3 (sodium-dependent SW:EAA3_HUMAN I.TISITATSASIGAAGVP.Q 2 2.722 0.150 P glutamate/aspartate transporter 3) (excitatory amino-acid carrier 1) (neuronal and epithelial glutamate t P48664 homo sapiens (human). excitatory amino acid transporter 4 IPI:IPI00010766.1 SW:EAA4_HUMAN (sodium-dependent L.EMEDMAVLGGQL.G 1 2.399 0.114 P (91%) glutamate/aspartate transporter). 10/2001 Q13011 homo sapiens (human). delta3,5-delta2,4-dienoyl-coa IPI:IPI00011416.1 SW:ECH1_HUMAN L.PKVIGNQSLVNELAFTAHKMMAD.E 2 2.921 0.091 A isomerase, mitochondrial precursor (96%) (ec 5.3.3.-). 10/2001 Supplementary Table 1 219 Q08426 homo sapiens (human). peroxisomal bifunctional enzyme (pbe) SW:ECHP_HUMA (pbfe) [includes: enoyl-coa hydratase IPI:IPI00216164.1 L.PEVTLGLLPGARGTQLLPR.L 2 2.645 0.113 A N (ec 4.2.1.17); 3,2-trans-enoyl-coa (95%) isomerase (ec 5.3.3.8); 3-hydroxyacyl- coa dehydr Q13201 homo sapiens (human). IPI:IPI00012269.1 SW:ECM_HUMAN endothelial cell multimerin precursor. I.KELEVKQTHLEGA.L 2 2.606 0.109 A, O (96%) 10/2001 V.TLDNQVTYVPGGKG.P 2 2.436 0.145 Q16610 homo sapiens (human). SW:ECM1_HUMA IPI:IPI00003351.1 extracellular matrix protein 1 precursor A.ASEGGFTATGQR.Q 2 3.714 0.387 O, P N (95%) (secretory component p85). 10/2001 A.SEGGFTATGQR.Q 2 3.261 0.424 K.ELPSLQHPNEQK.E 2 3.804 0.240 K.EVGPPLPQEAVPLQK.E 2 3.152 0.382 K.LLPAQLPAEK.E 2 2.424 0.202 K.LLPAQLPAEKEVGPPLPQEAVPLQK.E 3 3.937 0.320 R.DPALCCYL.S 1 2.070 0.104 R.NVALVSGDTENAK.G 2 2.685 0.147 R.QHVVYGPWNLPQSSYSHLTR.Q 2 4.184 0.378 3 3.732 0.253 P52732 homo sapiens (human). kinesin-related motor protein eg5 IPI:IPI00004972.1 SW:EG5_HUMAN (kinesin-like spindle protein hksp) I.FEKLTDNGTEFSVKVSLLEIYN.E 2 2.739 0.087 G (98%) (thyroid receptor interacting protein 5) (trip5). 5/2000 P17813 homo sapiens (human). SW:EGLN_HUMA IPI:IPI00219625.1 endoglin precursor (cd105 antigen). V.SLLSPSPEGDPR.F 2 2.535 0.111 G N (94%) 10/2001 Q9nzn3 homo sapiens (human). eh- IPI:IPI00021458.1 SW:EHD3_HUMAN D.EFALANHLIKVKLEGHELPNEL.P 2 2.686 0.112 G domain containing protein 3. 10/2001 (95%) P48553 homo sapiens (human). epilepsy holoprosencephaly SW:EHO1_HUMA IPI:IPI00010198.1 candidate-1 protein (ehoc-1) E.LAFVFEMLQQFEDALVQYDEL.D 2 3.074 0.124 G N (99%) (transmembrane protein 1) (gt334 protein). 10/2001 P09093 homo sapiens (human). IPI:IPI00012537.1 SW:EL3A_HUMAN elastase iiia precursor (ec 3.4.21.70) A.DIALIK.I 1 2.040 1.000 O, P (91%) (protease e). 10/2001 P19957 homo sapiens (human). elafin precursor (elastase-specific inhibitor) SW:ELAF_HUMAN V.FLIAGTLVLEAAVTGVPVKGQDTV.K 3 3.889 0.177 P (esi) (skin-derived antileukoproteinase) (skalp). 10/2001 P15502 homo sapiens (human). SW:ELS_HUMAN elastin precursor (tropoelastin). I.PTYGVGAGGFPGFGVGV.G 2 3.439 0.120 P 10/2001 Q9hc35 homo sapiens (human). echinoderm microtubule-associated protein-like 4 (emap-4) (restrictedly IPI:IPI00001466.2 SW:EML4_HUMAN Q.LSVMRYSIDGTFL.A 1 2.530 0.253 G overexpressed proliferation- (93%) associated protein) (ropp 120). 10/2001 Q9y227 homo sapiens (human). ectonucleoside triphosphate diphosphohydrolase 4 (ec 3.6.1.6) IPI:IPI00168612.1 SW:ENP4_HUMAN L.QVYDKEVQ.W 1 2.010 0.102 O (ntpdase4) (uridine-diphosphatase) (98%) (udpase) (lysosomal apyrase-like protein of 70 kda). 10/2001 P14625 homo sapiens (human). endoplasmin precursor (94 kda IPI:IPI00186178.1 SW:ENPL_HUMAN glucose-regulated protein) (grp94) G.YLLPDTK.A 1 1.879 0.122 P (95%) (gp96 homolog) (tumor rejection antigen 1). 10/2001 P29320 homo sapiens (human). ephrin type-a receptor 3 precursor (ec IPI:IPI00021273.1 SW:EPA3_HUMAN G.IILDYEVK.Y 1 1.835 0.107 P 2.7.1.112) (tyrosine-protein kinase (94%) receptor etk1) (hek) (hek4). 10/2001 P19235 homo sapiens (human). SW:EPOR_HUMA erythropoietin receptor precursor (epo- S.LILVVIL.V 1 2.017 1.000 A N r). 10/2001 P21860 homo sapiens (human). erbb- 3 receptor protein-tyrosine kinase SW:ERB3_HUMAN I.KRESGPGIAP.G 1 2.029 0.170 P precursor (ec 2.7.1.112) (tyrosine kinase-type cell surface receptor Supplementary Table 1 220 her3). 10/2001 P41161 homo sapiens (human). ets- R.YYYEKGIMQKVAGERYVYKFVCDPDAL SW:ERM_HUMAN related protein erm (ets translocation 3 3.771 0.101 P FSMAF.P variant 5). 10/2001 Q92817 homo sapiens (human). envoplakin (210 kda paraneoplastic SW:EVPL_HUMAN E.LLQQLEAEEKRLAVTERATGDLQRR.S 2 2.529 0.129 G pemphigus antigen) (p210) (210 kda cornified envelope precursor). 10/2001 Q03828 homo sapiens (human). SW:EVX2_HUMAN homeobox even-skipped homolog G.SESTVSSEISSAAESR.K 2 3.408 0.107 A protein 2 (evx-2). 10/2001 Q93063 homo sapiens (human). exostosin-2 (putative tumor IPI:IPI00217213.1 SW:EXT2_HUMAN F.GVSVSNTISREYNE.L 2 3.121 0.140 A, G suppressor protein ext2) (multiple (96%) exostoses protein 2). 7/1999 V.VRTAENKLSNRF.F 1 2.310 0.264 O00167 homo sapiens (human). eyes SW:EYA2_HUMAN L.LYGLGSVFPIENIYSATKTGKE.S 2 3.956 0.123 O absent homolog 2. 10/2001 P00488 homo sapiens (human). coagulation factor xiii a chain precursor (ec 2.3.2.13) (protein- IPI:IPI00219051.1 SW:F13A_HUMAN K.KDGTHVVENVDATHIGK.L 3 4.323 0.321 G, O, P glutamine gamma-glutamyltransferase (99%) a chain) (transglutaminase a chain). 10/2001 L.ETALMYGAKKPLNTEGVMK.S 2 2.598 0.144 R.AVPPNNSNAAEDDLPTVELQGVVPR.G 2 3.194 0.304 R.WDTNKVDHHTDKYENNK.L 3 3.689 0.254 Y.GVPPSAWTGSVDILLEYRSSENPVR.Y 2 2.615 0.175 P00748 homo sapiens (human). coagulation factor xii precursor (ec IPI:IPI00019581.1 SW:FA12_HUMAN R.LHEAFSPVSYQHDLALLR.L 2 5.875 0.604 O, P 3.4.21.38) (hageman factor) (haf). (91%) 10/2001 3 4.445 0.420 P12259 homo sapiens (human). IPI:IPI00022937.1 SW:FA5_HUMAN coagulation factor v precursor E.STPLANKPGK.Q 1 1.819 0.088 A, O (95%) (activated protein c cofactor). 10/2001 K.LSEGASYLDHTFPAEK.M 2 2.555 0.238 K.NKADKPLSIHPQGIR.Y 3 4.120 0.374 R.AEVDDVIQVR.F 2 3.261 0.268 R.ETDIEDSDDIPEDTTYK.K 2 2.732 0.359 R.HLSQDTGSPSGMRPWEDLPSQDTGS 3 3.553 0.288 PSR.M R.LNNGGSYNAWSVEK.L 2 2.332 0.266 R.MPMGLSTGIISDSQIK.A 2 4.090 0.326 R.SEAYNTFSER.R 2 3.100 0.301 R.SQHLDNFSNQIGK.H 2 3.977 0.385 P00740 homo sapiens (human). SW:FA9_HUMAN coagulation factor ix precursor (ec K.ITVVAGEHNIEETEHTEQKR.N 3 3.503 0.261 O, P 3.4.21.22) (christmas factor). 10/2001 R.IIPHHNYNAAINK.Y 2 3.048 0.240 Q92636 homo sapiens (human). protein fan (factor associated with n- IPI:IPI00022528.1 SW:FAN_HUMAN smase activation) (factor associated C.FVWDGNSVLSGSQSGEL.L 2 2.640 0.090 O (99%) with neutral-sphingomyelinase activation). 10/2001 Q14517 homo sapiens (human). cadherin-related tumor suppressor A.TDGENFATPLYINITVAASHKLVNLQCE IPI:IPI00031411.1 SW:FATH_HUMAN 3 4.121 0.261 A, G, O, P homolog precursor (fat protein ETG.V (97%) homolog). 10/2001 E.YDLMVKATDK.G 1 1.812 0.103 F.VCQCRGLYTGQRCQLSPYCK.D 2 2.203 0.101 K.VVASDHGEKIQLSSTAIVDVTVTDVNDS 2 2.590 0.194 PPRF.T 3 3.752 0.136 Q.EFPNYEVIDEQTPLYSADP.N 2 4.214 0.141 P23142 homo sapiens (human). IPI:IPI00220011.1 SW:FBL1_HUMAN R.EFTRPEEIIFLR.A 2 3.163 0.129 P fibulin-1 precursor. 10/2001 (97%) P35555 homo sapiens (human). I.CGPGTCYNTVGNYTCICPPDYMQVNG IPI:IPI00215915.1 SW:FBN1_HUMAN 3 3.811 0.140 A, G, O fibrillin 1 precursor. 10/2001 GNNCMD.M (97%) K.TNDDQTMCL.D 1 2.121 0.092 R.LGIMRRGRLLEIALGFTVLLASY.T 2 2.558 0.167 V.EYLYPSR.E 1 1.807 0.106 Supplementary Table 1 221 SW:FBW3_HUMA Q9ukb7 homo sapiens (human). f- F.SPLKIWDLNSGQLM.T 1 2.107 0.161 A N box/wd-repeat protein 3. 10/2001 V.AIRPLLSSFVTGT.A 1 2.168 0.124 Q9uk22 homo sapiens (human). f-box SW:FBX2_HUMAN R.LVCLRWKELVDGAPLWLL.K 2 2.987 0.160 G only protein 2. 10/2001 O75072 homo sapiens (human). SW:FCMD_HUMA fukutin precursor (fukuyama-type IPI:IPI00023976.2 K.VEDSLELSF.Q 1 2.164 0.095 A N congenital muscular dystrophy (96%) protein). 10/2001 O75636 homo sapiens (human). ficolin 3 precursor (collagen/fibrinogen domain-containing protein 3) SW:FCN3_HUMAN K.YGIDWASGR.G 2 2.757 0.237 O, P (collagen/fibrinogen domain- containing lectin 3 p35) (hakata antigen). 10/2001 R.LLGEVDHYQLALGK.F 2 4.067 0.409 R.RQDGSVDFFR.S 2 3.246 0.261 R.TFAHYATFR.L 2 2.924 0.377 P16591 homo sapiens (human). proto- IPI:IPI00029263.1 SW:FER_HUMAN oncogene tyrosine-protein kinase fer R.DLAARNCLVGENNVLKISDFGMSR.Q 2 2.326 0.109 G, P (98%) (ec 2.7.1.112) (p94-fer) (c-fer). 5/2000 T.EEIVNVHKEIQMSVEQIDPSTEYNNFID 3 3.858 0.260 VHR.T Q92912 homo sapiens (human), and mus musculus (mouse). fibroblast SW:FGFC_HUMA growth factor-12 (fgf-12) (fibroblast V.AMNGEGYLYSSDVFTPECK.F 2 2.593 0.107 O N growth factor homologous factor 1) (fhf-1) (myocyte-activating factor). 10/2001 Q9y613 homo sapiens (human). SW:FHOS_HUMA fh1/fh2 domains-containing protein IPI:IPI00001730.1 G.RAETLAGAMPNEAGGHPDARQL.W 2 3.399 0.208 A, P N (formin homolog overexpressed in (93%) spleen) (fhos). 10/2001 L.PTRAPRLSIGDLDFSDLGEDEDQDMLN 2 2.269 0.106 VESVEAGK.D T.TGAPPWANLVSILEEKNGADPELLVYT 2 2.266 0.129 VTLINK.T Q03591 homo sapiens (human). complement factor h-related protein 1 G.DTVQIICNTGYRLQNNENNISCVERGW IPI:IPI00011264.1 SW:FHR1_HUMAN 3 3.623 0.161 A, P precursor (fhr-1) (h factor-like protein STPPK.C (95%) 1) (h-factor like 1) (h36). 10/2001 K.INHGILYDEEK.Y 2 3.956 0.342 Q92496 homo sapiens (human). SW:FHR4_HUMAN complement factor h-related protein 4 V.SCANGQEVKPCDFPEIQHGGLY.Y 2 3.806 0.181 A precursor (fhr-4). 10/2001 P02671 homo sapiens (human). SW:FIBA_HUMAN fibrinogen alpha/alpha-e chain A.AFFDTASTGK.T 1 2.004 0.333 A, G, O, P precursor. 10/2001 A.DEAGSEADHEGTHSTK.R 2 4.441 0.501 A.DEAGSEADHEGTHSTKR.G 2 2.667 0.248 A.DSGEGDFLAEGGGVR.G 1 2.553 0.323 2 5.425 0.438 A.DSGEGDFLAEGGGVRGPR.V 1 2.020 0.147 A.GSEADHEGTHSTK.R 2 3.807 0.345 A.GSEADHEGTHSTKR.G 2 2.765 0.265 A.GSWNSGSSGPGSTGNR.N 2 4.084 0.356 A.LTDMPQMR.M 2 2.620 0.238 D.CPEAMDLGTLSGIGTLDGFR.H 2 2.502 0.358 D.EAGSEADHEGTHSTK.R 2 2.276 0.120 D.EAGSEADHEGTHSTKR.G 2 2.495 0.269 D.EVNQDFTNR.I 2 2.390 0.221 D.SGEGDFLAEGGGVR.G 2 4.272 0.352 D.SGEGDFLAEGGGVRGPR.V 2 2.575 0.200 D.SHSLTTNIMEILR.G 2 4.481 0.450 D.SPGSGNARPNNPDWGTFEEVSGNVS 2 2.915 0.263 PGTR.R E.AGSEADHEGTHSTK.R 2 2.745 0.334 E.AGSEADHEGTHSTKR.G 2 3.134 0.368 E.DGSDCPEAMDLGTLSGIGTLDGFR.H 2 3.396 0.361 E.GDFLAEGGGVR.G 1 2.013 0.157 E.LERPGGNEITR.G 2 3.059 0.232
Supplementary Table 1 222 E.SGIFTNTK.E 1 1.995 0.129 E.SGSFRPDSPGSGNAR.P 2 2.900 0.197 E.SSSHHPGIAEFPSR.G 2 3.525 0.360 3 4.606 0.296 E.SSVSGSTGQWHSESGSFRPDSPGSG 3 3.992 0.354 NAR.P F.EEVSGNVSPGTR.R 2 2.456 0.209 F.FSPMLGEFVSETESR.G 2 3.802 0.422 F.LAEGGGVRGPR.V 2 2.261 0.125 F.PGFFSPMLGEFVSETESR.G 2 5.371 0.366 F.SSANNRDNTYNR.V 2 2.204 0.134 F.TSSTSYNRGDSTFESK.S 2 2.525 0.212 G.EGDFLAEGGGVR.G 2 2.612 0.280 G.GSTSYGTGSETESPR.N 2 2.308 0.306 G.SESGIFTNTK.E 1 2.476 0.273 2 3.069 0.163 G.SFRPDSPGSGNAR.P 2 2.873 0.288 G.SSGTGSTGNQNPGSPR.P 2 2.889 0.273 G.STGTWNPGSSER.G 2 2.835 0.155 G.STSYGTGSETESPR.N 2 3.900 0.502 G.STSYGTGSETESPRNPSSAGSWNSGS 3 4.576 0.405 SGPGSTGNR.N G.SWNSGSSGPGSTGNR.N 2 3.857 0.363 G.SWNSGSSGTGSTGNQNPGSPRPGST 3 3.652 0.278 GTWNPGSSER.G H.PGIAEFPSR.G 1 2.228 0.301 H.RHPDEAAFFDTASTGK.T 2 5.778 0.562 3 5.195 0.383 H.SESGSFRPDSPGSGNAR.P 2 2.333 0.137 H.SLTTNIMEILR.G 2 3.881 0.222 I.GPDGHKEVTK.E 1 1.868 0.162 K.ALTDMPQ.M 1 1.829 0.099 K.ALTDMPQM.R 1 2.139 0.250 K.ALTDMPQMR.M 1 2.244 0.087 2 2.647 0.190 K.DSHSLTTNIMEILR.G 1 3.788 0.416 2 4.694 0.442 3 3.580 0.118 K.DYEDQQKQLEQVIAK.D 2 3.939 0.316 3 4.119 0.214 K.EKVTSGSTTTT.R 2 2.570 0.195 K.EKVTSGSTTTTR.R 2 3.293 0.269 K.ESSSHHPGIAEFPS.R 1 2.999 0.333 2 3.078 0.261 K.ESSSHHPGIAEFPSR.G 1 3.726 0.440 2 3.724 0.356 3 3.673 0.389 K.ESSSHHPGIAEFPSRG.K 2 3.409 0.441 K.ESSSHHPGIAEFPSRGK.S 2 2.776 0.277 3 4.174 0.250 K.GLIDEVNQD.F 1 1.910 0.179 K.GLIDEVNQDFTN.R 2 2.829 0.316 K.GLIDEVNQDFTNR.I 1 2.526 0.255 2 4.488 0.306 K.GLIDEVNQDFTNRINK.L 2 4.483 0.281 K.LKNSLFEYQK.N 1 2.881 0.212 2 3.766 0.321 K.LKNSLFEYQKNNKDSHSLTTNIMEILR. 3 3.635 0.088 G K.LVTSKGDKELR.T 2 3.499 0.269 K.MADEAGSEADHEGTH.S 2 4.345 0.506 K.MADEAGSEADHEGTHS.T 2 3.927 0.440 K.MADEAGSEADHEGTHST.K 2 3.922 0.271 K.MADEAGSEADHEGTHSTK.R 1 3.782 0.409 2 5.325 0.513 Supplementary Table 1 223 3 3.868 0.292 K.MADEAGSEADHEGTHSTKR.G 2 5.265 0.589 3 3.744 0.348 K.MKPVPDLVPGNF.K 2 2.664 0.260 K.MKPVPDLVPGNFK.S 1 3.107 0.382 2 3.486 0.357 K.NNKDSHSLTTNIMEILR.G 2 5.232 0.390 3 4.869 0.344 K.NSLFEYQK.N 1 2.417 0.115 2 2.552 0.233 K.NSLFEYQKNNKDSHSLTTNIMEILR.G 3 4.994 0.437 K.PGSSGPGSTGSWNSGSSGTGSTGNQ 2 3.901 0.420 NPGSPR.P K.PVPDLVPGNFK.S 1 2.265 0.272 K.QFTSSTSYNR.G 1 2.039 0.112 2 2.918 0.237 K.QFTSSTSYNRGDSTFES.K 2 4.161 0.506 K.QFTSSTSYNRGDSTFESK.S 2 3.950 0.301 K.QFTSSTSYNRGDSTFESKS.Y 2 2.923 0.256 K.QLEQVIAK.D 2 2.398 0.154 K.RLEVDIDIK.I 2 2.764 0.175 K.SQLQKVPPEWK.A 2 3.953 0.245 K.SYKMADEAGSEADHEGTHSTK.R 3 3.772 0.296 K.TFPGFFSPMLGEFVSETES.R 2 3.174 0.346 K.TFPGFFSPMLGEFVSETESR.G 2 4.524 0.444 3 4.749 0.363 K.TVIGPDGHK.E 2 2.489 0.118 K.TVIGPDGHKEVTK.E 1 2.368 0.180 2 4.354 0.361 K.TVTKTVIGPDGHKEVTK.E 3 4.078 0.354 K.VIEKVQHIQLL.Q 2 2.831 0.156 K.VIEKVQHIQLLQK.N 1 2.657 0.222 2 4.465 0.335 3 3.589 0.292 K.VIEKVQHIQLLQKNVR.A 2 2.334 0.214 3 4.578 0.346 K.VQHIQLLQK.N 1 2.815 0.190 2 3.112 0.112 K.VQHIQLLQKNVR.A 2 3.371 0.297 K.VTSGSTTTTR.R 2 2.838 0.214 L.GEFVSETESR.G 2 3.398 0.279 M.ADEAGSEADHEGTHSTK.R 2 3.911 0.434 M.DLGTLSGIGTLDGFR.H 1 2.413 0.159 2 4.855 0.489 M.ELERPGGNEITR.G 1 2.062 0.255 2 2.924 0.139 M.KPVPDLVPGNF.K 2 2.522 0.422 M.KPVPDLVPGNFK.S 1 2.878 0.196 2 4.139 0.383 M.LGEFVSETESR.G 1 2.371 0.327 2 3.533 0.258 N.ARPNNPDWGTFEEVSGNVSPGTR.R 2 4.561 0.400 N.IMEILR.G 1 1.886 0.153 N.NPDWGTFEEVSGNVSPGTR.R 2 6.517 0.498 N.PDWGTFEEVSGNVSPGTR.R 2 5.594 0.533 N.PGSPRPGSTGTWNPGSSER.G 2 4.311 0.310 3 4.018 0.301 N.PGSSGTGGTATWKPGSSGP.G 2 3.037 0.362 N.PGSSGTGGTATWKPGSSGPGSTGSW 3 5.222 0.429 NSGSSGTGSTGNQNPGSPR.P N.PSSAGSWNSGSSGPGSTGNR.N 2 5.172 0.525 N.SGSSGTGSTGNQNPGSPR.P 2 4.789 0.440 N.SGSSGTGSTGNQNPGSPRPGSTGTW 2 2.557 0.124 NPGSSER.G
Supplementary Table 1 224 3 3.983 0.287 N.SLFEYQKNNKDSHSLTTNIMEILR.G 3 4.024 0.213 N.TKESSSHHPGIAEFPSR.G 3 3.612 0.248 P.DEAAFFDTA.S 1 2.023 0.249 P.DEAAFFDTASTGK.T 1 3.186 0.374 2 3.829 0.375 P.GFFSPMLGEFVSETESR.G 2 3.570 0.460 P.GSSGTGGTATWKPG.S 2 3.042 0.317 P.GSSGTGGTATWKPGSSGP.G 2 3.607 0.390 P.GSSGTGGTATWKPGSSGPG.S 2 3.810 0.398 P.GSSGTGGTATWKPGSSGPGSTG.S 2 3.953 0.399 P.GSSGTGGTATWKPGSSGPGSTGS.W 2 3.500 0.402 P.GSSGTGGTATWKPGSSGPGSTGSWN. 2 4.741 0.419 S P.GSSGTGGTATWKPGSSGPGSTGSWN 3 6.551 0.484 SGSSGTGSTGNQNPGSPR.P P.SSAGSWNSGSSGPGSTGNR.N 2 5.251 0.455 P.SSAGSWNSGSSGPGSTGNRN.P 2 3.337 0.408 P.VPDLVPGNFK.S 1 2.514 0.165 2 2.659 0.133 Q.FTSSTSYNR.G 2 2.621 0.273 R.AQLVDMK.R 1 2.044 0.194 R.DRQHLPLIK.M 2 2.792 0.109 R.EVDLKDYEDQQK.Q 1 3.343 0.342 2 4.156 0.301 R.EVDLKDYEDQQKQLEQVIA.K 2 3.705 0.390 R.EVDLKDYEDQQKQLEQVIAK.D 2 5.153 0.465 3 5.434 0.367 R.EVDLKDYEDQQKQLEQVIAKDLLPSR. 3 5.710 0.437 D R.EVDLKDYEDQQKQLEQVIAKDLLPSRD 3 4.153 0.309 R.Q R.EYHTEKLVTSKGDKELR.T 3 3.897 0.355 R.GDFSSANNR.D 2 3.099 0.360 R.GDFSSANNRDNTYN.R 2 3.343 0.437 R.GDFSSANNRDNTYNR.V 1 2.040 0.187 2 3.090 0.247 R.GDSTFESK.S 2 2.236 0.188 R.GGSTSYGTGSETESPR.N 1 2.365 0.264 2 4.260 0.506 R.GGSTSYGTGSETESPRN.P 2 4.319 0.509 R.GGSTSYGTGSETESPRNPS.S 2 5.304 0.469 R.GGSTSYGTGSETESPRNPSS.A 2 3.985 0.481 R.GGSTSYGTGSETESPRNPSSA.G 2 4.313 0.325 R.GGSTSYGTGSETESPRNPSSAG.S 2 4.829 0.499 R.GGSTSYGTGSETESPRNPSSAGS.W 2 3.915 0.513 R.GGSTSYGTGSETESPRNPSSAGSWN. 2 4.951 0.457 S R.GGSTSYGTGSETESPRNPSSAGSWNS 2 3.621 0.444 G.S R.GGSTSYGTGSETESPRNPSSAGSWNS 2 3.549 0.259 GSSGP.G R.GGSTSYGTGSETESPRNPSSAGSWNS 3 4.743 0.380 GSSGPGSTGN.R R.GGSTSYGTGSETESPRNPSSAGSWNS 2 3.201 0.357 GSSGPGSTGNR.N 3 5.860 0.338 R.GGSTSYGTGSETESPRNPSSAGSWNS 3 4.555 0.330 GSSGPGSTGNRN.P R.GSAGHWTSESSVSGS.T 2 2.924 0.298 R.GSAGHWTSESSVSGSTGQ.W 2 3.043 0.272 R.GSAGHWTSESSVSGSTGQWHSESG.S 2 6.071 0.467 R.GSAGHWTSESSVSGSTGQWHSESGS 3 4.450 0.396 FR.P R.GSAGHWTSESSVSGSTGQWHSESGS 3 5.960 0.475 FRPDSPGSGN.A R.GSAGHWTSESSVSGSTGQWHSESGS 3 4.545 0.393 FRPDSPGSGNAR.P Supplementary Table 1 225 R.GSAGHWTSESSVSGSTGQWHSESGS 3 3.673 0.268 FRPDSPGSGNARPN.N R.GSESGIFTNTK.E 1 2.680 0.195 2 3.807 0.437 R.GSESGIFTNTKESSSHHPGIAEFPSR.G 2 3.041 0.332 3 4.278 0.348 R.HPDEAAFFDTA.S 1 2.300 0.246 R.HPDEAAFFDTASTGK.T 1 3.792 0.410 2 4.335 0.456 3 4.292 0.316 R.HQSACKDSDWPFCSDEDWNYK.C 2 2.753 0.124 R.HQSACKDSDWPFCSDEDWNYKCPSG 3 3.615 0.085 CR.M R.HRHPDEAAFFDTA.S 2 2.826 0.419 R.HRHPDEAAFFDTASTG.K 2 3.528 0.391 R.HRHPDEAAFFDTASTGK.T 1 2.777 0.303 2 5.988 0.567 3 5.150 0.388 R.IVCLVLSVVGTAWTADSGEGDF.L 2 3.354 0.120 R.KVIEKVQHIQLL.Q 2 2.510 0.121 R.KVIEKVQHIQLLQK.N 2 4.672 0.362 3 3.973 0.303 R.MELERPGGNEIT.R 1 2.421 0.257 2 4.156 0.266 R.MELERPGGNEITR.G 1 2.575 0.163 2 3.599 0.312 R.MKGLIDEVNQDFTNR.I 2 4.329 0.445 3 4.322 0.328 R.MKGLIDEVNQDFTNRINK.L 2 2.730 0.243 3 4.060 0.329 R.NPGSSGTGGTAT.W 1 2.106 0.122 R.NPGSSGTGGTATWK.P 1 3.487 0.415 2 3.555 0.401 R.NPGSSGTGGTATWKPG.S 2 4.058 0.388 R.NPGSSGTGGTATWKPGS.S 2 4.351 0.474 R.NPGSSGTGGTATWKPGSSGP.G 2 4.525 0.384 R.NPGSSGTGGTATWKPGSSGPG.S 2 4.551 0.452 R.NPGSSGTGGTATWKPGSSGPGSTG.S 2 3.673 0.354 R.NPGSSGTGGTATWKPGSSGPGSTGS 2 5.387 0.406 WN.S R.NPGSSGTGGTATWKPGSSGPGSTGS 2 3.844 0.297 WNSGS.S R.NPGSSGTGGTATWKPGSSGPGSTGS 2 2.912 0.302 WNSGSSGTG.S R.NPGSSGTGGTATWKPGSSGPGSTGS 2 2.735 0.179 WNSGSSGTGSTGN.Q 3 4.653 0.384 R.NPGSSGTGGTATWKPGSSGPGSTGS 3 5.912 0.482 WNSGSSGTGSTGNQN.P R.NPGSSGTGGTATWKPGSSGPGSTGS 3 3.783 0.221 WNSGSSGTGSTGNQNPG.S R.NPGSSGTGGTATWKPGSSGPGSTGS 3 5.917 0.468 WNSGSSGTGSTGNQNPGSPR.P R.NPGSSGTGGTATWKPGSSGPGSTGS 3 4.468 0.344 WNSGSSGTGSTGNQNPGSPRPG.S R.NPSSAGSWN.S 1 2.175 0.220 R.NPSSAGSWNSGSSGPGSTGN.R 2 2.870 0.292 R.NPSSAGSWNSGSSGPGSTGNR.N 1 2.172 0.157 2 5.750 0.564 3 5.966 0.471 R.NPSSAGSWNSGSSGPGSTGNRN.P 2 5.622 0.536 R.NPSSAGSWNSGSSGPGSTGNRNPGS 3 4.024 0.157 SGTGGTATWKPGSSGP.G R.PDSPGSGNARPNNPDWGTFEEVSGN 3 4.091 0.334 VSPGTR.R R.PGGNEITR.G 1 2.118 0.118 2 2.959 0.251
Supplementary Table 1 226 R.PGSTGTWNPGSSER.G 1 2.748 0.373 2 4.343 0.444 R.PNNPDWGTFEEVSGNVSPGTR.R 2 6.208 0.575 3 3.660 0.237 S.AGSWNSGSSGPGSTGNR.N 2 3.551 0.450 S.ESSVSGSTGQWHSESGSFRPDSPGS 3 4.039 0.240 GNAR.P S.GEGDFLAEGGGVR.G 2 4.466 0.469 S.GSSGTGSTGNQNPGSPR.P 2 2.770 0.415 S.SAGSWNSGSSGPGSTGNR.N 2 4.392 0.384 S.SGTGGTATWKPGSSGPGSTGSWNSG 3 4.533 0.416 SSGTGSTGNQNPGSPR.P S.SGTGSTGNQNPGSPR.P 2 4.200 0.363 S.SHHPGIAEFPSR.G 2 2.923 0.415 S.SSHHPGIAEFPSR.G 2 3.450 0.301 3 4.552 0.221 S.SVSGSTGQWHSESGSFRPDSPGSGN 3 4.039 0.377 AR.P S.TGNRNPGSSGTGGTATWKPGSSGPG 3 3.929 0.263 STGSWNSGSSGTGSTGNQNPGSPR.P S.TSYGTGSETESPR.N 2 3.154 0.465 S.WNSGSSGPGSTGNR.N 2 3.334 0.275 S.WNSGSSGTGSTGNQNPGSPR.P 2 4.780 0.544 S.YGTGSETESPR.N 2 2.497 0.401 T.ADSGEGDFLAEGGGV.R 2 4.321 0.412 T.ADSGEGDFLAEGGGVR.G 1 2.672 0.346 2 5.266 0.434 T.ADSGEGDFLAEGGGVRGPR.V 1 1.862 0.106 2 2.332 0.103 T.GSWNSGSSGTGSTGNQNPGSPR.P 2 2.730 0.327 T.SEDGSDCPEAMDLGTLSGIGTLDGFR. 2 2.921 0.223 H T.SYGTGSETESPR.N 2 3.034 0.430 T.SYNRGDSTFESK.S 2 2.206 0.103 T.WKPGSSGPGSTGSWN.S 2 3.039 0.285 T.WKPGSSGPGSTGSWNSGSSGTGSTG 2 3.364 0.363 NQNPGSPR.P 3 5.101 0.473 V.DLKDYEDQQK.Q 2 2.419 0.298 V.IGPDGHKEVTK.E 2 2.605 0.323 V.TSKGDKELR.T 1 1.921 0.144 W.NSGSSGTGSTGNQNPGSPR.P 2 2.444 0.310 Y.NRGDSTFESK.S 2 2.568 0.258 P02675 homo sapiens (human). IPI:IPI00021886.1 SW:FIBB_HUMAN fibrinogen beta chain precursor. A.HYGGFTVQNEANK.Y 1 3.634 0.282 A, G, O, P (98%) 10/2001 2 5.005 0.316 3 3.745 0.276 A.PSLRPAPPPISGGGYR.A 2 3.449 0.380 D.NENVVNEYSSELEK.H 2 3.814 0.439 D.NENVVNEYSSELEKHQLYIDETVNSNIP 3 5.036 0.341 TNLR.V E.APSLRPAPPPISGGGYR.A 2 2.763 0.183 G.VNDNEEGFFSA.R 2 2.999 0.314 G.VNDNEEGFFSAR.G 1 2.031 0.112 2 4.230 0.324 H.YGGFTVQNEANK.Y 2 4.392 0.433 I.RPFFPQQ.- 2 2.406 0.273 K.AHYGGFTVQNEA.N 1 3.133 0.324 2 2.963 0.214 K.AHYGGFTVQNEAN.K 1 2.341 0.287 2 3.347 0.264 K.AHYGGFTVQNEANK.Y 1 4.270 0.395 2 4.983 0.436 3 4.271 0.268 K.AHYGGFTVQNEANKYQISVNK.Y 2 6.297 0.443 Supplementary Table 1 227 3 5.641 0.443 K.AHYGGFTVQNEANKYQISVNKYR.G 3 5.426 0.452 K.DNENVVNEYSSELEK.H 1 3.617 0.280 2 5.303 0.296 K.DNENVVNEYSSELEKHQLYIDETVNSNI 3 6.330 0.430 PTNLR.V K.EDGGGWWYNR.C 1 2.726 0.205 2 3.673 0.330 K.GGETSEMYLIQPD.S 2 2.700 0.085 K.GGETSEMYLIQPDSSVK.P 2 3.582 0.181 K.GGETSEMYLIQPDSSVKPY.R 2 3.240 0.335 K.GGETSEMYLIQPDSSVKPYR.V 2 5.326 0.416 3 5.137 0.326 K.HGTDDGVVWMN.W 1 1.967 0.171 K.HGTDDGVVWMNWK.G 1 4.669 0.448 2 5.668 0.488 K.HQLYIDETVNS.N 2 3.632 0.371 K.HQLYIDETVNSNIPTNLR.V 2 5.752 0.489 3 4.582 0.273 K.KREEAPSLRPAPPPISGGGY.R 2 3.260 0.333 K.KREEAPSLRPAPPPISGGGYR.A 2 3.056 0.185 3 5.317 0.431 K.QGFGNVATNTDGK.N 1 2.583 0.323 2 3.778 0.380 K.QVKDNENVVNEYSSELEK.H 2 3.661 0.353 3 3.755 0.211 K.REEAPSLR.P 2 3.121 0.169 K.REEAPSLRPAPPPISGGGY.R 2 4.359 0.363 3 3.515 0.402 K.REEAPSLRPAPPPISGGGYR.A 2 3.051 0.253 3 5.681 0.506 K.VKAHYGGFTVQNEANK.Y 2 3.991 0.376 3 3.890 0.221 K.YQISVNK.Y 1 2.700 0.221 2 2.360 0.172 K.YQISVNKYR.G 2 2.911 0.300 L.YIDETVNSNIPTNLR.V 2 3.857 0.460 M.GPTELLIEMEDWK.G 2 4.635 0.352 M.YLIQPDSSVKPYR.V 2 3.088 0.196 N.DNEEGFFSAR.G 2 3.405 0.354 N.EANKYQISVNK.Y 2 2.601 0.290 N.ENVVNEYSSELEK.H 2 2.430 0.156 N.GMFFSTYDR.D 2 2.610 0.370 N.KYQISVNK.Y 2 2.673 0.229 Q.GFGNVATNTDGK.N 2 3.098 0.291 Q.GVNDNEEGFFSAR.G 2 3.791 0.361 Q.NEANKYQISVNK.Y 2 2.705 0.269 Q.PDSSVKPYR.V 1 1.901 0.180 R.DNDGWLTSDPR.K 2 4.265 0.318 R.EEAPSLRPAPPPISGGGY.R 2 3.902 0.476 R.EEAPSLRPAPPPISGGGYR.A 2 3.246 0.305 3 4.200 0.464 R.GHRPLDK.K 2 2.469 0.227 R.GHRPLDKK.R 2 2.302 0.275 R.GTAGNALMDGASQ.L 2 3.208 0.216 R.GTAGNALMDGASQL.M 2 3.365 0.420 R.KGGETSEMYLIQPD.S 2 3.153 0.163 R.KGGETSEMYLIQPDSSVK.P 2 4.251 0.432 R.KGGETSEMYLIQPDSSVKPYR.V 2 6.107 0.420 3 5.699 0.294 R.KWDPYK.Q 2 2.474 0.102 R.MGPTELLIEMEDWK.G 1 4.182 0.383 2 5.251 0.414 3 4.385 0.286 Supplementary Table 1 228 R.MGPTELLIEMEDWKGD.K 2 3.450 0.265 R.MGPTELLIEMEDWKGDK.V 2 5.813 0.509 3 3.617 0.208 R.MGPTELLIEMEDWKGDKVK.A 2 4.475 0.256 3 4.580 0.384 R.NSVDELNNNVEAVSQTSSSSFQYMYL 2 4.903 0.444 LK.D 3 6.850 0.482 R.NSVDELNNNVEAVSQTSSSSFQYMYL 3 5.560 0.468 LKDLWQKR.Q R.PIRNSVDELNNNVEAVSQTSSSSFQYM 3 3.730 0.169 YLLK.D R.QDGSVDFGR.K 1 1.838 0.249 2 2.537 0.331 R.QDGSVDFGRK.W 2 2.790 0.259 R.SILENLR.S 1 1.809 0.125 R.TMTIHNGMFFSTYDR.D 2 4.042 0.420 R.TMTIHNGMFFSTYDRDNDGWLTSDPR. 3 3.906 0.303 K R.TMTIHNGMFFSTYDRDNDGWLTSDPR 3 4.129 0.200 K.Q R.TPCTVSCNIPVVSGK.E 2 3.180 0.124 R.VLRSILENLR.S 2 3.855 0.203 R.YYWGGQYTWDMAK.H 1 3.752 0.442 2 4.784 0.390 S.KEDGGGWWYNR.C 2 2.348 0.187 S.LRPAPPPISGGGYR.A 2 3.724 0.465 V.ATNTDGK.N 1 2.115 0.130 V.NDNEEGFFSAR.G 2 3.500 0.320 W.GGQYTWDMAK.H 2 2.736 0.287 Y.LIQPDSSVKPYR.V 2 2.824 0.288 Y.LIQPDSSVKPYRVYCDMNTENGGWTVI 3 3.620 0.283 QNR.Q Y.WGGQYTWDMAK.H 2 3.820 0.389 Y.YWGGQYTWDMAK.H 2 4.000 0.168 P02679 homo sapiens (human). IPI:IPI00021891.3 SW:FIBG_HUMAN fibrinogen gamma chain precursor. -.TADYAMFK.V 1 1.923 0.194 A, G, O, P (95%) 10/2001 A.SILTHDSSIR.Y 2 2.368 0.240 A.STPNGYDNGIIWATWK.T 2 3.044 0.333 E.GQQHHLGGAK.Q 2 3.468 0.092 F.AGGDAGDAFDGFDFGDDPSDK.F 2 4.958 0.555 F.AGGDAGDAFDGFDFGDDPSDKF.F 2 2.417 0.206 H.LISTQSAIPYALR.V 2 3.491 0.326 I.GEGQQHHLGGAK.Q 1 2.682 0.262 2 3.786 0.277 I.HLISTQSAIPYALR.V 1 3.434 0.300 2 4.898 0.419 I.MLEEIMK.Y 1 2.206 0.088 I.MLEEIMKYEASILTHDSSIR.Y 2 5.357 0.569 3 6.598 0.444 I.PFNRLTIGEGQQHHLGGAK.Q 3 5.633 0.355 I.QLTYNPDESSKPNMIDAATLK.S 2 3.723 0.382 K.AIQLTYNPDES.S 1 2.107 0.180 K.AIQLTYNPDESSK.P 2 3.753 0.408 K.AIQLTYNPDESSKPN.M 1 3.248 0.319 2 4.595 0.386 K.AIQLTYNPDESSKPNMIDAA.T 2 4.910 0.460 K.AIQLTYNPDESSKPNMIDAAT.L 2 3.417 0.340 K.AIQLTYNPDESSKPNMIDAATLK.S 2 4.547 0.378 3 3.844 0.274 K.ASTPNGYDNGIIWATWK.T 1 2.599 0.122 2 4.365 0.378 K.DTVQIHDITGK.D 2 3.844 0.284 K.EGFGHLSPTGTTEF.W 2 2.871 0.296 K.EGFGHLSPTGTTEFWLGNEK.I 2 6.257 0.513 Supplementary Table 1 229 3 5.124 0.313 K.EGFGHLSPTGTTEFWLGNEKIHLISTQS 3 5.525 0.426 AIPYALR.V K.IHLISTQS.A 1 2.089 0.147 2 2.518 0.201 K.IHLISTQSAIPY.A 2 2.763 0.171 K.IHLISTQSAIPYAL.R 2 2.617 0.164 K.IHLISTQSAIPYALR.V 1 4.150 0.374 2 5.189 0.402 3 3.652 0.112 K.IHLISTQSAIPYALRVELEDWNGR.T 3 4.783 0.340 K.IIPFNRLTIGEGQQHHLGGAK.Q 2 4.088 0.334 3 3.775 0.384 K.IVNLKEK.V 1 1.970 0.082 2 2.307 0.108 K.KNWIQYK.E 2 2.717 0.085 K.NWIQYKEGFGHLSPTGTTEFWLGNEK.I 3 5.980 0.420 K.QSGLYFIKPLK.A 1 2.162 0.131 2 3.806 0.335 K.RLDGSVDFK.K 1 1.982 0.198 2 3.118 0.253 K.RLDGSVDFKK.N 1 2.032 0.082 2 3.276 0.255 K.TRWYSMK.K 2 2.551 0.260 K.TTMKIIPFNRLTIGEGQQHHLGGAK.Q 3 3.692 0.322 K.VAQLEAQCQEPCKDTVQIHDITGK.D 2 4.008 0.238 3 5.350 0.349 K.VDKDLQSLED.I 2 2.837 0.127 K.VGPEADKYR.L 1 2.466 0.288 2 3.207 0.298 K.YEASILTHDSSIR.Y 1 2.540 0.310 2 4.053 0.408 L.DGSVDFKK.N 1 2.338 0.210 2 2.722 0.122 L.TIGEGQQHHLGGAK.Q 1 2.992 0.278 2 3.463 0.167 L.TYNPDESSKPN.M 2 2.920 0.380 L.TYNPDESSKPNMIDAATLK.S 2 3.831 0.461 N.GVYYQGGTYSK.A 2 2.623 0.271 N.PDESSKPNMIDAATLK.S 2 4.402 0.279 3 4.434 0.323 P.NGYDNGIIWATWK.T 2 3.298 0.193 Q.LTYNPDESSKPNMIDAATLK.S 2 4.289 0.377 R.FGSYCPTTCGIADFLSTYQTK.V 2 4.789 0.322 R.LDGSVDFK.K 1 2.288 0.191 2 2.903 0.347 R.LDGSVDFKK.N 2 3.014 0.247 R.LTIGEGQQHHLG.G 2 2.704 0.215 R.LTIGEGQQHHLGGA.K 2 3.171 0.349 R.LTIGEGQQHHLGGAK.Q 1 3.890 0.407 2 4.612 0.432 R.LTYAYFAGGDAGDAFDGFDFGDD.P 2 3.269 0.438 R.LTYAYFAGGDAGDAFDGFDFGDDPSD 2 5.815 0.637 K.F R.LTYAYFAGGDAGDAFDGFDFGDDPSD 3 4.542 0.320 KFFTSHN.G R.TSTADYAMFK.V 1 2.464 0.296 2 2.822 0.343 R.VELEDWNGR.T 1 2.169 0.193 2 3.184 0.110 R.YLQEIYNSNNQK.I 1 3.255 0.213 2 5.164 0.235 R.YLQEIYNSNNQKIVNLK.E 2 5.239 0.460 R.YLQEIYNSNNQKIVNLKEK.V 3 3.690 0.198
Supplementary Table 1 230 S.PTGTTEFWLGNEK.I 2 2.541 0.248 S.TPNGYDNGIIWATWK.T 2 3.685 0.373 S.YCPTTCGIADFLSTYQTK.V 2 3.234 0.332 T.GTTEFWLGNEK.I 2 2.869 0.237 T.IGEGQQHHLGGAK.Q 2 3.708 0.274 T.STADYAMFK.V 1 2.023 0.254 2 2.839 0.317 T.YNPDESSKPNMIDAATLK.S 2 3.544 0.385 V.ELEDWNGR.T 2 2.234 0.205 Y.EASILTHDSSIR.Y 2 2.236 0.195 Y.FAGGDAGDAFDGFDFGDDPSDK.F 2 6.022 0.521 Y.LQEIYNSNNQK.I 2 3.523 0.111 Y.NPDESSKPNMIDAATLK.S 2 3.860 0.352 P02751 homo sapiens (human). IPI:IPI00102075.1 SW:FINC_HUMAN fibronectin precursor (fn) (cold- -.YEVSVYALK.D 2 2.230 0.174 A, G, O, P (98%) insoluble globulin) (cig). 10/2001 I.PVNLPGEHGQR.L 2 2.778 0.157 I.YLYTLNDNAR.S 2 3.087 0.336 K.DDKESVPISDTIIPAVPPPTDLR.F 2 2.407 0.318 K.DTLTSRPAQGVVTTLENVSPPR.R 2 3.251 0.279 K.EINLAPDSSSVVVSGLMVATK.Y 2 4.759 0.386 K.FTQVTPTSLSAQWTPPNVQLTGYR.V 2 4.460 0.303 K.HYQINQQWER.T 2 3.424 0.330 K.IYLYTLNDNAR.S 1 2.408 0.214 2 3.676 0.335 K.LGVRPSQGGEAPR.E 2 3.684 0.299 K.TETITGFQVDAVPANGQTPIQR.T 2 4.487 0.444 3 4.236 0.355 K.TPFVTHPGYDTGNGIQLPGTSGQQPS 3 4.426 0.421 VGQQMIFEEHGFR.R K.TYHVGEQWQK.E 1 3.117 0.292 2 2.995 0.227 K.VFAVSHGR.E 1 1.857 0.124 2 2.362 0.112 K.VTIMWTPPESAVTGYR.V 2 3.225 0.267 K.VVTPLSPPTNLHLEANPDTGVLTVSWE 2 2.429 0.342 R.S 3 3.948 0.386 K.WLPSSSPVTGYR.V 2 2.667 0.187 L.GVRPSQGGEAPR.E 2 3.158 0.370 M.VQPQSPVAVSQ.S 2 3.532 0.331 P.GGEPSPEGTTGQSYNQYSQR.Y 2 5.457 0.592 R.DAPIVNK.V 1 2.053 0.169 R.DLEVVAATPTSLLISWDAPAVTVR.Y 2 5.525 0.503 R.DLQFVEVTDVK.V 2 3.902 0.293 R.EESPLLIGQQSTVSDVPR.D 2 4.420 0.410 R.ESKPLTAQQTTK.L 2 2.872 0.166 R.FLATTPNSLLVSWQPPR.A 2 4.190 0.371 3 4.332 0.190 R.FTNIGPDTMR.V 2 2.856 0.128 R.GATYNIIVEALK.D 2 3.768 0.343 R.GATYNIIVEALKDQQR.H 2 4.342 0.366 R.GDSPASSKPISINYR.T 2 3.124 0.430 R.HTSVQTTSSGSGP.F 2 2.863 0.352 R.HTSVQTTSSGSGPFTDVR.A 2 5.643 0.552 3 5.248 0.355 R.IGDQWDK.Q 1 1.933 0.117 2 2.523 0.127 R.IGDTWSK.K 2 2.245 0.187 R.ITYGETGGNSPVQEFTVPGSK.S 2 4.589 0.321 R.IVYSPSVEGSSTELNLPETAN.S 2 4.002 0.431 R.NLQPASEYTVSLVAIK.G 2 3.125 0.292 R.NTFAEVTGLSPGVTYYFK.V 1 2.318 0.212 2 5.039 0.499
Supplementary Table 1 231 R.PAQGVVTTLENVSPPR.R 2 2.445 0.351 R.PRPGVTEATITGLEPGTEYTIYVIALK.N 3 6.121 0.312 R.QAQQMVQPQSPVAVSQSK.P 2 4.742 0.445 3 4.434 0.294 R.QYNVGPSVSK.Y 1 1.813 0.178 R.QYNVGPSVSKYPLR.N 2 4.070 0.358 R.RPGGEPSPEGTTGQ.S 2 3.676 0.378 R.RPGGEPSPEGTTGQSYNQYSQ.R 2 4.273 0.503 R.RPGGEPSPEGTTGQSYNQYSQR.Y 2 4.735 0.321 3 6.785 0.463 R.SSPVVIDASTAIDAPSNLR.F 2 5.624 0.439 R.SYTITGLQPGTDYK.I 1 2.613 0.290 2 4.465 0.366 R.TDSTTSNYEQDQK.Y 2 3.552 0.106 R.TKTETITGFQVDAVPANGQTPIQR.T 2 4.512 0.471 R.TNTNVNCPIECFMPLDVQADR.E 2 2.769 0.112 R.VDVIPVNLPGEHGQR.L 1 2.474 0.277 2 3.101 0.320 R.VEYELSEEGDEPQYLDLPSTATSVNIP 2 3.384 0.330 DLLPGR.K 3 4.513 0.350 R.VEYELSEEGDEPQYLDLPSTATSVNIP 3 6.639 0.437 DLLPGRK.Y R.VGDTYERPK.D 2 2.534 0.195 R.VPGTSTSATLTGLTR.G 2 3.371 0.493 R.VTWAPPPSIDLTNFLVR.Y 2 3.025 0.171 R.WSRPQAPITGYR.I 2 3.300 0.284 3 3.521 0.156 S.RPQAPITGYR.I 2 3.855 0.303 T.SLSAQWTPPNVQLTGYR.V 2 2.358 0.232 W.LPSSSPVTGYR.V 2 2.568 0.248 W.SRPQAPITGYR.I 2 3.453 0.327 Y.AVEENQESTPVVIQQETTGTPR.S 2 5.342 0.436 Q01543 homo sapiens (human). fli-1 IPI:IPI00217470.1 SW:FLI1_HUMAN oncogene (ergb transcription factor). A.SQYWTSPTGGIYPNPNVPRHPNTHV.P 2 2.854 0.098 P (99%) 10/2001 P36888 homo sapiens (human). fl cytokine receptor precursor (ec IPI:IPI00005722.1 SW:FLT3_HUMAN 2.7.1.112) (tyrosine-protein kinase T.FEDLLCFAYQV.A 1 2.129 0.138 O (98%) receptor flt3) (stem cell tyrosine kinase 1) (stk-1) (cd135 antigen). 10/2001 Q9ha64 homo sapiens (human). hypothetical fructosamine kinase-like IPI:IPI00099986.1 SW:FN3X_HUMAN L.EIIPALLHGDLW.G 2 2.612 0.132 P protein flj12171/dkfzp564d202. (96%) 10/2001 Q9h4m3 homo sapiens (human). f-box SW:FX30_HUMAN F.EFWSLDVNGGDEWKVEDLS.R 2 3.458 0.091 O protein fbx30. 10/2001 Q9uju5 homo sapiens (human). IPI:IPI00003449.1 SW:FXD3_HUMAN forkhead box protein d3 (hnf3/fh A.EDVDIDVVGEGDDGLE.E 1 2.110 0.084 G, P (93%) transcription factor genesis). 5/2000 D.VGAPEADGCKGGVGGEEGGASGGGP 2 2.664 0.225 GA.G Q12947 homo sapiens (human). forkhead box protein f2 (forkhead- related protein fkhl6) (forkhead- SW:FXF2_HUMAN K.SAGGGGAGAGSGGAKKASSGLRR.P 2 2.468 0.110 A, O, P related transcription factor 2) (freac-2) (forkhead-related activator- 2). 10/2001 L.GFGASLLPQGFDFQA.P 2 3.184 0.083 O75593 homo sapiens (human). forkhead box protein h1 (forkhead IPI:IPI00026214.1 SW:FXH1_HUMAN activin signal transducer 1) (fast- 1) R.VEGETVQ.G 1 2.246 0.101 G, O, P (93%) (hfast-1) (forkhead activin signal transducer 2) (fast-2). 5/2000 V.QGGAIGPSTLSPEP.R 2 2.829 0.219 Q9p0k8 homo sapiens (human). SW:FXJ2_HUMAN forkhead box protein j2 (fork head P.GPSPMYPIPTQDSAGYNR.P 1 2.013 0.127 P homologous x). 10/2001 P58012 homo sapiens (human). A.APPPAPPHHGAAAPPPGQLSPASPAT SW:FXL2_HUMAN 2 2.421 0.121 O, P forkhead box protein l2. 10/2001 AAP.P Supplementary Table 1 232 P.EGPPPSPGKGGGGGGGTAPEK.P 2 2.312 0.148 P51114 homo sapiens (human). SW:FXR1_HUMAN fragile x mental retardation syndrome K.KEISEGDEVEVYSRANDQE.P 2 2.748 0.289 G related protein 1. 10/2001 Q16186 homo sapiens (human). 110 SW:G100_HUMAN kda cell membrane glycoprotein. A.GLGGLGGLGALTGPGLASLLGSSG.P 1 2.051 0.139 G 10/2001 I.LATMNVPAGPAGGQQVDLASVLTPEIM 3 3.941 0.227 APILANADV.Q O95479 homo sapiens (human). gdh/6pgl endoplasmic bifunctional protein precursor [includes: glucose 1- IPI:IPI00008266.1 SW:G6PE_HUMAN G.SPAVLVSRNLFRPSLPSSWK.E 2 2.325 0.132 A, G dehydrogenase (ec 1.1.1.47) (hexose- (99%) 6-phosphate dehydrogenase); 6- phosphogluconolacto R.DQNRKALDGLWNRH.H 2 2.560 0.085 O75325 homo sapiens (human). SW:GAC1_HUMA IPI:IPI00025256.1 glioma amplified on chromosome 1 W.FEMLPNLEILMIGGNK.V 2 2.564 0.134 P N (95%) protein precursor. 10/2001 O14976 homo sapiens (human). cyclin SW:GAK_HUMAN g-associated kinase (ec 2.7.1.-). K.ESESALMEDRDESE.V 2 3.027 0.176 A 10/2001 P50440 homo sapiens (human). glycine amidinotransferase, SW:GATM_HUMA IPI:IPI00032103.1 mitochondrial precursor (ec 2.1.4.1) (l- C.FDAADFIRAGRDIFAQR.S 2 2.400 0.289 A, G N (97%) arginine:glycine amidinotransferase) (transamidinase) (at). 10/2001 L.KSTQAATASSRNSCAADDK.A 1 2.191 0.136 Q92538 homo sapiens (human). golgi- specific brefeldin a-resistance guanine IPI:IPI00021954.1 SW:GBF1_HUMAN V.RMQALTYLQR.A 1 2.265 0.200 G nucleotide exchange factor 1 (bfa- (92%) resistant gef 1). 10/2001 P32455 homo sapiens (human). interferon-induced guanylate-binding IPI:IPI00028564.1 SW:GBP1_HUMAN E.RSYQEHLK.Q 1 1.985 0.117 G protein 1 (guanine nucleotide- binding (94%) protein 1). 2/1996 P11488 homo sapiens (human). guanine nucleotide-binding protein IPI:IPI00218488.1 SW:GBT1_HUMAN K.LKEDAEKDARTVKLLLLGAGESGKST.I 2 2.756 0.177 G g(t), alpha-1 subunit (transducin (95%) alpha-1 chain). 10/2001 P01860 homo sapiens (human). ig IPI:IPI00004608.1 SW:GC3_HUMAN gamma-3 chain c region (heavy chain C.SVMHEALHNR.Y 2 3.332 0.307 G (93%) disease protein) (hdc). 10/2001 D.VSHEDPEVQFK.W 2 2.420 0.250 E.VTCVVVDVSHEDPEVQFK.W 2 2.510 0.337 K.GFYPSDIAVEWESSGQPENNYN.T 2 3.687 0.285 K.GFYPSDIAVEWESSGQPENNYNTTPP 3 4.024 0.300 MLDSDGSFF.L K.NQVSLTCPVKGFYP.S 2 2.782 0.157 K.TPLGDTTHTCPR.C 2 3.539 0.357 K.TPLGDTTHTCPRCPEPK.S 2 2.980 0.190 3 4.048 0.398 L.TVLHQNWLDGKEYK.C 2 2.619 0.150 N.WLDGKEYK.C 1 1.924 0.141 P.CPRCPAPELLGGPSVFLFPPKPK.D 2 2.922 0.292 P.PPCPRCPAPELLGGPSVFLFPPKPK.D 2 2.648 0.192 Q.FKWYVDGVEVHNAK.T 2 3.082 0.154 R.TPEVTCVVVDVSHEDPEVQFK.W 2 3.132 0.158 R.VVSVLTVLHQN.W 2 2.817 0.175 R.VVSVLTVLHQNWLDGK.E 2 3.111 0.125 R.VVSVLTVLHQNWLDGKEYK.C 3 3.956 0.387 S.VLTVLHQNWLDGK.E 2 2.321 0.195 S.VMHEALHNR.Y 2 3.098 0.301 T.PPPCPRCPAPELLGGPSVFLFPPKPK.D 2 2.327 0.216 V.SVLTVLHQNWLDGK.E 2 3.237 0.208 V.SVLTVLHQNWLDGKEYK.C 2 2.871 0.088 V.VSVLTVLHQNWLDGK.E 2 2.372 0.194 V.VSVLTVLHQNWLDGKEYK.C 2 2.914 0.254 P01861 homo sapiens (human). ig IPI:IPI00004618.1 SW:GC4_HUMAN K.TTPPVLDSDGSFFLYSR.L 2 2.276 0.175 G gamma-4 chain c region. 10/2001 (95%) P.SCPAPEFLGGPSVFLFPPKPK.D 2 2.473 0.202 Supplementary Table 1 233 R.VESKYGPPCPSCPAPEFLGGPSVFLFP 3 3.641 0.252 PKPK.D S.CPAPEFLGGPSVFLFPPKPK.D 2 2.513 0.249 T.PPVLDSDGSFFLYSR.L 2 2.780 0.176 Y.GPPCPSCPAPEFLGGPSVFLFPPKPK. 3 4.287 0.312 D P16383 homo sapiens (human). gc- SW:GCF_HUMAN rich sequence dna-binding factor (gcf) E.SSSDKKVLSAII.N 2 3.142 0.123 O, P (transcription factor 9) (tcf-9). 10/2001 Q14397 homo sapiens (human). SW:GCKR_HUMA IPI:IPI00030293.1 glucokinase regulatory protein K.GHVYLVGW.Q 1 1.906 0.110 A N (97%) (glucokinase regulator). 10/2001 P23378 homo sapiens (human). glycine dehydrogenase SW:GCSP_HUMA [decarboxylating], mitochondrial IPI:IPI00144164.1 Y.DQVCFQPNSGAQGEYAGLATI.R 2 3.414 0.246 P N precursor (ec 1.4.4.2) (glycine (96%) decarboxylase) (glycine cleavage system p- protein). 10/2001 M.SDESYRLGQGSFGEVWPLDR.Y 2 3.369 0.238 P16260 homo sapiens (human). grave's disease carrier protein (gdc) IPI:IPI00166484.1 SW:GDC_HUMAN (grave's disease autoantigen) (gda) V.GLSHAPTLLGSPSSDNPNVLVLK.T 2 2.711 0.202 P (97%) (mitochondrial solute carrier protein homolog). 10/2001 P06396 homo sapiens (human). gelsolin precursor, plasma (actin- IPI:IPI00026314.1 SW:GELS_HUMAN -.PNSMVVEHPEFLK.A 2 4.103 0.419 A, O, P depolymerizing factor) (adf) (brevin) (97%) (agel). 10/2001 A.ATASRGASQAGAPQGR.V 2 2.628 0.212 A.GALNSNDAFVLK.T 1 2.877 0.301 F.FTGDAYVILK.T 2 2.676 0.117 F.LGWDDDYWSVDPLDR.A 2 3.061 0.272 K.AGALNSNDAFVLK.T 1 2.723 0.138 2 3.905 0.388 K.AGKEPGLQIWR.V 2 3.186 0.331 3 3.517 0.102 K.DSQEEEKTEALTSAK.R 1 1.974 0.232 2 3.935 0.296 3 3.551 0.306 K.EPAHLMSLFGGKPMIIYK.G 2 2.951 0.366 K.FDLVPVPTNLYGDFFTGDAYVILK.T 2 2.967 0.516 K.GGTSREGGQTAPASTR.L 2 3.642 0.232 K.GGVASGFK.H 1 1.849 0.176 K.HVVPNEVVVQR.L 1 2.779 0.292 2 3.467 0.422 K.KGGVASGFK.H 2 2.344 0.204 K.KMDAHPPR.L 2 2.272 0.217 K.NWRDPDQTDGLGLSYLSSH.I 2 2.968 0.273 K.NWRDPDQTDGLGLSYLSSHIANVER.V 2 3.131 0.441 3 7.560 0.446 K.PALPAGTEDTAK.E 1 2.406 0.386 2 2.863 0.304 K.PALPAGTEDTAKEDAANR.K 2 3.518 0.470 K.PALPAGTEDTAKEDAANRK.L 2 4.180 0.533 K.QTQVSVLPEGGETPLFK.Q 2 3.991 0.416 K.RYIETDPANR.D 2 2.783 0.239 K.TASDFITK.M 1 1.963 0.129 K.TPSAAYLWVGTGASEAEK.T 2 5.403 0.489 K.TPSAAYLWVGTGASEAEKTGAQELLR. 3 5.854 0.461 V K.VSNGAGTMSVSLVADENPFAQGALK.S 2 4.115 0.317 M.SVSLVADENPFAQGALK.S 2 3.216 0.335 N.SMVVEHPEFLK.A 2 3.414 0.231 R.ANSAGATRAVEVLPK.A 2 3.285 0.098 R.AQPVQVAEGSEPDGFWEALGGK.A 2 6.235 0.297 3 4.465 0.321 R.AVEVLPK.A 1 1.974 0.131 R.DPDQTDGLGLSYLSSHIANVER.V 2 2.217 0.200 Supplementary Table 1 234 3 4.865 0.379 R.EGGQTAPASTR.L 2 2.404 0.326 R.EVQGFESATFLGYFK.S 2 3.919 0.481 R.FVIEEVPGELMQEDLATDDVMLLDTWD 3 3.901 0.340 QVFVWVGKDSQEEEK.T R.GASQAGAPQGR.V 1 2.082 0.157 2 3.169 0.172 R.IEGSNKVPVDPATYGQFYGGDSYIILYN 3 4.807 0.385 YR.H R.QGQIIYNWQGAQ.S 2 3.128 0.217 R.RTPITVVK.Q 2 2.310 0.162 R.VHVSEEGTEPEAM.L 2 3.284 0.431 R.VHVSEEGTEPEAMLQVLGPK.P 2 2.980 0.283 R.VHVSEEGTEPEAMLQVLGPKPALPAG 3 5.702 0.411 TEDTAK.E R.VHVSEEGTEPEAMLQVLGPKPALPAG 3 5.285 0.393 TEDTAKEDAANR.K R.VHVSEEGTEPEAMLQVLGPKPALPAG 3 4.600 0.455 TEDTAKEDAANRK.L R.VPEARPNSMVVEHPEFLK.A 2 3.563 0.309 3 4.524 0.254 R.VPFDAATLHTSTAMAAQHGMDDDGTG 3 6.115 0.535 QK.Q R.VVQGKEPAHLMSLFGGKPMIIYK.G 3 5.669 0.441 R.YIETDPANR.D 1 1.924 0.366 2 3.314 0.306 V.PNEVVVQR.L 1 1.821 0.239 Q9ujy5 homo sapiens (human). adp- ribosylation factor binding protein SW:GGA1_HUMA gga1 (golgi-localized, gamma ear- L.PASSGLDDLDLLGKTL.L 1 2.324 0.106 P N containing, arf-binding protein 1) (gamma-adaptin related protein 1). 10/2001 Q92820 homo sapiens (human). gamma-glutamyl hydrolase precursor IPI:IPI00023728.1 SW:GGH_HUMAN (ec 3.4.19.9) (gamma-glu-x S.LELSRPHGDTAK.K 2 2.881 0.223 P (95%) carboxypeptidase) (conjugase) (gh). 10/2001 Q92896 homo sapiens (human). golgi apparatus protein 1 precursor (golgi sialoglycoprotein mg-160) (e-selectin F.PAGGPPARRGGAGAGGGWKLAEEES IPI:IPI00179882.1 SW:GLG1_HUMAN 3 3.782 0.162 O ligand 1) (esl-1) (cysteine-rich CREDVTRVC.P (96%) fibroblast growth factor receptor) (cfr- 1). 1 P10070 homo sapiens (human). zinc SW:GLI2_HUMAN finger protein gli2 (tax helper protein). T.DGGLAR.G 1 1.865 0.138 A, G, O, P 10/2001 Y.DTQEQLVHHINNEHIHGEKKEFV.C 2 2.983 0.231 Q16099 homo sapiens (human). glutamate receptor, ionotropic kainate IPI:IPI00032247.1 SW:GLK4_HUMAN 4 precursor (glutamate receptor ka-1) L.DTKGYGIGMPVGSV.F 2 2.636 0.217 A (94%) (ka1) (excitatory amino acid receptor 1) (eaa1). 10/2001 P47871 homo sapiens (human). Y.LHNLLGLATLPERSFFSLYLGIGWGAP IPI:IPI00026640.1 SW:GLR_HUMAN glucagon receptor precursor (gl-r). 3 4.260 0.199 A, G, O, P MLF.V (94%) 10/2001 P36915 homo sapiens (human). SW:GNL1_HUMAN guanine nucleotide-binding protein-like R.QLQVLAGIYPIAQIQEPYTA.V 2 2.967 0.081 O 1 (gtp-binding protein hsr1). 10/2001 Q13439 homo sapiens (human). golgi SW:GOG4_HUMA autoantigen, golgin subfamily a 4 E.LSRVKQEVVDVMKKSSEEQIAK.L 2 2.633 0.124 A N (trans-golgi p230) (256 kda golgin) (golgin-245) (72.1 protein). 10/2001 R.LRRMERSLSSYRGKYSELVTAYQMLQ 3 3.568 0.135 REKKK.L O43193 homo sapiens (human). E.RRCSPFPLGALVPVTAVCLCLFVVGVS SW:GP38_HUMAN putative g protein-coupled receptor 3 3.576 0.174 G, P GNVVTVMLIGR.Y gpr38. 10/2001 L.LHMTALSVERYLA.I 1 2.370 0.120 P51654 homo sapiens (human). SW:GPC3_HUMA IPI:IPI00019907.1 glypican-3 precursor (intestinal protein G.IEVINTTDHLKFSK.D 2 2.551 0.109 O, P N (94%) oci-5) (gtr2-2) (mxr7). 10/2001 SW:GPRZ_HUMA Q9hc97 homo sapiens (human). Q.AAAVCAVLWVLVIGSLVAR.W 2 3.075 0.086 O Supplementary Table 1 235 N probable g protein-coupled receptor gpr35. 10/2001 P38646 homo sapiens (human). stress-70 protein, mitochondrial precursor (75 kda glucose regulated IPI:IPI00180885.1 SW:GR75_HUMAN R.RDYASEAIKGAVVGIDLG.T 1 2.183 0.218 P protein) (grp 75) (peptide-binding (97%) protein 74) (pbp74) (mortalin) (mot). 10/2001 P11021 homo sapiens (human). 78 kda glucose-regulated protein precursor (grp 78) (immunoglobulin IPI:IPI00003362.1 SW:GR78_HUMAN K.AVEEKIEWLESHQDAD.I 2 3.047 0.205 O, P heavy chain binding protein) (bip) (98%) (endoplasmic reticulum lumenal ca2+ binding protein grp7 K.NQLTSNPENTVFDAK.R 2 2.595 0.205 R.ITPSYVAFTPEGER.L 2 2.646 0.257 O95249 homo sapiens (human). 28 kda golgi snare protein (golgi snap SW:GS28_HUMAN R.FPAVNSLIQRINLRK.R 2 2.811 0.085 A receptor complex member 1) (28 kda cis-golgi snare p28) (gos-28). 10/2001 P36969 homo sapiens (human). phospholipid hydroperoxide SW:GSHH_HUMA glutathione peroxidase, mitochondrial G.KTEVNYTQLVDL.H 2 2.602 0.112 O N precursor (ec 1.11.1.9) (phgpx) (gpx- 4). 10/2001 P22352 homo sapiens (human). SW:GSHP_HUMA plasma glutathione peroxidase IPI:IPI00026199.1 K.FLVGPDGIPIMR.W 2 3.214 0.231 O, P N precursor (ec 1.11.1.9) (gshpx-p). (94%) 5/2000 K.YVRPGGGFVPNFQLFEK.G 2 3.998 0.372 Q9nzm4 homo sapiens (human). SW:GSR1_HUMA glioma tumor suppressor candidate G.TPSGQPLAVAPGL.G 2 2.518 0.103 A, O, P N region gene 1 protein. 10/2001 K.GPPPEPAASAAQGTGDP.D 2 2.608 0.152 R.PPSRPPSRPQSVS.R 1 2.021 0.108 Q9y2q3 homo sapiens (human). glutathione s-transferase, mitochondrial (ec 2.5.1.18) (gst 13-13) SW:GTK1_HUMAN P.KDFLSVMLEK.G 2 2.730 0.154 A (glutathione s-transferase subunit 13) (gst class-kappa) (hdcmd47p). 10/2001 P11169 homo sapiens (human). IPI:IPI00003909.1 SW:GTR3_HUMAN glucose transporter type 3, brain. F.CGLCTGFVPMYIGEISPTALR.G 2 2.632 0.102 P (93%) 10/2001 G.INAVFYYSTGIFKDA.G 1 2.407 0.107 P22732 homo sapiens (human). glucose transporter type 5, small IPI:IPI00216971.1 SW:GTR5_HUMAN I.GHALGPSPIPA.L 1 2.312 0.116 G, O, P intestine (fructose transporter). (93%) 10/2001 V.TAGTGAVNVVM.T 1 2.737 0.131 P10412 homo sapiens (human). SW:H14_HUMAN K.AGAAKAKKPAGAAK.K 1 1.903 0.105 G histone h1.4 (histone h1b). 10/2001 Q93077 homo sapiens (human). R.GKQGGKARAKAKSRSSRAGLQFPVGR IPI:IPI00081836.1 SW:H2AL_HUMAN 3 3.531 0.095 A histone h2a.l (h2a/l). 10/2001 VHRLLRK.G (99%) Q93080 homo sapiens (human). IPI:IPI00152785.1 SW:H2BL_HUMAN K.HAVSEGTKAVTKYTSSK.- 3 4.464 0.505 P histone h2b.l (h2b/l). 10/2001 (98%) O14626 homo sapiens (human). IPI:IPI00023057.1 SW:H963_HUMAN probable g protein-coupled receptor C.LQLTHSCK.I 1 1.987 0.175 G (95%) h963. 10/2001 Q92839 homo sapiens (human). hyaluronan synthase 1 (ec 2.4.1.-) SW:HAS1_HUMAN (hyaluronate synthase 1) (hyaluronic L.ELVRVLDEDPRVGAVGGDVRILNP.L 2 3.362 0.128 A acid synthase 1) (ha synthase 1) (huhas1). 10/2001 O00219 homo sapiens (human). hyaluronan synthase 3 (ec 2.4.1.-) IPI:IPI00010846.1 SW:HAS3_HUMAN (hyaluronate synthase 3) (hyaluronic F.MSLYSLLYMSSLL.P 2 2.602 0.133 P (96%) acid synthase 3) (ha synthase 3). 10/2001 P01922 homo sapiens (human), pan troglodytes (chimpanzee), and pan K.KVADALTNAVAHVDDMPNALSALSDLH SW:HBA_HUMAN paniscus (pygmy chimpanzee) 3 6.928 0.431 O, P AHK.L (bonobo). hemoglobin alpha chain. 10/2001 K.LRVDPVNFK.L 2 2.422 0.219
Supplementary Table 1 236 K.MFLSFPTTK.T 2 2.834 0.102 K.TYFPHFDLSHGSAQVK.G 2 2.572 0.366 K.VADALTNAVAHVDDMPNALSALSDLHA 3 6.656 0.478 HK.L K.VGAHAGEYGAEALER.M 2 4.181 0.414 M.VLSPADKTNVK.A 2 2.611 0.195 P02023 homo sapiens (human), pan troglodytes (chimpanzee), and pan IPI:IPI00009944.1 SW:HBB_HUMAN paniscus (pygmy chimpanzee) E.SFGDLSTPDAVMGNPK.V 1 3.164 0.417 O, P (97%) (bonobo). hemoglobin beta chain. 10/2001 K.SAVTALWGK.V 1 2.177 0.321 2 2.637 0.220 K.VNVDEVGGEALGR.L 1 2.659 0.188 2 4.679 0.385 M.VHLTPEEK.S 1 2.460 0.175 2 2.831 0.109 R.FFESFGDLSTPDAVMGNPK.V 2 4.818 0.428 P02042 homo sapiens (human). IPI:IPI00067590.1 SW:HBD_HUMAN K.EFTPPVQAAYQK.V 1 1.962 0.180 O, P hemoglobin delta chain. 7/1998 (97%) 2 3.007 0.302 K.VLGAFSDGLAHLDNLK.G 2 4.829 0.448 K.VVAGVANALAHK.Y 2 3.492 0.315 K.VVAGVANALAHKYH.- 2 4.288 0.419 L.LVVYPWTQR.F 2 2.632 0.136 R.LLVVYPWTQR.F 2 2.879 0.088 Q92769 homo sapiens (human). SW:HDA2_HUMAN Q.QTDMAVNWAGGLHHAK.K 1 2.548 0.109 A histone deacetylase 2 (hd2). 10/2001 P02790 homo sapiens (human). SW:HEMO_HUMA IPI:IPI00022488.1 hemopexin precursor (beta-1b- A.EGETKPDPDVTER.C 2 2.647 0.265 G, O, P N (93%) glycoprotein). 10/2001 A.FSGTHYWR.L 2 2.311 0.232 A.HGNVAEGETKPDPDVTER.C 2 4.770 0.528 3 4.706 0.382 A.LTSDNHGATYA.F 2 2.697 0.264 A.TPLPPTSAHGNVAEGETKPDPDVTER. 2 3.350 0.396 C 3 3.684 0.323 C.SPHLVLSALTSDNHGATYAFSGTHYW 3 3.820 0.269 R.L F.PSPVDAAFR.Q 1 2.305 0.297 G.HNSVFLIK.G 2 2.581 0.136 G.NVAEGETKPDPDVTER.C 2 4.445 0.364 H.GNVAEGETKPDPDVTER.C 2 4.392 0.463 H.QWPQGPSAVDAAFSWEEK.L 2 3.198 0.337 K.EVGTPHGIILDSVDAA.F 2 2.567 0.172 K.GDKVWVYPPEK.K 1 2.528 0.193 2 3.343 0.346 K.GDKVWVYPPEKK.E 1 2.993 0.264 2 3.780 0.240 K.GGYTLVSGYPK.R 1 2.475 0.277 2 3.864 0.300 K.LLQDEFPGIPSPL.D 2 3.658 0.261 K.LLQDEFPGIPSPLDAAVECHRGECQAE 3 5.752 0.445 GVLFFQGDR.E K.LYLVQGTQVYVFLTK.G 2 5.505 0.468 3 4.039 0.388 K.NFPSPVD.A 1 1.842 0.149 K.NFPSPVDAAFR.Q 1 2.532 0.247 2 2.591 0.328 K.SGAQATWTELPWPHEK.V 1 3.371 0.374 2 4.954 0.477 3 5.123 0.340 K.SHKWDRELISER.W 2 3.549 0.253 K.SLGPNSCSANGPGLYLIHGPNLYCYSD 3 3.594 0.318 VEK.L K.SLGPNSCSANGPGLYLIHGPNLYCYSD 3 4.085 0.246 Supplementary Table 1 237 VEKLNAAK.A K.VWVYPPEK.K 1 2.454 0.160 K.VWVYPPEKK.E 1 2.082 0.126 2 2.699 0.178 K.WDRELISER.W 2 2.855 0.099 L.PPTSAHGNVAEGETKPDPDVTER.C 2 5.007 0.344 3 5.543 0.347 L.SALTSDNHGATYAFSGTHYWR.L 3 5.507 0.458 L.TSDNHGATYAFSGTHYWR.L 2 5.190 0.525 3 4.788 0.388 N.FPSPVDAAFR.Q 2 2.927 0.335 N.STHHGPEYMR.C 2 2.402 0.268 N.VAEGETKPDPDVTER.C 1 2.407 0.273 2 3.975 0.336 3 3.727 0.326 P.LPPTSAHGNVAEGETKPDPDVTER.C 2 4.529 0.441 3 4.115 0.364 P.PTSAHGNVAEGETKPDPDVTER.C 3 3.814 0.390 P.SPVDAAFR.Q 1 1.854 0.250 2 2.825 0.319 P.TSAHGNVAEGETKPDPDVTER.C 2 5.108 0.447 3 4.569 0.366 Q.GHNSVFLIK.G 2 2.529 0.166 R.CSPHLVLSALTSDNHGATYAFSGTHY 3 3.895 0.368 WR.L R.DGWHSWPIAHQWPQGPSAVDA.A 2 4.440 0.410 R.DGWHSWPIAHQWPQGPSAVDAA.F 2 4.396 0.458 R.DGWHSWPIAHQWPQGPSAVDAAFSW 2 4.010 0.461 EEK.L 3 6.086 0.417 R.EWFWDLATGTMK.E 1 2.582 0.333 2 3.968 0.383 R.LHIMAGR.R 1 2.370 0.215 R.QGHNSVFLIK.G 2 2.614 0.124 R.QGHNSVFLIKGDK.V 2 3.504 0.361 R.RLWWLDLK.S 2 2.748 0.155 R.WKNFPSPVDAAFR.Q 2 3.693 0.293 3 3.971 0.338 S.AHGNVAEGETKPDPDVTER.C 3 3.507 0.364 S.ALTSDNHGATYA.F 2 3.264 0.346 S.ALTSDNHGATYAFSGTHYWR.L 3 5.067 0.411 T.YAFSGTHYWR.L 2 2.982 0.449 W.KNFPSPVDAAF.R 2 2.416 0.377 W.KNFPSPVDAAFR.Q 2 3.352 0.279 Y.AFSGTHYWR.L 2 2.926 0.373 P05546 homo sapiens (human). heparin cofactor ii precursor (hc-ii) IPI:IPI00219388.1 SW:HEP2_HUMAN K.FAFNLYR.V 1 2.045 0.243 O, P (protease inhibitor leuserpin 2) (hls2). (97%) 10/2001 K.GETHEQVHSILHFK.D 2 4.370 0.430 3 3.619 0.297 K.GGETAQSADPQWEQLNNK.N 2 5.661 0.400 K.GPLDQLEK.G 1 2.104 0.131 2 2.250 0.136 K.NGNMAGISDQR.I 2 3.803 0.389 K.NYNLVESLK.L 1 3.077 0.171 2 3.375 0.113 K.QFPILLDFK.T 2 2.990 0.305 K.TLEAQLTPR.V 2 3.368 0.325 K.TNNHIMK.L 2 2.851 0.179 K.VSMMQTK.G 1 1.936 0.137 2 2.443 0.130 K.YEITTIHNLFR.K 2 3.391 0.401 Q.IADFSDPAFISK.T 2 3.334 0.429 R.EVLLPK.F 1 2.008 0.123 Supplementary Table 1 238 R.EYYFAEAQIADFSDPAFISK.T 2 5.922 0.502 R.FTVDRPFLFLIYEHR.T 3 4.928 0.334 R.MLFDKNGNMAGISDQR.I 2 3.541 0.197 R.SVNDLYIQK.Q 2 3.049 0.319 Q14469 homo sapiens (human). transcription factor hes-1 (hairy and C.MTQINAMTYPGQPHPALQAPPPPPPG SW:HES1_HUMAN 3 3.870 0.116 P enhancer of split 1) (hairy- like) (hhl) PGGPQHAPF.A (hairy homolog). 12/1998 Q30201 homo sapiens (human). IPI:IPI00030171.1 SW:HFE_HUMAN hereditary haemochromatosis protein I.LFIILR.K 1 1.804 1.000 G (94%) precursor (hla-h). 10/2001 P05204 homo sapiens (human). SW:HG17_HUMAN nonhistone chromosomal protein hmg- S.LSAKPAPPKPEPKPK.R 2 2.867 0.135 P 17. 10/2001 P14210 homo sapiens (human). hepatocyte growth factor precursor IPI:IPI00025767.1 SW:HGF_HUMAN I.FVRVAYYAKWIH.K 2 2.646 0.085 G (scatter factor) (sf) (hepatopoeitin a). (97%) 10/2001 Q04756 homo sapiens (human). SW:HGFA_HUMA hepatocyte growth factor activator IPI:IPI00029193.1 K.YIPYTLYSVFNPSDHDLVLIR.L 2 2.730 0.380 O, P N precursor (ec 3.4.21.-) (hgf activator) (92%) (hgfa). 10/2001 R.VQLSPDLLATLPEPASPGR.Q 2 4.892 0.454 R.YEYLEGGDR.W 2 2.219 0.141 P26927 homo sapiens (human). hepatocyte growth factor-like protein IPI:IPI00028210.2 SW:HGFL_HUMAN precursor (macrophage stimulatory R.WDAQIPHQHR.F 2 3.425 0.348 A, O, P (97%) protein) (msp) (macrophage stimulating protein). 10/2001 V.YLRTACTTGGELLPDPDG.D 1 2.195 0.174 Q16665 homo sapiens (human). hypoxia-inducible factor 1 alpha (hif-1 IPI:IPI00003442.1 SW:HIFA_HUMAN alpha) (arnt interacting protein) I.YNTKNSQPQCIVCVNYVVSGIIQHDL.I 3 4.026 0.155 A (93%) (member of pas protein 1) (mop1) (hif1 alpha). 10/2001 O00291 homo sapiens (human). IPI:IPI00220730.1 SW:HIP1_HUMAN huntingtin interacting protein 1 (hip-i) A.QLVAASK.V 1 2.176 0.116 A (96%) (fragment). 10/2001 P19622 homo sapiens (human). SW:HME2_HUMA homeobox protein engrailed-2 (hu-en- P.GDGEGGSKTLSLHGGA.K 1 2.261 0.188 G N 2). 10/2001 P00738 homo sapiens (human). IPI:IPI00019572.1 SW:HPT2_HUMAN A.FAVHDLEEDTWYATGILSFDK.S 2 6.448 0.602 A, G, O, P haptoglobin-2 precursor. 10/2001 (92%) A.HGYVEHSVR.Y 2 3.164 0.246 A.VDSGNDVTDIADDGCPKPPEIAHGYVE 2 3.576 0.337 HSVR.Y 3 5.376 0.423 C.PKPPEIAHGYVEHSVR.Y 2 3.281 0.426 D.DGCPKPPEIAHGYVEHSVR.Y 2 2.506 0.080 G.CPKPPEIAHGYVEHSVR.Y 1 2.108 0.105 G.YVEHSVR.Y 2 2.259 0.229 H.DLEEDTWYATGILSFDK.S 2 3.165 0.281 H.GYVEHSVR.Y 1 1.913 0.142 H.YEGSTVPEKK.T 2 3.174 0.386 K.DYAEVGR.V 1 2.435 0.213 2 2.468 0.171 K.LRTEGDGVYTLNN.E 2 3.083 0.141 K.LRTEGDGVYTLNNEK.Q 1 3.467 0.323 2 5.680 0.403 3 3.689 0.162 K.LRTEGDGVYTLNNEKQWINK.A 2 5.472 0.402 3 3.795 0.170 K.PPEIAHGYVEHSVR.Y 2 3.740 0.440 K.QLVEIEKVVLHPNYSQVDIGLIK.L 3 5.216 0.252 K.SPVGVQPILNEHTFCAGMSK.Y 2 4.085 0.409 3 4.043 0.162 K.VTSIQDWVQK.T 1 2.737 0.303 2 3.816 0.296 K.VTSIQDWVQKTIAEN.- 2 4.150 0.404 K.VVLHPNYSQVDIGLIK.L 1 3.417 0.242 Supplementary Table 1 239 2 4.913 0.420 3 4.989 0.336 K.YVMLPVADQDQCIR.H 2 4.139 0.385 L.FAVDSGNDVTDIADDGCPKPPEIAHGY 3 3.550 0.224 VEHSVR.Y L.RTEGDGVYTLNNEK.Q 1 2.832 0.177 2 5.186 0.371 3 3.649 0.255 M.PICLPSKDYAEVGR.V 2 2.491 0.130 N.YSQVDIGLIK.L 1 2.394 0.227 2 3.349 0.302 R.HYEGSTVPEK.K 1 2.752 0.204 2 3.094 0.290 R.HYEGSTVPEKK.T 1 2.860 0.267 2 3.696 0.396 R.NANFKFTDHLK.Y 1 2.461 0.148 2 4.067 0.234 R.TEGDGVYTLNN.E 2 2.558 0.175 R.TEGDGVYTLNNE.K 2 2.513 0.337 R.TEGDGVYTLNNEK.Q 1 2.689 0.260 2 4.343 0.397 R.TEGDGVYTLNNEKQWINK.A 2 3.928 0.320 R.VGYVSGWGR.N 1 2.161 0.104 2 3.532 0.300 R.VMPICLPSKDYAEVGR.V 2 3.206 0.448 S.GNDVTDIADDGCPKPPEIAHGYVEHSV 3 3.583 0.337 R.Y T.EGDGVYTLNNEK.Q 2 2.815 0.339 T.SIQDWVQK.T 1 1.972 0.146 2 2.595 0.159 V.GYVSGWGR.N 2 2.571 0.328 V.TSIQDWVQK.T 1 2.411 0.311 2 3.159 0.222 V.VLHPNYSQVDIGLIK.L 2 3.756 0.296 3 4.065 0.255 V.YTLNNEK.Q 1 1.816 0.123 P00739 homo sapiens (human). SW:HPTR_HUMA IPI:IPI00019571.1 haptoglobin-related protein precursor. M.TLYVGK.D 1 1.806 0.148 O N (92%) 10/2001 P04196 homo sapiens (human). histidine-rich glycoprotein precursor SW:HRG_HUMAN D.SPVLIDF.F 1 2.289 0.178 A, G, O, P (histidine-proline rich glycoprotein) (hprg). 10/2001 D.SPVLIDFFEDTER.Y 2 3.950 0.246 K.ALDLINKR.R 2 2.350 0.173 K.DSPVLIDFFEDTER.Y 1 2.934 0.356 2 4.874 0.421 K.GEVLPLPEANFPSFPLPH.H 2 4.185 0.400 K.GEVLPLPEANFPSFPLPHHK.H 2 3.799 0.457 K.SGFPQVSMFFTHTFPK.- 2 4.276 0.276 K.YKEENDDFASFR.V 2 4.157 0.396 R.ADLFYDVEALDLESPK.N 1 4.170 0.346 2 5.034 0.387 3 4.543 0.320 R.DGYLFQLLR.I 2 3.432 0.241 R.DHHHPHKPHEHGPPPPPDER.D 3 4.417 0.490 R.DHSHGPPLPQGPPPLLPM.S 2 3.312 0.378 R.DHSHGPPLPQGPPPLLPMSCSSCQHA 3 4.487 0.329 TFGTNGAQ.R R.DHSHGPPLPQGPPPLLPMSCSSCQHA 3 6.258 0.505 TFGTNGAQR.H R.GGEGTGYFVDFSVR.N 2 3.848 0.440 R.HSHESQDLR.V 2 2.518 0.209 R.KGEVLPLPEANFPSFPLPH.H 2 4.535 0.448 R.KGEVLPLPEANFPSFPLPHHK.H 2 4.744 0.435 3 6.093 0.456 Supplementary Table 1 240 R.SSTTKPPFKPHGSR.D 2 2.423 0.220 S.PVLIDFFEDTER.Y 2 3.236 0.208 Y.DVEALDLESPK.N 2 2.231 0.186 P17066 homo sapiens (human). heat IPI:IPI00011134.1 SW:HS76_HUMAN shock 70 kda protein 6 (heat shock 70 K.ALRDAKLDKAQIHDVVLVGG.S 2 2.611 0.121 O (93%) kda protein b'). 2/1996 P52848 homo sapiens (human). heparan sulfate n-deacetylase/n- sulfotransferase (ec 2.8.2.-) (n- hsst) IPI:IPI00185657.1 SW:HSS1_HUMAN H.VSPQAVLFLLFIFCLFSVFI.S 2 3.210 0.135 P (n-heparan sulfate sulfotransferase) (96%) (glucosaminyl n- deacetylase/n- sulfotransferase). P01743 homo sapiens (human). ig IPI:IPI00217045.1 SW:HV1B_HUMAN heavy chain v-i region hg3 precursor. I.INPSGGSTSYAQK.F 2 2.263 0.165 G, O, P (99%) 7/1999 R.DTSTSTVYMELSSLR.S 1 2.434 0.275 2 4.060 0.447 P23083 homo sapiens (human). ig SW:HV1G_HUMA IPI:IPI00159843.1 heavy chain v-i region v35 precursor. A.PGQGLEWMGR.I 2 2.758 0.101 G N (92%) 7/1999 G.AHSQVQLVQSGAEVK.K 2 3.980 0.392 K.ASGYTFTGYYMHWVR.Q 2 2.543 0.100 N.TAYMELSSLR.S 1 2.048 0.212 2 3.065 0.250 R.DTSISTAYMEL.S 2 3.229 0.270 R.DTSISTAYMELSR.L 2 3.763 0.352 R.QAPGQGLEWMGR.I 2 2.942 0.095 T.STNTAYMELSSLR.S 2 3.431 0.338 W.INPNSGGTKYAQK.F 2 2.811 0.280 W.INPNSGGTNYAQK.F 1 2.346 0.210 2 2.788 0.325 P01814 homo sapiens (human). ig SW:HV2A_HUMAN K.ALEWLAR.I 1 1.873 0.141 G heavy chain v-ii region ou. 7/1999 Y.MDVWGK.G 1 1.833 0.122 Y.YYMDVWGK.G 1 2.275 0.093 Y.YYYMDVWGK.G 1 1.876 0.137 P01817 homo sapiens (human). ig SW:HV2D_HUMAN F.SLSTSGVGVGWIR.Q 2 3.148 0.322 G heavy chain v-ii region mce. 7/1999 P06331 homo sapiens (human). ig SW:HV2I_HUMAN heavy chain v-ii region arh-77 R.VTISLDTSK.N 1 2.058 0.183 G precursor. 7/1999 P01763 homo sapiens (human). ig SW:HV3B_HUMAN -.QVQLVDSGGGLVEPGGSLR.L 2 3.064 0.146 G, O heavy chain v-iii region wea. 7/1999 K.NSLYLQMSSLR.A 2 3.321 0.197 Q.LVDSGGGLVEPGGSLR.L 2 3.659 0.286 P01764 homo sapiens (human). ig SW:HV3C_HUMAN heavy chain v-iii region vh26 T.YYGDSVK.G 1 2.143 0.313 G precursor. 7/1999 SW:HV3G_HUMA P01768 homo sapiens (human). ig E.LVESGGGVVZPGR.S 1 2.301 0.150 G N heavy chain v-iii region cam. 7/1999 K.YYABSVKGR.F 1 1.864 0.154 P01769 homo sapiens (human). ig SW:HV3H_HUMAN Z.LVZSGGGAVZPGR.S 2 3.483 0.107 G, O heavy chain v-iii region ga. 7/1999 P01771 homo sapiens (human). ig SW:HV3J_HUMAN -.QVKLVQAGGGVVQPGR.S 2 4.110 0.304 G, O, P heavy chain v-iii region hil. 7/1999 P01772 homo sapiens (human). ig SW:HV3K_HUMAN K.NTLFLQMDSLR.V 2 3.179 0.317 G heavy chain v-iii region kol. 7/1999 Q.LVESGGGVVQPGR.S 1 2.604 0.231 2 4.113 0.202 P01777 homo sapiens (human). ig SW:HV3P_HUMAN -.EVQLVESGGGL.V 1 2.115 0.190 A, G, O, P heavy chain v-iii region tei. 7/1999 -.EVQLVESGGGLVQ.P 2 3.856 0.124 -.EVQLVESGGGLVQPGGSLR.L 1 4.113 0.177 2 5.805 1.000 3 4.484 0.162 E.SGGGLVQPGGSLR.L 2 3.028 0.236 K.NTLYLQM.N 1 2.005 0.182 K.NTLYLQMN.S 1 2.577 0.157 K.NTLYLQMNSLR.A 2 4.206 1.000 Q.LVESGGGLVQPGGSLR.L 1 3.104 0.206 Supplementary Table 1 241 2 4.467 0.228 R.YFDVWGQ.G 1 1.872 0.159 V.ESGGGLVQPGGSLR.L 1 3.108 0.388 2 2.768 0.212 P01779 homo sapiens (human). ig SW:HV3R_HUMAN -.EVQLLESGGGLVQPGGSLR.L 1 3.211 1.000 G heavy chain v-iii region tur. 7/1999 2 5.261 1.000 3 3.541 0.161 K.NTLYLQMLSLQ.A 2 2.658 1.000 Q.LLESGGGLVQPGGSLR.L 2 4.955 0.426 P01780 homo sapiens (human). ig SW:HV3S_HUMAN -.DVQLVESGGGLVKPGGSLR.L 2 4.887 0.388 G heavy chain v-iii region jon. 7/1999 E.SGGGLVKPGGSLR.L 1 2.119 0.243 2 2.765 0.156 L.ESGGGLVKPGGSLR.L 1 2.169 0.107 2 2.824 0.317 P01781 homo sapiens (human). ig SW:HV3T_HUMAN -.EVQLVESGGDLVQPGR.S 2 2.897 0.271 G, O heavy chain v-iii region gal. 7/1999 -.EVQLVESGGDLVQPGRSL.R 1 2.946 0.092 H.YVDSVK.R 1 1.927 0.115 K.GLEWVANIK.R 1 2.520 0.184 K.NSLFLQMNSLR.D 2 2.421 0.296 N.YYVDSVK.G 1 2.419 0.241 Q.LVESGGDLVQPGR.S 2 3.032 0.089 Z.BYVDSVK.G 1 1.913 0.080 P31314 homo sapiens (human). SW:HX11_HUMAN homeobox protein hox-11 (tcl-3 proto- S.LAQPLPADPLCVHNSSLF.A 1 2.146 0.178 G oncogene). 10/2001 O43711 homo sapiens (human). SW:HX1M_HUMA IPI:IPI00013824.2 homeobox protein hox-11l2 (t-cell F.QNRRTKWRRQTAEEREADGQ.Q 2 2.982 0.143 P N (92%) leukemia homeobox 3). 10/2001 Q00056 homo sapiens (human). SW:HXA4_HUMAN homeobox protein hox-a4 (hox-1d) A.TPGVPAGGSAPACPLLLADK.S 1 2.078 0.164 A (hox-1.4). 7/1999 P31268 homo sapiens (human). IPI:IPI00010743.1 SW:HXA7_HUMAN homeobox protein hox-a7 (hox-1a) A.KGACDKTDEGALHGAAEAN.F 2 3.447 0.091 P (94%) (hox 1.1). 10/2001 P14651 homo sapiens (human). A.EGCGGGGGGGGGGGSGGSGGGGGG SW:HXB3_HUMAN homeobox protein hox-b3 (hox-2g) 1 2.322 0.093 A, O GGGG.D (hox-2.7). 7/1999 A.QLVELEK.E 1 2.167 1.000 C.GGGGGGGGGGGSGGSGGGGGGGG 2 2.407 0.104 GGDK.S Q9gzz0 homo sapiens (human). A.YEPGAAPAAAAGGADYGFLGSGPAYD IPI:IPI00217854.1 SW:HXD1_HUMAN 2 2.628 0.165 G, P homeobox protein hox-d1. 10/2001 F.P (96%) Y.VSCSSSGGVGGDVLSLAPKFCRS.D 2 2.629 0.086 P13378 homo sapiens (human). SW:HXD8_HUMAN homeobox protein hox-d8 (hox-4e) A.ELVQYPDCKSSSGNIGE.D 1 2.207 0.152 G (hox-5.4). 10/2001 Q08334 homo sapiens (human). interleukin-10 receptor beta chain IPI:IPI00171871.1 SW:I10S_HUMAN A.FSPRNSLPQHLKEFLGHPHHNTLLF.F 2 2.709 0.108 A precursor (il-10r-b) (il-10r2) (cytokine (99%) receptor class-ii crf2-4). 10/2001 P17936 homo sapiens (human). insulin-like growth factor binding SW:IBP3_HUMAN K.YGQPLPGYTTK.G 2 2.398 0.235 P protein 3 precursor (igfbp-3) (ibp-3) (igf-binding protein 3). 10/2001 R.SAGSVESPSVSSTHR.V 2 3.259 0.358 P05155 homo sapiens (human). SW:IC1_HUMAN plasma protease c1 inhibitor precursor A.TSSSSQDPESLQDR.G 2 3.824 0.420 A, G, O, P (c1 inh) (c1inh). 10/2001 D.PDLQVSAMQHQTVLELTETGVEAAAA 3 4.531 0.438 SAISVAR.T F.SIASLLTQVLLGAGENTK.T 2 5.089 0.323 3 4.467 0.158 K.FQPTLLTLPR.I 2 2.818 0.323 K.GVTSVSQIFHSPDLAIR.D 2 4.492 0.448 3 3.541 0.338 K.HRLEDMEQALSPSVFK.A 2 4.822 0.393 3 4.714 0.333
Supplementary Table 1 242 K.KYPVAHFIDQTLK.A 2 4.012 0.323 K.LYHAFSAMK.K 1 2.503 0.246 2 2.430 0.178 K.NSVIKVPMMNSK.K 2 3.261 0.268 K.TNLESILSYPK.D 2 3.867 0.208 K.VTTSQDMLSIMEK.L 2 3.297 0.344 L.LLLLLAGDRASSNPNATSS.S 2 2.828 0.125 L.VLLNAIYLSAK.W 2 3.161 0.284 R.LEDMEQALSPSVFK.A 1 2.800 0.264 2 4.784 0.403 R.LLDSLPSDTR.L 2 3.253 0.153 R.LVLLNAIYLSAK.W 2 3.656 0.270 R.TLLVFEVQQPFLFVLWDQQHKFPVFM 3 4.552 0.316 GR.V R.TLYSSSPR.V 2 2.339 0.237 T.SSSSQDPESLQDR.G 2 3.201 0.399 O43837 homo sapiens (human). isocitrate dehydrogenase [nad] IPI:IPI00018499.1 SW:IDHB_HUMAN subunit beta, mitochondrial precursor I.ADAVKKVIKVG.K 2 2.796 0.180 O (95%) (ec 1.1.1.41) (isocitric dehydrogenase) (nad+-specific icdh). 10/2001 P46199 homo sapiens (human). translation initiation factor if-2, IPI:IPI00005039.1 SW:IF2M_HUMAN L.LDKFRKTQVAAVETGGITQHIGA.F 2 2.459 0.243 A, P mitochondrial precursor (if-2mt) (if- (97%) 2(mt)). 10/2001 V.ETGGITQHIGAFLV.S 2 2.786 0.101 V.RRPQADPALLTPRSPVVTIMGHVDHGK 3 3.874 0.153 TTLLDKFRKTQVA.A O75153 homo sapiens (human). putative eukaryotic translation IPI:IPI00024425.1 SW:IF3X_HUMAN V.RFPESCQDEVR.D 1 2.056 0.088 G initiation factor 3 subunit (eif-3) (95%) (fragment). 10/2001 Q14240 homo sapiens (human). IPI:IPI00029590.1 SW:IF42_HUMAN eukaryotic initiation factor 4a-ii (eif-4a- K.TATFAISILQQLEIEFK.E 1 2.714 0.128 A (97%) ii) (eif4a-ii). 10/2001 P09914 homo sapiens (human). interferon-induced protein with IPI:IPI00018300.1 SW:IFT1_HUMAN tetratricopeptide repeats 1 (ifit-1) R.RKALDLESLSLLGFVYKLE.G 2 3.167 0.120 P (94%) (interferon-induced 56 kda protein) (ifi- 56k). 10/2001 P78318 homo sapiens (human). immunoglobulin-binding protein 1 SW:IGB1_HUMAN (cd79a-binding protein 1) (b cell signal I.DISLEEIESID.Q 2 2.707 0.143 A, P transduction molecule alpha 4) (alpha 4 protein). 10/2001 R.QLLDEVEVATEPAGSRI.V 1 2.062 0.085 P01591 homo sapiens (human). SW:IGJ_HUMAN R.IIVPLNN.R 1 2.068 0.087 A, G, O, P immunoglobulin j chain. 10/2001 R.IIVPLNNR.E 1 2.429 0.115 R.IVLVDNK.C 1 2.434 0.092 R.SSEDPNEDIVER.N 2 3.619 0.096 P55103 homo sapiens (human). IPI:IPI00023314.1 SW:IHBC_HUMAN inhibin beta c chain precursor (activin A.VLNLLKANTAAGTTGGGSCC.V 2 2.771 0.156 G, O (96%) beta-c chain). 10/2001 A.VLNLLKANTAAGTTGGGSCCVPTARRP 2 2.534 0.123 .L P58166 homo sapiens (human). IPI:IPI00011036.1 SW:IHBE_HUMAN inhibin beta e chain precursor (activin R.TLLAEHHITNLGWHTLTLPSSGLR.G 3 3.695 0.356 P (91%) beta-e chain). 10/2001 Q13422 homo sapiens (human). dna- IPI:IPI00013232.1 SW:IKAR_HUMAN binding protein ikaros (lymphoid R.HIKLHSGEKPFKCHLC.N 2 2.550 0.112 O (98%) transcription factor lyf-1). 10/2001 O15111 h inhibitor of nuclear factor kappa-b kinase alpha subunit (ec 2.7.1.-) (i kappa-b kinase alpha) SW:IKKA_HUMAN I.VLQDVGGKIIHKIIDLGYAK.D 2 3.092 0.105 O, P (ikbka) (ikk-alpha) (ikk-a) (ikappab kinase) (i-kappa-b kinase 1) (ikk1) (conserved P20809 homo sapiens (human). interleukin-11 precursor (il-11) SW:IL11_HUMAN A.GALGALQLPGVLTRLRAD.L 1 2.105 0.081 G, P (adipogenesis inhibitory factor) (agif) (oprelvekin). 10/2001 D.GDHNLDSLPTLAMSAGALGALQL.P 2 2.579 0.105 Supplementary Table 1 243 P14778 homo sapiens (human). interleukin-1 receptor, type i precursor SW:IL1R_HUMAN E.KMPESIKFIKQK.H 2 2.512 0.123 A, G, O (il-1r-1) (il-1r-alpha) (p80) (antigen cd121a). 10/2001 R.LICFIALLISSLEADKCKEREEKIILV.S 3 3.738 0.124 Q01344 homo sapiens (human). interleukin-5 receptor alpha chain IPI:IPI00179688.1 SW:IL5R_HUMAN Q.INPPLNVTA.E 1 2.000 0.115 P precursor (il-5r-alpha) (cd125 antigen). (95%) 10/2001 P15814 homo sapiens (human). immunoglobulin lambda-like polypeptide 1 precursor IPI:IPI00027227.2 SW:ILL1_HUMAN K.YAASSYLSLTPEQWR.S 2 3.152 0.416 P (immunoglobulin- related 14.1 protein) (93%) (immunoglobulin omega polypeptide). 10/2001 O14925 homo sapiens (human). SW:IM23_HUMAN mitochondrial import inner membrane N.GLRLGLKETQNMAWSKPRNV.Q 2 2.674 0.132 A translocase subunit tim23. 10/2001 Q92973 homo sapiens (human). importin beta-2 subunit (karyopherin K.DFMIVALDLLSGLAEGLGGNIEQLVARS IPI:IPI00024364.1 SW:IMB2_HUMAN beta-2 subunit) (transportin) (m9 3 4.322 0.119 O NI.L (95%) region interaction protein) (mip). 10/2001 O00410 homo sapiens (human). importin beta-3 subunit (karyopherin C.GDTSLNNMQRQLALEVIVTLSETAAAM IPI:IPI00219204.1 SW:IMB3_HUMAN 3 3.780 0.155 A beta-3 subunit) (ran-binding protein 5). LRKHTNIV.A (99%) 10/2001 P20839 homo sapiens (human). inosine-5'-monophosphate IPI:IPI00180760.1 SW:IMD1_HUMAN dehydrogenase 1 (ec 1.1.1.205) (imp A.DGGIQTVGHVVKALALGASTVMMGS.L 2 2.651 0.129 O, P (99%) dehydrogenase 1) (impdh-i) (impd 1). 10/2001 T.EAPGEYFFSDGVR.L 1 2.178 0.110 P15260 homo sapiens (human). SW:INGR_HUMAN interferon-gamma receptor alpha I.PVVAALLLFLVLSLVFICFY.I 2 3.560 0.097 O chain precursor (cdw119). 10/2001 P40305 homo sapiens (human). SW:INI7_HUMAN interferon-alpha induced 11.5 kda A.SGSAVVLPLARIATV.V 2 3.525 0.214 O, P protein (p27). 2/1995 O95050 homo sapiens (human). indolethylamine n-methyltransferase (ec 2.1.1.49) (aromatic alkylamine n- SW:INMT_HUMAN K.REFSCVALEKEEV.E 2 3.139 0.126 O methyltransferase) (indolamine n- methyltransferase) (arylamine n- methyltransferase) ( Q14571 homo sapiens (human). inositol 1,4,5-trisphosphate-binding IPI:IPI00031545.1 SW:IP3S_HUMAN protein type 2 receptor (type 2 insp3 C.LLDKEGASELV.I 1 2.058 0.084 P (95%) receptor) (type 2 inositol 1,4,5- trisphosphate receptor). 10/2001 R.NQNNKTNYNLVCETLQ.F 1 2.318 0.133 P05154 homo sapiens (human). plasma serine protease inhibitor IPI:IPI00007221.1 SW:IPSP_HUMAN precursor (pci) (protein c inhibitor) K.AVVEVDESGTR.A 2 3.226 0.438 O, P (96%) (plasminogen activator inhibitor-3) (pai3). 7/1999 K.TLYLADTFPTNFR.D 2 2.664 0.193 P46940 homo sapiens (human). ras IPI:IPI00009342.1 SW:IQG1_HUMAN gtpase-activating-like protein iqgap1 N.VIQWLNAMDEIGLPKI.F 2 2.499 0.149 G, P (98%) (p195). 10/2001 T.SEQEAEHQRAMQR.R 1 1.902 0.221 Q13576 homo sapiens (human). ras IPI:IPI00220952.1 SW:IQG2_HUMAN gtpase-activating-like protein iqgap2. K.EIIDDKSLIINTNPVEVYKAWV.N 3 3.990 0.086 P (96%) 10/2001 O43187 homo sapiens (human). IPI:IPI00011228.1 SW:IRA2_HUMAN interleukin-1 receptor-associated V.RMATFPGPGSSPARAH.Q 1 2.528 0.122 A (94%) kinase-2 (ec 2.7.1.-) (irak-2). 10/2001 P10745 homo sapiens (human). interphotoreceptor retinoid-binding IPI:IPI00022337.1 SW:IRBP_HUMAN A.KVPTVLQTAGKLVADNYASAELGAK.M 3 3.726 0.137 A protein precursor (irbp) (interstitial (96%) retinol-binding protein). 10/2001 P21399 homo sapiens (human). iron- responsive element binding protein 1 IPI:IPI00008485.1 SW:IRE1_HUMAN (ire-bp 1) (iron regulatory protein 1) K.GPFLLGIKAVLAESYER.I 2 2.474 0.153 A, P (95%) (irp1) (ferritin repressor protein) (aconitate hydratase) (ec 4.2.1.3) Supplementary Table 1 244 (citrat P.VDEVSITYL.V 1 2.002 0.139 P14316 homo sapiens (human). IPI:IPI00026155.2 SW:IRF2_HUMAN interferon regulatory factor 2 (irf-2). P.DIEEVK.D 1 1.911 0.081 P (92%) 11/1997 R.ETRASVIKKTSDITQAR.V 2 3.128 0.140 Q15756 homo sapiens (human). IPI:IPI00019468.1 SW:IRKI_HUMAN inward rectifying k+ channel negative K.DLVENKFLLP.S 2 2.725 0.124 A (93%) regulator kir2.2v. 10/2001 P56199 homo sapiens (human). IPI:IPI00218908.1 SW:ITA1_HUMAN integrin alpha-1 (laminin and collagen R.DVAVVKVTMNFEPNKVNIQK.K 2 2.859 0.136 A (97%) receptor) (vla-1) (cd49a). 10/2001 P23229 homo sapiens (human). IPI:IPI00216225.1 SW:ITA6_HUMAN integrin alpha-6 precursor (vla-6) L.EAEKERRKSGLSSR.V 2 2.444 0.108 P (96%) (cd49f). 10/2001 R.PIPITASVE.I 1 1.878 0.152 Q13797 homo sapiens (human). IPI:IPI00015181.1 SW:ITA9_HUMAN integrin alpha-9 precursor (integrin L.ALGAVKNISLNISISNLGDDAYDAN.V 2 2.769 0.100 A, G (97%) alpha-rlc). 10/2001 L.SSMDEKTLYLALGAVKNISLNISISN.L 2 2.559 0.100 M.FSEIRDEGQVTV.Y 2 2.416 0.147 O75578 homo sapiens (human). IPI:IPI00026165.1 SW:ITAG_HUMAN I.GSVLGGLLLLALLVF.C 2 2.773 0.153 O integrin alpha-10 precursor. 10/2001 (91%) P20701 homo sapiens (human). integrin alpha-l precursor (leukocyte adhesion glycoprotein lfa-1 alpha IPI:IPI00217961.1 SW:ITAL_HUMAN I.FKAGHSVALQM.M 2 2.501 0.201 G, O, P chain) (leukocyte function associated (99%) molecule 1, alpha chain) (cd11a). 10/2001 L.VFLFDGSMSLQPD.E 1 2.437 0.200 P.LGRFGEAITALTDINGDGL.V 2 2.869 0.086 P19827 homo sapiens (human). inter- alpha-trypsin inhibitor heavy chain h1 precursor (iti heavy chain h1) (inter- IPI:IPI00001321.1 SW:ITH1_HUMAN A.AISGENAGLVR.A 2 3.457 0.358 A, G, O, P alpha-trypsin inhibitor complex (99%) component iii) (serum-derived hyaluronan-ass A.ISGENAGLVR.A 2 2.349 0.279 F.SLDEATNLNGGLLR.G 2 4.050 0.297 G.HMLENHVER.L 2 2.722 0.312 H.MLENHVER.L 2 3.021 0.276 H.VLFRPTVSQQQSCPTCSTSLLNGHFK. 3 5.289 0.352 V K.AAISGENAGLVR.A 1 1.993 0.179 2 4.155 0.357 K.DKVTAWK.Q 1 1.921 0.171 K.ELAAQTIKK.S 1 1.837 0.182 2 2.365 0.228 K.GHVLFRPTVSQQQSCPTCSTSLLNGH 3 5.509 0.446 FK.V K.GSLVQASEANLQAAQDFV.R 2 3.695 0.285 K.GSLVQASEANLQAAQDFVR.G 2 6.070 0.360 3 5.516 0.295 K.ILGDMQPGDYFDLVLFGTR.V 2 5.133 0.447 K.KGHVLFRPTVSQQQSCPTCSTSLLNG 3 3.835 0.331 HFK.V K.LDAQASFLPK.E 2 4.128 0.349 K.PLLVDVDLQYPQDAVLALTQNHHK.Q 3 5.627 0.440 K.QLVHHFEIDVDIFEPQGISK.L 3 4.376 0.318 K.QYYEGSEIVVAGR.I 2 4.126 0.405 K.RQAVDTAVDGVFIR.S 2 3.291 0.396 K.TAFISDFAVTADGNAFIGDIK.D 2 5.892 0.518 M.LENHVER.L 2 2.444 0.181 M.LTDGDPTEGVTDR.S 2 3.324 0.331 M.SLDYGFVTPLTSMSIR.G 2 3.662 0.450 Q.MSLDYGFVTPLTSMSIR.G 2 4.229 0.400 R.ERGHMLENHVER.L 3 4.469 0.273 R.EVAFDLEIPK.T 2 3.143 0.213 R.FAHYVVTSQVVNTANEAR.E 2 6.865 0.448
Supplementary Table 1 245 3 4.848 0.271 R.GFSLDEATNLNGGLL.R 2 3.583 0.089 R.GFSLDEATNLNGGLLR.G 2 4.281 0.385 R.GHMLENHVER.L 1 2.420 0.228 2 3.457 0.353 R.GIEILNQVQESLPELSNHA.S 2 3.068 0.297 R.GIEILNQVQESLPELSNHAS.I 2 3.806 0.256 R.GIEILNQVQESLPELSNHASILIMLTDGD 3 5.564 0.378 PTEGVTDR.S R.GMADQDGLKPTIDKPSEDSPPLEM.L 2 3.274 0.114 R.GMADQDGLKPTIDKPSEDSPPLEMLG 2 3.015 0.238 PR.R 3 5.659 0.360 R.GRFPLYNLGFGH.N 2 4.327 0.371 R.GRFPLYNLGFGHN.V 2 3.275 0.349 R.GRFPLYNLGFGHNVDFNFLEVMSMEN 3 4.944 0.380 NGR.A R.IADNKQSSFK.A 2 3.136 0.335 R.IYEDHDATQQLQGFYSQVAK.P 2 5.911 0.444 3 5.027 0.262 R.KAAISGENAGLVR.A 2 4.402 0.377 R.LWAYLTIQELLAK.R 2 4.733 0.335 R.NHMQYEIVIK.V 2 3.216 0.420 R.PTVSQQQSCPTCSTSLLNGHFK.V 3 3.768 0.319 R.QAVDTAVDGVFIR.S 2 3.878 0.341 R.RTFVLSALQPSPTHSSSNTQR.L 2 2.885 0.259 R.VTGVDTD.P 1 1.852 0.097 S.ILIMLTDGDPTEGVTDR.S 2 5.052 0.439 T.SQVVNTANEAR.E 2 3.136 0.327 V.DLQYPQDAVLALTQNHHK.Q 2 2.907 0.255 W.AYLTIQELLAK.R 2 3.581 0.111 Y.LVSLLILQAMPALGSATGRSKSSEK.R 3 3.896 0.154 Y.VVTSQVVNTANEAR.E 2 3.001 0.349 P19823 homo sapiens (human). inter- alpha-trypsin inhibitor heavy chain h2 precursor (iti heavy chain h2) (inter- IPI:IPI00021002.1 SW:ITH2_HUMAN A.HVSFKPTVAQQR.I 2 2.878 0.281 A, G, O, P alpha-trypsin inhibitor complex (98%) component ii) (serum-derived hyaluronan-asso A.YLTINQLLAER.S 2 2.890 0.208 F.YNQVSTPLLR.N 2 2.765 0.262 H.HIVTPLTSLVIENEAGDER.M 2 3.104 0.263 I.QPSGGTNINEALLR.A 2 2.819 0.364 I.YGNQDTSSQLK.K 2 3.562 0.332 I.YGNQDTSSQLKK.F 2 3.376 0.272 K.AGELEVFNGYFVHFFAPDNLDPIPK.N 3 4.940 0.407 K.AHVSFKPTVAQ.Q 2 2.506 0.302 K.AHVSFKPTVAQQ.R 2 2.523 0.292 K.AHVSFKPTVAQQR.I 1 2.980 0.295 2 3.772 0.262 K.DKHADPDFTR.K 1 2.273 0.190 2 2.581 0.261 K.ENIQDNISLFSL.G 2 3.242 0.183 K.FDPAKLDQIESVITATSANTQLVLETLA 3 4.509 0.382 QMDDLQDFLSK.D K.FYNQVSTPLL.R 1 1.895 0.137 2 2.939 0.163 K.FYNQVSTPLLR.N 1 1.902 0.150 2 3.608 0.353 K.HADPDFTR.K 2 2.618 0.226 K.HLEVDVWVIEPQGLR.F 2 5.305 0.366 3 3.989 0.100 K.IQPSGGTNINEA.L 2 4.236 0.247 K.IQPSGGTNINEALLR.A 2 4.027 0.346 K.KFYNQVSTPLLR.N 2 3.752 0.333 K.LDQIESVITATSANTQLVLETLAQMDDL 3 5.930 0.443 Supplementary Table 1 246 QDFLSK.D K.MKQTVEAMK.T 2 3.169 0.193 K.NVKENIQDNISLFSLGMGFDVDYDFLK 3 6.610 0.445 R.L K.RLSNENHGIAQR.I 2 4.304 0.361 3 3.566 0.222 K.TAGLVR.S 1 1.816 0.149 K.TILDDLRAEDHFSVIDFNQNIR.T 2 3.045 0.262 3 5.029 0.371 K.VQFELHYQEVK.W 1 1.953 0.226 2 3.968 0.207 K.VVNNSPQPQNVVFDVQIPK.G 2 5.274 0.379 3 5.457 0.310 L.SNENHGIAQR.I 2 3.917 0.276 M.SLDHHIVTPLTSLVIENEAGDER.M 2 4.531 0.347 3 5.093 0.399 N.NSPQPQNVVFDVQIPK.G 2 3.215 0.436 N.SPQPQNVVFDVQIPK.G 2 3.274 0.315 N.TQLVLETLAQMDDLQDFLSK.D 2 4.352 0.331 Q.PSGGTNINEALLR.A 1 2.687 0.229 R.AEDHFSVIDFNQNIR.T 2 4.539 0.400 3 4.185 0.194 R.ETAVDGELVVLYDVK.R 2 4.970 0.551 R.FLHVPDTFEGHFDGVPVISK.G 2 4.907 0.384 3 4.130 0.234 R.IYGNQDTSSQLK.K 1 2.489 0.299 2 3.855 0.300 R.IYGNQDTSSQLKK.F 1 2.724 0.182 2 4.314 0.406 R.KLGSYEHR.I 2 2.695 0.209 R.KLWAYLTINQLLAER.S 2 5.105 0.400 R.LSNENHGIAQ.R 2 2.903 0.254 R.LSNENHGIAQR.I 1 2.779 0.211 2 3.949 0.282 R.MATTMIQSK.V 1 2.106 0.174 2 2.857 0.223 R.MLADAPPQDPSCCSGALYYGSK.V 2 2.933 0.259 R.NDLISATK.T 1 2.210 0.142 2 2.751 0.124 R.NVQFNYPHTSVTDVTQNNFHNYFGGS 3 5.508 0.352 EIVVAGK.F R.SILQMSLDHHIVTPLTSLVIENEAGDER. 2 3.361 0.312 M 3 7.931 0.476 R.SLPGESEEMMEEVDQVTLYSYK.V 2 4.716 0.509 R.SSALDMENFR.T 2 3.137 0.244 R.TEVNVLPGAK.V 1 2.414 0.237 2 2.931 0.220 R.TWRNDLISATK.T 2 3.430 0.174 S.LVIENEAGDER.M 2 2.959 0.159 T.SANTQLVLETLAQMDDLQDFLSK.D 2 4.002 0.406 V.SLIILVSDGDPTVGELK.L 2 3.151 0.367 Y.NQVSTPLLR.N 2 2.254 0.108 Q06033 homo sapiens (human). inter- alpha-trypsin inhibitor heavy chain h3 IPI:IPI00028413.1 SW:ITH3_HUMAN precursor (iti heavy chain h3) (serum- A.HNVVTMR.A 2 2.432 0.151 A, O, P (98%) derived hyaluronan-associated protein) (shap). 10/2001 F.AHNVVTMR.A 2 2.527 0.237 K.EHLVQATPENLQEA.K 2 2.614 0.148 K.EHLVQATPENLQEAR.T 2 4.586 0.360 K.EVSFDVELPK.T 2 2.419 0.206 K.FPLYNLGFGNNLNYNFLENMALENHGF 3 4.808 0.307 AR.R K.GHVSFKPSLDQQR.S 2 3.709 0.320
Supplementary Table 1 247 K.VSDIRPGSDPTKPDATLVVK.N 3 3.588 0.218 K.YHFVTPLTSMVVTKPEDNEDER.A 2 4.362 0.456 3 4.924 0.462 L.TSMVVTKPEDNEDER.A 2 4.020 0.444 M.LTDGDANVGESRPEK.I 2 3.027 0.188 M.VVTKPEDNEDER.A 2 2.674 0.211 R.ALDLSLK.Y 1 1.846 0.089 R.DYIFGNYIER.L 1 2.371 0.235 2 2.688 0.278 R.FAHNVVTMR.A 2 2.576 0.362 R.LVDEDMNSFK.A 2 3.037 0.366 R.NAIGGKFPLYNLGFGNNLNYNFLENMA 3 3.640 0.259 LENHGFAR.R R.SLPEGVANGIEVYSTK.I 2 3.461 0.471 R.STSIVIMLTDGDANVGESRPEK.I 2 3.748 0.307 V.TTEKITCGTGRASTFS.W 1 2.269 0.090 Q14624 h inter-alpha-trypsin inhibitor heavy chain h4 precursor (iti heavy IPI:IPI00032194.1 SW:ITH4_HUMAN chain h4) (inter-alpha-trypsin inhibitor A.EAQAQYSAAVAK.G 2 3.241 0.369 A, G, O, P (96%) family heavy chain-related protein) (ihrp) (plasma kallikrein sensitive A.EKNGIDIYSLTVDSR.V 2 3.661 0.373 F.AHTVVTSR.V 1 1.911 0.145 F.KPTLSQQQK.S 1 2.282 0.131 2 2.345 0.175 F.SMNIDGMTYPGIIK.E 2 4.426 0.354 H.YFAPEGLTTMPK.N 2 2.367 0.145 K.AEAQAQYSAAVAK.G 1 2.944 0.300 2 5.126 0.367 K.AFITNFSMNIDGMTYPGIIK.E 2 2.348 0.229 K.EKAEAQAQYSAAVAK.G 2 4.554 0.383 K.IEETTMTTQTPAPIQAPSAILPLPGQSV 2 2.517 0.236 ER.L K.IPKPEASFSPR.R 2 2.213 0.269 K.ITFELVYEELLK.R 2 4.589 0.332 K.SPEQQETVLDGNLIIR.Y 2 5.384 0.440 3 4.546 0.193 K.VRPQQLVK.H 2 2.459 0.147 K.YYLQGAK.I 1 2.137 0.114 P.EQQETVLDGNLIIR.Y 2 3.517 0.324 P.KPEASFSPR.R 2 2.436 0.246 R.AISGGSIQIENGYFVHYFAPEGL.T 2 2.719 0.135 R.AISGGSIQIENGYFVHYFAPEGLTTMPK 2 2.700 0.358 .N 3 4.764 0.439 R.ANTVQEATFQMELPK.K 1 2.739 0.179 2 4.501 0.328 R.ANTVQEATFQMELPKK.A 2 2.887 0.324 R.FAHTVVTSR.V 1 2.179 0.244 2 2.661 0.287 R.FKPTLSQQQK.S 2 2.854 0.135 R.LGVYELLLK.V 2 3.165 0.229 R.NMEQFQVSVSVAPNAK.I 2 4.252 0.438 R.NVHSGSTFFK.Y 1 3.285 0.288 2 2.402 0.162 R.RLGVYELLLK.V 2 2.983 0.113 R.VSSRFAHTVVTSR.V 2 2.582 0.258 V.RPQQLVK.H 1 1.807 0.189 P26440 homo sapiens (human). isovaleryl-coa dehydrogenase, I.PYLHVREAFGQKIGHFQLMQGKMADM SW:IVD_HUMAN 3 4.172 0.166 P mitochondrial precursor (ec 1.3.99.10) YTRLMA.C (ivd). 10/2001 Q92833 homo sapiens (human). IPI:IPI00023756.1 SW:JMJ_HUMAN H.QAEKPQSPPKKMKGA.A 2 2.556 0.136 A, O jumonji protein. 10/2001 (92%) R.REQASANHPAAAPSTGSSAKGL.A 2 2.675 0.135 P35527 homo sapiens (human). IPI:IPI00019359.1 SW:K1CI_HUMAN E.INVAPGKDLTK.T 2 2.516 0.169 A, G, O, P keratin, type i cytoskeletal 9 (96%) Supplementary Table 1 248 (cytokeratin 9) (k9) (ck 9). 10/2001 G.FGGGFGGGSGGGFGGGYGSGFGGL 2 2.768 0.114 GGF.G H.SGGSGGGHSGGSGGNYGGGSGSGG 3 7.187 0.492 GSGGGYGGGSGSR.G H.SGGSGGNYGGGSGSGGGSGGGYGG 2 5.614 0.514 GSGSR.G K.DIENQYETQITQIEHEVSSSGQEVQSSA 2 3.700 0.440 K.E 3 5.921 0.438 K.EIETYHNLLEGGQEDFESSGAGK.I 2 5.135 0.359 3 4.673 0.246 K.IGLGGRGGSGGSYGR.G 2 3.172 0.324 K.NHKEEMSQLTGQNSGDVNVEINVAPG 3 4.144 0.129 KDLTK.T K.NYSPYYNTIDDLKDQIVDLTVGNNK.T 2 2.764 0.249 3 3.908 0.368 K.NYSPYYNTIDDLKDQIVDLTVGNNKTLL 3 5.919 0.441 DIDNTR.M K.STMQELNSR.L 2 2.442 0.104 K.TLLDIDNTR.M 1 2.067 0.241 K.TLNDMRQEYEQLIAK.N 2 3.621 0.263 K.VQALEEANNDLENK.I 1 2.984 0.230 2 5.383 0.376 Q.IEHEVSSSGQEVQSSAK.E 2 5.092 0.475 3 4.115 0.295 Q.LASYLDK.V 1 1.957 0.227 Q.LASYLDKVQALEEANNDLENK.I 2 4.702 0.442 3 5.027 0.323 Q.LASYLDKVQALEEANNDLENKIQDWYD 3 3.915 0.156 KK.G R.FSSSSGYGGGSSR.V 2 3.358 0.391 R.GGGGSFGYSYGGGSGGGFSASSLGG 2 5.239 0.588 GFGGGSR.G 3 4.320 0.376 R.GGSGGSHGGGSGFGGE.S 2 3.629 0.360 R.GGSGGSHGGGSGFGGESGGSYGGG 2 5.931 0.604 EEA.S R.GGSGGSHGGGSGFGGESGGSYGGG 2 4.743 0.489 EEASGSGGGYGGGSGK.S 3 7.003 0.541 R.GGSGGSHGGGSGFGGESGGSYGGG 3 6.486 0.502 EEASGSGGGYGGGSGKSSHS.- R.GGSGGSYGGGGSGGGYGGGSGSR.G 1 3.196 0.303 2 5.603 0.445 R.GGSGGSYGGGGSGGGYGGGSGSRG. 2 4.115 0.312 G R.GGSGGSYGGGSGSGGGSGGGYGGG 2 4.931 0.562 SGGGH.S R.GGSGGSYGGGSGSGGGSGGGYGGG 3 4.152 0.478 SGGGHSGGSGGGH.S R.GGSGGSYGGGSGSGGGSGGGYGGG SGGGHSGGSGGGHSGGSGGNYGGGS 3 5.245 0.324 GSGGGSGGGYGGGSGSR.G R.GSRGGSGGSYGGGGSGGGYGGGSG 2 7.502 0.262 SR.G 3 5.557 0.241 R.HGVQELEIELQSQLSK.K 2 5.208 0.390 3 3.710 0.162 R.IKFEMEQNLR.Q 2 2.572 0.185 R.KDIENQYETQITQIEHEVSSSGQEVQS 3 4.773 0.251 SAK.E R.QEYEQLIAK.N 2 2.392 0.100 R.QGVDADINGLR.Q 2 3.333 0.296 R.QVLDNLTMEK.S 2 2.666 0.165 T.SGGGGGGGLGSGGSIR.S 1 1.901 0.135 2 4.190 0.449 W.YDKKGPAAIQK.N 2 3.075 0.283 Y.SYGGGSGGGFSASSLGGGFGGGSR.G 2 3.580 0.418
Supplementary Table 1 249 P13645 homo sapiens (human). SW:K1CJ_HUMAN keratin, type i cytoskeletal 10 K.DAEAWFNEK.S 1 2.705 0.175 A, G, O, P (cytokeratin 10) (k10) (ck 10). 10/2001 2 2.875 0.254 K.ELTTEIDNNIEQISSYK.S 2 3.875 0.333 K.GSLGGGFSSGGFSGGSFSR.G 2 5.238 0.465 K.IRLENEIQTYR.S 2 4.114 0.323 K.QSLEASLAETEGR.Y 2 2.682 0.299 K.SKELTTEIDNNIEQISSYK.S 2 2.291 0.211 K.SSSSGSVGESSSKGP.R 1 2.828 0.302 2 2.992 0.262 K.SSSSGSVGESSSKGPR.Y 2 3.472 0.355 K.TIDDLKNQILNLTTDNANILLQIDNAR.L 3 4.270 0.255 L.GGGFSSGGFSGGSFSR.G 2 3.118 0.383 R.ALEESNYELEGK.I 1 2.318 0.222 2 4.165 0.361 R.GGGSFGGGYGGGSSGGGSSGGGHG 2 3.725 0.458 G.S R.KDAEAWFNEK.S 2 2.746 0.205 R.LENEIQTYR.S 1 2.983 0.153 2 4.119 0.312 R.LKYENEVALR.Q 2 3.212 0.250 R.NVSTGDVNVEMNAAPGVDLTQLLNNM 2 2.690 0.290 R.S 3 4.001 0.163 R.SGGRGGGSFGGGYGGGTSGGGTSG 3 3.862 0.195 GGYGGGHGGSSGGGYG.G R.SLLEGEGSSGGGGR.G 1 2.230 0.131 2 3.700 0.353 R.SQYEQLAEQNR.K 1 2.684 0.262 2 4.686 0.324 R.SQYEQLAEQNRK.D 1 1.932 0.096 2 3.251 0.164 P13646 homo sapiens (human). SW:K1CM_HUMA IPI:IPI00171196.1 keratin, type i cytoskeletal 13 K.VLDDLTMTRS.D 1 1.881 0.153 A, G N (95%) (cytokeratin 13) (k13) (ck 13). 10/2001 R.QSVEADINGLR.K 2 2.764 0.295 Q04695 homo sapiens (human). SW:K1CQ_HUMA keratin, type i cytoskeletal 17 IPI:IPI00174822.1 R.APSTYGGGLSVSSSR.F 2 3.397 0.414 A, G, P N (cytokeratin 17) (k17) (ck 17) (39.1) (92%) (version 1). 10/2001 R.EVATNSELVQSGK.S 2 3.891 0.422 P08779 homo sapiens (human). keratin, type i cytoskeletal 17 K.TEELNKEVASNSELVQSSRSEVTELRR. IPI:IPI00174844.1 SW:K1CX_HUMAN 3 3.667 0.095 A, G, P (cytokeratin 17) (k17) (ck 17) (version V (93%) 2). 10/2001 K.VTMQNLNDR.L 2 3.175 0.230 Q14525 homo sapiens (human). SW:K1MB_HUMA IPI:IPI00031423.1 keratin, type i cuticular ha3-ii (hair E.VDAAPAVDLNQVLNETRNQY.E 2 3.521 0.094 G N (92%) keratin, type i ha3-ii). 10/2001 P35908 homo sapiens (human). keratin, type ii cytoskeletal 2 K.AAFGGSGGRGSSSGGGYSSGSSSYG IPI:IPI00021304.1 SW:K22E_HUMAN 2 4.564 0.465 A, G, P epidermal (cytokeratin 2e) (k2e) (ck SGGR.Q (94%) 2e). 10/2001 3 4.710 0.365 K.DVDNAYMIK.V 2 2.315 0.226 K.EEAEALYHSK.Y 2 2.886 0.353 K.GGSISGGGYGSGGGK.H 2 2.682 0.279 K.HSSGGGSRGGSSSGGGYGSGGGGSS 2 3.135 0.374 SVK.G 3 4.425 0.290 R.FGGFGGPGGVGGLGGPGGFGPGGYP 3 5.394 0.426 GGIHEVSVNQSLLQPLNVK.V R.GEHALKDAR.N 1 2.449 0.214 R.GFSSGSAVVSGGSR.R 1 2.439 0.302 2 4.522 0.364 R.GGSGGGGSISGGGYGSGGGSGGR.Y 2 4.905 0.573 R.GGSSSGGGYGSGGGGSSSVK.G 1 3.058 0.432 2 4.562 0.464 Supplementary Table 1 250 R.GSSSGGGYSSGSSSYGSGGR.Q 2 4.505 0.510 R.HGGGGGGFGGGGFGSR.S 1 3.264 0.312 2 4.837 0.424 R.SKEEAEALYHSK.Y 1 2.272 0.279 2 3.659 0.398 R.TSQNSELNNMQDLVEDYK.K 2 2.397 0.330 P04264 homo sapiens (human). keratin, type ii cytoskeletal 1 SW:K2C1_HUMAN (cytokeratin 1) (k1) (ck 1) (67 kda D.PEIQKVKSR.E 2 3.098 0.193 A, G, O, P cytokeratin) (hair alpha protein). 10/2001 F.LEQQNQVLQTK.W 2 3.835 0.296 K.AEAESLYQSK.Y 1 2.273 0.162 2 3.555 0.298 K.AEAESLYQSKYEELQITAGR.H 2 4.244 0.377 K.AQYEDIAQK.S 1 2.612 0.181 2 2.290 0.229 K.DVDGAYMTK.V 1 2.138 0.204 K.LNDLEDALQQAK.E 2 4.496 0.303 K.NKLNDLEDALQQAK.E 2 4.437 0.311 K.NKLNDLEDALQQAKEDLAR.L 3 4.954 0.355 K.NMQDMVEDYR.N 2 3.452 0.422 K.QISNLQQSISDAEQR.G 2 4.213 0.426 K.SKAEAESLYQSK.Y 1 3.285 0.180 2 4.313 0.310 K.SKAEAESLYQSKYEELQITAGR.H 2 5.203 0.464 3 5.203 0.525 K.SLNNQFASFIDK.V 1 2.949 0.233 2 4.072 0.420 K.SLNNQFASFIDKVR.F 2 3.863 0.462 K.WELLQQVDTSTR.T 2 4.068 0.303 K.YEELQITAGR.H 1 1.965 0.086 2 3.712 0.291 L.NVEIDPEIQK.V 1 2.636 0.243 N.KYEDEINKR.T 1 1.978 0.209 2 2.696 0.129 Q.FASFIDKVR.F 2 2.708 0.159 R.DYQELMNTK.L 2 2.950 0.290 R.EREQIKSLNNQFASFIDKVR.F 3 4.221 0.434 R.FLEQQNQVLQTK.W 1 2.814 0.212 2 4.866 0.212 R.FLEQQNQVLQTKWELLQQVDTSTR.T 3 6.667 0.448 R.GGGGGGYGSGGSSYGSGGGSYGSG 2 5.801 0.302 GGGGGGR.G 3 6.329 0.294 R.GGSGGGGGGSSGGRGSGGGSSGGSI 2 4.276 0.414 GGR.G R.GSGGGSSGGSIGGR.G 2 3.867 0.415 R.GSYGSGGSSYGSGGGSYGSGGGGG 2 3.973 0.430 GHGSYGSGSSSGGYR.G 3 5.327 0.304 R.LRSEIDNVK.K 2 2.778 0.188 R.LRSEIDNVKK.Q 2 2.601 0.189 R.LRSEIDNVKKQISNLQQSISDAEQR.G 3 4.277 0.408 R.NKYEDEINK.R 2 2.996 0.153 R.NKYEDEINKR.T 1 2.137 0.080 2 3.145 0.248 R.RVDQLKSDQSR.L 2 3.161 0.317 R.SGGGFSSGSAGIINYQR.R 2 3.201 0.355 R.SLDLDSIIAEVK.A 1 3.144 0.252 2 4.498 0.319 R.SLDLDSIIAEVKAQYEDIAQK.S 2 4.883 0.347 3 4.821 0.420 R.SLVNLGGSK.S 1 1.888 0.259 R.SLVNLGGSKSISISVAR.G 2 3.478 0.375
Supplementary Table 1 251 R.THNLEPYFESFINNLR.R 1 2.063 0.109 2 3.696 0.351 3 4.949 0.241 R.TNAENEFVTIK.K 2 3.617 0.253 R.TNAENEFVTIKK.D 2 3.701 0.358 R.VDQLKSDQSR.L 2 2.443 0.224 S.KAEAESLYQSKYEELQITAGR.H 2 2.283 0.136 S.SYGSGGGSYGSGGGGGGHGSYGSG 2 3.362 0.191 SSSGGYRG.G S.VSTSHTTISGGGSR.G 1 2.622 0.314 2 3.210 0.348 S.VSVSTSHTTISGGGSR.G 2 3.573 0.387 W.ELLQQVDTSTR.T 2 2.401 0.135 P12035 homo sapiens (human). keratin, type ii cytoskeletal 3 SW:K2C3_HUMAN R.SLDLDSIIAEVGA.Q 1 2.819 0.283 A, G (cytokeratin 3) (k3) (ck3) (65 kda cytokeratin). 10/2001 2 3.768 0.280 P19013 homo sapiens (human). K.VDSLNDEINFLKVLYDAELSQMQTHVS SW:K2C4_HUMAN keratin, type ii cytoskeletal 4 3 3.575 0.168 A, G, P DTSVVLSM.D (cytokeratin 4) (k4) (ck4). 10/2001 R.AQYEEIAQR.S 1 2.124 0.135 2 3.025 0.231 R.NLDLDSIIAEVR.A 2 2.613 0.165 W.FLEQQNKVLETK.W 2 3.572 0.087 P13647 homo sapiens (human). keratin, type ii cytoskeletal 5 SW:K2C5_HUMAN G.GGLSVGGSGFSASSSR.G 2 2.370 0.192 A, G, O (cytokeratin 5) (k5) (ck 5) (58 kda cytokeratin). 10/2001 G.LGVGFGSGGGSSSSVK.F 2 2.718 0.207 K.WTLLQEQGTK.T 1 2.097 0.142 K.YEELQQTAGR.H 1 2.037 0.162 2 2.745 0.110 R.NLDLDSIIAEVK.A 1 2.664 0.322 2 4.487 0.267 R.NLDLDSIIAEVKAQYEEIAQR.S 2 3.794 0.271 R.SRTEAESWYQTK.Y 2 2.947 0.306 P08729 homo sapiens (human). SW:K2C7_HUMAN keratin, type ii cytoskeletal 7 K.LALDIEIATYR.K 2 3.258 0.225 P (cytokeratin 7) (k7) (ck 7). 10/2001 Q9uk32 homo sapiens (human). ribosomal protein s6 kinase alpha 6 (ec 2.7.1.-) (s6k-alpha 6) (90 kda IPI:IPI00007123.1 SW:K6A6_HUMAN A.TSIAEEYKITPITSANVLPIVQ.I 2 2.623 0.092 G ribosomal protein s6 kinase 6) (p90- (98%) rsk 6) (ribosomal s6 kinase 4) (rsk-4) (pp90rsk4). 1 P08237 homo sapiens (human). 6- phosphofructokinase, muscle type (ec IPI:IPI00181260.1 SW:K6PF_HUMAN 2.7.1.11) (phosphofructokinase 1) M.NNWEVYK.L 1 2.127 0.107 A (98%) (phosphohexokinase) (phosphofructo- 1-kinase isozyme a) (pfk-a). 10/2001 Q01813 homo sapiens (human). 6- phosphofructokinase, type c (ec 2.7.1.11) (phosphofructokinase 1) SW:K6PP_HUMAN K.YAYLNVVGMVGSIDNDFCGTDMTI.G 2 2.518 0.082 G, P (phosphohexokinase) (phosphofructo- 1-kinase isozyme c) (pfk-c) (6- phosphofructokinase, plat N.FGTKISARAMEWITAK.L 1 2.684 0.085 P01834 homo sapiens (human). ig SW:KAC_HUMAN -.DIQMTQSPASLSVSV.G 2 3.084 0.103 A, G, O, P kappa chain c region. 10/2001 A.DYEKHKVYACEVTHQGLSSPVTK.S 2 2.264 0.142 A.LQSGNSQESVTEQD.S 2 3.929 0.299 A.LQSGNSQESVTEQDSK.D 1 2.737 0.241 2 4.241 0.401 C.EVTHQGLSSPVTK.S 1 3.104 0.264 2 4.064 0.392 D.NALQSGNSQESVTEQDSK.D 2 5.363 0.539 E.SVTEQDSK.D 1 2.090 0.222 E.SVTEQDSKDSTYSLSSTLTLSK.A 2 2.611 0.259 E.VTHQGLSSPVTK.S 1 3.224 0.231 Supplementary Table 1 252 2 3.425 0.426 F.IFPPSDEQLK.S 1 2.319 0.111 F.PPSDEQLK.S 1 2.439 0.161 G.NSQESVTEQDSK.D 2 4.303 0.379 H.KVYACEVTHQGLSSPVTK.S 2 2.713 0.163 I.FPPSDEQLK.S 1 2.576 0.160 K.DSTYSLSSTL.T 1 1.984 0.111 K.DSTYSLSSTLTL.S 1 2.297 0.103 2 4.491 0.361 K.DSTYSLSSTLTLSK.A 1 3.714 0.345 2 4.095 0.388 K.HKVYACEVTHQGLSSPVTK.S 3 4.144 0.371 K.RADAAPTVFIFPPSDEQLK.S 3 3.750 0.091 K.SGTASVVCLLNNFYPR.E 1 2.393 0.123 2 3.640 0.386 K.VDNALQSGN.S 1 1.957 0.139 K.VDNALQSGNSQ.E 1 2.476 0.082 2 3.688 0.226 K.VDNALQSGNSQE.S 1 2.737 0.278 2 4.185 0.251 K.VDNALQSGNSQES.V 1 2.492 0.137 2 4.309 0.317 K.VDNALQSGNSQESVT.E 2 2.851 0.258 K.VDNALQSGNSQESVTEQ.D 2 4.030 0.378 K.VDNALQSGNSQESVTEQD.S 1 3.673 0.278 2 5.600 0.367 K.VDNALQSGNSQESVTEQDSK.D 2 6.269 0.485 3 5.213 0.374 K.VDNALQSGNSQESVTEQDSKD.S 2 4.576 0.428 K.VDNALQSGNSQESVTEQDSKDSTY.S 2 3.879 0.409 K.VDNALQSGNSQESVTEQDSKDSTYSL 2 3.286 0.266 S.S 3 3.505 0.152 K.VDNALQSGNSQESVTEQDSKDSTYSL 2 3.840 0.402 SSTLTLSK.A 3 5.808 0.459 K.VQWKVDNALQSGNSQESVTEQD.S 2 2.988 0.322 K.VQWKVDNALQSGNSQESVTEQDSK.D 2 4.719 0.373 3 5.359 0.451 K.VQWKVDNALQSGNSQESVTEQDSKD. 3 4.377 0.339 S K.VQWKVDNALQSGNSQESVTEQDSKD 3 5.647 0.394 STYSLSSTLTLSK.A K.VYACEVTHQGL.S 2 2.871 0.405 K.VYACEVTHQGLSSPVTK.S 2 5.125 0.494 L.QSGNSQESVTEQD.S 2 3.595 0.144 L.QSGNSQESVTEQDSK.D 1 2.452 0.334 2 4.135 0.447 N.ALQSGNSQESVTEQ.D 2 3.895 0.393 N.ALQSGNSQESVTEQD.S 2 4.828 0.276 N.ALQSGNSQESVTEQDSK.D 1 3.292 0.420 2 5.537 0.475 3 4.028 0.355 N.LAWYQQK.Q 1 2.224 1.000 N.SQESVTEQDSK.D 1 2.394 0.189 2 3.695 0.322 N.SQESVTEQDSKDSTYSLSSTLTLSK.A 2 2.756 0.380 P.PSDEQLK.S 1 2.040 0.140 Q.ESVTEQDSK.D 1 1.915 0.270 Q.ESVTEQDSKDSTYSLSSTLTLSK.A 2 2.304 0.156 Q.SGNSQESVTEQD.S 2 3.266 0.274 Q.SGNSQESVTEQDSK.D 1 2.988 0.394 2 4.863 0.430 Q.SGNSQESVTEQDSKDSTYSLSSTLTLS 2 3.378 0.267 K.A Supplementary Table 1 253 R.ADAAPTVFIFPPSDEQLK.S 2 3.131 0.319 S.GNSQESVTEQD.S 2 3.733 0.314 S.GNSQESVTEQDSK.D 1 2.274 0.316 2 3.795 0.269 S.KADYEKHKVYACEVTHQGLSSPVTK.S 3 3.551 0.227 S.NLAWYQQK.Q 1 2.184 0.215 T.HQGLSSPVTK.S 1 2.770 0.334 T.VFIFPPSDEQLK.S 1 2.661 0.164 2 3.080 0.163 V.DNALQSGNSQESVTEQDSK.D 2 3.247 0.276 V.FIFPPSDEQLK.S 1 2.142 0.183 V.TEQDSKDSTYSLSSTLTLSK.A 2 4.292 0.480 W.KVDNALQSGNSQESVTEQDSK.D 3 5.200 0.361 Y.EKHKVYACEVTHQGLSSPVTK.S 3 4.098 0.211 Y.SNLAWYQQK.Q 1 2.367 0.232 2 3.143 0.261 P27144 homo sapiens (human). adenylate kinase isoenzyme 4, K.LLRAVILGPPGSGKGTVCQRIAQNFGL IPI:IPI00180944.1 SW:KAD4_HUMAN 3 3.653 0.152 P mitochondrial (ec 2.7.4.3) (atp-amp QHLSSGHFLREN.I (99%) transphosphorylase). 10/2001 P29622 homo sapiens (human). kallistatin precursor (kallikrein IPI:IPI00022902.1 SW:KAIN_HUMAN K.DFYVDENTTVR.V 2 3.237 0.229 O, P inhibitor) (protease inhibitor 4). (95%) 10/2001 K.FFSAQTNR.H 1 2.111 0.150 K.FSISGSYVLDQILPR.L 2 2.676 0.187 K.IAPANADFAFR.F 2 2.593 0.205 K.LFHTNFYDTVGTIQLINDHVK.K 3 5.115 0.406 R.LGFTDLFSK.W 1 2.123 0.257 R.VGSALFLSHNLK.F 2 3.574 0.264 R.VPMMLQDQEHHWYLHDR.Y 3 3.689 0.321 P03952 homo sapiens (human). plasma kallikrein precursor (ec IPI:IPI00008558.1 SW:KAL_HUMAN K.EIIIHQNYK.V 2 2.726 0.162 A, G, O, P 3.4.21.34) (plasma prekallikrein) (98%) (kininogenin) (fletcher factor). 10/2001 K.EKGEIQNILQK.V 2 3.239 0.244 K.VAEYMDWILEK.T 2 3.843 0.301 K.VSEGNHDIALIK.L 2 3.038 0.175 R.IAYGTQGSSGYSLR.L 2 3.259 0.454 R.REQPGVYTK.V 2 2.885 0.332 R.TGAVSGHSLK.Q 2 2.974 0.266 W.KIESQRNVCLLK.T 2 2.745 0.090 P19838 homo sapiens (human). nuclear factor nf-kappa-b p105 subunit IPI:IPI00021015.2 SW:KBF1_HUMAN (dna-binding factor kbf1) (ebp- 1) R.ELVEALRQMGYTE.A 2 2.785 0.099 G (95%) [contains: nuclear factor nf-kappa-b p50 subunit]. 10/2001 P19784 homo sapiens (human). IPI:IPI00020602.1 SW:KC22_HUMAN casein kinase ii, alpha' chain (ck ii) (ec R.GGTNIIKLIDTVKDPVSK.T 1 1.985 0.101 O (93%) 2.7.1.37). 10/2001 Q14012 homo sapiens (human). calcium/calmodulin-dependent protein SW:KCC1_HUMAN E.FDSPYWDDISDSAKDFIR.N 2 2.539 0.112 P kinase type i (ec 2.7.1.123) (cam kinase i). 10/2001 Q16760 homo sapiens (human). diacylglycerol kinase, delta (ec SW:KDGD_HUMA 2.7.1.107) (diglyceride kinase) (dgk- IPI:IPI00218290.1 Q.LPQILEKLERA.S 2 2.902 0.119 G N delta) (dag kinase delta) (130 kda (96%) diacylglycerol kinase) (fragment). 10/2001 P49619 homo sapiens (human). diacylglycerol kinase, gamma (ec SW:KDGG_HUMA IPI:IPI00027658.1 2.7.1.107) (diglyceride kinase) (dgk- K.ILKDIEQSPLVMLDRWHL.E 2 2.525 0.167 A N (96%) gamma) (dag kinase gamma). 10/2001 SW:KEND_HUMA O95613 homo sapiens (human). G.RKDHVDELEPER.H 1 1.878 0.109 A, G N kendrin. 10/2001 K.KTAKRKGSAVDASVQEESPVTKEDSAL 3 3.803 0.135 CGGGDICKSTS.C O43896 homo sapiens (human). SW:KF1C_HUMAN P.PSPPLSSWERVSRLMEEDPAFR.R 2 2.583 0.088 P kinesin-like protein kif1c. 10/2001 Supplementary Table 1 254 Q9y496 homo sapiens (human). kinesin-like protein kif3a (microtubule K.NIKNKARINEDPKDALLRQFQKEIEELK. SW:KF3A_HUMAN 3 3.760 0.229 A plus end-directed kinesin motor 3a). K 10/2001 O95239 homo sapiens (human). IPI:IPI00178150.1 SW:KF4A_HUMAN chromosome-associated kinesin kif4a L.KENVEIICNLQQ.L 2 2.889 0.177 A, O (94%) (chromokinesin). 10/2001 P50053 homo sapiens (human). SW:KHK_HUMAN ketohexokinase (ec 2.7.1.3) (hepatic F.PPPRVVDTLGAGDTFNASV.I 1 2.085 0.116 G fructokinase). 10/2001 P46013 homo sapiens (human). IPI:IPI00004233.1 SW:KI67_HUMAN G.RNAADPISGDFKEISSVKLVSR.Y 2 2.328 0.104 G antigen ki-67. 10/2001 (97%) L.KIPLVKVDMKE.E 1 2.066 0.161 S.KAVGASFPLY.E 1 2.021 0.081 Q9haq2 homo sapiens (human). IPI:IPI00221112.1 SW:KIF9_HUMAN V.IPEDMQMALKP.G 2 2.715 0.117 O, P kinesin-like protein kif9. 10/2001 (95%) P33176 homo sapiens (human). IPI:IPI00012837.1 SW:KINH_HUMAN kinesin heavy chain (ubiquitous C.KQLESTQTESNK.K 2 2.603 0.107 G (97%) kinesin heavy chain) (ukhc). 10/2001 Q12840 homo sapiens (human). neuronal kinesin heavy chain (nkhc) SW:KINN_HUMAN (kinesin heavy chain isoform 5a) K.LEAELSRWR.N 2 2.532 0.124 O (kinesin heavy chain neuron-specific 1). 10/2001 R.QLARLRDEINEKQK.T 2 2.537 0.084 O75838 homo sapiens (human). IPI:IPI00027169.1 SW:KIP2_HUMAN kinase interacting protein 2 (kip 2). E.LDEEEVVLVCDKVIEEA.D 2 3.078 0.127 G (92%) 10/2001 P07288 homo sapiens (human). prostate specific antigen precursor (ec 3.4.21.77) (psa) (gamma- SW:KLK3_HUMAN H.DLMLLRL.S 2 2.642 0.081 P seminoprotein) (kallikrein 3) (semenogelase) (seminin) (p-30 antigen). 10/2001 P01042 homo sapiens (human). kininogen precursor (alpha-2-thiol IPI:IPI00215894.1 SW:KNG_HUMAN F.KLDDDLEHQGGHVLDHGHK.H 3 3.697 0.343 G, O, P proteinase inhibitor) [contains: (93%) bradykinin]. 10/2001 I.PTNSPELEETLTHTITK.L 2 4.286 0.491 3 3.800 0.398 K.AVDAALKK.Y 2 2.340 0.130 K.DFVQPPTK.I 1 1.926 0.127 K.FKLDDDLEHQGGHVLDHGHK.H 2 5.141 0.368 3 4.570 0.408 K.KYFIDFVAR.E 2 3.431 0.350 K.KYNSQNQSNNQFVLYR.I 2 4.858 0.512 3 4.811 0.365 K.LDDDLEHQGGHVLDHGHK.H 2 3.774 0.335 3 3.665 0.229 K.RPPGFSPFR.S 2 3.084 0.288 K.TVGSDTFYSFK.Y 1 2.243 0.262 2 3.230 0.208 K.YFIDFVAR.E 1 1.962 0.170 K.YNSQNQSNNQFVLYR.I 2 4.145 0.394 3 4.780 0.384 N.SPELEETLTHTITK.L 2 4.572 0.435 N.SQNQSNNQFVLYR.I 2 3.365 0.420 R.DIPTNSPELEETLTHTITK.L 2 3.932 0.447 R.GHGLGHGHEQQHGLGHGHK.F 2 4.151 0.461 3 3.692 0.281 R.HDWGHEK.Q 2 2.544 0.081 R.RHDWGHEK.Q 2 2.287 0.234 R.VQVVAGK.K 1 2.407 0.092 R.VQVVAGKK.Y 1 1.992 0.098 Y.FIDFVAR.E 1 1.814 0.127 2 2.633 0.179 Y.NSQNQSNNQFVLYR.I 2 4.428 0.234 P17252 homo sapiens (human). SW:KPCA_HUMA IPI:IPI00178455.1 protein kinase c, alpha type (ec 2.7.1.- F.LHKRGIIYRDLKLDNVMLDS.E 2 3.193 0.100 O, P N (96%) ) (pkc-alpha). 7/1999 Supplementary Table 1 255 Q02156 homo sapiens (human). SW:KPCE_HUMA IPI:IPI00024539.1 protein kinase c, epsilon type (ec K.IKPPFKPRIK.T 1 1.830 0.104 O N (97%) 2.7.1.-) (npkc-epsilon). 7/1999 Q15139 homo sapiens (human). SW:KPCM_HUMA IPI:IPI00014878.1 protein kinase c, mu type (ec 2.7.1.-) P.EHITKFLITQILVALRHLHFKNIV.H 3 3.805 0.136 A N (97%) (npkc-mu). 10/2001 P14786 homo sapiens (human). IPI:IPI00183506.1 SW:KPY2_HUMAN pyruvate kinase, m2 isozyme (ec L.DGADCIMLSG.E 1 2.054 0.128 G (99%) 2.7.1.40). 10/2001 P15056 homo sapiens (human). b-raf proto-oncogene serine/threonine- SW:KRAB_HUMA IPI:IPI00177003.1 protein kinase (ec 2.7.1.-) (p94) (v-raf G.GGGGGAEPGQALFNGDMEPEAGA.G 2 2.417 0.302 A N (91%) murine sarcoma viral oncogene homolog b1). 10/2001 S.AADPAIPEEVWNIKQMI.K 2 2.462 0.120 P01593 homo sapiens (human). ig SW:KV1A_HUMAN G.ASNLETGVPSR.F 2 3.295 0.281 G kappa chain v-i region ag. 7/1999 K.ILIYDASNLETGVPSR.F 2 4.337 0.303 P01594 homo sapiens (human). ig SW:KV1B_HUMAN A.ASNLESGVPSR.F 1 2.222 0.160 G, O, P kappa chain v-i region au. 7/1999 2 3.765 0.284 Y.AASNLESGVPSR.F 2 2.911 0.228 P01595 homo sapiens (human). ig SW:KV1C_HUMAN -.DIQMTQSPSPL.S 2 2.634 0.332 G kappa chain v-i region bi. 7/1999 P01597 homo sapiens (human). ig SW:KV1E_HUMAN -.BIZMTQSPSS.L 2 3.520 0.297 G, O, P kappa chain v-i region dee. 7/1999 -.BIZMTQSPSSL.S 2 3.564 0.330 -.BIZMTQSPSSLSA.S 2 3.973 0.194 -.BIZMTQSPSSLSAS.V 2 3.710 0.325 -.BIZMTQSPSSLSASVGDR.V 1 3.856 0.340 2 6.253 1.000 3 4.123 1.000 A.ASSLKSGVPSR.F 1 2.202 0.182 2 3.477 0.318 A.SSLKSGVPSR.F 1 1.874 0.096 F.AASSLKSGVPSR.F 2 3.269 0.298 S.SLKSGVPSR.F 1 1.949 0.108 P01599 homo sapiens (human). ig SW:KV1G_HUMAN G.ASNLQSGVPSR.F 1 1.871 0.155 G kappa chain v-i region gal. 7/1999 2 3.096 1.000 S.NLQSGVPSR.F 1 1.913 0.091 Y.AASNLQSGVPSR.F 2 3.796 0.263 P01601 homo sapiens (human). ig L.LLCFPGARCDIQMTQSPSSLSASVGDR IPI:IPI00160257.2 SW:KV1I_HUMAN kappa chain v-i region hk101 3 3.944 0.094 G, O, P .V (93%) precursor (fragment). 7/1999 P01602 homo sapiens (human). ig IPI:IPI00003115.1 SW:KV1J_HUMAN kappa chain v-i region hk102 A.WYQQKPGKVPK.L 2 2.698 0.090 G, O, P (93%) precursor (fragment). 7/1999 C.DIQMTQSPSTL.S 2 3.647 0.292 C.DIQMTQSPSTLSA.S 2 4.168 0.304 C.DIQMTQSPSTLSAS.V 2 4.088 0.404 C.DIQMTQSPSTLSASVGDR.V 1 2.865 0.266 2 5.807 0.406 K.ASSLESGVPSR.F 1 2.074 0.199 2 3.752 0.334 Q.MTQSPSTLSASVGDR.V 2 2.720 0.253 P01606 homo sapiens (human). ig SW:KV1N_HUMAN -.DIQMTZSPSS.L 2 3.252 0.226 G, P kappa chain v-i region ou. 7/1999 -.DIQMTZSPSSL.S 2 3.561 0.362 -.DIQMTZSPSSLSA.S 2 3.977 0.326 -.DIQMTZSPSSLSASVGBR.V 1 2.808 0.138 P01607 homo sapiens (human). ig SW:KV1O_HUMAN S.YLNWYQQTPGK.A 2 2.793 0.357 G kappa chain v-i region rei. 7/1999 P01608 homo sapiens (human). ig SW:KV1P_HUMAN K.LLIYDASK.L 1 1.998 0.118 G kappa chain v-i region roy. 7/1999 P01609 homo sapiens (human). ig SW:KV1Q_HUMAN F.SGSGSGTEFTLSIS.S 1 2.200 0.161 G kappa chain v-i region scw. 7/1999 K.ASTLETGVPSR.F 2 3.127 0.312 P01610 homo sapiens (human). ig SW:KV1R_HUMAN Y.GATSLQSGVPSR.F 2 3.778 0.237 G kappa chain v-i region wea. 7/1999
Supplementary Table 1 256 P01611 homo sapiens (human). ig SW:KV1S_HUMAN C.DIQMTQSPSSVSA.S 2 4.115 0.344 A, G, O, P kappa chain v-i region wes. 7/1999 C.DIQMTQSPSSVSAS.V 2 3.254 0.220 C.DIQMTQSPSSVSASVGDR.L 1 2.139 0.155 2 5.927 0.474 Q.SPSSVSASVGDR.L 2 3.296 0.303 R.CDIQMTQSPSSVSASVGDR.L 2 2.270 0.106 S.SVSASVGDR.L 1 1.808 0.119 T.QSPSSVSASVGDR.L 2 3.105 0.390 T.YLAWFQQK.P 1 2.293 0.187 2 2.628 0.295 P01612 homo sapiens (human). ig SW:KV1T_HUMAN -.DVQMTQSPSSL.S 2 2.841 0.347 G, O, P kappa chain v-i region mev. 7/1999 -.DVQMTQSPSSLSA.S 2 3.019 0.344 -.DVQMTQSPSSLSASVGDR.I 2 5.404 0.504 P01613 homo sapiens (human). ig SW:KV1U_HUMAN -.DIQMTQSPSSLSATV.G 2 3.978 0.383 G kappa chain v-i region ni. 7/1999 -.DIQMTQSPSSLSATVGDR.V 2 2.433 0.183 E.LLIYDASNLETGVPSR.L 1 2.325 0.167 2 4.558 0.299 L.IYDASNLETGVPSR.L 2 3.981 0.423 P04430 homo sapiens (human). ig SW:KV1V_HUMAN -.DIQLTQSPSSL.S 2 4.129 0.170 G, O, P kappa chain v-i region ban. 7/1999 -.DIQLTQSPSSLSA.F 1 3.015 0.219 2 4.319 0.306 -.DIQLTQSPSSLSASVGDR.V 1 1.991 0.255 2 6.036 0.529 P.FLNWYQQKPGK.A 2 2.720 0.161 P04431 homo sapiens (human). ig SW:KV1W_HUMA IPI:IPI00024134.1 kappa chain v-i region walker R.ASQSISNYLNWYQQKPGK.A 2 4.130 0.154 G N (93%) precursor. 7/1999 P04432 homo sapiens (human). ig IPI:IPI00024135.1 SW:KV1X_HUMAN kappa chain v-i region daudi -.DIQMTQSPSSL.S 1 2.145 0.159 G, O, P (93%) precursor. 7/1999 2 3.367 0.292 -.DIQMTQSPSSLSA.S 2 4.080 0.359 -.DIQMTQSPSSLSASVGDR.V 1 4.010 1.000 2 6.159 1.000 M.TQSPSSLSASVGDR.V 2 2.827 0.244 N.WYQQKPGK.A 1 2.153 0.083 N.YLNWYQQK.P 1 2.210 0.151 2 2.545 0.148 N.YLNWYQQKPGK.A 2 3.348 1.000 Q.SPSSLSASVGDR.V 1 2.101 0.253 Y.LNWYQQKPGK.A 2 2.958 0.125 P01616 homo sapiens (human). ig SW:KV2C_HUMAN R.FSGSGSGTBFTLKISR.V 2 2.820 0.101 G kappa chain v-ii region mil. 7/1999 P01617 homo sapiens (human). ig SW:KV2D_HUMAN -.DIVMTQSPL.S 1 2.284 0.245 G kappa chain v-ii region tew. 7/1999 P06309 homo sapiens (human). ig IPI:IPI00184715.1 SW:KV2E_HUMAN kappa chain v-ii region gm607 P.YTFGQGTK.L 1 1.903 0.129 G, O, P (96%) precursor (fragment). 7/1999 Q.TPYTFGQGTK.L 1 2.635 0.330 R.ASGVPDRFSGSGSGTDFTLK.I 2 3.850 0.401 R.PGQSPQLLIYLGSNR.A 2 2.876 0.303 P06310 homo sapiens (human). ig IPI:IPI00152918.1 SW:KV2F_HUMAN kappa chain v-ii region rpmi 6410 R.SSQSLVYSDGNTYLNWFQQR.P 2 5.395 0.494 G, O (96%) precursor. 7/1999 P01619 homo sapiens (human). ig SW:KV3A_HUMAN -.ZIVLTZSPGTLSL.S 2 4.400 0.195 G, O, P kappa chain v-iii region b6. 7/1999 -.ZIVLTZSPGTLSLSPGZR.A 1 2.953 0.212 2 3.767 0.193 P01620 homo sapiens (human). ig IPI:IPI00030206.1 SW:KV3B_HUMAN R.ASQSVSNSYLAWYQQKPGQAPR.L 2 3.434 0.084 G kappa chain v-iii region sie. 7/1999 (96%) P01622 homo sapiens (human). ig IPI:IPI00030206.1 SW:KV3D_HUMAN S.FLAWYQQKPGQAPR.L 2 3.392 0.393 G, P kappa chain v-iii region ti. 7/1999 (94%) P01624 homo sapiens (human). ig IPI:IPI00022862.1 SW:KV3F_HUMAN -.EIVMTQSPVTLSVSPGER.A 1 2.506 0.228 G, O, P kappa chain v-iii region pom. 10/2001 (91%) 2 5.214 0.447 Supplementary Table 1 257 P04206 homo sapiens (human). ig IPI:IPI00030205.1 SW:KV3G_HUMAN kappa chain v-iii region gol -.EIVLTQSPGTLSLSPGER.A 1 3.308 0.293 A, G, O, P (91%) (rheumatoid factor). 7/1999 2 5.672 0.358 3 4.756 0.325 E.IVLTQSPGTLSLSPGER.A 2 4.237 0.435 I.VLTQSPGTLSLSPGER.A 2 3.750 0.424 S.GYLAWYQQK.P 2 2.931 0.215 P04207 homo sapiens (human). ig IPI:IPI00022862.1 SW:KV3H_HUMAN kappa chain v-iii region cll precursor -.EIVMTQSPATL.S 2 3.323 0.360 G (93%) (rheumatoid factor). 7/1999 -.EIVMTQSPATLSVSPGER.A 1 3.368 0.332 2 5.438 0.406 3 3.564 0.301 E.IVMTQSPATLSVSPGER.A 2 4.032 0.443 I.VMTQSPATLSVSPGER.A 2 3.678 0.329 M.TQSPATLSVSPGER.A 2 3.969 0.339 Q.SVSNNLAWYQQKPGQPPR.L 2 3.101 0.315 R.ASQSVSNNLAWYQQK.P 2 3.320 0.349 R.FSGSGSGTEFTLTISR.L 2 3.515 1.000 R.SNLAWYQQKPGQAPR.L 2 3.960 0.304 S.LAWYQQKPGQPPR.L 2 3.117 0.147 S.NNLAWYQQK.P 2 2.610 0.188 S.NNLAWYQQKPGQ.A 2 3.138 0.260 S.SLAWYQQK.P 1 1.818 0.168 S.SSLAWYQQK.P 2 2.427 0.203 T.QSPATLSVSPGER.A 2 2.935 0.263 V.SSSLAWYQQK.P 1 2.674 0.102 2 2.744 0.088 P04433 homo sapiens (human). ig IPI:IPI00003489.1 SW:KV3I_HUMAN kappa chain v-iii region vg precursor -.EIVLTQSPATL.S 1 2.580 0.266 A, G, O, P (92%) (fragment). 7/1999 2 3.820 0.211 -.EIVLTQSPATLSLSPGER.A 1 2.975 0.291 2 5.160 0.390 3 3.962 0.321 -.EIVMTQSPATLSLSPGER.A 2 4.126 0.365 E.IVLTQSPATLSLSPGER.A 2 3.230 0.396 Q.SVSSYLAWYQQK.P 2 2.808 0.130 Q.SVSSYLAWYQQKPGQAPR.L 2 2.377 0.117 R.ASQSVSSYLAWYQQK.P 1 3.646 0.198 2 2.523 0.172 R.ASQSVSSYLAWYQQKPGQAPR.L 2 4.364 0.233 3 3.940 0.205 R.LLIYDASNR.A 1 1.878 0.093 2 2.763 0.125 P06311 homo sapiens (human). ig IPI:IPI00026196.1 SW:KV3K_HUMAN kappa chain v-iii region iarc/bl41 G.EIVLTQSPGTLSLSPGESA.T 2 3.483 0.139 G (92%) precursor. 7/1999 S.SPYTFGQGTK.L 1 2.064 0.303 P18136 homo sapiens (human). ig SW:KV3M_HUMA IPI:IPI00003485.1 kappa chain v-iii region hic precursor. K.GTVAAPSVFIFPPSDEQLK.S 2 3.820 0.426 A, G, O, P N (96%) 7/1999 L.LIYGASTR.A 2 2.503 0.234 Q.SPGTLSLSPGER.A 1 1.986 0.164 R.FSGSGSGTDFTLTISR.L 1 2.338 0.214 2 4.858 0.481 R.LLIYGASTR.A 2 2.675 0.206 S.PGTLSLSPGER.A 1 2.372 0.305 S.SSYLAWYQQK.P 2 2.214 0.136 S.SYLAWYQQK.P 1 2.603 0.317 S.YLAWYQQK.P 1 2.574 0.123 2 2.769 0.296 S.YLAWYQQKPGQAPR.L 2 4.224 1.000 T.QSPGTLSLSPGER.A 2 2.652 0.273 V.SPWTFGQGTK.V 1 2.358 0.122 Supplementary Table 1 258 W.YQQKPGQAPR.L 2 2.455 0.215 Y.LAWYQQKPGQAPR.L 2 3.569 1.000 P06313 homo sapiens (human). ig IPI:IPI00026197.1 SW:KV4B_HUMAN kappa chain v-iv region ji precursor. M.TQSPDSLAVSLGER.A 2 2.254 0.105 G, P (97%) 7/1999 T.LLIYWASTR.Q 1 1.945 0.174 2 3.209 0.215 P06314 homo sapiens (human). ig IPI:IPI00026197.1 SW:KV4C_HUMAN kappa chain v-iv region b17 precursor. G.DIVMTQSPDSLAV.S 2 2.663 0.233 G (96%) 7/1999 G.DIVMTQSPDSLAVSLGER.A 1 3.396 0.314 2 6.025 0.419 3 3.715 0.313 K.NYLAWYQQKPGQPPK.L 1 3.244 0.323 2 4.315 0.417 K.SSQSILYSSDNK.N 2 3.699 0.364 K.SSQSVLYSSNNK.N 1 2.729 0.392 2 3.978 0.301 P01842 homo sapiens (human). ig IPI:IPI00178482.1 SW:LAC_HUMAN -.SYELTQPPSVSVSPGQTAR.I 2 4.734 0.497 A, G, O, P lambda chain c regions. 10/2001 (99%) 3 4.462 0.454 A.ASSYLSLTPEQW.K 2 2.943 0.145 A.ASSYLSLTPEQWK.S 1 3.343 0.308 2 4.200 0.300 A.PSVTLFPPSSEELQANK.A 2 3.226 0.290 A.SSYLSLTPEQWK.S 1 2.751 0.330 2 3.859 0.336 C.LISDFYPGAVTVAWK.A 2 2.488 0.328 C.QVTHEGSTVEK.T 2 2.292 0.126 D.FYPGAVTVAWK.A 1 2.353 0.107 D.SSPVKAGVETTTPSK.Q 2 3.975 0.432 F.PPSSEELQA.N 1 2.072 0.172 F.PPSSEELQANK.A 1 3.422 0.155 2 3.825 0.224 K.AAPSVTLFPPSSEEL.Q 1 2.290 0.258 2 2.413 0.113 K.AAPSVTLFPPSSEELQA.N 1 2.822 0.360 K.AAPSVTLFPPSSEELQAN.K 1 3.138 0.362 K.AAPSVTLFPPSSEELQANK.A 1 3.449 0.239 2 3.761 0.336 3 3.673 0.247 K.ADSSPVKAGVETTTPSK.Q 1 3.679 0.369 2 3.730 0.417 3 3.734 0.305 K.ADSSPVKAGVETTTPSKQSNNK.Y 2 2.929 0.158 3 4.608 0.261 K.AGVETTTPSK.Q 1 2.186 0.268 2 3.556 0.307 K.AGVETTTPSKQS.N 2 2.863 0.310 K.AGVETTTPSKQSNNK.Y 1 3.370 0.215 2 4.425 0.377 K.AGVETTTPSKQSNNKYAASSYLSLTPE 3 5.862 0.385 QWK.S K.LTVLGQPK.A 1 2.011 0.194 2 2.261 0.138 K.QSNNKYAASSYLSLTPEQ.W 2 3.530 0.267 K.QSNNKYAASSYLSLTPEQWK.S 2 5.979 0.442 3 3.949 0.260 K.YAASSYLSLTPEQWK.S 1 3.644 0.475 2 5.756 0.405 3 3.818 0.138 L.FPPSSEELQANK.A 1 2.884 0.145 L.ISDFYPGAVTVAWK.A 1 3.042 0.365 2 3.693 0.353 L.QANKATLVCLISDFYPGAVTVAWK.A 2 2.735 0.290 Supplementary Table 1 259 L.TVLGQPK.A 1 1.963 0.189 N.KYAASSYLSLTPEQWK.S 2 2.709 0.153 N.QYAYWYQQK.P 1 2.761 0.147 2 3.311 0.290 P.PSSEELQANK.A 1 2.696 0.135 Q.PPSVSVSPGQTAR.I 1 2.089 0.128 Q.VTHEGSTVEK.T 1 3.245 0.320 2 2.467 0.214 Q.YAYWYQQK.P 1 2.488 0.216 R.SYSCQVTHEGSTVEK.T 1 3.091 0.291 2 4.882 0.487 S.SYLSLTPEQWK.S 1 2.100 0.110 2 3.396 0.182 S.YELTQPPSVSVSPGQTAR.I 2 4.665 0.440 S.YLSLTPEQWK.S 1 2.407 0.213 2 3.072 0.137 T.HEGSTVEK.T 1 1.899 0.151 V.TLFPPSSEELQANK.A 1 2.061 0.200 Y.AASSYLSLTPEQWK.S 1 2.986 0.317 2 3.800 0.267 Y.LSLTPEQWK.S 1 2.301 0.138 Y.SCQVTHEGSTVEK.T 2 2.315 0.200 P18428 homo sapiens (human). IPI:IPI00032311.1 SW:LBP_HUMAN lipopolysaccharide-binding protein K.GLQYAAQEGLLALQSELLR.I 2 5.878 0.314 O, P (96%) precursor (lbp). 10/2001 3 6.017 0.335 K.LAEGFPLPLLK.R 2 3.319 0.275 R.ITLPDFTGDLR.I 2 2.373 0.291 P04180 homo sapiens (human). phosphatidylcholine-sterol acyltransferase precursor (ec IPI:IPI00022331.1 SW:LCAT_HUMAN R.ITTTSPWMFPSR.M 2 2.624 0.322 G, O 2.3.1.43) (lecithin-cholesterol (96%) acyltransferase) (phospholipid- cholesterol acyltransferase). 10/2001 R.SSGLVSNAPGVQIR.V 2 3.445 0.265 R.TYIYDHGFPYTDPVGVLYEDGDDTVAT 3 4.058 0.388 R.S O15270 homo sapiens (human). serine palmitoyltransferase 2 (ec 2.3.1.50) (long chain base IPI:IPI00005751.1 SW:LCB2_HUMAN I.FKHNNMQSLEK.L 2 2.704 0.095 A biosynthesis protein 2) (lcb 2) (serine- (96%) palmitoyl-coa transferase 2) (spt 2). 5/2000 I.TSMKCIMGQDGTSLGKECVQQLAENTR 3 3.803 0.313 YFR.R P41215 homo sapiens (human). long- chain-fatty-acid--coa ligase 1 (ec IPI:IPI00013161.1 SW:LCFA_HUMAN 6.2.1.3) (long-chain acyl-coa M.DDLKVLQPTVFPVVPRLL.N 2 3.311 0.128 G (98%) synthetase 1) (lacs 1) (palmitoyl-coa ligase). 10/2001 P07195 homo sapiens (human). l- SW:LDHH_HUMA G.KSLADELALVDVLEDKLKGEMMDLQH lactate dehydrogenase h chain (ec 3 3.634 0.135 G N GSLFLQTPK.I 1.1.1.27) (ldh-b). 10/2001 O00182 homo sapiens (human). IPI:IPI00010477.1 SW:LEG9_HUMAN galectin-9 (hom-hd-21) (ecalectin). A.NPAPITQ.T 1 2.126 0.084 P (91%) 10/2001 Q99538 homo sapiens (human). SW:LEGU_HUMA legumain precursor (ec 3.4.22.34) I.VVMMYDDIAYSEDNPTPGIV.I 2 2.958 0.099 G N (asparaginyl endopeptidase). 10/2001 P48357 homo sapiens (human). leptin IPI:IPI00219709.1 SW:LEPR_HUMAN receptor precursor (lep-r) (ob receptor) E.IEAQAFFILSDQHPNII.S 1 2.559 0.112 A (98%) (ob-r). 10/2001 P50458 homo sapiens (human). SW:LHX2_HUMAN lim/homeobox protein lhx2 (homeobox L.CAGCGGK.I 1 1.879 0.111 O, P protein lh-2). 10/2001 R.YYLLAVDKQWHMRCLK.C 2 2.408 0.160 O75627 homo sapiens (human). probable lipoate-protein ligase b (ec SW:LIPB_HUMAN T.QLPIVQSDRGGQV.T 2 2.822 0.135 O 6.-.-.-) (lipoate biosynthesis protein b) (fragment). 10/2001 SW:LIPH_HUMAN P11150 homo sapiens (human). G.CHFLELYR.H 1 1.848 0.085 G, O Supplementary Table 1 260 triacylglycerol lipase, hepatic precursor (ec 3.1.1.3) (hepatic lipase) (hl). 10/2001 2 2.989 0.133 Q.FINQTETPIQTTF.T 1 2.052 0.160 P05451 homo sapiens lithostathine 1 alpha precursor (pancreatic stone protein) (psp) (pancreatic thread SW:LITA_HUMAN K.DVPCEDKF.S 1 2.460 0.085 A protein) (ptp) (islet of langerhans regenerating protein) (reg) (regenerating protei Q16787 homo sapiens (human). laminin alpha-3 chain precursor IPI:IPI00016039.1 SW:LMA3_HUMAN R.LNYTKGATSSKPETPGVYDM.D 2 2.952 0.091 G, O (epiligrin 170 kda subunit) (e170). (97%) 10/2001 T.QSAKELDVKIKNVI.R 2 2.487 0.136 P29536 homo sapiens (human). leiomodin 1 (leiomodin, muscle form) (64 kda autoantigen d1) (64 kda SW:LMD1_HUMAN K.NSRDQLLAAIRS.S 1 2.475 0.147 P autoantigen 1d) (64 kda autoantigen 1d3) (thyroid-associated ophthalmopathy autoantigen) ( P13473 homo sapiens (human). lysosome-associated membrane SW:LMP2_HUMAN I.SMYLVNGSVFSIANNNLSYWDAP.L 2 2.991 0.088 G glycoprotein 2 precursor (lamp-2) (cd107b antigen). 10/2001 P09848 homo sapiens (human). lactase-phlorizin hydrolase precursor (lactase-glycosylceramidase) IPI:IPI00017648.1 SW:LPH_HUMAN H.VVFIALLSFSCWGSDWESDRNF.I 2 2.465 0.250 G, O [includes: lactase (ec 3.2.1.108); (98%) phlorizin hydrolase (ec 3.2.1.62)]. 10/2001 L.EEVIKELPHQE.S 2 2.626 0.147 Q07954 homo sapiens (human). low- density lipoprotein receptor-related protein 1 precursor (lrp) (alpha-2- IPI:IPI00020557.1 SW:LRP1_HUMAN C.QPGEFACANSR.C 1 1.801 0.094 A, G, O, P macroglobulin receptor) (a2mr) (96%) (apolipoprotein e receptor) (apoer) (cd91). 10/2001 I.EVARLNGSFRYVVISQGLDKPRAITVHP 3 3.795 0.087 EK.G Q.NRTKLVDSKIVFPHGITLDLVSR.L 2 2.362 0.202 R.QKGTNVCAVANGGCQQ.L 1 1.838 0.143 T.NWNEQHPSIMRAALSGANVLTLI.E 2 2.419 0.129 Y.WVDAFYDRIETILLNGTDRKIVYEGPEL. 2 2.607 0.133 N P33241 homo sapiens (human). lymphocyte-specific protein lsp1 (pp52 IPI:IPI00163660.1 SW:LSP1_HUMAN protein) (52 kda phosphoprotein) D.EVHLEELSLSK.E 1 2.346 0.138 P (93%) (lymphocyte-specific antigen wp34). 10/2001 P51884 homo sapiens (human). IPI:IPI00020986.2 SW:LUM_HUMAN lumican precursor (lum) (keratan K.ISNIPDEYFK.R 2 2.716 0.121 G, O, P (94%) sulfate proteoglycan). 10/2001 K.NIPTVNENLENYYLEVNQLEK.F 2 5.211 0.474 K.RFNALQYLR.L 2 3.327 0.298 K.SLEDLQLTHNK.I 1 2.594 0.146 2 3.873 0.280 K.SLEYLDLSFNQIAR.L 2 4.060 0.323 R.FNALQYLR.L 2 3.030 0.256 R.LKEDAVSAAFK.G 1 2.732 0.365 2 3.413 0.286 R.LPSGLPVSLLTLYLDNNK.I 2 4.711 0.380 R.NNQIDHIDEK.A 2 3.602 0.315 Y.YLEVNQLEKFDIKSFCK.I 2 2.502 0.082 P04211 homo sapiens (human). ig SW:LV0A_HUMAN lambda chain v region 4a precursor. K.HSWTPAR.F 1 1.816 0.217 G, O 7/1999 R.FSGSLLGGK.A 1 2.085 0.117 2 2.344 0.110 P01699 homo sapiens (human). ig SW:LV1A_HUMAN Q.SVLTQPPSASGTPGQR.V 2 3.839 0.345 G, O lambda chain v-i region vor. 7/1999 S.VLTQPPSASGTPGQR.V 2 3.447 0.366 Supplementary Table 1 261 P01700 homo sapiens (human). ig SW:LV1B_HUMAN G.NNQRPSGVPDR.F 2 2.593 0.125 G lambda chain v-i region ha. 7/1999 K.LLIYGNNQR.P 2 2.938 0.161 K.LTVLSQPK.A 2 2.608 0.194 K.SGTSASLAISGLR.S 1 2.212 0.352 2 3.609 0.375 S.NYVYWYQQLPGTAPK.L 2 2.673 0.230 T.APKLLIYR.N 1 2.503 0.081 V.LFGGGTK.L 1 1.810 0.129 P01701 homo sapiens (human). ig SW:LV1C_HUMAN L.TQPPSVSAAPGQK.V 2 2.360 0.185 G, O lambda chain v-i region new. 7/1999 N.IGNNYVSWYQQFPGTAPK.L 2 3.581 0.423 N.NYVSWYQQFPGTAPK.L 2 3.268 0.272 Q.PPSVSAAPGQK.V 1 3.096 0.312 Q.SVLTQPPSVSAAPGQK.V 2 3.853 0.345 S.VLTQPPSVSAAPGQK.V 2 3.341 0.346 P04208 homo sapiens (human). ig IPI:IPI00045547.1 SW:LV1F_HUMAN E.DNQRPSGVPDR.F 2 2.884 0.213 O, P lambda chain v-i region wah. 7/1999 (92%) P06316 homo sapiens (human). ig SW:LV1G_HUMAN lambda chain v-i region bl2 precursor. N.WYQQVPGTAPK.L 2 3.097 0.244 G 7/1999 P06887 homo sapiens (human). ig SW:LV1H_HUMAN H.YVFGTGTK.V 1 2.320 0.238 G lambda chain v-i region mem. 7/1999 P01704 homo sapiens (human). ig SW:LV2A_HUMAN D.YVSWYQQYPGK.A 2 3.666 0.293 G lambda chain v-ii region tog. 7/1999 P01705 homo sapiens (human). ig SW:LV2B_HUMAN H.RPSGVSNR.F 1 1.941 0.083 G, O, P lambda chain v-ii region nei. 7/1999 2 2.960 0.103 P01707 homo sapiens (human). ig SW:LV2D_HUMAN K.LMIFDVTKRPSGVPDR.L 2 2.638 0.127 G lambda chain v-ii region tro. 7/1999 P01708 homo sapiens (human). ig SW:LV2E_HUMAN N.YVSWYQQHPGK.A 1 2.435 0.095 G, O, P lambda chain v-ii region bur. 7/1999 2 3.043 0.363 S.WYQQHPGK.A 2 2.481 0.179 Y.VSWYQQHPGK.A 2 2.337 0.277 P01712 homo sapiens (human). ig SW:LV2I_HUMAN G.YNHVSWYQQDPGK.V 1 2.092 0.160 G lambda chain v-ii region win. 7/1999 P04209 homo sapiens (human). ig SW:LV2K_HUMAN lambda chain v-ii region nig-84. N.FVSWYQQHPGK.A 1 2.051 0.281 G 7/1999 2 2.992 0.272 P01714 homo sapiens (human). ig SW:LV3A_HUMAN G.KHVLFGGGTK.L 1 2.453 0.261 G lambda chain v-iii region sh. 7/1999 P80748 homo sapiens (human). ig SW:LV3B_HUMAN -.YVLTQPPSVSVAPGE.T 2 4.529 0.390 A, G, O, P lambda chain v-iii region loi. 10/2001 -.YVLTQPPSVSVAPGETAR.L 1 2.802 0.264 2 5.719 0.134 3 4.146 0.236 N.SGNTATLTISR.V 2 2.956 0.219 R.FSGSNSGNTATLTISR.V 1 2.214 0.348 2 5.260 0.382 R.SAHWYQQK.P 1 1.970 0.376 S.DRPSGIPER.F 1 2.001 0.228 Y.VLTQPPSVSVAPGETAR.L 2 3.706 0.517 P01715 homo sapiens (human). ig SW:LV4A_HUMAN K.RPSGIPER.F 1 2.241 0.223 G, O, P lambda chain v-iv region bau. 7/1999 2 2.828 0.209 P01716 homo sapiens (human). ig SW:LV4B_HUMAN R.PGQSPVLVIYQDNQ.R 2 2.937 0.373 G lambda chain v-iv region x. 7/1999 P06889 homo sapiens (human). ig SW:LV4E_HUMAN K.RPSGIPZR.F 1 2.365 0.190 G lambda chain v-iv region mol. 7/1999 P01719 homo sapiens (human). ig SW:LV5A_HUMAN N.SVHWYQQK.S 1 2.807 0.208 G, O, P lambda chain v-v region del. 7/1999 2 2.829 0.221 S.YVLSQPPSVSVAPGQ.T 2 3.917 0.327 S.YVLSQPPSVSVAPGQTAR.I 2 4.191 0.416 P06317 homo sapiens (human). ig SW:LV6C_HUMAN E.DTQRPSGVPDR.F 2 2.574 0.094 O lambda chain v-vi region sut. 7/1999 P06319 homo sapiens (human). ig SW:LV6E_HUMAN -.NFMLTQPHSVSESPGK.T 1 3.327 0.323 G lambda chain v-vi region eb4 Supplementary Table 1 262 precursor. 7/1999 2 4.928 0.474 G.GVFGGGTK.S 1 1.988 0.129 O15296 homo sapiens (human). IPI:IPI00220010.1 SW:LX1B_HUMAN arachidonate 15-lipoxygenase, type ii D.HGILSGIQTNVINGKPQF.S 1 2.342 0.123 G, P (94%) (ec 1.13.11.33) (15-lox). 10/2001 T.REALVQYVTMVIFTCSAKHA.A 2 2.438 0.209 P00695 homo sapiens (human), pan troglodytes (chimpanzee), and pan paniscus (pygmy chimpanzee) SW:LYC_HUMAN K.RVVRDPQGIR.A 2 2.420 0.233 G, P (bonobo). lysozyme c precursor (ec 3.2.1.17) (1,4-beta-n- acetylmuramidase c). 10/2001 R.STDYGIFQINSR.Y 2 3.109 0.334 P07948 homo sapiens (human). IPI:IPI00215778.1 SW:LYN_HUMAN tyrosine-protein kinase lyn (ec K.GKDSLSDDGVDLKTQPVRN.T 2 3.233 0.124 A (95%) 2.7.1.112). 5/2000 P28300 homo sapiens (human). SW:LYOX_HUMAN protein-lysine 6-oxidase precursor (ec A.RHWFQAGYSTSRA.R 2 2.532 0.161 G, O 1.4.3.13) (lysyl oxidase). 10/2001 G.AAVPGAANASAQQPR.T 1 1.967 0.118 Q99698 homo sapiens (human). IPI:IPI00220899.1 SW:LYST_HUMAN lysosomal trafficking regulator (beige I.FRVCMDSNDDMKAVLLAQVESQENIF.L 2 2.578 0.128 A, P (96%) homolog). 10/2001 I.QDVKLLEELLLD.W 2 3.069 0.081 Y.TIYEPVIRLKGQMKTQL.S 2 2.615 0.132 Q13233 homo sapiens (human). mitogen-activated protein kinase SW:M3K1_HUMAN kinase kinase 1 (ec 2.7.1.-) (mapk/erk L.RKVRSVE.L 1 2.004 0.082 A, G, P kinase kinase 1) (mek kinase 1) (mekk 1) (fragment). 10/2001 P.EAGGGGGALK.A 1 1.942 0.107 S.FLIGGDSPDNK.Y 2 2.589 0.100 Q9y2u5 homo sapiens (human). mitogen-activated protein kinase SW:M3K2_HUMAN kinase kinase 2 (ec 2.7.1.-) (mapk/erk D.QQALNSIMQDLAVLHKASR.P 2 2.686 0.133 A kinase kinase 2) (mek kinase 2) (mekk 2). 10/2001 Q9y6r4 homo sapiens (human). mitogen-activated protein kinase IPI:IPI00186536.1 SW:M3K4_HUMAN kinase kinase 4 (ec 2.7.1.-) (mapk/erk V.DKALKQMGLR.K 2 2.718 0.101 O, P (96%) kinase kinase 4) (mek kinase 4) (mekk 4) (map three kinase 1). 10/2001 Q99683 homo sapiens (human). mitogen-activated protein kinase kinase kinase 5 (ec 2.7.1.-) (mapk/erk IPI:IPI00185954.1 SW:M3K5_HUMAN S.IVKLVETLEKL.P 2 3.076 0.099 A, G, O kinase kinase 5) (mek kinase 5) (mekk (92%) 5) (apoptosis signal- regulating kinase 1) (ask-1 V.LDRFYNADIAVVEMSDAFRQPSL.F 2 2.409 0.115 O43318 homo sapiens (human). mitogen-activated protein kinase kinase kinase 7 (ec 2.7.1.-) SW:M3K7_HUMAN L.ESKLLKNQAKQ.Q 2 3.079 0.112 P (transforming growth factor-beta- activated kinase 1) (tgf-beta- activated kinase 1). 10/2001 P33908 homo sapiens (human). mannosyl-oligosaccharide alpha-1,2- IPI:IPI00018145.2 SW:MA12_HUMAN K.GYAWGLNELKPISK.G 2 2.864 0.145 O mannosidase (ec 3.2.1.113) (man(9)- (95%) alpha-mannosidase). 5/2000 R.GLPPVDFVPPIGVESR.E 2 2.265 0.328 O00754 homo sapiens (human). lysosomal alpha-mannosidase SW:MA2B_HUMA IPI:IPI00012989.1 precursor (ec 3.2.1.24) (mannosidase, G.SSLRDGSLELMVHRRLLK.D 2 3.071 0.098 O, P N (95%) alpha b) (lysosomal acid alpha- mannosidase) (laman). 10/2001 O95405 homo sapiens (human). mothers against decapentaplegic homolog interacting protein (madh- IPI:IPI00026338.3 SW:MADI_HUMAN N.VKIFHGSEYKANGKVIR.W 1 2.336 0.134 O interacting protein) (smad anchor for (96%) receptor activation) (receptor activation anchor) (hsar Q16706 homo sapiens (human). SW:MAN2_HUMA alpha-mannosidase ii (ec 3.2.1.114) I.NLSPMEI.S 1 2.368 0.175 O N (mannosyl-oligosaccharide 1,3-1,6- Supplementary Table 1 263 alpha-mannosidase) (man ii) (golgi alpha-mannosidase ii). 10/2001 Y.NREIAMKISSDIKSQN.R 1 2.372 0.086 P78559 homo sapiens (human). microtubule-associated protein 1a SW:MAPA_HUMA (map 1a) (proliferation-related protein I.VLPNGKEAEISVPYLT.S 2 2.956 0.153 P N p80) [contains: map1 light chain lc2]. 10/2001 P46821 homo sapiens (human). SW:MAPB_HUMA microtubule-associated protein 1b IPI:IPI00008868.1 E.KPPKVESKEKV.M 1 2.184 0.105 G, O N (map 1b) [contains: map1 light chain (93%) lc1]. 10/2001 L.NSASILP.E 1 2.155 0.082 V.VFLNVPENLKNPEPNIKMKR.S 2 2.577 0.200 P43243 homo sapiens (human). SW:MAT3_HUMAN K.KLKKVDKIEELDQE.N 1 2.240 0.106 G matrin 3. 10/2001 P25912 homo sapiens (human), and SW:MAX_HUMAN felis silvestris catus (cat). max protein. F.QSAADKRAHHNALE.R 1 2.990 0.141 P 12/1998 O60318 homo sapiens (human). 80 SW:MC3A_HUMA kda mcm3-associated protein (ganp D.MMREQLQLSEATGTCLGER.L 2 3.105 0.085 A, G N protein). 10/2001 L.GASGLMLLLPPKMKSEDMA.E 2 2.677 0.149 P23946 homo sapiens (human). SW:MCT1_HUMA IPI:IPI00003641.1 chymase precursor (ec 3.4.21.39) P.LLLPLPLLL.P 1 2.132 0.098 O N (97%) (mast cell protease i). 10/2001 P08183 homo sapiens (human). SW:MDR1_HUMA IPI:IPI00027481.1 multidrug resistance protein 1 (p- F.DVHDVGELNTRLTDD.V 2 2.653 0.192 G N (95%) glycoprotein 1). 10/2001 P21439 homo sapiens (human). SW:MDR3_HUMA IPI:IPI00218731.1 multidrug resistance protein 3 (p- D.SYSEEGLKPDKFEGNITF.N 2 3.063 0.080 G N (95%) glycoprotein 3). 10/2001 Y.YYSGLGAGVLVAAYIQVSFWTLAAG.R 2 3.132 0.114 O15320 homo sapiens (human). SW:MEA6_HUMA meningioma-expressed antigen 6/11 L.LEGPLTLSPLL.P 1 2.626 0.160 A N (mea6) (mea11). 10/2001 2 2.868 0.137 SW:MEFV_HUMA O15553 homo sapiens (human). pyrin IPI:IPI00007367.1 R.LRRNASSAGRLQGLAGGAPG.Q 2 2.907 0.095 G N (marenostrin). 10/2001 (98%) P55081 homo sapiens (human). SW:MFA1_HUMAN microfibrillar-associated protein 1. E.DEEFQFIKK.A 1 2.182 0.096 P 10/2001 O60732 homo sapiens (human). SW:MGC1_HUMA melanoma-associated antigen c1 L.LLKYQVKQP.I 1 2.295 0.133 G, O N (mage-c1 antigen) (cancer-testis antigen ct7). 10/2001 L.QRPVSSFFSYTLA.S 1 2.209 0.081 Q14832 homo sapiens (human). SW:MGR3_HUMA IPI:IPI00000837.1 metabotropic glutamate receptor 3 A.NASFTWVASDGWGAQESIIKGSEH.V 2 2.791 0.131 A, P N (96%) precursor. 10/2001 Q.KPNARVVVLFMRSDDSR.E 2 2.210 0.165 P03971 homo sapiens (human). muellerian inhibiting factor precursor SW:MIS_HUMAN (mis) (anti-muellerian hormone) (amh) V.LYPGPGPEVTVTRAGLPGAQSLC.P 2 2.517 0.129 G, P (mullerian inhibiting substance). 10/2001 V.TVTRAGLPGAQSLCPSR.D 2 2.271 0.203 Q9npj1 homo sapiens (human). SW:MKKS_HUMA mckusick-kaufman/bardet-biedl K.EPWALLGGGCTE.T 1 1.805 0.192 A, G N syndromes putative chaperonin. 10/2001 V.LKRIVTSCYGPSG.R 1 2.136 0.134 P08253 homo sapiens (human). 72 kda type iv collagenase precursor (ec SW:MM02_HUMA IPI:IPI00027780.1 3.4.24.24) (72 kda gelatinase) (matrix R.IIGYTPDLDPETVDDAFAR.A 2 3.753 0.547 O N (95%) metalloproteinase-2) (mmp-2) (gelatinase a) (tbe-1). 10/2001 P24347 homo sapiens (human). SW:MM11_HUMA stromelysin-3 precursor (ec 3.4.24.-) H.EFGHVLGLQHTTAAKA.L 1 2.045 0.082 G N (matrix metalloproteinase-11) (mmp- 11) (st3) (sl-3). 10/2001 P45452 homo sapiens (human). SW:MM13_HUMA collagenase 3 precursor (ec 3.4.24.-) IPI:IPI00021738.1 E.FGHSLGLDHSKDPGA.L 2 2.869 0.154 G N (matrix metalloproteinase-13) (mmp- (97%) 13). 10/2001 Supplementary Table 1 264 Q92794 homo sapiens (human). IPI:IPI00023340.1 SW:MOZ_HUMAN monocytic leukemia zinc finger protein A.PMIMEIPESGSTGNISIYER.I 2 2.502 0.098 P (93%) (zinc finger protein 220). 10/2001 P11717 homo sapiens (human). cation-independent mannose-6- phosphate receptor precursor (ci man- K.SNEHDDCQVTNPSTGHLFDLSSLSGR IPI:IPI00220965.1 SW:MPRI_HUMAN 3 3.600 0.117 P 6-p receptor) (ci-mpr) (insulin-like AGFTAAYSEK.G (96%) growth factor ii receptor) (300 kda mannose 6-phosphate Q15014 homo sapiens (human). SW:MRGX_HUMA transcription factor-like protein mrgx Q.GNVDNKEYAVNEVVAGIKEY.F 2 3.702 0.092 O N (morf-related gene x protein). 10/2001 Q92887 homo sapiens (human). canalicular multispecific organic anion SW:MRP2_HUMA IPI:IPI00023868.1 transporter 1 (multidrug resistance- A.QKAFTSITLFNILRFPL.S 2 2.483 0.112 G, O N (93%) associated protein 2) (canalicular multidrug resistance protein). 10/2001 D.GVDIASIGLHDLR.E 1 2.171 0.104 O15439 homo sapiens (human). SW:MRP4_HUMA multidrug resistance-associated IPI:IPI00006675.1 L.AKTLDAGQVGLALSYALTLMGM.F 2 2.769 0.189 P N protein 4 (mrp/cmoat-related abc (95%) transporter) (moat-b). 10/2001 P20585 homo sapiens (human). dna mismatch repair protein msh3 SW:MSH3_HUMA IPI:IPI00220264.1 (divergent upstream protein) (dup) D.SERVMIITGPNMGGKSSYI.K 2 2.495 0.160 G N (93%) (mismatch repair protein 1) (mrp1). 12/1998 Y.PPVCELEK.N 1 1.986 0.082 SW:MSH4_HUMA O15457 homo sapiens (human). muts IPI:IPI00006706.1 K.GLTEEKNYGLKAAEVSSL.P 1 2.155 0.135 O, P N protein homolog 4. 10/2001 (95%) S.YFGNKRAYAENTVASNFTF.G 2 2.725 0.129 P52701 homo sapiens (human). dna mismatch repair protein msh6 (muts- SW:MSH6_HUMA IPI:IPI00004919.1 alpha 160 kda subunit) (g/t mismatch F.NAARLANLPEEVIQK.G 2 2.585 0.101 A, P N (92%) binding protein) (gtbp) (gtmbp) (p160). 10/2001 S.LVLVDEL.G 2 2.475 0.132 Q13421 homo sapiens (human). SW:MSLN_HUMA mesothelin precursor (cak1 antigen). G.FPCAEVSGLSTERVR.E 2 2.847 0.180 A N 5/2000 Q13613 homo sapiens (human). SW:MTR1_HUMA IPI:IPI00179477.1 myotubularin-related protein 1 L.GIFENLNKHAFPLSNGQALFAFS.Y 2 2.886 0.109 G, O N (99%) (fragment). 10/2001 T.AQLTSLAMLMLDSY.Y 1 2.598 0.103 P01871 homo sapiens (human). ig mu IPI:IPI00178818.1 SW:MUC_HUMAN A.PMPEPQAPGR.Y 1 1.817 0.099 A, G, O, P chain c region. 10/2001 (99%) C.VVAHEALPNR.V 2 2.709 0.277 G.SGVTTDQVQAEAK.E 2 4.178 0.337 I.CEDDWNSGERFTCTVTHTDLPSPLK.Q 3 3.721 0.106 I.PPSFASIFLTK.S 1 2.974 0.429 2 3.284 0.422 K.GVALHRPDVYLLPPAR.E 1 3.166 0.301 2 3.957 0.308 3 5.094 0.326 K.NVPLPVIAELPPK.V 1 2.112 0.106 2 2.717 0.278 K.NVPLPVIAELPPKVSVFVPPR.D 2 2.671 0.305 K.QVGSGVTTDQVQA.E 2 2.490 0.216 K.QVGSGVTTDQVQAE.A 2 3.806 0.268 K.QVGSGVTTDQVQAEAK.E 1 3.147 0.407 2 4.775 0.395 K.QVGSGVTTDQVQAEAKE.S 2 3.189 0.392 K.VSVFVPPR.D 1 2.156 0.220 2 2.843 0.361 K.YAATSQVLLPSK.D 1 2.435 0.154 2 4.553 0.341 K.YAATSQVLLPSKDVM.Q 2 3.523 0.299 K.YAATSQVLLPSKDVMQGTDEHVVCK.V 3 4.136 0.418 K.YVTSAPMPEPQAPG.R 2 3.048 0.351 K.YVTSAPMPEPQAPGR.Y 1 2.558 0.185 2 3.962 0.333 Supplementary Table 1 265 L.HRPDVYLLPPAR.E 2 2.933 0.273 N.VPLPVIAELPPK.V 2 2.692 0.222 Q.VGSGVTTDQVQAEAK.E 2 3.735 0.344 R.DGFFGNPR.K 1 1.812 0.113 2 2.670 0.339 R.EGKQVGSGVTTDQVQAEAK.E 2 5.108 0.462 3 4.612 0.325 R.GQPLSPEKYVTSAPMPEPQAPGR.Y 2 4.073 0.418 R.QIQVSWLR.E 1 1.836 0.114 2 2.375 0.214 S.GVTTDQVQAEAK.E 2 3.211 0.379 T.NISESHPNATFSAVGEASICEDDW.N 2 2.717 0.193 V.PLPVIAELPPK.V 1 2.566 0.259 Q02817 homo sapiens (human). SW:MUC2_HUMA IPI:IPI00027201.1 mucin 2 precursor (intestinal mucin 2). L.QAYAALCAQQNICLDW.R 1 2.201 0.086 G N (95%) 10/2001 P98088 homo sapiens (human). SW:MUC5_HUMA tracheobronchial mucin (tbm) (major A.LLPEVHHPGVPPGPR.G 2 2.510 0.098 G N airway glycoprotein) (fragment). 10/2001 P04220 homo sapiens (human). ig mu SW:MUCB_HUMA IPI:IPI00185089.1 heavy chain disease protein (bot). K.QVGSGVTTDEVEAEAK.E 2 2.548 0.288 A, G, O, P N (98%) 10/2001 R.VFAIPPSFASIFLTK.S 1 3.041 0.320 2 3.563 0.325 P20769 homo sapiens (human). ig mu SW:MUCM_HUMA chain c region membrane-bound T.EGEVSADEEGFENL.W 1 2.415 0.104 G N segment. 10/2001 Q9ukn7 homo sapiens (human). IPI:IPI00152380.1 SW:MY15_HUMAN myosin xv (unconventional myosin- K.SAGPTPEKPEEEATLGDPQLPA.E 2 2.493 0.106 O, P (97%) 15). 10/2001 P.LKGQSDLDVLCNL.L 1 2.864 0.154 O00160 homo sapiens (human). IPI:IPI00180660.1 SW:MY1F_HUMAN myosin if (myosin-ie) (fragment). F.LRMLFPEK.L 1 2.365 0.152 A (98%) 10/2001 Q9ulv0 homo sapiens (human). SW:MY5B_HUMA myosin vb (myosin 5b) (fragment). E.DWGYLNEDGELGLAYQGL.K 2 2.936 0.100 P N 10/2001 SW:MY5C_HUMA Q9nqx4 homo sapiens (human). IPI:IPI00016007.1 K.AEVARLSKQVKTISEFE.K 2 2.688 0.082 P N myosin vc (myosin 5c). 10/2001 (98%) SW:MY7A_HUMA Q13402 homo sapiens (human). IPI:IPI00013193.1 A.KLAFLKLIFK.W 1 1.858 0.225 A N myosin viia. 10/2001 (95%) 2 2.652 0.135 R.KEMSAKKAKEE.A 1 2.136 0.082 T.RGETVSTPLSR.E 2 2.453 0.105 Q13459 homo sapiens (human). SW:MY9B_HUMA L.EPHVFALADVAYYTMLRKRVNQCIVYP IPI:IPI00221219.1 myosin ixb (unconventional myosin- 3 4.525 0.165 A N GE.S (92%) 9b). 10/2001 P12882 homo sapiens (human). SW:MYH1_HUMA myosin heavy chain, skeletal muscle, IPI:IPI00179548.1 F.YQIMSNKKPDLIEMLLITTNP.Y 2 3.327 0.089 P N adult 1 (myosin heavy chain iix/d) (99%) (myhc-iix/d). 10/2001 P11055 homo sapiens (human). myosin heavy chain, fast skeletal SW:MYH3_HUMA IPI:IPI00003417.1 muscle, embryonic (muscle embryonic Y.CFVVDSKEEYAK.G 2 2.523 0.103 G N (92%) myosin heavy chain) (smhce). 10/2001 P12883 homo sapiens (human). SW:MYH7_HUMA IPI:IPI00022615.1 myosin heavy chain, cardiac muscle Q.QFFNHHMFVL.E 1 2.055 0.146 A N (99%) beta isoform (myhc-beta). 10/2001 T.GKLASADIETYLLEK.S 2 2.222 0.156 P35579 homo sapiens (human). myosin heavy chain, nonmuscle type SW:MYH9_HUMA IPI:IPI00030406.1 a (cellular myosin heavy chain, type a) K.SVHELEK.S 1 1.973 0.081 G N (93%) (nonmuscle myosin heavy chain-a) (nmmhc-a). 10/2001 Q9ukx3 homo sapiens (human). SW:MYHD_HUMA myosin heavy chain, skeletal muscle, D.QIIQANPLLEAFGNAKTVR.N 2 2.234 0.131 A, P N extraocular (myhc-eo). 10/2001 F.IDSKNASEKLLNSIDV.D 2 2.731 0.084 P52179 homo sapiens (human). SW:MYM1_HUMA myomesin 1 (190 kda titin-associated H.LLHAPEFII.K 1 2.044 0.173 G N protein) (190 kda connectin- Supplementary Table 1 266 associated protein). 10/2001 SW:MYO6_HUMA Q9um54 homo sapiens (human). IPI:IPI00008455.1 K.FIRELFESSTNNNKDTKQK.A 3 3.561 0.181 A N myosin vi. 10/2001 (95%) Q14324 homo sapiens (human). SW:MYPF_HUMA myosin-binding protein c, fast-type IPI:IPI00030104.1 K.GSQRWMKLNFEVFTETTYE.S 2 2.665 0.090 G N (fast mybp-c) (c-protein, skeletal (96%) muscle fast-isoform). 7/1999 P49790 homo sapiens (human). nuclear pore complex protein nup153 SW:N153_HUMAN F.SVPVAKTAELSGSSSTLEPI.I 2 2.455 0.223 G, O, P (nucleoporin nup153) (153 kda nucleoporin). 7/1999 K.AKQLSAQ.S 1 2.035 0.122 L.GDSPFYPGKTTYGGAAAAVRQSKLR.N 2 2.361 0.118 Q13454 homo sapiens (human). n33 SW:N33_HUMAN L.PTGSFPFLLLLLLLCIQLGGGQKKKE.N 3 4.177 0.137 O protein. 10/2001 P32418 homo sapiens (human). sodium/calcium exchanger 1 IPI:IPI00028450.1 SW:NAC1_HUMAN K.KALLLNELGGFTI.T 1 2.153 0.104 O precursor (na(+)/ca(2+)-exchange (94%) protein 1). 10/2001 Q14940 homo sapiens (human). sodium/hydrogen exchanger 5 SW:NAH5_HUMAN P.QVPLHLPSDPR.S 2 2.540 0.131 P (na(+)/h(+) exchanger 5) (nhe-5). 10/2001 O15394 homo sapiens (human). SW:NCM2_HUMA IPI:IPI00006214.1 neural cell adhesion molecule 2 P.KPNIIK.D 1 1.835 0.098 A N (91%) precursor (n-cam 2). 7/1998 Q9y618 h nuclear receptor co- repressor 2 (n-cor2) (silencing SW:NCR2_HUMA mediator of retinoic acid and thyroid R.PGTEQSSGSSGSSGGGGGSSSRP.A 2 2.570 0.167 A, O N hormone receptor) (smrt) (smrte) (thyroid-, retinoic-acid-receptor- associated co-represso T.EQSSGSSGSSGGGGGSSSRPASHSH 2 2.614 0.122 A.H SW:NEBU_HUMA P20929 homo sapiens (human). IPI:IPI00026247.2 K.AAKDAYKVNTNL.D 2 2.878 0.138 G, O N nebulin. 10/2001 (97%) L.VQAVKNTAMFSK.K 2 2.598 0.182 V.QSELKYK.A 2 2.557 0.085 Q99574 homo sapiens (human). SW:NEUS_HUMA neuroserpin precursor (protease L.KDVLKALGITEIFIK.D 2 2.343 0.137 O N inhibitor 12). 10/2001 Y.INKWVENNTNNLVKD.L 2 2.736 0.166 Q12968 homo sapiens (human). nuclear factor of activated t-cells, SW:NFC3_HUMAN cytoplasmic 3 (t cell transcription Y.ASMVTSSHLPQLQCR.D 2 2.530 0.132 G factor nfat4) (nf-atc3) (nf-at4) (nfatx). 10/2001 P12036 homo sapiens (human). neurofilament triplet h protein (200 kda IPI:IPI00185528.1 SW:NFH_HUMAN K.AKEDDKTLSKE.P 1 1.884 0.126 G neurofilament protein) (neurofilament (91%) heavy polypeptide) (nf-h). 10/2001 Q14494 h nuclear factor erythroid 2 related factor 1 (nf-e2 related factor 1) SW:NFL1_HUMAN (nfe2-related factor 1) (nuclear factor, A.LQNNLLSPLL.T 1 2.215 0.138 G erythroid derived 2, like 1) (transcription factor 11) (transcription O94916 homo sapiens (human). nuclear factor of activated t cells 5 (t SW:NFT5_HUMAN cell transcription factor nfat5) (nf-at5) Q.TPMLSQEQAQPPQQGLFQPQV.A 2 2.726 0.191 G (tonicity-responsive enhancer-binding protein) (tone- binding protein) (tone O43678 homo sapiens (human). nadh-ubiquinone oxidoreductase b8 SW:NI8M_HUMAN N.NFSADQVTRALENVLSGK.A 1 1.819 0.113 P subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b8) (ci-b8). 10/2001 Q13621 homo sapiens (human). bumetanide-sensitive sodium- IPI:IPI00014335.1 SW:NKC2_HUMAN (potassium)-chloride cotransporter 2 A.DIHIIGDINI.R 1 2.025 0.135 O (93%) (kidney-specific na-k-cl symporter). 10/2001 Q07444 homo sapiens (human). nkg2- SW:NKGE_HUMA IPI:IPI00179272.1 e type ii integral membrane protein. A.CASKNSSSLLSIDNEEEMK.F 2 3.101 0.169 O, P N (97%) 12/1998 V.ELNLQNASLNHQGIDKIYDCQ.G 2 2.540 0.211 SW:NME4_HUMA O15399 homo sapiens (human). A.EPPAGAF.P 1 2.009 0.087 A, G, P N glutamate [nmda] receptor subunit Supplementary Table 1 267 epsilon 4 precursor (n-methyl d- aspartate receptor subtype 2d) (nr2d) (nmdar2d) (eb11). 10/2001 C.CSAEAAPPPAKPPPPPQPL.P 1 2.341 0.186 G.SGYVWFMVGPQLAGGGGSGAPGEPP 2 2.425 0.247 L.L Q05586 homo sapiens (human). SW:NMZ1_HUMA IPI:IPI00219336.1 glutamate [nmda] receptor subunit K.IVNIGA.V 1 1.864 0.111 P N (97%) zeta 1 precursor (nr1). 10/2001 P56182 homo sapiens (human). nnp-1 protein (novel nuclear protein 1) SW:NNP1_HUMAN D.KPLLQEELGR.T 2 2.699 0.083 G (nucleolar protein nop52) (nop52) (d21s2056e). 10/2001 L.AQRLAGNEQVTRDRAVRK.L 2 2.304 0.192 O00567 homo sapiens (human). IPI:IPI00178288.1 SW:NO56_HUMAN A.LIGEAVGA.R 1 2.022 0.159 P nucleolar protein nop56. 10/2001 (99%) K.RLKKEKKRLAALALA.S 2 2.450 0.108 P51513 homo sapiens (human). SW:NOA1_HUMA onconeural ventral antigen-1 (nova-1) Q.AAATGALAAAAASANPAAAAANLLATY. 2 2.697 0.172 G N (paraneoplastic ri antigen) (ventral A neuron-specific protein 1). 10/2001 P29475 homo sapiens (human). nitric- oxide synthase, brain (ec 1.14.13.39) SW:NOS1_HUMA K.KRVSAARLLSRQNLQSPKSSRSTIFVR IPI:IPI00217225.1 (nos, type i) (neuronal nos) (n-nos) 3 3.679 0.155 A, O N LHTNGSQE.L (97%) (nnos) (constitutive nos) (nc-nos) (bnos). 10/2001 L.IRYAGYKQPDGSTLGDPANVQFTEI.C 2 2.586 0.154 Q14978 homo sapiens (human). nucleolar phosphoprotein p130 (nucleolar 130 kda protein) (140 kda SW:NP14_HUMAN P.KRKKGEKRASSPFRR.V 2 2.201 0.141 G, O nucleolar phosphoprotein) (nopp140) (nucleolar and coiled-body phosphoprotein 1). 10/2001 S.SEDDEAPSKPAGTTKNSSNKPA.V 2 2.564 0.176 O00476 homo sapiens (human). sodium-dependent phosphate IPI:IPI00014076.1 SW:NPT4_HUMAN transport protein 4 (sodium/phosphate K.APKSLPAKSSILGGQFAIW.E 1 2.248 0.186 A (99%) cotransporter 4) (na(+)/pi cotransporter 4). 10/2001 SW:NPXR_HUMA O95502 homo sapiens (human). A.CPSGAQQGDAAGAAPG.E 2 2.619 0.082 A, O N neuronal pentraxin receptor. 10/2001 H.GAGGSAGPPALPGA.P 2 2.417 0.128 O00482 homo sapiens (human). orphan nuclear receptor nr5a2 (alpha- 1-fetoprotein transcription factor) IPI:IPI00217285.1 SW:NR52_HUMAN R.SKHEKLSTFGL.M 1 2.045 0.155 G (hepatocytic transcription factor) (b1- (99%) binding factor) (cyp7a promoter binding factor) P55055 homo sapiens (human). oxysterols receptor lxr-beta (liver x SW:NRH2_HUMA receptor beta) (nuclear orphan P.TTSSLDTPLPGNGPPQPGAPSSSPTVK 3 3.577 0.167 G N receptor lxr-beta) (ubiquitously- .E expressed nuclear receptor) (nuclear receptor ner). 10/20 W.PLGADPQSRDAR.Q 1 1.997 0.093 O14786 homo sapiens (human). neuropilin-1 precursor (vascular IPI:IPI00023730.1 SW:NRP1_HUMAN R.IKPATWETGISMRFEV.Y 1 2.251 0.094 G endothelial cell growth factor 165 (95%) receptor). 10/2001 Q15738 homo sapiens (human). nad(p)-dependent steroid A.RTHLTEDTPKVNADIEKVNQNQAKRCT IPI:IPI00019407.1 SW:NSDL_HUMAN 3 4.132 0.088 A dehydrogenase (ec 1.1.1.-) (h105e3 VIG.G (97%) protein). 10/2001 P42857 homo sapiens (human). SW:NSG1_HUMA neuron specific protein family member G.FVLKNTQCIPEGLESY.Y 2 2.860 0.133 P N 1 (brain neuron cytoplasmic protein 1) (d4s234). 10/2001 P34130 homo sapiens (human). neurotrophin-5 precursor (nt-5) SW:NT5_HUMAN G.WVTDRRTAVDLRGR.E 2 2.450 0.102 A, P (neutrophic factor 5) (neurotrophin-4) (nt-4) (neutrophic factor 4). 10/2001 V.EVLGEVPAAGGSPLRQYFFETRCKAD 3 3.767 0.154 NAEEGG.P P46531 homo sapiens (human). IPI:IPI00175506.1 SW:NTC1_HUMAN neurogenic locus notch protein R.CESVINGCKGKPCKNGGTCAVAS.N 2 3.649 0.093 O, P (96%) homolog 1 precursor (translocation- Supplementary Table 1 268 associated notch protein tan-1) (fragment). 10/2001 P37198 homo sapiens (human). A.ATATATTTTSSSTTGFALNLKPLAPAGI SW:NU62_HUMAN nuclear pore glycoprotein p62 (62 kda 2 2.692 0.233 P PS.N nucleoporin). 10/2001 SW:NUCL_HUMA P19338 homo sapiens (human). F.GGRGGGRGGFGGRGGGRGGR.G 2 3.240 0.098 G, O N nucleolin (protein c23). 10/2001 L.FVKGLSEDTTEETLKESFDG.S 2 2.414 0.194 O00217 homo sapiens (human). nadh-ubiquinone oxidoreductase 23 SW:NUIM_HUMAN kda subunit precursor (ec 1.6.5.3) (ec I.YCGFCQE.A 1 2.054 0.088 P 1.6.99.3) (complex i-23kd) (ci-23kd) (tyky subunit). 7/1999 P49757 homo sapiens (human). numb SW:NUMB_HUMA IPI:IPI00103260.1 protein homolog (h-numb) (protein S.LRINELPSTMQRKTDFPI.K 2 3.394 0.107 O N (93%) s171). 10/2001 P47890 homo sapiens (human). SW:O1G1_HUMAN olfactory receptor 1g1 (olfactory E.CFLLGFSEQLEEQKPLF.G 2 2.532 0.159 A, O receptor 17-209) (or17-209). 10/2001 P.FIYSLRNQEIKSSLRKLI.W 2 3.361 0.124 Q9h205 homo sapiens (human). SW:O2G1_HUMAN L.CATITILYLLALISNGL.L 2 3.024 0.210 P olfactory receptor 2ag1 (ht3). 10/2001 SW:O7AH_HUMA O14581 homo sapiens (human). IPI:IPI00022490.1 L.ASWMIAALNSLSQSLMVL.W 2 3.386 0.090 P N olfactory receptor 7a17. 10/2001 (91%) Q9gzm6 homo sapiens (human). IPI:IPI00026323.1 SW:O8D2_HUMAN olfactory receptor 8d2 (olfactory P.MLNPLIYSLRNKDVKNALK.K 2 3.457 0.228 A, G, O (96%) receptor-like protein jcg2). 10/2001 Q9y6k5 homo sapiens (human). 2'-5'- oligoadenylate synthetase 3 (ec IPI:IPI00002405.1 SW:OAS3_HUMAN 2.7.7.-) ((2-5')oligo(a) synthetase 3) F.RTVLGLVQQHQQL.C 2 2.615 0.080 A, P (96%) (2-5a synthetase 3) (p100 oas) (p100oas). 10/2001 K.SWTDVSLLPAFDAVGQ.L 2 2.698 0.084 O94956 homo sapiens (human). SW:OATB_HUMA IPI:IPI00016553.1 organic anion transporter b (oatp-b). L.RQQDKEARTKESRSSP.A 2 3.143 0.087 P N (91%) 10/2001 Q9ukg9 homo sapiens (human). SW:OCTC_HUMA peroxisomal carnitine IPI:IPI00216895.1 K.VPGITRDSIMNYFRTESEGR.S 2 2.545 0.212 P N octanoyltransferase (ec 2.3.1.-) (cot). (99%) 10/2001 Q9ujx0 homo sapiens (human). SW:OK38_HUMAN pregnancy-induced growth inhibitor V.LIIGAGLSAADAVLYAR.H 1 2.063 0.126 G okl38. 10/2001 P23515 homo sapiens (human). SW:OMGP_HUMA IPI:IPI00011980.1 oligodendrocyte-myelin glycoprotein Q.DGMVTNTSLTSSTK.S 1 2.198 0.211 O, P N (91%) precursor. 10/2001 Q9ubm4 homo sapiens (human). IPI:IPI00002678.1 SW:OPT_HUMAN opticin precursor (oculoglycan). E.DFKGLTKLKRIDLSNNLISSIDNDA.F 3 3.799 0.185 P (92%) 10/2001 SW:ORC2_HUMA Q13416 homo sapiens (human). origin IPI:IPI00013216.1 S.KGHSASDKVQPKNNDKSEFL.S 2 2.849 0.091 G N recognition complex subunit 2. 5/2000 (94%) O43913 homo sapiens (human). origin SW:ORC5_HUMA IPI:IPI00033206.1 recognition complex subunit 5. K.ELRHLAVLNFPK.Y 1 1.856 0.082 A, P N (99%) 10/2001 L.LGVFYTVCRDLKE.L 2 2.804 0.137 P56715 homo sapiens (human). SW:ORP1_HUMA oxygen-regulated protein 1 (retinitis IPI:IPI00011044.1 A.WLLVLNLKGSMNSFCQVDAHKAT.N 2 2.722 0.264 O N pigmentosa rp1 protein) (retinitis (93%) pigmentosa 1 protein). 10/2001 L.VLNLKGSMNSFCQVDAHKAT.N 2 2.459 0.329 Q13438 homo sapiens (human). SW:OS9_HUMAN E.NPQLKQIEGLVK.E 2 3.301 0.118 G, O, P protein os-9 precursor. 10/2001 P02818 homo sapiens (human). osteocalcin precursor (gamma- SW:OSTC_HUMA carboxyglutamic acid-containing A.GAKPSGAESSKGAAFVSK.Q 1 2.342 0.100 G N protein) (bone gla-protein) (bgp). 10/2001 Q9y5p1 homo sapiens (human). SW:OXB2_HUMAN olfactory receptor 51b2 (hor5'beta3). L.MNPVIYSIKTKQIQYGIIR.L 3 3.722 0.088 P 10/2001 P42338 homo sapiens (human). phosphatidylinositol 3-kinase catalytic subunit, beta isoform (ec 2.7.1.137) IPI:IPI00031388.1 SW:P11B_HUMAN N.NKVFGEDSVGVIFK.N 1 2.323 0.092 G (pi3-kinase p110 subunit beta) (ptdins- (96%) 3-kinase p110) (pi3k) (pi3kbeta). 10/2001 Supplementary Table 1 269 Q12888 homo sapiens (human). tumor suppressor p53-binding protein IPI:IPI00029778.1 SW:P531_HUMAN S.TQEDLFDQSNK.T 2 2.849 0.127 P 1 (p53-binding protein 1) (53bp1). (92%) 10/2001 P47712 homo sapiens (human). cytosolic phospholipase a2 (cpla2) [includes: phospholipase a2 (ec IPI:IPI00026108.1 SW:PA2Y_HUMAN K.EVPFIFNQVTE.M 2 2.536 0.096 O 3.1.1.4) (cpla2) (phosphatidylcholine (98%) 2-acylhydrolase); lysophospholipase (ec 3.1.1.5)]. 10/ Q15097 homo sapiens (human). polyadenylate-binding protein 2 IPI:IPI00008524.1 SW:PAB2_HUMAN A.FGNILSCKVVCDENGSK.G 1 2.145 0.080 G (poly(a) binding protein 2) (pabp 2). (98%) 10/2001 Q99487 homo sapiens (human). platelet-activating factor SW:PAF2_HUMAN acetylhydrolase 2, cytoplasmic (ec Y.SAFCMELASRGFVVAVPEHRDRS.A 2 2.687 0.093 G 3.1.1.47) (serine dependent phospholipase a2) (hsd-pla2). 5/2000 P25105 homo sapiens (human). IPI:IPI00012730.1 SW:PAFR_HUMAN platelet activating factor receptor (paf- R.ATTDTVTEVVVPFNQIPGNSLKN.- 2 2.767 0.103 A (92%) r). 10/2001 O75914 homo sapiens (human). serine/threonine-protein kinase pak 3 IPI:IPI00027382.1 SW:PAK3_HUMAN (ec 2.7.1.-) (p21-activated kinase 3) A.KPLSSLTPLIIAAKE.A 2 3.240 0.114 P (97%) (pak-3) (beta-pak) (oligophrenin-3). 10/2001 Q13219 homo sapiens (human). pregnancy-associated plasma protein- a precursor (ec 3.4.24.-) (papp-a) D.TSLEPPLCGQTLCDNTEVIASYNQLSS IPI:IPI00001869.1 SW:PAPA_HUMAN 2 2.226 0.208 A, P (insulin-like growth factor-dependent FR.Q (99%) igf binding protein-4 protease) (igf- dependent igf R.DPPLQMDVASILHLNRKFV.D 3 3.554 0.107 Q9nrj5 homo sapiens (human). poly(a) polymerase beta (ec 2.7.7.19) (pap SW:PAPB_HUMAN beta) (polynucleotide S.QGRNSPALAVMTASVA.N 1 2.317 0.104 G adenylyltransferase beta) (testis- specific poly(a) polymerase). 10/2001 P49023 homo sapiens (human). M.LGSLQSDLNKLGVATVAKGVCGACKK. SW:PAXI_HUMAN 2 2.716 0.267 O paxillin. 10/2001 P P22413 homo sapiens (human). ectonucleotide pyrophosphatase/phosphodiesterase K.NIKVIYGPAARLRPSDVPDKYYSFNYE IPI:IPI00026558.2 SW:PC1_HUMAN 1 (plasma-cell membrane glycoprotein 3 3.676 0.136 P GI.A (97%) pc-1) [includes: alkaline phosphodiesterase i (ec 3.1.4.1); nucleotide pyr Q15365 homo sapiens (human). poly(rc)-binding protein 1 (alpha-cp1) SW:PCB1_HUMAN K.AFAMIIDKLEEDINSSMT.N 2 2.750 0.115 O, P (hnrnp-e1) (nucleic acid binding protein sub2.3). 10/2001 L.EGPPLDAYSIQ.G 1 2.088 0.173 O94913 homo sapiens (human). pre- R.FDGPHGQPGGGIRFEGPLLQQGVGMR SW:PCFB_HUMAN mrna cleavage complex ii protein 2 3.242 0.112 A FE.G pcf11 (fragment). 10/2001 Q13087 homo sapiens (human). IPI:IPI00011571.2 SW:PDA2_HUMAN protein disulfide isomerase a2 L.QDEDVATFLALA.Q 1 2.450 0.135 P (91%) precursor (ec 5.3.4.1) (pdip). 10/2001 Q14554 homo sapiens (human). protein disulfide isomerase a5 IPI:IPI00186423.1 SW:PDA5_HUMAN precursor (ec 5.3.4.1) (protein K.YDSDRTELGFTN.Y 2 2.558 0.158 G (96%) disulfide isomerase-related protein). 10/2001 Q9ulc6 homo sapiens (human). protein-arginine deiminase type i (ec IPI:IPI00008040.1 SW:PDI1_HUMAN F.GYIEAPHKSFPVVFDSP.R 2 3.330 0.277 A, O, P 3.5.3.15) (peptidylarginine deiminase (98%) i). 10/2001 Q15118 homo sapiens (human). [pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial SW:PDK1_HUMAN E.SFGVDPVTSQNVQYFLDR.F 2 2.287 0.179 A, P precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 1). 10/2001 G.FGYGLPISRLYAQYFQGDLK.L 2 2.346 0.135 P30048 homo sapiens (human). SW:PDX3_HUMAN A.LLSDLTK.Q 1 2.096 0.092 A, O mitochondrial thioredoxin-dependent Supplementary Table 1 270 peroxide reductase precursor (peroxiredoxin 3) (antioxidant protein 1) (aop-1) (mer5 protein homolog) (hbc189) (prx iii). 1 A.LLSDLTKQI.S 1 2.003 0.113 E.FKDLSLDDFK.G 2 3.051 0.087 F.KDLSLDDFK.G 2 2.774 0.094 K.DLSLDDFK.G 1 2.215 0.087 P07202 homo sapiens (human). IPI:IPI00152376.1 SW:PERT_HUMAN thyroid peroxidase precursor (ec A.QRRELEKHSLSRVICDNTGLTR.V 3 4.016 0.106 O (97%) 1.11.1.8) (tpo). 10/2001 G.GGLDPLIRGLLARPAK.L 2 2.356 0.247 P13611 homo sapiens (human). versican core protein precursor (large SW:PGCV_HUMA fibroblast proteoglycan) (chondroitin IPI:IPI00215629.1 D.VYCYVDHLDGDVFHLTVPSKF.T 2 2.584 0.154 A N sulfate proteoglycan core protein 2) (97%) (pg-m) (glial hyaluronate-binding protein) (g I.QRHLPTIRCLGNGRWAI.P 1 2.345 0.090 R.ILDSNDQATVNPVEFNTEVATPPFSLLE 3 3.798 0.171 TSNETDF.L O60760 homo sapiens (human). glutathione-requiring prostaglandin d synthase (ec 5.3.99.2) (glutathione- SW:PGD_HUMAN A.YLDIQYEDHRIEQAD.W 2 2.944 0.096 P dependent pgd synthetase) (prostaglandin-h2 d-isomerase) (hematopoietic prostaglandin P16234 homo sapiens (human). alpha SW:PGDS_HUMA platelet-derived growth factor receptor IPI:IPI00027721.1 I.LPNENEK.V 1 2.102 0.085 A N precursor (ec 2.7.1.112) (pdgf-r-alpha) (92%) (cd140a antigen). 10/2001 Q92959 homo sapiens (human). SW:PGT_HUMAN prostaglandin transporter (pgt). C.PVPCAHFLLPAIFLISFVSLIA.C 2 3.144 0.153 G 10/2001 P80108 homo sapiens (human). phosphatidylinositol-glycan-specific phospholipase d 1 precursor (ec IPI:IPI00220124.1 SW:PHL1_HUMAN K.AQYVLISPEASSR.F 2 2.917 0.080 G, O 3.1.4.50) (pi-g pld) (glycoprotein (96%) phospholipase d) (glycosyl- phosphatidylinositol specif R.IADVTSGLIGGEDGR.V 2 4.642 0.395 R.ILEGFQPSGR.F 2 2.214 0.158 R.LSGALHVYSLGSD.- 2 2.583 0.299 R.TLLLVGSPTWK.N 2 3.157 0.234 V.YFGSKQGGMSSS.P 1 2.300 0.148 P20941 homo sapiens (human). SW:PHOS_HUMA phosducin (phd) (33 kda G.KQFLETIEK.E 1 2.406 0.088 P N phototransducing protein) (meka protein). 10/2001 P11217 homo sapiens (human). glycogen phosphorylase, muscle form Q.LGLDMEELEEIEEDAGLGNGGLGRLAA IPI:IPI00178334.1 SW:PHS2_HUMAN 3 4.266 0.104 P (ec 2.4.1.1) (myophosphorylase). CFLDSMATLGLA.A (99%) 10/2001 P11216 homo sapiens (human). IPI:IPI00004358.2 SW:PHS3_HUMAN glycogen phosphorylase, brain form F.YELEPEKFQ.N 1 2.418 0.083 A (96%) (ec 2.4.1.1). 10/2001 T.GNMKFMLNGALTIGTMDGA.N 2 2.837 0.134 Q00722 homo sapiens (human). 1- phosphatidylinositol-4,5-bisphosphate IPI:IPI00215714.1 SW:PIB2_HUMAN phosphodiesterase beta 2 (ec E.EPFVFEKILMPEL.A 2 2.636 0.088 P (92%) 3.1.4.11) (plc-beta-2) (phospholipase c-beta-2). 10/2001 M.PSPEDLR.L 1 1.910 0.108 P01833 homo sapiens (human). polymeric-immunoglobulin receptor SW:PIGR_HUMAN precursor (poly-ig receptor) (pigr) D.VSLAKADAA.P 1 2.337 0.110 A [contains: secretory component]. 10/2001 Q.YLCQAGDDSNSNK.K 2 2.700 0.121 P12273 homo sapiens (human). prolactin-inducible protein precursor N.FDIPKSVRPNDEVTAVLAVQTELKECM SW:PIP_HUMAN (secretory actin-binding protein) 3 3.786 0.159 G VVKTYL.I (sabp) (gross cystic disease fluid protein 15) (gcdfp-15) (gp17). 10/2001 Supplementary Table 1 271 Q01970 homo sapiens (human). 1- phosphatidylinositol-4,5-bisphosphate IPI:IPI00010400.1 SW:PIP3_HUMAN phosphodiesterase beta 3 (ec A.KMRDKHKKEAELTEINRR.H 2 2.710 0.151 G, O (92%) 3.1.4.11) (plc-beta-3) (phospholipase c-beta-3). 10/2001 V.WKGRPPEEEPFITHGF.T 2 2.525 0.215 O14735 homo sapiens (human). cdp- diacylglycerol--inositol 3- IPI:IPI00023639.1 SW:PIS_HUMAN phosphatidyltransferase (ec 2.7.8.11) C.CPLTASSFYL.L 2 2.889 0.129 G (93%) (phosphatidylinositol synthase) (ptdins synthase) (pi synthase). 10/2001 O00750 homo sapiens (human). phosphatidylinositol 3-kinase c2 domain-containing beta polypeptide IPI:IPI00012988.1 SW:PK3B_HUMAN C.NTFNADFQTAVPGSR.K 1 2.344 0.083 A, G (ec 2.7.1.137) (phosphoinositide 3- (92%) kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) L.DSPLVR.F 1 1.825 0.083 Y.LPQLVQALKYE.C 2 2.714 0.091 P98161 homo sapiens (human). polycystin precursor (autosomal IPI:IPI00176555.1 SW:PKD1_HUMAN K.SFSASDEDLIQQVLAEGVS.S 1 2.080 0.125 O, P dominant polycystic kidney disease (94%) protein 1). 10/2001 L.HKLDQLDASRGRAIPFCGQRGR.F 2 2.769 0.122 Q9nrz7 homo sapiens (human). 1- acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) IPI:IPI00166591.1 SW:PLCC_HUMAN I.LTFLGF.V 1 2.023 0.166 A (1- agp acyltransferase 3) (1-agpat 3) (96%) (lysophosphatidic acid acyltransferase-gamma) (lpaat- Q15149 homo sapiens (human). plectin 1 (pltn) (pcn) K.DGKTTVKDLSELGSVRTLLQGSGCLAG SW:PLE1_HUMAN 3 4.113 0.285 G, O, P (hemidesmosomal protein 1) (hd1). IYLED.T 10/2001 S.KYLTCPK.T 1 1.897 0.126 T.KASLKKLRAQA.E 1 2.014 0.130 P01243 homo sapiens (human). lactogen precursor Y.HLLKDLEEGIQTLMGRLEDGSRRTGQI SW:PLL_HUMAN 3 3.893 0.232 A (choriomammotropin) (chorionic LKQTYSK.F somatomammotropin). 10/2001 P00747 homo sapiens (human). SW:PLMN_HUMA IPI:IPI00019580.1 plasminogen precursor (ec 3.4.21.7) G.EPLDDYVNTQGA.S 2 2.870 0.135 A, O, P N (93%) [contains: angiostatin]. 10/2001 G.EPLDDYVNTQGASLFSVTK.K 2 4.351 0.472 G.EPLDDYVNTQGASLFSVTKK.Q 2 3.983 0.447 H.SIFTPETNPR.A 2 2.737 0.241 K.EAQLPVIENK.V 1 2.642 0.178 2 2.748 0.236 K.LSSPAVITDK.V 1 1.899 0.210 K.VILGAHQEVNLEPHVQEIEVSR.L 2 5.868 0.379 3 5.816 0.324 K.VIPACLPSPNYVVADRTECFITGWGET 3 4.223 0.325 QGTFGAGLLK.E K.WSSTSPHRPR.F 2 3.011 0.326 P.LDDYVNTQGASLFSVTK.K 2 4.945 0.466 P.LDDYVNTQGASLFSVTKK.Q 2 2.404 0.172 R.AFQYHSK.E 2 2.223 0.139 R.HSIFTPETNPR.A 1 2.405 0.210 2 3.380 0.264 R.MRDVVLFEK.K 2 3.111 0.142 O00469 homo sapiens (human). procollagen-lysine,2-oxoglutarate 5- IPI:IPI00011745.1 SW:PLO2_HUMAN dioxygenase 2 precursor (ec F.YETLPVAINGNGPTKILLNY.F 2 3.300 0.193 A, O, P (95%) 1.14.11.4) (lysyl hydroxylase 2) (lh2). 10/2001 L.IEQNRKIIAPLVTRHGKLWSNFWGA.L 3 4.245 0.107 Q9hcl2 homo sapiens (human). glycerol-3-phosphate acyltransferase, IPI:IPI00220400.1 SW:PLSB_HUMAN K.EYLESQSQK.P 1 1.990 0.110 A mitochondrial precursor (ec 2.3.1.15) (96%) (gpat). 10/2001 P55058 homo sapiens (human). SW:PLTP_HUMAN phospholipid transfer protein precursor R.FLEQELETITIPDLR.G 2 2.625 0.320 A (lipid transfer protein ii). 10/2001 Supplementary Table 1 272 P51805 homo sapiens (human). plexin IPI:IPI00020884.1 SW:PLX4_HUMAN a3 precursor (plexin 4) D.FSVLSALNELYF.Y 2 3.023 0.176 O, P (96%) (transmembrane protein sex). 10/2001 L.VQSAHLAKPGLLLAQALGVPADE.D 2 2.743 0.200 P40967 homo sapiens (human). melanocyte protein pmel 17 precursor (melanocyte lineage-specific antigen IPI:IPI00031630.1 SW:PM17_HUMAN R.CLLHLAVIG.A 1 1.816 0.274 A gp100) (melanoma-associated me20 (92%) antigen) (me20m/me20s) (me20- m/me20-s) (95 kda melan O43490 homo sapiens (human). prominin-like protein 1 precursor IPI:IPI00012540.1 SW:PML1_HUMAN S.LKVNLNIFLLGAAGRKNLQDFAA.C 2 2.425 0.242 A, O (antigen ac133) (cd133 antigen). (94%) 10/2001 V.DVFLCSYIIDPLNL.F 1 2.532 0.084 Y.YRRMDSEDVYDDVETIPMKNMENGNN 3 3.758 0.140 .G P54277 homo sapiens (human). pms1 SW:PMS1_HUMA IPI:IPI00005541.1 protein homolog 1 (dna mismatch S.TPERSFIFINSRPVHQKDILK.L 2 2.523 0.215 O N (95%) repair protein pms1). 10/2001 Q14863 homo sapiens (human). pou domain, class 6, transcription factor 1 SW:PO61_HUMAN (mpou homeobox protein) (brain- F.KIRRLSLGLTQ.T 1 2.022 0.141 G specific homeobox/pou domain protein 5) (brn-5 protein). 10/2001 SW:PODO_HUMA Q9np85 homo sapiens (human). IPI:IPI00219955.1 R.AKAERSGGGRGRQEAGPEP.S 2 2.908 0.080 G N podocin. 10/2001 (99%) P27169 homo sapiens (human). serum paraoxonase/arylesterase 1 (ec SW:PON1_HUMA 3.1.1.2) (ec 3.1.8.1) (pon 1) (serum K.FDVSSFNPHGISTFTDEDNAMYLLVVN IPI:IPI00218732.1 3 5.563 0.472 A, G, O, P N aryldiakylphosphatase 1) (a-esterase HPDAK.S (99%) 1) (aromatic esterase 1) (k-45). 10/2001 K.GIETGSEDLEILPNGLAFISSGLK.Y 2 5.251 0.425 3 4.503 0.215 K.GIETGSEDMEILPNGLAFISSGLK.Y 2 5.326 0.345 3 3.703 0.210 K.IFFYDSENPPASEVLR.I 1 2.068 0.184 2 5.513 0.467 K.IHVYEK.H 1 2.093 0.099 K.ILLMDLNEEDPTVLELGITGSK.F 2 6.406 0.485 3 4.508 0.376 K.LLIGTVFHK.A 2 2.436 0.203 K.SFNPNSPGK.I 1 1.862 0.103 2 2.557 0.186 K.STVELFKFQEEEKSLLHLK.T 3 3.875 0.277 K.VTQVYAENGTVLQGSTVASVYK.G 2 3.609 0.264 K.YVYIAELLAHK.I 2 2.668 0.222 L.LVVNHPDAK.S 2 3.035 0.218 L.RIQNILTEEPKVTQVYAENGTV.L 2 3.155 0.159 R.IQNILTEEPK.V 2 3.477 0.196 R.VVAEGFDFANGINISPDGK.Y 2 3.004 0.090 P21128 homo sapiens (human). IPI:IPI00006995.1 SW:PP11_HUMAN placental protein 11 precursor (ec F.ALYSLCFIARPG.K 1 2.318 0.195 A (95%) 3.4.21.-) (pp11). 10/2001 P37231 homo sapiens (human). peroxisome proliferator activated IPI:IPI00220742.1 SW:PPAT_HUMAN A.SLMNKDGVLISE.G 2 2.803 0.092 A, G receptor gamma (ppar-gamma). (97%) 10/2001 H.ITPLQEQSKEV.A 2 2.539 0.103 Y.YSEKTQLYNKPHEEPSNSLMAIECR.V 2 2.763 0.089 Q00169 homo sapiens (human). phosphatidylinositol transfer protein IPI:IPI00187125.1 SW:PPI1_HUMAN G.TQENVHKLEPEAWK.H 2 2.765 0.088 O alpha isoform (ptdins transfer protein (98%) alpha) (ptdinstp) (pi-tp-alpha). 10/2001 P09874 homo sapiens (human). poly [adp-ribose] polymerase-1 (ec SW:PPOL_HUMAN 2.4.2.30) (parp-1) (adprt) (nad(+) adp- A.VKKLTVNPGTKSKLPKPVQDLIK.M 3 3.604 0.080 A, G, P ribosyltransferase-1) (poly[adp-ribose] synthetase-1). 10/2001 G.LVDIVK.G 1 1.949 0.086 K.QQVPSGESAILDRVADGMV.F 1 2.265 0.167 Supplementary Table 1 273 Q9ukk3 homo sapiens (human). vault poly(adp-ribose) polymerase (ec SW:PPOV_HUMA IPI:IPI00033423.1 2.4.2.30) (vparp) (193-kda vault D.PYKPLDITPPPDQK.A 2 2.832 0.097 A, O N (96%) protein) (parp-related/ialphai-related h5/proline-rich) (ph5p). 10/2001 Y.CGIVFSGSSLSSAQ.S 1 2.654 0.140 P50336 homo sapiens (human). SW:PPOX_HUMA IPI:IPI00031357.1 protoporphyrinogen oxidase (ec S.ELGLDSEVLPVR.G 1 1.996 0.094 G N (95%) 1.3.3.4) (ppo). 12/1998 P33172 homo sapiens (human). serine/threonine protein phosphatase SW:PPP4_HUMAN V.RYPDRITLIR.G 1 2.078 0.135 O 4 (ec 3.1.3.16) (pp4) (protein phosphatase x) (pp-x). 5/2000 O00743 homo sapiens (human). SW:PPP6_HUMAN serine/threonine protein phosphatase D.LVWSDPEDVDTWAI.S 1 2.022 0.132 A, P 6 (ec 3.1.3.16) (pp6). 12/1998 F.CDLVWSDPEDVDTWAISPRGAGWLFG 3 3.733 0.164 AK.V Q92620 homo sapiens (human). pre- SW:PR16_HUMAN mrna splicing factor atp-dependent rna F.MPGQEDIEVTSDQIVEHLEEL.E 2 2.965 0.145 A helicase prp16. 10/2001 SW:PRGR_HUMA P06401 homo sapiens (human). IPI:IPI00152591.1 R.AEATRGAGGS.S 1 1.900 0.100 O, P N progesterone receptor (pr). 10/2001 (99%) Y.SFESLPQKICLICGDEASG.C 1 2.020 0.095 SW:PRPE_HUMA P02811 homo sapiens (human). basic R.SPPGKPQGPPPQGGNQPQGPPPPPG 3 3.882 0.303 G N proline-rich peptide p-e (ib-9). 11/1995 KPQ.G P43686 homo sapiens (human). 26s IPI:IPI00020042.2 SW:PRS6_HUMAN protease regulatory subunit 6b (tat- I.LLELLNQMDGFDQNVNVKVI.M 2 2.680 0.163 P (93%) binding protein-7) (tbp-7). 7/1998 P35998 homo sapiens (human). 26s IPI:IPI00021435.1 SW:PRS7_HUMAN protease regulatory subunit 7 (mss1 N.DIALLK.I 1 1.990 1.000 P (93%) protein). 11/1997 P04070 homo sapiens (human). vitamin-k dependent protein c SW:PRTC_HUMA precursor (ec 3.4.21.69) IPI:IPI00021817.1 R.DTEDQEDQVDPR.L 2 4.340 0.355 O, P N (autoprothrombin iia) (anticoagulant (97%) protein c) (blood coagulation factor xiv). 10/2001 R.YLDWIHGHIR.D 2 3.343 0.280 P07225 homo sapiens (human). SW:PRTS_HUMAN vitamin k-dependent protein s K.EAVMDINKPGPLFKPENGLLETK.V 3 3.970 0.228 G, O, P precursor. 10/2001 K.IETISHEDLQR.Q 1 2.870 0.174 2 3.448 0.305 K.VYFAGFPR.K 2 2.476 0.136 R.KVESELIKPINPR.L 2 4.787 0.332 3 3.647 0.256 R.NNLELSTPLK.I 1 2.105 0.148 2 2.829 0.176 R.NNLELSTPLKIETISHEDLQR.Q 2 2.963 0.246 R.SFQTGLFTAAR.Q 2 3.873 0.345 Q99460 homo sapiens (human). 26s SW:PSD1_HUMAN proteasome regulatory subunit s1 (26s H.GGDIIDYLLNQLKNASNDIVRHGGSL.G 2 2.912 0.155 G proteasome subunit p112). 10/2001 Q13200 homo sapiens (human). 26s proteasome regulatory subunit s2 (26s proteasome subunit p97) (tumor G.MLSAAASLGMILLWDVDGGLTQIDKYL IPI:IPI00174992.1 SW:PSD2_HUMAN 3 4.056 0.098 A, G, O, P necrosis factor type 1 receptor YSSEDY.I (93%) associated protein 2) (55.11 protein). 7/1999 Y.KTHLENNRFGGSGSQ.V 1 2.058 0.220 Q06323 h proteasome activator complex subunit 1 (proteasome activator 28-alpha subunit) SW:PSE1_HUMAN K.TENLLGSYFPKKISEL.D 1 2.020 0.123 G (pa28alpha) (pa28a) (activator of multicatalytic protease subunit 1) (11s regulator complex alpha su Q92530 homo sapiens (human). IPI:IPI00184629.1 SW:PSF1_HUMAN proteasome inhibitor pi31 subunit E.YGSQQVADLTLNLDDY.I 1 2.167 0.149 A (99%) (hpi31). 10/2001 Q06124 homo sapiens (human). protein-tyrosine phosphatase, non- IPI:IPI00028977.1 SW:PTNB_HUMAN K.GVDCDIDVPK.T 1 2.257 0.116 P receptor type 11 (ec 3.1.3.48) (protein- (96%) tyrosine phosphatase 2c) (ptp-2c)
Supplementary Table 1 274 (ptp-1d) (sh-ptp3) (sh- ptp2) (shp-2). 10/2001 Q05209 homo sapiens (human). protein-tyrosine phosphatase, non- SW:PTNC_HUMA R.NSDGAVTQNKTNISTASATVSAATSTE IPI:IPI00012304.1 receptor type 12 (ec 3.1.3.48) (protein- 3 3.860 0.189 O N SISTRKVLPMSI.A (92%) tyrosine phosphatase g1) (ptpg1). 10/2001 P23467 homo sapiens (human). protein-tyrosine phosphatase beta IPI:IPI00011641.1 SW:PTPB_HUMAN S.DELKPEQQHPLPSYLEYR.H 2 2.726 0.099 O precursor (ec 3.1.3.48) (r-ptp- beta). (97%) 10/2001 Y.VLWVVTHSGDLSNKVTAESRTA.P 2 2.665 0.148 P23468 homo sapiens (human). protein-tyrosine phosphatase delta IPI:IPI00011642.1 SW:PTPD_HUMAN G.VPKSGEGFIDFIGQVHKTKEQF.G 2 2.772 0.094 G precursor (ec 3.1.3.48) (r-ptp- delta). (97%) 10/2001 P23469 homo sapiens (human). protein-tyrosine phosphatase epsilon R.GNETTADSNETTTTSGPPDPGASQPLL IPI:IPI00011644.1 SW:PTPE_HUMAN 3 3.501 0.110 A precursor (ec 3.1.3.48) (r-ptp- AWLLLPLLLL.L (95%) epsilon). 10/2001 P10586 homo sapiens (human). lar IPI:IPI00021426.1 SW:PTPF_HUMAN protein precursor (leukocyte antigen L.AVILIILIVIAILLFKR.K 2 2.498 0.105 G, P (96%) related) (ec 3.1.3.48). 10/2001 T.TDTRFTLTGLK.P 1 2.120 0.177 Q06710 homo sapiens (human). IPI:IPI00183926.1 SW:PX8A_HUMAN paired box protein pax-8, isoforms P.GVIGGSKPKVATPKVVEKIGDYKR.Q 2 2.592 0.111 A (98%) 8a/8b. 10/2001 P20742 homo sapiens (human). IPI:IPI00025426.1 SW:PZP_HUMAN pregnancy zone protein precursor. K.GSFALSFPVESDVAPIAR.M 2 3.130 0.083 G, O, P (96%) 10/2001 K.HQDGSYSTFGER.Y 2 3.095 0.318 K.LEAGINQLSFPLSSEPIQGSYR.V 2 5.824 0.471 R.IREEGTDLEVTANR.I 2 4.577 0.328 R.SGTHTLPVESGDMK.G 2 3.538 0.322 R.VVVQTESGGR.I 2 2.566 0.291 T.QDTVVALHALSR.Y 1 1.922 0.103 P35241 homo sapiens (human). IPI:IPI00007154.1 SW:RADI_HUMAN R.GMLREDSMMEYLKIAQ.D 2 2.983 0.129 G radixin. 10/2001 (93%) Q9y5p3 homo sapiens (human). SW:RAI2_HUMAN retinoic acid-induced protein 2. A.TEMLSQPNHPSGEVKAEN.N 2 2.449 0.133 O, P 10/2001 S.PPALANNRLENGMAQLITTEAWNINST 3 4.305 0.229 DLVK.K P11233 homo sapiens (human). ras- IPI:IPI00217519.1 SW:RALA_HUMAN V.KEDENVPFLLVGNK.S 2 2.513 0.226 P related protein ral-a. 2/1994 (92%) P29375 homo sapiens (human). SW:RBB2_HUMAN retinoblastoma-binding protein 2 K.VEPEVLSTDTQTSP.E 1 2.067 0.180 A, G (rbbp-2). 10/2001 L.EPNLFCDE.E 1 2.246 0.107 L.YVCMFCGRGNNEDKLLLCDGCDDSYH 2 2.653 0.106 .T SW:RCQ1_HUMA P46063 homo sapiens (human). atp- IPI:IPI00178431.1 A.TSRRRLQTCFSNL.V 2 2.953 0.145 O N dependent dna helicase q1. 10/2001 (97%) P78563 homo sapiens (human). double-stranded rna-specific editase 1 IPI:IPI00186962.1 SW:RED1_HUMAN (ec 3.5.-.-) (dsrna adenosine D.TLFNGF.E 1 2.242 0.098 A, O (99%) deaminase) (rna editing enzyme 1). 10/2001 F.SSSGDLSLSASPVPASLAQPPLPVLPP 3 4.027 0.098 FP.P SW:REQC_HUMA Q92784 homo sapiens (human). zinc- IPI:IPI00023321.2 I.QEIQRVLENDENVEEGNEEE.D 2 2.787 0.165 P N finger protein cer-d4. 10/2001 (91%) P30622 homo sapiens (human). restin (cytoplasmic linker protein-170 alpha- SW:REST_HUMAN 2) (clip-170) (reed- sternberg E.NQKMEEFR.K 1 1.932 0.111 O intermediate filament associated protein). 10/2001 P02753 homo sapiens (human). IPI:IPI00022420.2 SW:RETB_HUMAN plasma retinol-binding protein K.MKYWGVASFLQK.G 2 4.325 0.376 A, O, P (93%) precursor (prbp) (rbp). 10/2001 K.YWGVASFLQK.G 2 3.060 0.204 R.DPNGLPPEAQK.I 2 2.971 0.166 R.VKENFDKAR.F 2 3.038 0.160 S.VKENFDK.K 1 1.995 0.104 Supplementary Table 1 275 2 2.589 0.105 P14373 homo sapiens (human). zinc- IPI:IPI00026261.1 SW:RFP_HUMAN finger protein rfp (ret finger protein). C.EDSVCRKGGVTSAPQNGFWAV.S 2 2.996 0.151 O (92%) 10/2001 P48380 homo sapiens (human). dna- SW:RFX3_HUMAN T.YLIGNSMENSGHSVTHTTRASPATI.E 2 2.857 0.107 O binding protein rfx3. 10/2001 Q9nzl6 homo sapiens (human). ral guanine nucleotide dissociation SW:RGL1_HUMAN A.EQLTYMDAQLFKKVVP.H 1 2.285 0.189 G, P stimulator-like 1 (ralgds-like 1). 10/2001 K.IHKRSVSVTSITSTVLPPVYNQQNEDTC 3 4.030 0.158 IIR.I O14924 homo sapiens (human). SW:RGSC_HUMA IPI:IPI00186995.1 regulator of g-protein signaling 12 P.DGTSCVVAVK.A 1 2.227 0.132 P N (96%) (rgs12). 10/2001 P48552 homo sapiens (human). IPI:IPI00010196.1 SW:RI14_HUMAN nuclear factor rip140 (nuclear receptor I.TDAEKNEYEKDSPRLTKT.N 2 2.540 0.103 G, O (95%) interacting protein 1). 10/2001 L.TYLEGLLMHQAAGGSGTAVDKKSA.G 2 2.527 0.145 R.EASSAESVSQVTA.K 2 2.640 0.138 Q13671 homo sapiens (human). ras SW:RIN1_HUMAN interaction/interference protein 1 (ras S.PVELEQVRQKLLQLVRTY.S 2 3.204 0.221 G inhibitor jc99). 10/2001 Q13546 homo sapiens (human). serine/threonine protein kinase rip (ec IPI:IPI00013773.1 SW:RIP_HUMAN D.NTTSLTDKHLDPIR.E 2 2.557 0.097 G 2.7.1.-) (cell death protein rip) (98%) (receptor interacting protein). 10/2001 P46776 homo sapiens (human). 60s SW:RL2A_HUMAN P.VIVKAKFFSRRAEEKI.K 1 2.864 0.090 G ribosomal protein l27a. 10/2001 Q05823 homo sapiens (human). 2-5a- dependent ribonuclease (ec 3.1.26.-) IPI:IPI00015864.1 SW:RN5A_HUMAN K.TPLILAVEKKHLGLV.Q 1 2.027 0.150 G (2-5a-dependent rnase) (ribonuclease (96%) l) (rnase l) (ribonuclease 4). 10/2001 L.LSSDDSDVEAITHL.L 1 2.048 0.115 Q13151 homo sapiens (human). SW:ROA0_HUMA heterogeneous nuclear K.AVPKEDIYSGGGGGGSRS.S 2 3.010 0.253 A, O N ribonucleoprotein a0 (hnrnp a0). 10/2001 Y.NAYGGGGGGSSYGGSDYGNGFGGFG 2 2.411 0.102 SYS.Q Q01974 homo sapiens (human). tyrosine-protein kinase SW:ROR2_HUMA transmembrane receptor ror2 K.GQIRPMVPPPQLYVPVNGYQPVPAY.G 2 2.549 0.092 A, P N precursor (ec 2.7.1.112) (neurotrophic tyrosine kinase, receptor-related 2). 10/2001 S.HHVVHKDLATRNVLVYDK.L 2 2.615 0.199 Q92753 homo sapiens (human). SW:RORB_HUMA IPI:IPI00023259.1 nuclear receptor ror-beta (nuclear A.EVQKHQQRLQEQR.Q 2 2.829 0.175 A, O, P N (94%) receptor rzr-beta). 7/1999 I.QITHAIQYVVEFAKRITGF.M 2 2.541 0.240 K.YGGMQMFK.A 1 2.134 0.087 Q.QQSGEAEALAR.V 2 2.277 0.141 O00411 homo sapiens (human). dna- SW:RPOM_HUMA directed rna polymerase, IPI:IPI00176567.1 S.HMMLTALHCYRK.G 1 1.901 0.116 G N mitochondrial precursor (ec 2.7.7.6) (93%) (mtrpol). 10/2001 Q92737 homo sapiens (human). ras- IPI:IPI00023219.1 SW:RR22_HUMAN like protein rrp22 (ras-related protein R.PAHPALR.L 1 1.812 0.102 G (93%) on chromosome 22). 10/2001 Q9y2l1 homo sapiens (human). exosome complex exonuclease rrp44 IPI:IPI00032301.1 SW:RR44_HUMAN (ec 3.1.13.-) (ribosomal rna T.RQASTLEGR.R 1 1.987 0.102 G (95%) processing protein 44) (dis3 protein homolog). 10/2001 P39028 homo sapiens (human), mus musculus (mouse), and rattus IPI:IPI00166890.1 SW:RS23_HUMAN I.EENDEVLVAGFGRKGHA.V 1 2.282 0.096 A norvegicus (rat). 40s ribosomal protein (98%) s23. 10/2001 Q15283 homo sapiens (human). ras SW:RSG2_HUMA IPI:IPI00015811.1 gtpase-activating protein 2 (gap1m). D.VFLGEIKVPVNVLR.T 2 2.695 0.192 A, O N (91%) 10/2001 F.EVTRSSSYTRKSQFQV.E 2 2.458 0.274 O75298 homo sapiens (human). SW:RTN2_HUMAN L.LLLCGTISLRVYRKVLQAVH.R 2 3.173 0.101 P reticulon protein 2 (neuroendocrine- Supplementary Table 1 276 specific protein-like 1) (nsp-like protein 1) (nspli). 10/2001 O95197 homo sapiens (human). reticulon protein 3 (neuroendocrine- SW:RTN3_HUMAN K.SIVEKIQ.A 1 1.865 0.080 G specific protein-like 2) (nsp-like protein ii) (nsplii). 10/2001 P21817 homo sapiens (human). ryanodine receptor 1 (skeletal muscle- IPI:IPI00220559.1 SW:RYR1_HUMAN type ryanodine receptor) (ryr1) (ryr-1) P.ELEPEKADAENGEK.E 2 2.770 0.117 P (92%) (skeletal muscle calcium release channel). 10/2001 Q92736 homo sapiens (human). ryanodine receptor 2 (cardiac muscle- type ryanodine receptor) (ryr2) (ryr-2) IPI:IPI00186668.1 SW:RYR2_HUMAN A.IVAFSDDFVAK.L 2 2.284 0.110 A, P (cardiac muscle ryanodine receptor- (96%) calcium release channel) (hryr-2). 10/2001 T.DDTSDPEKTVER.V 2 2.798 0.105 Q9uee5 homo sapiens (human). serine/threonine kinase 17a (ec 2.7.1.- SW:S17A_HUMAN K.PEDRATAEECLKHP.W 2 2.808 0.142 O ) (dap kinase-related apoptosis- inducing protein kinase 1). 10/2001 Q15437 homo sapiens (human). IPI:IPI00017376.2 SW:S23B_HUMAN protein transport protein sec23b L.QAPLDDAQEILQAR.F 2 2.609 0.146 O, P (98%) (sec23-related protein b). 10/2001 Q13435 homo sapiens (human). splicing factor 3b subunit 2 SW:S3B2_HUMAN (spliceosome associated protein 145) P.VPRPPQDMGQIGVRTPLGPRV.A 2 2.428 0.171 A, G (sap 145) (sf3b150) (pre-mrna splicing factor sf3b 145 kda subunit). 10/2001 R.KGPAPELQ.G 1 2.208 0.125 Q15427 homo sapiens (human). splicing factor 3b subunit 4 IPI:IPI00182396.1 SW:S3B4_HUMAN (spliceosome associated protein 49) Q.AGPVVNTHMPK.D 2 2.882 0.166 A (92%) (sap 49) (sf3b50) (pre-mrna splicing factor sf3b 49 kda subunit). 10/2001 Q01959 homo sapiens (human). sodium-dependent dopamine IPI:IPI00219765.1 SW:S6A3_HUMAN T.LPGAIDGIR.A 1 1.980 0.118 P transporter (da transporter) (dat). (95%) 10/2001 P02735 homo sapiens (human). serum amyloid a protein precursor IPI:IPI00006146.3 SW:SAA_HUMAN R.FFGHGAEDSLADQAANEWG.R 2 4.388 0.370 A, O, P (saa) [contains: amyloid protein a (93%) (amyloid fibril protein aa)]. 10/2001 R.FFGHGAEDSLADQAANEWGR.S 2 6.684 0.458 3 5.715 0.366 P35542 homo sapiens (human). serum amyloid a-4 protein precursor SW:SAA4_HUMAN A.YWDIMISNHQNSNR.Y 2 2.202 0.230 O, P (constitutively expressed serum amyloid a protein) (c-saa). 10/2001 K.EALQGVGDMGR.A 1 2.182 0.114 2 3.743 0.333 K.SNEKAEEWGR.S 1 2.696 0.254 2 3.709 0.282 R.AYWDIMISNHQNSNR.Y 2 4.321 0.491 R.FRPDGLPK.K 1 1.839 0.237 2 2.507 0.174 R.GNYDAAQR.G 2 2.387 0.252 R.GNYDAAQRGPGGVWAAK.L 2 4.181 0.311 R.GPGGVWAAK.L 1 2.148 0.243 2 3.310 0.289 R.SFFKEALQGVGDMGR.A 2 4.020 0.291 R.VYLQGLIDYYLFGNSSTVLEDSK.S 2 3.887 0.265 SW:SACS_HUMA Q9nzj4 homo sapiens (human). IPI:IPI00021406.1 A.KDFAAKYQTIR.F 2 2.203 0.110 O, P N sacsin. 10/2001 (98%) M.TLKKIKWVPACK.E 2 2.985 0.085 P02743 homo sapiens (human). SW:SAMP_HUMA serum amyloid p-component precursor K.IVLGQEQD.S 1 1.844 0.217 G, P N (sap) (9.5s alpha-1-glycoprotein). 10/2001 K.IVLGQEQDSYGGK.F 1 2.469 0.249 2 3.857 0.296 K.IVLGQEQDSYGGKFDR.S 2 4.279 0.494 Supplementary Table 1 277 K.VFVFPR.E 1 1.990 0.179 N.ILDWQALNYEIR.G 2 3.932 0.428 R.AYSLFSYNTQGR.D 2 4.372 0.419 R.DNELLVYK.E 1 2.447 0.168 R.DNELLVYKER.V 2 3.284 0.215 R.GYVIIKPLVWV.- 2 3.808 0.270 R.QGYFVEAQPK.I 2 3.215 0.297 R.VGEYSLYIGR.H 1 1.993 0.187 2 3.502 0.373 Q9um82 homo sapiens (human). spermatogenesis associated protein 2 SW:SAT2_HUMAN V.AASTLLSLHKV.D 2 2.656 0.097 P (spermatogenesis associated protein pd1). 10/2001 P43007 homo sapiens (human). neutral amino acid transporter a (satt) SW:SATT_HUMAN A.AGPGAPGTAAGRAR.R 2 2.316 0.247 G, P (alanine/serine/cysteine/ threonine transporter) (asct1). 10/2001 L.VTATASSVGAAGVPAGGVLTIAI.I 2 2.457 0.101 Q92503 homo sapiens (human). IPI:IPI00021887.1 SW:SC14_HUMAN P.GGLLDYIDK.E 1 2.199 0.085 G sec14-like protein 1. 10/2001 (95%) Q07837 homo sapiens (human). neutral and basic amino acid transport IPI:IPI00029268.1 SW:SC31_HUMAN protein rbat (b(0,+)-type amino acid L.IFEHNTKNLLHR.Q 2 3.053 0.188 A (95%) transport protein) (nbat) (d2h). 10/2001 P18827 homo sapiens (human). SW:SDC1_HUMAN syndecan-1 precursor (synd1) (cd138 A.LPQIVATNLPPE.D 2 3.160 0.168 G antigen). 10/2001 O75056 homo sapiens (human). SW:SDC3_HUMAN A.AFLVTLLIYRMKKK.D 2 2.904 0.084 P syndecan-3 (synd3). 10/2001 P20132 homo sapiens (human). l- IPI:IPI00022201.1 SW:SDHL_HUMAN serine dehydratase (ec 4.2.1.13) (l- A.GTSVYLKMDSAQPSGSFKI.R 2 2.467 0.217 A, O (91%) serine deaminase). 10/2001 F.ELAKALAK.N 1 1.828 0.102 P.LHVKTPIRDSMALSKM.A 2 3.023 0.129 Q9ubv2 homo sapiens (human). sel-1 IPI:IPI00002790.1 SW:SE1L_HUMAN homolog precursor (suppressor of lin- K.LGVVYFLQ.Y 1 1.938 0.117 P (92%) 12-like protein) (sel-1l). 10/2001 P49908 homo sapiens (human). SW:SELP_HUMAN selenoprotein p precursor (sep). R.DMPASEDLQDLQK.K 2 3.080 0.280 O 10/2001 Q92629 homo sapiens (human). delta- SW:SGCD_HUMA sarcoglycan (sg-delta) (35 kda IPI:IPI00022505.1 K.ELRLESPTRSLVMEAPKGVE.I 2 2.673 0.146 O N dystrophin-associated glycoprotein) (94%) (35dag). 10/2001 P04278 homo sapiens (human). sex hormone-binding globulin precursor SW:SHBG_HUMA IPI:IPI00219583.1 (shbg) (sex steroid-binding protein) K.VVLSSGSGPGLDLPLVLGLPLQLK.L 2 5.151 0.493 O, P N (99%) (sbp) (testis-specific androgen-binding protein) (abp). 10/2001 3 4.315 0.306 R.IALGGLLFPASNLR.L 2 2.702 0.186 P31639 homo sapiens (human). sodium/glucose cotransporter 2 IPI:IPI00012449.1 SW:SL52_HUMAN (na(+)/glucose cotransporter 2) (low V.IVQRCLAGKSLTHIKAGCILCGYLK.L 2 2.618 0.207 A (92%) affinity sodium-glucose cotransporter). 10/2001 Q14493 homo sapiens (human). histone rna hairpin-binding protein K.YSRRSWDQQIKLWKVALHFWDPPAEE SW:SLBP_HUMAN 3 3.781 0.255 P (histone stem-loop binding protein). GC.D 10/2001 SW:SM3E_HUMA O15041 homo sapiens (human). IPI:IPI00004494.1 V.ITIYNQEM.E 1 2.083 0.160 G, P N semaphorin 3e precursor. 10/2001 (96%) Q9h3t3 homo sapiens (human). SW:SM6B_HUMA IPI:IPI00218513.1 semaphorin 6b precursor (semaphorin L.LLLAPARAPEQPPAPG.E 2 2.822 0.088 G N (94%) z) (sema z). 10/2001 R.GGGGGGGAGVPPEALLAPLMQNGWA 3 3.939 0.084 KATLLQ.G Q9h3t2 homo sapiens (human). SW:SM6C_HUMA semaphorin 6c precursor (semaphorin V.CKRDMGGSPRALDRH.W 1 2.078 0.121 G N y) (sema y). 10/2001 V.DVEKPQLSLKPPLVGPSSR.Q 2 2.444 0.135 SW:SMB2_HUMA P38935 homo sapiens (human). dna- IPI:IPI00009379.1 V.LYAGSGTKNGSLDPAKRAQLQ.R 2 3.236 0.270 O, P N binding protein smubp-2 (91%) Supplementary Table 1 278 (immunoglobulin mu binding protein 2) (smubp-2) (glial factor-1) (gf-1). 10/2001 O95721 homo sapiens (human). synaptosomal-associated protein 29 IPI:IPI00032831.1 SW:SN29_HUMAN (snap-29) (vesicle-membrane fusion R.GVLERTEKMVDK.M 2 2.241 0.110 A (93%) protein snap-29) (soluble 29 kda nsf attachment protein). 10/2001 R.LKDIALGMQTEIEEQDDI.L 2 2.582 0.101 Q9nyy3 homo sapiens (human). serine/threonine-protein kinase snk SW:SNK_HUMAN S.PAKNFFKKAAAAL.F 2 2.723 0.104 A (ec 2.7.1.-) (serum inducible kinase). 10/2001 P80697 homo sapiens (human). SW:SNSP_HUMA synovial stimulatory protein p205 V.QLVEYVDGVEVHNAK.- 2 3.106 0.122 G N (fragments). 11/1997 O95219 homo sapiens (human). IPI:IPI00029403.1 SW:SNX4_HUMAN V.YYPHIVVPPLPEKR.A 2 2.703 0.136 O sorting nexin 4. 10/2001 (93%) P01241 homo sapiens (human). SW:SOMA_HUMA IPI:IPI00022166.1 somatotropin precursor (growth F.KQTYSKFDTNSHNDDALLKNY.G 2 2.643 0.116 A N (93%) hormone). 10/2001 P18583 homo sapiens (human). son SW:SON_HUMAN A.NIEDINEADLVRPLLPK.D 2 3.313 0.214 G protein (son3). 10/2001 P36956 homo sapiens (human). sterol regulatory element binding protein-1 SW:SRE1_HUMAN E.SLYSLAGNPVDPLAQV.T 1 2.282 0.105 A, G (srebp-1) (sterol regulatory element- binding transcription factor 1). 10/2001 L.VVDAEKLPINR.L 2 2.400 0.124 P32745 homo sapiens (human). SW:SSR3_HUMAN somatostatin receptor type 3 (ss3r) E.LFMLGLPFL.A 1 2.249 0.102 O (ssr-28). 10/2001 Q15532 homo sapiens (human). ssxt protein (synovial sarcoma, R.PNMSMQPNQGPMMHQQPPSQQYNM SW:SSXT_HUMAN 3 3.910 0.170 P translocated to x chromosome) (syt PQGGGQHYQ.G protein). 10/2001 Q9y5y6 homo sapiens (human). suppressor of tumorigenicity 14 (ec 3.4.21.-) (matriptase) (membrane- F.YLLEPGVPAGTCPKDYVEINGEKYCGE IPI:IPI00001922.1 SW:ST14_HUMAN 3 3.814 0.168 P type serine protease 1) (mt-sp1) RSQFVVTSNSNKITVRF.H (94%) (prostamin) (serine protease tadg-15) (tumor associated P48723 homo sapiens (human). SW:STCH_HUMA IPI:IPI00011079.1 microsomal stress 70 protein atpase V.ELADSNPQNTIYDAK.R 1 2.155 0.087 G N (96%) core precursor. 10/2001 P09430 homo sapiens (human). SW:STP1_HUMAN spermatid nuclear transition protein 1 G.MRRSKSRSPHKGVKRGGSK.R 2 3.104 0.140 G, O, P (stp-1) (tp-1). 10/2001 Q13190 homo sapiens (human). IPI:IPI00157168.1 SW:STX5_HUMAN L.AKRKSLFDDKAVEIEELTYII.K 2 2.835 0.084 P syntaxin 5. 5/2000 (99%) P80098 homo sapiens (human). small inducible cytokine a7 precursor SW:SY07_HUMAN (monocyte chemotactic protein 3) R.RTTSSHCPRE.A 2 2.533 0.134 O (mcp-3) (monocyte chemoattractant protein 3) (nc28). 5/2000 P78423 homo sapiens (human). fractalkine precursor (neurotactin) SW:SYD1_HUMAN (cx3c membrane-anchored H.LTVLLAGQHHGVTKCNITCSK.M 2 2.260 0.170 A, G chemokine) (small inducible cytokine d1). 10/2001 R.NGGTFEKQIGEVKPRTT.P 2 2.599 0.089 P41252 homo sapiens (human). isoleucyl-trna synthetase, cytoplasmic SW:SYI_HUMAN G.ADALRLYLINSPVVRAENLRFK.E 2 2.247 0.113 A (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). 10/2001 H.QDPEALKDIKSLEK.Y 2 2.449 0.192 O43426 homo sapiens (human). synaptojanin 1 (ec 3.1.3.56) (synaptic IPI:IPI00219507.1 SW:SYJ1_HUMAN P.RTSPCQSPTISEGPVPSLPIR.P 2 2.273 0.204 A, O inositol-1,4,5-trisphosphate 5- (93%) phosphatase 1). 10/2001 Q.EVFRSMWSVNGD.S 2 3.018 0.219 P21579 homo sapiens (human). SW:SYT1_HUMAN K.VQVVVTVLDYDKIG.K 2 2.743 0.144 G synaptotagmin i (syti) (p65). 10/2001 SW:SYUB_HUMA Q16143 homo sapiens (human). beta- E.KTKQGVTEAAEKTK.E 1 2.020 0.098 G N synuclein. 10/2001 Q99816 homo sapiens (human). SW:T101_HUMAN T.GKHVDANGK.I 1 2.023 0.091 A tumor susceptibility gene 101 protein. Supplementary Table 1 279 10/2001 O14798 h tumor necrosis factor receptor superfamily member 10c precursor (decoy receptor 1) (dcr1) SW:T10C_HUMAN V.AVLLPVLAYSAT.T 1 2.289 0.080 P (decoy trail receptor without death domain) (tnf- related apoptosis- inducing ligand recep Q9y6q2 homo sapiens (human). IPI:IPI00009269.1 SW:T2AZ_HUMAN stoned b-tfiia-alpha and beta like E.NQDSLRSLSMHCLCAEENA.S 2 2.502 0.118 A, O (99%) factor (salf). 10/2001 N.IQVEIEK.K 1 1.916 0.083 Q15750 homo sapiens (human). tak1- IPI:IPI00218088.1 SW:TAB1_HUMAN A.NVGTNRALLCKSTVDGLQV.T 2 2.597 0.200 G, O, P binding protein 1. 10/2001 (97%) Q.YQKILERLK.T 1 1.828 0.127 Q01995 homo sapiens (human). transgelin (smooth muscle protein 22- IPI:IPI00216138.1 SW:TAGL_HUMAN D.MAAVQRTLMALGSLAVTK.N 2 2.623 0.108 A, G alpha) (sm22-alpha) (ws3-10) (22 kda (99%) actin-binding protein). 10/2001 V.QCGPDVGRPDR.G 2 2.615 0.082 P37837 homo sapiens (human). SW:TAL1_HUMAN Q.DNAKLVPVLSAKAA.Q 1 2.291 0.114 O transaldolase (ec 2.2.1.2). 10/2001 T.ISPKLLGELLQDNAK.L 1 2.579 0.130 Q9y490 homo sapiens (human). talin. SW:TALI_HUMAN K.AGFLDLKDFLPK.E 1 2.300 0.110 A 10/2001 P10636 homo sapiens (human). microtubule-associated protein tau SW:TAU_HUMAN E.VKSEKLDFKDRVQSKIGSLDNI.T 2 2.408 0.128 A, O (neurofibrillary tangle protein) (paired helical filament-tau) (phf-tau). 10/2001 V.SKSKDGTGSDDKK.A 2 2.393 0.166 P05217 homo sapiens (human). IPI:IPI00007752.1 SW:TBB2_HUMAN R.YLTVAAIF.R 1 1.965 0.088 P tubulin beta-2 chain. 10/2001 (95%) Y.NATLSVHQLVENTDETYCIDNE.A 2 2.485 0.180 Q9ujt0 homo sapiens (human). tubulin IPI:IPI00007119.1 SW:TBE_HUMAN epsilon chain (epsilon tubulin). L.YQDQILEKF.R 1 2.652 0.081 P (97%) 10/2001 Q9y4p3 homo sapiens (human). transducin beta-like 2 protein (ws SW:TBL2_HUMAN T.ATPEDFPKK.H 1 2.206 0.089 G, P beta-transducin repeats protein) (ws- betatrp). 10/2001 O43435 homo sapiens (human). t-box transcription factor tbx1 (t-box protein R.NHRPGALPLMSAFARSRNPVASPTQP IPI:IPI00012470.1 SW:TBX1_HUMAN 3 3.524 0.232 A 1) (testis-specific t-box protein). SGTEKGGHVLK.D (95%) 10/2001 O15119 homo sapiens (human). t-box IPI:IPI00181402.1 SW:TBX3_HUMAN transcription factor tbx3 (t-box protein L.CPSEGESDAEA.E 1 2.173 0.156 G (93%) 3). 10/2001 P01848 homo sapiens (human). t-cell IPI:IPI00102895.1 SW:TCA_HUMAN N.VSQSKDSDVYITDKTVLDMR.S 2 2.595 0.110 O receptor alpha chain c region. 10/2001 (99%) P20061 homo sapiens (human). SW:TCO1_HUMAN transcobalamin i precursor (tci) (tc i). T.YFTNVTVL.N 1 2.300 0.129 O 10/2001 Q13428 homo sapiens (human). SW:TCOF_HUMA treacle protein (treacher collins A.GEGGEASVSPEK.T 2 2.428 0.162 A, P N syndrome protein). 10/2001 K.KNPASLPLTQAALKVLAQ.K 1 2.101 0.113 P04053 homo sapiens (human). dna nucleotidylexotransferase (ec IPI:IPI00219676.1 SW:TDT_HUMAN 2.7.7.31) (terminal addition enzyme) L.SDSVTHIVAENNSGSDVLEW.L 2 2.903 0.104 O (96%) (terminal deoxynucleotidyltransferase) (terminal transferase). 10/2001 Q10587 homo sapiens (human). SW:TEF_HUMAN S.ETVSSTESSLEK.E 1 2.149 0.085 A thyrotroph embryonic factor. 10/2001 P24821 homo sapiens (human). tenascin precursor (tn) (hexabrachion) (cytotactin) (neuronectin) (gmem) (ji) IPI:IPI00031008.1 SW:TENA_HUMAN N.QYSIGNLK.P 1 1.865 0.092 O (miotendinous antigen) (glioma- (98%) associated-extracellular matrix antigen) (gp 150-2 P.VLSAEASTGETPNLGEVV.V 2 2.627 0.087 P22105 homo sapiens (human). IPI:IPI00002292.1 SW:TENX_HUMAN tenascin-x precursor (tn-x) F.LEQPLLGELTVTGVTPDSLRLSWT.V 2 2.978 0.227 G (99%) (hexabrachion-like). 10/2001 G.LAPGQEYQVTVRALRGTSWGL.P 2 2.687 0.083 K.PRLEELTVTDATPDSLSLSW.T 2 2.965 0.095 SW:TETN_HUMAN P05452 homo sapiens (human). K.NWETEITAQPDGGK.T 2 3.488 0.336 O, P Supplementary Table 1 280 tetranectin precursor (tn) (plasminogen-kringle 4 binding protein). 10/2001 R.GGTLSTPQTGSENDALYEYLR.Q 2 4.668 0.437 R.LDTLAQEVALLK.E 2 4.408 0.264 Q08188 homo sapiens (human). protein-glutamine glutamyltransferase IPI:IPI00000062.1 SW:TGL3_HUMAN A.LGKLKPNTPFAATSSMGLETEEQE.P 2 3.014 0.087 G e3 precursor (ec 2.3.2.13) (tgase e3) (96%) (transglutaminase 3). 10/2001 O43493 homo sapiens (human). trans-golgi network integral membrane IPI:IPI00012545.1 SW:TGN5_HUMAN L.PKADTNQLADK.G 2 2.730 0.105 A protein tgn51 precursor (tgn46) (92%) (tgn48) (tgn38 homolog). 10/2001 Q03167 homo sapiens (human). tgf- SW:TGR3_HUMAN beta receptor type iii precursor (tgfr-3) G.FPGDMDEGDASLF.T 2 2.864 0.180 A, G (betaglycan). 10/2001 M.GIAFAAFVIGALLTGALW.Y 1 2.279 0.103 P24557 homo sapiens (human). IPI:IPI00008967.1 SW:THAS_HUMAN thromboxane-a synthase (ec 5.3.99.5) L.RHPKPSPFIGNLTFFR.Q 1 2.459 0.138 G (96%) (txa synthase) (txs). 10/2001 P05543 homo sapiens (human). SW:THBG_HUMA IPI:IPI00009449.1 thyroxine-binding globulin precursor K.AVLHIGEK.G 1 1.882 0.101 O, P N (97%) (t4-binding globulin). 10/2001 2 2.425 0.210 K.EGQMESVEAAMSSK.T 1 2.301 0.198 2 3.921 0.502 K.NALALFVLPK.E 2 3.711 0.343 K.TEDSSSFLIDK.T 2 2.564 0.238 P00734 homo sapiens (human). SW:THRB_HUMA IPI:IPI00181119.1 prothrombin precursor (ec 3.4.21.5) A.TSEYQTFFNPR.T 2 3.817 0.432 O, P N (99%) (coagulation factor ii). 10/2001 K.ETWTANVGK.G 2 2.447 0.291 K.GQPSVLQVVNLPIVER.P 2 2.990 0.365 K.KSLEDKTER.E 2 2.622 0.258 K.KSLEDKTERELLESYIDGR.I 3 3.906 0.329 K.LAACLEGNCAEGLGTNYR.G 2 3.745 0.287 K.PGDFGYCDLNYCEEAVEEETGDGLDE 2 3.033 0.117 DSDR.A K.SLEDKTER.E 2 2.589 0.190 K.SLEDKTERELLESYIDGR.I 2 2.797 0.184 3 4.581 0.299 K.YGFYTHVFR.L 2 3.811 0.386 L.AACLEGNCAEGLGTNYR.G 2 2.604 0.110 R.DKLAACLEGNCAEGLGTNYR.G 2 4.507 0.420 R.ELLESYIDGR.I 1 2.142 0.099 2 3.405 0.293 R.ENLDRDIALMK.L 2 3.150 0.203 R.ETAASLLQAGYK.G 1 2.975 0.317 2 3.558 0.414 R.IVEGSDAEIGMSPWQVML.F 2 2.482 0.316 R.IVEGSDAEIGMSPWQVMLFR.K 2 5.973 0.539 3 6.045 0.399 R.RQECSIPVCGQDQVTVAMTPR.S 3 3.866 0.187 R.TATSEYQTFFNPR.T 1 2.082 0.109 2 4.067 0.432 R.VTGWGNLK.E 1 2.028 0.202 T.ATSEYQTFFNPR.T 2 3.927 0.347 SW:THYG_HUMA P01266 homo sapiens (human). IPI:IPI00000928.1 G.QDSPAVYLKKGQGSTTTL.Q 2 2.816 0.112 G, P N thyroglobulin precursor. 10/2001 (97%) V.AHVSTAATSN.F 1 2.020 0.168 Q13009 homo sapiens (human). t- lymphoma invasion and metastasis IPI:IPI00011400.1 SW:TIAM_HUMAN L.QKETFLTQDELDVLFGNLT.E 2 3.859 0.105 A, G, O, P inducing protein 1 (tiam1 protein). (94%) 10/2001 Q.KETFLTQDELDVLFGNLT.E 2 3.122 0.164 Y.PELEEGVELLESPPHRVD.G 2 2.488 0.208 P35590 homo sapiens (human). IPI:IPI00019530.1 SW:TIE1_HUMAN tyrosine-protein kinase receptor tie-1 T.ILAALLTLVCIR.R 1 1.887 0.085 A (96%) precursor (ec 2.7.1.112). 7/1999
Supplementary Table 1 281 2 2.435 0.101 Q13118 homo sapiens (human). transforming growth factor-beta- A.PVSPQQKSVLVSPPAVSAGGVPPMPVI SW:TIEG_HUMAN inducible early growth response 3 4.132 0.220 O CQMVPLPANNPVVTT.V protein 1 (tgfb-inducible early growth response protein 1). 10/2001 Q04726 homo sapiens (human). SW:TLE3_HUMAN transducin-like enhancer protein 3 K.PHKYQLHLHESCVLSL.K 1 2.400 0.101 G (esg3). 7/1998 P82094 homo sapiens (human). tata SW:TMF1_HUMAN element modulatory factor (tmf). E.IPKLRTQLR.D 1 2.107 0.107 O 10/2001 SW:TMOD_HUMA P28289 homo sapiens (human). IPI:IPI00002375.1 K.NNDPKLEEVNLNNIRNIPIPTLKA.Y 2 2.752 0.126 G N tropomodulin. 10/2001 (91%) O75888 homo sapiens (human). tumor necrosis factor ligand superfamily member 13 (a SW:TN13_HUMAN R.AVLTQK.Q 1 1.802 0.118 P proliferation- inducing ligand) (april) (tnf-and apol-related leukocyte expressed ligand 2) (tall-2) (tnf O95858 homo sapiens (human). IPI:IPI00000736.1 SW:TNE7_HUMAN F.RNQTIDFLNDNIR.R 2 2.939 0.119 O tetraspan net-7. 10/2001 (97%) P11388 homo sapiens (human). dna IPI:IPI00186251.1 SW:TP2A_HUMAN topoisomerase ii, alpha isozyme (ec F.VNALIENPTFDSQTKENMT.L 2 2.558 0.166 P (95%) 5.99.1.3). 10/2001 T.KLVDVVKK.K 1 1.844 0.112 P02585 homo sapiens (human). SW:TPCS_HUMAN D.MFDADGGGDISVKEL.G 1 2.574 0.202 G troponin c, skeletal muscle. 10/2001 P07226 homo sapiens (human), and sus scrofa (pig). tropomyosin, SW:TPM4_HUMAN K.LEEAEKAADESER.G 2 3.372 0.281 O fibroblast non-muscle type (tropomyosin 4) (tm30-pl). 10/2001 P12270 homo sapiens (human). IPI:IPI00018849.1 SW:TPR_HUMAN A.NDLLSATK.R 1 2.302 0.112 O, P nucleoprotein tpr. 10/2001 (99%) 2 2.884 0.102 Q9y6q6 homo sapiens (human). tumor necrosis factor receptor superfamily member 11a precursor (receptor R.CCNKCEPGKYMSSKCTTTSDSVCLPC SW:TR11_HUMAN 3 3.713 0.220 O activator of nf-kb) (osteoclast GPDEY.L differentiation factor receptor) (odfr). 10/2001 Q15628 homo sapiens (human). tumor necrosis factor receptor type 1 SW:TRAD_HUMA associated death domain protein E.ELAELEDALR.N 2 2.754 0.083 O N (tnfr1-associated death domain protein). 10/2001 P07204 homo sapiens (human). SW:TRBM_HUMA thrombomodulin precursor IPI:IPI00010737.1 H.ACNAIPGA.P 1 2.007 0.173 A N (fetomodulin) (tm) (cd141 antigen). (91%) 10/2001 P02787 homo sapiens (human). serotransferrin precursor (siderophilin) SW:TRFE_HUMAN A.GDVAFVK.H 1 2.534 0.167 A, G, O, P (beta-1-metal binding globulin). 10/2001 A.SDLTWDNLK.G 1 1.940 0.148 2 2.613 0.091 A.VPDKTVR.W 1 1.855 0.147 A.YLAPNNLKPVVAEFYGSK.E 2 3.860 0.371 D.AVTLDAGLVYDAYLAPNNLKPVVAEFY 3 4.486 0.395 GSK.E D.PQTFYYAVAVVK.K 2 3.634 0.363 D.TPEAGYFAVAVVKK.S 2 2.444 0.270 G.YEYVTAIR.N 2 2.869 0.256 H.LAQVPSHTVVAR.S 2 2.917 0.238 H.STIFENLANK.A 2 2.638 0.258 I.WELLNQAQEHFGK.D 2 3.541 0.281 I.WELLNQAQEHFGKDK.S 2 3.432 0.207 K.DGAGDVAFVK.H 1 2.460 0.238 2 3.806 0.307 K.DKSKEFQLFSSPHGK.D 3 3.654 0.180 K.DLLFKDSAHGFLK.V 2 4.230 0.299 K.DLLFKDSAHGFLKVPPR.M 2 2.542 0.221 3 5.176 0.396 Supplementary Table 1 282 K.DLLFRDDTVCLAK.L 2 3.853 0.320 K.DSAHGFLK.V 1 2.306 0.286 2 2.773 0.294 K.DSAHGFLKVPPR.M 2 3.437 0.225 K.DSGFQMNQL.R 1 2.071 0.119 K.DSGFQMNQLR.G 1 2.784 0.305 2 4.197 0.318 K.EDLIWELLN.Q 2 2.727 0.115 K.EDLIWELLNQA.Q 2 3.720 0.172 K.EDLIWELLNQAQEHFGK.D 2 5.573 0.406 K.EDLIWELLNQAQEHFGKDK.S 2 4.515 0.429 K.EDPQTFYYAVAVVK.K 1 3.130 0.274 2 4.767 0.412 3 3.850 0.301 K.EDPQTFYYAVAVVKK.D 2 3.693 0.325 K.EFQLFSSPH.G 2 2.556 0.356 K.EFQLFSSPHGK.D 1 2.965 0.355 2 3.685 0.278 K.EFQLFSSPHGKDLLFK.D 2 2.939 0.273 K.EFQLFSSPHGKDLLFKDSAHGFLK.V 3 5.635 0.403 K.EFQLFSSPHGKDLLFKDSAHGFLKVPP 3 3.515 0.405 R.M K.EGYYGYTGAFR.C 1 2.388 0.295 2 3.398 0.415 K.GDVAFVKHQTVPQNTGGK.N 2 3.598 0.320 3 3.660 0.213 K.HQTVPQNTGGK.N 1 2.154 0.123 2 2.972 0.201 K.HQTVPQNTGGKN.P 2 2.723 0.326 K.HQTVPQNTGGKNPD.P 2 3.490 0.400 K.HQTVPQNTGGKNPDPWAK.N 2 4.134 0.428 K.HSTIFENLANK.A 1 3.223 0.276 2 4.584 0.473 K.HSTIFENLANKADR.D 2 4.464 0.454 K.IMNGEADAMSLDGGFVYIAGK.C 2 4.969 0.565 K.KASYLDCIR.A 2 2.330 0.145 K.KDSGFQMNQLR.G 2 3.875 0.224 K.KSASDLTWDNLK.G 1 3.069 0.174 2 4.162 0.144 K.LCMGSGLNLCEPNNKEGYYGYTGAFR. 3 3.549 0.305 C K.LHDRNTYEK.Y 1 2.290 0.243 2 2.903 0.298 K.LHDRNTYEKYLGEEYVK.A 2 4.678 0.460 3 4.888 0.369 K.LHDRNTYEKYLGEEYVKAVGNLRK.C 3 5.219 0.419 K.MYLGYEYVTAIR.N 1 2.328 0.264 2 4.516 0.406 K.NLNEKDYELLCLDGTRKPVEEYANCHL 3 4.292 0.200 AR.A K.SASDLTWDNLK.G 1 2.869 0.326 2 3.634 0.210 K.SASDLTWDNLKGK.K 2 4.345 0.406 K.SASDLTWDNLKGKK.S 2 2.952 0.187 K.SKEFQLF.S 2 2.561 0.209 K.SKEFQLFSSPH.G 2 4.365 0.440 K.SKEFQLFSSPHG.K 2 2.957 0.221 K.SKEFQLFSSPHGK.D 1 3.941 0.352 2 4.885 0.428 3 4.263 0.362 K.SKEFQLFSSPHGKDLLFK.D 2 3.323 0.290 3 5.524 0.418 K.SKEFQLFSSPHGKDLLFKDSAHGFLK.V 3 7.177 0.560 K.SVIPSDGPSVA.C 1 1.944 0.161
Supplementary Table 1 283 K.SVIPSDGPSVACVKK.A 2 2.587 0.154 K.YLGEEYVK.A 1 2.217 0.236 2 2.632 0.151 K.YLGEEYVKAVGNLR.K 2 2.714 0.387 K.YLGEEYVKAVGNLRK.C 2 3.230 0.291 L.FKDSAHGFLK.V 2 2.537 0.251 L.GYEYVTAIR.N 2 3.304 0.323 L.NQAQEHFGK.D 2 2.393 0.190 L.NQAQEHFGKDK.S 2 3.652 0.363 M.GGKEDLIWELLNQAQEHFGK.D 3 6.046 0.423 M.SLDGGFVYIAGK.C 1 2.470 0.282 2 4.030 0.305 M.YLGYEYVTAIR.N 2 4.044 0.378 N.KEGYYGYTGAFR.C 2 3.471 0.371 N.LKPVVAEFYGSK.E 2 2.611 0.338 N.NKEGYYGYTGAFR.C 2 2.877 0.340 N.NLKPVVAEFYGSK.E 2 3.110 0.287 N.QAQEHFGK.D 2 2.236 0.177 N.QAQEHFGKDK.S 2 2.410 0.190 N.TGGKNPDPWAK.N 2 2.235 0.237 P.NHAVVTR.K 1 2.044 0.163 R.AIAANEADAVTLDAGLVYDAYLAPNNL 3 6.581 0.500 KPVVAEFYGSK.E R.APNHAVVTR.K 1 2.602 0.225 2 2.719 0.304 R.APNHAVVTRK.D 1 2.613 0.117 2 2.892 0.331 R.KPVEEYANCHLAR.A 3 3.990 0.284 R.KPVEEYANCHLARAPNHAV.V 2 3.113 0.279 R.NTYEKYLGEEYVK.A 2 4.281 0.310 R.SAGWNIPIGLLYCDLPEPR.K 2 4.611 0.388 R.SETKDLLFR.D 2 3.035 0.183 R.SMGGKEDLIWELLNQA.Q 2 3.548 0.157 R.SMGGKEDLIWELLNQAQEHFGK.D 2 5.726 0.403 3 6.568 0.369 R.SMGGKEDLIWELLNQAQEHFGKDK.S 2 4.673 0.267 3 6.361 0.345 R.TAGWNIPMGLLYNK.I 1 3.215 0.393 2 4.597 0.284 R.WCAVSEHEATK.C 2 2.630 0.174 S.ASDLTWDNLK.G 2 3.039 0.278 S.KEFQLFSSPHGK.D 1 3.537 0.379 2 4.427 0.210 3 4.098 0.310 Y.LAPNNLKPVVAEFYGSK.E 2 3.330 0.366 Y.LGYEYVTAIR.N 2 4.061 0.440 P02788 homo sapiens (human). lactotransferrin precursor (lactoferrin) IPI:IPI00022466.1 SW:TRFL_HUMAN R.LKQVLLHQQAK.F 2 4.065 0.277 G, P [contains: lactoferroxin a; lactoferroxin (96%) b; lactoferroxin c]. 10/2001 R.TAGWNIPMGLLFNQ.T 2 3.101 0.137 Q14669 homo sapiens (human). SW:TRIB_HUMAN thyroid receptor interacting protein 12 D.CLLYLEF.F 1 2.669 0.082 G, P (trip12). 10/2001 F.SSPLPGEEPIGRVEPVGNAPLL.A 2 2.512 0.110 Q16288 homo sapiens (human). nt-3 SW:TRKC_HUMA growth factor receptor precursor (ec IPI:IPI00000824.1 A.CPANCVCSKTEINCR.R 2 2.735 0.142 P N 2.7.1.112) (trkc tyrosine kinase) (96%) (gp145-trkc) (trk-c). 10/2001 O94759 homo sapiens (human). long transient receptor potential channel 2 IPI:IPI00014911.1 SW:TRL2_HUMAN P.AKRHKQLKNKLEK.N 1 2.250 0.096 G (ltrpc2) (transient receptor potential (92%) channel 7) (trpc7). 10/2001 SW:TROP_HUMA Q12816 homo sapiens (human). A.LSTAADFGGTP.S 1 2.070 0.144 A, G N trophinin. 10/2001 A.SFSGAVSTSACFSGA.P 2 2.481 0.124 G.GPPSTSACFSGATSPSF.C 2 2.873 0.115 Supplementary Table 1 284 S.KTKKAPIKTITKAAPAAPPVPA.A 2 2.815 0.177 P48995 homo sapiens (human). short IPI:IPI00012081.1 SW:TRP1_HUMAN transient receptor potential channel 1 K.EENTLNEK.L 1 2.002 0.112 A, O (93%) (trpc1) (trp-1 protein). 10/2001 V.MNSLYLATFALKVVAHNKFHDFADRK. 2 2.241 0.136 D Q9y210 homo sapiens (human). short IPI:IPI00031683.1 SW:TRP6_HUMAN transient receptor potential channel 6 A.MINSSFQEIEDDADVEWK.F 2 2.979 0.225 A (96%) (trpc6). 10/2001 Q9hcx4 homo sapiens (human). short K.DFVVGVLDLCRDTEEVEAILNGDVNFQ IPI:IPI00217327.1 SW:TRP7_HUMAN transient receptor potential channel 7 3 3.674 0.122 A VWS.D (95%) (trpc7) (trp7 protein). 10/2001 Q16881 homo sapiens (human). IPI:IPI00217352.1 SW:TRXB_HUMAN thioredoxin reductase (ec 1.6.4.5). P.GDKEYCISSDDLF.S 2 2.720 0.095 P (95%) 5/2000 P35030 homo sapiens (human). trypsin iv precursor (ec 3.4.21.4) IPI:IPI00220839.1 SW:TRY4_HUMAN D.TLDNDIMLIK.L 2 3.557 0.265 A, O, P (brain trypsinogen) (99%) (mesotrypsinogen). 10/2001 K.VLEGNEQFINAAK.I 2 2.400 0.167 Q.FINAAK.I 1 1.806 0.081 Q92574 homo sapiens (human). IPI:IPI00022043.1 SW:TSC1_HUMAN hamartin (tuberous sclerosis 1 E.DCRNMIAELRIELKKA.N 2 2.409 0.105 A, G (91%) protein). 10/2001 W.ETTMGEASASIPTTVGSLP.S 1 2.241 0.101 P98066 homo sapiens (human). tumor necrosis factor-inducible protein tsg-6 IPI:IPI00172463.1 SW:TSG6_HUMAN precursor (tnf- stimulated gene 6 S.TGNVMTLKFLSDASVTAGGFQI.K 2 2.895 0.193 A (93%) protein) (hyaluronate-binding protein). 10/2001 P53804 homo sapiens (human). IPI:IPI00023977.1 SW:TTC3_HUMAN tetratricopeptide repeat protein 3 (tpr L.NWIKYAG.D 1 2.104 0.110 A, O, P (92%) repeat protein d). 10/2001 P02766 homo sapiens (human). IPI:IPI00022432.1 SW:TTHY_HUMAN transthyretin precursor (prealbumin) A.ADDTWEPFASGK.T 2 3.788 0.343 A, G, O, P (93%) (tbpa) (ttr) (attr). 10/2001 A.ALLSPYSYSTTAVVTNPK.E 2 2.326 0.351 E.PFASGK.T 1 1.891 0.122 G.SPAINVAVHVFRK.A 2 2.981 0.360 K.AADDTWEPFASGK.T 1 2.842 0.422 2 4.591 0.455 K.ALGISPFHEHAEVVFTANDSGPR.R 2 5.584 0.532 3 4.998 0.361 K.TSESGELHGLTTEEEFVEGIYK.V 2 5.680 0.451 3 5.886 0.423 K.TSESGELHGLTTEEEFVEGIYKVEIDTK. 2 3.896 0.408 S 3 6.348 0.532 K.VLDAVRGSPAINVAVHVFR.K 3 5.912 0.347 K.VLDAVRGSPAINVAVHVFRK.A 2 2.924 0.357 3 5.303 0.343 K.VLDAVRGSPAINVAVHVFRKAADDTWE 3 4.735 0.394 PFASGK.T R.GSPAINVAVHVFR.K 2 4.429 0.451 R.GSPAINVAVHVFRK.A 1 1.914 0.113 2 4.578 0.488 R.GSPAINVAVHVFRKAADDTWEPFASG 3 4.025 0.414 K.T R.KAADDTWEPFASGK.T 1 3.230 0.312 2 5.368 0.520 R.RYTIAALLSPYSYSTTAVVTNPK.E 2 4.597 0.357 3 4.371 0.310 R.RYTIAALLSPYSYSTTAVVTNPKE.- 2 5.897 0.460 R.YTIAALLSPYSYSTTAVVTNPK.E 2 4.657 0.414 3 3.610 0.348 R.YTIAALLSPYSYSTTAVVTNPKE.- 2 5.851 0.480 Y.STTAVVTNPKE.- 2 2.942 0.327 Y.SYSTTAVVTNPK.E 2 2.459 0.386 Y.SYSTTAVVTNPKE.- 2 3.776 0.367 SW:TXTP_HUMAN P53007 homo sapiens (human). T.IKVKFIHDQTSPNPK.Y 2 2.984 0.125 G Supplementary Table 1 285 tricarboxylate transport protein, mitochondrial precursor (citrate transport protein) (ctp) (tricarboxylate carrier protein). 10/2001 P40126 homo sapiens (human). dopachrome tautomerase precursor IPI:IPI00177374.1 SW:TYR2_HUMAN (ec 5.3.3.12) (dt) (dct) (dopachrome Q.FPRVCMTVDSLVNK.E 2 2.629 0.095 A (98%) delta-isomerase) (tyrosinase-related protein 2) (trp-2) (trp2). 10/2001 Q13432 homo sapiens (human). unc- SW:U119_HUMAN 119 protein homolog (retinal protein 4) Y.DFPPLSEELISE.M 2 2.749 0.128 P (hrg4). 10/2001 Q12980 homo sapiens (human). S.AMADGNEGPQSPFHHILPKCKLARDLK IPI:IPI00015782.1 SW:U171_HUMAN cgthba protein (-14 gene protein). 3 3.895 0.212 O .E (91%) 10/2001 P57075 homo sapiens (human). IPI:IPI00025707.1 SW:UAS3_HUMAN S.LLEPLLAMGFPVHTALK.A 1 2.339 0.096 G ubash3a protein. 10/2001 (95%) P22314 homo sapiens (human). IPI:IPI00026119.2 SW:UBA1_HUMAN ubiquitin-activating enzyme e1 (a1s9 R.GLGVEIAKNIILGGVK.A 2 3.089 0.172 G (97%) protein). 10/2001 O94782 homo sapiens (human). ubiquitin carboxyl-terminal hydrolase 1 IPI:IPI00014989.1 SW:UBP1_HUMAN (ec 3.1.2.15) (ubiquitin thiolesterase 1) L.ELDKGNFVVDQM.C 1 2.442 0.087 A, O (98%) (ubiquitin-specific processing protease 1) (deubiquitinating enzyme 1) (hubp) L.FQGQLVLR.T 1 1.933 0.091 Q13107 homo sapiens (human). ubiquitin carboxyl-terminal hydrolase 4 IPI:IPI00011836.1 SW:UBP4_HUMAN (ec 3.1.2.15) (ubiquitin thiolesterase 4) T.QKSELGPLMRTTLQRGAQWY.L 2 3.195 0.091 P (91%) (ubiquitin-specific processing protease 4) (deubiquitinating enzyme 4) (ubiqu P40818 homo sapiens (human). ubiquitin carboxyl-terminal hydrolase 8 I.EAHLPDDSKDTWKKRGNVEYVVLLDWF IPI:IPI00030915.1 SW:UBP8_HUMAN (ec 3.1.2.15) (ubiquitin thiolesterase 8) 3 3.807 0.195 O S.S (91%) (ubiquitin-specific processing protease 8) (deubiquitinating enzyme 8). 10/20 Q92995 homo sapiens (human). ubiquitin carboxyl-terminal hydrolase SW:UBPD_HUMA 13 (ec 3.1.2.15) (ubiquitin IPI:IPI00024401.1 S.FPEYLVVQIKK.F 2 3.243 0.164 A N thiolesterase 13) (ubiquitin-specific (92%) processing protease 13) (deubiquitinating enzyme 13) (i O94966 homo sapiens (human). ubiquitin carboxyl-terminal hydrolase 19 (ec 3.1.2.15) (ubiquitin K.ENSTASEVLDSLSQSVHVKPENLRLAE. IPI:IPI00180140.1 SW:UBPJ_HUMAN 3 3.744 0.130 A, G, P thiolesterase 19) (ubiquitin-specific V (97%) processing protease 19) (deubiquitinating enzyme 19) (f N.LDLSKFCI.G 1 2.137 0.100 Q.CKQHREASKQLLLWRLPNVLIVQL.K 2 2.712 0.112 R.ALWKGTHHAFQPSKLK.A 1 1.824 0.172 O14957 homo sapiens (human). SW:UCRY_HUMA ubiquinol-cytochrome c reductase L.ILDWVPYINGKFK.K 1 1.906 0.226 O N complex 6.4 kda protein (ec 1.10.2.2) (complex iii subunit xi). 10/2001 Q16851 homo sapiens (human). utp-- glucose-1-phosphate IPI:IPI00186162.1 SW:UDP2_HUMAN uridylyltransferase 2 (ec 2.7.7.9) (udp- L.RLVEIAQVPKAHVDEFKSVSK.F 2 2.612 0.100 A (94%) glucose pyrophosphorylase 2) (udpgp 2) (ugpase 2). 7/1999 P07911 homo sapiens (human). SW:UROM_HUMA IPI:IPI00185918.1 uromodulin precursor (tamm-horsfall F.ALLMTNCYATPSSNA.T 2 2.590 0.183 A, O, P N (96%) urinary glycoprotein) (thp). 5/2000 I.NFACSYPLDMK.V 1 1.920 0.117 P38607 homo sapiens (human). vacuolar atp synthase catalytic subunit a, osteoclast isoform (ec 3.6.1.34) (v- SW:VAA2_HUMAN I.SGRLAEMPADSGYPAYLGARLA.S 2 2.467 0.192 O, P atpase a subunit 2) (vacuolar proton pump alpha subunit 2) (v-atpase 69 kda subu R.EASIYTGITLSEYF.R 2 2.449 0.152 Q9ukw4 homo sapiens (human). vav- IPI:IPI00007838.1 SW:VAV3_HUMAN S.LDYISKTKEDVK.L 1 1.909 0.114 P 3 protein. 10/2001 (95%) P31025 homo sapiens (human). von SW:VEGP_HUMA IPI:IPI00009650.1 ebner's gland protein precursor (veg D.PKNNLEALEDFEKAAGAR.G 3 5.456 0.485 G, P N (92%) protein) (tear prealbumin) (tp) (tear Supplementary Table 1 286 lipocalin) (lipocalin-1). 10/2001 K.AVLEKTDEPGK.Y 2 2.671 0.226 K.LVGRDPKNNLEALEDFEKAAGAR.G 3 3.772 0.247 P35968 homo sapiens (human). vascular endothelial growth factor SW:VGR2_HUMA receptor 2 precursor (ec 2.7.1.112) IPI:IPI00021396.1 I.PLEEPEVKVIPDDNQTDS.G 2 3.907 0.102 G N (vegfr-2) (kinase insert domain (97%) receptor) (protein-tyrosine kinase receptor flk-1). 10/2 P09327 homo sapiens (human). villin IPI:IPI00059396.1 SW:VIL1_HUMAN S.TQVEVQNDGAESAVF.Q 2 2.606 0.142 P 1. 10/2001 (99%) P49754 homo sapiens (human). IPI:IPI00215972.1 SW:VP41_HUMAN vacuolar assembly protein vps41 K.EQDDGELWEDLIL.Y 1 2.123 0.108 A, P (97%) homolog (s53). 10/2001 R.KCQKILGKNAAL.W 1 1.964 0.095 Q93050 homo sapiens vacuolar proton translocating atpase 116 kda subunit a isoform 1 (clathrin-coated IPI:IPI00004022.1 SW:VPP1_HUMAN S.MYTGLIYNDCFSKSLNIFGSSW.S 2 3.255 0.209 G vesicle/synaptic vesicle proton pump (95%) 116 kda subunit) (vacuolar proton pump subunit 1) P02774 homo sapiens (human). vitamin d-binding protein precursor IPI:IPI00022444.1 SW:VTDB_HUMAN K.AKLPEATPTELAK.L 2 3.448 0.237 A, G, O, P (dbp) (group-specific component) (gc- (95%) globulin) (vdb). 10/2001 K.EDFTSLSLVLYSR.K 2 2.552 0.238 K.EFSHLGKEDFTSLSLVLYSR.K 3 3.567 0.302 K.ELSSFIDK.G 1 2.162 0.166 K.HLSLLTTLSNR.V 2 4.062 0.314 K.KELSSFIDK.G 2 2.482 0.182 K.LAQKVPTADLEDVLPLAEDITNILSK.C 3 5.578 0.439 K.LPEATPTELAK.L 1 2.449 0.298 2 3.116 0.225 K.VMDKYTFELSR.R 2 3.839 0.307 K.VPTADLEDVLPLAEDITNILSK.C 2 5.157 0.387 3 6.261 0.429 K.YTFELSR.R 1 2.204 0.197 2 2.235 0.170 L.ERGRDYEKNKVCKEFSHLGKEDFTSLS 3 3.804 0.194 LVLYSR.K P.SGTFEQVSQLVK.E 2 3.394 0.275 P.TADLEDVLPLAEDITNILSK.C 2 3.699 0.265 R.KFPSGTFEQVSQLVK.E 2 4.759 0.457 3 3.974 0.206 R.RTHLPEVFLSK.V 1 2.632 0.185 2 3.708 0.338 3 3.705 0.240 R.THLPEVFLSK.V 1 2.719 0.268 2 2.852 0.380 T.HLPEVFLSK.V 1 2.276 0.102 2 2.885 0.271 V.MDKYTFELSR.R 2 2.586 0.194 P04004 homo sapiens (human). SW:VTNC_HUMA vitronectin precursor (serum spreading IPI:IPI00021729.1 A.LALPAHSYSGR.E 2 2.387 0.221 A, G, O, P N factor) (s-protein) [contains: (98%) somatomedin b]. 10/2001 F.QHQPSQEECEGSSLSAV.F 2 3.011 0.169 K.AVRPGYPK.L 2 2.595 0.181 K.GNPEQTPVLKPEEEAPAPEVGA.S 2 3.972 0.306 K.GNPEQTPVLKPEEEAPAPEVGAS.K 2 3.569 0.358 K.GNPEQTPVLKPEEEAPAPEVGASK.P 2 4.049 0.428 3 4.628 0.310 K.GNPEQTPVLKPEEEAPAPEVGASKPE 3 3.609 0.383 GID.S K.GNPEQTPVLKPEEEAPAPEVGASKPE 2 4.050 0.436 GIDSR.P 3 5.328 0.444 K.LIRDVWGIEGPIDAAFTR.I 2 2.678 0.259 N.PEQTPVLKPEEEAPAPEVGASKPEGID 3 5.319 0.501 Supplementary Table 1 287 SR.P N.VDAALALPAHSYSGR.E 2 2.596 0.197 Q.VGGPSLTSDLQAQ.S 2 3.042 0.307 Q.VGGPSLTSDLQAQSK.G 2 4.154 0.445 R.DVWGIEGPIDAAFT.R 2 3.745 0.386 R.DVWGIEGPIDAAFTR.I 1 2.928 0.284 2 4.242 0.439 R.DWHGVPGQVDAA.M 1 3.214 0.381 2 2.935 0.301 R.DWHGVPGQVDAAMAGR.I 2 3.563 0.286 3 3.725 0.216 R.FEDGVLDPDYPR.N 2 4.260 0.370 R.IYISGMAPR.P 2 3.101 0.317 R.IYISGMAPRPSLAK.K 2 3.545 0.319 R.RVDTVDPPYPR.S 1 2.616 0.262 2 2.368 0.132 R.VDTVDPPYPR.S 2 3.165 0.375 P04275 homo sapiens (human). von IPI:IPI00023014.1 SW:VWF_HUMAN willebrand factor precursor (vwf). K.YAGSQVASTSEVLK.Y 2 3.950 0.370 O, P (96%) 10/2001 R.EGGPSQIGDALGFAVR.Y 2 3.654 0.342 R.EQAPNLVYMVTGNPASDEIK.R 2 2.819 0.343 R.HIVTFDGQNFK.L 2 2.314 0.108 R.IGWPNAPILIQDFETLPR.E 2 4.495 0.463 3 3.756 0.176 R.ILAGPAGDSNVVK.L 2 3.092 0.247 R.LPGDIQVVPIGVGPNANVQELER.I 2 3.788 0.331 R.SKEFMEEVIQR.M 2 3.417 0.407 R.YLSDHSFLVSQGDREQAPNLVYMVTG 3 3.800 0.202 NPASDEIK.R R.YLTSEMHGAR.P 2 2.393 0.218 R.YLTSEMHGARPGASK.A 2 3.204 0.454 O00401 homo sapiens (human). SW:WASL_HUMA IPI:IPI00011676.1 neural wiskott-aldrich syndrome D.RNCMWSKKCSGVACLVK.D 1 2.266 0.122 G N (92%) protein (n-wasp). 10/2001 SW:WN3A_HUMA P56704 homo sapiens (human). wnt- IPI:IPI00011023.1 R.DRTCNVSSHGIDGCDLLCCGR.G 2 2.601 0.224 A, O, P N 3a protein (fragment). 10/2001 (92%) P09544 homo sapiens (human). wnt-2 SW:WNT2_HUMA protein precursor (irp protein) (int-1 D.NIDYGIK.F 1 1.908 0.111 P N related protein). 10/2001 Q01831 homo sapiens (human). dna- repair protein complementing xp-c SW:XPC_HUMAN cells (xeroderma pigmentosum group V.KWFIGTFTVNAEL.S 2 2.410 0.160 A, O c complementing protein) (p125). 10/2001 W.FIGTFTVNAELSASEQDNLQTTLERR.F 3 3.756 0.218 Q15397 homo sapiens (human). IPI:IPI00220821.1 SW:Y020_HUMAN hypothetical protein kiaa0020. L.AAFDCIDDTKLVKQIIISEII.S 3 4.602 0.179 A (97%) 10/2001 S.FKGHVRKMLRHAEA.S 1 2.866 0.115 Q15032 homo sapiens (human). SW:Y029_HUMAN hypothetical protein kiaa0029. K.DDKGEDFQ.K 1 2.380 0.118 A, P 10/2001 N.KFKLRTSKK.H 1 2.120 0.102 P42285 homo sapiens (human). IPI:IPI00030940.2 SW:Y052_HUMAN hypothetical protein kiaa0052 E.LDPLYVVEVLL.R 2 2.618 0.186 A, P (91%) (fragment). 10/2001 G.KRFDGKLQSESTNNGK.N 1 2.652 0.107 G.LKKVIQK.V 1 1.979 1.000 R.LGFATSSDVIEMKGRVACE.I 2 3.123 0.220 P42694 homo sapiens (human). IPI:IPI00000897.1 SW:Y054_HUMAN hypothetical protein kiaa0054. A.DQLFTQSVLDKS.L 2 2.816 0.114 G, O, P (98%) 10/2001 A.DQLFTQSVLDKSLTKS.N 2 2.858 0.080 A.DQLFTQSVLDKSLTKSN.Y 2 3.112 0.107 P42695 homo sapiens (human). IPI:IPI00000899.1 SW:Y056_HUMAN hypothetical protein kiaa0056 L.KDFFAVDKQLASELEY.D 2 2.911 0.115 A (95%) (fragment). 10/2001 SW:Y064_HUMAN Q15036 homo sapiens (human). V.LVNVLTSDQTEDVLEAVAA.K 2 3.155 0.174 G, P Supplementary Table 1 288 hypothetical protein kiaa0064 (ha1355). 10/2001 Q14999 homo sapiens (human). IPI:IPI00001690.1 SW:Y076_HUMAN hypothetical protein kiaa0076 C.ILHLLGKGTL.R 1 2.153 0.084 P (91%) (ha0936). 10/2001 Q15050 homo sapiens (human). IPI:IPI00014253.2 SW:Y112_HUMAN hypothetical protein kiaa0112 G.KRKGGPPSQGGKRK.G 2 2.399 0.109 A, G (93%) (ha0609) (fragment). 10/2001 R.KGGPPSQGGKRKGGLGG.K 1 1.948 0.139 Q14689 homo sapiens (human). K.MIVEVSKSACVLTTQAVTRLLRSKEAAA IPI:IPI00179952.1 SW:Y184_HUMAN hypothetical protein kiaa0184 3 3.717 0.106 O AVDIR.T (98%) (fragment). 5/2000 T.LELRGMRYHPI.D 1 2.198 0.173 Q12768 homo sapiens (human). IPI:IPI00221311.1 SW:Y196_HUMAN hypothetical protein kiaa0196. E.GVYIQQTLETV.L 2 3.148 0.101 G, P (95%) 10/2001 T.FLKLASALDLPLLRINQANSPDLL.S 2 2.595 0.113 Q12769 homo sapiens (human). IPI:IPI00221235.1 SW:Y197_HUMAN A.YSPTMGLY.L 1 2.428 0.186 G, O, P protein kiaa0197 (fragment). 10/2001 (94%) W.LSSDGEALFALPCA.S 2 2.661 0.110 Q92610 homo sapiens (human). L.APANLLPKAVHLANLNLVPHSVAASVTA SW:Y211_HUMAN hypothetical zinc finger protein 2 2.587 0.084 A K.S kiaa0211. 10/2001 O15040 homo sapiens (human). H.VAKGSLIGTYWNHVVPRGTASATKWA IPI:IPI00004493.1 SW:Y297_HUMAN hypothetical protein 3 3.615 0.094 A, G FVLASAAPTK.E (97%) kiaa0297/kiaa0329. 10/2001 N.IIRISSRPEGLTS.T 2 3.204 0.206 O15078 homo sapiens (human). SW:Y373_HUMAN hypothetical protein kiaa0373. D.QSQKESQCLK.S 2 2.827 0.136 O 10/2001 L.KAHLGHQLSMHYESK.T 1 2.007 0.190 O43303 homo sapiens (human). IPI:IPI00011933.1 SW:Y419_HUMAN hypothetical protein kiaa0419. K.ESEELLKSKMLAFEE.M 1 2.221 0.099 A, G, P (94%) 10/2001 N.SFEKVKRRLDLDIDGLQK.E 2 2.970 0.191 R.QQMDTPMVSCGNEQFLD.N 2 2.686 0.136 O43312 homo sapiens (human). SW:Y429_HUMAN hypothetical protein kiaa0429. P.GPYDQPLVNTLQR.R 1 2.274 0.151 O, P 10/2001 O60268 homo sapiens (human). IPI:IPI00028516.1 SW:Y513_HUMAN hypothetical protein kiaa0513. R.GDAGEEEEKREKW.C 2 2.633 0.081 A (91%) 10/2001 O75123 homo sapiens (human). SW:Y628_HUMAN hypothetical zinc finger protein D.FIHYSGLIEHQR.V 1 2.091 0.198 G kiaa0628. 10/2001 Q9y2g4 homo sapiens (human). IPI:IPI00186838.1 SW:Y957_HUMAN hypothetical protein kiaa0957. K.AGANVLAKNK.A 1 2.335 0.100 A (99%) 10/2001 V.SAGDTPSSEQAVAR.K 2 2.672 0.091 O60813 homo sapiens (human). IPI:IPI00032232.1 SW:YA06_HUMAN hypothetical protein dj845o24.5 K.WILPILTQFT.P 2 2.672 0.090 O, P (97%) (fragment). 5/2000 Q9y2l6 homo sapiens (human). SW:YA13_HUMAN hypothetical protein kiaa1013 D.IQDKVKPRKL.F 1 2.168 0.148 O, P (fragment). 10/2001 Q9upw6 homo sapiens (human). SW:YA34_HUMAN hypothetical protein kiaa1034. A.SQSLLVNLRAMQNFLNLPEVERD.R 2 2.847 0.114 P 10/2001 R.DVIYEEESRHHHSERMQHVVQLPPEP. 3 3.507 0.143 V Q9uls5 homo sapiens (human). IPI:IPI00008364.1 SW:YB45_HUMAN hypothetical protein kiaa1145 A.VILEELR.E 2 2.609 0.136 O (95%) (fragment). 10/2001 Q9p2q2 homo sapiens (human). IPI:IPI00100426.1 SW:YC94_HUMAN hypothetical protein kiaa1294 K.ESWRGGGGDEGDTGRLTPS.R 2 2.968 0.301 P (99%) (fragment). 10/2001 Q9p2g3 homo sapiens (human). IPI:IPI00218447.1 SW:YD84_HUMAN hypothetical protein kiaa1384 R.NETGYLSSVECYNLET.N 3 3.535 0.131 A (91%) (fragment). 10/2001 Q9nx95 homo sapiens (human). SW:YE72_HUMAN hypothetical protein kiaa1472. L.SALVVDLTPR.N 1 1.858 0.121 G, O 10/2001 2 2.335 0.150 Q9hcm4 homo sapiens (human). IPI:IPI00155430.1 SW:YF48_HUMAN K.ESLETLMLITPA.D 2 2.931 0.109 A, O hypothetical protein kiaa1548. (98%) Supplementary Table 1 289 10/2001 V.TSSGPILAEEAVLKQKCLLTTE.L 2 2.622 0.152 P52739 homo sapiens (human). zinc SW:Z131_HUMAN I.SERLVTEEVLSVETRVQTEPV.T 2 2.981 0.096 G finger protein 131 (fragment). 10/2001 P51786 homo sapiens (human). zinc IPI:IPI00215646.1 SW:Z157_HUMAN H.QRMHSGEKPYECSECGKIFSMK.K 3 3.612 0.202 O finger protein 157 (hzf22). 10/2001 (93%) Q9ulx5 homo sapiens (human). zinc SW:Z179_HUMAN finger protein 179 (brain finger D.QTLEALEAELQATAKAFMDSYTMRF.C 3 4.130 0.217 G protein). 10/2001 P98182 homo sapiens (human). zinc IPI:IPI00024329.1 SW:Z200_HUMAN K.EDDSSVGEMMLLAVNGSNPEGE.D 2 2.523 0.101 O finger protein 200. 10/2001 (97%) O95201 homo sapiens (human). zinc IPI:IPI00029377.1 SW:Z205_HUMAN finger protein 205 (zinc finger protein V.GQRVQTSSVAALGNVK.P 1 2.342 0.214 P (93%) 210). 10/2001 Q13398 homo sapiens (human). zinc SW:Z211_HUMAN finger protein 211 (zinc finger protein K.ACTRRCNLIQHQKVHS.E 1 2.572 0.111 G, P c2h2-25). 10/2001 L.IKHLRVHTGER.P 2 2.281 0.120 Q9p2y4 homo sapiens (human). zinc SW:Z219_HUMAN E.AEPLDLSLR.A 1 2.393 0.264 A, O, P finger protein 219. 10/2001 Q9ul36 homo sapiens (human). zinc IPI:IPI00020023.1 SW:Z236_HUMAN V.MTSQGLVSPSGGPHEITLTINN.S 2 2.741 0.175 G finger protein 236. 10/2001 (93%) Q9y2x9 homo sapiens (human). zinc finger protein 281 (zinc finger dna SW:Z281_HUMAN binding protein 99) (transcription factor E.MPTVSSSGGIIGTGIDELQK.R 2 3.028 0.191 O zbp-99) (gc-box-binding zinc finger protein 1). 10/2001 O94822 homo sapiens (human). zinc IPI:IPI00015593.2 SW:Z294_HUMAN V.NRGLSAQ.S 1 2.026 1.000 G finger protein 294. 10/2001 (92%) P25311 homo sapiens (human). zinc- alpha-2-glycoprotein precursor (zn- IPI:IPI00166729.1 SW:ZA2G_HUMAN D.PPSVVVTSHQAPGEK.K 2 4.235 0.483 O, P alpha-2-glycoprotein) (zn-alpha-2-gp). (97%) 10/2001 K.AREDIFMETLK.D 2 4.257 0.264 K.EIPAWVPFDPAAQITK.Q 1 2.710 0.306 2 2.888 0.286 K.HVEDVPAFQALGSLNDLQFFR.Y 2 6.229 0.405 K.NILDRQDPPSVVVTSHQAPGEK.K 3 5.786 0.336 K.QKWEAEPVYVQR.A 2 3.317 0.357 K.WEAEPVYVQR.A 2 3.178 0.236 K.YYYDGKDYIEFNKEIPAWVPFDPAAQIT 3 4.611 0.342 K.Q R.AGEVQEPELR.G 1 2.240 0.189 2 2.565 0.091 R.QDPPSVVVTSHQAPGEK.K 2 2.767 0.255 3 3.720 0.278 R.QVEGMEDWKQDSQLQK.A 2 2.583 0.179 R.YSLTYIYTGLSK.H 1 2.629 0.299 2 3.803 0.354 P43403 homo sapiens (human). tyrosine-protein kinase zap-70 (ec IPI:IPI00179829.1 SW:ZA70_HUMAN 2.7.1.112) (70 kda zeta-associated E.EHLKLAGMADGLFL.L 1 2.527 0.111 G (99%) protein) (syk-related tyrosine kinase). 10/2001 P49750 homo sapiens (human). SW:ZAP3_HUMAN nuclear protein zap3 (zap113). L.QQLQQMHQKQMQ.C 2 2.677 0.128 A 10/2001 P16415 homo sapiens (human). zinc SW:ZF36_HUMAN finger protein zfp-36 (fragment). K.NTPRVNPCDSGECGEVVLGH.S 2 2.506 0.148 G 10/2001 Q02386 homo sapiens (human). zinc K.AFSQFSSLQVHQRVHTGEKPYQCAEC SW:ZN45_HUMAN 2 2.588 0.124 A finger protein 45 (brc1744). 10/2001 GK.G Q07157 homo sapiens (human). tight junction protein zo-1 (zonula IPI:IPI00216219.1 SW:ZO1_HUMAN occludens 1 protein) (zona occludens F.EQYSRSYEQ.V 1 2.021 0.081 G (91%) 1 protein) (tight junction protein 1). 10/2001 Q9uk55 homo sapiens (human). protein z-dependent protease inhibitor IPI:IPI00007199.1 SW:ZPI_HUMAN R.GTEAVAGILSEITAYSMPPVIK.V 2 3.021 0.422 O, P precursor (pz-dependent protease (95%) inhibitor) (pzi). 10/2001 R.IFSPFADLSELSATGR.N 2 4.212 0.427 SWN:DCD_HUMA P58461 homo sapiens (human). K.ENAGEDPGLAR.Q 2 2.682 0.335 A, G, P Supplementary Table 1 290 N dermcidin precursor (survival/evasion peptide) (preproteolysin) [contains: dcd-1]. 3/2002 K.GAVHDVKDVLDSVL.- 2 3.657 0.384 K.LGKDAVEDLESVGK.G 2 4.303 0.328 O43491 homo sapiens (human). band SWN:E4L2_HUMA 4.1-like protein 2 (generally expressed R.ETKEVQTNELKAE.K 2 2.578 0.172 P N protein 4.1) (4.1g). 3/2002 O60721 homo sapiens (human). sodium/potassium/calcium exchanger SWN:NKX1_HUMA 1 precursor (na(+)/k(+)/ca(2+)- R.RPVAKVMALEDLSKPGDGAIAVDE.L 2 2.527 0.100 G N exchange protein 1) (retinal rod na- ca+k exchanger). 3/2002 SWN:PRD7_HUMA Q9nqw5 homo sapiens (human). pr- IPI:IPI00180719.1 L.LQPENPCPGDQNQER.Q 2 2.925 0.082 O N domain zinc finger protein 7. 3/2002 (99%) O15020 homo sapiens (human). SWN:SPCP_HUM spectrin beta chain, brain 2 (spectrin, R.AELFAQSCCALESWLE.S 2 2.843 0.088 P AN non-erythroid beta chain 2) (beta-iii spectrin). 3/2002 Q9nrc6 homo sapiens (human). SWN:SPCR_HUM spectrin beta chain, brain 4 (spectrin, F.QALAEIADILR.Q 1 2.318 0.161 G, O AN non-erythroid beta chain 4) (beta-v spectrin) (bspecv). 3/2002 K.LQAMLQELLVSAQRLR.A 1 1.846 0.112 Q9nrl3 homo sapiens (human). SWN:ZIN_HUMAN G.GESLLVKQIEEQIKRNAAGK.D 2 3.338 0.232 A, O zinedin. 3/2002 G.SVLGQIPFLQNCEDEDSDEDDELDSVQ 3 3.591 0.137 HK.K
Supplementary Table 1 291 Supplementary Table 2. The 2438 human plasma proteins (identified with moderate confidence) and their interaction distributions.1 1. Proteins were identified with moderate confidence as described in the text. 2. ORF: open reading frames; CS: peptide charge states; “A”, “G”, “P”, “O” in the column “Group”: the proteins were found in the albumin-interaction group (A), the immunoglobulin-interaction group (G), the plasma free-protein group (P), and the original whole plasma, respectively; Some proteins were found in more than two groups and listed in one cell.
ORF Description Peptide CS Xcorr DelCn Group IPI Reference FAB FRAGMENT OF HUMANIZED 3D:1fveB F.YAMDYWGQGTLVTVSSASTK.G 2 2.405 0.216 G ANTIBODY 4D5, VERSION 7 Homo sapiens mRNA for leucine zipper IPI:IPI00182850.1 GP:AB001872_1 D.GEEGNTSDHSNSPDELADKL.E 2 2.427 0.228 P bearing kinase, complete cds. (97%) Homo sapiens mRNA for GP:AB002135_1 glycosylphosphatidylinositol anchor D.LVAVGKALEGMFRKLNHLLERL.H 2 2.403 0.164 P attachment 1 (GPAA1), complete cds. Human mRNA for KIAA0301 gene, GP:AB002299_1 T.EMLKTIKTVKADVDK.I 2 2.660 0.114 P partial cds. Human mRNA for KIAA0325 gene, GP:AB002323_1 A.MLLARIKLKGTVGEPTYDAEFQH.F 2 2.656 0.106 P partial cds. Human mRNA for KIAA0335 gene, IPI:IPI00162740.2 GP:AB002333_1 A.ATPFSCSSSILSGK.A 2 2.564 0.096 A complete cds. (98%) Human mRNA for KIAA0337 gene, GP:AB002335_1 K.SVTLGTQGSPITKMVSVGGR.L 1 1.833 0.171 P complete cds. Human mRNA for KIAA0340 gene, GP:AB002338_1 I.VNVLQATDLPARVDGRP.R 1 2.017 0.087 P partial cds. Human mRNA for KIAA0363 gene, GP:AB002361_1 I.FQVEAVEVTPL.S 2 2.447 0.115 P partial cds. Human mRNA for KIAA0382 gene, IPI:IPI00022164.1 GP:AB002380_1 F.SNLEDILQLHIGLNEQMKAV.R 2 2.442 0.138 A partial cds. (96%) Human mRNA for KIAA0383 gene, GP:AB002381_1 H.ERHISIKAISRA.T 1 2.188 0.089 G partial cds. Homo sapiens mRNA for neural IPI:IPI00004433.1 GP:AB003592_1 K.YLCTVQTTLESLSAVADIIV.R 2 2.687 0.160 G adhesion molecule NB-3, complete cds. (96%) Homo sapiens DNA for MICB, partial IPI:IPI00182652.1 GP:AB003609_1 H.YRAMQADCLQKLQR.Y 2 2.456 0.163 O cds, exon 4, 5. (99%) Homo sapiens mRNA for tomoregulin, IPI:IPI00170992.1 GP:AB004064_1 V.VVLCITR.K 1 1.953 0.150 O, P complete cds; TR. (97%) Homo sapiens mRNA for heparan-sulfate GP:AB006179_1 Y.ITLLRDPVSRYLSEW.R 2 2.406 0.118 G 6-sulfotransferase, complete cds. Homo sapiens mRNA for KIAA0292 GP:AB006630_1 Y.EGHNVGSNAQAYGTQSNYSYQP.Q 2 2.545 0.144 A gene, partial cds. Homo sapiens mRNA for AIE-75, GP:AB006955_1 F.ISHLIKGGQADSVGLQVG.D 1 2.089 0.105 G complete cds. Homo sapiens mRNA for KIAA0397 protein, partial cds; Start codon is not identified. hg00184 cDNA clone for GP:AB007857_1 KIAA0397 has a 43-bp insertion between C.SSSSSPHATPSHCSCIPD.R 2 3.087 0.140 P 1496-1497, and a 1978-bp insertion between 2019-2020 of the sequence of KIAA0397. Homo sapiens mRNA for KIAA0473 GP:AB007942_1 Q.SDDELLTLSSPHGNANGDKP.H 2 3.089 0.156 P protein, complete cds. Homo sapiens mRNA for RanBPM, W.NSPVGNQLDPIQREPVCSALNSAILETHN IPI:IPI00141126.1 GP:AB008515_1 3 3.860 0.228 P complete cds. LPKQPPL.A (96%) Homo sapiens mRNA for MDC3, IPI:IPI00021903.1 GP:AB009672_1 D.SIYKEQLNTRVVLVAVETWTEK.D 2 2.395 0.174 G complete cds. (92%) Homo sapiens mRNA for hSNF2H, IPI:IPI00020727.1 GP:AB010882_1 T.KFVFMLSTRAGGLGINLATADVVILY.D 2 2.557 0.144 O, P complete cds. (93%) Homo sapiens mRNA for BAI1- IPI:IPI00184654.1 GP:AB010894_1 associated protein 1, complete cds; R.KVVFAVPK.T 2 2.333 0.205 O (92%) BAP1. Homo sapiens mRNA for KIAA0608 GP:AB011180_1 N.LLNKPCQLAFFRVDHSMMLK.Y 2 2.250 0.176 A protein, partial cds. Homo sapiens gene for fructose-6- phosphate,2-kinase/fructose-2, 6- IPI:IPI00216306.1 GP:AB012229_1 I.ESVCDDPTVVASNIMVRQPGAPCFCGS.V 2 2.500 0.148 G bisphosphatase, partial cds; EC (91%) 2.7.1.105/EC 3.1.3.46. Homo sapiens mRNA for MS4A6, IPI:IPI00027556.1 GP:AB013104_1 S.LQWNSLSDADLHSAGIL.P 2 2.497 0.227 G complete cds. (91%) Rattus rattus mRNA for aquaporin, GP:AB013112_1 A.FAGGKLLVVG.E 1 2.224 0.081 A, G, P complete cds; human AQP9 like new Supplementary Table 2 1 aquaporin from rat liver. Homo sapiens hCAP-G mRNA for IPI:IPI00106495.1 GP:AB013299_1 chromosome-associated protein-G, L.GCCGLQNQDFARK.H 2 2.222 0.206 O (96%) complete cds. Homo sapiens mRNA for MOP-5, GP:AB013847_1 complete cds; similar to a mouse K.LTDNIFL.E 1 1.830 0.095 G unknown intracellular protein Mg11. Homo sapiens mRNA for KIAA0625 IPI:IPI00142538.1 GP:AB014525_1 V.DEAGQSCEIETLTP.L 2 2.757 0.143 A, G, O protein, partial cds. (98%) Homo sapiens mRNA for KIAA0644 GP:AB014544_1 S.EADLIEFPCDR.F 2 2.279 0.129 G protein, complete cds. Homo sapiens mRNA for KIAA0656 GP:AB014556_1 G.SFMAPSPSPVTPA.Q 1 2.193 0.147 G protein, complete cds. Homo sapiens mRNA for KIAA0658 IPI:IPI00216898.1 GP:AB014558_1 F.YYRLWDLYKKVKRNSTP.P 2 2.439 0.201 A protein, partial cds. (95%) Homo sapiens mRNA for KIAA0661 IPI:IPI00162563.1 GP:AB014561_1 R.HLISSLQNHNHQLKGD.A 2 2.585 0.100 O protein, complete cds. (91%) Homo sapiens mRNA for KIAA0666 IPI:IPI00000705.1 GP:AB014566_1 L.NEELRDIPQAAK.V 2 2.347 0.152 A protein, partial cds. (92%) Homo sapiens mRNA for KIAA0676 GP:AB014576_1 T.ESVLVNFFEKRVDIGLKI.K 2 2.532 0.202 O protein, partial cds. Homo sapiens mRNA for KIAA0698 protein, complete cds; HG00360 cDNA IPI:IPI00107855.1 GP:AB014598_1 clone for KIAA0698 has a 2509-bp L.QGMRKGAAMLF.P 1 2.333 0.165 P (96%) insertion at position 2933 of the sequence of KIAA0698.. Homo sapiens HRIHFB2091 mRNA, L.DFFYGYQVIPGSVCLKYNEKGMPTGEAMV GP:AB015336_1 3 3.843 0.235 O partial cds. AFESRDEATAAVID.L Homo sapiens HRIHFB2060 mRNA, GP:AB015348_1 I.NSLERKLKRR.L 2 2.486 0.124 O partial cds. Homo sapiens hTIM1 mRNA, complete cds, similar to Droshophila timeless gene GP:AB015597_1 F.YVMEYRELFLALFR.K 2 2.493 0.134 O sequence; similar to Droshophila timeless gene. Homo sapiens gene for telomerase GP:AB016767_1 A.STAPLAGVRLRAGLPAPAGAPR.P 2 2.205 0.137 G transcriptase, partial cds. Homo sapiens MASL1 mRNA, complete IPI:IPI00003495.1 GP:AB016816_1 E.LRSASPHAAYYGVSDKNLRRR.K 2 2.469 0.116 O cds. (92%) Homo sapiens mob1 mRNA, complete IPI:IPI00217607.1 GP:AB016839_1 L.QEEAHLNTSFK.H 1 2.006 0.114 O cds. (95%) Homo sapiens aik3 mRNA for GP:AB017332_1 Aurora/Ipl1-related kinase 3, complete L.FKSQIEKEGLEHQLRR.E 2 2.748 0.091 A cds. Homo sapiens mRNA for Death- IPI:IPI00003809.2 GP:AB018001_1 associated protein kinase 2, complete R.KLLVKETRKRLTIQEALRHPWITPVDN.Q 3 3.650 0.152 A (99%) cds. Homo sapiens mRNA for KIAA0717 GP:AB018260_1 R.DVFLTLEATPSHVVV.S 1 2.194 0.170 A protein, partial cds. Homo sapiens mRNA for KIAA0740 protein, partial cds; Start codon is not identified. hk03989 cDNA clone for IPI:IPI00001317.1 GP:AB018283_1 T.RLICARACNTTLTQYQLLA.T 2 2.406 0.122 G KIAA0740 has a 151-bp deletion at the (92%) region from 1835 to 1985 of the sequence of KIAA0740. Homo sapiens mRNA for KIAA0743 IPI:IPI00006300.2 GP:AB018286_1 E.GFTCDCSMTSYSGNQCNDPGATYI.F 2 2.422 0.113 A protein, complete cds. (97%) Homo sapiens mRNA for KIAA0748 GP:AB018291_1 T.PSHMFWNCNHPTDVPSIRILSR.E 2 2.229 0.112 G protein, complete cds. Homo sapiens mRNA for KIAA0754 IPI:IPI00019713.2 GP:AB018297_1 E.WIPVLQRPSRTAAVPTVK.D 2 2.405 0.109 A protein, partial cds. (94%) Homo sapiens mRNA for KIAA0800 protein, complete cds; hg03850 cDNA GP:AB018343_1 clone for KIAA0800 has a 857-bp G.NSPLIGRISF.I 1 2.250 0.095 O insertion at position 3404 of the sequence of KIAA0800.. Homo sapiens mRNA for KIAA0801 protein, complete cds; hg03949 cDNA clone for KIAA0801 has 923-bp and GP:AB018344_1 L.KKEIEEMKQGKKW.S 1 2.276 0.104 G 1880-bp insertions at positions 1486 and 1687 of the sequence of KIAA0801, respectively.. Homo sapiens mRNA for ABP125, complete cds; This sequence is a IPI:IPI00218005.1 GP:AB018358_1 D.DSRGKYLELLGYRKEDLGK.K 3 3.612 0.085 O product of alternative splicing of human (93%) ABP130. GP:AB019435_1 Homo sapiens mRNA for putative Q.EQSAQK.T 1 1.881 0.120 O IPI:IPI00184120.1
Supplementary Table 2 2 phospholipase, complete cds; putative. (93%) Homo sapiens DNA for immunoglobulin GP:AB019437_4 heavy-chain variable region, complete N.SYTTEYAASVK.G 2 2.430 0.133 A, G, O, P sequence, 1 of 5; 3-72. Homo sapiens DNA for immunoglobulin IPI:IPI00166866.1 GP:AB019440_1 heavy-chain variable region, complete C.EVQLVESGGGV.V 2 2.604 0.201 G, O (94%) sequence, 4 of 5; 3-20. Homo sapiens mRNA for KIAA0821 GP:AB020628_1 Y.AGDVSSSVKLMEQLLDILDAQLQA.L 2 2.449 0.142 A protein, complete cds. Homo sapiens mRNA for KIAA0829 IPI:IPI00168543.1 GP:AB020636_1 K.VKEYQVETIVDTLCTNMLSD.K 3 3.798 0.085 O protein, partial cds. (96%) Homo sapiens mRNA for KIAA0833 IPI:IPI00103715.1 GP:AB020640_1 R.MAEMTGSQQHKQASGGGSSGGGSGS.G 2 2.531 0.186 A protein, partial cds. (92%) Homo sapiens mRNA for KIAA0841 GP:AB020648_1 E.RRVLGSSERQVLILGLRRCCL.W 2 2.478 0.222 O protein, partial cds. Homo sapiens mRNA for KIAA0854 IPI:IPI00007256.1 GP:AB020661_1 Q.WPTPQEYDQLAAKTGLVRTEI.V 2 2.544 0.176 O protein, complete cds. (93%) Homo sapiens mRNA for KIAA0857 GP:AB020664_1 P.PRALLDLQGHLDAASRSSLCV.N 2 2.458 0.123 P protein, partial cds. Homo sapiens mRNA for KIAA0864 GP:AB020671_1 Q.DTLCLHQGPHPK.A 1 2.011 0.146 A, P protein, partial cds. Homo sapiens mRNA for KIAA0868 IPI:IPI00029343.2 GP:AB020675_1 I.NYNGVNITDL.A 1 2.116 0.092 P protein, partial cds. (97%) Homo sapiens mRNA for KIAA0892 IPI:IPI00002659.1 GP:AB020699_1 A.QAAAAQAAQ.A 1 2.018 0.142 O protein, partial cds. (94%) Homo sapiens mRNA for KIAA0895 K.WCHFSTLPKPKPQLSRSFEKGDDFSGKKF IPI:IPI00184441.1 GP:AB020702_1 3 3.587 0.141 G protein, partial cds. C.I (95%) Homo sapiens mRNA for KIAA0916 protein, partial cds; k06582 cDNA clone for KIAA0916 has a nucleotide IPI:IPI00178340.1 GP:AB020723_1 I.PKEELPHCPAGPK.G 2 2.433 0.117 O substitution at the position 1955 (C- T; (95%) nonsense mutation) of the sequence of KIAA0916.. Homo sapiens mRNA for squamous cell carcinoma antigen SART-3, complete IPI:IPI00006025.1 GP:AB020880_1 A.AVDVEPPSKQKEKAASL.K 2 2.479 0.143 A cds; squamous cell carcinoma antigen (92%) recognized by T cells. Homo sapiens mRNA for KARP-1- binding protein 1 (KAB1), complete cds; GP:AB022657_1 alternative splicing:see also Acc# A.GTSGCSIDAKQVEEQSA.A 1 2.005 0.105 O AB022658, AB022659; isolated by yeast two-hybrid screening. Homo sapiens FUT9 mRNA for alpha- GP:AB023021_1 C.KFYLSFENSIHK.D 1 1.921 0.082 G 1,3-fucosyltransferase IX, complete cds. Homo sapiens mRNA for KIAA0921 GP:AB023138_1 F.FYIGGSPNTADLPGS.P 2 2.459 0.101 P protein, partial cds. Homo sapiens mRNA for KIAA0929 GP:AB023146_1 Y.KADAPEGLAPEDRDKPAHQASETE.L 2 2.955 0.108 G protein, partial cds. Homo sapiens mRNA for KIAA0931 IPI:IPI00008185.2 GP:AB023148_1 V.QQSTNDTVF.M 1 2.125 0.206 A protein, partial cds. (96%) Homo sapiens mRNA for KIAA0940 IPI:IPI00047420.5 GP:AB023157_1 V.GVGVGVPSPLNPISPLKKPFSSN.V 2 2.452 0.155 G protein, complete cds. (93%) Homo sapiens mRNA for KIAA0950 IPI:IPI00017569.2 GP:AB023167_1 V.FSFQTKFDF.T 1 2.231 0.089 A protein, partial cds. (94%) Homo sapiens mRNA for KIAA0969 GP:AB023186_1 I.RVELSQATTALTNSTIEYEHL.E 2 2.562 0.119 P protein, complete cds. Homo sapiens mRNA for KIAA0973 GP:AB023190_1 S.IRIGPARRSSYKAKMAR.R 2 2.280 0.149 O protein, partial cds. Homo sapiens mRNA for KIAA0990 GP:AB023207_1 Q.ESGSLSFLSNSLKKLVPF.Q 2 2.889 0.092 O protein, complete cds. Homo sapiens mRNA for KIAA0996 IPI:IPI00034317.1 GP:AB023213_1 R.QKAVSTDRTSVPKIKKNVME.D 3 3.615 0.080 P protein, complete cds. (91%) Homo sapiens CES hBr3 mRNA for brain IPI:IPI00015895.1 GP:AB025028_1 Y.PFLPTVIDGVVLPKAPE.E 2 2.522 0.112 G carboxylesterase hBr3, complete cds. (98%) Homo sapiens mRNA for TCAM-1, partial R.VTGWFGCRHPCCPLLGMLSSEHESSSFS IPI:IPI00023634.1 GP:AB026156_1 3 3.677 0.165 G cds. GFPPPILE.L (98%) Homo sapiens IMPACT mRNA, complete IPI:IPI00020451.1 GP:AB026264_1 I.QKSQMTEPGPDVKKKTEE.E 2 2.632 0.103 O cds. (91%) Homo sapiens mRNA for dual specificity S.SSGSARSLNCGCSSASCCTVATYDKDNQ IPI:IPI00158733.1 GP:AB026436_1 3 3.854 0.118 O phosphatase MKP-5, complete cds. AQTQA.I (92%) Homo sapiens gene for endothelial IPI:IPI00009276.1 GP:AB026584_1 Y.QGAASLGGHLT.H 1 2.096 0.095 A protein C receptor, complete cds. (99%) Homo sapiens mRNA for chloride L.LVALSSELPFLGAGVQLQDNGYNGLLIAIN IPI:IPI00008538.1 GP:AB026833_1 2 2.466 0.114 A channel protein, complete cds. PQV.P (95%) Homo sapiens mRNA for RIE2 sid2705, GP:AB027196_1 A.SAGPAGESKPKSDGKNSSGSKRYNRK.R 2 2.530 0.141 O complete cds.
Supplementary Table 2 3 Homo sapiens Nori-3 mRNA for MAPKK IPI:IPI00102029.1 GP:AB027249_1 Y.LHQEKKLLHGDIKSSNV.V 2 2.688 0.159 O like protein kinase, complete cds; TOPK. (94%) Homo sapiens mRNA for basal transcriptional activator hABT1, complete GP:AB027258_1 E.QEESEEAACGSKK.R 2 2.406 0.208 A cds; basal transcriptional activator ABT1, human homolog. Homo sapiens mRNA for KIAA1026 GP:AB028949_1 A.TAAARAGGAAVIPVPEEPAL.P 2 2.476 0.142 O protein, partial cds. Homo sapiens mRNA for KIAA1059 IPI:IPI00010381.2 GP:AB028982_1 S.DPEMESSILISSDEGATYQK.Y 2 2.370 0.149 P protein, partial cds. (95%) Homo sapiens mRNA for KIAA1074 GP:AB028997_1 I.DDLTAELETAGSKCLHLDT.K 2 2.608 0.112 O protein, complete cds. Homo sapiens mRNA for KIAA1076 GP:AB028999_1 A.RAPTPLPPLLPAPLASCPPPMK.R 2 2.528 0.086 P protein, partial cds. Homo sapiens mRNA for KIAA1078 GP:AB029001_1 V.TETVCLTPNEDQLNQPTEPP.P 2 2.416 0.107 O, P protein, partial cds. Homo sapiens mRNA for KIAA1082 IPI:IPI00033465.1 GP:AB029005_1 A.TENKPLGFSFGCSSAQEAQK.D 2 2.328 0.151 O protein, partial cds. (92%) Homo sapiens mRNA for KIAA1093 GP:AB029016_1 L.GDFNDIMRKDRSGFR.P 2 2.532 0.092 O protein, partial cds. Homo sapiens mRNA for KIAA1112 protein, partial cds; hj05505 cDNA clone IPI:IPI00040381.1 GP:AB029035_1 for KIAA1112 has 983-bp and 352-bp R.RTAAPPPRLPGPYPADII.P 2 2.415 0.144 G (97%) insertions at the positions 820 and 1408 of the sequence of KIAA1112.. Homo sapiens mRNA for KIAA1115 protein, complete cds; hk02303 cDNA GP:AB029038_1 L.LEPRRPRSESVTVNSFFSSV.D 2 2.482 0.171 P clone for KIAA1115 has an 85-bp insertion.. Homo sapiens YEAF1 mRNA for YY1 GP:AB029551_1 and E4TF1 associated factor 1, complete P.AADEGFWDCSVCTFR.N 2 2.275 0.147 A cds. Homo sapiens MCC-B mRNA for 3- IPI:IPI00024580.3 GP:AB029826_1 methylcrotonyl-CoA carboxylase biotin- E.KVFVKAGDKVK.A 2 2.386 0.134 P (99%) containing subunit, complete cds. Homo sapiens mRNA for organic anion GP:AB031050_1 S.CFQQLRVIPKVTKHLLSNPVF.T 2 2.603 0.128 G transporter OATP-D, complete cds. Homo sapiens SEEK1 mRNA, complete IPI:IPI00182188.1 GP:AB031479_1 T.QEDILVPSSHPELFASVLPMAPEEAAR.L 2 2.655 0.274 P cds. (93%) Homo sapiens BPTF mRNA for IPI:IPI00177658.1 GP:AB032251_1 bromodomain PHD finger transcription C.NQVMKYILDKIDK.E 2 2.676 0.080 P (99%) factor, complete cds. GP:AB032369_1 Homo sapiens MIST mRNA, partial cds. S.QISLRDLSEVLEAE.K 2 3.505 0.163 G, O, P Homo sapiens VRL-2 mRNA for vanilloid IPI:IPI00168926.1 GP:AB032427_1 G.EDGSLSPSPADASR.P 2 2.202 0.121 P receptor like channel-2, complete cds. (97%) Homo sapiens mRNA for KIAA1120 GP:AB032946_1 protein, partial cds; Start codon is not D.IVVSLASAGGAKILGVLRV.L 2 2.757 0.112 P identified.. Homo sapiens mRNA for KIAA1122 IPI:IPI00220119.1 GP:AB032948_1 protein, partial cds; Start codon is not S.EDEESQGLPTM.A 2 3.038 0.116 G (94%) identified.. Homo sapiens mRNA for KIAA1136 IPI:IPI00167039.1 GP:AB032962_1 protein, partial cds; Start codon is not P.AQPNAGRSVALPASSALSANKIA.G 2 2.402 0.227 A (92%) identified.. Homo sapiens mRNA for KIAA1138 GP:AB032964_1 protein, partial cds; Start codon is not R.DVQAVLLSMF.S 1 1.819 0.148 P identified.. Homo sapiens mRNA for KIAA1171 protein, partial cds; Start codon is not identified.; hh05501 cDNA clone for IPI:IPI00008280.1 GP:AB032997_1 KIAA1171 has 960-bp and 414-bp P.AVVALLLHYSIDEAECFEKACR.I 2 2.370 0.114 P (93%) insertions (may be introns) after the positions 1275 and 1339 of the sequence of KIAA1171, respectively.. Homo sapiens mRNA for KIAA1175 IPI:IPI00008273.1 GP:AB033001_1 protein, partial cds; Start codon is not E.KIKSTWIK.N 2 2.289 0.148 O (92%) identified.. Homo sapiens mRNA for KIAA1178 GP:AB033004_1 protein, partial cds; Start codon is not V.YCRKLDPPGGQFYNSKRID.F 2 2.703 0.265 O identified.. Homo sapiens mRNA for KIAA1179 IPI:IPI00099050.1 GP:AB033005_1 protein, partial cds; Start codon is not Q.EERAGELQESQGDGLAAISL.Y 2 2.588 0.211 P (99%) identified.. Homo sapiens mRNA for KIAA1192 GP:AB033018_1 protein, partial cds; Start codon is not D.DEEDDPDALKDPLYQIDLQAY.L 2 2.505 0.109 A identified..
Supplementary Table 2 4 Homo sapiens mRNA for KIAA1212 IPI:IPI00181495.1 GP:AB033038_1 protein, partial cds; Start codon is not L.PISVDSPPAAADSNTTAASNVDKV.Q 2 2.439 0.118 P (92%) identified.. Homo sapiens mRNA for KIAA1213 GP:AB033039_1 protein, partial cds; Start codon is not G.GPLPSCFTPSPAPILNINSASFSQGL.E 2 2.446 0.137 P identified.. Homo sapiens mRNA for KIAA1219 IPI:IPI00166535.1 GP:AB033045_1 protein, partial cds; Start codon is not N.FPLSELMTEISTGVETTA.N 2 2.462 0.102 P (97%) identified.. Homo sapiens mRNA for KIAA1236 GP:AB033062_1 protein, partial cds; Start codon is not D.QREDSSAWPELLVPEKA.A 2 2.413 0.153 P identified.. Homo sapiens mRNA for KIAA1238 GP:AB033064_1 protein, partial cds; Start codon is not S.TERELLTKLPGGLFNMNQ.L 2 3.211 0.102 A identified.. Homo sapiens mRNA for KIAA1253 IPI:IPI00218931.1 GP:AB033079_1 protein, partial cds; Start codon is not L.LSIIGYNTTSTVP.K 2 2.479 0.183 O (95%) identified.. Homo sapiens mRNA for KIAA1256 IPI:IPI00184139.1 GP:AB033082_1 protein, partial cds; Start codon is not A.TSGTNLPPLMMPTPLVP.S 1 2.354 0.142 G (91%) identified.. Homo sapiens mRNA for KIAA1259 GP:AB033085_1 protein, partial cds; Start codon is not L.LQFQCRNRLLLTGTPIQNTMA.E 2 2.483 0.155 P identified.. Homo sapiens mRNA for KIAA1260 IPI:IPI00181174.1 GP:AB033086_1 protein, partial cds; Start codon is not T.LTLRRSPDDIPLMTPNTITM.I 2 3.133 0.102 O (96%) identified.. Homo sapiens mRNA for KIAA1262 IPI:IPI00180528.1 GP:AB033088_1 protein, partial cds; Start codon is not L.VSVVNSFHE.K 2 2.580 0.142 O (97%) identified.. Homo sapiens mRNA for KIAA1265 L.PEMLHGDGDNEEHGFCPVGQFILQNLGLL GP:AB033091_1 protein, partial cds; Start codon is not 3 3.778 0.123 G FGFAIMLVI.A identified.. Homo sapiens mRNA for KIAA1277 protein, partial cds; Start codon is not identified.; fh01940 cDNA clone for IPI:IPI00004868.2 GP:AB033103_1 Y.EFEDLLQSSSES.S 1 2.043 0.120 A KIAA1277 has a 1-bp insertion after the (92%) position 2103 of the sequence of KIAA1277.. Homo sapiens mRNA for KIAA1290 protein, partial cds; Start codon is not identified.; hj00086 cDNA clone for IPI:IPI00180241.1 GP:AB033116_1 KIAA1290 has 978-bp, 118-bp and 132- K.ERSSQDLEEKV.A 2 2.477 0.111 O (98%) bp insertions after the positions 1865, 2395 and 2594 of the sequence of KIAA1290, respectively.. Homo sapiens mRNA for postreplication GP:AB035274_1 repair protein hRAD18p, complete cds; Y.NAQCDALHPKSA.A 1 2.100 0.129 P RING-zinc-finger protein. Homo sapiens p53R2 mRNA for IPI:IPI00100213.1 GP:AB036063_1 Q.AENPFDFMENISLEGK.T 2 2.500 0.113 A ribonucleotide reductase, complete cds. (95%) Homo sapiens mRNA for seven transmembrane domain orphan receptor, IPI:IPI00103792.1 GP:AB037108_1 A.YLDDIASMPCHTGSINST.D 2 2.504 0.136 O complete cds; seven transmembrane (91%) domain containing protein. Homo sapiens C6ST-2 mRNA for GP:AB037187_1 chondroitin 6-sulfotransferase-2, V.PSVLDGGRDGDKGAEHCPGLQ.R 2 2.651 0.116 P complete cds. Homo sapiens mRNA for KIAA1303 IPI:IPI00166044.1 GP:AB037724_1 protein, partial cds; Start codon is not T.ELLPMIPDLPADLFTSCLTTPIK.I 2 2.263 0.113 O (97%) identified.. Homo sapiens mRNA for KIAA1307 IPI:IPI00180305.1 GP:AB037728_1 protein, partial cds; Start codon is not L.GTLTPMATEMLANGDGT.G 2 2.549 0.265 O (95%) identified.. Homo sapiens mRNA for KIAA1318 IPI:IPI00002353.1 GP:AB037739_1 protein, partial cds; Start codon is not G.ALSPLLMPALDSGTLSPLL.S 2 2.894 0.095 G (96%) identified.. Homo sapiens mRNA for KIAA1319 GP:AB037740_1 protein, partial cds; Start codon is not G.QGELTRKVEEL.Q 1 2.239 0.106 A identified.. Homo sapiens mRNA for KIAA1330 K.VRAAGDGEATTPEERESPTVSPRGPRKSL GP:AB037751_1 protein, partial cds; Start codon is not 3 3.528 0.145 P VPGSPGTPGR.E identified.. Homo sapiens mRNA for KIAA1331 IPI:IPI00218541.1 GP:AB037752_1 protein, partial cds; Start codon is not K.YADYISRDKPITFTQHQMPLFR.K 2 2.549 0.118 G (92%) identified..
Supplementary Table 2 5 Homo sapiens mRNA for KIAA1362 IPI:IPI00002231.1 GP:AB037783_1 protein, partial cds; Start codon is not V.IEDRILNQIL.Y 1 2.078 0.096 P (94%) identified.. Homo sapiens mRNA for KIAA1366 GP:AB037787_1 protein, partial cds; Start codon is not E.FLNYDMLIGVNQGEGLK.F 2 2.267 0.224 O identified.. Homo sapiens mRNA for KIAA1388 GP:AB037809_1 protein, partial cds; Start codon is not T.HSAERPFKCDLCPMGFKQQYALMRHR.R 2 2.414 0.206 A identified.. Homo sapiens mRNA for KIAA1394 GP:AB037815_1 protein, partial cds; Start codon is not H.DVDLVLFGGRL.L 2 2.468 0.103 O identified.. Homo sapiens mRNA for KIAA1400 IPI:IPI00010826.1 GP:AB037821_1 protein, partial cds; Start codon is not A.FDPDVGTNSLRDYEITPN.S 2 2.632 0.080 G (94%) identified.. Homo sapiens mRNA for KIAA1401 GP:AB037822_1 protein, partial cds; Start codon is not F.KPVELRT.K 1 2.264 0.101 P identified.. Homo sapiens mRNA for KIAA1405 protein, partial cds; Start codon is not identified. fg03134 cDNA clone for IPI:IPI00166597.1 GP:AB037826_1 KIAA1405 has 1259-bp and 1924-bp I.NLSLSALGNVISALVDGRCK.H 2 2.421 0.344 G (96%) insertions after the positions 1225 and 1518 of the sequence of KIAA1405, respectively.. Homo sapiens mRNA for KIAA1408 protein, partial cds; Start codon is not identified. fh04333 cDNA clone for GP:AB037829_1 E.EEEGSDNDDDEGEEEEEE.N 2 3.335 0.111 P KIAA1408 has a 184-bp deletion at the position between 3322 and 3507 of the sequence of KIAA1408.. Homo sapiens mRNA for KIAA1410 protein, partial cds; Start codon is not identified. fh06675 cDNA clone for IPI:IPI00002127.1 GP:AB037831_1 KIAA1410 has 184-bp and 1853-bp V.ASPATVSRCGMVYLEPSIL.G 2 2.637 0.104 O (97%) insertions after the positions 2107 and 2262 of the sequence of KIAA1410, respectively.. Homo sapiens mRNA for KIAA1414 protein, partial cds; Start codon is not identified. fh14368 cDNA clone for IPI:IPI00175418.1 GP:AB037835_1 KIAA1414 has a 1-bp insertion at the P.HAFKTVMGAAPELKVRLETAVRASQA.S 2 2.472 0.112 G (94%) position 1878 and a 152-bp deletion at the position between 4092 and 4245 of the sequence of KIAA1414.. Homo sapiens mRNA for KIAA1415 protein, partial cds; Start codon is not identified. hg04328 cDNA clone for IPI:IPI00185287.1 GP:AB037836_1 S.WKCLPAAEGDPQGQGLHDGSFG.P 2 3.460 0.205 G KIAA1415 has a 1103-bp insertion after (99%) the position 3417 of the sequence of KIAA1415.. Homo sapiens imup-1 mRNA for GP:AB038317_1 immortalization-upregulated protein 1, G.KAKKPKVKKK.E 1 2.030 0.087 O complete cds. Homo sapiens GC36 mRNA, complete IPI:IPI00016919.1 GP:AB038463_1 C.LQRGTLFEDADFPASNSSLFYSER.P 2 2.579 0.141 O cds; down-regulated in gastric cancer. (94%) Xenopus laevis XMT-SP1 mRNA for homolog of human MT-SP1, complete GP:AB038498_1 N.DCEDFSDEMSCTCTALQFR.C 2 2.267 0.106 A, P cds; CUB domain LDLR domain serine protease. Homo sapiens mRNA for KIAA1455 IPI:IPI00163721.1 GP:AB040888_1 protein, partial cds; Start codon is not L.SAITMPSVARHTMQTI.R 1 2.105 0.101 G (97%) identified.. Homo sapiens mRNA for KIAA1477 IPI:IPI00005280.2 GP:AB040910_1 protein, partial cds; Start codon is not L.TEMSVSSISSAGSSVASAVPSARP.R 2 2.557 0.211 O (92%) identified.. Homo sapiens mRNA for KIAA1482 GP:AB040915_1 protein, partial cds; Start codon is not L.VAGAADGCELVPRHLRG.R 1 2.002 0.134 P identified.. Homo sapiens mRNA for KIAA1494 GP:AB040927_1 protein, partial cds; Start codon is not A.HIQTSPQAKVLLH.M 2 2.497 0.120 O, P identified.. Homo sapiens mRNA for KIAA1495 A.ALMDGVVLCHLANHIRPRSVASIHVPSPAV IPI:IPI00186649.1 GP:AB040928_1 protein, partial cds; Start codon is not 3 3.561 0.161 A PKLSMAKCR.R (93%) identified.. Homo sapiens mRNA for KIAA1496 IPI:IPI00001697.1 GP:AB040929_1 G.EGFGYVVAFRPL.G 1 2.116 0.086 G, O protein, partial cds; Start codon is not (97%) Supplementary Table 2 6 identified.. Homo sapiens mRNA for KIAA1509 protein, partial cds; Start codon is not identified. fg00804 cDNA clone for GP:AB040942_1 P.HRGSLDRTDASTDLAMR.S 1 2.077 0.091 A KIAA1509 has a 1803-bp insertion after the position 2526 of the sequence of KIAA1509.. Homo sapiens mRNA for KIAA1510 protein, partial cds; Start codon is not identified. fg02934 cDNA clone for GP:AB040943_1 KIAA1510 has 286-bp, 143-bp and 96-bp P.DSLQVSWTPPLGRVLHYWL.T 2 2.422 0.113 G insertions after the positions 2358, 3078 and 3274 of the sequence of KIAA1510, respectively.. Homo sapiens mRNA for KIAA1514 protein, partial cds; Start codon is not identified. fh00815 cDNA clone for IPI:IPI00185370.1 GP:AB040947_1 E.AVPTAAPRNVVVHGATATQLDVTW.E 2 2.653 0.138 P KIAA1514 has a 245-bp insertion after (96%) the position 3087 of the sequence of KIAA1514.. Homo sapiens mRNA for KIAA1521 protein, partial cds; Start codon is not identified. fh14406 cDNA clone for IPI:IPI00164647.1 GP:AB040954_1 KIAA1521 has a 43-bp deletion at the V.VSGISATSEDIPN.K 2 2.501 0.170 A (93%) position between 975 and 1019 and a 81-bp insertions after the position 1139 of the sequence of KIAA1521, Homo sapiens mRNA for KIAA1525 protein, partial cds; Start codon is not identified. fj01939 cDNA clone for IPI:IPI00002061.1 GP:AB040958_1 Q.RPPSQHPSR.S 2 2.454 0.135 O KIAA1525 has a 73-bp deletion at the (94%) position between 1973 and 2047 of the sequence of KIAA1525.. Homo sapiens mRNA for KIAA1536 protein, partial cds; Start codon is not identified. fj00456 cDNA clone for GP:AB040969_1 R.LPPYGLCERGDPGSSPAGPREASPLVV.I 3 3.502 0.150 P KIAA1536 has a 232-bp insertion after the position 1632 of the sequence of KIAA1536.. Homo sapiens mRNA for KIAA1541 IPI:IPI00001816.1 GP:AB040974_1 protein, partial cds; Start codon is not K.IRWLPQQNAAHFLLSTNDKTIKLWKISE.R 3 3.607 0.145 A (94%) identified.. Homo sapiens Kox-1 mRNA for kidney I.AKYNRGKTVGVFCCGPNSLSKTLHKLSNQ IPI:IPI00176511.1 GP:AB041035_1 superoxide-producing NADPH oxidase, 3 3.780 0.107 O NN.S (95%) complete cds. Homo sapiens B3GALT1 gene for beta 1,3-galactosyltransferase polypeptide 1, GP:AB041407_1 complete cds; beta-3GalT1; similar to the P.FQNSGFNHWKMAYSLCR.Y 2 2.338 0.127 A product encoded by GenBank Accession Number E07739. Mus musculus brain cDNA, clone MNCb- 0448, similar to Homo sapiens cDNA GP:AB041557_1 R.PSSAKRRLSTLILHGGGTV.C 1 1.837 0.133 G FLJ20662, clone KAIA804; unnamed protein product. Mus musculus brain cDNA, clone MNCb- 5210, similar to Homo sapiens mRNA; GP:AB041607_1 L.VSQETLPRDSPDLLLLLRLL.A 2 2.556 0.138 G cDNA DKFZp586B0519; unnamed protein product. Homo sapiens strg mRNA for striatum- GP:AB042410_1 specific G protein-coupled receptor, L.LGLGLTVSLLSHCLV.A 2 2.665 0.087 G, P complete cds. Homo sapiens bk125H2.1 mRNA, IPI:IPI00183611.1 GP:AB042648_1 A.DLPAGRVRLWIDADKTITEV.D 2 2.477 0.233 A complete cds. (92%) Homo sapiens KChIP2b mRNA for IPI:IPI00045897.1 GP:AB044584_1 potassium channel-interacting protein 2b, A.LKQRFLKLLPCCGPQVLPSVSET.L 2 2.726 0.193 A (99%) complete cds. Homo sapiens hINADL mRNA for PDZ IPI:IPI00149092.1 GP:AB044807_1 domain protein 3' variant 4, complete P.SSSPSSIEDQSGTEPISS.E 2 3.288 0.127 A, O (97%) cds. Homo sapiens hFKBP65 mRNA for FK506 binding protein, complete cds, IPI:IPI00181212.1 GP:AB045981_1 T.SHDYGA.P 1 2.035 0.119 O, P cDNA:PSEC0056 from (98%) clone:NT2RP2000565. Homo sapiens mRNA for KIAA1549 GP:AB046769_1 protein, partial cds; Start codon is not V.TPRRGPVNIIFAVKSTQG.F 2 2.628 0.088 P identified..
Supplementary Table 2 7 Homo sapiens mRNA for KIAA1552 GP:AB046772_1 protein, partial cds; Start codon is not K.RSILGLGQAR.P 2 2.264 0.100 P identified.. Homo sapiens mRNA for KIAA1555 GP:AB046775_1 protein, partial cds; Start codon is not Y.NPNLPGV.S 1 2.013 0.098 A identified.. Homo sapiens mRNA for KIAA1569 IPI:IPI00178318.1 GP:AB046789_1 protein, partial cds; Start codon is not T.EKKDVLDFGDLTYGGW.K 2 2.598 0.151 O (99%) identified.. Homo sapiens mRNA for KIAA1570 IPI:IPI00163659.2 GP:AB046790_1 protein, partial cds; Start codon is not A.DTTDINHLETQPVSSKDSGI.G 2 2.455 0.226 A (96%) identified.. Homo sapiens mRNA for KIAA1573 IPI:IPI00030581.1 GP:AB046793_1 protein, partial cds; Start codon is not A.QVILSAIDEHD.K 2 2.734 0.090 O, P (93%) identified.. Homo sapiens mRNA for KIAA1576 GP:AB046796_1 protein, partial cds; Start codon is not V.EKVNPIKLYEENK.V 2 2.251 0.104 A identified.. Homo sapiens mRNA for KIAA1587 IPI:IPI00178756.1 GP:AB046807_1 protein, partial cds; Start codon is not P.VGRTMSLVSQNSRRRRRR.V 2 2.363 0.146 O (95%) identified.. Homo sapiens mRNA for KIAA1591 IPI:IPI00167243.1 GP:AB046811_1 protein, partial cds; Start codon is not L.EIVIMEVQGLKSVAPNR.I 2 2.341 0.100 A (99%) identified.. Homo sapiens mRNA for KIAA1597 IPI:IPI00030536.1 GP:AB046817_1 protein, partial cds; Start codon is not P.YVKAYLLPDKGKMGKKK.T 2 2.269 0.113 O (92%) identified.. Homo sapiens mRNA for KIAA1602 GP:AB046822_1 protein, partial cds; Start codon is not V.ALGTNSLKQQEPGLMGDPGARVY.S 2 2.432 0.198 O identified.. Homo sapiens mRNA for KIAA1603 IPI:IPI00152653.1 GP:AB046823_1 protein, partial cds; Start codon is not S.LARSVKSPITSKRIANI.I 2 2.510 0.147 O (98%) identified.. Homo sapiens mRNA for KIAA1620 GP:AB046840_1 protein, partial cds; Start codon is not S.KASRGQEGDAAPKSPVREKSPK.F 2 2.256 0.289 G identified.. Homo sapiens mRNA for KIAA1635 protein, partial cds; Start codon is not identified. fh23184 cDNA clone for GP:AB046855_1 KIAA1635 has a 4-bp deletion at the N.QSLTPGGSRLDPAGSFVPTNTK.Q 2 2.385 0.131 O position between 2446 and 2451, and 269-bp and 1-bp insertions after the positions 2355 and 4106 of the seq Homo sapiens mRNA for KIAA1636 protein, partial cds; Start codon is not identified. fh23458 cDNA clone for IPI:IPI00020785.1 GP:AB046856_1 KIAA1636 has a 17-bp different K.HVDANR.E 1 1.999 0.181 O (98%) sequence replacing a 22-bp sequence at the position between 735 and 758 of the sequence of KIAA1636, respectivel Homo sapiens mRNA for KIAA1638 protein, partial cds; Start codon is not identified. fj04819 cDNA clone for IPI:IPI00186151.1 GP:AB046858_1 P.NFVAVGLYHLAVGMNNR.A 2 2.321 0.122 A KIAA1638 has a 1746-bp insertion after (99%) the position 2563 of the sequence of KIAA1638.. Homo sapiens mRNA for KIAA1639 protein, partial cds; Start codon is not identified. fj06072 cDNA clone for GP:AB046859_1 KIAA1639 has a 55-bp deletion at the R.PSAAQCLSHPWFLKSMPAEE.A 2 2.762 0.092 O position between 2845 and 2901, and a 1-bp insertion after the position 1640 of the sequence of KIAA1639, Homo sapiens mRNA for KIAA1641 protein, partial cds; Start codon is not identified. fj10609 cDNA clone for IPI:IPI00186004.1 GP:AB046861_1 C.RLNAARCDHDQSHSSK.R 1 1.840 0.121 A KIAA1641 has a 1679-bp insertion after (99%) the position 896 of the sequence of KIAA1641.. Homo sapiens mRNA for KIAA1642 protein, partial cds; Start codon is not identified. hh02864 cDNA clone for GP:AB046862_1 Y.REVGELQAQTAALPLEPAS.K 2 2.433 0.123 P KIAA1642 has a 2-bp deletion at the position between 601 and 604 of the sequence of KIAA1642.. Homo sapiens hOBDPF mRNA for GP:AB048363_1 F.WGAKPLAGPDQK.E 2 2.290 0.103 P osteoblast differentiation promoting
Supplementary Table 2 8 factor, complete cds. Homo sapiens msps mRNA for mosaic GP:AB048797_1 serine protease, complete cds; non- A.SPAQASPAQASPARASPALAS.L 2 2.516 0.184 O transmembrane type. Homo sapiens mRNA for beta-1,3-N- IPI:IPI00031983.1 GP:AB049585_1 acetylglucosaminyltransferase bGnT-3, A.PSQRLSSFDPCFYR.D 2 2.230 0.108 P (96%) complete cds. Homo sapiens mRNA for membrane IPI:IPI00000775.1 GP:AB050468_1 K.NLKELHISSDSFL.C 1 1.828 0.128 A glycoprotein LIG-1, complete cds. (92%) Homo sapiens NIBAN mRNA, complete GP:AB050477_1 S.ESQVSEEQEEMGGQSSAAQATA.S 2 2.639 0.097 G cds. Homo sapiens mRNA for Graf2, IPI:IPI00163330.1 GP:AB050785_1 K.EALSHSFNTAIIPRPEGNAQLD.K 3 3.528 0.169 O complete cds. (91%) Homo sapiens mRNA for KIAA1650 GP:AB051437_1 protein, partial cds; Start codon is not Q.ERAALAVGSPGPGGGSFAREPSPTHR.G 2 2.280 0.121 G identified.. Homo sapiens mRNA for KIAA1683 IPI:IPI00174650.2 GP:AB051470_1 protein, partial cds; Start codon is not L.AQSPPDTRLAPSRSQPSVVSGTCHGL.N 2 2.408 0.150 O (98%) identified.. Homo sapiens mRNA for KIAA1684 GP:AB051471_1 protein, partial cds; Start codon is not K.QRAEYMRIQAQQQATKPSK.E 2 2.205 0.114 G identified.. Homo sapiens mRNA for KIAA1695 A.EPEAEAGAGQVADEAGQDIASAHEGAETE GP:AB051482_1 protein, partial cds; Start codon is not 3 3.815 0.175 O VEQAL.E identified.. Homo sapiens mRNA for KIAA1696 IPI:IPI00185498.1 GP:AB051483_1 protein, partial cds; Start codon is not S.QSCTANCNQGEETK.- 1 2.041 0.080 G (95%) identified.. Homo sapiens mRNA for KIAA1703 IPI:IPI00161472.1 GP:AB051490_1 protein, partial cds; Start codon is not Q.GATFVETDSPFTAAALAEEPLVK.E 2 2.394 0.117 G (94%) identified.. Homo sapiens mRNA for KIAA1707 IPI:IPI00218776.1 GP:AB051494_1 protein, partial cds; Start codon is not T.KKQEDDSTISTEFEKPSENY.H 2 2.644 0.088 A (96%) identified.. Homo sapiens mRNA for KIAA1717 GP:AB051504_1 protein, partial cds; Start codon is not F.DGSTLEGYYVDDALQGQGV.Y 2 2.414 0.149 P identified.. Homo sapiens mRNA for KIAA1725 IPI:IPI00028337.1 GP:AB051512_1 protein, partial cds; Start codon is not F.GSSQQYLLPRAGLELTS.S 2 2.587 0.164 G, O (94%) identified.. Homo sapiens mRNA for KIAA1738 GP:AB051525_1 protein, partial cds; Start codon is not H.PELPVKTLGFFIMCVYVYL.I 2 2.440 0.219 P identified.. Homo sapiens mRNA for KIAA1743 GP:AB051530_1 protein, partial cds; Start codon is not S.SSKGDSPELK.P 1 2.050 0.153 P identified.. Homo sapiens mRNA for KIAA1758 protein, partial cds; Start codon is not identified. fh20539 cDNA clone for IPI:IPI00103869.1 GP:AB051545_1 K.RSSSSSNTR.Q 1 1.982 0.083 O KIAA1758 has a 163-bp deletion at the (92%) position between 1899 and 2063 of the sequence of KIAA1758.. Homo sapiens mRNA for KIAA1772 protein, partial cds; Start codon is not identified. pj02583 cDNA clone for IPI:IPI00028189.1 GP:AB051559_1 Y.PGSPLPQPGLVVPVPTVRPLSR.T 2 2.290 0.166 P KIAA1772 has a 2148-bp insertion after (91%) the position 2255 of the sequence of KIAA1772.. Homo sapiens URAX1 mRNA, complete IPI:IPI00181445.1 GP:AB053121_1 A.EAGLPPVVDAIDDASVEED.L 2 2.509 0.105 P cds. (92%) Homo sapiens ALS2CR8 mRNA, IPI:IPI00171502.1 GP:AB053310_1 Y.VPYDGIPFVNAGTFLK.N 2 2.507 0.172 A complete cds, short form; short form. (94%) Homo sapiens ALS2CR11 mRNA, partial IPI:IPI00044667.1 GP:AB053313_1 F.EDLHDMTSFTHLKKVKSRSR.L 2 2.377 0.132 A cds,. (98%) Homo sapiens ALS2CR12 mRNA, GP:AB053314_1 K.AEKLAAQEKLEEMGKEYK.Y 2 2.388 0.148 A complete cds,. Homo sapiens ALS2CR15 mRNA, partial IPI:IPI00179047.1 GP:AB053317_1 Q.ARTEYRGALLWMK.D 2 2.390 0.127 G cds. (94%) Homo sapiens mRNA for BPOZ splice IPI:IPI00172612.1 GP:AB053326_1 Y.DDFLQRLLEQGIHSDVVFV.V 2 2.464 0.155 O variant type3, complete cds. (97%) Homo sapiens ABCA7/ABCA-SSN IPI:IPI00020941.1 GP:AB055390_1 A.PANLPALLLLLLLYG.W 2 2.561 0.168 G mRNA for ABCA-SSN, complete cds. (91%) Homo sapiens vest-1 mRNA, complete IPI:IPI00167766.1 GP:AB056652_1 cds; putative protein derived from A.VSNISPPSPDSKSLPRSVEHPKWN.W 2 2.814 0.082 A (96%) vestibule-1. GP:AB056663_1 Homo sapiens mRNA for ubiquitin K.WKQPLTVIVTPVSKLHFRV.W 2 2.574 0.185 O IPI:IPI00176010.1
Supplementary Table 2 9 protein ligase Itch, complete cds. (94%) Homo sapiens ASB-2 mRNA for ankyrin repeat-conteining protein with a SOCS box-2, complete cds; 5' ends established IPI:IPI00216028.1 GP:AB056723_1 N.HRCNRGWTALHESVSR.N 2 2.313 0.175 O by RACE from 3' end fragment (99%) (2574..2741) analyzed by differential display. Homo sapiens mRNA for KIAA1783 F.LASFQALGSEGQEDLSDREKCGAVLSQVL GP:AB058686_1 protein, partial cds; Start codon is not 3 3.954 0.085 P G.A identified.. Homo sapiens mRNA for KIAA1785 IPI:IPI00064238.1 GP:AB058688_1 protein, partial cds; Start codon is not G.KLRLLTKLLASK.S 1 1.927 0.081 A (97%) identified.. Homo sapiens mRNA for KIAA1787 IPI:IPI00178849.1 GP:AB058690_1 protein, partial cds; Start codon is not Q.CVQVSITNATGPMDNSLATSNTATEK.S 2 2.485 0.196 P (92%) identified.. Homo sapiens mRNA for KIAA1793 Q.LQLQTELRQLKVMKSTLVENQSEKELLCR GP:AB058696_1 protein, partial cds; Start codon is not 3 3.598 0.228 P LQK.L identified.. Homo sapiens mRNA for KIAA1801 GP:AB058704_1 protein, partial cds; Start codon is not W.MDSVSSHSPLSKSA.T 2 2.458 0.229 G identified.. Homo sapiens mRNA for KIAA1808 IPI:IPI00166534.1 GP:AB058711_1 protein, partial cds; Start codon is not C.MCQKCSLPVSVGSSAHLSQGLR.S 2 2.326 0.217 A (99%) identified.. Homo sapiens mRNA for KIAA1809 IPI:IPI00041148.2 GP:AB058712_1 protein, partial cds; Start codon is not P.LFSPPPRHHLDPHRIERLGAEEMAL.A 2 2.548 0.151 G (99%) identified.. Homo sapiens mRNA for KIAA1811 GP:AB058714_1 protein, partial cds; Start codon is not P.RSLQPPPGRPDPELSSSPRR.G 2 2.390 0.152 P identified.. Homo sapiens mRNA for KIAA1814 IPI:IPI00186502.1 GP:AB058717_1 protein, partial cds; Start codon is not Q.DNRALRGQSLQLLKARCEELQL.D 2 2.425 0.153 O (91%) identified.. Homo sapiens mRNA for KIAA1821 IPI:IPI00184300.1 GP:AB058724_1 protein, partial cds; Start codon is not I.TEKVSFLEKKVTELEND.S 2 2.759 0.097 O (92%) identified.. Homo sapiens mRNA for KIAA1823 GP:AB058726_1 protein, partial cds; Start codon is not G.VQDKAKYIENMSRGIY.K 2 2.527 0.201 P identified.. Homo sapiens mRNA for KIAA1839 protein, partial cds; Start codon is not identified. fj11961 cDNA clone for GP:AB058742_1 N.EKAAIKALTRLHQ.L 2 3.424 0.232 G KIAA1839 has a 226-bp insertion after the position 1456 of the sequence of KIAA1839.. Homo sapiens mRNA for KIAA1851 GP:AB058754_1 protein, partial cds; Start codon is not Q.DVPAELPAATADLDL.S 1 2.315 0.104 O identified.. Homo sapiens mRNA for KIAA1854 GP:AB058757_1 protein, partial cds; Start codon is not L.RNNHFSHLPVKGV.L 1 2.023 0.094 G identified.. Homo sapiens mRNA for KIAA1868 IPI:IPI00064128.1 GP:AB058771_1 protein, partial cds; Start codon is not E.CASAFTCKPRAPCTP.E 2 3.102 0.112 O (92%) identified.. Homo sapiens mRNA for KIAA1877 IPI:IPI00064125.1 GP:AB058780_1 protein, partial cds; Start codon is not L.VAWDPAPYSANLNLWYKKPDYN.L 2 2.407 0.159 G (96%) identified.. Homo sapiens mRNA for transcription IPI:IPI00186708.1 GP:AB059277_1 Q.KQMGNLEDAETKDLLVAA.E 2 2.646 0.139 P factor ELYS, complete cds. (97%) Homo sapiens mRNA for KIAA1887 GP:AB067474_1 protein, partial cds; Start codon is not A.PPFLASSLL.S 1 2.166 0.171 G identified.. Homo sapiens mRNA for KIAA1889 GP:AB067476_1 protein, partial cds; Start codon is not F.VHDFSTEDSATAAAASSCPQPGAD.C 2 2.668 0.107 P identified.. Homo sapiens mRNA for KIAA1890 IPI:IPI00177932.1 GP:AB067477_1 protein, partial cds; Start codon is not Q.APERIESSGNSLFLAFR.S 2 2.359 0.100 P (98%) identified.. Homo sapiens mRNA for KIAA1891 IPI:IPI00171533.1 GP:AB067478_1 protein, partial cds; Start codon is not C.SEYLRFLLDRLHEEEKILK.V 2 2.480 0.163 O (94%) identified.. Homo sapiens mRNA for KIAA1894 GP:AB067481_1 protein, partial cds; Start codon is not L.LSGVYKSQEAR.L 1 1.936 0.135 G identified.. GP:AB067487_1 Homo sapiens mRNA for KIAA1900 E.NALIAAI.A 1 2.078 0.133 A IPI:IPI00043705.3
Supplementary Table 2 10 protein, partial cds; Start codon is not (99%) identified.. Homo sapiens mRNA for KIAA1911 IPI:IPI00044728.1 GP:AB067498_1 protein, partial cds; Start codon is not D.GKLFATQYCGTGQFLVYNF.I 2 2.531 0.130 P (97%) identified.. Homo sapiens mRNA for KIAA1917 IPI:IPI00042382.1 GP:AB067504_1 protein, partial cds; Start codon is not A.SSSLAQSVMSMASSQ.I 2 2.648 0.193 P (99%) identified.. Homo sapiens mRNA for KIAA1919 Q.PGTMIVLSNIGSLTSSLFLVLFDKNPICLWI. GP:AB067506_1 protein, partial cds; Start codon is not 3 3.791 0.131 O, P A identified.. Homo sapiens mRNA for KIAA1929 protein, partial cds; Start codon is not identified. fj08985 cDNA clone for IPI:IPI00184984.1 GP:AB067516_1 KIAA1929 has 349-bp, 320-bp and 413- A.VTVPMIPLGLKETKE.L 1 2.292 0.110 A (95%) bp insertions after the positions 450, 936 and 1283 of the sequence of KIAA1929, respectively.. Homo sapiens mRNA for KIAA1931 GP:AB067518_1 protein, partial cds; Start codon is not S.EQQPDINLDLSPLTLGSP.Q 2 3.647 0.197 O identified.. Homo sapiens mRNA for KIAA1934 IPI:IPI00044696.1 GP:AB067521_1 protein, partial cds; Start codon is not L.KVFSGTASPSPGEETFEDW.L 2 2.718 0.128 O (93%) identified.. Homo sapiens mRNA for KIAA1936 L.QQQVRVAQKLLRDGELERAVQRLSGCQR IPI:IPI00168106.1 GP:AB067523_1 protein, partial cds; Start codon is not 2 2.547 0.130 A DA.E (99%) identified.. Human herpesvirus 1 gene for DNA GP:AB070847_1 polymerase, complete cds, clone:HSV-1 A.ACVTFKALFGNNAKITESLLK.R 2 2.211 0.208 P R98/0. Human PAC clone RP3-525N14 from Xq23, complete sequence; similar to zinc IPI:IPI00217082.1 GP:AC002086_1 V.AGQVVELSFIRAEIFAEILN.Y 2 2.561 0.105 O finger 5 protein from Gallus gallus, (95%) U51640 (PID:g1399185). Human cosmid clone LUCA12 from GP:AC002481_1 3p21.3, complete sequence; match to S.LPGTDPQDAERRRQLAL.K 2 2.469 0.168 A U09584 (PID:g1209020). Human DNA from chromosome 19- specific cosmid R27090, genomic sequence, complete sequence; Hypothetical 41.3 kDa human protein GP:AC002985_3 V.YRIISIGGAKAIINSTVTPNMT.F 2 2.647 0.096 P most similar to Vesl and GLGF proteins of rat; Residues 1-128 of hypothetical protein R27090_3 are 81% identical to Rat GLGF Homo sapiens chromosome 19, overlapping cosmids F18547, F11133, R27945, R28830 and R32804, complete IPI:IPI00176222.1 GP:AC003682_1 sequence; Hypothetical Kruppel-type F.RHRTSLIQHQKVHSGERPYNCT.A 2 2.443 0.198 P (97%) Zinc Finger Protein; Most similar to zinc finger protein ZNF132 (U09411)[Homo sapiens]. Homo sapiens PAC clone RP4-604G5 from 7q22-q31.1, complete sequence; Zn-alpha2-glycoprotein-like; similar to GP:AC004522_2 G.NDPPSVVVTSHQAPGEK.K 2 2.320 0.182 P S17564 (PID:g105274), but may be a pseudogene. See region from bp 52903 to bp 53208; H_DJ0604G05.2. Homo sapiens chromosome 19, cosmid R32184, complete sequence; Hypothetical human protein (partial CDS); CDS constructed from GP:AC004528_1 G.GQAGPRGLALLNGEYLLAAQLG.K 2 3.649 0.104 G combination of BLASTX, EST matches and Xgrail predictions. N-terminus of protein likely encoded in flanking cosmid R29942. Pr Homo sapiens chromosome 19, cosmid F24200, complete sequence; Novel GP:AC004611_1 107.5 kDa acidic protein; Highly similar E.RQRQREREIRETERR.R 2 2.248 0.102 P (71% identity) to (L43631) scaffold attachment factor [Homo sapiens]. Homo sapiens PAC clone RP5-1168D11 from 7p21-p22, complete sequence; IPI:IPI00175574.1 GP:AC004614_1 I.QTRAVWCAHVEGWT.T 1 2.274 0.230 A similar to f-spondin proteins AB006086 (93%) (PID:g2529225); H_DJ1168D11.1. Homo sapiens chromosome 19, fosmid GP:AC004755_1 K.ERALQPKKQRLVFTDLQR.R 2 2.386 0.140 A FOS37502 (LLfos-27A6) and 3'
Supplementary Table 2 11 overlapping PCR product, complete sequence; Hypthetical human transcription factor; Most similar to (X96553) hepatocyte nuclear factor 6 alpha [Rattus norvegicus] (67% identity), (U77975 Homo sapiens chromosome 19, fosmid FOS37502 (LLfos-27A6) and 3' overlapping PCR product, complete sequence; Hypothetical Ca-transporting D.DQLLYQAASPDEGALVTAARNFGYVFLSR IPI:IPI00166818.1 GP:AC004755_2 3 3.617 0.169 P ATPase-like human protein ONECUT3; .T (91%) Most similar to (AF038007) FIC1 [Homo sapiens] (54% identity), (U75321) chroma Homo sapiens PAC clone RP4-539M6 from 22, complete sequence; similar to IPI:IPI00175147.1 GP:AC004832_4 45 kDa secretory protein [Rattus S.LTCLQAGVYVLRFDNTY.S 1 2.007 0.149 O (97%) norvegicus]; similar to CAA10644.1 (PID:g4164418); H_DJ0539M06.4. Homo sapiens PAC clone RP4-771P4 from 7q11.21-q11.23, complete IPI:IPI00027007.1 GP:AC004883_2 sequence; similar to neutrophil cytosol A.QRQIKRGAPRRSSIRNAHSIHQR.S 2 2.259 0.176 A (95%) factor 1; similar to P14598 (PID:g127946); H_DJ0771P04.4. Homo sapiens PAC clone RP4-808A1 from 7q21.1-q31.1, complete sequence; IPI:IPI00144399.1 GP:AC004893_1 similar to hypothetical proteins P38811 M.WGDYLENIFVK.E 1 2.274 0.113 G (96%) (PID:g731689) and Q10064 (PID:g1351684); H_DJ0808A01.1. Homo sapiens PAC clone RP5-855D21, complete sequence; zinc finger protein IPI:IPI00175417.1 GP:AC004908_3 from gene of uncertain exon structure; T.HTGEKPYECHLCGKAF.N 1 2.102 0.081 P (99%) similar to Q99676 (PID:g3025333); H_DJ0855D21.3. Homo sapiens PAC clone RP5-894A10 from 7q32-q32, complete sequence; IPI:IPI00086369.2 GP:AC004918_2 similar to wee1-like protein kinase; I.FALGLTIAVAAGAESLP.T 2 2.651 0.091 O, P (99%) similar to P30291 (PID:g1351419); H_DJ0894A10.2. Homo sapiens PAC clone RP5-900K19 from 7q21.3-7q31.1, complete sequence; GP:AC004922_1 A.EVVESGSPAESLLLALLDEHQVE.A 2 2.816 0.196 O KIAA0632; match to PID:g3327078; H_DJ0900K19.1. Homo sapiens BAC clone CTB-54D4 from 7q31, complete sequence; similar to GP:AC005058_1 calcium-independent phospholipase A2; H.AFYDSQTWENILKDRMGSA.L 2 2.945 0.112 A similar to AC004392 (PID:g3367519); H_RG054D04.2. Homo sapiens BAC clone CTA-227L24 from 7q21.1-q21.2, complete sequence; IPI:IPI00028123.1 GP:AC005076_1 Q.LDEISPLGNEEVSAV.S 2 2.820 0.121 G match to AAC33480 (PID:g3493660); (96%) H_RG227L24.1. Homo sapiens BAC clone CTA-252K19 from 7p15.2-p21, complete sequence; IPI:IPI00061170.1 GP:AC005078_1 similar to ciliary dynein beta heavy chain; L.TETLDNYNELNAAMHLVLFEDAMQ.H 2 2.836 0.101 P (99%) similar to P23098 (PID:g118965); H_RG252K19.1. Homo sapiens BAC clone CTB-113D17 from 7p14-p15, complete sequence; IPI:IPI00220046.1 GP:AC005162_1 probable carboxypeptidase precursor; R.AFDMINRFIYGKGWDP.Y 1 1.816 0.081 A (99%) 64% similar to P42660 (PID:g1718107); H_RG113D17.1. Homo sapiens chromosome 19, cosmid R31665, complete sequence; Hypothetical ZNF-like human protein; GP:AC005498_2 Strongest similarity to (X12594) mkr5 V.KRELTGSLFSGIYAGKKL.F 2 2.555 0.220 G gene product [Mus musculus]; ZF28_MOUSE ZINC FINGER PROTEIN ZFP-28 (MKR5 PROTEIN). Homo sapiens chromosome 5, BAC IPI:IPI00001515.1 GP:AC005609_13 clone 203o13 (LBNL H155), complete E.RNEQPEANLDLSGNVSPTFEFWL.- 2 2.451 0.135 O (97%) sequence. Homo sapiens chromosome 19, cosmid R28784, complete sequence; Human GP:AC005954_1 homolog of (AF023617) ZO-3 [Canis R.EALKKKFMRVHDAE.S 1 2.017 0.081 G, P familiaris]; MAGUK protein family member; canine ZO-3 found at the tight
Supplementary Table 2 12 junction, interacts with ZO-1 and occludin; Human ortholog 84% identical to Homo sapiens PAC clone RP5-981O7 from 7q34-q36, complete sequence; IPI:IPI00168806.1 GP:AC006017_3 L.KKLGTSLKPDPVPKDYR.K 2 2.342 0.126 G similar to ALR; similar to AAC51735 (92%) (PID:g2358287); H_DJ0981O07.3. Homo sapiens BAC clone RP11-121A8 from 7p14-p13, complete sequence; T GP:AC006033_7 D.LPPNITLSW.Q 1 2.131 0.122 G cell receptor gamma chain; similar to PID:g339160. Homo sapiens PAC clone RP4-726N20 from 7q32-q34, complete sequence; N.GLSSSQEAQLQQADICDTLVVAVPSSLCP GP:AC006344_1 verified by mouse ESTs AA617614 2 2.215 0.151 A LR.L (NID:g2504819) and AA237696 (NID:g1861718); H_DJ0726N20.1. Homo sapiens BAC clone GS1-587J1 from 7p12-p14, complete sequence; GP:AC006365_1 R.SEAPESSESWKPEQLGEGSVPDG.P 2 2.507 0.090 O match to BAA20780 (PID:g2224584); H_GS587J01.1. Homo sapiens chromosome 19, BAC 37295 (CIT-B-21A4), complete GP:AC007228_3 S.RSSSLIKHQRI.H 2 2.514 0.139 P sequence; Hypothetical ZNF-like human protein. Homo sapiens chromosome 14 clone RP11-493G17 and CTD-2516D11 map 14q24.3, complete sequence; intron- GP:AC007954_6 T.MSEVSGA.T 1 2.364 0.095 O exon boundaries predicted by Genscan and supported by EST AA972465 and 725584. Homo sapiens chromosome 14 clones RP11-111O16 and RP11-61F4 containing genes for nuclear receptor coactivator NCoA-62 (nuclear receptor IPI:IPI00185266.1 GP:AC008372_2 L.FQSFDDTPLGTASLAQVHKAV.L 2 2.515 0.170 P coactivator NCoA-62) gene, complete (99%) cds; and unknown gene, complete sequence; ABC transporter-like; This new gene CgFancG/Xrcc9 genomic locus, GP:AC084885_1 complete sequence; CHO homolog of K.NDRLVEQARQLTGGSR.L 2 2.381 0.164 G human FANCG protein. Homo sapiens 16p13.3 sequence section 4 of 8; Peptide sequence identity with GP:AE006465_2 TR:Q9VQU2; PubMed reference N.ASARRWGRGGAAALPGPAASPRR.P 2 2.305 0.116 O 3279394; Structure of CDS predicted by GENSCAN. Homo sapiens 16p13.3 sequence section 5 of 8; Structure of CDS predicted by IPI:IPI00045456.1 GP:AE006466_2 V.ETELLKVLRPRGGQDCP.L 2 2.426 0.137 G GENSCAN; No supporting evidence (95%) except presence of CpG island. Homo sapiens 16p13.3 sequence section IPI:IPI00102177.1 GP:AE006639_7 R.PDSGDTLEGLPLPPGLK.Q 2 2.290 0.208 G 7 of 8; (99%) Homo sapiens TTF-I interacting peptide 21 mRNA, partial cds; TIP21; GP:AF000561_1 G.DSNPGLWPERDEDAPTGGL.F 2 2.410 0.128 O Transcription Termination Factor I Interacting Peptide 21. Human clone zeta unknown protein GP:AF001436_1 R.LHLETPQPSPQEGGSVDI.W 2 2.427 0.214 G mRNA, complete cds. Homo sapiens lymphoid phosphatase IPI:IPI00219138.1 GP:AF001846_1 K.ADKTYPTTVAENAKNIKKNR.Y 2 2.282 0.187 P LyP1 mRNA, complete cds. (97%) Homo sapiens neural cell adhesion IPI:IPI00160292.1 GP:AF002246_1 molecule (CALL) mRNA, complete cds; T.YEIGELNDI.N 1 2.394 0.102 P (97%) member of neural CAM superfamily. Human eucaryotic translation initiation GP:AF002815_1 factor 4G isoform 1 mRNA, partial cds; A.PRSQVDTLTSQPQALGCPEPV.G 2 2.564 0.206 G eIF4G isoform 1. Homo sapiens alpha-2,8- IPI:IPI00176575.1 GP:AF003092_1 sialyltransferase III mRNA, complete cds; Y.VSLKKENIFTTPKYASPGAPRMYMF.H 2 2.475 0.318 A (97%) ST8Sia III. Homo sapiens poly(ADP-ribose) IPI:IPI00021083.1 GP:AF005043_1 glycohydrolase (hPARG) mRNA, A.KMKSEYSSYPDINFNRLF.E 2 2.451 0.149 G (97%) complete cds. Homo sapiens muscle specific tyrosine IPI:IPI00023747.2 GP:AF006464_1 kinase receptor (MUSK) mRNA, S.SSSFSVSPTYSMTVIISIMSSFAIF.V 2 2.442 0.144 P (95%) complete cds. Homo sapiens kruppel-related zinc finger GP:AF007833_1 L.FTEGGGGAVMGAGGSGTA.T 2 2.599 0.109 A protein hcKrox mRNA, complete cds; Supplementary Table 2 13 zinc-finger transcription factor. Rattus norvegicus hereditary hemochromatosis protein homolog (RT1- GP:AF008587_1 CAFe) mRNA, partial cds; similar to V.LELQRGVLGQQVPTLVKVTR.H 2 2.426 0.111 O human hereditary hemochromatosis protein. Homo sapiens gamma-heregulin mRNA, IPI:IPI00024725.1 GP:AF009227_1 P.QKSYSSSETLKAYDQDARLAYGS.R 2 3.100 0.186 A complete cds. (94%) Homo sapiens Pig3 (PIG3) mRNA, GP:AF010309_1 complete cds; NADPH quinone L.YGLMGGGDINGPLFSK.L 1 2.196 0.088 A oxidoreductase homolog; p53 induced. Mus musculus neurotactin mRNA, complete cds; membrane-anchored chemokine; similar to human CX3C GP:AF010586_1 P.RKMAGEMVEGLR.Y 2 2.364 0.132 A chemokine precursor, encoded by GenBank Accession Number U84487 and U91835. Homo sapiens nuclear mitotic apparatus protein (NuMA) gene, partial cds; GP:AF012302_1 R.VEFATLQEALAHALTEKEGK.D 2 2.225 0.117 P structural nuclear protein; centrophilin stabilizes mitotic spindle in mitotic cells. Saimiri boliviensis RH30-like protein W.SSVAFNLFILALGVQWAILLDGFLSQFPPG GP:AF012427_1 mRNA, partial cds; similar to human RhD 2 2.509 0.158 A KLV.I and RhCE proteins. Homo sapiens EH-binding protein IPI:IPI00005030.1 GP:AF015043_1 mRNA, partial cds; binds EH domains of I.LYPSTVWD.F 1 2.006 0.108 O (96%) eps15. Homo sapiens clone ET16 ET putative N.VLGEDESSDDQDMEVNESAQNNLTKAVD IPI:IPI00013311.2 GP:AF015184_1 translation product (ET) mRNA, 3 3.647 0.163 P AFK.K (91%) alternatively spliced complete cds. Homo sapiens mucin (MUC 5AC) mRNA, IPI:IPI00103397.1 GP:AF015521_1 N.FNSIQADDFRTLSGVVEATAAAF.F 2 2.778 0.149 P partial cds; tracheal and gastric mucin. (93%) Homo sapiens thyroid hormone receptor coactivating protein mRNA, complete cds; p120; similar to Homo sapiens GP:AF016270_1 skeletal muscle abundant protein E.PEPVISGAEIVAGVVPATSME.P 2 3.286 0.128 P encoded by the sequence presented in the file with GenBank Accession Number X87613. Homo sapiens oxidoreductase mRNA, complete cds; NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase; IPI:IPI00178103.1 GP:AF016509_1 similar to retinol dehydrogenases; similar E.AFSDILRREIQHFGVKISI.V 2 2.425 0.160 P (94%) to sequences deposited in GenBank Accession Numbers U89281 and AF223225. Homo sapiens agrin precursor mRNA, IPI:IPI00177614.1 GP:AF016903_1 G.VPEDQAAVALERTFVGAGLR.G 2 2.210 0.125 A partial cds. (96%) Homo sapiens 73 kDA subunit of IPI:IPI00007818.1 GP:AF017269_1 cleavage and polyadenylation specificity W.QNHPELXDXPI.Y 1 2.104 0.107 G (99%) factor mRNA, partial cds. Homo sapiens cell cycle checkpoint protein RAD17 mRNA, complete cds; T.SLELLCQGCSGDIRSAINSLQFSSSKGENN IPI:IPI00155494.1 GP:AF017748_1 3 3.599 0.305 P similar to S. pombe rad17, Swiss-Prot LR.P (97%) Accession Number P50531. Homo sapiens clone 1400 unknown GP:AF020762_1 K.LKLFCPKNKIKDFIKL.K 2 2.418 0.196 G protein mRNA, partial cds. Homo sapiens ID:CLL008 IgM heavy GP:AF021950_1 Y.CARVWGGSGSYYIWFDPWGQG.T 2 2.557 0.162 O chain variable region mRNA, partial cds. Homo sapiens multidrug resistance protein (MRP), exon 31 and partial IPI:IPI00216267.1 GP:AF022853_3 A.EGGENLRVIVLDKGEIQEYGA.P 2 2.419 0.167 A alternatively spliced cds; alternatively (95%) spliced; missing exon 30. Homo sapiens lamin B receptor homolog TM7SF2 (TM7SF2) mRNA, complete IPI:IPI00019018.2 GP:AF023676_1 L.LYFTALLVHRE.A 1 2.036 0.132 A cds; transmembrane seven superfamily (93%) 2; ANG1. Homo sapiens soluble death receptor 3 beta (DR3) mRNA, complete cds; sDR3 beta; TNF receptor family member; GP:AF026071_1 G.PPPAWGHPDLHIPPL.L 1 2.110 0.089 A alternatively spliced product; lacks transmembrane domain due to insertion of 95 nucleotides from exon 3. Homo sapiens U5 snRNP 100 kD protein GP:AF026402_1 mRNA, complete cds; DEAD-box, RS G.ELADKKDRDA.S 2 2.689 0.097 O domain; PRP28p homolog; putative RNA
Supplementary Table 2 14 helicase. Homo sapiens alpha-3 type IX collagen L.LLLLLGQLLAAAGAQRVGLPGPPGPPGPP GP:AF026802_1 (COL9A3) gene, exons 27-32, and 3 3.891 0.149 P GKPG.Q complete cds. Homo sapiens immunoglobulin heavy GP:AF028097_1 chain (IGH) mRNA, CDR3 region, partial D.TAVYYCAKALDGSGSY.G 2 2.478 0.203 P cds; CDR3. Xenopus laevis odd-paired-like (opl) mRNA, complete cds; zinc finger GP:AF028805_1 V.ALGINPFADGMGAFKLNPSS.H 2 2.529 0.140 P transcription factor; similar to Mus musculus and Homo sapiens ZIC1. Homo sapiens Tax interaction protein 43 GP:AF028828_1 mRNA, partial cds; TIP-43; interacts with E.IHSPDAKHTVILRSK.D 2 2.340 0.118 G Tax of HTLV-1; has PDZ domain. Homo sapiens potassium channel IPI:IPI00100431.1 GP:AF029780_1 F.DRDPDAFKCVIEVYYFGEVH.M 2 2.457 0.172 P mRNA, complete cds. (93%) Homo sapiens SRp46 splicing factor IPI:IPI00051095.2 GP:AF031166_1 V.SRSRSRSRSSSMTRSPPRVSK.R 2 2.442 0.100 P (SRP46) mRNA, partial cds. (93%) Homo sapiens ataxin-2-like protein A2LP GP:AF034373_1 T.LEPQELARIAGK.V 2 2.281 0.100 O (A2LG) mRNA, complete cds. Homo sapiens molybdenum cofactor biosynthesis protein A and molybdenum IPI:IPI00219829.1 GP:AF034374_1 L.LPQLQKAGLSA.I 1 2.138 0.083 G cofactor biosynthesis protein C mRNA, (99%) complete cds. Homo sapiens clone B1F8B5H myosin- reactive immunoglobulin heavy chain GP:AF035018_1 G.FSLTTSGMDVGWIRQPPGKAL.E 2 2.523 0.101 A variable region mRNA, partial cds; autoantibody. Homo sapiens BAF57 (BAF57) gene, GP:AF035262_1 complete cds; HMG-domain containing Q.EGVDSMAEEGTSDSNTGSESNSA.T 2 2.468 0.223 O protein which is the 57 k. Homo sapiens phosphatidylserine- IPI:IPI00026319.1 GP:AF035269_1 specific phospholipase A1 deltaC (PS- K.LLVLGVSESSIHIIGVSLGAHVGGMV.G 2 2.517 0.087 O (99%) PLA1deltaC) mRNA, complete cds. Fugu rubripes MLL (MLL) gene, complete cds; similar to human leukemia GP:AF036382_1 E.SDKCEVSGR.E 1 1.948 0.121 P protein, MLL; similar to Drosophila trithorax. Homo sapiens CPRP1 mRNA, complete IPI:IPI00027542.1 GP:AF036536_1 D.YQMDFHPSPVVLKVYK.N 1 2.004 0.086 A cds. (96%) Homo sapiens RNA helicase (RIG-I) IPI:IPI00003782.1 GP:AF038963_1 F.CARQNCSHDWGIHVKYKTF.E 2 2.490 0.140 G mRNA, complete cds. (95%) Homo sapiens general transcription factor 2-I (GTF2I) mRNA, alternatively IPI:IPI00184662.1 GP:AF038967_1 T.EDSGISLEMAAVTVK.E 2 2.682 0.121 O spliced product, complete cds; (98%) alternatively spliced. Homo sapiens calcium-dependent chloride channel-1 (hCLCA1) mRNA, IPI:IPI00014625.1 GP:AF039400_1 V.ASDVPNAPIPDLFPPGQITDLKAE.I 2 2.541 0.233 G complete cds; transmembrane (96%) glycoprotein. Homo sapiens colon cancer antigen NY- GP:AF039442_1 CO-45 mRNA, partial cds; similar to A.VMEASTIMVYQIIFQINYRT.P 2 2.473 0.128 G Drosophilla maternal Tudor protein. Homo sapiens antigen NY-CO-33 (NY- IPI:IPI00152171.1 GP:AF039698_1 CO-33) mRNA, complete cds; zinc finger R.TGGTKFLKNLDTGHPVFFCNDCASQFR.T 2 2.220 0.121 A (96%) protein. Homo sapiens HCF-binding transcription factor Zhangfei (ZF) mRNA, complete cds; host cell factor- or C1-binding GP:AF039942_1 transcription factor; bZIP protein; similar L.ESRVRGLAAENQE.L 2 2.655 0.133 O, P to Luman; does not appear to bind to consensus bZIP binding sites by itself, which may be due Homo sapiens hyaluronidase (LUCA-3) mRNA, complete cds; one of a family of GP:AF040710_1 three hyaluronidase genes located at L.VQSIGVSAALGAAG.V 2 2.478 0.141 P 3p21.3 and related in sequence to PH- 20. Rattus norvegicus clathrin assembly protein short form (CALM) mRNA, GP:AF041373_1 S.KLPNDLLDLQQ.P 2 3.371 0.120 O complete cds; alternatively spliced; similar to short form of human CALM. Homo sapiens pRGR2 mRNA, partial cds; GADGH207; this gene fragment GP:AF041430_1 A.AAAASPAGADRTKPNRAGAAGA.A 2 2.652 0.104 O could release the glucose repression on the GAL1 promoter when expressed in
Supplementary Table 2 15 fusion with Gal4 activation domain in Saccharomyces cerevisiae. Homo sapiens SSC12 rearranged T cell GP:AF043173_1 receptor beta chain (TCRBV17) gene, L.GFLNTESFFRQ.G 1 2.065 0.109 A partial cds. Homo sapiens clone CPRF1-m1 IPI:IPI00179702.1 GP:AF043585_1 immunoglobulin lambda chain VJ region, R.VTISCTGSSSNTGAGY.D 1 2.058 0.099 G (94%) (IGL) mRNA, partial cds; VJ region. Homo sapiens guanine exchange factor IPI:IPI00182646.1 GP:AF043722_1 MCG7 isoform 1 mRNA, complete cds; I.SLFNSVSQ.W 1 2.394 0.177 A, O, P (97%) contains DAG and EF-hand domains. Synthetic construct from Homo sapiens clone I05 anti-Rh(D) antibody V kappa GP:AF044454_1 R.YLNWYQHK.P 1 1.828 0.095 G segment mRNA, partial cds; kappa light chain variable region. Synthetic construct from Homo sapiens clone M01 anti-Rh(D) antibody V lambda GP:AF044476_1 K.LLIYNNNQR.P 2 2.219 0.166 G segment mRNA, partial cds; lambda light chain variable region. Synthetic construct from Homo sapiens clone O02 anti-Rh(D) antibody V lambda GP:AF044482_1 G.NHNRPSGVPDR.F 2 2.209 0.156 O segment mRNA, partial cds; lambda light chain variable region. Homo sapiens hook2 protein (HOOK2) GP:AF044924_1 Q.RAGEERAPAHAQSFLAQQRL.A 2 2.590 0.110 O mRNA, complete cds. Mus musculus FLI-LRR associated protein-1 mRNA, complete cds; FLAP-1; IPI:IPI00013390.1 GP:AF045573_1 coiled-coil; binds to the leucine-rich K.EIDCLSPEAQR.L 2 2.221 0.103 O (98%) repeats of the human homolog of Drosophila flightless-I protein. Homo sapiens dimethylglycine dehydrogenase-like protein isoform 1 IPI:IPI00026667.1 GP:AF047004_1 G.PSRPLPSTANVVVIGGGSLGCQTL.Y 2 2.496 0.117 A mRNA, complete cds; putative sarcosine (99%) dehydrogenase. Homo sapiens clone asmrf1-t4 immunoglobulin lambda light chain VJ GP:AF047208_1 R.VTVSCSGSSSNIGSN.T 2 2.531 0.256 O region, (IGL) mRNA, partial cds; VJ region. Homo sapiens clone cpneg3-b1 immunoglobulin lambda light chain VJ GP:AF047240_1 K.SVNWYQQR.P 2 2.230 0.116 G region, (IGL) mRNA, partial cds; VJ region. Homo sapiens clone ds3-b2 immunoglobulin lambda light chain VJ IPI:IPI00017248.1 GP:AF047248_1 R.SYSASWYQQK.P 2 2.427 0.197 G region, (IGL) mRNA, partial cds; VJ (91%) region. Homo sapiens clone cpneg6-b1 immunoglobulin lambda light chain VJ GP:AF047262_1 E.DDQRPSGVPDR.F 2 2.443 0.153 P region, (IGL) mRNA, partial cds; VJ region. Homo sapiens clone FP7-t2 immunoglobulin lambda light chain VJ GP:AF047271_1 R.TLIYDTTDK.H 2 2.467 0.101 G region, (IGL) mRNA, partial cds; VJ region. Homo sapiens muskelin (MKLN1) E.NVRNSFWIYDIVRNSWSCVYKNDQAAKD IPI:IPI00166887.1 GP:AF047489_1 3 3.567 0.086 O mRNA, complete cds. NPTK.S (97%) Homo sapiens huntingtin-interacting GP:AF049523_1 protein HYPA/FBP11 (HYPA) mRNA, A.AAAAAAAAAAAANANASTSAS.N 1 2.259 0.087 G partial cds; similar to mouse FBP11. Homo sapiens clone BC9 immunoglobulin kappa light chain (IGVK- IPI:IPI00178190.1 GP:AF049688_1 M.QSIQLPYTFGQGTK.L 2 2.320 0.182 G A2) mRNA, IGVK-A2c allele, partial cds; (96%) VKII family, JK2. Homo sapiens growth arrest specific 11 IPI:IPI00016076.1 GP:AF050078_1 (GAS11) gene, exon 11 and complete T.LVSRKLEDVLESKNSTI.K 2 2.412 0.136 A (94%) cds. Homo sapiens immunoglobulin G Fd GP:AF051100_1 fragment mRNA, partial cds; IgG against V.NYAQNFQGR.A 2 2.329 0.181 G hepatitis B surface antigen. Homo sapiens SH3 domain containing adaptor protein (SCAP) mRNA, complete GP:AF051325_1 cds; putative Abl Tyr kinase D.EPIAFYAMGR.G 2 2.215 0.143 P phosphorylation site; proline-rich sequence. Homo sapiens neuronal double zinc GP:AF052224_1 finger protein (ZNF231) mRNA, complete E.AEDLVGK.P 1 2.075 0.151 O, P cds. Supplementary Table 2 16 Homo sapiens protocadherin 43 gene, exon 3, exon 4, and complete cds; IPI:IPI00031751.1 GP:AF052685_1 similar to protocadherin 43 encoded by E.AWRSGLVSTGRVVGVLLLL.G 1 2.404 0.128 O (99%) sequence in GenBank Accession Number L11373. Homo sapiens clone BSMRF-3 immunoglobulin lambda chain variable GP:AF052798_1 A.DYYCISYTISSTCVFGTGTKVTV.L 2 2.521 0.188 G region (DPL11) mRNA, partial cds; VJ region; VLII. Homo sapiens chromosome 7q22 GP:AF053356_3 K.MWGRVPFAPGPSPPPLLGNMDQER.L 2 2.261 0.138 G sequence, complete sequence; Homo sapiens electrogenic Na+ bicarbonate cotransporter form 2 (NBC) mRNA, complete cds; hKid-NBC; activity IPI:IPI00168680.1 GP:AF053754_1 V.IDALVGVGTPKLIVPSEFKPTS.P 2 2.471 0.173 A blocked by stilbene compounds,DIDS (96%) and SITS; activity not effected by absence of Cl-. Homo sapiens aortic carboxypeptidase- GP:AF053944_1 A.KTCNVDYDIGATQCNFILA.R 2 2.735 0.102 A like protein ACLP mRNA, complete cds. Homo sapiens clone 23777 putative transmembrane GTPase mRNA, partial IPI:IPI00006125.1 GP:AF054986_1 cds; similar to Homo sapiens putative E.VANKVSCAMTDEI.C 1 2.011 0.188 A (93%) transmembrane GTPase encoded by GenBank Accession Number U95822. Homo sapiens clone 23658 unknown mRNA, complete cds; similar to product IPI:IPI00171821.1 GP:AF054989_1 R.FVCEYAGEVLGFSEVQRR.I 2 2.242 0.119 G encoded by GenBank Accession Number (97%) U80776. Homo sapiens very large G-protein coupled receptor-1 (VLGR1) mRNA, IPI:IPI00165934.2 GP:AF055084_1 L.LDVQDAEIMAGKS.T 2 2.404 0.225 G complete cds; extracellular domain binds (97%) calcium. Mus musculus peroxisomal integral membrane protein (PMP47) mRNA, complete cds; similar to Candida boidinii GP:AF055463_1 A.KAIATTVTYPMQTVQSI.L 2 2.524 0.172 G PMP47 and Homo sapiens peroxisomal integral membrane protein encoded by GenBank Accession Number Y12860. Homo sapiens leucine-rich glioma- IPI:IPI00021091.1 GP:AF055636_1 inactivated protein precursor (LGI1) L.SALLLTEGKKPAKPKC.P 2 2.461 0.183 O (96%) mRNA, complete cds. Mus musculus putative deubiquitinating enzyme UBPY (Ubpy) mRNA, complete GP:AF057146_1 cds; interacts with Ras-GRF; high A.EASPIIQPAPATKSVPQVDRTKK.P 2 2.401 0.136 O expression in testis; similar to Homo sapiens hUBPY. Homo sapiens clone ASPBLL34 GP:AF058066_1 immunoglobulin lambda light chain VJ A.NTNRPSGVPDR.I 2 2.408 0.105 G region mRNA, partial cds. Homo sapiens yolk sac permease-like IPI:IPI00021379.2 GP:AF058319_1 molecule 2 (YSPL2) mRNA, complete S.PTFVGYTWKGLRKSDN.S 2 3.713 0.232 G, O (97%) cds. Homo sapiens clone G4-5-10 mucin 4 GP:AF058803_1 A.SASHGAIPVSTGM.A 1 2.249 0.098 O (MUC4) mRNA, partial cds. Homo sapiens Notch3 (NOTCH3) gene, IPI:IPI00029819.3 GP:AF058900_1 L.PLLLLLAGPGAAAPPCLDGSPCAN.G 2 2.774 0.098 G, O exon 33 and complete cds. (91%) Mus musculus polyhomeotic 2 protein (Mph2) mRNA, partial cds; polycomb IPI:IPI00165294.2 GP:AF060076_1 I.VHALTDLSSP.G 1 2.081 0.103 G group protein; similar to Homo sapiens (92%) polyhomeotic 2 protein. Homo sapiens clone ASSynL232 immunoglobulin lambda light chain GP:AF060144_1 S.YVLTQPPSLSVAPGQ.T 2 4.084 0.351 O, P variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone ASSynL44 immunoglobulin lambda light chain GP:AF060149_1 R.IYWYQQK.P 1 1.931 0.097 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens importin alpha 7 subunit IPI:IPI00155940.1 GP:AF060543_1 V.SSTTGESVIT.R 1 2.061 0.097 O mRNA, complete cds. (91%) Homo sapiens prostate derived STE20- GP:AF061943_1 like kinase PSK mRNA, complete cds; K.QQRILGEESGAPSPSPQKHGSLV.D 2 2.433 0.127 O protein kinase homolog. Homo sapiens clone 21u-33 GP:AF062118_1 immunoglobulin heavy chain variable K.GVQCEVRLVESGGGLIQPGGSLR.L 2 2.290 0.105 G region (IGH) mRNA, partial cds.
Supplementary Table 2 17 Homo sapiens clone 21u-34 GP:AF062119_1 immunoglobulin heavy chain variable N.QDGSDRDYVDSVK.G 2 2.437 0.101 P region (IGH) mRNA, partial cds. Homo sapiens genethonin 1 mRNA, IPI:IPI00022538.1 GP:AF062534_1 complete cds; contains leucine zipper G.DAEQEKDAPLGGA.A 2 2.538 0.105 O (94%) motif. Homo sapiens pituitary tumor GP:AF062649_1 transforming gene protein (PTTG) G.PLQSKQPTLCAKKITEK.S 2 2.371 0.149 G mRNA, complete cds. Homo sapiens brain my043 protein GP:AF063601_1 F.SKNGSATSKVLLLPPDVSALAT.Q 2 2.447 0.139 A mRNA, complete cds. - Homo sapiens brain my046 protein GP:AF063604_1 .MEKWYLMTVVVLIGLTVRWTVSLNSYSGAG 3 3.687 0.102 O mRNA, complete cds. KPPMFGDYEAQR.H Homo sapiens brain my051 protein GP:AF063609_1 V.PPRGPPWAGCHVPGCPPTATSLTTY.I 2 2.404 0.148 P mRNA, complete cds. Homo sapiens clone BCPBLL11 immunoglobulin lambda light chain GP:AF063695_1 K.PGQAPVLVISHDTDRPSGIPER.F 3 3.682 0.207 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone BCPBLL13 immunoglobulin lambda light chain GP:AF063696_1 Y.KSGSDKQEGSGVPSR.F 2 2.280 0.132 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone BCPBLL18 immunoglobulin lambda light chain GP:AF063700_1 K.PGSPPQYLLR.Y 2 2.267 0.297 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone BCSynL3 immunoglobulin lambda light chain GP:AF063721_1 R.PGSAPTTVIYEDTQR.Y 2 2.349 0.291 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone BCSynL47 immunoglobulin lambda light chain GP:AF063728_1 L.QFAYWYQKK.P 2 2.362 0.106 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone ITPBLL28 immunoglobulin lambda light chain GP:AF063745_1 T.NVHWYQQKPGQAPVLVVFAD.S 2 3.859 0.443 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone ITPBLL69 immunoglobulin lambda light chain GP:AF063751_1 K.SDSDKEQGSGVPSR.F 2 2.338 0.139 O variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone ITPBLL92 immunoglobulin lambda light chain GP:AF063759_1 V.SPGQTASFTCSGHKLGDK.Y 1 1.973 0.167 P variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens mutant guanine IPI:IPI00006762.2 GP:AF064092_1 nucleotide-binding protein G(s), alpha E.KAQREASSSYNQTNRL.Q 1 2.022 0.103 G (98%) subunit mRNA, complete cds. Homo sapiens clone LKPBLL72 immunoglobulin lambda light chain GP:AF064504_1 S.YQLTQPPSVSVSPGQTAR.I 2 2.429 0.316 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens clone LKPBLL85 immunoglobulin lambda light chain GP:AF064509_1 D.SISAYVFGTGTK.V 2 2.253 0.141 G variable region mRNA, partial cds; Vlambda-Jlambda. Homo sapiens LINE-1 like protein mRNA, partial cds; reverse transcriptase; GP:AF064597_1 similar to mouse related pol polyprotein I.KVDFRAKTMKDKDSH.F 1 2.172 0.152 O (reverse transcriptase): SwissProt Accession Number P11369. Homo sapiens transcription factor GP:AF064804_1 SUPT3H (SUPT3H) mRNA, complete L.AGSAAVPPR.V 1 1.901 0.127 A cds. Homo sapiens ion channel BCNG-2 IPI:IPI00218946.1 GP:AF064877_1 Y.FIQHGVVSVLTKGNKEMK.L 2 2.307 0.167 P mRNA, partial cds. (93%) Homo sapiens PITSLRE protein kinase beta SV1 isoform (CDC2L2) mRNA, complete cds; corresponding genomic IPI:IPI00178192.1 GP:AF067519_1 A.LLPIELKQELPKYLPALQGCR.S 2 2.339 0.160 P sequence deposited as GenBank (99%) Accession Numbers AF080689- AF080697 and AF092426-AF092428. Homo sapiens HDCGC13P mRNA, GP:AF067800_1 K.LLCASLLIFFLLLAISFF.I 2 2.402 0.182 P complete cds; similar to human Supplementary Table 2 18 macrophage lectin. Homo sapiens HDCGA21P mRNA, IPI:IPI00017515.1 GP:AF068290_1 V.VDRLIALDAAEEFFKLARRTY.P 2 2.627 0.098 P partial cds. (98%) Homo sapiens clone mcg58 GP:AF069046_1 immunoglobulin light chain variable W.VFGGGTTLTVLGQPK.A 2 2.201 0.270 G region (V lambda 4b) gene, partial cds. Homo sapiens embryonic ectoderm IPI:IPI00171248.1 GP:AF070418_1 development protein mRNA, partial cds; V.DADADENFYTCAWTYDSNTSHPL.L 2 2.432 0.347 O (95%) EED; polycomb group protein. Homo sapiens clone 24778 unknown P.PLHNSSSVACGGASGCQLELALPPWGHW IPI:IPI00009310.1 GP:AF070572_1 3 3.587 0.171 O mRNA. VYVR.V (93%) Homo sapiens tRNA IPI:IPI00164385.2 GP:AF074918_1 isopentenylpyrophosphate transferase Y.TVVDFRNRATALIEDIFAR.D 2 2.478 0.161 G (95%) precursor RNA, complete cds; IPTase. Homo sapiens neuronal cell death- IPI:IPI00102208.1 GP:AF077053_1 related protein mRNA, complete cds; V.PNKVATPMSVTSQ.R 1 2.483 0.223 A (99%) DN-7. Homo sapiens interleukin-18 receptor IPI:IPI00021998.1 GP:AF077346_1 accessory protein-like mRNA, complete K.QDLLLGSTGSISC.P 2 2.690 0.101 P (93%) cds; AcPL. Homo sapiens hypothetical SBBI03 GP:AF077599_1 L.EWVNSLQPARVTRWGGMISTPDAV.L 2 2.421 0.247 G protein mRNA, complete cds; SBBI03. Homo sapiens protein inhibitor of K.YLNGLGRLPAKTLKPEVRLVKLPFFNMLDE IPI:IPI00166500.1 GP:AF077952_1 activated STAT protein PIASy mRNA, 3 3.715 0.285 G .L (91%) complete cds. Homo sapiens PTD002 mRNA, complete IPI:IPI00103658.1 GP:AF078857_1 K.KAVSLINAIDTGRFPR.L 2 2.259 0.143 O cds. (95%) Dictyostelium discoideum cytochrome c oxidase assembly protein (coxA) gene, complete cds; similar to Homo sapiens GP:AF079448_1 V.SSRLSKNNNINQSFNNGFLQ.S 2 2.722 0.175 P cytochrome c oxidase assembly protein COX15 encoded by sequence in GenBank Accession Number AF044323. Rattus norvegicus splicing factor 1 GP:AF079873_1 homolog mRNA, partial cds; similar to K.VMIPQDEYPEINFVGLLIGPRGNTLKNI.E 3 3.531 0.139 P human splicing factor 1. Mus musculus semaphorin IV isoform a mRNA, complete cds; sema IV(a); GP:AF080091_1 P.QATVKWLFQRDPSDRRREIRA.E 2 2.731 0.086 G alternatively spliced; similar to Homo sapiens sema IV. Homo sapiens testis-specific chromodomain Y-like protein (CDYL) mRNA, alternatively processed, complete GP:AF081258_1 cds; alternatively processed; alternative I.HPLVPQVPGPVTAAMATGLAVNGK.G 2 2.436 0.109 P polyadenylation site results in a shorter 3' UTR than in the sequence present in GenBank Accession Numbe Homo sapiens 38kDa splicing factor IPI:IPI00006723.1 GP:AF083383_1 A.AVQTFQNTYQVLAVTFNDTSDQI.I 2 2.500 0.195 G mRNA, complete cds; SPF 38. (93%) Homo sapiens 45kDa splicing factor GP:AF083384_1 S.VEKTSKRGGKIIVGDATEK.G 2 2.611 0.081 P mRNA, complete cds; SPF 45. Homo sapiens putative WHSC1 protein (WHSC1) mRNA, alternative splice IPI:IPI00107486.1 GP:AF083391_1 product ending in intron 11, complete D.SGNVNGKKRNHTK.R 2 2.254 0.169 G (92%) cds; alternatively spliced; ends in intron 11. Homo sapiens Ras-like GTP-binding GP:AF084465_1 protein REM mRNA, complete cds; lacks A.CAVVFDCKFIETSATLQHNVA.E 2 2.744 0.127 A C-terminal CAAX motif. Homo sapiens LARP mRNA, complete GP:AF085235_1 L.SRQSATEIPLPMPPLADTEKLI.R 2 2.410 0.109 G cds; similar to mouse DIFF6. Homo sapiens HSPC031 mRNA, GP:AF085360_1 Y.KVWIKPGAEQSFLYGNHVLKS.G 2 2.415 0.277 A complete cds. Homo sapiens clone 55 T-cell receptor GP:AF088345_1 beta chain (TCRBV10S1P) mRNA, K.WDSYFGAGTRLSVL.E 1 1.841 0.150 O partial cds. Homo sapiens clone TCRBV19S1P.43 T- GP:AF088524_1 cell receptor beta chain (TCRBV19S1P) L.GVDNEQFFGPGTRLTVLE.D 1 2.053 0.148 O mRNA, partial cds. Homo sapiens clone TCRBV19S1P.51 T- GP:AF088532_1 cell receptor beta chain (TCRBV19S1P) R.ASSQXRETQYXGPGTRLLVL.E 2 2.476 0.229 A mRNA, partial cds. Homo sapiens clone TCRBV19S1P.89 T- N.PVLRTGRHGTVSRASTPGQRVGTLGSPL GP:AF088570_1 cell receptor beta chain (TCRBV19S1P) 3 3.720 0.215 O HFGNGTR.L mRNA, partial cds. GP:AF088592_1 Homo sapiens clone TCRBV19S1P.111 G.TVSRASSPPFGSGTRLTV.V 2 2.442 0.157 P
Supplementary Table 2 19 T-cell receptor beta chain (TCRBV19S1P) mRNA, partial cds. Homo sapiens clone TCRBV19S1P.168 GP:AF088649_1 T-cell receptor beta chain G.DTALYLAPAVLPPQGPSL.N 2 2.613 0.189 G (TCRBV19S1P) mRNA, partial cds. Homo sapiens fibrousheathin II mRNA, complete cds; possible human sperm IPI:IPI00220406.1 GP:AF088868_1 A.LLSDTSLKGQP.E 2 2.528 0.103 P fibrous sheath protein; undergoes (94%) phosphorylation during capacitation. Homo sapiens clone 614 unknown GP:AF091080_1 L.KDLNQRQAHVDFEAMLR.Q 2 2.413 0.163 G mRNA, complete sequence. Homo sapiens alpha-catenin-like protein IPI:IPI00001712.1 GP:AF091606_1 D.VASLKASKDTVCEEIQN.A 2 3.285 0.122 G VR22 mRNA, complete cds. (92%) Homo sapiens PHD finger protein 3 GP:AF091622_1 L.KVPEEKAAKVATKIE.K 1 2.010 0.080 A (PHF3) mRNA, complete cds. Homo sapiens immunoglobulin lambda light chain variable region mRNA, partial GP:AF092503_1 V.SKRPSGVPDR.F 2 2.428 0.102 G cds; specific for Parvovirus B19 NS1 protein. Homo sapiens germ cell specific Y-box GP:AF096834_1 V.SGTPAPPARSQADK.P 1 1.950 0.097 O binding protein mRNA, complete cds. Homo sapiens type 1 diabetes autoantigen ICA12 mRNA, complete cds; GP:AF098915_1 similar to Mus musculus SOX13 encoded W.DCSSPEGNGSPEPKRPGASEAAS.G 2 2.632 0.209 G by GenBank Accession Number AB006329. Caenorhabditis elegans cosmid Y71H10B, complete sequence; similar to human 5'-nucleotidase (SW:P49902); GP:AF099002_2 S.CDAFQKMMKCRGKEVL.Y 1 2.093 0.090 G coded for by the following C. elegans cDNAs: yk851h10.5, yk762e05.5, yk851h10.3, yk762e05.3. Homo sapiens glucocorticoid modulatory IPI:IPI00008601.3 GP:AF099013_1 element binding protein-1 (GMEB1) R.NQVEQGEEQFLYTLTD.L 1 1.847 0.089 P (94%) mRNA, complete cds. Homo sapiens PTD016 protein mRNA, GP:AF100745_1 C.VHSRLRGHSHSEARLTDDT.A 2 3.086 0.198 P complete cds. Caenorhabditis elegans cosmid F56E10, GP:AF101312_1 complete sequence; contains similarity to L.IVRKELNL.L 1 2.221 0.092 A human diaphanous 1 (GB:AF051782). Homo sapiens tumor antigen SLP-8p (HCC8) mRNA, complete cds; HOM- IPI:IPI00183687.1 GP:AF102177_1 E.QVPKIFMKPDFALDDSLTFNSVL.P 2 2.558 0.106 G HCC-8; hepatocellular carcinoma (99%) associated antigen. Homo sapiens isolate donor D clone GP:AF103032_1 D105 immunoglobulin heavy chain K.NTLSLQMNSLR.A 2 2.260 0.185 G variable region mRNA, partial cds. Homo sapiens isolate donor D clone GP:AF103041_1 D118 immunoglobulin heavy chain I.SIDMSKTQFSLNLTSVTAADT.A 2 2.712 0.090 O variable region mRNA, partial cds. Homo sapiens isolate donor D clone GP:AF103046_1 D124 immunoglobulin heavy chain R.QAPGQGLEWVGR.I 2 2.442 0.235 P variable region mRNA, partial cds. Homo sapiens isolate donor D clone D14 GP:AF103049_1 immunoglobulin heavy chain variable N.DDSIYYGDSVK.G 2 2.254 0.175 G region mRNA, partial cds. Homo sapiens isolate donor D clone D34 GP:AF103064_1 immunoglobulin heavy chain variable Y.ADYWGQGTLVTVSSASTK.A 2 2.325 0.356 G region mRNA, partial cds. Homo sapiens clone N112 GP:AF103112_1 immunoglobulin heavy chain variable L.EWVSSISSSSTYIDYADSLKGRFS.I 2 2.419 0.208 P region mRNA, partial cds. Homo sapiens clone N128 GP:AF103125_1 immunoglobulin heavy chain variable A.AADWGQGTLVTVSSASTK.G 2 2.273 0.115 G region mRNA, partial cds. Homo sapiens clone N154 IPI:IPI00220120.1 GP:AF103148_1 immunoglobulin heavy chain variable M.GAFDIWGQGTMVTVSSASTK.G 2 2.367 0.181 G (93%) region mRNA, partial cds. Homo sapiens clone N188 GP:AF103175_1 immunoglobulin heavy chain variable R.ETYHWGQGTLVTVSSASTK.G 2 2.319 0.150 G region mRNA, partial cds. Homo sapiens clone N189 GP:AF103176_1 immunoglobulin heavy chain variable L.QLNSVTAADTAVYFCARVHR.L 2 2.637 0.275 G region mRNA, partial cds. Homo sapiens clone N19 GP:AF103177_1 W.VRQMPGKGLEWMGIVNPFDSDTR.Y 2 2.288 0.116 P immunoglobulin heavy chain variable
Supplementary Table 2 20 region mRNA, partial cds. Homo sapiens clone N41 GP:AF103243_1 immunoglobulin heavy chain variable S.GPGVVKPSETLSLMCTVSGYSITSH.Y 2 3.364 0.108 G region mRNA, partial cds. Homo sapiens clone N49 R.AEDTAVYYCARVLGVGSIFGVVTPGYYYL GP:AF103251_1 immunoglobulin heavy chain variable 3 3.628 0.183 G DVW.G region mRNA, partial cds. Homo sapiens clone N78 GP:AF103278_1 immunoglobulin heavy chain variable D.HIGSTNYNPSLK.S 2 2.278 0.337 G region mRNA, partial cds. Homo sapiens clone Z25 immunoglobulin GP:AF103327_1 heavy chain variable region mRNA, Q.GTTVTVTSASTK.G 2 2.378 0.344 G partial cds. Homo sapiens clone Z57 immunoglobulin IPI:IPI00220120.1 GP:AF103352_1 heavy chain variable region mRNA, S.FDDWGQGTLVTVSSASTK.A 2 2.478 0.209 G (91%) partial cds. Homo sapiens isolate donor D clone IPI:IPI00007888.1 GP:AF103379_1 D116K immunoglobulin kappa light chain R.LLIYGTSNR.A 2 2.396 0.184 O (91%) variable region mRNA, partial cds. Homo sapiens isolate donor Z clone IPI:IPI00003457.1 GP:AF103540_1 Z107K immunoglobulin kappa light chain R.ASQSINSWLAWYQQK.P 2 2.310 0.145 G (91%) variable region mRNA, partial cds. Homo sapiens isolate donor Z clone IPI:IPI00007884.1 GP:AF103541_1 Z109K immunoglobulin kappa light chain R.ASQSVSSKLAWYQQK.A 2 2.259 0.188 G (92%) variable region mRNA, partial cds. Homo sapiens isolate donor Z clone IPI:IPI00030206.1 GP:AF103546_1 Z116K immunoglobulin kappa light chain R.ASQSISSSYLAWYQQK.P 2 2.224 0.147 G (97%) variable region mRNA, partial cds. Homo sapiens isolate donor D clone IPI:IPI00152189.1 GP:AF103593_1 D10L immunoglobulin lambda light chain A.DHASGSNFVVVF.G 1 2.384 0.104 A (98%) variable region mRNA, partial cds. Homo sapiens isolate donor D clone GP:AF103600_1 D38L immunoglobulin lambda light chain T.WYQQTPGQAPR.T 2 2.337 0.253 G variable region mRNA, partial cds. Homo sapiens isolate donor N clone IPI:IPI00154742.1 GP:AF103626_1 N141L immunoglobulin lambda light K.LLIYGNTNRPSGVPDR.F 2 2.405 0.102 G (94%) chain variable region mRNA, partial cds. Homo sapiens isolate donor N clone GP:AF103627_1 N144L immunoglobulin lambda light D.SSLSSVFGGGTK.L 2 2.333 0.177 G chain variable region mRNA, partial cds. Homo sapiens isolate donor N clone GP:AF103659_1 N223L immunoglobulin lambda light V.TISCSGSSSNIGINAVNWYQQ.F 2 2.750 0.240 O chain variable region mRNA, partial cds. Homo sapiens isolate donor N clone GP:AF103676_1 N49L immunoglobulin lambda light chain G.TQVTVLGQPK.A 2 2.235 0.108 P variable region mRNA, partial cds. Homo sapiens isolate donor N clone N5L GP:AF103679_1 immunoglobulin lambda light chain R.FSGSNSGDAATLTISR.V 2 2.325 0.167 G variable region mRNA, partial cds. Homo sapiens isolate donor Z clone GP:AF103701_1 Z119L immunoglobulin lambda light D.YYCSSFAGNNNLIFGGGTKLTVLG.Q 2 3.498 0.123 O chain variable region mRNA, partial cds. Homo sapiens isolate donor Z clone GP:AF103717_1 Z62L immunoglobulin lambda light chain R.FSGSIDSSSDSASLTISGLK.T 2 2.395 0.308 G variable region mRNA, partial cds. Homo sapiens clone C40 unknown mRNA; expression decreases in HER- GP:AF103798_1 L.FRLLKTLDTGETPSETKM.S 2 2.753 0.101 P 2/neu overexpressing cells; differentially expressed. Mus musculus testis-enriched protein tyrosine phosphatase mRNA, complete cds; TEP; similar to Homo sapiens megakaryocyte PTPase MEG-01; non- IPI:IPI00019949.1 GP:AF106702_1 V.GHLVDHVVHMSPSEDFVSQR.S 2 2.582 0.163 A receptor type PTPase; contains Band (94%) 4.1-like and catalytic phosphatase domains; contains SH3 and DHR (PDZ) mot Homo sapiens vitamin D receptor- interacting protein (DRIP92) mRNA, IPI:IPI00023176.2 GP:AF106934_1 complete cds; 92 kDa component of the W.DLHSIPSEHHEAITCLEWD.Q 2 2.620 0.080 O (94%) DRIP coactivator complex for the vitamin D3 receptor. Homo sapiens otoferlin (OTOF) mRNA, complete cds; similar to Caenorhabditis GP:AF107403_1 Y.KVPLPEDVSREAGYDSTYG.M 2 2.508 0.229 G elegans FER-1; mutated in DFNB9, a nonsyndromic form of deafness.
Supplementary Table 2 21 Homo sapiens voltage-gated sodium IPI:IPI00185654.1 GP:AF109737_1 channel alpha subunit SCN12A I.IPLVMEMKRGSETQEELGILT.S 2 2.532 0.234 A (93%) (SCN12A) mRNA, complete cds. Homo sapiens nuclear mitotic apparatus IPI:IPI00180749.1 GP:AF110460_1 Q.SMAFSILNTPKKLGNSLLRR.G 2 2.235 0.153 O protein 1 (NUMA1) gene, partial cds. (91%) Homo sapiens clone 2c immunoglobulin GP:AF110483_1 E heavy chain (IGE) mRNA, partial cds; Q.GLEWMGNIYPADSDTRY.S 2 2.416 0.103 G VH-Ce. Homo sapiens Ran binding protein 11 mRNA, complete cds; similar to IPI:IPI00186727.1 GP:AF111109_1 F.NEPINQIATQIAVLIAKVAR.L 2 2.308 0.144 A Schizosaccharomyces pombe Lph2p; (97%) RanBP11. Homo sapiens PRO0066 mRNA, GP:AF113007_1 A.GPSGKLSLLEVGCGTGAN.F 1 2.299 0.088 P complete cds; HQ0066. Homo sapiens clone FLB5214 PRO1359 GP:AF113694_1 mRNA, complete cds; predicted protein V.SLRALLLALRQK.P 2 2.355 0.144 G of HQ1359. Homo sapiens clone FLC1353 PRO3063 GP:AF113702_1 mRNA, complete cds; predicted protein V.HTVMTLEQQDMVCYTAQTLVR.I 2 2.653 0.088 G of HQ3063. Homo sapiens clone sc6 immunoglobulin GP:AF115125_1 heavy chain variable region mRNA, N.KHYADSVK.G 1 1.908 0.156 G partial cds. Homo sapiens clone SBOL1 lambda 1 GP:AF115349_1 immunoglobulin light chain variable I.SCSGSSSNIGKNYVSWYQQIPGTSP.K 2 2.454 0.115 P region mRNA, partial cds. Mus musculus renal munc13 mRNA, complete cds; similar to Homo sapiens IPI:IPI00183768.1 GP:AF115848_1 Q.QLRVQLEKMFEAMGGKELDSEAADSLK.E 2 2.284 0.173 A Munc13 encoded by Genbank Accession (92%) Number AF020202. Homo sapiens T-cell activation protein GP:AF116272_1 F.LLPVINEMREDIASLT.R 1 2.021 0.085 A (PGR1) gene, complete cds. Homo sapiens astrotactin2 (ASTN2) IPI:IPI00024390.1 GP:AF116574_1 S.STVVSLEWVDVQPAIGTK.V 2 2.458 0.139 G mRNA, complete cds. (98%) Homo sapiens bright and dead ringer GP:AF116846_1 gene product homologous protein Bdp S.LFGYSPAAATAAAAAGAPALLSPPK.I 2 2.255 0.333 A mRNA, complete cds. Homo sapiens znf-xp protein mRNA, GP:AF117233_1 Q.RGYCIYGDRCR.Y 1 1.819 0.084 A complete cds; ad-ZNF127-xp. Homo sapiens PDZ domain-containing IPI:IPI00074482.1 GP:AF117947_1 guanine nucleotide exchange factor I N.THLKRFEDIVNQETFWV.A 2 2.403 0.111 G (98%) mRNA, complete cds; PDZ-GEFI. Homo sapiens orphan G protein-coupled IPI:IPI00027005.1 GP:AF118266_1 receptor GPR45 (GPR45) gene, G.STQLPAPLRISLAIVMLLMTV.V 2 2.450 0.143 A (95%) complete cds. Homo sapiens histone acetyltransferase MORF beta mRNA, alternative splice product, complete cds; MOZ-related IPI:IPI00007837.1 GP:AF119231_1 P.SSLPPPTPISGQSPSSQK.S 1 2.053 0.126 A factor (MORF) beta; similar to monocytic (93%) leukemia zinc finger protein; alternatively spliced. Homo sapiens PRO1004 mRNA, GP:AF119841_1 complete cds; predicted protein of S.YEVPDHDNWPKGAGDLSV.V 1 2.115 0.081 O HQ1004. Homo sapiens PRO1855 mRNA, GP:AF119857_1 complete cds; predicted protein of L.LLLLLFGVAGGLVACRVTELQQQP.L 2 2.521 0.109 G HQ1855. Homo sapiens GTP-binding protein NGB GP:AF120334_1 C.KQLKRAALGRMCTVIKRQKQSL.E 2 2.428 0.147 O mRNA, complete cds. Homo sapiens nasopharyngeal carcinoma susceptibility protein LZ16 IPI:IPI00184470.1 GP:AF121775_1 L.LRYGGNPQQ.S 2 2.473 0.140 O mRNA, complete cds; expression down- (94%) regulated in some tumors. Homo sapiens autocrine motility factor IPI:IPI00221223.1 GP:AF124145_1 M.HTLAFMAAESLL.V 2 2.488 0.233 P receptor (AMFR) mRNA, complete cds. (95%) Homo sapiens single-strand selective IPI:IPI00168160.1 GP:AF125182_1 monofunctional uracil DNA glycosylase S.GRNLTPAELPAKQREQL.L 1 2.254 0.096 G (98%) mRNA, complete cds; SMUG1. Homo sapiens isolate 1450 immunoglobulin lambda light chain GP:AF127124_1 R.NDNRPSGISER.F 2 2.416 0.159 O variable region (IGL) gene, partial cds; IGLV. Drosophila melanogaster cactus kinase IKK mRNA, complete cds; GP:AF128403_1 D.YKIPEPILSILSRK.F 2 2.409 0.111 P serine/threonine protein kinase; similar to Homo sapiens IKK1 and IKK2.
Supplementary Table 2 22 Homo sapiens F-box protein Fbx5 (FBX5) mRNA, complete cds; contains IPI:IPI00178647.1 GP:AF129535_1 P.PRCSCSASPSAVTAAGRPR.P 2 2.310 0.128 P one F-box and one ring finger; interacts (93%) with Skp1. Homo sapiens clone FLB2205 PRO0522 GP:AF130102_1 mRNA, complete cds; predicted protein D.LLDKFYTYKVQILHLALIYF.L 2 2.469 0.143 P of HQ0522. Mus musculus 101F6 protein mRNA, GP:AF131206_1 complete cds; similar to the human L.HKEQLGKAHLTTRHGQ.A 2 2.490 0.121 O 101F6. Homo sapiens hnRNP 2H9 gene, IPI:IPI00216495.1 GP:AF132360_1 complete cds, alternatively spliced; G.QGGMSGGGWR.G 1 1.995 0.177 G (98%) involved in splicing reaction. Homo sapiens Gem-interacting protein GP:AF132541_1 (GMIP) mRNA, complete cds; interacts A.TEPPPQDFSPAPGPLTTSSQ.P 2 2.810 0.179 A with the Ras-related GTPase Gem. Homo sapiens CGI-17 protein mRNA, IPI:IPI00106698.1 GP:AF132951_1 R.IEQACDPAWSADVAAVV.M 2 2.411 0.141 G complete cds. (98%) Homo sapiens CGI-21 protein mRNA, IPI:IPI00008612.1 GP:AF132955_1 Y.FLEEDNYKNIKRPPGDIM.F 2 2.840 0.110 P complete cds. (97%) Homo sapiens thioredoxin reductase 3 IPI:IPI00013954.1 GP:AF133519_1 (TRXR3) mRNA, partial cds; K.SGKIPVNDVEQTNVPYVYAV.G 2 2.492 0.103 G (97%) selenocysteine. Homo sapiens BAC clone 215O12 NG35, NG36, G9A, NG22, G9, HSP70-2, IPI:IPI00019312.1 GP:AF134726_11 HSP70-1, HSP70-HOM, snRNP, G7A, A.SLSPTLLSTPRP.F 2 2.552 0.112 G, O (93%) NG37, NG23, and MutSH5 genes, complete cds; unknown. Homo sapiens clone IMAGE:322502 L amino acid transporter-2 (SLC7A8) IPI:IPI00005902.1 GP:AF135828_1 R.LFFAGA.R 1 1.929 0.102 A, P mRNA, partial cds; Light subunit of (91%) 4F2hc; LAT-2. Homo sapiens SH3P12 protein mRNA, IPI:IPI00217091.1 GP:AF136380_1 complete cds; c-Cbl-associated protein; G.SRSVHPNLPSDKSQDSSPL.L 2 2.434 0.167 P (94%) CAP. Homo sapiens ubiquilin 3, HOR 5'Beta14, HOR5'Beta13, HOR5'Beta12, and HOR5'Beta11 genes, complete cds; HOR 5'Beta10 and HOR5'Beta9 IPI:IPI00148948.1 GP:AF137396_7 L.SYGLILHTVAGLASQEEQRR.A 2 2.248 0.169 O pseudogenes, complete sequence; (96%) HOR5'Beta8 and HOR5'Beta7 genes, complete cds; CHR11ORF1 and amphiphysin pseudogenes, c Homo sapiens ubiquilin 3, HOR 5'Beta14, HOR5'Beta13, HOR5'Beta12, and HOR5'Beta11 genes, complete cds; HOR 5'Beta10 and HOR5'Beta9 IPI:IPI00023118.1 GP:AF137396_8 L.DFLIIFFSYILILKTVMGIGSGG.E 2 2.922 0.119 G pseudogenes, complete sequence; (95%) HOR5'Beta8 and HOR5'Beta7 genes, complete cds; CHR11ORF1 and amphiphysin pseudogenes, c Homo sapiens apolipoprotein B48 receptor (APOB48R) mRNA, complete cds; monocyte-macrophage lipoprotein GP:AF141332_1 receptor for triglyceride-rich lipoproteins; S.RVHLSRSSSQRR.S 1 1.819 0.113 A predicted molecular weight of 114.8 kDa and apparent molecular weight of about 200kDa; expressed in mo Homo sapiens GKAP/SAPAP interacting IPI:IPI00107633.1 GP:AF141901_1 protein (SHANK) mRNA, partial cds; V.MMTGYNNGRCPRNSLYSDC.I 2 2.700 0.287 G (92%) Shank2. Mus musculus Bce-1 protein (Bce-1) GP:AF141905_1 mRNA, complete cds; similar to Homo G.LDVPEMDTGCAIVPETLLLSFMLL.L 2 2.496 0.141 A sapiens BCE-1. Homo sapiens QUAKING isoform 6 GP:AF142419_1 (QUAKING) mRNA, complete cds; S.GVLGAVATKVRRHDMRVHPYQRIV.T 2 2.440 0.161 O QUAKING-6. Homo sapiens F-box protein FLR1 IPI:IPI00099395.1 GP:AF142481_1 (FLR1) mRNA, complete cds; contains F.TYEELKDIKKKVIAQH.C 2 2.802 0.093 P (96%) leucine-rich repeat. Caenorhabditis elegans R151.8A protein (R151.8A) mRNA, complete cds; GS1- like protein; 26.6 kDa; similar to Homo GP:AF143147_1 sapiens GS1 protein that escapes X- A.MPGAEKLVR.H 2 2.279 0.108 O chromosome inactivation presented in SwissProt Accession Number Q08623; similar to R151.8 ORF encoded
Supplementary Table 2 23 Homo sapiens LOMP protein mRNA, GP:AF144237_1 S.SLPRSYTMDDAW.K 1 2.056 0.170 P complete cds. Homo sapiens mucin 11 (MUC11) GP:AF147791_1 S.TTTPGLSEKSTTFHS.S 2 3.270 0.157 G mRNA, partial cds; MUC34. Homo sapiens mitofilin mRNA, partial GP:AF148646_1 cds; inner mitochondrial transmembrane F.PPQQLKPPPELCPEDINTFK.L 2 2.377 0.105 A protein. Homo sapiens Sex comb on midleg GP:AF149045_1 homolog 1 isoform 1 (SCMH1) mRNA, F.LKQGHGGEVISAVFDREQ.H 2 2.504 0.132 O complete cds; chromatin protein. Homo sapiens HSPC196 mRNA, GP:AF151030_1 L.LQKTPVIQLVLFIIQDI.A 2 2.433 0.110 P complete cds. Homo sapiens HSPC203 mRNA, GP:AF151037_1 A.FRKNKTLGYGVPMLLLIVGGSFG.L 2 2.407 0.104 O complete cds. Homo sapiens HSPC213 mRNA, IPI:IPI00155047.1 GP:AF151047_1 Y.GIISISRVDKLEQDLPLLALVPTP.A 2 2.864 0.086 A complete cds. (92%) Homo sapiens HSPC251 mRNA, GP:AF151085_1 R.DRKSSDSDSSDSESDTGKRAGHTSK.D 2 2.371 0.147 P complete cds. Homo sapiens pyrroline 5-carboxylate IPI:IPI00181181.1 GP:AF151351_1 reductase isoform (P5CR2) mRNA, Q.EKISPAALKKTLLD.R 2 3.175 0.182 O (97%) complete cds. Mus musculus DNA polymerase iota (PolI) mRNA, complete cds; formerly Rad30b; similar to Homo sapiens RAD30B encoded by GenBank GP:AF151691_1 R.DTALPSKRVSAASPC.E 1 2.038 0.148 G Accession Number AF140501; similar to Homo sapiens DNA polymerase eta encoded by Genbank Accession Numbers AB024313 and AF1 Homo sapiens CGI-53 protein mRNA, IPI:IPI00006535.2 GP:AF151811_1 R.DFTTLFD.L 1 1.892 0.180 O complete cds. (94%) Homo sapiens CGI-55 protein mRNA, GP:AF151813_1 L.HKSKSEEAHAEDSVMDHHFR.K 2 2.378 0.196 A complete cds. Homo sapiens CGI-87 protein mRNA, IPI:IPI00181009.1 GP:AF151845_1 L.EQGLAEDGGMSSVTQEG.R 1 2.054 0.081 O complete cds. (97%) Homo sapiens CGI-135 protein mRNA, GP:AF151893_1 S.EKAAGSVSKSTQFEY.A 2 2.632 0.113 P complete cds. Homo sapiens CGI-148 protein mRNA, IPI:IPI00150757.1 GP:AF151906_1 I.FAFSALFSF.R 1 2.317 0.149 A complete cds. (98%) Homo sapiens protocadherin gamma A5 IPI:IPI00215842.1 GP:AF152325_1 (PCDH-gamma-A5) mRNA, complete K.SRLLQAEGSRLAGV.P 2 2.435 0.103 G (98%) cds; member of the cadherin superfamily. Homo sapiens protocadherin gamma B4 IPI:IPI00012551.1 GP:AF152333_1 (PCDH-gamma-B4) mRNA, complete G.EVTCKLEGDVPFKILTSSRNTYK.L 2 2.203 0.209 A, P (99%) cds; member of the cadherin superfamily. Homo sapiens protocadherin gamma B7 IPI:IPI00012551.1 GP:AF152336_1 (PCDH-gamma-B7) mRNA, complete F.SDHPTPSDSQAEMQFYL.V 1 2.143 0.116 A (99%) cds; member of the cadherin superfamily. Homo sapiens chromatin-specific transcription elongation factor FACT 140 GP:AF152961_1 kDa subunit mRNA, complete cds; M.KTIVDDPEGFFEQG.G 2 3.340 0.135 O FACTp140; similar to Saccharomyces cerevisia. Mus musculus Nma (Nma) mRNA, GP:AF153440_1 complete cds; novel transmembrane G.CLDSLASTA.D 1 2.177 0.095 O protein; similar to Homo sapiens NMA. Porphyromonas gingivalis strain W50 immunoreactive 106 kDa antigen PG115 gene, complete cds; reactive with sera GP:AF153767_1 T.LKNSLLLEVFSAVMDQVYTATVR.E 2 2.446 0.203 A from human periodontitis patients and with sera from hyperimmunized rabbits; similar to zinc proteases. Homo sapiens sodium-dependent high- affinity dicarboxylate transporter I.LLMAVYWCTEALPLSVTALLPIVLFPFMGIL GP:AF154121_1 3 3.519 0.234 O (NADC3) mRNA, complete cds; NADC3; PSNK.V integral membrane transporter. Homo sapiens putative E1-E2 ATPase GP:AF156548_1 mRNA, partial cds; putative transbilayer V.YVVRSGGLVKTRSKNIRVG.D 2 2.644 0.191 O amphipath transporter; class If. Homo sapiens HSPC086 mRNA, partial GP:AF161349_1 Q.KGHYGHECPEREVY.D 2 2.404 0.177 G cds. Homo sapiens HSPC253 mRNA, partial GP:AF161371_1 F.LSRKRRRNAGKDRR.H 2 2.234 0.156 P cds. Homo sapiens HSPC269 mRNA, partial GP:AF161387_1 H.ETGIAISVAAVALGAKVLER.H 2 2.367 0.107 G cds. GP:AF161428_1 Homo sapiens HSPC310 mRNA, partial E.EIVQKIEEVLSGVL.D 2 2.682 0.292 G
Supplementary Table 2 24 cds. Homo sapiens HSPC326 mRNA, partial A.IAEGAQSLGLSSGSSQHVSGRMGSELILH IPI:IPI00187163.1 GP:AF161444_1 2 2.401 0.131 O cds. F.V (91%) Homo sapiens HSPC108 mRNA, IPI:IPI00164305.1 GP:AF161458_1 L.LPSNPGDVTSMVAQAMGVYGALT.K 2 2.422 0.214 A complete cds. (91%) Homo sapiens HSPC115 mRNA, IPI:IPI00099416.1 GP:AF161464_1 L.VAEEHLTVDARVYSYALALKH.A 2 2.404 0.155 A complete cds. (94%) Homo sapiens HSPC073 mRNA, GP:AF161558_1 D.KKSFYKIEVPLKLSVFTA.F 2 2.645 0.108 O complete cds. Mus musculus amino acid transporter B0+ (ATB0+) mRNA, complete cds; GP:AF161714_1 similar to the Homo sapiens ATB0+ F.ASFQSVLPWANCSSWADENCSRTP.I 2 2.533 0.121 O encoded by the sequence presented in GenBank Accession Number AF151978. Homo sapiens clone 3PF12 anti-HLA- A2/A28 immunoglobulin heavy chain GP:AF163307_1 G.RFTISRDNSKKTVSLQ.M 2 3.008 0.129 P variable region mRNA, partial cds; VH region. Homo sapiens FT002 (FT002) mRNA, GP:AF167351_1 complete cds; similar to Mus musculus R.LQSGVNIL.Q 1 2.146 0.097 G bromodomain-containing protein BP75. Homo sapiens clone case04H1 GP:AF168802_1 immunoglobulin heavy chain variable Q.LVESGGALVQPGGSLR.L 2 2.273 0.126 G region gene, partial cds. Homo sapiens potassium-dependent Na/Ca exchanger NCKX3 (SLC24A3) mRNA, partial cds; similar to Mus GP:AF169257_1 musculus protein in GenBank Accession N.GTGPSSAPDRGV.N 2 2.556 0.107 O Number AF314821 and to Rattus norvegicus protein in GenBank Accession Number AY009158. Homo sapiens gamma-synergin mRNA, GP:AF169548_1 complete cds; contains 1 EH domain; M.ALRPGAGSGGGGAAGAGAGSA.G 1 2.400 0.083 G binds gamma-adaptin. Homo sapiens cell cycle checkpoint GP:AF170724_1 protein CHFR mRNA, complete cds; G.QLLVAQPRRNAQTVHEDVRAAAGK.P 3 3.684 0.121 O contains FHA domain and ring finger. Homo sapiens GR AF-1 specific protein GP:AF174498_1 phosphatase mRNA, partial cds; similar K.FESINDETELEALCAEIA.S 2 2.458 0.125 O to human type II protein phosphatase. Homo sapiens MOT8 mRNA, complete GP:AF175409_1 A.LLRRGKRHLQGDGLSSFDSRGSR.P 2 2.382 0.199 P cds; hypothetical. Homo sapiens tropomodulin 2 (TMOD2) IPI:IPI00005089.1 GP:AF177169_1 L.DPELEEALASASDTELYDLAA.V 2 2.500 0.189 P mRNA, complete cds. (94%) Homo sapiens tropomodulin 3 (TMOD3) IPI:IPI00005087.1 GP:AF177171_1 L.PAGFRQKNQTSKSTTGPFDR.E 2 2.306 0.171 A mRNA, complete cds. (95%) Homo sapiens GTPase-activating protein 6 isoform 4 (ARHGAP6) mRNA, GP:AF177663_1 E.RARLQEVAF.Y 2 2.402 0.102 A alternatively spliced, complete cds; alternatively spliced. Homo sapiens herstatin (HER-2) mRNA, alternatively spliced, complete cds; IPI:IPI00038700.1 GP:AF177761_1 approximately 68 kDa secreted T.SVPISPVSVGRGPDPDAHVA.V 2 2.792 0.156 A (93%) autoinhibitor glycoprotein; alternatively spliced. Mus musculus deleted in liver cancer 1 (Dlc-1) mRNA, complete cds; DLC-1 GP:AF178078_1 protein; similar to Homo sapiens deleted L.RRENSSHSPKELKR.R 2 2.548 0.090 G in liver cancer 1 and Rattus rattus RhoGAP. Mus musculus transcription factor GATA- 4 (Gata4) mRNA, complete cds; similar GP:AF179424_1 A.AREAAAYGSGGGAAGAGLAGREQYG.R 2 2.464 0.130 A to Rattus norvegicus, Gallus gallus and Homo sapiens GATA-4. Mus musculus transcription factor GATA- 6 (Gata6) mRNA, complete cds; similar A.SADSPPYGGGGAAGGGAAGPGGAGSAT GP:AF179425_1 2 2.462 0.269 P to Rattus norvegicus, Gallus gallus and AHAS.A Homo sapiens GATA-6. Homo sapiens B cell linker protein IPI:IPI00002434.1 GP:AF180756_1 I.HPTESSSPPPEKAPMVNR.S 1 2.241 0.133 A (BLNK) gene, exon 17 and complete cds. (91%) Xenopus laevis zinc-finger transcription factor (Blimp1) mRNA, complete cds; GP:AF182280_1 involved in early development; similar to S.SPHSSPGSAVSPHHPVQDHK.E 2 2.517 0.156 A Homo sapiens PRDI-BF1 and Mus musculus Blimp-1. GP:AF183185_1 Homo sapiens brain otoferlin long Y.RAEGLPR.M 1 1.888 0.102 O, P IPI:IPI00030025.2
Supplementary Table 2 25 isoform (OTOF) mRNA, complete cds; (91%) FER-1-like protein. Homo sapiens putative N- GP:AF185571_1 acetyltransferase Camello 2 (CML2) R.DQGYSEVVLDTSNIQLSAMGL.Y 2 2.682 0.089 O mRNA, complete cds. Canis familiaris breed beagle melanoma GP:AF187325_1 antigen mRNA, complete cds; MAGE; V.PKTGLLMTILGV.I 2 2.524 0.117 G similar to Homo sapiens MAGE. Homo sapiens TGF-beta resistance- IPI:IPI00097940.1 GP:AF188125_1 associated protein TRAG (TRAG) L.LDRKDKELLICPPVT.R 2 2.456 0.166 P (94%) mRNA, partial cds. Homo sapiens clone pGR2HL14 galanin- GP:AF188492_1 like peptide precursor, mRNA, complete V.METFAKPEIGDLGMLSMKIP.K 2 2.463 0.124 A cds; neuropeptide. Homo sapiens voltage-gated sodium channel type XI alpha subunit (SCN11A) S.FRVLRVFKLAKSWPTLNTLIKIIGNSVGALG IPI:IPI00185654.1 GP:AF188679_1 3 3.785 0.134 O mRNA, complete cds; NaN alpha SLTVVL.V (93%) subunit; TTX-R sodium channel. Homo sapiens leucine-rich repeat- IPI:IPI00219888.1 GP:AF190500_1 containing G protein-coupled receptor 7 F.GKYFSHGGGQDVKCSLGYFPCGNITK.C 3 3.505 0.103 O (95%) (LGR7) mRNA, complete cds. Homo sapiens anaphase-promoting IPI:IPI00180406.1 GP:AF191339_1 complex subunit 5 (APC5) mRNA, R.LYGRSTMALQQAQMLLS.M 2 2.530 0.188 P (97%) complete cds. Homo sapiens COP9 complex subunit 7a GP:AF193844_1 P.EQHLTELREPAPGTNQRHPSKKASKGK.G 2 2.251 0.297 A mRNA, complete cds; COPS7a. Homo sapiens clone 8HC immunoglobulin heavy chain variable GP:AF193848_1 region mRNA, partial cds; Fab I.FGSANYAQK.F 2 2.327 0.106 O monoclonal antibody against preS1 of hepatitis B virus. Homo sapiens clone 912 immunoglobulin GP:AF194570_1 lambda light chain variable region S.SHAGNNNVIFGGGTK.L 2 2.496 0.120 G mRNA, partial cds. Homo sapiens clone 1212 IPI:IPI00186348.1 GP:AF194667_1 immunoglobulin lambda light chain G.LAPVLVIYEDSK.R 2 2.343 0.167 O (97%) variable region mRNA, partial cds. Homo sapiens clone 730 immunoglobulin IPI:IPI00186348.1 GP:AF194696_1 lambda light chain variable region -.SYELTQPPSVSVSPGQTARITCCGD.A 2 4.140 0.397 G (94%) mRNA, partial cds. Homo sapiens clone 5/17/04 GP:AF195315_1 immunoglobulin V lambda/J lambda light K.LTIYEVSNRPSGVPDR.F 2 2.307 0.158 G chain gene, partial cds. Homo sapiens clone 20/3/07 GP:AF195354_1 immunoglobulin V lambda/J lambda light V.SRRPSGVPDR.F 2 2.246 0.144 P chain gene, partial cds. Homo sapiens DNA mismatch repair IPI:IPI00218050.1 GP:AF195657_1 V.ETPDIKDLASTL.S 1 2.290 0.093 G protein (MLH3) mRNA, complete cds. (96%) Homo sapiens L2DTL protein (L2DTL) mRNA, complete cds; contains WD-40 IPI:IPI00100488.1 GP:AF195765_1 G.FYRQVNQISGAHNTSDKQTPSKPKKK.Q 2 2.204 0.160 O repeats; similar to the Drosophila lethal (91%) (2) denticleless heat shock gene, l(2)dtl. Homo sapiens SUMO-1 specific protease GP:AF199459_1 K.ETIQGTGSWGPEPPGPGIPPAYSSPRR.E 2 2.569 0.146 A, G 3 (SSP3) mRNA, complete cds. Homo sapiens clone 3B.11 T cell GP:AF200429_1 receptor beta chain mRNA, partial cds; F.GGGGLTGELFFGEGSRLTV.L 2 2.467 0.112 O TCR BV5S2J2S2C2. Leishmania tropica ABC1 transporter GP:AF200948_1 (abc1) gene, complete cds; similar to P.VFLFITLFIDHPGRR.Q 2 2.351 0.145 A human ABC1 transporter. Taphozous sp. Brca1 (Brca1) gene, GP:AF203748_1 partial cds; similar to exon 11 of Homo V.KTISKKNLSEEKFEKQ.S 2 2.406 0.146 G sapiens BRCA1. Hipposideros commersoni RAG 1 (RAG IPI:IPI00013914.1 GP:AF203760_1 1) gene, partial cds; similar to exon 1 of F.ARRLMTKETVEAVCELLPSQ.E 2 2.554 0.134 P (95%) Homo sapiens RAG1. Homo sapiens transposon-derived Buster1 transposase-like protein mRNA, IPI:IPI00009655.1 GP:AF205600_1 complete cds; similar to transposase of L.CEEMGAQHTALLLNTEVR.W 2 2.441 0.200 P (97%) Charlie1 hAT-like DNA transposon; Buster1 protein. Homo sapiens zinc finger protein 106 IPI:IPI00008283.1 GP:AF205632_1 K.QADTATSKVSGKN.G 1 2.004 0.104 O (ZFP106) mRNA, complete cds. (93%) Homo sapiens protein translocase, JM26 G.GGPGDALGAAAAGVGAAGVVVGVGGAV GP:AF207550_5 protein, UDP-galactose translocator, pim- 2 2.858 0.168 P GV.G 2 protooncogene homolog pim-2h, and
Supplementary Table 2 26 shal-type potassium channel genes, complete cds; JM12 protein and transcription factor IGHM enhancer 3 genes, partial cds; and unknown Homo sapiens tumor-associated hydroquinone (NADH) oxidase tNOX mRNA, complete cds; pan cancer cell GP:AF207881_1 surface hydroquinone (NADH) oxidase R.RLVNEKAAHEK.D 2 2.563 0.236 A with protein disulfide-thiol isomerase activity; tNOX is found to be present in most types of transformed cells as Homo sapiens IL-17 receptor homolog IPI:IPI00220930.1 GP:AF208110_1 precursor (EVI27) mRNA, complete cds; A.CKKNEETVEVNFTTTPLGNR.Y 2 2.329 0.101 O (94%) EVI27A. Homo sapiens IMPACT (IMPACT) GP:AF208694_1 mRNA, complete cds; ortholog of mouse D.DLILACQPESSLKAL.D 2 2.774 0.101 P imprinted gene Impact. Homo sapiens isolate 4 Miller-Dieker IPI:IPI00218728.1 GP:AF208838_1 lissencephaly protein (MDCR) mRNA, R.DPKGWIPRPPEKYALSGHR.S 2 2.327 0.108 O (99%) complete cds. Homo sapiens BM-008 mRNA, complete GP:AF208850_1 F.LITHNPTNATLN.K 1 2.024 0.136 G cds. Homo sapiens BM-019 mRNA, complete IPI:IPI00010248.1 GP:AF208861_1 S.GPVDPMMADAIDFMVDR.L 2 2.210 0.195 A cds. (96%) Homo sapiens Apobec-1 IPI:IPI00146939.1 GP:AF209192_1 complementation factor mRNA, complete A.YTTYEVY.P 1 2.059 0.087 A (91%) cds; ACF; Apo-B RNA editing protein. Homo sapiens clone C4 immunoglobulin light chain variable region mRNA, partial IPI:IPI00024136.1 GP:AF209864_1 H.WPATFGQGTK.V 2 2.389 0.274 G cds; anti-epithelial glycoprotein-2 (91%) antibody. Homo sapiens immunoglobulin heavy GP:AF209887_1 chain variable region 194-80 mRNA, Y.YCAQDRDSRGSGTW.G 2 2.464 0.262 A partial cds. Homo sapiens CDA08 mRNA, complete L.SKGYTKNDFAIHTLKNNFEADAYFVKVIVLS IPI:IPI00006547.1 GP:AF212247_1 3 3.839 0.208 G cds. GLCSN.D (97%) Homo sapiens bromodomain protein CELTIX1 mRNA, complete cds; similar to IPI:IPI00017462.1 GP:AF213969_1 L.KLVLKVGGNEVTELSTGSSGHDSSL.F 2 2.588 0.241 O Mus musculus bromodomain-containing (92%) protein BP75. Mus musculus TERF1-interacting nuclear GP:AF214013_1 protein 2 (Tin2) mRNA, complete cds; P.ASLRFAAAASWLVVR.R 2 2.584 0.116 P TIN2; similar to homo sapiens TIN2. Mus musculus ancient conserved domain protein 2 (Acdp2) mRNA, complete cds; IPI:IPI00161046.1 GP:AF216961_1 T.PLRDCFMITGEAILDF.N 2 2.566 0.257 O similar to Homo sapiens ACDP2; (92%) mACDP2. Homo sapiens MLEL1 protein (MLEL1) N.WGRDGGPRSSGGGYGGGPAGGHGGNR. IPI:IPI00027415.1 GP:AF217190_1 2 2.488 0.308 O mRNA, complete cds. G (91%) Canis familiaris heparan sulfate sulfamidase (SGSH) mRNA, complete cds; lysosomal exohydrolase; heparin IPI:IPI00184987.1 GP:AF217203_1 sulfamidase; when inactive results in the A.LGLCRPLGARPRNVLLIVADDGGFESG.A 2 2.488 0.297 A (91%) human disease Sanfilippo syndrome type A and a similar pathologic phenotype in dog. Homo sapiens zinc finger protein GP:AF217227_1 ZNF287 (ZNF287) mRNA, complete cds; L.YKTVTLQ.N 1 2.118 0.098 P Kruppel-subfamily member. Mus musculus putative repair and recombination helicase RAD26L mRNA, partial cds; similar to Saccharomyces R.CLAPSLDNKKLCEASIKSITVDGNGKPFAV GP:AF217319_1 3 3.673 0.125 P cerevisiae RAD26, Homo sapiens VLYPD.F ERCC6 and chromodomain helicase proteins of the SNF2 family.. Homo sapiens helicase-like protein NHL IPI:IPI00219851.1 GP:AF217795_1 A.PGSTGATFLAVCRGK.A 2 2.324 0.140 P mRNA, complete cds. (95%) Homo sapiens disrupted in GP:AF222980_1 Schizophrenia 1 protein (DISC1) mRNA, S.SRNVKKLGSVKEDYNR.L 2 2.456 0.131 G complete cds. Homo sapiens HT015 protein (HT015) IPI:IPI00163676.1 GP:AF223466_1 V.GSQAVAR.R 1 1.814 0.227 A mRNA, complete cds. (92%) Homo sapiens AD022 protein (AD022) IPI:IPI00009913.2 GP:AF223469_1 L.GSCLEGGREAAEEE.G 2 2.664 0.088 O mRNA, complete cds. (95%) Homo sapiens PMEPA1 protein IPI:IPI00183659.1 GP:AF224278_1 R.MEGPPPTYSEVIGH.Y 1 1.907 0.144 A (PMEPA1) mRNA, complete cds; type 1b (94%)
Supplementary Table 2 27 transmembrane protein; expression is induced in response to the synthetic androgen, R1881; expression is abundant in, and restricted to, prostate glandular epithelial cells; similar to Homo sapiens tensin mRNA, complete IPI:IPI00019457.1 GP:AF225896_1 I.QPEEDEGKVVVRLSEEPR.S 2 2.262 0.110 G cds. (94%) Homo sapiens GK001 (GK001) mRNA, GP:AF226054_1 L.LVFGSVSEAK.F 1 1.881 0.111 P complete cds. Homo sapiens Cyt19 mRNA, complete IPI:IPI00184281.1 GP:AF226730_1 A.QKIGFCPPRLVTANLITIQN.K 2 2.755 0.175 G cds. (99%) Homo sapiens NPD007 mRNA, complete GP:AF226732_1 V.FSREEGSPEPETEPGAW.L 2 2.998 0.155 A cds. Homo sapiens RB-associated KRAB GP:AF226869_1 repressor (RBAK) mRNA, complete cds; E.NEDKHSRQAACINSKTL.T 1 2.004 0.126 G transcriptional repressor. Homo sapiens UDP-glucose:glycoprotein IPI:IPI00024467.1 GP:AF227906_1 glucosyltransferase 2 precursor, mRNA, D.DEVDGANDAGV.A 1 2.277 0.112 P (96%) complete cds; HUGT2. Homo sapiens clone OSGE GP:AF228324_1 immunoglobulin light chain variable R.HNLAWYQQR.P 2 2.234 0.146 P region gene, partial cds; unmutated. Homo sapiens leucine rich repeat and death domain containing protein (LRDD) mRNA, complete cds; protein has a IPI:IPI00168356.1 GP:AF229178_1 death domain at the carboxyl-terminus D.RQDVAEEVRAVLELGRRKYQDSIRR.M 2 2.270 0.248 G (94%) and leucine rich repeats at the amino- terminus and a ZU5 domain in the intermediate region.. Homo sapiens BAC 137K3 chromosome 8 map 8q24.3 containing part of gene for IPI:IPI00000928.1 GP:AF230666_2 CGI-72 protein and part of thyroglobulin Q.EDLAKPLSVGLDSNSSTGTPEAAK.K 2 2.271 0.271 O (95%) gene, complete sequence; matrix protein for thyroid hormone synthesis. Hordeum vulgare human tumor protein- E.LENGVLWEVDGHWVVQGAVDVDIGANP. GP:AF230786_1 2 3.466 0.137 G like protein mRNA, complete cds; HTP. S Homo sapiens zinc finger transcription IPI:IPI00154612.1 GP:AF230808_1 factor Pegasus mRNA, complete cds; V.SAVSASIPQSSSPTSP.E 1 2.018 0.131 G (92%) similar to Ikaros. Homo sapiens MIP-T3 mRNA, complete GP:AF230877_1 cds; microtubule-interacting protein that K.ARARPDNERQKDRGNRER.D 2 2.360 0.108 P associates with TRAF3. Homo sapiens chromosome 21 unknown mRNA; similar to genomic sequence K.TELNSSAESEQPLDKTGHVKDTNQEDGVII GP:AF231920_1 3 3.614 0.102 P deposited in GenBank Accession SEHGEDEM.D Number AP000038. Homo sapiens clone BL44 IPI:IPI00022862.1 GP:AF233254_1 immunoglobulin light chain variable N.LAWYQQNPGQAPR.L 2 2.412 0.246 G (94%) region mRNA, partial cds. Homo sapiens chromosome 8 map 8q24.3 PAC RP6-98A24, complete IPI:IPI00009499.1 GP:AF235100_1 sequence, containing part of the L.DSDFLAVLSDYPSPDIS.P 2 2.627 0.123 G (92%) thyroglobulin (TG) gene and part of the gene for Src-like adapter protein. Homo sapiens clone a20a17 immunoglobulin heavy chain variable V.TISVDTSKNQFSLKLSSVTAADTAVYYCAT GP:AF235534_1 3 3.829 0.254 G region gene, partial cds; VH gene family FSYY.Y 4; unmutated. Homo sapiens clone c29a25 immunoglobulin heavy chain variable GP:AF235774_1 K.NTPYLQMNSLR.A 1 1.895 0.149 G region gene, partial cds; VH gene family 3; mutated. Homo sapiens clone d3a19 immunoglobulin heavy chain variable GP:AF235827_1 S.RDNAKNSLYLQMRSLR.A 2 2.352 0.102 P region gene, partial cds; VH gene family 3, mutated. Homo sapiens clone d4a17 immunoglobulin heavy chain variable IPI:IPI00018563.3 GP:AF235850_1 K.SISTAYLQWSSLR.A 2 2.495 0.227 G region gene, partial cds; VH gene family (93%) 5, mutated. Homo sapiens CYP4F11 mRNA, IPI:IPI00059634.1 GP:AF236085_1 V.LALTLLHFRILP.T 1 2.013 0.139 G complete cds; P450. (94%) Homo sapiens filamen B (FLNB) mRNA, IPI:IPI00029489.2 GP:AF238609_1 A.RRLTVVSLQESGLKVNQPASFAIR.L 2 2.375 0.130 P partial cds. (99%) Homo sapiens hypothetical nuclear factor GP:AF242524_1 E.KVKKEAEKRPADK.M 2 2.285 0.105 G SBBI22 mRNA, complete cds.
Supplementary Table 2 28 Homo sapiens zinc finger protein 291 GP:AF242528_1 T.ARNLIAWSVPLESKDDDGK.P 2 2.224 0.181 P (ZNF291) mRNA, complete cds. Homo sapiens sodium bicarbonate IPI:IPI00105992.2 GP:AF243499_1 cotransporter NBC4a (NBC4) mRNA, M.ESVQSDPQNGIHCIARKRS.S 2 3.233 0.169 G (96%) complete cds. Homo sapiens vacuolar proton pump 116 kDa accessory subunit (ATP6N1B) mRNA, complete cds, alternatively IPI:IPI00009852.1 GP:AF245517_1 A.LKQSFLELTELK.Y 2 2.328 0.109 A spliced; ATPase; lacks exon 3; (94%) translation start in exon 4; alternatively spliced. Homo sapiens grap2 cyclin D interacting IPI:IPI00015923.1 GP:AF246144_1 T.APAAAVPTLASPLEQLRHLA.E 2 2.482 0.165 A protein GCIP mRNA, complete cds. (95%) Homo sapiens clone C63R unknown P.PPSTNPFLEDEPTPEMEELATEKGDLDQP IPI:IPI00221275.1 GP:AF246287_1 2 2.346 0.116 O mRNA. KK.P (98%) Homo sapiens mitochondrial ceramidase mRNA, complete cds; nuclear gene for IPI:IPI00181368.1 GP:AF250847_1 Q.PGIYRIRYFGHNRK.Q 1 2.044 0.091 G mitochondrial product; active in neutral to (95%) alkaline range. Homo sapiens cyclophilin-like protein GP:AF251049_1 mRNA, complete cds; PPIL3; M.KYTVFGKVIDGLETLDELEK.L 3 3.564 0.080 A alternatively spliced. Homo sapiens parathyroid hormone GP:AF251060_1 P.APGKPGVGGGSVLTR.G 2 2.460 0.143 O mRNA, complete cds. Homo sapiens hCLA-iso mRNA, GP:AF251294_1 G.AKKAKADSPVNGLPKGR.E 2 2.618 0.205 O complete cds. Homo sapiens ser/arg-rich pre-mRNA R.RSRSTDRRRGGSRRSRSREKRRRRRRS GP:AF254411_1 splicing factor SR-A1 (SR-A1) gene, 3 3.631 0.111 O ASPPPA.T complete cds. Homo sapiens predicted testis protein GP:AF254756_1 A.ERSYKSQISTLHKSVVKMEEEL.Q 2 2.646 0.239 G (TSGA10) mRNA, complete cds. Homo sapiens G-protein-coupled IPI:IPI00217954.1 GP:AF257182_1 receptor 48 (GPR48) mRNA, complete W.FIFLVALFFNLLVILTTFASCTSLPSSKLF.I 2 2.467 0.112 A (95%) cds. Homo sapiens histone acetyltransferase (MOF) mRNA, partial cds; in vitro histone IPI:IPI00103685.1 GP:AF260665_1 Y.WKGQHVICVTPKLVEEHLKS.A 2 2.523 0.260 G acetyltransferase activity directed toward (96%) histone H4. Homo sapiens acyl-CoA dehydrogenase GP:AF260689_1 8 (ACAD8) gene, exon 11 and complete I.FEDCAVPVANRIG.S 1 2.160 0.158 G cds; isobutyryl-CoA dehydrogenase. Homo sapiens clone cp2-009 GP:AF262077_1 immunoglobulin heavy chain variable K.SRVSISVDMTK.N 2 2.282 0.113 G region mRNA, partial cds. Homo sapiens clone cp1-hb1-7 GP:AF262208_1 immunoglobulin heavy chain variable V.TMSVDTPKNQFSLMLSSVTAAETA.I 2 2.419 0.101 P region mRNA, partial cds. Homo sapiens scavenger receptor cysteine-rich type 1 protein M160 IPI:IPI00026975.1 GP:AF264014_1 R.ISSTAEETW.I 1 1.982 0.082 O precursor, mRNA, complete cds, (99%) alternatively spliced. Homo sapiens sporulation-induced transcript 4-associated protein SAPLa IPI:IPI00019540.1 GP:AF264779_1 L.EAIRGRLGSFHELLLEP.P 2 2.459 0.192 G (C11orf23) mRNA, complete cds, (95%) alternatively spliced; isoform a. Homo sapiens golgin-like protein (GLP) GP:AF266285_1 V.LHRRLQQTIKE.R 2 2.879 0.164 O gene, complete cds. Homo sapiens clone IgA5019 GP:AF267765_1 immunoglobulin A heavy chain mRNA, V.TTMVGGTVTRFDYWGQG.- 1 2.077 0.129 G partial cds; IgA VH; CDR3 sequence. Homo sapiens DC44 mRNA, complete IPI:IPI00171769.1 GP:AF267862_1 S.LEVSLDGAQVSYSR.R 2 2.302 0.118 G cds. (95%) Homo sapiens amyloid lambda 6 light GP:AF267873_1 chain variable region NEG mRNA, partial N.SVQWYQQR.P 2 2.451 0.192 G cds. Homo sapiens muscle-specific protein IPI:IPI00009897.1 GP:AF267997_1 (C4orf5) gene, exon 4 and complete cds; I.AMQNGKVDGSNLEGG.S 2 2.829 0.108 P (92%) muscle specific. Homo sapiens rhophilin-like protein IPI:IPI00216714.1 GP:AF268032_1 mRNA, complete cds; RL; rho effector A.IDDDNKTDKTKKISKKLS.F 2 2.521 0.131 P (92%) protein. Homo sapiens IRA1 mRNA, complete GP:AF268193_1 cds, alternatively spliced; alternatively W.NAAGDKVGASASDGSVCVLD.L 1 2.114 0.102 P spliced. Homo sapiens breast cancer antigen NY- IPI:IPI00043069.1 GP:AF269087_1 T.HQKEMDKISGKLEDSTSLSKI.L 2 2.503 0.111 G BR-1 mRNA, complete cds; putative (98%)
Supplementary Table 2 29 transcription factor. Homo sapiens arsenite related gene 1 IPI:IPI00030845.1 GP:AF269167_1 mRNA, complete cds; ARG1; elevated S.KLQTEVKEGKETSSKLEKETCKK.S 2 2.252 0.102 G (96%) expression when induced with arsenite. Homo sapiens hepatocellular carcinoma- GP:AF271350_1 V.MYCTRTARLRTEPWRLLKLRLCRWRR.I 3 3.526 0.108 P associated gene TD26 mRNA. Homo sapiens cyclophilin-like protein A.LCASNYYNGCIFHRNIKGFMVQTGDPTGT GP:AF271652_1 PPIL3b (PPIL3) mRNA, complete cds, 3 3.642 0.101 A GR.G alternatively spliced; alternatively spliced. Homo sapiens Dvl-binding protein IDAX GP:AF272159_1 mRNA, complete cds; inhibition of the M.NLPERVGTFSAIPALGGI.S 2 2.555 0.100 A Dvl and Axin complex. Homo sapiens PR-domain zinc finger protein 6 isoform A (PRDM6) mRNA, IPI:IPI00219073.1 GP:AF272898_1 partial cds; alternatively spliced; C.AVVKPTCPAGKLPERGTKEPGR.G 2 2.338 0.202 A (97%) alternatively spliced; PR-domain family protein 3 isoform A; PRDM6A; PFM3A. Homo sapiens EAF1 mRNA, complete GP:AF272973_1 I.EQMSSSSGSSSSDSESS.S 2 2.419 0.112 P cds; interacts with ELL. Homo sapiens kelch-like 5 protein IPI:IPI00044609.2 GP:AF272976_1 G.CTNLCAVLFARCLDDHLVSLRMSGSRK.E 2 2.347 0.168 G, O (KLHL5) mRNA, complete cds. (96%) Carassius auratus gibelio cyclin B mRNA, complete cds; similar to cyclin B GP:AF273494_1 Q.FLRRASKIGDVTAEHHTLAK.Y 2 2.242 0.136 O in Homo sapiens, Mus musculus and Xenopus laevis. Homo sapiens secretory pathway component Sec31B-1 mRNA, alternatively spliced, complete cds; IPI:IPI00023442.1 GP:AF274863_1 p137h; Sec31B; similar to yeast Sec31p; V.IVGGGDNGMLILY.N 1 2.034 0.114 O (93%) mammalian COPII coat component; also found at plasma membrane; contains WD repeats and proline-rich domains. Homo sapiens transmembrane-type GP:AF275150_1 protein tyrosine phosphatase H (PTPRH) V.RNLHMETQTNSSIALCWEVPDG.P 2 2.506 0.157 O gene, exon 20 and complete cds. Homo sapiens putative carotene dioxygenase mRNA, complete cds; IPI:IPI00168196.1 GP:AF276432_1 similar to the retinal pigment epithelial P.CVAPLLTTVEEAPR.G 2 2.338 0.188 G, O (99%) protein RPE65; putative carotene cleavage enzyme. Homo sapiens putative Listeria-induced GP:AF277289_1 protein LIND mRNA, complete cds; 38.9 M.KELYERKVAELK.T 2 2.280 0.149 A kDa; contains three coil-coil domains. Homo sapiens chemokine-like factor-like protein CKLFH1a (CKLFH) mRNA, GP:AF278577_1 V.CCIDAFVVTTKMRTNL.K 1 2.117 0.083 G complete cds, alternatively spliced; cytokine; alternatively spliced. Homo sapiens putative anion transporter GP:AF279265_1 1 mRNA, complete cds; similar to CLD, V.NTSLEDMRSNNVED.C 1 2.220 0.114 A PDS, and DTDST anion transporters. Mus musculus anti-human-HLA-DR K.SPQLLVSNAKTLAEGVTSRFSGSGSGKQF GP:AF281860_1 immunoglobulin kappa light chain 3 3.605 0.125 O SLKINSLQ.P variable region mRNA, partial cds. Homo sapiens chronic myelogenous leukemia tumor antigen 66 mRNA, IPI:IPI00219201.1 GP:AF283301_1 L.KTTHVVNLGSNQYL.F 2 2.689 0.126 O, P complete cds, alternatively spliced; (99%) CML66; alternatively spliced. Homo sapiens folate transporter/carrier mRNA, complete cds; nuclear gene for IPI:IPI00157683.1 GP:AF283645_1 mitochondrial product; MFT; six P.NIWGAGLSWGLYFFFYNAIK.S 2 2.204 0.112 P (96%) transmembrane domain transport protein. Homo sapiens complement factor MASP- IPI:IPI00180655.1 GP:AF284421_1 V.TVYLGLHDVRDK.S 2 2.281 0.199 A 3 mRNA, complete cds. (98%) Homo sapiens testis protein TEX13A K.EGDLRSVETATSYFSGTTNPWSRASSEPL GP:AF285597_1 3 3.507 0.087 A (TEX13A) mRNA, complete cds. PVQLPAS.Y Homo sapiens MOV10-like 1 (MOV10L1) IPI:IPI00182372.1 GP:AF285604_1 F.TAEMSDWVDEIQTPKARKMEFFNP.V 2 2.431 0.167 A mRNA, complete cds; helicase. (99%) Homo sapiens hepatocellular carcinoma- IPI:IPI00182422.1 GP:AF286340_1 associated antigen 137 (HCA137) V.IAIDIDPVKIALAR.N 2 2.393 0.132 O (92%) mRNA, complete cds. Homo sapiens enhancer of polycomb 2 (EPC2) mRNA, complete cds; GP:AF286905_1 N.TSQGFVSKTLDSASAQ.F 2 3.057 0.195 A transcriptional repressor from the polycomb group. GP:AF287261_1 Homo sapiens PR/SET domain- T.DGENVFTGQSKIYSYMSPNK.C 2 2.232 0.189 O IPI:IPI00006919.2
Supplementary Table 2 30 containing protein 07 (SET07) mRNA, (94%) complete cds. Homo sapiens calcium channel gamma GP:AF288388_1 E.AGGGVTVTVTGPPAPPA.P 2 2.434 0.110 G subunit 8 (CACNG8) mRNA, partial cds. Homo sapiens C1orf26 mRNA, complete IPI:IPI00097540.1 GP:AF288392_1 D.FKPKDIKLTNAGSKLDHGIKSL.S 2 2.895 0.109 O cds. (96%) Homo sapiens C1orf25 mRNA, complete GP:AF288399_1 V.VRVLRGPTSADETAKK.I 2 2.300 0.212 P cds. Homo sapiens putative T7-like mitochondrial DNA helicase (C10orf2) mRNA, complete cds; nuclear gene for IPI:IPI00102660.1 GP:AF292004_1 K.GHRKGELTVFTGPTGSGKT.T 1 1.809 0.105 G mitochondrial product; alternatively (97%) spliced; Twinkle; Twinky; alternatively spliced. Homo sapiens nonselective sodium potassium/proton exchanger (NHE7) mRNA, complete cds; ion transporter; (Na+,K+)/H+ exchanger; similar to Homo GP:AF298591_1 I.FRLWYSFDHN.Y 1 2.413 0.168 A sapiens sequences presented in GenBank Accession Numbers AA279477, AA648924, AL022165 and AL050307. Homo sapiens X-linked ectodysplasin-A2 IPI:IPI00029116.1 GP:AF298812_1 receptor (XEDAR) mRNA, complete cds; A.ETLGGNTVESTGDRLELNVPFEVP.S 2 2.455 0.148 P (93%) member of the TNFR superfamily. Homo sapiens apoptosis inhibitor GP:AF300871_1 K.YIKDYMKSINEK.L 2 2.485 0.131 A (FKSG2) mRNA, complete cds. Homo sapiens immunoglobulin kappa IPI:IPI00030205.1 GP:AF303897_1 -.SQIVSSSYLAWYQQKPGQ.A 2 3.972 0.124 G chain gene, partial cds. (95%) Homo sapiens hematopoietic zinc finger protein (HZF) mRNA, complete cds; GP:AF304052_1 H.YKGNRHAR.R 1 2.019 0.129 P similar to Mus musculus hematopoietic zinc finger protein. Homo sapiens tankyrase-related protein IPI:IPI00019270.1 GP:AF305081_1 S.GTILIDLSPDDKEFQSV.E 1 2.279 0.080 G mRNA, partial cds. (91%) Homo sapiens PRO1355 mRNA, GP:AF305823_1 V.QEAEEGSCFDSFLAMWDVSDIR.D 2 2.324 0.149 P complete cds. Homo sapiens clone TF3.19 immunoglobulin light chain variable IPI:IPI00003486.1 GP:AF306363_1 region mRNA, partial cds; TF3.19 VL; A.SQSVSSTFLAWYQQKPGQAPR.L 2 2.287 0.110 G (94%) thyroid peroxidase autoantibody; binds to TPO non-immunodominant region. Tetraodon fluviatilis STAT1 mRNA, GP:AF307105_1 complete cds; similar to Homo sapiens A.RALELLKNILSSSLVVE.R 2 2.487 0.103 O STAT1. Homo sapiens B aggressive lymphoma IPI:IPI00027803.1 GP:AF307338_1 F.PLNLCTKTIVETIRV.S 2 2.701 0.227 O, P long isoform (BAL) mRNA, complete cds. (95%) Homo sapiens clone ST1R_G2 GP:AF308552_1 immunoglobulin heavy chain mRNA, G.GIIPISGATNYAQKFQGR.V 2 2.352 0.129 G partial cds. Homo sapiens SOX6 mRNA, complete A.AQQGFLFPPGITYKPGDNYPVQFIPSTMA GP:AF309034_1 3 3.922 0.219 O cds; transcription factor. AAAASGLSP.L Homo sapiens oxidation protection IPI:IPI00164898.1 GP:AF309387_1 protein (OXR1) mRNA, complete cds; K.KIEESETIEDSSNQA.A 1 1.871 0.093 G (98%) oxidation resistance. Homo sapiens IRS-1 PH domain binding IPI:IPI00103390.1 GP:AF310250_1 A.KTFITKANASAI.P 1 2.026 0.080 A protein PHIP mRNA, complete cds. (93%) Homo sapiens E3 ubiquitin ligase IPI:IPI00216373.1 GP:AF310676_1 P.RDLSNINCEELGPLPPGWEI.R 2 2.748 0.252 G SMURF2 mRNA, complete cds. (98%) Homo sapiens myosin binding subunit 85 mRNA, complete cds; protein phosphatase 1 subunit protein; contains L.QAGYDPELRDGDGWTPLHAAAHWGVED GP:AF312028_1 N-terminal ankyrin repeats and C- 2 2.475 0.115 A A.C terminal leucine zipper; phosphorylation of a conserved central motif regulates associated PP1 delta activity; Homo sapiens acetylcholinesterase (ACHE) gene, partial cds; ASR2 (ASR2) gene, complete cds, alternatively spliced; IPI:IPI00000292.1 GP:AF312032_2 thyroid receptor interacting protein 6 W.QEVSAAFDPNSFYNLCLTSL.S 2 2.545 0.120 G (92%) (TRIP6) gene, complete cds; cation- chloride cotransporter (CIP1) gene, complete cds, alternative Homo sapiens FGF homologous factor GP:AF312678_1 V.VLDDISPGKESLGPDS.S 2 2.491 0.147 P receptor (FHFR) mRNA, complete cds. GP:AF313800_1 Mus musculus K20D4 (K20D4) mRNA, G.TTPPYCCVDLYSLRTGEMVK.S 2 2.430 0.139 G IPI:IPI00025145.1
Supplementary Table 2 31 complete cds; contains WD40 domains (96%) and transmembrane regions; similar to Homo sapiens unnamed proteins BAB15156 and BAB14380; similar to Drosophila melanogaster CG1905 gene product. Homo sapiens anion IPI:IPI00168175.1 GP:AF314958_1 transporter/exchanger-9 (SLC26A9) L.LGGLSGGSIQVPQ.G 2 2.486 0.133 A (98%) mRNA, complete cds. Homo sapiens coactivator activator mRNA, complete cds, alternatively GP:AF315632_1 G.SSLASYGNQPSSYGAQAASSY.G 2 2.983 0.088 P spliced; CoAA; TRBP-interacting; alternatively spliced. Homo sapiens Galbeta1-3GalNAc 3'- IPI:IPI00183885.1 GP:AF316113_1 K.GYRPQGGGTQLPFHILCHHMR.F 2 2.290 0.109 O sulfotransferase mRNA, complete cds. (94%) Homo sapiens asporin precursor (ASPN) mRNA, complete cds; preproprotein; type IPI:IPI00153057.1 GP:AF316824_1 V.TVFHIRIAEAKLTSVPK.G 2 2.424 0.115 G I extracellular matrix leucine-rich repeat (94%) protein. Homo sapiens fibronectin type 3 and SPRY domain-containing protein 1 IPI:IPI00177444.1 GP:AF316829_1 (FSD1) mRNA, complete cds; FSD1; L.KFLPVPSAPVIDLAESLV.A 2 2.608 0.102 O (93%) sp1a/ryanodine domain; contains a coiled-coil motif. Homo sapiens zinc transporter 1 (ZNT1) N.TLVANTSNSNGLKLDPADPENPRSGDTVE GP:AF323590_1 3 3.756 0.138 P gene, complete cds. VQV.N Homo sapiens OSBP-related protein 6 IPI:IPI00167804.1 GP:AF323728_1 mRNA, complete cds; similar to D.KASETDDPYERMVLVAAFAV.S 2 2.507 0.110 O (93%) oxysterol-binding protein; ORP6. Homo sapiens OSBP-related protein 8 K.SDKENDQEHDESDNEVMGKSEESDTDTS IPI:IPI00068509.2 GP:AF323730_1 mRNA, partial cds; similar to oxysterol- 3 3.553 0.156 P ERQD.D (93%) binding protein; ORP8. Homo sapiens Kruppel-like zinc finger protein GLIS2 mRNA, complete cds; GP:AF325914_1 P.LPKQLVCRWAKCNQLFELL.Q 2 2.504 0.103 O transcription factor; related to Gli subfamily. Homo sapiens ciliary dynein heavy chain IPI:IPI00178102.1 GP:AF327442_1 A.TFAYTKYERINWVRDWPG.Q 2 2.638 0.108 P 7 (DNAH7) mRNA, complete cds. (96%) Homo sapiens transmembrane protein IPI:IPI00167048.1 GP:AF327923_1 induced by tumor necrosis factor alpha G.FPFLLLFLGNF.F 2 2.481 0.128 G (98%) (TMPIT) mRNA, complete cds. Homo sapiens ovary-specific acidic GP:AF329088_1 S.SAGDDLQEEASVGSEAASAQRA.N 2 2.536 0.105 P protein mRNA, complete cds; OSAP. Homo sapiens complement-c1q tumor F.AQVGDRSIMQSQSLMLELREQDQVWVRL IPI:IPI00075013.1 GP:AF329840_1 necrosis factor-related protein (CTRP1) 3 3.729 0.106 A YK.G (91%) mRNA, complete cds. Homo sapiens LIM domain only 7 IPI:IPI00182721.1 GP:AF330045_1 T.ILIKAVTEKNFETKDFRA.S 2 2.457 0.178 A (LMO7) mRNA, complete cds. (97%) Homo sapiens putative protein WHSC1L1l (WHSC1L1) mRNA, IPI:IPI00185215.1 GP:AF332469_1 A.FDNNSDIAEDGGQT.P 2 2.644 0.174 A complete cds, alternatively spliced; (97%) alternatively spliced. Homo sapiens zonadhesin variant 1 (ZAN) mRNA, complete cds; unique D4 domain; putative sperm-egg adhesion IPI:IPI00220097.1 GP:AF332975_1 molecule; binds in species-specific L.LLVGAALFR.K 1 1.898 0.138 P (92%) manner to oocyte zona pellucida and may mediate species-specific adhesion of gametes; comprised of MAM, muci Homo sapiens FKSG48 (FKSG48) mRNA, complete cds; similar to other IPI:IPI00176892.1 GP:AF336875_1 P.PFPPFYSTKPPLSPWPISNEPLGTPPR.R 2 2.233 0.128 A members in this gene family FKSG48 to (97%) FKSG70. Homo sapiens clone HSK-76 IPI:IPI00003457.1 GP:AF338918_1 immunoglobulin kappa light chain Q.FNTYPYTFGQGTK.L 2 2.415 0.107 G (91%) variable region mRNA, partial cds. Homo sapiens mitochondrion, complete genome; TAA stop codon is completed GP:AF346970_13 L.LSATPYIGTDLVQWIWGGYSVDS.P 2 2.536 0.128 G by the addition of 3' A residues to the mRNA. Rattus norvegicus KIAA1454-like protein GP:AF347027_1 mRNA, partial cds; similar to Homo K.DRVPAETVGMVTET.T 1 1.949 0.086 G sapiens KIAA1454. Caenorhabditis elegans Toll-like receptor TOL-1 mRNA, complete cds; similar to GP:AF348166_1 V.SLSNNGITIMNADQIPNSLESLDVSNNR.L 2 2.753 0.089 P Drosophila Toll and 18-wheeler and Homo sapiens TLR (Toll-like receptor) Supplementary Table 2 32 proteins. Homo sapiens clone 26-23c GP:AF348835_1 immunoglobulin heavy chain variable A.EVQLVQSGAEVKKPGESLTI.S 2 2.460 0.220 O region mRNA, partial cds; VH 5-51. Homo sapiens channel kinase 2 (CHAK2) mRNA, complete cds; ChaK2; IPI:IPI00165024.1 GP:AF350881_1 Y.SDQNASSSKESASVKEYDLERGHD.E 2 2.445 0.100 O protein kinase/ion channel; bifunctional; (96%) kidney alpha-kinase. Homo sapiens proliferation potential- related protein mRNA, complete cds; GP:AF352051_1 Y.NNDNTAPAEDVIIMIQVPQ.S 2 2.845 0.118 G similar to mouse proliferation potential- related protein. Homo sapiens ATP-binding cassette IPI:IPI00186714.1 GP:AF352582_1 transporter MRP8 mRNA, complete cds; L.FVAFGISSTPYSFKVMA.V 2 2.510 0.120 O (96%) ABC transporter. Homo sapiens iris ring finger protein IPI:IPI00220776.1 GP:AF353673_1 K.KLSFIEALIQQ.Y 2 2.570 0.082 A mRNA, complete cds; IRF. (95%) Homo sapiens BTBD2 protein mRNA, GP:AF355797_1 complete cds; BTB-containing Kelch-like S.ANAAATPAPGNA.A 1 2.131 0.227 A protein. Homo sapiens sorbin and SH3 domain GP:AF356525_1 containing 1 mRNA, complete cds, D.HLALSPRASPSLSLSLPHL.S 1 2.217 0.160 O alternatively spliced; SORBS. Homo sapiens a disintegrin-like and metalloprotease with thrombospondin type 1 motif 14 precursor (ADAMTS14) IPI:IPI00219596.1 GP:AF358666_1 I.NYSMDEQCRFDFGSGYQ.T 2 2.473 0.112 A mRNA, complete cds; extracellular (95%) protease; low level expression in the brain, lungs and liver in adults; MD. Homo sapiens mucin 16 (MUC16) IPI:IPI00178161.1 GP:AF361486_1 mRNA, partial cds; ovarian cancer S.TTSTPGTPTVYL.G 1 2.289 0.236 O (92%) antigen CA125. Homo sapiens gamma cysteine string GP:AF368277_1 protein mRNA, partial cds; gamma-CSP; K.IYDQHGSLGIY.L 2 2.425 0.103 G exclusively expressed in testis. Homo sapiens inositol polyphosphate 4- phosphatase type I alpha 3 mRNA, IPI:IPI00044388.1 GP:AF368319_1 Q.EVINVESLVRLNSYFE.Q 2 3.335 0.201 O complete cds, alternatively spliced; (94%) alternatively spliced. Homo sapiens putative pre-mRNA splicing regulator female-lethal(2D) IPI:IPI00014150.1 GP:AF374416_1 mRNA, complete cds; FL(2)D; similar to A.GYESVDSPTGSENSL.T 2 2.423 0.127 O (91%) Homo sapiens WTAP protein encoded by GenBank Accession Number AJ276706. Homo sapiens clone MEI GP:AF376954_1 immunoglobulin heavy chain variable -.ELQLVESGGGFVQPGGSLR.L 2 2.453 0.106 G region gene, partial cds. Homo sapiens SECIS binding protein 2 IPI:IPI00077841.1 GP:AF380995_1 Y.QKDPVKAK.T 1 1.812 0.101 A (SBP2) mRNA, complete cds. (92%) Homo sapiens immunoglobulin heavy GP:AF381165_1 chain variable region 32A-5-H, mRNA, M.NSLRPEDTAVYYCVRPRVRAVV.M 2 2.463 0.227 O partial cds. Homo sapiens F-box protein FBX30 mRNA, partial cds; similar to budding IPI:IPI00075075.1 GP:AF383178_1 yeast CDC4; start codon not defined; L.KDNILVSGNADS.T 2 2.474 0.265 G (98%) contains an F-box motif and WD40 repeats. Homo sapiens carboxypeptidase A5 IPI:IPI00103586.1 GP:AF384667_1 F.SFILAAALGQMNFTGDQVLRVL.A 2 2.473 0.144 A mRNA, complete cds; CPA5. (97%) Homo sapiens PAS-kinase (PASK) IPI:IPI00185292.1 GP:AF387103_1 D.RWSSYCLSSLAAQNICTSKL.H 2 2.619 0.091 G mRNA, complete cds; protein kinase. (97%) Homo sapiens TCR beta chain GP:AF387747_1 Vbeta13S3-PGLVRETQYF-Jbeta2.5 Y.YSASEGTTDKGEVPNGYYVSRLNK.R 2 2.240 0.205 G mRNA, partial cds. Homo sapiens histone deacetylase 10 IPI:IPI00216341.1 GP:AF393962_1 isoform b mRNA, complete cds; F.QPDLVLVALGPGHGLQGPHAALLAAM.L 2 2.565 0.189 G (91%) HDAC10b. Homo sapiens clone EIII48bpVNTR40 GP:AF395249_1 dopamine receptor D4 (DRD4) gene, A.PCLPRGPCGPDCAPAAPSLPPD.P 2 2.427 0.155 G partial cds. Homo sapiens TCR beta chain Vbeta GP:AF395522_1 13S3-LLQGYTF-Jbeta1.2 mRNA, partial S.GTRLTVVQDLFKVFPPEVAVFEPP.E 2 3.080 0.125 O cds. Homo sapiens TCR beta chain Vbeta GP:AF395528_1 13S3-PPPGQGAHGYTF-Jbeta 1.2 C.VAFSLPWASPVNAGVTQTPKFQV.L 2 2.449 0.131 O mRNA, partial cds.
Supplementary Table 2 33 Homo sapiens NAC1 protein mRNA, V.AAGAGQPAGGVAAAGGVVSGPSTSERTS GP:AF395817_1 complete cds; transcriptional repressor; 2 2.410 0.140 A .P contains POZ domain. Homo sapiens clone OR7G1 olfactory GP:AF399538_1 receptor gene, partial cds; contains C.KNVEIPLFFCEVVQVIK.L 2 2.435 0.138 A transmembrane regions 2-7. Homo sapiens clone OR1F2 olfactory GP:AF399558_1 receptor gene, partial cds; contains L.MARLSFCADNTIPHIFCDVT.P 2 2.466 0.168 A transmembrane regions 2-7. Homo sapiens clone OR10G3 olfactory IPI:IPI00185076.1 GP:AF399566_1 receptor gene, partial cds; contains S.TCGAHVTVVTVYYVPC.A 2 3.117 0.139 G (92%) transmembrane regions 2-7. Homo sapiens beta-glucan receptor isoform F (BGR) mRNA, complete cds, GP:AF400600_1 T.QLHFDSQSNTRIAVVSEKGI.Y 2 2.639 0.117 O alternatively spliced; C-type lectin BGRF; alternatively spliced. Homo sapiens cysteine and tyrosine-rich GP:AF401639_1 P.TPQGPAQRSPPPPYPGNA.R 2 2.518 0.150 G protein 1 (CYYR1) mRNA, complete cds. Homo sapiens differentiation-related DIF14 long form (DIF14) mRNA, IPI:IPI00184329.1 GP:AF402318_1 I.SLFLSTFTLAVSAGAVSLLPFSI.I 2 2.481 0.181 A complete cds, alternatively spliced; (92%) membrane receptor; alternatively spliced. Homo sapiens MHC class I antigen IPI:IPI00218315.1 GP:AF405691_1 heavy chain (HLA-CW) mRNA, HLA- D.ESLIACKPETAACVGLR.C 2 2.366 0.212 A, O (92%) CW*04null allele, complete cds. Homo sapiens putative gap junction protein pannexin 3 (PANX3) mRNA, IPI:IPI00045156.1 GP:AF406650_1 complete cds; contains four putative A.LALLMYLPVLLWQY.A 2 2.403 0.107 A (91%) transmembrane domains; similar to innexin gap junction gene family. Homo sapiens clone CbG8h anti- pneumococcal capsular polysaccharide G.GGVVQPGGALRLSCAASGFTFSTSGMHW GP:AF408731_1 2 2.438 0.100 A immunoglobulin heavy chain variable .V region (IgA) mRNA, partial cds; Vh3-30. Homo sapiens clone DMF4 anti- pneumococcal capsular polysaccharide GP:AF408738_1 K.KPGASVKVSCKASGYIFDNYYIHWVR.Q 2 2.234 0.162 P immunoglobulin heavy chain variable region (IgA) mRNA, partial cds; Vh1-46. Homo sapiens importin 9 mRNA, IPI:IPI00166326.1 GP:AF410465_1 complete cds; importin beta-like nuclear A.AAAAGAASGLPGPVAQGLKEAL.V 2 2.534 0.121 P (96%) import receptor. Homo sapiens isolate NSB11-5-K1-A12 IPI:IPI00003457.1 GP:AF410548_1 immunoglobulin kappa chain variable Q.GISSALAWYQQKPGKAPKLLIYD.A 2 3.630 0.206 G (93%) region gene, partial cds. Homo sapiens G protein-coupled GP:AF411107_1 C.AWGQSLAFSGAALGCSWLGY.S 2 2.894 0.211 G receptor (GPR78) mRNA, complete cds. Homo sapiens type II phosphatidylinositol 4-kinase beta GP:AF411320_1 D.DPEFADIML.R 1 2.020 0.102 P isoform mRNA, complete cds; PI4KIIbeta. Homo sapiens C6ORF34B mRNA, partial cds, alternatively spliced; chromosome 6 GP:AF411610_1 N.QEQLLTLASILREDGK.V 2 2.347 0.116 G open reading frame 34; alternatively spliced. Homo sapiens C-type lectin-like receptor GP:AF411850_1 L.MTISTEAEQNFIIQ.F 2 2.603 0.107 O CLEC-6 mRNA, complete cds. Homo sapiens NOL1R mRNA, complete IPI:IPI00101659.1 GP:AF420249_1 P.HLAKVLVYELLLGKGFR.G 2 2.563 0.127 G cds; member of NOL1/NOP2/sun family. (96%) Homo sapiens testis-specific inhibitor of apoptosis (BIRC8) mRNA, complete cds; GP:AF420440_1 G.HLVTCKQCAEAVDR.C 1 1.959 0.151 P similar to the third BIR domain and zinc finger o. Homo sapiens MUS81 endonuclease IPI:IPI00102384.1 GP:AF425646_1 P.ASLLAAYDACATPKEQETLLS.T 2 3.032 0.129 P (MUS81) mRNA, complete cds. (95%) Homo sapiens T-cell receptor beta-chain GP:AF428127_1 (TCRVb7.1-Jb1.2) mRNA, partial cds; T- L.YLCASSQFWTGRNGGYTFGSGTR.L 2 2.443 0.170 P cell receptor. Homo sapiens densin-180 mRNA, IPI:IPI00102378.1 GP:AF434715_1 A.GKVKDLSCQAPWERGQRGIT.L 2 2.633 0.088 O, P complete cds. (95%) Homo sapiens Ras-induced senescence GP:AF438313_1 1 (RIS1) mRNA, complete cds; candidate A.AAAAAAAAAAVTSGVATK.- 2 2.221 0.116 A tumor suppressor protein. Xenopus laevis Os4 mRNA, complete cds; induces partial secondary dorsal GP:AF441288_1 E.LLSLIPIFEEFSYSEDIYTSLGQLK.A 3 3.796 0.129 A axis in Xenopus embryos; similar to Homo sapiens Os4.
Supplementary Table 2 34 Homo sapiens isolate PC-1 GP:AF442750_1 immunoglobulin heavy chain variable Y.FCARVVVPDHGGNSGYVDNWGQGTL.V 2 2.639 0.103 P region mRNA, partial cds. Homo sapiens isolate WD-9 GP:AF442767_1 immunoglobulin kappa light chain K.VLIYGASNLQSGVPSR.F 2 2.444 0.225 G variable region mRNA, partial cds. Homo sapiens mRNA for dynein heavy IPI:IPI00176312.1 GP:AJ000522_1 L.SEMDEFKNLDSDIEGSAKR.W 2 2.372 0.100 A chain. (93%) Homo sapiens mRNA for immunoglobulin GP:AJ001408_1 heavy chain variable region to JH X.EVQLVDSGGGLVQPGGSLR.L 2 2.346 0.119 P segment, EJ-1F. IPI:IPI00160131.1 GP:AJ001714_1 Homo sapiens mRNA for myosin-IXA. S.WHNIDYIDNTCYINLISK.K 2 2.347 0.102 A (97%) Homo sapiens mRNA for protein encoded by Saccharomyces cerevisiae S.LLPGQSNQAPGVGDCLRQQLGSRLAWTL IPI:IPI00221174.1 GP:AJ003061_1 3 3.962 0.168 A SPC98 homologue; most expressed SANQPSSQA.T (95%) alternative spliced form. GP:AJ010482_1 Homo sapiens mRNA for myopodin. Y.QRKEEESVRTQ.S 1 2.089 0.086 O Homo sapiens ammecr1 gene, exon 1 GP:AJ012221_1 and joined CDS (alternative transcripts); L.SPPQGCGGGGGGIALSPPPSC.G 2 2.539 0.139 P alternative transcript. Homo sapiens mRNA for transcription GP:AJ130894_1 G.SEQGSTSQEQALSAQQAA.V 2 2.871 0.138 P factor. Homo sapiens mRNA for birch pollen allergen specific immunoglobulin gamma IPI:IPI00018563.3 GP:AJ131060_1 R.YSPSFEGQVTISADK.S 2 2.308 0.254 G chain (BAB5-H), complete V-D-J region; (94%) complete V-D-J region. Homo sapiens mRNA for immunoglobulin GP:AJ132426_1 light chain variable region (partial), Fab K.LLIYDVSNRPSGVSNR.F 2 2.226 0.138 G fragment, clone PSG46. Homo sapiens mRNA for immunoglobulin GP:AJ132564_1 K.NSLSLQMDSLR.A 2 2.292 0.217 G heavy chain, partial. Homo sapiens mRNA for receptor for Advanced Glycation End Product, GP:AJ133822_1 G.NSSPGPGDPGRPGDSRPAHWGHLVAK.A 2 2.355 0.133 P secreted isoform (RAGEsec gene); secreted isoform. GP:AJ222551_1 Homo sapiens mRNA for IgA, clone AF6. F.GTVVSGDWGQGTLVTVSSASPTSPK.V 2 2.387 0.179 P R.GKSESSRGRRVYYDEGVASSDDDSSGDE GP:AJ224868_1 Homo sapiens GNAS1 gene. 3 3.569 0.092 G SD.D Homo sapiens DNA for Ig heavy chain GP:AJ225721_1 variable region, isolate cell G2 23; VH 3 L.LRVPTISSDGSKKD.Y 1 2.056 0.134 P family gene, non-functional. Homo sapiens DNA for Ig heavy chain GP:AJ225742_1 variable region, isolate cell G2 65; VH 4 R.VTISXDTSK.N 1 2.209 1.000 G family gene. Homo sapiens DNA for Ig heavy chain GP:AJ225761_1 variable region, isolate cell G2 95; VH 1 T.ASMEVNKCQQSPGPPRAQSER.V 2 2.224 0.114 O family gene, non-functional, deletion i. Homo sapiens mRNA for hypothetical IPI:IPI00000194.2 GP:AJ237839_1 E.SDAEEDLYDAAAASAMASSSAPSVYSV.Q 2 2.407 0.260 A protein; C21orf5. (94%) Homo sapiens mRNA for IGHV gene for immunoglobulin heavy chain variable GP:AJ238037_1 S.DGTTTHYADSVK.G 2 2.356 0.182 P region, IgM multiple myeloma patient CLE. Homo sapiens mRNA for huntingtin IPI:IPI00171041.1 GP:AJ238403_1 R.LQSVVVVPKNSTLPMEETSPCSSR.S 2 2.245 0.179 A interacting protein 1. (95%) Homo sapiens mRNA for immunoglobulin GP:AJ239335_1 L.NSVTAADAAVYYCARSP.N 1 2.050 0.181 A heavy chain variable region, ID 42; ID 42. Homo sapiens mRNA for immunoglobulin GP:AJ239353_1 L.VESGGGSVQ.P 1 2.209 0.084 O heavy chain variable region, ID 66; ID 66. Homo sapiens mRNA for immunoglobulin GP:AJ239374_1 R.QAPGKGLEWIGR.I 2 2.338 1.000 G heavy chain variable region, ID 6; ID 6. GP:AJ239391_1 Homo sapiens IGHV gene, ID 58; ID 58. S.LKSRVTILVDTSENQF.F 2 2.436 0.110 G Homo sapiens mRNA for E-MAP- GP:AJ242502_1 115/105 (MAP gene); isotype of E-MAP- E.RREEREKQLA.A 2 2.681 0.103 O 115; E-MAP-115-105. Homo sapiens mRNA for IPI:IPI00181420.1 GP:AJ242586_1 T.YQLVYFLDK.I 1 1.803 0.088 A aminopeptidase B (RNPEP gene). (96%) Homo sapiens partial mRNA for putative protein p241 which interacts with GP:AJ242976_1 E.RSSRSPSR.E 2 2.449 0.109 O transcription factor Sp1; interacts in vitro with transcription factor Sp1. Homo sapiens titin zinc-finger anchoring IPI:IPI00216729.1 GP:AJ243489_1 A.TSQIGFEAPPLQGQAAAPASG.S 1 2.118 0.124 O protein, 60kDa isoform; 60kDa isoform. (99%) IPI:IPI00221393.1 GP:AJ245620_1 Homo sapiens CTL1 gene. W.ISEFILACQQ.M 1 2.016 0.137 A (93%) Supplementary Table 2 35 GP:AJ245746_1 Homo sapiens mRNA for NuBI-1 protein. G.PDSGGRVKGVTIVKPIVYGNVA.R 2 2.602 0.259 P Homo sapiens mRNA for putative acid- I.ECADHTLDSLGGGPEGPCFCPTPCNLTRY GP:AJ271643_1 2 2.391 0.102 A sensing ion channel (ASIC4 gene). GK.E Homo sapiens mRNA for vanilloid IPI:IPI00182026.1 GP:AJ272063_1 L.EELTNKKGMMPLALAAGTG.K 2 2.708 0.084 O receptor 1 (VR1 gene). (99%) Homo sapiens partial IGVH3 gene for GP:AJ275434_1 immunoglobulin heavy chain V region, V.SSHYMSWVRQAPGKGLEWVSV.M 2 2.479 0.116 G case 2, cell B 16. Homo sapiens partial IGVH3 gene for IPI:IPI00178741.1 GP:AJ275437_1 immunoglobulin heavy chain V region, L.DRYYYGSGSSYGMDVW.- 2 2.415 0.297 A (98%) case 2, cell B 25. Homo sapiens mRNA for putative GP:AJ276095_1 G.NRTPSPNSNEQQKSLNGGDEA.P 2 2.474 0.258 O recombinase (def-6 gene). Homo sapiens mRNA for HEF like IPI:IPI00220359.1 GP:AJ276678_1 A.SIVIANGRL.L 1 2.148 0.168 A, O Protein (HEFL gene). (93%) Homo sapiens mRNA for nuclear RNA GP:AJ277527_1 S.ALFTLVPTAFSSSVPA.F 1 2.274 0.083 G export factor 3 (NXF3 gene). GP:AJ277841_1 Homo sapiens mRNA for ELG protein. R.IGNKLPPEKFAD.V 1 1.890 0.162 G Homo sapiens partial TTN gene for titin; IPI:IPI00142883.1 GP:AJ277892_2 Y.APIGTAAYFQ.C 1 2.065 0.123 O short Titin Novex-3 Isoform. (95%) Homo sapiens VL1 gene for anti-17beta- GP:AJ278778_1 estradiol immunoglobulin light chain N.IGSKSVNWYQQLPGTAPR.L 2 2.310 0.356 G variable region, clone B11. Homo sapiens mRNA for putative GP:AJ291679_1 metallopeptidase (family M19); family I.RAVIGSEFIGIGGNYDGTGRF.P 2 2.408 0.110 G M19. Coccidioides immitis partial tcrP gene for GP:AJ291968_1 human T-cell reactive protein, strain N.IIDAITNLKARGTEFIKVPETY.Y 2 2.500 0.117 A RMSCC 757, exons 1-3. Homo sapiens partial GGVK3 gene for GP:AJ292937_1 immunoglobulin kappa light chain, Y.GTSARATGIPDR.F 2 2.476 0.168 G variable region exon 1. Arabidopsis thaliana mRNA for splicing GP:AJ293796_1 factor SC35; orthoglogue of human R.SPALQKASPSKDMSPER.R 2 2.428 0.172 P SC35. Homo sapiens mRNA for putative IPI:IPI00007110.1 GP:AJ295148_1 G.LALSLGVGLSF.S 1 2.005 0.127 G sialoglycoprotease type 2. (95%) Homo sapiens partial MUC5AC gene for IPI:IPI00220367.1 GP:AJ298318_1 S.APTTNTTSAPTTSTTSAPI.T 2 2.515 0.116 P mucin 5, clone A. (95%) Homo sapiens partial IGVH6-4.1b gene for immunoglobulin heavy chain variable GP:AJ298460_1 E.LKKPGASVRVSCKASGYTFTT.Y 2 3.199 0.167 P region, patient 1, small EBER+ cell isolate 117. Homo sapiens mRNA for putative white GP:AJ300465_1 family ATP-binding cassette transporter S.AKLFEMFDKLYI.L 1 2.474 0.154 P (ABCG4 gene). Homo sapiens mRNA for SSF1/P2Y11 GP:AJ300588_1 N.LNTIKRCLLIDYNPDSQELDFRHYSIKV.V 2 2.635 0.221 A chimeric protein. Homo sapiens partial BV10S1J2.1 gene GP:AJ301505_1 for T-cell receptor beta chain VJ region, L.YFCARGETGVSYEQYFGPGTRL.T 2 2.543 0.312 A patient A6, 296 BP. Homo sapiens 6M1-3*02 gene for IPI:IPI00216102.1 GP:AJ302552_1 olfactory receptor, cell line BM28.7 P.LILILTSYGAIVQAVLR.M 2 2.243 0.140 G (95%) olfactory receptor. Homo sapiens mRNA for RhoGAP IPI:IPI00064767.1 GP:AJ306731_1 S.FHTGNDSDSGTLERKR.P 1 1.848 0.100 P protein (RICH1 gene). (98%) Homo sapiens partial mRNA for anti- IPI:IPI00003489.1 GP:AJ307664_1 DNA immunoglobulin kappa chain R.FTGSGSGTDFTLTISR.L 2 2.338 0.241 G (94%) variable region (IGKLV-A271 gene). Homo sapiens mRNA for putative zinc A.PKAGYSQGATQYTQAQQTRQVTAIKPATP GP:AJ314790_1 2 2.411 0.108 O finger protein (ZFR gene). SPAT.T Homo sapiens partial mRNA for immunoglobulin heavy chain variable GP:AJ316217_1 G.TKVIVSSASTK.G 2 2.426 0.270 G region (IGHV4 gene), isolate Patient vdM. Homo sapiens mRNA for SRPK1a IPI:IPI00178339.1 GP:AJ318054_1 protein kinase (SRPK1 gene); L.SVNEQYIRRLAAEATE.W 2 2.514 0.157 P (91%) alternative. Homo sapiens partial IGVKLVFK431 IPI:IPI00161229.1 GP:AJ347552_1 gene for immunoglobulin kappa chain S.GVPSKFSGSR.S 1 1.908 0.084 G (94%) variable region, isolate case2-cell86. Homo sapiens partial IGVKA20 gene for IPI:IPI00007852.1 GP:AJ347586_1 immunoglobulin kappa chain variable R.ASQGISDYLAWFQQKPGK.V 2 2.246 0.126 G (92%) region, isolate case3-cell3. Homo sapiens IGVH gene for GP:AJ389914_1 R.VXMTTDTSTSTAYMELR.S 2 2.300 0.182 G immunoglobulin heavy chain variable
Supplementary Table 2 36 region (VH1 family), cell 132. Homo sapiens partial mRNA for thyroid peroxidase-specific immunoglobulin IPI:IPI00154742.1 GP:AJ399869_1 L.PGTAPKLLIYDNTNRPSGVPD.R 2 2.672 0.310 P lambda chain variable region (IGLV (96%) gene), clone T13. Homo sapiens partial mRNA for thyroid peroxidase-specific immunoglobulin GP:AJ399872_1 -.ETTLTQSPATLSLSPGER.A 2 2.442 0.198 O kappa chain variable egion (IGKV gene), clone T2. Homo sapiens mRNA for IPI:IPI00184019.1 GP:AJ400841_1 immunoglobulin-like cell surface receptor G.IVYASLALSSSTSPRA.P 1 2.055 0.161 A (99%) FDF03. Homo sapiens mRNA for rab interacting GP:AJ404317_1 A.GAGAPGNPEDPAEAAQQLGRP.S 2 2.784 0.143 G lysosomal protein (RILP gene). Homo sapiens mRNA for hypothetical GP:AJ404607_1 S.RPRSRPSSSSRAIR.S 2 2.344 0.235 O protein, clone Jua-XI35consA; ORF1. Homo sapiens partial VH1-24 gene for rearranged immunoglobulin heavy chain GP:AJ406643_1 T.AYMELSSLRSEDTAVYYCATVTG.V 2 3.115 0.105 P variable region, isolate case4-PTGC1- 176. Homo sapiens partial VK L12 gene for IPI:IPI00003457.1 GP:AJ406736_1 rearranged immunoglobulin kappa chain R.ASQTISNWLAWYQQK.P 2 2.380 0.170 G (97%) variable region, isolate case5-PTGC1-29. Homo sapiens partial VK L12 gene for rearranged immunoglobulin kappa chain IPI:IPI00003457.1 GP:AJ406753_1 R.ASQSISGWLAWYQQK.P 2 2.633 0.232 G variable region, isolate case5-PTGC2- (98%) 120. Homo sapiens partial IGKV gene for IPI:IPI00030205.1 GP:AJ408400_1 immunoglobulin kappa chain variable G.QAPRLLIYGASSRATGVPDRF.S 2 2.512 0.180 G (96%) region, clone 5. Homo sapiens partial IGKL gene for GP:AJ408522_1 immunoglobulin lambda chain variable A.LTQPPSASGSPGQSVTIFCTGT.S 2 2.459 0.157 O region, clone 127. Homo sapiens partial IGKV gene for GP:AJ408549_1 immunoglobulin kappa chain variable S.SSYLAWYQQKPGQTPRLLIYGASNRA.T 2 2.508 0.100 A region, clone 154. Homo sapiens partial IGVK gene for immunoglobulin kappa light chain GP:AJ409190_1 R.ASQSVRTLAWYQQKPGQAPR.F 2 2.402 0.147 G variable region, isolate case 1, follicular lymphoma, VkA27, cell BC23. Homo sapiens partial VH3-23 gene for GP:AJ410899_1 immunoglobulin heavy chain variable L.SIDTSNNAFSLNLSSVTAADT.A 2 2.566 0.135 A region, from follicular lymphoma: FL-3H. Homo sapiens partial mRNA for Sec5 IPI:IPI00215805.1 GP:AJ414403_1 L.VKLTRGALLPLSIR.D 2 2.266 0.101 G protein (SEC5 gene). (94%) Homo sapiens partial IGVKL12 gene for IPI:IPI00003457.1 GP:AJ414849_1 immunoglobulin kappa chain variable K.AXSLESGVPSR.F 2 2.494 0.174 G (97%) region, donor BJ, cell8. Homo sapiens partial IGVL1c gene for GP:AJ415087_1 immunoglobulin lambda chain variable K.VLIYSNDQRPSGVPDR.F 2 2.248 0.155 G region, donor BJ, cell39. Homo sapiens partial IGVL2b2 gene for GP:AJ415108_1 immunoglobulin lambda chain variable K.LMIYEVSQ.R 1 2.010 0.081 G, P region, donor BJ, cell115. Homo sapiens partial IGVL1c gene for GP:AJ415118_1 immunoglobulin lambda chain variable G.STTVNWYRQLPGTAPK.L 2 2.496 0.178 O region, donor MF, cell64. Homo sapiens partial IGVL1b gene for GP:AJ415124_1 immunoglobulin lambda chain variable N.SVSWYQQLPGTAPK.L 2 2.439 0.231 G region, donor MF, cell71. Homo sapiens partial IGVLIGGLL150 GP:AJ415143_1 gene for immunoglobulin lambda chain X.PGQAPLLVIYK.D 1 2.095 0.212 G variable region, donor MF, cell10. Homo sapiens partial IGVL6a gene for GP:AJ415148_1 immunoglobulin lambda chain variable T.IXIYDDNQR.P 2 2.389 0.117 G region, donor MF, cell17. Homo sapiens partial IGVL1g gene for GP:AJ415154_1 immunoglobulin lambda chain variable D.RFSGSTSGPSASLTISGLRA.E 2 2.696 0.124 A region, donor MF, cell29. Homo sapiens partial IGVH3-30 gene for GP:AJ415254_1 immunoglobulin heavy chain variable K.NTLNLQMNSLR.P 1 2.023 0.098 G region, donor MF, cell66. Homo sapiens partial IGVH3-74 gene for GP:AJ415346_1 immunoglobulin heavy chain variable -.EEQLVESGGGLVR.S 2 2.392 0.219 G region, donor MF, cell73. GP:AJ415407_1 Homo sapiens partial IGVKO18 gene for N.YLKWYQQKPGK.A 2 2.216 0.105 G IPI:IPI00003111.1
Supplementary Table 2 37 immunoglobulin kappa chain variable (92%) region, donor MF, cell73. Homo sapiens partial IGVL1e gene for IPI:IPI00179702.1 GP:AJ415814_1 immunoglobulin lambda chain variable K.VLIFSNTNRPSGVPDR.V 2 2.425 0.106 O (93%) region, donor BJ, cell53. Homo sapiens partial IGVL1g gene for GP:AJ415830_1 immunoglobulin lambda chain variable S.SSQRPSGVPDR.F 2 2.256 0.200 O region, donor BJ, cell84. Homo sapiens partial mRNA for GP:AJ416560_1 immunoglobulin heavy chain variable V.KPSQTLSLTCTVSGGSISSGENYW.T 2 2.566 0.148 O region (IGVH gene), isolate CLL044. GP:AJ417081_1 Homo sapiens mRNA for PREP2 protein. D.PELDNLMVKAIQVLRI.H 1 2.132 0.084 G Homo sapiens partial IGVH3-23 gene for GP:AJ421277_1 immunoglobulin heavy chain variable N.CKSALHLQMNNLQGEDTAVY.Y 2 2.410 0.118 O region, isolate case 1, f2-14. Homo sapiens cDNA FLJ20030 fis, clone IPI:IPI00014402.1 GP:AK000037_1 R.LQHLAESWGGKENGFGLAECCRD.L 2 2.537 0.124 P ADSU02156; unnamed protein product. (97%) Homo sapiens cDNA FLJ20047 fis, clone IPI:IPI00014829.1 GP:AK000054_1 Y.SVLTLSATDLESNENI.S 1 2.191 0.136 G COL00577; unnamed protein product. (97%) Homo sapiens cDNA FLJ20071 fis, clone GP:AK000078_1 L.LLYTLLHQNSNIRTYMLARTD.M 2 2.463 0.132 P COL01887; unnamed protein product. Homo sapiens cDNA FLJ20080 fis, clone IPI:IPI00014875.1 GP:AK000087_1 G.GSHSNKKLLSSLGIDTRNI.L 2 2.530 0.326 P COL03184; unnamed protein product. (92%) Homo sapiens cDNA FLJ20125 fis, clone IPI:IPI00185223.1 GP:AK000132_1 A.CQHCQVAK.N 2 2.290 0.156 O COL06152; unnamed protein product. (99%) Homo sapiens cDNA FLJ20142 fis, clone IPI:IPI00014952.1 GP:AK000149_1 Q.RKLILQGQLSEAALQKQHQR.N 2 2.213 0.137 A COL07365; unnamed protein product. (97%) Homo sapiens cDNA FLJ20211 fis, clone IPI:IPI00164992.1 GP:AK000218_1 Q.KEPHPLQFLREANAGNLKPLFEF.V 2 2.423 0.114 G COLF1807; unnamed protein product. (94%) Homo sapiens cDNA FLJ20212 fis, clone IPI:IPI00100706.1 GP:AK000219_1 E.DGVLGGVIVL.R 1 2.198 0.090 A COLF1860; unnamed protein product. (96%) Homo sapiens cDNA FLJ20220 fis, clone IPI:IPI00184406.1 GP:AK000227_1 L.FGRYYRVAFYGQGFFEEEEGKEYI.Y 2 2.471 0.122 A COLF3372; unnamed protein product. (95%) Homo sapiens cDNA FLJ20245 fis, clone GP:AK000252_1 G.PDVGTGAPRPGCSPR.A 2 2.347 0.224 O COLF6454; unnamed protein product. Homo sapiens cDNA FLJ20272 fis, clone IPI:IPI00180281.1 GP:AK000279_1 G.CAYLALEDYQGSAKAFQR.C 2 2.591 0.093 A HEP01722; unnamed protein product. (99%) Homo sapiens cDNA FLJ20276 fis, clone IPI:IPI00166156.1 GP:AK000283_1 L.LANEKVEEFTTFV.K 2 2.601 0.092 G HEP02437; unnamed protein product. (98%) Homo sapiens cDNA FLJ20307 fis, clone IPI:IPI00161472.1 GP:AK000314_1 E.ASGKHSSDIIVGPEGGSL.E 2 2.441 0.109 G HEP07254; unnamed protein product. (94%) Homo sapiens cDNA FLJ20318 fis, clone IPI:IPI00217355.1 GP:AK000325_1 N.NSNSSLLLMNGPGSLFASENF.L 2 2.434 0.161 G HEP08704; unnamed protein product. (96%) Homo sapiens cDNA FLJ20321 fis, clone GP:AK000328_1 S.PAAEPSPFLGKAVKALVQEKL.A 2 2.643 0.086 P HEP09380; unnamed protein product. Homo sapiens cDNA FLJ20330 fis, clone GP:AK000337_1 W.QNIAIMTEEP.E 2 2.709 0.109 G HEP10296; unnamed protein product. Homo sapiens cDNA FLJ20340 fis, clone D.YVNMTGLDLSAIQERQLWVAFQCCRDYE GP:AK000347_1 2 2.640 0.119 A HEP12374; unnamed protein product. NV.P Homo sapiens cDNA FLJ20359 fis, clone L.GGFLLPKGTPVIPLLTSVLLDETQWQTPGQ IPI:IPI00183606.1 GP:AK000366_1 2 2.462 0.130 O HEP16626; unnamed protein product. FNPG.H (99%) Homo sapiens cDNA FLJ20365 fis, clone IPI:IPI00008918.1 GP:AK000372_1 P.RSRLRSPPEALV.Q 2 2.713 0.080 A HEP17877; unnamed protein product. (94%) Homo sapiens cDNA FLJ20392 fis, clone IPI:IPI00015790.1 GP:AK000399_1 D.ADPEVLLSETIRHFRLYSQK.A 2 2.259 0.207 A KAIA4653; unnamed protein product. (96%) Homo sapiens cDNA FLJ20515 fis, clone IPI:IPI00016485.1 GP:AK000522_1 Q.RQHLHLMVQLLR.P 2 2.343 0.105 P KAT09889; unnamed protein product. (91%) Homo sapiens cDNA FLJ20527 fis, clone GP:AK000534_1 S.NSIYFSIAIVSEDFVPYKGDL.L 2 2.549 0.101 G KAT10701; unnamed protein product. Homo sapiens cDNA FLJ20542 fis, clone IPI:IPI00063336.1 GP:AK000549_1 Y.MPANGETVTLPTSPSIPVGISL.G 2 2.505 0.110 O KAT11395; unnamed protein product. (98%) Homo sapiens cDNA FLJ20636 fis, clone GP:AK000643_1 F.LEREGASLPK.P 1 2.038 0.098 O KAT03434; unnamed protein product. Homo sapiens cDNA FLJ20712 fis, clone IPI:IPI00017293.1 GP:AK000719_1 T.PQALLVGV.G 1 2.163 0.103 A HUV01027; unnamed protein product. (94%) Homo sapiens cDNA FLJ20733 fis, clone IPI:IPI00017332.1 GP:AK000740_1 T.SDLMENTYGNPHSQNISSK.L 2 2.227 0.197 G HEP08550; unnamed protein product. (98%) Homo sapiens cDNA FLJ20746 fis, clone IPI:IPI00004568.1 GP:AK000753_1 A.VAEICTEMLRQFTGNPNIPKPRR.I 2 2.324 0.120 G HEP06040; unnamed protein product. (95%) Homo sapiens cDNA FLJ20821 fis, clone GP:AK000828_1 D.FEEDNEDDDENRVNQEEKA.A 2 2.416 0.115 O ADSE00469; unnamed protein product. Homo sapiens cDNA FLJ20850 fis, clone GP:AK000857_1 A.RYRSTVHGVDPGLRRRLAGG.A 2 2.502 0.215 A ADKA01542; unnamed protein product. Homo sapiens cDNA FLJ10044 fis, clone IPI:IPI00183396.1 GP:AK000906_1 HEMBA1001088, moderately similar to L.FAPCCGSCGEFIIGR.V 2 2.288 0.215 G (97%) PINCH PROTEIN; unnamed protein Supplementary Table 2 38 product. Homo sapiens cDNA FLJ10066 fis, clone HEMBA1001510, weakly similar to IPI:IPI00044987.1 GP:AK000928_1 CYCLIC-AMP-DEPENDENT P.KPVVLTTVPMPSRAV.P 2 2.627 0.221 P (92%) TRANSCRIPTION FACTOR ATF-6; unnamed protein product. Homo sapiens cDNA FLJ10139 fis, clone IPI:IPI00217304.1 GP:AK001001_1 HEMBA1003175; unnamed protein E.LTCFSKTSL.L 1 2.256 0.086 A (97%) product. Homo sapiens cDNA FLJ10178 fis, clone IPI:IPI00017545.1 GP:AK001040_1 HEMBA1004146; unnamed protein L.DDMPENCICDVIG.L 2 2.435 0.111 O (99%) product. Homo sapiens cDNA FLJ10201 fis, clone GP:AK001063_1 HEMBA1004923; unnamed protein A.TVGTCKAATPTVVSTTSLV.P 1 2.371 0.165 O product. Homo sapiens cDNA FLJ10455 fis, clone IPI:IPI00161970.2 GP:AK001317_1 NT2RP1001014; unnamed protein P.GLEVPSSPLRKAK.R 2 2.289 0.150 A (91%) product. Homo sapiens cDNA FLJ10469 fis, clone NT2RP2000008, weakly similar to ZINC IPI:IPI00218973.1 GP:AK001331_1 I.TERENVFGETLNLGMNSVPSRKMPY.K 2 2.428 0.110 A FINGER PROTEIN 84; unnamed protein (99%) product. Homo sapiens cDNA FLJ10482 fis, clone GP:AK001344_1 NT2RP2000153, weakly similar to GAR2 D.YPSNTTSSTSNSGNETSGSSTI.G 2 2.907 0.088 P PROTEIN; unnamed protein product. Homo sapiens cDNA FLJ10498 fis, clone GP:AK001360_1 NT2RP2000328; unnamed protein R.KKTKTNPFSSSTNKEK.K 1 1.937 0.174 P product. Homo sapiens cDNA FLJ10507 fis, clone IPI:IPI00019026.1 GP:AK001369_1 NT2RP2000516; unnamed protein L.ALAPRKPQPCRCRRRVRPSIR.L 2 2.207 0.110 G (97%) product. Homo sapiens cDNA FLJ10540 fis, clone IPI:IPI00018688.1 GP:AK001402_1 NT2RP2001245; unnamed protein K.QQEEQTRVALLEQQMQACTLDFENEK.L 3 3.596 0.147 A (93%) product. Homo sapiens cDNA FLJ10560 fis, clone IPI:IPI00018696.1 GP:AK001422_1 NT2RP2002621; unnamed protein T.ASFHSTHSSLVSR.E 2 2.435 0.148 P (94%) product. Homo sapiens cDNA FLJ10563 fis, clone IPI:IPI00018698.1 GP:AK001425_1 NT2RP2002769; unnamed protein T.NMQDGSVQVIKDHVT.N 2 3.027 0.113 P (93%) product. Homo sapiens cDNA FLJ10619 fis, clone IPI:IPI00018767.1 GP:AK001481_1 NT2RP2005472; unnamed protein P.EQANAAVPDSVALESDSVGTYLPGAS.R 2 3.147 0.125 G (98%) product. Homo sapiens cDNA FLJ10620 fis, clone IPI:IPI00018771.1 GP:AK001482_1 NT2RP2005495; unnamed protein K.WTDEYESAIDHN.G 1 2.078 0.081 G (93%) product. Homo sapiens cDNA FLJ10651 fis, clone IPI:IPI00175418.1 GP:AK001513_1 NT2RP2005868; unnamed protein Q.LIGVGLLSVLHRLL.L 1 2.075 0.101 P (93%) product. Homo sapiens cDNA FLJ10694 fis, clone NT2RP3000397, weakly similar to S.ILASCEFDCVDEVLTIAAMVTAPNCFSHVP IPI:IPI00043989.1 GP:AK001556_1 PUTATIVE PRE-MRNA SPLICING 3 3.830 0.207 G HGAEEA.A (98%) FACTOR RNA HELICASE; unnamed protein product. Homo sapiens cDNA FLJ10747 fis, clone GP:AK001609_1 NT2RP3001799; unnamed protein S.TFLYLKF.L 1 2.007 0.083 A product. Homo sapiens cDNA FLJ10783 fis, clone NT2RP4000417, weakly similar to IPI:IPI00031259.2 GP:AK001645_1 MANNOSYL-OLIGOSACCHARIDE D.VLTGKWVAQDAGIGAGVDSYF.E 2 2.989 0.081 P (92%) ALPHA-1,2-MANNOSIDASE (EC 3.2.1.113); unnamed protein product. Homo sapiens cDNA FLJ10787 fis, clone NT2RP4000481, weakly similar to ATP- IPI:IPI00217606.1 GP:AK001649_1 K.LHCLTVVFLLHLPLSQRACAR.V 2 2.316 0.215 O DEPENDENT RNA HELICASE DOB1; (99%) unnamed protein product. Homo sapiens cDNA FLJ10791 fis, clone IPI:IPI00010187.1 GP:AK001653_1 NT2RP4000556, weakly similar to SUR4 A.LQQNGAPGIAKVK.A 2 2.401 0.113 G (99%) PROTEIN; unnamed protein product. Homo sapiens cDNA FLJ10811 fis, clone GP:AK001673_1 NT2RP4000955; unnamed protein L.EHCISLNTLVPYRCFK.R 1 1.855 0.094 G product. Homo sapiens cDNA FLJ10821 fis, clone GP:AK001683_1 NT2RP4001057; unnamed protein G.WEPNDLAFFVDIQLPDLLMK.M 2 2.353 0.134 A product. GP:AK001780_1 Homo sapiens cDNA FLJ10918 fis, clone A.FKDVALVLTVLLEEETLGTSLGL.K 2 2.508 0.121 P
Supplementary Table 2 39 OVARC1000326; unnamed protein product. Homo sapiens cDNA FLJ10979 fis, clone IPI:IPI00181824.1 GP:AK001841_1 PLACE1001503; unnamed protein T.SSGGLTISSLLKEK.E 2 2.529 0.119 P (96%) product. Homo sapiens cDNA FLJ11111 fis, clone GP:AK001973_1 PLACE1005923; unnamed protein T.SVQSKFARLAKKKENITY.M 2 2.486 0.109 P product. Homo sapiens cDNA FLJ11222 fis, clone GP:AK002084_1 PLACE1008177; unnamed protein A.IIEEERLKLLKEHATNLLGY.L 2 2.813 0.139 O product. Homo sapiens cDNA FLJ11391 fis, clone HEMBA1000569, weakly similar to GPI- IPI:IPI00029369.1 GP:AK021453_1 E.PKDAPKPVHQPVGSSSTLPKDPVLR.K 2 2.202 0.145 P ANCHORED PROTEIN P137; unnamed (95%) protein product. Homo sapiens cDNA FLJ11477 fis, clone HEMBA1001746, weakly similar to Homo IPI:IPI00186813.1 GP:AK021539_1 sapiens squamous cell carcinoma Q.YFAMNKDKKKK.I 2 2.580 0.154 A (99%) antigen recognized by T cell (SART-2) mRNA; unnamed protein product. Homo sapiens cDNA FLJ11633 fis, clone IPI:IPI00029311.1 GP:AK021695_1 HEMBA1004274; unnamed protein R.EIKSVMNTAGNSAPSLFLKSN.F 2 2.552 0.205 P (94%) product. Homo sapiens cDNA FLJ12189 fis, clone MAMMA1000841, moderately similar to IPI:IPI00024019.1 GP:AK022251_1 L.DQGALLMGKTNLDEFAMGS.G 1 2.013 0.123 O PUTATIVE AMIDASE (EC 3.5.1.4); (95%) unnamed protein product. Homo sapiens cDNA FLJ12442 fis, clone NT2RM1000153, weakly similar to IPI:IPI00009662.1 GP:AK022504_1 CYTOSOLIC PURINE 5'- Y.ADNEISLRDVEVYGFDYDYTL.A 2 2.462 0.156 G (96%) NUCLEOTIDASE (EC 3.1.3.5); unnamed protein product. Homo sapiens cDNA FLJ12448 fis, clone GP:AK022510_1 NT2RM1000300; unnamed protein A.GAANSQLSTSQPSL.R 2 2.494 0.100 G product. Homo sapiens cDNA FLJ12455 fis, clone NT2RM1000563, weakly similar to IPI:IPI00171544.1 GP:AK022517_1 TRANSMISSION-BLOCKING TARGET T.VYLVVSGIPSVLRSAHL.R 2 2.414 0.166 G (93%) ANTIGEN S230 PRECURSOR; unnamed protein product. Homo sapiens cDNA FLJ12465 fis, clone V.KNDYAVESYENKGAYQRGAAPKCRILPAG IPI:IPI00215787.1 GP:AK022527_1 NT2RM1000802; unnamed protein 3 3.566 0.113 A GK.V (92%) product. Homo sapiens cDNA FLJ12476 fis, clone IPI:IPI00009722.1 GP:AK022538_1 NT2RM1000978; unnamed protein Y.SDQLALTQLTLYLTNGHLDCSL.S 2 2.818 0.146 O (96%) product. Homo sapiens cDNA FLJ12485 fis, clone IPI:IPI00004697.1 GP:AK022547_1 NT2RM2000420; unnamed protein L.KFMHTSHQFLLLSSPPAKEARFR.T 3 3.672 0.087 G (93%) product. Homo sapiens cDNA FLJ12500 fis, clone IPI:IPI00178184.1 GP:AK022562_1 NT2RM2001675; unnamed protein H.VATCGNVLFEGRTVQLGK.L 2 2.313 0.245 P (97%) product. Homo sapiens cDNA FLJ12519 fis, clone IPI:IPI00181721.1 GP:AK022581_1 NT2RM2001813; unnamed protein E.PRPLYIQKGISREKV.Q 2 2.584 0.156 G, O (99%) product. Homo sapiens cDNA FLJ12526 fis, clone NT2RM4000046, weakly similar to GP:AK022588_1 K.PIASPSE.A 1 1.898 0.103 G GOLIATH PROTEIN; unnamed protein product. Homo sapiens cDNA FLJ12528 fis, clone NT2RM4000155, moderately similar to IPI:IPI00018632.1 GP:AK022590_1 THREONYL-TRNA SYNTHETASE, S.PEGKAVFWHSSTHVLGAAAEQF.L 2 2.611 0.132 G (97%) CYTOPLASMIC (EC 6.1.1.3); unnamed protein product. Homo sapiens cDNA FLJ12615 fis, clone NT2RM4001629, weakly similar to IPI:IPI00174976.1 GP:AK022677_1 P.YVPCRELGLSFQKGDIL.H 2 2.527 0.120 A MAGUK P55 SUBFAMILY MEMBER 3; (96%) unnamed protein product. Homo sapiens cDNA FLJ12618 fis, clone NT2RM4001666, weakly similar to IPI:IPI00016458.1 GP:AK022680_1 HYPOTHETICAL 48.6 KD PROTEIN IN I.RCQYVVTCAGLYSDRISEL.S 2 2.438 0.112 P (95%) ALPA-GABP INTERGENIC REGION; unnamed protein product. Homo sapiens cDNA FLJ12634 fis, clone NT2RM4001858, weakly similar to T- IPI:IPI00217300.1 GP:AK022696_1 P.DCMFGCTCLKRKV.V 1 2.230 0.116 G BOX CONTAINING PROTEIN TBX6L; (95%) unnamed protein product. Supplementary Table 2 40 Homo sapiens cDNA FLJ12724 fis, clone NT2RP1001385, weakly similar to IPI:IPI00019349.1 GP:AK022786_1 HYPOTHETICAL 48.8 KD PROTEIN IN D.YSEWDLSTDAGERARLLQSPCVDTA.P 2 2.467 0.156 A (99%) SSU81-SCS2 INTERGENIC REGION; unnamed protein product. Homo sapiens cDNA FLJ12761 fis, clone NT2RP2001378, weakly similar to IPI:IPI00181113.1 GP:AK022823_1 V.RYVPVRPRPPITLLRHYR.N 2 2.235 0.123 A MUCIN 2 PRECURSOR; unnamed (91%) protein product. Homo sapiens cDNA FLJ12765 fis, clone NT2RP2001511, moderately similar to IPI:IPI00186652.1 GP:AK022827_1 Homo sapiens putative RNA-binding K.FVSRVSWHLLHEVLTGRTLPEPLELDKP.I 3 3.526 0.182 O (99%) protein Q99 mRNA; unnamed protein product. Homo sapiens cDNA FLJ12800 fis, clone NT2RP2002079, weakly similar to GP:AK022862_1 Q.LVAFLQGLRDDGFQPTI.L 2 2.608 0.087 O HISTONE H1, GONADAL; unnamed protein product. Homo sapiens cDNA FLJ12812 fis, clone IPI:IPI00149849.1 GP:AK022874_1 NT2RP2002498; unnamed protein W.RLTPAEVRQ.V 1 2.138 0.140 G (96%) product. Homo sapiens cDNA FLJ12855 fis, clone NT2RP2003506, weakly similar to IPI:IPI00160674.2 GP:AK022917_1 NADPH-CYTOCHROME P450 L.YVSVDASTKDSLKRIDRPLFK.D 2 2.344 0.104 O (96%) REDUCTASE (EC 1.6.2.4); unnamed protein product. Homo sapiens cDNA FLJ12871 fis, clone IPI:IPI00185224.1 GP:AK022933_1 NT2RP2003751; unnamed protein V.LALLITARCVVPALHLVNTEV.D 2 2.533 0.139 G (97%) product. Homo sapiens cDNA FLJ12875 fis, clone IPI:IPI00100060.1 GP:AK022937_1 NT2RP2003777; unnamed protein F.TDVIGHYISGERPKGIQE.T 1 2.015 0.105 O (99%) product. Homo sapiens cDNA FLJ12879 fis, clone NT2RP2003857, weakly similar to GP:AK022941_1 L.GASSLHVNGESLEMD.S 1 2.253 0.122 P MYOTROPHIN; unnamed protein product. Homo sapiens cDNA FLJ12888 fis, clone IPI:IPI00181509.1 GP:AK022950_1 NT2RP2004081; unnamed protein N.KIKQTSSSDSHSLNNKI.L 2 2.536 0.162 O (99%) product. Homo sapiens cDNA FLJ12940 fis, clone NT2RP2005038, weakly similar to DNA IPI:IPI00002325.1 GP:AK023002_1 H.SSRVVQELLEHGVCEEVERVR.R 2 2.361 0.162 O NUCLEOTIDYLEXOTRANSFERASE (92%) (EC 2.7.7.31); unnamed protein product. Homo sapiens cDNA FLJ12954 fis, clone NT2RP2005491, weakly similar to IPI:IPI00177967.1 GP:AK023016_1 I.DSFSQASNVTSQLPGFPKYPSHTK.A 2 2.206 0.219 G PARAMYOSIN; unnamed protein (92%) product. Homo sapiens cDNA FLJ12969 fis, clone NT2RP2005841, weakly similar to Homo IPI:IPI00010229.1 GP:AK023031_1 L.KLTKDPFIHEIATM.I 1 2.068 0.109 P sapiens mRNA for ALEX3; unnamed (92%) protein product. Homo sapiens cDNA FLJ13031 fis, clone NT2RP3001113, weakly similar to IPI:IPI00183694.1 GP:AK023093_1 INTRACELLULAR PROTEIN N.ESVISVHQDSKSKLQMQEK.K 2 2.440 0.123 A (97%) TRANSPORT PROTEIN USO1; unnamed protein product. Homo sapiens cDNA FLJ13080 fis, clone IPI:IPI00165124.1 GP:AK023142_1 NT2RP3002007, weakly similar to SAP1 A.QILRIQYAWANSEISQVCA.T 2 2.621 0.123 O (98%) PROTEIN; unnamed protein product. Homo sapiens cDNA FLJ13117 fis, clone GP:AK023179_1 NT2RP3002660; unnamed protein M.KQAFAELESCLMDR.E 2 2.578 0.184 O product. Homo sapiens cDNA FLJ13119 fis, clone NT2RP3002671, weakly similar to IPI:IPI00182077.1 GP:AK023181_1 K.RKGLYVEE.K 1 1.907 0.087 P ELONGATION FACTOR 2; unnamed (96%) protein product. Homo sapiens cDNA FLJ13138 fis, clone NT2RP3003197, weakly similar to IPI:IPI00091590.1 GP:AK023200_1 HYPOTHETICAL 33.8 KD PROTEIN A.PAFERFCQVNTGPLPLL.G 2 2.536 0.199 A (99%) C5H10.01 IN CHROMOSOME I; unnamed protein product. Homo sapiens cDNA FLJ13140 fis, clone GP:AK023202_1 NT2RP3003204; unnamed protein A.VRAIVPNKSNNEIILVLQHFDNCV.D 2 2.515 0.134 A product. Homo sapiens cDNA FLJ13150 fis, clone IPI:IPI00217668.1 GP:AK023212_1 NT2RP3003353, weakly similar to F.ITPAHYSDVVDER.S 1 1.859 0.083 G (93%) HYPOTHETICAL 26.2 KD PROTEIN IN Supplementary Table 2 41 GDI1-COX15 INTERGENIC REGION; unnamed protein product. Homo sapiens cDNA FLJ13158 fis, clone GP:AK023220_1 NT2RP3003552; unnamed protein Q.KLLKFLNK.H 2 2.329 0.147 O product. Homo sapiens cDNA FLJ13241 fis, clone GP:AK023303_1 OVARC1000557; unnamed protein Y.CSLDLPGSGDHPTSASRIAGTA.G 2 2.426 0.150 O product. Homo sapiens cDNA FLJ13355 fis, clone IPI:IPI00020054.1 GP:AK023417_1 PLACE1000048; unnamed protein L.WQQISNCMPDLALCRCL.E 1 2.271 0.358 O (94%) product. Homo sapiens cDNA FLJ13465 fis, clone PLACE1003493, weakly similar to IPI:IPI00015525.1 GP:AK023527_1 S.LAVDAHKAEGERAR.A 2 2.395 0.125 G ENDOTHELIAL CELL MULTIMERIN (91%) PRECURSOR; unnamed protein product. Homo sapiens cDNA FLJ13488 fis, clone PLACE1003915, weakly similar to IPI:IPI00184353.1 GP:AK023550_1 PROBABLE ARGINYL-TRNA A.LIIQDFKGLLL.S 2 2.756 0.152 O (94%) SYNTHETASE, CYTOPLASMIC (EC 6.1.1.19); unnamed protein product. Homo sapiens cDNA FLJ13576 fis, clone IPI:IPI00152949.1 GP:AK023638_1 PLACE1008715; unnamed protein A.HGLFHELGNCLGGTSVGYA.I 2 2.496 0.112 P (99%) product. Homo sapiens cDNA FLJ13670 fis, clone IPI:IPI00017927.3 GP:AK023732_1 PLACE1011725; unnamed protein V.FTSSAMYGIPHLLTMSLKFS.T 2 2.556 0.179 O (91%) product. Homo sapiens cDNA FLJ13725 fis, clone PLACE3000009, weakly similar to DNA- GP:AK023787_1 DIRECTED RNA POLYMERASE II T.PSSGPLDEEGAVAPVLANGHA.P 2 2.405 0.260 G LARGEST SUBUNIT (EC 2.7.7.6); unnamed protein product. Homo sapiens cDNA FLJ13772 fis, clone IPI:IPI00010251.2 GP:AK023834_1 PLACE4000300; unnamed protein R.PVKQSRKFVPGCFVCLESRT.C 2 2.633 0.169 O (93%) product. Homo sapiens cDNA FLJ13824 fis, clone IPI:IPI00003033.1 GP:AK023886_1 THYRO1000505; unnamed protein A.QDLERVPPGLLALDNMLY.F 2 2.569 0.128 G (95%) product. Homo sapiens cDNA FLJ13840 fis, clone THYRO1000783, moderately similar to GP:AK023902_1 Xenopus laevis tail-specific thyroid S.KFIISFAEDEAGELYFLA.T 2 2.611 0.152 A hormone up-regulated (gene 5) mRNA; unnamed protein product. Homo sapiens cDNA FLJ13906 fis, clone Y79AA1000013, moderately similar to IPI:IPI00059944.1 GP:AK023968_1 S.ASAAAGEEDWVLPSEVEVLESI.Y 2 2.832 0.156 P Mus musculus RING finger protein AO7 (93%) mRNA; unnamed protein product. Homo sapiens cDNA FLJ13916 fis, clone Y79AA1000342, moderately similar to GP:AK023978_1 E.GDEEEEEDDEDEEEIK.V 2 2.439 0.106 A Homo sapiens Ciz1 mRNA; unnamed protein product. Homo sapiens cDNA FLJ13955 fis, clone IPI:IPI00028844.1 GP:AK024017_1 Y79AA1001177; unnamed protein L.FGVLLAILGNLVISISLNIQKY.S 2 2.405 0.126 A (96%) product. Homo sapiens cDNA FLJ13967 fis, clone Y79AA1001402, weakly similar to Homo GP:AK024029_1 sapiens paraneoplastic cancer-testis- L.TTHQKDEEKLS.A 2 2.616 0.104 O brain antigen (MA4) mRNA; unnamed protein product. Homo sapiens cDNA FLJ14026 fis, clone HEMBA1003679, weakly similar to GP:AK024088_1 Q.NTCKSPPKMSKPGSPGSVI.P 2 2.401 0.166 A SIALIDASE (EC 3.2.1.18); unnamed protein product. Homo sapiens cDNA FLJ14195 fis, clone NT2RP3001723, weakly similar to Homo IPI:IPI00043906.1 GP:AK024257_1 sapiens cell recognition molecule Caspr2 I.LMMELAHGLQDQNLKI.S 1 2.333 0.111 G (99%) (CASPR2) mRNA; unnamed protein product. Homo sapiens cDNA FLJ14262 fis, clone GP:AK024324_1 PLACE1001608; unnamed protein S.MQRPRANSCATRSSSGESLAQSPDSSK.S 2 2.587 0.150 O product. Homo sapiens cDNA FLJ14266 fis, clone PLACE1002437, highly similar to ATP- IPI:IPI00178915.1 GP:AK024328_1 T.VPRSAAVAATGDAK.P 2 2.439 0.106 G BINDING CASSETTE TRANSPORTER (99%) 1; unnamed protein product. Homo sapiens cDNA FLJ14298 fis, clone GP:AK024360_1 PLACE1009935; unnamed protein A.FSDCREKVPRFK.F 2 2.335 0.110 A product. Supplementary Table 2 42 Homo sapiens cDNA FLJ14327 fis, clone GP:AK024389_1 PLACE4000250; unnamed protein L.PSTAPLMGESVGLMLRSFGLSFC.L 2 2.946 0.170 A product. Homo sapiens mRNA for FLJ00050 protein, partial cds; For this clone, the longest ORF was tentatively assigned as GP:AK024458_1 R.PPAPAWKGQVLPHLLSPK.K 2 2.459 0.251 A CDS because GeneMark analysis failed to detect any CDS. Start codon is not identified.. Homo sapiens mRNA for FLJ00056 R.VEEEAWDLDVKQISLAPETLDSSGDVSPG GP:AK024463_1 protein, partial cds; Start codon is not 3 3.721 0.185 G PRNSP.S identified.. Homo sapiens mRNA for FLJ00106 GP:AK024498_1 protein, partial cds; Start codon is not C.STSIANQAVRIQEGRYR.H 2 2.270 0.211 A identified.. Homo sapiens cDNA: FLJ20876 fis, GP:AK024529_1 clone ADKA02905; unnamed protein R.SGVVSSATFEQPSR.Q 2 2.399 0.122 G, O product. Homo sapiens cDNA: FLJ20991 fis, P.PSVASIKVSAELLRAALKDGHSGVPLCCAT IPI:IPI00025377.1 GP:AK024644_1 clone CAE02103; unnamed protein 2 2.576 0.197 A LQWLL.A (96%) product. Homo sapiens cDNA: FLJ21001 fis, IPI:IPI00015578.1 GP:AK024654_1 clone CAE03418; unnamed protein P.FDAQTTGDGTEDPSL.T 1 2.083 0.130 G (96%) product. Homo sapiens cDNA: FLJ21032 fis, GP:AK024685_1 clone CAE07365; unnamed protein L.MSLLHLGAVYSLVLIPK.A 2 2.264 0.147 A product. Homo sapiens cDNA: FLJ21129 fis, IPI:IPI00165927.1 GP:AK024782_1 clone CAS06266; unnamed protein Q.HVYIPVLPPHLLDY.C 2 2.484 0.260 G (99%) product. Homo sapiens cDNA: FLJ21369 fis, GP:AK025022_1 clone COL03091; unnamed protein T.CENPAVNKPLLSLGAYVPGGKV.Y 2 2.505 0.254 A product. Homo sapiens cDNA: FLJ21477 fis, IPI:IPI00018636.1 GP:AK025130_1 clone COL04982; unnamed protein H.RGNQIKTSKYTVLSFVPKNI.F 2 2.986 0.338 P (96%) product. Homo sapiens cDNA: FLJ21702 fis, IPI:IPI00180928.1 GP:AK025355_1 clone COL09874; unnamed protein K.GGPLRALSSKTWSTDDFFAGLR.E 2 2.543 0.173 O (98%) product. Homo sapiens cDNA: FLJ21742 fis, IPI:IPI00167135.1 GP:AK025395_1 clone COLF4912; unnamed protein L.AADRTLHSTRSRADYPQSH.V 2 2.736 0.103 O, P (97%) product. Homo sapiens cDNA: FLJ21833 fis, IPI:IPI00179104.1 GP:AK025486_1 clone HEP01592; unnamed protein E.VCLDLRPGTNYNVSL.R 2 2.882 0.123 G (97%) product. Homo sapiens cDNA: FLJ21919 fis, GP:AK025572_1 clone HEP04019; unnamed protein L.AEHIKSLLIKNNSLPRKRQS.L 2 2.437 0.151 P product. Homo sapiens cDNA: FLJ21972 fis, IPI:IPI00184229.1 GP:AK025625_1 clone HEP05845; unnamed protein I.QAAIAQLDLLGALEHKDDQ.L 2 2.459 0.106 G (98%) product. Homo sapiens cDNA: FLJ22031 fis, IPI:IPI00026567.2 GP:AK025684_1 clone HEP08734; unnamed protein R.PMATGDTFTY.E 1 1.834 0.130 A (95%) product. Homo sapiens cDNA: FLJ22222 fis, IPI:IPI00002884.1 GP:AK025875_1 clone HRC01658; unnamed protein F.VNLYRYFGDKIQNIFSE.E 2 2.440 0.106 A (91%) product. Homo sapiens cDNA: FLJ22313 fis, F.RQEGGHQQAPNNNAEVNNDGQNANNLE GP:AK025966_1 clone HRC05216; unnamed protein 3 3.565 0.121 O LEEMER.L product. Homo sapiens cDNA: FLJ22315 fis, GP:AK025968_1 clone HRC05256; unnamed protein A.QDVTGALEDALAKVTKII.L 1 2.475 0.106 G product. Homo sapiens cDNA: FLJ22362 fis, GP:AK026015_1 clone HRC06544; unnamed protein V.HFRTLKGSDRLPSNSSSPGDIT.V 2 2.812 0.125 P product. Homo sapiens cDNA: FLJ22476 fis, GP:AK026129_1 clone HRC10682; unnamed protein P.SPASCPAGLACPSLD.I 2 3.007 0.126 O product. Homo sapiens cDNA: FLJ22489 fis, L.CHHCTGRGGAGSGGAGSGAAGGTGGSG IPI:IPI00170795.1 GP:AK026142_1 clone HRC10951; unnamed protein 2 2.465 0.156 G GGGFGA.A (97%) product. Homo sapiens cDNA: FLJ22494 fis, IPI:IPI00015728.1 GP:AK026147_1 clone HRC11131; unnamed protein V.AFRSPGIQDEPPKVR.G 2 2.498 0.146 O (94%) product. GP:AK026184_1 Homo sapiens cDNA: FLJ22531 fis, R.ALRSARAPSPSEAAPRRPEA.T 2 2.471 0.183 O, P
Supplementary Table 2 43 clone HRC12890; unnamed protein product. Homo sapiens cDNA: FLJ22659 fis, GP:AK026312_1 clone HSI07953; unnamed protein P.SSQSRGKARHMPLIW.E 2 2.509 0.138 A product. Homo sapiens cDNA: FLJ22673 fis, IPI:IPI00165008.1 GP:AK026326_1 clone HSI10503; unnamed protein A.IPIAKRCITAVSLNNLIYVAGGLTK.A 2 2.373 0.104 G (96%) product. Homo sapiens cDNA: FLJ22684 fis, GP:AK026337_1 clone HSI10821; unnamed protein T.KKELIVNKKK.H 1 1.961 0.096 P product. Homo sapiens cDNA: FLJ23003 fis, IPI:IPI00004151.1 GP:AK026656_1 clone LNG00331; unnamed protein L.CQWSLRSVPCPTCPSR.P 2 2.307 0.122 O (93%) product. Homo sapiens cDNA: FLJ23040 fis, GP:AK026693_1 clone LNG02277; unnamed protein L.EAELQAPDITPDMYDPN.T 1 2.072 0.104 G product. Homo sapiens cDNA: FLJ23129 fis, GP:AK026782_1 clone LNG08404; unnamed protein Y.DSYNAMELVSLSVKQSVVE.S 2 2.689 0.104 P product. Homo sapiens cDNA: FLJ23164 fis, IPI:IPI00024703.1 GP:AK026817_1 clone LNG09764; unnamed protein L.EAANVKLSEVDTE.W 2 2.701 0.088 O (95%) product. Homo sapiens cDNA: FLJ23205 fis, IPI:IPI00152967.1 GP:AK026858_1 clone ADSE00359; unnamed protein C.SFDITYDRVFR.A 2 2.322 0.102 G (91%) product. Homo sapiens cDNA: FLJ23229 fis, IPI:IPI00017947.1 GP:AK026882_1 clone CAE06852; unnamed protein P.LEATKGCTECRATFCNECFKLF.H 2 2.933 0.097 A, G (95%) product. Homo sapiens cDNA: FLJ23471 fis, GP:AK027124_1 clone HSI11969; unnamed protein R.MEPPAPLSTSSTSQASALP.P 1 1.839 0.200 G product. Homo sapiens cDNA: FLJ23581 fis, IPI:IPI00024486.1 GP:AK027234_1 clone LNG13607; unnamed protein L.YGLAERVVATESLVFLAEQ.F 2 2.588 0.182 P (95%) product. Homo sapiens cDNA FLJ14357 fis, clone HEMBA1000005, highly similar to DNAJ GP:AK027263_1 P.DKNKDENAETQFRQLVAIYEVLKDD.E 2 3.072 0.102 A PROTEIN HOMOLOG MTJ1; unnamed protein product. Homo sapiens cDNA FLJ14363 fis, clone GP:AK027269_1 HEMBA1000719; unnamed protein A.YGPLFLRDRVAVGADAFERGD.F 2 2.665 0.226 A product. Homo sapiens cDNA FLJ14374 fis, clone HEMBA1001635, weakly similar to GP:AK027280_1 N.KRKGSDSSIPDEEKMKEEK.Y 2 2.459 0.163 P TESTIS SPECIFIC PROTEIN A; unnamed protein product. Homo sapiens cDNA FLJ14393 fis, clone IPI:IPI00216737.1 GP:AK027299_1 HEMBA1003222; unnamed protein K.ELLSSDMKK.D 1 1.933 0.087 G (99%) product. Homo sapiens cDNA FLJ14454 fis, clone HEMBB1001872, weakly similar to CELL IPI:IPI00064461.1 GP:AK027360_1 E.NGRCICTEEWKGLRCTIANF.C 2 2.553 0.152 O SURFACE GLYCOPROTEIN EMR1 (94%) PRECURSOR; unnamed protein product. Homo sapiens cDNA FLJ14456 fis, clone HEMBB1001915, moderately similar to IPI:IPI00165528.1 GP:AK027362_1 UBIQUITIN CARBOXYL-TERMINAL E.ALHAFIQPEILDGPNQY.F 2 2.748 0.086 O (92%) HYDROLASE 64E (EC 3.1.2.15); unnamed protein product. Homo sapiens cDNA FLJ14463 fis, clone MAMMA1000284, moderately similar to GP:AK027369_1 G.RFGIRRDGPMKFEKDFDF.E 2 2.415 0.150 A P.walti mRNA for rnp associated protein 55; unnamed protein product. Homo sapiens cDNA FLJ14475 fis, clone MAMMA1001259, highly similar to Mus GP:AK027381_1 G.EYFLQAELTSNVLKTGV.V 1 2.096 0.081 G musculus F-box protein FBX18 mRNA; unnamed protein product. Homo sapiens cDNA FLJ14531 fis, clone NT2RM2000371, weakly similar to IPI:IPI00163237.1 GP:AK027437_1 POLYRIBONUCLEOTIDE V.DGVNEPDVLAINGASVALSLS.D 2 2.421 0.181 P (99%) NUCLEOTIDYLTRANSFERASE (EC 2.7.7.8); unnamed protein product. Homo sapiens cDNA FLJ14590 fis, clone NT2RM4001880, weakly similar to IPI:IPI00179949.1 GP:AK027496_1 PUTATIVE DNA HELICASE II D.LYAAGGVNIWALV.A 2 2.422 0.131 A (98%) HOMOLOG (EC 3.6.1.-); unnamed protein product.
Supplementary Table 2 44 Homo sapiens cDNA FLJ14593 fis, clone NT2RM4002073, moderately similar to IPI:IPI00030265.1 GP:AK027499_1 Y.HMSGSLLGIVGCMGIGATVVLKS.K 2 2.513 0.111 O Mus musculus fatty acid transport protein (91%) 3 mRNA; unnamed protein product. Homo sapiens cDNA FLJ14621 fis, clone IPI:IPI00045905.1 GP:AK027527_1 NT2RP2000079; unnamed protein K.CPDQKCLYTCQIKDGGVQPQF.E 2 2.717 0.089 P (91%) product. Homo sapiens cDNA FLJ14624 fis, clone NT2RP2000248, weakly similar to UDP- N-ACETYLGLUCOSAMINE--PEPTIDE IPI:IPI00045901.1 GP:AK027530_1 N- P.SVGYCVLLTFGFGALSKHTKK.K 2 2.377 0.181 P (97%) ACETYLGLUCOSAMINYLTRANSFERA SE 110 KD SUBUNIT (EC 2.4.1.-); unnamed protein product. Homo sapiens cDNA FLJ14627 fis, clone IPI:IPI00180429.1 GP:AK027533_1 NT2RP2000289; unnamed protein H.RGHSEEGGDEQPGTPAPA.L 2 2.416 0.159 A (99%) product. Homo sapiens cDNA FLJ14721 fis, clone GP:AK027627_1 NT2RP3001608; unnamed protein A.VVVTELGPGAARELAGPPADAL.S 2 2.408 0.226 O product. Homo sapiens cDNA FLJ14814 fis, clone NT2RP5003500, highly similar to Mus IPI:IPI00220489.1 GP:AK027720_1 musculus mRNA for heparan sulfate 6- Q.YVCPGTECQLLRLQA.F 2 2.513 0.127 P (94%) sulfotransferase 2; unnamed protein product. Homo sapiens cDNA FLJ14886 fis, clone IPI:IPI00059688.1 GP:AK027792_1 PLACE1003723; unnamed protein H.FMVKLLDDGTF.M 1 2.161 0.082 G (99%) product. Homo sapiens cDNA FLJ14964 fis, clone PLACE4000581, moderately similar to IPI:IPI00178104.1 GP:AK027870_1 V.TWQIPTAKDNSGEKVSVH.V 1 2.288 0.091 G FIBROPELLIN I PRECURSOR; (98%) unnamed protein product. Homo sapiens cDNA FLJ30028 fis, clone GP:AK054590_1 3NB692001288; unnamed protein P.NAVVMGLAPEHFHYQILNQAF.R 2 2.919 0.093 P product. Homo sapiens cDNA FLJ30213 fis, clone BRACE2001673, highly similar to Mus GP:AK054775_1 E.QAFETSQKYKEGKYII.E 1 2.020 0.083 G musculus mdgl-1 mRNA; unnamed protein product. Homo sapiens cDNA FLJ30277 fis, clone GP:AK054839_1 BRACE2002752; unnamed protein H.RAPSPAAPSRPGAPAAGPRKLLVPGL.P 2 2.523 0.153 G product. Homo sapiens cDNA FLJ30329 fis, clone IPI:IPI00102840.1 GP:AK054891_1 BRACE2007201; unnamed protein L.LLMFHCVGSQDSKCHARGLKMLERVR.S 3 3.594 0.206 P (98%) product. Homo sapiens cDNA FLJ30412 fis, clone GP:AK054974_1 BRACE2008653; unnamed protein V.RYTSLPALADDILQLSRRRSE.I 2 2.576 0.139 O product. Homo sapiens cDNA FLJ30449 fis, clone A.SQPLQLQLWLWLKGANVQLGPWLQRVQA IPI:IPI00043780.1 GP:AK055011_1 BRACE2009274; unnamed protein 2 2.502 0.151 A TSLGGF.H (95%) product. Homo sapiens cDNA FLJ30594 fis, clone GP:AK055156_1 BRAWH2008903; unnamed protein A.FVIFPSHHHTPT.R 2 2.466 0.236 G product. Homo sapiens cDNA FLJ30600 fis, clone GP:AK055162_1 BRAWH2009360; unnamed protein I.LEEPNLDKKPSKLKSKSSGNT.S 2 2.441 0.126 A product. Homo sapiens cDNA FLJ30619 fis, clone GP:AK055181_1 CTONG2001533; unnamed protein S.SSHQMLSEIRPQAIEQV.Q 1 2.362 0.102 A product. Homo sapiens cDNA FLJ30638 fis, clone CTONG2002721, weakly similar to IPI:IPI00061078.1 GP:AK055200_1 VACUOLAR PROTEIN SORTING- L.LLDMLAAIAGPENSSKIGLANK.D 2 2.366 0.168 G (95%) ASSOCIATED PROTEIN VPS13; unnamed protein product. Homo sapiens cDNA FLJ30826 fis, clone FEBRA2001715, weakly similar to ZINC- IPI:IPI00026828.1 GP:AK055388_1 F.RSSPHQLSLHSSLQSLNAPGCN.F 2 2.632 0.278 P BINDING PROTEIN A33; unnamed (97%) protein product. Homo sapiens cDNA FLJ30964 fis, clone HEART2000035, weakly similar to IPI:IPI00178183.1 GP:AK055526_1 A.GSRIVLNPNKPVVEW.H 2 2.647 0.205 P Transacylases; unnamed protein (92%) product. Homo sapiens cDNA FLJ31044 fis, clone GP:AK055606_1 HSYRA2000253; unnamed protein L.VQGLILSPRLEYSGTILVDCNL.C 2 2.423 0.115 A product.
Supplementary Table 2 45 Homo sapiens cDNA FLJ31126 fis, clone IMR322000838, highly similar to METHIONYL-TRNA GP:AK055688_1 L.SRLGANMLISVLKNLP.E 2 2.556 0.140 O FORMYLTRANSFERASE, MITOCHONDRIAL PRECURSOR (EC 2.1.2.9); unnamed protein product. Homo sapiens cDNA FLJ31187 fis, clone KIDNE2000349, moderately similar to GP:AK055749_1 Mus musculus putative lysophosphatidic P.QFGDAFWNSSK.Y 1 1.846 0.093 A acid acyltransferase mRNA; unnamed protein product. Homo sapiens cDNA FLJ31197 fis, clone P.RKLSGLGSKQVCSRGCRLGHLAAPGAAC GP:AK055759_1 KIDNE2000519, weakly similar to TONB 2 2.597 0.194 G ML.P PROTEIN; unnamed protein product. Homo sapiens cDNA FLJ31236 fis, clone KIDNE2004828, moderately similar to IPI:IPI00001286.1 GP:AK055798_1 Mus musculus orphan transporter H.VELAIGQRLRKGSVGVWTAISPYL.S 2 2.405 0.141 G (98%) isoform A12 (Xtrp2) mRNA; unnamed protein product. Homo sapiens cDNA FLJ31281 fis, clone KIDNE2006760, weakly similar to GP:AK055843_1 PROSTAGLANDIN F2-ALPHA V.RPGGGPVSVELVG.P 2 2.591 0.120 O RECEPTOR REGULATORY PROTEIN PRECURSOR; unnamed protein product. Homo sapiens cDNA FLJ31330 fis, clone IPI:IPI00169412.1 GP:AK055892_1 MAMGL1000035; unnamed protein L.ESIGGMDGTQQQIFKMLAEVL.G 2 2.752 0.091 P (98%) product. Homo sapiens cDNA FLJ31401 fis, clone IPI:IPI00043428.1 GP:AK055963_1 NT2NE2000038; unnamed protein C.LPQRRGSATPVR.L 2 2.268 0.239 O (95%) product. Homo sapiens cDNA FLJ31425 fis, clone NT2NE2000455, weakly similar to Sdk GP:AK055987_1 A.VNEAGYGEPSNPSTAVSAQVEAPFYE.E 2 2.412 0.166 A (sidekick) protein; unnamed protein product. Homo sapiens cDNA FLJ31438 fis, clone IPI:IPI00184759.1 GP:AK056000_1 NT2NE2000706; unnamed protein M.KKVGIKLLQEINKGGIDAVESLMI.N 2 2.416 0.146 P (99%) product. Homo sapiens cDNA FLJ31479 fis, clone NT2NE2001634, moderately similar to NADH-UBIQUINONE IPI:IPI00008214.2 GP:AK056041_1 R.APRVTVSAKEKTLLQKP.H 1 1.873 0.092 G OXIDOREDUCTASE 9 KD SUBUNIT (96%) PRECURSOR (EC 1.6.5.3); unnamed protein product. Homo sapiens cDNA FLJ31751 fis, clone NT2RI2007439, weakly similar to ZINC GP:AK056313_1 P.HVCGFCGKEFPRSSDLVKHR.R 2 2.252 0.197 A FINGER PROTEIN 84; unnamed protein product. Homo sapiens cDNA FLJ31872 fis, clone NT2RP7002376, weakly similar to M IPI:IPI00166324.1 GP:AK056434_1 Q.YPKFIVDYQTQE.R 2 3.090 0.146 A PROTEIN, SEROTYPE 2.1 (99%) PRECURSOR; unnamed protein product. Homo sapiens cDNA FLJ31937 fis, clone NT2RP7006527, moderately similar to GP:AK056499_1 L.YQLPPHDNEVR.Y 1 1.983 0.089 G LIM-ONLY PROTEIN 6; unnamed protein product. Homo sapiens cDNA FLJ31966 fis, clone NT2RP7007925, weakly similar to Homo IPI:IPI00216285.1 GP:AK056528_1 sapiens contactin associated protein V.GTGGWSPADSNAQQWLQMDLGNRV.E 2 2.571 0.160 P (95%) (Caspr) mRNA; unnamed protein product. Homo sapiens cDNA FLJ31978 fis, clone NT2RP7008406, weakly similar to GP:AK056540_1 I.LEAMDLEVPVLARNIPG.N 2 2.400 0.108 O Probable hexosyltransferase (EC 2.4.1.-) SC2G5.06; unnamed protein product. Homo sapiens cDNA FLJ32079 fis, clone IPI:IPI00102268.1 GP:AK056641_1 OCBBF2000013; unnamed protein L.SRELANLLMQTEGPELEER.Y 2 2.353 0.191 P (95%) product. Homo sapiens cDNA FLJ32151 fis, clone PLACE5000172, highly similar to Homo L.SLAMNTWAQTIFPLGTFPDWADMYSVNVT GP:AK056713_1 sapiens sodium-dependent high-affinity 3 3.507 0.116 G ALPPTLANDTFR.T dicarboxylate transporter (NADC3) mRNA; unnamed protein product. Homo sapiens cDNA FLJ32177 fis, clone GP:AK056739_1 PLACE6001294; unnamed protein R.LSHKSSPPCTYTQ.H 1 1.926 0.168 P product. Homo sapiens cDNA FLJ32203 fis, clone GP:AK056765_1 R.GEAGGGASGGP.Q 1 1.819 0.114 G PLACE6003038, weakly similar to ZINC
Supplementary Table 2 46 FINGER PROTEIN 84; unnamed protein product. Homo sapiens cDNA FLJ32230 fis, clone PLACE6004464, weakly similar to IPI:IPI00065532.1 GP:AK056792_1 D.EEEKAFIPTLHENLDIKV.T 2 2.574 0.125 P Human placenta (Diff48) mRNA; (95%) unnamed protein product. Homo sapiens cDNA FLJ32280 fis, clone GP:AK056842_1 PROST2000176, weakly similar to RD G.PRRDTHRDAGPRAGEHGVWEK.P 2 2.431 0.246 O PROTEIN; unnamed protein product. Homo sapiens cDNA FLJ32384 fis, clone SKMUS1000104, weakly similar to Homo GP:AK056946_1 R.SPRTQSPGGCSAEA.V 1 1.829 0.096 A sapiens mRNA for HEXIM1 protein, complete cds; unnamed protein product. Homo sapiens cDNA FLJ32535 fis, clone SMINT2000277, weakly similar to GP:AK057097_1 L.QLHSIIPSDKGT.Y 1 2.334 0.095 P BUTYROPHILIN PRECURSOR; unnamed protein product. Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo IPI:IPI00065472.1 GP:AK057099_1 L.SDSRITLKSGYGKYLGINSD.E 2 2.693 0.094 A sapiens FRG1 mRNA; unnamed protein (93%) product. Homo sapiens cDNA FLJ32638 fis, clone SYNOV2000820, weakly similar to H.KPGQQHLRGRPCSDDVTPLRLSGRHFPK IPI:IPI00171741.2 GP:AK057200_1 3 3.582 0.155 G Trichoplusia ni transposon IFP2; SIPATSGKQNPTGR.C (93%) unnamed protein product. Homo sapiens cDNA FLJ32647 fis, clone SYNOV2001374, moderately similar to IPI:IPI00069682.2 GP:AK057209_1 K.AEAAAEQSASVEVP.S 2 2.566 0.205 A ZINC FINGER PROTEIN 134; unnamed (95%) protein product. Homo sapiens cDNA FLJ32676 fis, clone TESTI1000168, weakly similar to IPI:IPI00065458.1 GP:AK057238_1 PROTEIN PHOSPHATASES PP1 F.EAKDELCPEKPSGEEPPV.E 1 2.184 0.081 A (95%) REGULATORY SUBUNIT SDS22; unnamed protein product. Homo sapiens cDNA FLJ32706 fis, clone IPI:IPI00168405.1 GP:AK057268_1 TESTI2000627; unnamed protein A.QLFYNITLAFSRTCGR.S 2 2.378 0.121 P (99%) product. Homo sapiens cDNA FLJ32745 fis, clone TESTI2001511, weakly similar to IPI:IPI00065415.1 GP:AK057307_1 T.EQLQWMPFVNIKLHEPFVK.F 2 2.241 0.199 G MYOSIN II HEAVY CHAIN, NON (97%) MUSCLE; unnamed protein product. Homo sapiens cDNA FLJ32764 fis, clone IPI:IPI00177772.1 GP:AK057326_1 TESTI2001829; unnamed protein V.PDLIVIPR.S 1 1.987 0.153 P (95%) product. Homo sapiens cDNA FLJ32800 fis, clone IPI:IPI00065349.1 GP:AK057362_1 TESTI2002544; unnamed protein F.LSEASIALLHDS.F 1 2.043 0.131 G (94%) product. Homo sapiens cDNA FLJ32810 fis, clone TESTI2002729, weakly similar to Homo GP:AK057372_1 G.SVVAAKAQLFENV.G 2 2.499 0.127 P sapiens mRNA for oligophrenin 1; unnamed protein product. Homo sapiens cDNA FLJ32827 fis, clone TESTI2003109, weakly similar to IPI:IPI00221315.1 GP:AK057389_1 D.KIVRRNATMIFGILASNNDV.K 2 2.441 0.142 P VACUOLAR PROTEIN 8; unnamed (92%) protein product. Homo sapiens cDNA FLJ32884 fis, clone GP:AK057446_1 TESTI2004229; unnamed protein K.EEKLGSGQSPTQGTPKKEDA.T 2 2.675 0.219 P product. Homo sapiens cDNA FLJ32938 fis, clone IPI:IPI00184456.1 GP:AK057500_1 TESTI2007613; unnamed protein F.TKETLASQNTKMISSIVISQMIDEN.K 2 2.550 0.170 A (98%) product. Homo sapiens cDNA FLJ32981 fis, clone TESTI3000002, weakly similar to IPI:IPI00152877.1 GP:AK057543_1 L.mexicana lmsap2 gene for secreted A.QPTKICEQHVRWGRFAK.G 2 2.217 0.118 G (98%) acid phosphatase 2 (SAP2); unnamed protein product. Homo sapiens cDNA FLJ33047 fis, clone IPI:IPI00167320.1 GP:AK057609_1 TRACH1000018; unnamed protein L.DLEKSLQFLQQQ.H 2 2.491 0.261 A (99%) product. Homo sapiens cDNA FLJ25042 fis, clone GP:AK057771_1 L.HCQQLFTTYEAVKQLPSNEGC.K 2 2.607 0.097 A CBL03351; unnamed protein product. Homo sapiens cDNA FLJ25287 fis, clone IPI:IPI00153012.1 GP:AK058016_1 G.FGISTKLWGYCFHTLTPEKPHL.K 2 2.427 0.131 O STM06919; unnamed protein product. (96%) Homo sapiens cDNA FLJ25315 fis, clone IPI:IPI00065144.1 GP:AK058044_1 M.TFVQFRRMMAKRPAIKK.A 2 2.459 0.120 P TST00114; unnamed protein product. (93%) GP:AK058059_1 Homo sapiens cDNA FLJ25330 fis, clone E.TLLLSPPVKVKGEDGDREPEGTLPAEA.P 2 2.621 0.121 O, P
Supplementary Table 2 47 TST00576; unnamed protein product. Homo sapiens cDNA FLJ25336 fis, clone IPI:IPI00065115.1 GP:AK058065_1 L.PGTSRAILLYMLYVVCLVFRPG.H 2 2.565 0.161 O TST00709; unnamed protein product. (91%) Homo sapiens cDNA FLJ25416 fis, clone IPI:IPI00217620.1 GP:AK058145_1 L.VSKRSNCPKCGSTGESGNANYRYK.L 2 2.318 0.183 P TST03452; unnamed protein product. (92%) Homo sapiens cDNA FLJ25473 fis, clone GP:AK058202_1 R.GAGFPSIPVGKSPMVE.Q 1 2.132 0.097 G TST09650; unnamed protein product. Human DNA sequence from clone RP1- 148E22 on chromosome 20q12-13.12 Contains the YWHAB gene encoding IPI:IPI00145268.1 GP:AL008725_2 tyrosine 3-monooxygenase/ntryptophan F.GFVHFETHEAAQ.Q 2 2.612 0.195 A (95%) 5-monooxygenase activation protein, beta polypeptide, a novel gene similar to PABPC1 (poly (A)-binding protein, c Human DNA sequence from clone RP3- 337O18 on chromosome 20q12-13.1. Contains the PLPT gene encoding Phospholipid Transfer Protein, the PPGB GP:AL008726_1 A.PQRLLFEVTSANVVKDPPSKYVL.Y 2 2.423 0.103 A gene coding for Lysosomal Protective Protein precursor (EC 3.4.16.5, Cathepsin A, Carboxypeptidase C) and the g Homo sapiens DNA sequence from PAC 845O24 on chromosome 1p36.1-36.2. Contains a gene for a Heterogenous Nuclear Ribonucleoprotein HNRNP C1 N.LEKIEKEQSKQEVEVKNAKSEEEQSSSSM GP:AL022101_4 3 3.588 0.253 O LIKE protein and four genes similar to K.K Melanoma Preferentially Expressed Antigen PRAME and KIAA0014. Contains E Human DNA sequence from clone RP3- 501N12 on chromosome 6p22.1-22.3. Contains the 3' end of a novel gene, the GP:AL022170_2 5' end of the gene for secretagogin R.SSKLYSTIAEEEVNAIGHRK.S 2 2.312 0.115 G (SECRET), a PX19 pseudogene, ESTs, STSs, GSSs and a CpG island, complete sequence; Human DNA sequence from clone RP5- 1042K10 on chromosome 22q13.1-13.2 Contains the ADSL gene for Adenylosuccinate lyase (EC 4.3.2.2, IPI:IPI00026904.1 GP:AL022238_2 A.MVKAGGSRQVQ.R 1 2.110 0.096 P Adenylosuccinase, ASL) and 4 novel (96%) genes (one with probable rabGAP domains and Src homology domain 3). Contains ESTs, Human DNA sequence from clone RP5- 1042K10 on chromosome 22q13.1-13.2 Contains the ADSL gene for Adenylosuccinate lyase (EC 4.3.2.2, IPI:IPI00020761.1 GP:AL022238_4 V.VSRQLPGLLPNTALTPP.T 2 2.462 0.100 P Adenylosuccinase, ASL) and 4 novel (95%) genes (one with probable rabGAP domains and Src homology domain 3). Contains ESTs, Human DNA sequence from clone RP3- 511B24 on chromosome 20q11.2-12 Contains the 3' end of the TOP1 gene for GP:AL022394_4 topoisomerase (DNA) I, the PLCG1 gene D.GYLYSCKYCDFRSHDMTQFV.G 2 2.503 0.143 O for phospholipase C gamma 1, gene KIAA0395 for a possible homeobox protein, a 60S Ribosomal Protein L23A Human DNA sequence from clone 248E1 on chromosome 6q23.1-23.3 Contains DOPAMINE-BETA-MONOOXYGENASE GP:AL023578_1 PRECURSOR, EF-1-ALPHA-2 Q.RGHESLVHHILLY.Q 2 2.456 0.106 P pseudogene EST GSS and CA repeat, complete sequence; match: protein P09172. Human DNA sequence from clone RP1- 153G14 on chromosome 6p21.3-22.2 Contains the 3' end of the ZNF184 gene GP:AL031118_1 for Kruppel-like zinc finger protein 184, a T.EHQRIHSGEKPHECRVCGK.G 2 2.438 0.105 G gene for a possible CA binding protein similar to NEFA, part of a gene for a novel C2H2 type Zinc Fi Human DNA sequence from clone IPI:IPI00027698.1 GP:AL031177_1 889N15 on chromosome Xq22.1-22.3. I.GSLVGAAIIISVVCFAR.N 1 1.882 0.137 A (97%) Contains part of the gene for a novel
Supplementary Table 2 48 protein similar to X. laevis Cortical Thymocyte Marker CTX, the possibly alternatively spliced gene for 26S Proteasome subunit p28 (Ankyrin repeat p Human DNA sequence from clone 462O23 on chromosome 1p35.1-36.12. Contains genes for two novel proteins, GP:AL031431_2 S.VIASAIIGIIFIKEKWKPKDFL.R 2 2.854 0.149 G ESTs, STSs, GSSs and putative CpG island, complete sequence; supported by FGENES and GENSCAN. Human DNA sequence from clone RP5- 1119D9 on chromosome 20p12. Contains the 3' end of the gene for PAK5 IPI:IPI00016848.1 GP:AL031652_2 (KIAA1264) (P21-Rho-binding domain Y.ECQAQQTISLASSDPQKTVTM.I 2 2.469 0.143 A (92%) containing serine/threonine protein kinase), a novel gene similar to bovine glucose induced gene, and the 3' end Human DNA sequence from clone RP1- 50O24 on chromosome 1p35.1-35.3. Contains the 3' end of the gene for a novel protein similar to C. elegans IPI:IPI00183979.1 GP:AL034380_4 Y.LARKLTLAIPIIAAIL.F 2 2.471 0.274 A K07B1.7 (Tr:O01886), the gene for a (91%) novel protein (translation of cDNA NT2RM2001100 (Em:AK001211)), the SFN g Human DNA sequence from clone RP5- 1108D11 on chromosome 20q12-13.11 Contains part of the gene for a novel GP:AL034419_2 protein similar to C. elegans T22C1.7, A.PFEADIDATTTETYMGEWKND.K 2 2.498 0.201 G part of the gene for a novel HMG (high mobility group) box protein similar to KIAA0737, KIAA0808 and TNRC Human DNA sequence from clone 115K14 on chromosome Xq22.3-23 GP:AL034450_1 Contains high mobility group protein 2a, Q.PYITKAADLKEKYEKDVADY.K 2 2.610 0.209 G ESTs, STS, complete sequence; match: mRNA Y10043; match: protein O15347. Human DNA sequence from clone RP5- 1002M8 on chromosome 20p11.21- 11.23. Contains the 3' end of the gene IPI:IPI00182651.1 GP:AL035454_2 for N-terminal acetyltransferase complex W.TRSPCCFAWDFLNSLALVL.V 2 2.530 0.179 O (96%) ard1 subunit, the gene for the ortholog of Drosophila crooked neck (CRN), the 5' end of a novel gene, ESTs Human DNA sequence from clone RP5- 994E9 on chromosome 6p21.31-22.2. Contains the OR12D2, OR11A1, OR10C1 and OR2H1 genes for olfactory IPI:IPI00064656.2 GP:AL035542_3 F.SHLADLQGLLFSVFLTIYLLTVAGN.F 2 2.725 0.085 P receptors 12D2, 11A1, 10C1 and 2H1, (93%) olfactory receptor 12D1 pseudogene OR12D1P, a diubiquitin pseudogene, the MAS-re Human DNA sequence from clone RP3- 475N16 on chromosome 6p12.3-21.2. Contains the genes for CTG4A, pre-T IPI:IPI00151069.2 GP:AL035587_3 cell receptor alpha, a novel protein I.ARLRLKKIFSGVFVKVT.P 1 2.157 0.180 A (94%) similar to RPL7A (60S ribosomal protein L7A) and the 3' end of gene KIAA0240. Contains ESTs, STSs, GSSs and f Human DNA sequence from clone RP5- 890O15 on chromosome 20. Contains the 3' end of the EYA2 gene for eyes IPI:IPI00216796.1 GP:AL049540_1 absent (Drosophila) homolog 2, an RPS2 L.KALNLINSRQNCVNVLVT.T 1 2.132 0.157 O (99%) (40S ribosomal protein S2) pseudogene, the 3' end of the PRKCBP1 gene for protein kinase C binding protein Human DNA sequence from clone RP3- 402N21 on chromosome 6p21.1-21.31. Contains up to three novel genes with MAM and immunoglobulin domains. GP:AL049553_3 V.KEDNISER.V 1 1.964 0.107 G Contains ESTs, STSs, GSSs and four putative CpG islands, complete sequence; this gene fragment and fragments .2 Human DNA sequence from clone IPI:IPI00176482.1 GP:AL049575_1 Y.WVITVLQGVDNSLVGLHNQSFARVM.E 2 2.496 0.136 P 316D7 on chromosome 11p13. Contains (95%)
Supplementary Table 2 49 part of the gene for G2 protein, ESTs, STSs and GSSs; translation differs from Tr:Q12914 owing to frameshifts at around 72443, 72389 and 74560 match: cDNAs: Em:U10991 match: proteins: Homo sapiens mRNA; cDNA DKFZp586A1123 (from clone GP:AL050181_1 K.VPPGSRATFQVE.H 2 2.594 0.085 O DKFZp586A1123); partial cds; Homo sapiens mRNA for KIAA0518 protein. Homo sapiens mRNA; cDNA DKFZp586G1219 (from clone R.FHDYKAASMHCQELMATGYPKSWDVCS IPI:IPI00179604.1 GP:AL050281_1 3 3.623 0.108 O DKFZp586G1219); partial cds; QL.G (93%) neuroblastoma-amplified protein. Human DNA sequence from clone RP5- 977B1 on chromosome 20 Contains ESTs, STSs, GSSs and three putative CpG islands. Contains the 3' end of the GP:AL050318_3 L.HDMLASLGFIHEDHLRE.L 2 2.401 0.173 P gene for a novel protein tyrosine kinase, a heterogeneous nuclear ribonucleoprotein A3 pseudogene, the gene Human DNA sequence from clone RP4- 570F3 on chromosome 6. Contains the 5' end of the gene for the ortholog of the rat GP:AL050332_1 synaptic ras GTPase-activating protein Q.ILPRFRSADHDRA.R 2 2.859 0.089 P p135 SynGAP, gene LOC51596 for divalent cation tolerant protein CUTA or brain acetylcholineste Human DNA sequence from clone RP4- 570F3 on chromosome 6. Contains the 5' end of the gene for the ortholog of the rat GP:AL050332_5 synaptic ras GTPase-activating protein V.CIFAYGQTGSGKTFTMEGGPG.G 2 2.636 0.183 O p135 SynGAP, gene LOC51596 for divalent cation tolerant protein CUTA or brain acetylcholineste Human DNA sequence from clone RP1- 39G22 on chromosome 1p32.1-34.3. Contains the 3' part of the RLF gene for GP:AL050341_4 rearranged L-myc fusion sequence (ZN- R.EALGAVGMMGPPGPPGPPGYPGKQ.G 2 2.667 0.101 G 15 related zinc finger protein), a novel gene, the ZMPSTE24 gene for yeast zinc metalloproteinase STE24 h Human DNA sequence from clone RP4- 553F4 on chromosome 20q11.21-13.13 Contains the gene for peroxisomal GP:AL050349_2 membrane protein PMP 24, a 3' end of a S.FSRRAHLAEHQRAHTGNYK.F 2 2.303 0.196 G novel gene, part of a novel zinc-finger protein gene, a novel gene encoding a protein similar to the Drosoph Homo sapiens mRNA; cDNA DKFZp564M1916 (from clone GP:AL050358_1 T.PDQLFVSVQDAAAYALGSL.V 2 2.431 0.113 P DKFZp564M1916); partial cds; similarity to pendrin, unspliced. Homo sapiens mRNA; cDNA DKFZp564A026 (from clone IPI:IPI00000265.1 GP:AL050367_1 D.SVYRKVLPALVIPAHY.M 2 2.905 0.122 G DKFZp564A026); unknown; The frame (94%) shift was determined manually. Homo sapiens mRNA; cDNA DKFZp566J153 (from clone IPI:IPI00103476.1 GP:AL050369_1 A.YQEDLGFSLGHLGKSGSGRVR.Q 2 2.463 0.159 O DKFZp566J153); complete cds; similarity (91%) to yeast splicing protein PRP31. Human DNA sequence from clone RP5- 1049G11 on chromosome 20p11.1- 11.23. Contains the gene for a novel IPI:IPI00031471.1 GP:AL078634_2 protein similar to KIAA0884, the 5' part of S.FTSAMSRGCVTEEENTNVKAGV.Q 2 2.570 0.136 G (97%) the gene for a novel protein similar to IF4E-like protein (mRNA cap binding protein 4EHP), ESTs, STSs and Homo sapiens mRNA full length insert IPI:IPI00217413.1 GP:AL079292_1 L.EEEEEVTINVTSKAGGIKKY.Q 2 2.589 0.229 O, P cDNA clone EUROIMAGE 48814. (97%) Human DNA sequence from clone RP5- 1129A6 on chromosome Xp22.11-22.2 Contains part of the gene for SCML2 IPI:IPI00177417.1 GP:AL096763_1 P.VNVVLRRIVQACVDCALETK.T 2 2.421 0.192 O (sex comb on midleg (Drosophila)-like 2) (95%) a GSS and a CpG Island.n, complete sequence. GP:AL096767_1 Human DNA sequence from clone I.AAILSHA.A 1 2.045 0.145 A
Supplementary Table 2 50 579N16 on chromosome 22. Contains the 3' part of the gene for KIAA0685, the SBF1 gene for SET binding factor 1, a novel gene, ESTs, an STS, GSSs and three putative CpG islands, complete sequence; match: proteins: Tr:O751 Novel human mRNA from chromosome IPI:IPI00148247.1 GP:AL096857_1 Q.EKECELEKE.R 2 3.416 0.101 O 1, which has similarities to BAT2 genes. (94%) Arabidopsis thaliana DNA chromosome 3, BAC clone T6H20; EST GB:Z26060 K.GTPFAEICELTDVPEGLIVRTIVRLDETCRE GP:AL096859_1 marks 3'end similarity to helicase SKI2W 3 3.610 0.089 A FK.N - human, PIR2:S56752 contains EST gb:Z26060. Human DNA sequence from clone RP5- 1033H22 on chromosome 1p21.2-22.2 Contains part of a novel gene D.SQLCPKPPPKPCKVPFLKVPSSPSAWLNS IPI:IPI00179053.1 GP:AL109613_2 (KIAA0554), the BCAR3 (breast cancer 3 3.876 0.147 O EA.N (95%) anti-estrogen resistance 3) gene, ESTs, STSs and GSSs, complete sequence; match: proteins: Tr:O75815. Human DNA sequence from clone RP5- 1024N4 on chromosome 1p32.1-33. Contains the gene for a novel Sodium:solute symporter family member GP:AL109659_2 G.LLRMILEFSYPAPACGEVDR.R 2 2.297 0.147 O similar to SLC5A1 (SGLT1), a pseudogene similar to part of butyrophilin family members, a novel gene, ESTs, STSs, GS Human DNA sequence from clone RP5- 834A16 on chromosome X Contains part of a gene similar to PGAM and a CpG Island, complete sequence; match: GP:AL109854_1 I.EAHDNSLTGIIK.H 1 1.871 0.127 G proteins: Sw:P25113 Sw:P07738 Sw:P44865 Sw:P18669 Tr:O51602 Sw:P00950 Sw:P16290 Sw:P15327 Tr:Q9X9S2 Sw:O70250 Human DNA sequence from clone RP3- 383J4 on chromosome 1q24.1-24.3 Contains part of a gene encoding a kelch IPI:IPI00100460.1 GP:AL109921_3 motif containing protein, part of a novel A.CKKLPFEIKNFVK.K 2 2.238 0.107 G (98%) gene encoding a protein similar to Aspartyl-TRNA synthetase, a putative novel gene, a 40S ribosomal p Human DNA sequence from clone RP4- 551D2 on chromosome 20q13.2-13.33 Contains the gene for a cadherin-like IPI:IPI00219288.1 GP:AL109928_3 protein VR20, a novel gene, the PPP1R6 E.FNITVQENQSAGQP.I 2 3.119 0.154 G, O (97%) gene for protein phosphatase 1 regulatory subunit 6, the 5' end of the SYCP2 gene for synaptonemal comple Human DNA sequence from clone RP4- 794I6 on chromosome 20 Contains a putative oncogene (HLC14-06-P), the 3' R.ARSLPLAAAGQGFLRKTWISEHENSPTMS GP:AL109976_2 end of a novel gene, the gene for a novel 3 3.569 0.099 O QNGYFE.D protein similar to solute carrier family 4 anion exchanger 1 (SLC4A1), ESTs, STSs, GSSs and CpG islan Human DNA sequence from clone RP3- 324O17 on chromosome 20 Contains the 5' end of the ID1 gene (Inhibitor of DNA GP:AL110115_3 binding 1, dominant negative helix-loop- E.VVRCLSEQSVAISRCAGGAGARL.P 2 2.436 0.113 P helix protein), a putative novel gene, the 3' end of a novel gene encoding two isoforms (isoform 2 Novel human gene mapping to IPI:IPI00181793.1 GP:AL117234_1 chomosome X, isoform of dbl (proto- L.DRRLDTWSSLKISLQKIS.A 2 2.706 0.084 P (95%) oncogene). Homo sapiens mRNA; cDNA DKFZp434P211 (from clone GP:AL117401_1 DKFZp434P211); complete cds; strong S.EDRPQAVSSGHTQCEKA.A 1 2.455 0.101 A similarity to POM121-like 1 (Homo sapiens). Human DNA sequence from clone RP11- 371L19 on chromosome 20. Contains IPI:IPI00012749.3 GP:AL118502_1 two novel genes, the gene for a novel W.YLPSYLTVVIQLANIGPLLVTLL.H 2 2.911 0.190 A (91%) protein similar to 40S ribosomal protein S10 (RPS10), ESTs, STSs, GSSs and
Supplementary Table 2 51 five CpG islands, complete sequence; match: proteins: Tr:Q9NWF4 Wp:Y Human DNA sequence from clone RP4- 591C20 on chromosome 20 Contains ESTs, STSs, GSSs and CpG islands. GP:AL118506_9 Contains a novel gene for a protein H.DSRSQRAASSRPIKLLQQPGTDTPQGR.L 2 2.271 0.145 O similar to mouse NG26, the TPD52L2 gene for three isoforms of tumor protein D52-like protein 2, a gene for a nove Human DNA sequence from clone RP4- 697K14 on chromosome 20 Contains ESTs, STSs, GSSs and 13 CpG islands. IPI:IPI00024884.1 GP:AL121829_6 Contains a gene for a novel tyrosine E.PDHGTPGSLDPNTDPVPTLPA.E 2 2.804 0.197 A (97%) kinase, the PTK6 gene for a tyrosine kinase, a novel gene, the EEF1A2 gene for eukaryotic translation elongat Human DNA sequence from clone RP5- 908M14 on chromosome 20 Contains the RPS21 (ribosomal protein S21) gene, parts of 4 novel genes, ESTs, STSs, GP:AL121832_5 T.HEAPKLSPKVDRLCLLNR.P 2 2.378 0.166 G GSSs and four CpG islands, complete sequence; match: ESTs: Em:BE731551 Em:BE902358 Em:BE903566 Em:BE902738 Human DNA sequence from clone RP4- 583P15 on chromosome 20 Contains ESTs, STSs, GSSs and ten CpG islands. GP:AL121845_10 Contains the TNFRSF6B gene for tumor H.GVCTDCAGR.G 1 1.803 0.154 P necrosis factor receptor 6b (decoy), the 3' part of the KIAA1088 gene, the ARFRP1 gene for ADP-ribosylation Human DNA sequence from clone RP1- 223E3 on chromosome 6q13-15 Contains the gene for a putative secreted protein ZSIG13, ESTs and GSSs, GP:AL121939_1 K.GSKKLRVGL.L 1 2.014 0.089 A complete sequence; match: cDNAs: Em:AF193611 Em:AF015287 match: ESTs: Em:AA445948 Em:AA453213 Em:AA424003 match: pr Human DNA sequence from clone RP4- 530I15 on chromosome 20 Contains the 3' end of the PTPN1 gene for protein IPI:IPI00099937.1 GP:AL133230_3 tyrosine phosphatase, non-receptor type W.ADILASP.L 1 2.147 0.107 A (98%) 1 (EC 3.1.3.48), the gene for a novel protein similar to placental protein DIFF40, an RPL36 (60S ribos Human DNA sequence from clone RP11- 541N10 on chromosome 10. Contains a novel gene and the 5' end of the gene for IPI:IPI00017143.1 GP:AL133355_1 a novel protein (ortholog of mouse FISH P.NHMEKGCHFLHIL.A 2 2.470 0.116 P (94%) protein), ESTs, STSs, GSSs and two putative CpG islands, complete sequence; supported by FGENESH Human DNA sequence from clone RP1- 71N10 on chromosome 6. Contains the 5' end of a novel gene, ESTs, STSs, GSSs and a putative CpG island, IPI:IPI00165004.1 GP:AL133544_1 D.EIKNNSEVQNQE.C 2 3.019 0.101 O complete sequence; exon 6 and end of (99%) exon 5 and start of exon 7 are derived from FGENESH and GENSCAN predictions Human DNA sequence from clone RP11- 448E12 on chromosome Xq22.1-23. Contains part of the COL4A6 gene for collagen type IV alpha 6, ESTs, STSs V.GPAGPPGLQGPPGPPGPLGPDGNMGLG GP:AL136080_1 2 2.749 0.354 O and GSSs, complete sequence; match: FQ.G cDNAs: Em:D21337 Em:U04845 Em:L22763 match: ESTs: Em:AI889772 Em:AW082083 Human DNA sequence from clone RP3- 417I1 on chromosome 6 Contains the start of a gene for BAG-family molecular IPI:IPI00000725.1 GP:AL136311_1 chaperone regulator 2, part of a novel A.EKFILR.G 1 1.902 0.164 P (98%) gene (KIAA0576), ESTs, STSs, GSSs and a CpG island, complete sequence; match: proteins: Tr:Q9Y4E5. GP:AL136557_1 Homo sapiens mRNA; cDNA L.GLQTLLSLKCCIDLEHGVLRLK.A 2 2.383 0.125 P
Supplementary Table 2 52 DKFZp761G1913 (from clone DKFZp761G1913); unknown protein. Homo sapiens mRNA; cDNA DKFZp761D221 (from clone GP:AL136561_1 DKFZp761D221); complete cds; E.GSTLSGCDIELVGAGYRFSLIK.K 3 3.606 0.096 O similarity to antennal specific membrane protein AMP (Manduca sexta). Homo sapiens mRNA; cDNA DKFZp761M0423 (from clone IPI:IPI00166909.1 GP:AL136576_1 DKFZp761M0423); complete cds; F.PEEPEISE.E 1 2.035 0.098 A (92%) similarity to CaM-kinase kinase alpha (Rattus norvegicus). Homo sapiens mRNA; cDNA DKFZp564F2122 (from clone IPI:IPI00185843.1 GP:AL136604_1 S.LFNTLQEPSGEPQIEDDMLK.E 2 2.317 0.138 P DKFZp564F2122); complete cds; weak (98%) similarity to C.elegans C18C4.5. Homo sapiens mRNA; cDNA DKFZp564N1623 (from clone IPI:IPI00218481.1 GP:AL136618_1 DKFZp564N1623); complete cds; G.SLGHVESGLEDVLGDTDR.G 2 2.468 0.141 O (95%) similarity to putative phosphatidylinositol- 4-phosphate 5-kinase. Homo sapiens mRNA; cDNA DKFZp564O0523 (from clone IPI:IPI00217901.1 GP:AL136619_1 C.KAALNTSAGNSNPYLPYSCELPLCY.F 2 2.527 0.131 A DKFZp564O0523); complete cds; (95%) unknown protein. Homo sapiens mRNA; cDNA DKFZp566A1524 (from clone GP:AL136704_1 V.GVIILYDHVHPVGAFCKT.S 2 2.641 0.125 A DKFZp566A1524); complete cds; similarity to C. elegans R07G3.8. Homo sapiens mRNA; cDNA DKFZp434O0710 (from clone R.SSSGSPRNRAPCRTSTADRPRLADLPSIR GP:AL136736_1 2 2.240 0.147 O DKFZp434O0710); complete cds; FLCK.Q putative protein. Homo sapiens mRNA; cDNA DKFZp434J0113 (from clone F.SPLPPSPMAMIRDSGAIAAGHQPLSTMTV IPI:IPI00217802.1 GP:AL136748_1 3 3.758 0.116 P DKFZp434J0113); complete cds; RS.R (94%) unknown protein. Homo sapiens mRNA; cDNA DKFZp434A1315 (from clone IPI:IPI00183010.1 GP:AL136755_1 R.IVLHHFDSSSQESVPK.R 2 2.286 0.129 G DKFZp434A1315); complete cds; (98%) similarity to S.cerevisiae Hop1. Homo sapiens mRNA; cDNA DKFZp434I0515 (from clone GP:AL136761_1 E.EGGAGRDSYEENPDFEGIPV.L 2 2.702 0.087 G DKFZp434I0515); complete cds; strong similarity to 'radial spokehead' proteins. Homo sapiens mRNA; cDNA DKFZp434N1415 (from clone IPI:IPI00185519.1 GP:AL136765_1 DKFZp434N1415); complete cds; E.KKQLGIKDKEDKKGAKLLGK.E 2 2.214 0.121 P (94%) similarity to neurofilament triplet M protein - rat. Homo sapiens mRNA; cDNA DKFZp434F1017 (from clone GP:AL136775_1 Q.TPEDEALVENVSTEFQSPQVAGIPA.V 2 2.852 0.128 G DKFZp434F1017); complete cds; similarity to neurofilament proteins. Homo sapiens mRNA; cDNA DKFZp434A171 (from clone IPI:IPI00219325.1 GP:AL136793_1 DKFZp434A171); complete cds; K.KASSHAVDRLR.R 2 2.482 0.166 O (94%) similarity to KIAA0565 and ankyrin repeat containing proteins. Homo sapiens mRNA; cDNA DKFZp434N031 (from clone IPI:IPI00165004.1 GP:AL136797_1 E.KSPAPQKQSINKNKSQDF.R 2 2.531 0.102 A DKFZp434N031); complete cds; (98%) similarity to rab11 binding protein. Homo sapiens mRNA; cDNA DKFZp434D0727 (from clone GP:AL136826_1 L.PGRAAAGLPLAPRPLLGALVPLLAL.L 2 2.631 0.101 A DKFZp434D0727); complete cds; putative protein. Homo sapiens mRNA; cDNA DKFZp434D105 (from clone IPI:IPI00152944.1 GP:AL136875_1 W.VISGFGSQNTEIE.S 2 2.665 0.184 G DKFZp434D105); complete cds; putative (96%) protein. Homo sapiens mRNA; cDNA DKFZp434K229 (from clone IPI:IPI00003035.1 GP:AL136908_1 C.NKIEDHFIDLPRKKISNFTNK.N 2 2.306 0.111 A DKFZp434K229); complete cds; (96%) similarity to C-terminus of katanin p80. Homo sapiens mRNA; cDNA GP:AL136920_1 T.GSVLEDAWKEKGKMDMEE.I 2 3.053 0.138 G DKFZp586C051 (from clone
Supplementary Table 2 53 DKFZp586C051); complete cds; PAIP1. Human DNA sequence from clone RP11- 130C19 on chromosome 9p24.1-24.3 Contains a translation initiation factor IPI:IPI00183751.1 GP:AL136979_1 SUI1 pseudogene and the 3' end of the G.DYIAAFEAISPDVLRYVINL.A 2 2.489 0.248 A (94%) gene for KIAA0172 protein, complete sequence; match: proteins: Tr:Q9Z1P7 Tr:Q14678 Tr:Q9V777 Tr:Q9N5D9 Homo sapiens mRNA; cDNA DKFZp761A179 (from clone GP:AL137451_1 V.EPPTDLNVTEGMAAELK.C 2 2.214 0.141 G DKFZp761A179); partial cds; similarity to Drosophila slit protein 2. Novel human gene mapping to GP:AL137762_1 S.PGLKAMVSPFHSPPSTPSSPGVRS.R 2 3.104 0.184 O chomosome 1. Human DNA sequence from clone RP11- 430M15 on chromosome 13. Contains the 3' end of the gene for a novel protein IPI:IPI00178349.1 GP:AL138707_1 (ortholog of rat four repeat ion channel), I.IAYIMLNLL.V 1 2.045 0.091 O (91%) ESTs, STSs and GSSs, complete sequence; continued from bA44I7.1 in Em:AL354891 match: proteins: Human DNA sequence from clone RP11- 500G10 on chromosome 10. Contains the gene for a thioredoxin-like protein, GP:AL139123_2 the gene for a novel protein similar to P.PPRPGFFPR.P 2 2.392 0.100 G, O meningioma expressed antigen 6 (MEA6) and 11 (MEA11), a novel gene, ESTs, STSs, GSSs and four CpG is Human DNA sequence from clone RP11- 76N11 on chromosome 13 Contains the 5' end of the DACH gene (Dachshund V.TSTGGGGGGGGGGSGGGGGSSGNGGG GP:AL139186_1 (Drosophila) homolog), a 60S ribosomal 2 2.711 0.125 G GGGGGGGSN.C protein L35A pseudogene, a CpG island, ESTs, STSs and GSSs, complete sequence; match: proteins: Tr:Q9QYB2 Human DNA sequence from clone RP5- 1078M7 on chromosome 1p32.1-32.3 Contains part of the gene for KIAA0172 protein, ESTs, STSs, GSSs and a CpG IPI:IPI00168163.1 GP:AL139343_1 G.YTAVMITPLASAETNEDMAVV.W 2 2.421 0.112 O island, complete sequence; match: (98%) cDNAs: Em:AF070591 Em:D79994 match: ESTs: Em:AW409800 Em:AA358454 match: p Human DNA sequence from clone RP11- 110H4 on chromosome 5 Contains a pseudogene similar to GUSB (glucuronidase, beta), a gene for a GP:AL157879_1 Q.TLAPRGGSPRSQASRPRI.N 1 2.252 0.098 G membrane protein, ESTs, STSs, GSSs and CpG islands, complete sequence; match: cDNAs: Em:AL117401 Em:AB014518 Em:U21556 Novel human mRNA from chromosome 1, clones AL031286, AL022400, IPI:IPI00148250.1 GP:AL157958_1 AL022171, has similarities to mouse Hh1 T.LVKSGVPEALRAEVW.Q 1 2.020 0.089 A (97%) mRNA (af118565) and human rab6 GTPase activating protein. Human DNA sequence from clone RP11- 268F1 on chromosome 6 Contains ESTs, STSs, GSSs and a CpG island. Contains the MEP1A gene for meprin A alpha IPI:IPI00004372.1 GP:AL161618_1 Y.TGERCQAVQVHGSVLGMVIGGTAGVIFL.T 2 2.617 0.259 O (PABA peptide hydrolase), complete (95%) sequence; match: cDNAs: Em:M82962 Em:M74897 Em:S43408 Em:X81333 Em:M886 Human DNA sequence from clone RP5- 1187J4 on chromosome 20q11.1-11.23 Contains ESTs, STSs, GSSs and two GP:AL355392_3 CpG islands. Contains the gene for novel L.LSELTGAVSGLLPQGTEGL.V 2 2.688 0.117 G, P protein similar to mouse von Ebner salivary gland protein, the gene for a novel protein similar to rat RYF Human DNA sequence from clone RP5- 1187J4 on chromosome 20q11.1-11.23 Contains ESTs, STSs, GSSs and two GP:AL355392_4 T.VPGSSLSSDTKNVSVSLILSYA.M 2 2.582 0.256 O CpG islands. Contains the gene for novel protein similar to mouse von Ebner salivary gland protein, the gene for a
Supplementary Table 2 54 novel protein similar to rat RYF Human DNA sequence from clone RP13- 206I21 on chromosome Xp11.3-21.1 Contains part of the ATP11C gene for ATPase, Class VI, type 11C, complete IPI:IPI00103413.1 GP:AL356785_1 I.FLVQVTVDTPTSPVTSGLPLFFVITVT.A 2 2.625 0.115 A sequence; match: cDNAs: Em:AF156551 (93%) Em:AF236061 Em:AB028944 Em:AB023173 Em:AL161996 match: ESTs: Em:AW162137 Human DNA sequence from clone RP11- 353C18 on chromosome 20 Contains ESTs, STSs, GSSs and CpG islands. IPI:IPI00001961.1 GP:AL357374_1 Contains the NIFS gene for cysteine V.PADTAAAPEV.G 1 2.040 0.136 A (99%) desulfurase, two genes for novel proteins and the CC1.3 gene for the splicing factor CC1.3 with a second isoform Mouse DNA sequence from clone RP21- 417G6 on chromosome 5. Contains the 3' end of the Brca2 gene for early onset GP:AL358892_3 breast cancer protein 2, three novel W.EMKPYAVMEFQTEQKH.L 2 2.418 0.109 A genes, the 5' end of the gene for a novel protein (ortholog of human androgen- induced prostrate proli Human DNA sequence from clone RP11- 550O8 on chromosome 20. Contains a novel gene encoding a protein kinase, an GP:AL359916_1 RPL7 (60S Ribosomal Protein L7) A.EIGRGSYGVVYEAVAGRSGA.R 2 2.423 0.106 P pseudogene, a CpG island, ESTs, STSs and GSSs, complete sequence; match: proteins: Tr:O04290 Tr:Q9SIQ7 Tr:Q Arabidopsis thaliana DNA chromosome 3, BAC clone F28D10; similarity to serine kinase SRPK2, Homo sapiens, GP:AL391254_4 EMBL:AC005070 Contains EGF-like I.CFELATGDVLFDPHSG.E 1 2.001 0.120 P domain signatures AA319-330;Protein kinases signatures and profile AA51- 74;Protein kinases signatures and profil Human DNA sequence from clone RP11- 342L8 on chromosome 6 Contains a gene for a novel protein similar to GP:AL391840_1 C21ORF13, a putative novel gene, V.GFRSQSLNREPLRKDTDLV.T 2 2.483 0.119 P ESTs, STSs, GSSs and a CpG island, complete sequence; match: proteins: Sw:O95447. Human DNA sequence from clone RP13- 379O24 on chromosome 20 Contains a gene for a novel protein similar to transcription factor GATA-5, ESTs, GP:AL499627_1 A.PGHLEFKFEPEDFAF.P 2 2.515 0.143 A STSs, GSSs and two CpG islands, complete sequence; match: proteins: Tr:Q16365 Sw:P43692 Wp:F52C12 Tr:Q9TXV3 S Homo sapiens mRNA; cDNA DKFZp761D171 (from clone GP:AL512764_1 F.GCTVGLKDSVNAVVFVALGTSIPGNT.L 2 2.483 0.149 A DKFZp761D171); Na+/Ca2+-exchanging protein Nac2. Neurospora crassa DNA linkage group V Cosmid contig 3H10; similarity to nuclear GP:AL513442_5 L.METTDNTATSSPT.P 1 2.289 0.080 G protein SA-1, Homo sapiens, TREMBL:HSSA1_. Neurospora crassa DNA linkage group V Cosmid contig 17E5; similarity to HFB30 (protein with a RING finger motif), Homo sapiens, TREMBL:AB022663_1 Contains GP:AL513467_20 A.GRGRGGGAAGGAAAAA.P 1 2.059 0.197 G pfkB family of carbohydrate kinases signatures [GGPLNGTDRVGGAGSAEGAGAGAG]; Zinc finger, C3HC4 ty Homo sapiens genomic DNA, GP:AP000504_6 chromosome 6p21.3, HLA Class I region, L.LAALLHSVAPLLR.A 2 2.498 0.104 P section 3/20; Partial coding region. Homo sapiens genomic DNA, chromosome 6p21.3, HLA Class I region, IPI:IPI00183005.1 GP:AP000507_1 F.LLLAGIFPFAPPGAAAEPHSLRYN.L 2 2.418 0.239 A section 6/20; alternative name: (99%) PERB11.1. Sequence 6 from Patent WO0145730; IPI:IPI00004608.1 GP:AX180719_1 A.PCSRGSSWSADLDKCMDC.A 2 2.833 0.098 G human TWEAK receptor fusion protein (96%)
Supplementary Table 2 55 construct. Sequence 1 from Patent WO0168704; GP:AX253146_1 human breast cancer amplified G-protein V.IKLSCADTAMNDTIL.A 1 2.290 0.093 P coupled receptor 1 (BCA-GPCR-1). Synthetic construct clone D12 anti- human C3a receptor single-chain GP:AY008757_1 C.LQYASSPPTFGGGTKL.E 1 2.106 0.125 A variable fragment antibody light chain mRNA, partial cds. Homo sapiens PRTD-NY2 mRNA, complete cds; testis development- IPI:IPI00186433.1 GP:AY009106_1 related; higher expression level in adult C.DETVIQKKITTIINCFINSSIPPA.L 2 2.416 0.143 G (99%) testis as compared to 6-week-old fetal testis. Homo sapiens ASC-1 complex subunit IPI:IPI00171015.1 GP:AY013288_1 P200 mRNA, partial cds; putative RNA I.VKELTGDMQLSKSEILRTQMLV.T 2 2.406 0.287 P (98%) helicase; DEVH family. Homo sapiens FKSG29 (FKSG29) GP:AY014273_1 I.YHNTNLGIKLSIRHFCKIS.I 2 2.476 0.186 G mRNA, complete cds. Homo sapiens ATP-binding cassette A9 IPI:IPI00183538.1 GP:AY028899_1 V.RDFDETPVIIASCLRKEYAGKKK.N 2 2.222 0.226 A mRNA, complete cds; ABC-A9. (99%) Homo sapiens protocadherin 15 IPI:IPI00184519.1 GP:AY029205_1 R.YILIITA.S 1 1.807 0.093 P (PCDH15) mRNA, complete cds. (96%) Homo sapiens CARD-containing MAGUK 2 protein (CARMA2) mRNA, complete cds; contains caspase recruitment IPI:IPI00012213.1 GP:AY032927_1 domain CARD, coiled coil, PDZ, SH3, Y.EASEPL.F 1 2.121 0.090 A, O (92%) guanylate kinase domain GUK; interacts with the CARD-containing molecule Bcl10 (CARMEN). Homo sapiens nGAP-like protein GP:AY032952_1 (AF9q34) mRNA, complete cds; MLL K.DFLTDLMMSEVDR.C 2 2.345 0.163 O fusion partner. Homo sapiens clone case1-07 GP:AY033244_1 immunoglobulin heavy chain variable -.QVQLQQSGPGLVT.P 2 3.566 0.133 G region mRNA, partial cds; IGHV. Homo sapiens clone case2-06 GP:AY033256_1 immunoglobulin heavy chain variable -.EVQLVQSGGNLVQPGGSLR.L 2 2.389 0.126 O region mRNA, partial cds; IGHV. Homo sapiens clone case2-14 GP:AY033264_1 immunoglobulin heavy chain variable -.EVQLVQSGAEVQ.K 2 3.954 0.238 G, O, P region mRNA, partial cds; IGHV. Homo sapiens clone case3-11 IPI:IPI00018563.3 GP:AY033281_1 immunoglobulin heavy chain variable -.EVQLVQSGAEVKKPGESLQ.I 2 4.621 1.000 P (97%) region mRNA, partial cds; IGHV. Homo sapiens ubiquitin-like protein GP:AY037166_1 V.PDPELIDLIYCGRKLKDDQ.T 2 2.590 0.138 A SB132 mRNA, complete cds. Homo sapiens aristaless-related GP:AY038071_1 homeobox protein ARX mRNA, partial S.GALADPATAAADRR.A 2 2.313 0.120 P cds. Homo sapiens ATP-binding cassette transporter sub-family C member 12 IPI:IPI00152887.1 GP:AY040220_1 T.SGKVWVGIGLCIALFATEFTKVF.F 2 2.434 0.275 P (ABCC12) mRNA, complete cds; (96%) CFTR/MRP. Homo sapiens Fc receptor-like protein 1 IPI:IPI00186942.1 GP:AY043464_1 (FCRH1) mRNA, complete cds; Ig-like Y.SLAYYNQPEQESVAAETLG.T 2 2.519 0.165 G (97%) superfamily receptor. Homo sapiens sorting nexin 14 (SNX14) IPI:IPI00216696.1 GP:AY044865_1 mRNA, complete cds; contains PX K.FAEPRNKKPSVLKLELKQIREQQDL.L 3 3.562 0.127 P (96%) domain. Homo sapiens BRMS2 mRNA, complete IPI:IPI00019488.1 GP:AY050497_1 A.QHLQAAVAFVEQ.G 2 2.489 0.129 A cds. (93%) Homo sapiens clone WR10VL GP:AY050691_1 immunoglobulin light chain variable Y.GSSTTHVIFGGGTK.V 2 2.462 0.171 G region mRNA, partial cds. Trichechus manatus von Willebrand GP:AY057835_1 factor (vWF) gene, partial cds; similar to E.ASRIALLLTASQEPPRMARNLVR.Y 2 2.385 0.100 G Homo sapiens VWF exon 28. Mus musculus anti-human CD37 antibody WR17 gamma heavy chain GP:AY058909_1 V.QLQESGPELVKPGASVKV.S 1 2.162 0.093 A variable region mRNA, complete cds; WR17 VH. Homo sapiens, clone IMAGE:3507673, GP:BC000040_1 T.DLHCGFGGPLARVATSSLDQTVK.L 2 2.306 0.116 G mRNA, partial cds. Homo sapiens, clone MGC:3121 GP:BC000119_1 L.ELPSTPPPSSLLRPR.L 2 2.251 0.242 P IMAGE:3351963, mRNA, complete cds. GP:BC000121_1 Homo sapiens, clone MGC:3130 P.VSSIGSPVGTPKGPQGALQT.P 2 3.164 0.210 G, P IPI:IPI00177824.1
Supplementary Table 2 56 IMAGE:3352851, mRNA, complete cds. (94%) Homo sapiens, clone IMAGE:3351405, IPI:IPI00031554.1 GP:BC000210_1 R.GQLRYVEQ.K 1 1.865 0.092 P mRNA, partial cds. (95%) Homo sapiens, Similar to hepatoma- derived growth factor, related protein 2, GP:BC000755_1 G.SGGSSGDELREDDEPVKKRGR.K 2 2.406 0.200 A clone MGC:2641 IMAGE:3507276, mRNA, complete cds. Homo sapiens, Similar to hypothetical GP:BC000936_1 protein, clone 1-2, clone MGC:5442 E.PGPSGLEIGSLLLPLL.L 2 2.778 0.232 G IMAGE:3449979, mRNA, complete cds. Homo sapiens, Similar to hypothetical IPI:IPI00031723.2 GP:BC001033_1 protein, clone MGC:1223 S.GGIVGYVKTGSVPSLAAWLL.F 2 2.440 0.251 O (99%) IMAGE:3139565, mRNA, complete cds. Homo sapiens, clone IMAGE:2822295, IPI:IPI00042295.1 GP:BC001077_1 A.RGRTLEPYPLVIAGEHNIPWL.L 2 2.608 0.083 O mRNA, partial cds. (94%) Homo sapiens, Similar to block of R.GSSEDDDEGDEEGEDGALDDEGHSGIKK IPI:IPI00028955.2 GP:BC001086_1 proliferation 1, clone IMAGE:2959877, 3 3.704 0.131 A TTEEQ.V (96%) mRNA, partial cds. Homo sapiens, clone IMAGE:3507281, GP:BC001096_1 Y.QGLSHLEALEILSNESESKVQSF.L 2 2.410 0.143 G mRNA, partial cds. Homo sapiens, Similar to KIAA0266 GP:BC001149_1 gene product, clone MGC:1291 L.IKAPEGPPRKDKNLPNVIINEKR.N 2 2.401 0.242 O IMAGE:3355662, mRNA, complete cds. Homo sapiens, hypothetical protein GP:BC001184_1 FLJ22059, clone MGC:2626 R.LLMHRYHHTGEYPYKCRECPR.S 2 2.210 0.166 O IMAGE:3502564, mRNA, complete cds. Homo sapiens, Similar to COP9 (constitutive photomorphogenic), subunit IPI:IPI00185211.1 GP:BC001187_1 L.LTNADYTTGQVFDLSEKLEQSEA.Q 2 2.441 0.166 A 5 (Arabidopsis), clone MGC:3149 (91%) IMAGE:3354130, mRNA, complete cds. Homo sapiens, clone IMAGE:3356192, GP:BC001200_1 V.PPQAPRCHVVIRGLCGEQPM.C 2 2.655 0.084 G, O mRNA, partial cds. Homo sapiens, pleckstrin 2 (mouse) GP:BC001226_1 homolog, clone MGC:4867 V.YYKLEGGRRVTPPK.G 2 2.201 0.207 A IMAGE:3457876, mRNA, complete cds. Homo sapiens, Similar to KIAA0092 GP:BC001233_1 gene product, clone MGC:4896 D.KATPCVPNARRIKKK.K 1 2.166 0.096 P IMAGE:3451715, mRNA, complete cds. Homo sapiens, tetratricopeptide repeat IPI:IPI00000606.2 GP:BC001276_1 domain 4, clone MGC:5097 R.GALCHLELKHFAEAVNWCDEGLQIDAK.E 3 3.592 0.173 P (96%) IMAGE:3462738, mRNA, complete cds. Homo sapiens, clone MGC:5149 IPI:IPI00107099.1 GP:BC001284_1 A.EMGFHHIGQDGLDLNLVIH.P 2 2.804 0.126 A IMAGE:3453653, mRNA, complete cds. (91%) Homo sapiens, clone MGC:3036 GP:BC001354_1 F.YQLCRDLDSSLRPSSSPGPR.A 2 2.221 0.100 O IMAGE:3163787, mRNA, complete cds. Homo sapiens, Similar to S-phase kinase-associated protein 2 (p45), clone IPI:IPI00163172.1 GP:BC001441_1 S.SNVATSFTWGWDSSKTSELLSGMGV.S 2 2.739 0.202 P MGC:1366 IMAGE:3138709, mRNA, (91%) complete cds. Homo sapiens, clone IMAGE:3138445, GP:BC001448_1 V.EVHEDVIDGAVLDPLKGVAHGV.A 2 2.506 0.131 A mRNA, partial cds. Homo sapiens, clone MGC:5054 GP:BC001555_1 F.FITTKPTPHLDGHHVVFGQVIS.G 2 2.600 0.208 P IMAGE:3461499, mRNA, complete cds. Homo sapiens, BRCA1 associated protein-1 (ubiquitin carboxy-terminal IPI:IPI00005808.1 GP:BC001596_1 R.IGLATAGEPYHDIR.F 2 2.260 0.150 P hydrolase), clone MGC:1530 (94%) IMAGE:3543914, mRNA, complete cds. Homo sapiens, D123 gene product, GP:BC001600_1 clone MGC:1935 IMAGE:3542611, V.TIKSVILPLPQ.N 2 2.428 0.159 A mRNA, complete cds. Homo sapiens, Similar to PDZ domain- containing guanine nucleotide exchange IPI:IPI00008865.1 GP:BC001956_1 P.MDMPGRELNEDRDSGIARSA.S 2 2.676 0.114 O factor I, clone MGC:667 (98%) IMAGE:3536789, mRNA, complete cds. Homo sapiens, acyl-Coenzyme A dehydrogenase family, member 8, clone F.ISGAGESDIYVVMCRTGGLGPKGISCIVVE IPI:IPI00003916.1 GP:BC001964_1 3 3.780 0.112 O MGC:4966 IMAGE:3462406, mRNA, KGTPGLS.F (99%) complete cds. Homo sapiens, Similar to alpha thalassemia/mental retardation syndrome GP:BC002521_1 X-linked (RAD54 (S. cerevisiae) N.SKEEGTSSSEKSKSSGSSRSK.R 2 2.617 0.125 G homolog), clone MGC:2094 IMAGE:3139907, mRNA, complete cds. Homo sapiens, clone MGC:2991 GP:BC002612_1 L.QPALDRP.A 1 2.033 0.148 A IMAGE:3160297, mRNA, complete cds. GP:BC002879_1 Homo sapiens, clone IMAGE:3940029, E.EEEEAEKELFIEDPSPAISI.L 2 2.566 0.107 A
Supplementary Table 2 57 mRNA, partial cds. Homo sapiens, clone IMAGE:3954961, IPI:IPI00106886.1 GP:BC002942_1 A.QRYKYWFSQPGEQGQWWRR.Q 2 2.202 0.140 P mRNA, partial cds. (92%) Homo sapiens, Similar to KIAA0193 GP:BC002980_1 gene product, clone IMAGE:3535762, G.GTRDRAGVLEEERMASS.S 2 3.095 0.134 G mRNA, partial cds. Homo sapiens, clone MGC:4107 IPI:IPI00024111.1 GP:BC003024_1 Y.TETRLQFDETAKHLQK.L 2 2.232 0.119 O IMAGE:2822570, mRNA, complete cds. (92%) Homo sapiens, coenzyme Q, 7 (rat, GP:BC003185_1 yeast) homolog, clone MGC:671 Q.EKDHLKKFNELMVTFR.V 2 2.375 0.104 A IMAGE:3503763, mRNA, complete cds. Homo sapiens, Similar to RIKEN cDNA GP:BC003516_1 4432405K22 gene, clone MGC:10751 V.QGNFEESQETMKRQLGRLLLLLRVL.D 2 2.618 0.093 A IMAGE:3050014, mRNA, complete cds. Homo sapiens, clone IMAGE:3609326, GP:BC003535_1 P.DFYLSNRCCILYVTEADLVAGNGYRKR.L 2 2.270 0.184 P mRNA, partial cds. Homo sapiens, Similar to RIKEN cDNA GP:BC003690_1 8430408O15 gene, clone MGC:5484 A.IATAAQASLLPYFPAIMEH.L 2 2.443 0.160 G IMAGE:3452343, mRNA, complete cds. Homo sapiens, clone MGC:5601 IPI:IPI00184016.1 GP:BC003698_1 A.WSLFQARRRGFAEGQGGSGTESGKLV.F 2 2.567 0.124 O IMAGE:3461017, mRNA, complete cds. (99%) Homo sapiens, Similar to RIKEN cDNA GP:BC004222_1 5430432M24 gene, clone MGC:4675 R.AEGAGRPPPATPPR.P 2 2.251 0.139 P IMAGE:3532660, mRNA, complete cds. Homo sapiens, Similar to RIKEN cDNA IPI:IPI00179032.1 GP:BC004331_1 2610207I16 gene, clone MGC:10940 K.VESTGA.V 1 1.801 0.095 G (98%) IMAGE:3630835, mRNA, complete cds. Homo sapiens, clone MGC:10981 GP:BC004397_1 A.KDTASLFIPLCGCSNSKS.G 2 2.507 0.163 A IMAGE:3636109, mRNA, complete cds. Homo sapiens, Similar to RIKEN cDNA GP:BC004535_1 1500015N03 gene, clone MGC:2993 V.ALALGALTVWHAVLISRGETSIERHINK.K 3 3.569 0.124 A IMAGE:3160750, mRNA, complete cds. Homo sapiens, Similar to cysteine and GP:BC004544_1 histidine-rich protein, clone C.CRNLAVEKAVSELPSECGF.C 2 2.640 0.228 O IMAGE:3945559, mRNA, partial cds. Homo sapiens, clone MGC:4607 GP:BC004903_1 Y.GDSRKFLLLGLR.P 2 2.464 0.158 A IMAGE:3501896, mRNA, complete cds. Homo sapiens, Similar to RIKEN cDNA IPI:IPI00031132.1 GP:BC004916_1 1810014G04 gene, clone MGC:4767 E.FKDMIEDAGFHKVTYESLTSGIVAI.H 2 2.599 0.128 O (94%) IMAGE:3538702, mRNA, complete cds. Homo sapiens, clone IMAGE:3605104, IPI:IPI00167638.1 GP:BC004923_1 P.RLGGEGGKGGDVWVVAQ.N 2 3.235 0.178 O, P mRNA, partial cds. (93%) Homo sapiens, Similar to RIKEN cDNA GP:BC004944_1 2310040G17 gene, clone R.SLLGVAATLAP.G 1 2.124 0.113 A IMAGE:3615328, mRNA, partial cds. Homo sapiens, Similar to feminization 1 a homolog (C. elegans), clone IPI:IPI00013226.1 GP:BC004988_1 L.DMQQSNLEPLSPMTASSFLSFA.E 2 2.698 0.080 G MGC:4216 IMAGE:2957950, mRNA, (92%) complete cds. Homo sapiens, clone MGC:4400 IPI:IPI00186571.1 GP:BC004992_1 V.LIKHEKTHIRETAINSLTVEK.P 2 2.628 0.204 P IMAGE:2905976, mRNA, complete cds. (99%) Homo sapiens, tumor suppressing subtransferable candidate 3, clone GP:BC005034_1 A.PAEDAVAAAAAA.P 1 2.086 0.098 G MGC:12714 IMAGE:3954346, mRNA, complete cds. Homo sapiens, Similar to RIKEN cDNA IPI:IPI00031571.1 GP:BC005131_1 2010003J03 gene, clone MGC:11102 C.KDHVRSLQK.E 1 2.021 0.098 A (93%) IMAGE:3831647, mRNA, complete cds. Homo sapiens, clone MGC:12173 GP:BC005184_1 E.FQSLFTEGLKSLTGIN.A 2 3.021 0.152 A IMAGE:3686608, mRNA, complete cds. Homo sapiens, zona pellucida binding IPI:IPI00013006.1 GP:BC005223_1 protein, clone MGC:12243 E.YKPTVEEIVKRL.Q 2 2.643 0.081 P (93%) IMAGE:3950015, mRNA, complete cds. Homo sapiens, Similar to immunoglobulin kappa constant, clone GP:BC005332_1 T.FGQGTKLEIKRTVAAPSVFIFPPSDEQLK.S 2 2.367 0.242 A MGC:12418 IMAGE:3934658, mRNA, complete cds. Homo sapiens, alpha 1,2-mannosidase, IPI:IPI00008207.1 GP:BC006079_1 clone MGC:12553 IMAGE:3959196, D.FISVTLSFGENYDNSK.S 2 2.319 0.125 G (94%) mRNA, complete cds. Homo sapiens, clone MGC:12950 IPI:IPI00217069.1 GP:BC006106_1 G.HYEEVELTETSVNVGPERIGPHSFELL.R 2 2.633 0.194 G IMAGE:2959036, mRNA, complete cds. (91%) Homo sapiens, clone MGC:13047 IPI:IPI00170975.1 GP:BC006131_1 G.GKAWDEQERDAYADRV.F 2 2.550 0.174 P IMAGE:3626506, mRNA, complete cds. (97%) Homo sapiens, HUS1 (S. pombe) IPI:IPI00004712.1 GP:BC007013_1 G.VSAENNEIYLELTSENLSRAL.K 2 2.697 0.085 G checkpoint homolog, clone MGC:12340 (92%)
Supplementary Table 2 58 IMAGE:3684398, mRNA, complete cds. Homo sapiens, Similar to KIAA0961 IPI:IPI00179218.1 GP:BC007064_1 protein, clone MGC:12515 S.QEEWECLNDDQRDLY.R 1 2.096 0.142 A (97%) IMAGE:3961390, mRNA, complete cds. Homo sapiens, Similar to RIKEN cDNA GP:BC007123_1 2610509G12 gene, clone MGC:5254 R.EDKVIPVTRSLRARNIVQSTEH.L 2 2.693 0.118 G IMAGE:3454033, mRNA, complete cds. Homo sapiens, chromosome 11 open GP:BC007198_1 reading frame2, clone MGC:12548 G.RPAGPDPLDPTDLNGAHF.D 2 2.477 0.165 P IMAGE:2961456, mRNA, complete cds. Homo sapiens, clone IMAGE:2905978, IPI:IPI00172590.1 GP:BC007209_1 V.ATVLQAASRDLDWEVR.A 2 2.478 0.160 G mRNA, partial cds. (95%) Homo sapiens, clone MGC:15514 IPI:IPI00012365.2 GP:BC007256_1 P.LAAGTGLQGLQTDIQTDNDLTK.E 2 2.234 0.101 A IMAGE:3028040, mRNA, complete cds. (97%) Homo sapiens, clone MGC:15718 GP:BC007312_1 Y.KVRGVSVSLSLGEAPGGGLFLPPPSP.L 2 2.442 0.175 A IMAGE:3353436, mRNA, complete cds. Homo sapiens, clone MGC:16282 GP:BC007391_1 A.EGAAAQPQAVLRQPELRV.I 2 2.488 0.125 A IMAGE:3832727, mRNA, complete cds. Homo sapiens, chromosome 4 open IPI:IPI00007344.1 GP:BC007732_1 reading frame 1, clone MGC:12570 T.AEGIGAELKA.P 1 2.112 0.090 G (94%) IMAGE:4109702, mRNA, complete cds. Homo sapiens, clone IMAGE:4139775, IPI:IPI00063388.1 GP:BC007772_1 T.IEPVQQAGCSATR.L 1 2.073 0.082 A mRNA, partial cds. (93%) Homo sapiens, clone MGC:10992 GP:BC008285_1 L.ELVESLLKSMPE.E 2 2.487 0.110 G IMAGE:3637387, mRNA, complete cds. Homo sapiens, clone MGC:15062 IPI:IPI00186853.1 GP:BC008300_1 I.LNALTIDAFLISNHRRLG.T 2 2.554 0.163 P IMAGE:2959567, mRNA, complete cds. (92%) Homo sapiens, actin-related protein 3- IPI:IPI00023929.1 GP:BC008682_1 beta, clone MGC:9359 IMAGE:3854008, R.AEPEDHYFLMTEPPLNTPE.N 3 3.716 0.138 O (98%) mRNA, complete cds. Homo sapiens, putative secreted protein, GP:BC008742_1 clone MGC:660 IMAGE:3346733, L.LAFAGYSGLLAGVEVSAG.S 2 2.598 0.103 P mRNA, complete cds. Homo sapiens, clone IMAGE:4129520, IPI:IPI00218520.1 GP:BC008841_1 K.PSLVVELAR.D 1 1.854 0.092 A mRNA, partial cds. (96%) Homo sapiens, clone IMAGE:4179671, GP:BC009033_1 L.GGQGNWGPEDAPGLLAR.A 2 2.448 0.120 P mRNA, partial cds. Homo sapiens, isocitrate dehydrogenase 2 (NADP+), mitochondrial, clone IPI:IPI00071050.1 GP:BC009244_1 L.SNVKLNEHFLNTTDFLDTIKS.N 3 3.984 0.260 O MGC:3700 IMAGE:2959540, mRNA, (99%) complete cds. Homo sapiens, clone IMAGE:4139111, IPI:IPI00150554.1 GP:BC009352_1 C.RKRDGRCATGILIHLAK.F 2 2.345 0.231 A mRNA, partial cds. (91%) Homo sapiens, Similar to RIKEN cDNA GP:BC009361_1 2310010N19 gene, clone MGC:15330 K.RPPSDIHDSDGSSSSSHQSLK.S 2 2.487 0.111 A IMAGE:4301597, mRNA, complete cds. Homo sapiens, SET domain, bifurcated IPI:IPI00018321.1 GP:BC009362_1 1, clone MGC:15194 IMAGE:4301680, A.HVDQLFDDASR.A 2 2.255 0.130 A (94%) mRNA, complete cds. Homo sapiens, clone MGC:15887 GP:BC009447_1 A.ALPAKPPNLDAALALLRKEMV.G 2 2.455 0.182 A IMAGE:3530481, mRNA, complete cds. Homo sapiens, Similar to CG8974 gene L.CGHLFCWPCLHQWLETRPNRQVCPVCKA GP:BC009504_1 product, clone MGC:2460 3 3.858 0.080 O G.I IMAGE:2964524, mRNA, complete cds. Homo sapiens, bile acid Coenzyme A: amino acid N-acyltransferase (glycine N- IPI:IPI00017819.1 GP:BC009567_1 Q.LKRHGKNNWTLLSYPGAG.H 2 3.079 0.104 G choloyltransferase), clone MGC:12333 (93%) IMAGE:4071788, mRNA, complete cds. Homo sapiens, clone IMAGE:3897193, GP:BC009725_1 F.LEINRQLLFREYLDGSSMI.P 2 2.611 0.104 A mRNA, partial cds. Homo sapiens, hypothetical protein IPI:IPI00181747.1 GP:BC009746_1 FLJ20436, clone MGC:1043 L.SVPDDLEAGPMDLYLS.A 1 2.398 0.113 P (98%) IMAGE:3503970, mRNA, complete cds. Homo sapiens, clone MGC:16393 GP:BC009866_1 A.RNARPEPGARHPALPAM.V 2 2.434 0.124 G IMAGE:3939021, mRNA, complete cds. Homo sapiens, clone IMAGE:4100024, IPI:IPI00004948.1 GP:BC009943_1 H.SPLDSADVR.V 1 1.903 0.216 A mRNA, partial cds. (96%) Homo sapiens, hypothetical protein IPI:IPI00014865.1 GP:BC010005_1 DKFZp434E1723, clone MGC:15106 I.ESRSASPDSRKVVK.W 2 2.247 0.161 O, P (97%) IMAGE:4131938, mRNA, complete cds. Homo sapiens, cell death regulator aven, S.ERPGAAAAVARGGGGGGGGDGGGRRG IPI:IPI00006904.1 GP:BC010488_1 clone MGC:16897 IMAGE:2900586, 3 3.524 0.095 G RGRGR.G (91%) mRNA, complete cds. Homo sapiens, Similar to RIKEN cDNA GP:BC010541_1 2300002L21 gene, clone MGC:17528 A.DKLIQNLDANHDGRISFDEYWT.L 2 2.675 0.120 P IMAGE:3458906, mRNA, complete cds.
Supplementary Table 2 59 Homo sapiens, clone MGC:17167 GP:BC010611_1 L.KGWGGDRPK.G 1 1.867 0.107 G IMAGE:4183414, mRNA, complete cds. Homo sapiens, hypothetical protein GP:BC010661_1 FLJ10847, clone MGC:8805 V.YMVPAGFSVAASVRVGNALGAGDME.Q 2 2.454 0.166 G IMAGE:3874616, mRNA, complete cds. Homo sapiens, clone MGC:9168 GP:BC010857_1 S.ARASVSRFSDQEFEVTFLSSVEK.L 2 2.257 0.170 A IMAGE:3876839, mRNA, complete cds. Homo sapiens, Similar to eukaryotic translation initiation factor 4E binding GP:BC010881_1 Y.ATTPGGTRIIYDRKFLLECKNSPIAR.T 2 2.312 0.102 P protein 3, clone MGC:1999 IMAGE:3542582, mRNA, complete cds. Homo sapiens, Similar to hypothetical GP:BC011625_1 protein FLJ14299, clone MGC:10743 P.SAPTSSSVLGSGLVAPV.S 2 2.683 0.145 G IMAGE:4053098, mRNA, complete cds. Homo sapiens, Similar to RIKEN cDNA GP:BC011706_1 5430428G01 gene, clone MGC:19780 I.CVSALLLGILGIKKVIIVYVESIC.R 2 2.431 0.153 G IMAGE:3689162, mRNA, complete cds. Homo sapiens, clone IMAGE:3927737, GP:BC011715_1 G.VPAADDVKCGVGPGRSCSMQQR.S 2 2.324 0.125 G mRNA, partial cds. Homo sapiens, clone MGC:21259 IPI:IPI00012830.1 GP:BC012012_1 L.KPKDTIAMQNIPGGKTSNGINTNCV.R 2 2.413 0.159 G IMAGE:4509206, mRNA, complete cds. (99%) Homo sapiens, clone IMAGE:3502817, T.LAPNASSLGPGTDLALAPASSAGPGPGLS GP:BC012048_1 2 2.458 0.115 O mRNA, partial cds. L.G Homo sapiens, Similar to KIAA1696 GP:BC012187_1 protein, clone MGC:20476 A.PSTAVSVVSDSIKVQP.L 1 2.048 0.112 O IMAGE:4634631, mRNA, complete cds. Homo sapiens, Similar to solute carrier family 22 (organic cation transporter), IPI:IPI00008804.1 GP:BC012325_1 V.DLGQLEQESCPDGWEFS.Q 1 2.027 0.258 P member 5, clone MGC:20139 (97%) IMAGE:4548603, mRNA, complete cds. Homo sapiens, Similar to ring finger GP:BC012583_1 protein 2, clone MGC:13490 E.GLKIQAMNR.L 1 1.889 0.139 G IMAGE:4285715, mRNA, complete cds. Homo sapiens, clone MGC:15361 IPI:IPI00181403.1 GP:BC012745_1 A.PHMADIGSVTSSASGPAQSVAKM.F 2 2.454 0.229 O IMAGE:4025242, mRNA, complete cds. (94%) Homo sapiens, Similar to RNA binding motif protein, X chromosome, clone GP:BC012942_1 L.LIKDRETNKSRGFAFVTFESPADA.K 2 2.650 0.143 O MGC:9398 IMAGE:3875565, mRNA, complete cds. Homo sapiens, clone MGC:9925 IPI:IPI00022001.1 GP:BC012944_1 A.YPYVESETVEQ.D 1 2.164 0.108 A IMAGE:3872311, mRNA, complete cds. (92%) Homo sapiens, clone MGC:16098 IPI:IPI00142906.2 GP:BC012981_1 R.GGHLGVVKLLLEAGAFVDHHHP.S 2 2.634 0.116 G IMAGE:3620129, mRNA, complete cds. (97%) Homo sapiens, Similar to hypothetical GP:BC013069_1 protein FLJ13059, clone MGC:18060 H.TRPIFLFLVETGFSHVGQAGL.E 2 2.420 0.184 A IMAGE:4149342, mRNA, complete cds. Homo sapiens, clone MGC:5167 IPI:IPI00008134.2 GP:BC013124_1 L.SKVKVFTKSAHG.G 2 2.608 0.102 A IMAGE:3048375, mRNA, complete cds. (97%) Homo sapiens, Similar to ralA binding GP:BC013126_1 protein 1, clone MGC:5006 E.FLLNCLHRDLQGGIKDLSK.E 2 2.216 0.133 A IMAGE:3049077, mRNA, complete cds. Homo sapiens, clone MGC:16467 IPI:IPI00178971.1 GP:BC013282_1 S.QDGNACPKCPEQAAEASV.R 1 2.317 0.234 O IMAGE:3952931, mRNA, complete cds. (99%) Homo sapiens, hypothetical protein IPI:IPI00016691.1 GP:BC013696_1 FLJ20635, clone MGC:8848 L.HIHGLYRDPCGVVLDPSGYK.D 2 2.272 0.118 O (99%) IMAGE:3860694, mRNA, complete cds. Homo sapiens, clone MGC:2815 IPI:IPI00012568.2 GP:BC013951_1 A.KPKEKIEYKCSE.R 2 2.654 0.113 O IMAGE:2963683, mRNA, complete cds. (99%) Homo sapiens, clone MGC:20208 GP:BC014000_1 I.HTGEKPYHCPDCGRCFRRSRSLAN.H 2 2.619 0.220 G IMAGE:3936339, mRNA, complete cds. Homo sapiens, clone IMAGE:3959980, P.AGQGNRRGGGLLVRPSPPNSGPLAAPGD GP:BC014011_1 2 2.368 0.159 A mRNA, partial cds. HRVR.P Homo sapiens, transcriptional co- activator with PDZ-binding motif (TAZ), IPI:IPI00178584.1 GP:BC014052_1 M.NLHPAVSSTPVPQR.S 1 1.975 0.115 G clone MGC:19891 IMAGE:3635491, (91%) mRNA, complete cds. Homo sapiens, clone MGC:20632 Q.QTALELVGRGVEVHIVADATSSRSMMDR IPI:IPI00101018.1 GP:BC014105_1 3 3.788 0.121 O IMAGE:4129769, mRNA, complete cds. MFAL.E (94%) Homo sapiens, clone MGC:20806 GP:BC014109_1 L.RAAGAEALGKLLQQNKSIQSLTLE.W 2 2.678 0.114 O IMAGE:4330269, mRNA, complete cds. Homo sapiens, clone MGC:20630 GP:BC014209_1 V.GEGEQVTITLPNI.E 2 2.726 0.091 O IMAGE:4765823, mRNA, complete cds. Homo sapiens, clone IMAGE:4554490, GP:BC014236_1 A.ANILNVVVLTASMSAYNSGLYSN.G 2 2.415 0.142 A mRNA, partial cds. Homo sapiens, Similar to IPI:IPI00060412.1 GP:BC014339_1 D.GWEYAFEGTAGRFL.T 2 2.419 0.118 P transmembrane 4 superfamily member 1, (93%)
Supplementary Table 2 60 clone MGC:23935 IMAGE:3828466, mRNA, complete cds. Homo sapiens, Similar to acetyl- Coenzyme A transporter, clone K.SGPLPPGGWDDSHLDSAGREGDREALLG IPI:IPI00006205.1 GP:BC014416_1 3 3.624 0.326 A MGC:20012 IMAGE:4559958, mRNA, DTGTGDFLKAP.Q (93%) complete cds. Homo sapiens, Similar to RIKEN cDNA S.QAETELQRAAMDASRTSRHLEETINNFER. IPI:IPI00167542.1 GP:BC014598_1 6720467C03 gene, clone MGC:26639 2 2.400 0.150 P Q (99%) IMAGE:4826612, mRNA, complete cds. Homo sapiens, clone IMAGE:3503007, GP:BC014632_1 R.DATHQEAVSALL.R 1 1.993 0.087 A mRNA, partial cds. Homo sapiens, Similar to RIKEN cDNA GP:BC014642_1 1810073N04 gene, clone MGC:15523 L.AVGGGEKAKGGPPPGNAAGDTGQPAE.D 2 2.537 0.151 A IMAGE:3028844, mRNA, complete cds. Homo sapiens, Similar to hypothetical IPI:IPI00165115.1 GP:BC014891_1 protein FLJ20302, clone MGC:10184 Q.MIRIEADATQSSHLEIM.C 2 3.224 0.195 G (92%) IMAGE:3908507, mRNA, complete cds. Homo sapiens, hypothetical protein GP:BC014945_1 FLJ13063, clone MGC:22948 L.EAAGRFLL.P 2 2.440 0.114 O IMAGE:4860377, mRNA, complete cds. Homo sapiens, clone MGC:9645 IPI:IPI00184016.1 GP:BC015056_1 I.PSGTILKALMEGGENGPWMR.F 2 2.316 0.110 P IMAGE:3922910, mRNA, complete cds. (99%) Homo sapiens, Similar to RIKEN cDNA IPI:IPI00009366.1 GP:BC015175_1 4930429A08 gene, clone MGC:10147 N.RRSVLEKNLIKVTVA.P 2 2.813 0.088 O (99%) IMAGE:3904501, mRNA, complete cds. Homo sapiens, clone MGC:21685 IPI:IPI00149650.1 GP:BC015385_1 I.ESIAVSSEGALFCSVGDDKAMKVFDV.V 2 2.555 0.260 A IMAGE:4390706, mRNA, complete cds. (99%) Homo sapiens, Similar to hypothetical IPI:IPI00018871.1 GP:BC015408_1 protein FLJ10702, clone MGC:21954 E.ASKNELHNLLDK.P 2 2.433 0.142 A (91%) IMAGE:4391821, mRNA, complete cds. Homo sapiens, clone MGC:21987 GP:BC015419_1 Q.RAHSVDVEKNR.K 2 2.365 0.105 P IMAGE:4396825, mRNA, complete cds. Homo sapiens, clone IMAGE:4430701, IPI:IPI00020128.1 GP:BC015454_1 F.HVSLLSIAQLFD.F 2 2.709 0.087 P mRNA, partial cds. (97%) Homo sapiens, clone IMAGE:3954884, GP:BC015561_1 L.DSLDSATPVNSICSVQ.G 2 2.688 0.092 G mRNA, partial cds. Homo sapiens, clone MGC:23445 T.PFLHQRNGNAARSLTSLTSDDNLWACLHT IPI:IPI00154569.2 GP:BC015687_1 3 3.760 0.219 O IMAGE:4684974, mRNA, complete cds. SFAW.L (95%) Homo sapiens, chromatin accessibility GP:BC015891_1 complex 1, clone MGC:16846 A.DILPKKILASKYLKMLKEEKR.E 2 2.366 0.137 G IMAGE:3908717, mRNA, complete cds. Homo sapiens, clone MGC:20058 IPI:IPI00184357.1 GP:BC015913_1 A.SLATAAGSEDAEKK.V 2 2.498 0.124 G, O IMAGE:4563632, mRNA, complete cds. (94%) Homo sapiens, clone MGC:20464 GP:BC015921_1 R.ASRTDLVFGSGSA.A 1 1.953 0.109 O IMAGE:4551151, mRNA, complete cds. Homo sapiens, molybdopterin synthase GP:BC015939_1 sulfurylase, clone MGC:9252 L.LAEQEPQPERLVPVSPLPPK.A 2 2.307 0.153 O IMAGE:3908290, mRNA, complete cds. Homo sapiens, Similar to thymus GP:BC016161_1 expressed gene 3, clone MGC:15476 A.SAVPSGPP.K 1 2.070 0.140 A IMAGE:2967514, mRNA, complete cds. Homo sapiens, Similar to immunoglobulin kappa constant, clone GP:BC016380_1 A.SQIVSSAYLAWYQQKPGQAPR.L 2 2.467 0.101 G MGC:27376 IMAGE:4688477, mRNA, complete cds. Homo sapiens, clone MGC:16818 GP:BC016395_1 -.MADPGPDPESESESVFPREVGLF.A 2 2.426 0.126 P IMAGE:3882414, mRNA, complete cds. Homo sapiens, hypothetical protein Y.FASPKYPAQSGKKKKLLLPSSSWQLDIKN GP:BC016513_1 FLJ20831, clone MGC:8840 2 2.448 0.177 P KNI.R IMAGE:3861212, mRNA, complete cds. Homo sapiens, Similar to growth GP:BC016658_1 accentuating protein 43, clone L.LQYLCVQSPAVTSSSDPQEHP.T 2 2.478 0.258 O IMAGE:3923850, mRNA, partial cds. Homo sapiens, clone IMAGE:4389250, GP:BC016683_1 E.RLSGLFLNEEVLSLKV.T 2 2.867 0.153 O mRNA, partial cds. Homo sapiens, Similar to hypothetical GP:BC016904_1 protein 24432, clone MGC:21034 L.QDAEAAVAGPSHAPDTSDVGAT.L 2 2.839 0.123 G IMAGE:4400396, mRNA, complete cds. Homo sapiens, chromosome 12 open IPI:IPI00006906.1 GP:BC016908_1 reading frame 4, clone MGC:21060 R.ESVEAIGRIYEEQRKLEESFTIHLGAQ.L 3 3.560 0.112 A (95%) IMAGE:4402263, mRNA, complete cds. Homo sapiens, clone MGC:9535 IPI:IPI00156743.1 GP:BC017169_1 I.GLASLFTENVLAHPCIVLRR.Q 2 2.662 0.116 O IMAGE:3923005, mRNA, complete cds. (96%) Homo sapiens, far upstream element GP:BC017247_1 (FUSE) binding protein 1, clone P.SSGSAGGGGGGGGGGGVNDA.F 2 2.489 0.116 O, P MGC:29580 IMAGE:4891583, mRNA,
Supplementary Table 2 61 complete cds. Homo sapiens, hypothetical protein GP:BC017306_1 DKFZp434J037, clone MGC:29812 L.SSESFDQLDLPER.L 2 2.491 0.212 P IMAGE:5088037, mRNA, complete cds. Homo sapiens, Similar to kinesin family GP:BC017311_1 member C2, clone MGC:29716 A.AAAAEPGDPAQRAR.K 2 2.335 0.103 A IMAGE:5090622, mRNA, complete cds. Homo sapiens, clone MGC:29726 IPI:IPI00000856.1 GP:BC017327_1 T.SENHLNNSDKEVDEVDAA.L 1 2.001 0.180 P IMAGE:4547604, mRNA, complete cds. (93%) Homo sapiens, clone MGC:29484 GP:BC017347_1 V.CFLLLLTLLGFL.E 2 2.623 0.117 P IMAGE:5014808, mRNA, complete cds. Homo sapiens, clone MGC:29525 IPI:IPI00073596.1 GP:BC017352_1 A.KKPPVTFAEKGE.L 2 2.479 0.112 A IMAGE:5013158, mRNA, complete cds. (92%) Homo sapiens, clone MGC:23998 IPI:IPI00103263.1 GP:BC017393_1 M.IRLLELEQDASSAKLLNEK.D 2 2.343 0.123 O IMAGE:4045063, mRNA, complete cds. (94%) Homo sapiens, clone MGC:15775 IPI:IPI00103247.1 GP:BC017480_1 I.KYKVFDAKPSAK.T 1 1.914 0.093 A IMAGE:3502860, mRNA, complete cds. (92%) Homo sapiens, clone IMAGE:4864317, L.KSCLSKSKRDSGEGPGKKPPSVFGSTAER GP:BC017511_1 2 2.518 0.110 A mRNA, partial cds. MRQE.G Homo sapiens, likely ortholog of mouse coiled coil forming protein 1, clone GP:BC017556_1 G.GECMAADRRVCTYSAGTDTNPIF.L 2 2.401 0.161 O MGC:9519 IMAGE:3908134, mRNA, complete cds. Homo sapiens, triggering receptor expressed on myeloid cells 1, clone IPI:IPI00032847.1 GP:BC017773_1 A.DVSTPDSEINLTNVTDIIR.V 2 2.633 0.158 P MGC:22242 IMAGE:4692680, mRNA, (94%) complete cds. Homo sapiens, clone MGC:22262 GP:BC017778_1 Y.NPAELEEKDAIGVRR.A 2 2.370 0.115 P IMAGE:4291149, mRNA, complete cds. Homo sapiens, clone MGC:9349 IPI:IPI00152556.1 GP:BC018137_1 C.SGSLDGVEYSQR.K 2 2.287 0.174 G IMAGE:3846611, mRNA, complete cds. (97%) Homo sapiens, clone IMAGE:3464710, IPI:IPI00217811.1 GP:BC018205_1 L.QRLQALLQDLSEV.S 1 2.260 0.082 G mRNA, partial cds. (97%) Homo sapiens, clone MGC:3256 IPI:IPI00180305.1 GP:BC018694_1 L.TVDKDQLVMLLDQINS.T 2 2.416 0.128 O IMAGE:3506191, mRNA, complete cds. (97%) Homo sapiens, clone MGC:20634 GP:BC019043_1 F.KLTQGGPGNSSHVAISAPV.S 2 2.465 0.165 G IMAGE:4641145, mRNA, complete cds. Homo sapiens gene for Ig heavy chain GP:D11018_1 C.QVPLVESGGGVVQPGR.S 2 2.462 0.204 G variable region, partial cds. Human mRNA for type VII collagen, IPI:IPI00025418.1 GP:D13694_1 T.ALVGDHEGTPVSIVVTTPPEAPPA.L 2 2.701 0.124 G partial sequence. (94%) Homo sapiens mRNA for H-2K binding GP:D14041_1 A.IISTHKAKYTF.Y 2 2.403 0.128 G factor-2, complete cds. Human mRNA for beta-1,4- IPI:IPI00215767.1 GP:D29805_1 Q.RQQLDYGIYVINQAGDTIFNRA.K 2 2.502 0.204 O galactosyltransferase, complete cds. (98%) Human mRNA for KIAA0077 gene, IPI:IPI00005260.1 GP:D38521_1 partial cds; The ha0919 gene product is L.TYLQTMVF.Y 1 2.039 0.094 A (95%) novel.. Human mRNA for KIAA0078 gene, complete cds; The ha1237 gene product IPI:IPI00180635.1 GP:D38551_1 V.DSVKELDSKTIRAQLSD.Y 2 2.636 0.082 A is related to S.pombe rad21 gene (99%) product.. Human mRNA for NRAMP1, complete GP:D50402_1 S.PTSPTSPGPRQAPPR.E 2 2.350 0.144 G cds. Human mRNA for KIAA0131 gene, L.YFRSLEPPLFPPDLFGELLASSELEATAER. GP:D50921_1 partial cds; The KIAA0131 gene product 2 2.235 0.175 A V is novel.. Human mRNA for KIAA0149 gene, IPI:IPI00169258.1 GP:D63483_1 complete cds; The KIAA0149 gene F.RGARCELPCPAGSHGVQCAHSCGRC.K 2 2.780 0.320 O, P (96%) product is related to Notch3.. Human mRNA for KIAA0150 gene, GP:D63484_1 partial cds; The KIAA0150 gene product G.PSWRKKYSLVNR.P 2 2.681 0.146 A is novel.. Human mRNA for KIAA0157 gene, IPI:IPI00014176.1 GP:D63877_1 partial cds; KIAA0157 gene product is Y.RFRRNTQQQMSYREQ.V 2 2.737 0.170 A (97%) novel.. Human mRNA for KIAA0187 gene, IPI:IPI00165661.2 GP:D80009_1 A.EFEDQDDEARV.Q 2 2.413 0.147 P complete cds. (98%) Homo sapiens DCRR1 mRNA, partial IPI:IPI00023977.1 GP:D83327_1 A.ENVAGHQIASETQILEG.S 2 2.613 0.092 A cds. (92%) Homo sapiens mRNA for RP105, IPI:IPI00023722.1 GP:D83597_1 L.KVLDFQNNAIHYISREDMRS.L 2 2.447 0.122 A complete cds. (95%) Human immunoglobulin (mAb58) light GP:D84142_1 L.LIYGAASLQSGVPSR.F 2 2.201 0.169 G chain V region mRNA, partial sequence. Human mRNA for KIAA0223 gene, V.ARFAEGLEKLKECVLRDDLLEARRPRAHE GP:D86976_1 3 3.822 0.111 G partial cds; similar to C.elegans protein CLGEAL.R
Supplementary Table 2 62 (Z37093). Human mRNA for KIAA0234 gene, GP:D87072_1 complete cds; similar to Human XE169 G.GNVSSTLLKQHLSL.E 1 2.107 0.141 G protein(P41229). Human mRNA for KIAA0278 gene, IPI:IPI00000357.1 GP:D87468_1 partial cds; Similar to Rat growth factor G.PRPPDPSAGPPSVR.P 2 2.371 0.227 P (93%) Arc (U19866). Homo sapiens mRNA for TP55, complete GP:D88575_1 Y.GNSSNSQSGL.Q 1 2.122 0.103 G cds. Schizosaccharomyces pombe mRNA, partial cds, clone: SY 0551; similar to GP:D89139_1 Human electron transfer flavoprotein I.VTVRASAFDAAPSSGEGAATVVGGIDPK.P 2 2.564 0.131 P alpha subunit precursor, SWISS-PROT Accession Number P13804. Homo sapiens mRNA for zinc finger 5 IPI:IPI00020117.1 GP:D89859_1 L.FKKLEVDSSSVIEIDFLRS.D 3 3.901 0.092 P protein, complete cds. (93%) Human Ig gamma3 heavy chain disease GP:J00231_1 OMM protein mRNA; OMM protein (Ig P.CPXCPAPELLGGPSVFLFPPKPK.D 2 2.466 0.171 G, O gamma3) heavy chain. Human beta-spectrin (SPTB) mRNA, IPI:IPI00216513.1 GP:J05500_1 complete cds; spectrin Rouen (beta-220- R.DVHLLGVQVQQFQD.V 1 2.116 0.088 A (99%) 218) mutant coding sequence. Human Ig active heavy chain epsilon-1 IPI:IPI00003994.1 GP:L00022_1 gene, constant region; Ig heavy chain Q.GTTVTVSSASTQ.S 2 3.185 0.387 G (97%) epsilon-1 (V-D-J region). Human Ig rearranged mu-chain mRNA GP:L03385_1 variable region (V3), diversity region, N.WGQGTLVTVSSGSRS.A 2 4.012 0.193 G joining region (J4), partial cds; putative. Human Ig rearranged gamma-chain GP:L06920_1 mRNA V-region, 5' end of cds (from Q.LVESGGDLVKPGQ.S 2 3.134 0.192 G clone S5P14). Human Ig rearranged H-chain mRNA V3- D-J1-region, partial cds from clone 23; GP:L07309_1 Q.APGKGLEWLSYISSSGRYIY.Y 2 2.413 0.237 A sequence begins in first framework; putative. Human cytokine receptor (EBI3) mRNA, IPI:IPI00034088.1 GP:L08187_1 P.GSWPFPEIF.S 2 2.416 0.114 G complete cds. (99%) Homo sapiens surfactant protein A IPI:IPI00021398.1 GP:L10123_1 Y.TLILTCIIVRVLCPPVGCKSYK.D 2 2.441 0.133 A mRNA, complete cds. (94%) Human surfactant protein B mRNA, GP:L11573_2 Y.SGAASTGQVKVVHDVSMDLTGR.D 2 2.488 0.171 P complete cds; ORF. Human IgH (thyroid peroxidase-specific GP:L12105_1 Fab fragment) mRNA, partial cds; clone K.EPGASVE.V 1 1.888 0.085 G TR1.21. Human Ig rearranged H-chain gene V- GP:L19426_1 R.WYNDYVVSAK.S 2 2.254 0.197 G region, partial cds; anti-concanavalin A. Human IgH chain VDJC region mRNA, GP:L23570_1 T.LVTVSPGSASAPTLFPLVXIR.- 2 2.339 0.213 P partial cds; Xxx. Human transformation-related protein IPI:IPI00018874.1 GP:L24521_1 G.LELLTSSVPPTSAFPKCWDYRR.D 2 2.300 0.217 O mRNA, 3' end. (95%) Pan troglodytes mRNA sequence, 3'end IPI:IPI00175265.1 GP:L24922_1 of ORF; Possible homologue to human T.PVCDRIICGLPPTIANGDFTSISR.E 2 2.318 0.106 P (95%) CR1-like genomic element. Human immunoglobulin heavy-chain-2 S.GAEVKKPGASVRISCKASGYTFTSYCMH GP:L25542_1 light-chain-2 VH segment V13C (IGHV) 2 2.456 0.146 O W.V exon 2, 5' end. Homo sapiens immunoglobulin variable GP:L26534_1 S.YVLTQPPSLSLAPGQTAT.I 2 3.061 0.139 O region mRNA, partial cds. Human androgen receptor mRNA, G.GGGGGGGGGGGGGGGGGGGGGGGGE GP:L29496_1 2 2.570 0.116 O complete cds; androgen receptor. AEAVAPYGY.T Human immunoglobulin kappa light chain (IGKV) mRNA variable region and joining region; This CDS feature is included to IPI:IPI00030205.1 GP:L33032_2 Y.GSLWTFGQGTK.- 2 2.228 0.229 P show the translation of the corresponding (95%) V_region. Presently translation qualifiers on V_region features are illegal.. Homo sapiens (clone S12) gene from GP:L33996_1 CpG-enriched DNA, partial cds; ORF; S.TDKAGVVAEYPAR.S 2 2.617 0.092 A putative. Homo sapiens (clone S31i125) mRNA, 3' IPI:IPI00028055.1 GP:L40397_1 G.PPARXGPFPLALLLLFLLGPRLVLAI.S 2 2.804 0.130 A, P end of cds; ORF; putative. (93%) Homo sapiens (clone NBML1) Ig lambda light chain V-region (VL1) gene, partial GP:L40592_1 cds; This CDS feature is included to I.ENENVSWYQQLPGTAPK.L 2 2.444 0.206 G show the translation of the corresponding V_region. Presently translation qualifiers
Supplementary Table 2 63 on V_region features are illegal.. Homo sapiens (clone JRSYN14) GP:L40718_1 immunoglobulin kappa light chain mRNA, R.FSGSGSGTDFSLTISR.L 2 2.333 0.299 G partial cds; putative. Homo sapiens (clone NS-5 65P-71-1 and NS-5 65P-91-3) T cell receptor alpha GP:L42792_1 chain (TCRA) mRNA, partial cds; Partial H.QDLNYGGSQGNLIF.G 2 2.410 0.185 O TCRVA (1..9), TCRNA (10..51), TCRJA (52..93) , partial TCRCA (94..105). Homo sapiens (clone H 4.4) latent IPI:IPI00141644.1 GP:L48925_1 transforming growth factor-beta binding S.RTFNVALNARYSRSSAAA.G 1 2.124 0.082 G (98%) protein (LTBP-1L) gene, partial cds. Homo sapiens transcription factor ZFM1 Q.QYGFQYPLAMAAKIPPRGGDGPSHESED IPI:IPI00017271.2 GP:L49345_1 isoform B3 mRNA, complete cds; isoform 2 2.466 0.128 A FPR.P (93%) B3. Homo sapiens MHC class I (HLA-B) IPI:IPI00180213.1 GP:L76639_1 A.GSHTWQTMYGSHVGPDGRLLRG.H 2 2.485 0.105 G mRNA, HLA-B*39061 allele, partial cds. (92%) Homo sapiens excision repair protein R.TLLQYLSQYDCVTFLNLLESLRATEKAFG. IPI:IPI00219179.1 GP:L77890_1 ERCC4 mRNA, complete cds, clone 3 3.520 0.082 O, P Q (91%) cer4-40; putative. Homo sapiens immunoglobulin lambda GP:M18337_1 light chain VJ3 region (IGL@) gene, L.DQDRPSGIPER.F 2 2.476 0.176 G partial cds; putative. Human Ig heavy chain J5-J6-region GP:M20580_1 D.DCVVGLCPLQGTRSLGGSPR.G 2 2.390 0.115 O DNA; Ig heavy chain J5-region. Human alpha satellite and satellite 3 GP:M21305_1 N.SSGMEWNGMEW.N 2 2.506 0.167 G junction DNA sequence; ORF 1; putative. Human T-cell receptor germline delta- GP:M22150_1 chain C-region DNA, exon 3; delta-chain S.KSCHKPKAIVHTEKVNMMSL.T 2 2.514 0.139 A (C-delta region). Human angiotensinogen (AGT) gene, IPI:IPI00032220.1 GP:M24689_1 L.SGMGTFQHWSDIQDNFSVTEVPF.T 2 2.545 0.110 O exon 5. (97%) Human 17 beta-hydroxysteroid GP:M29037_1 dehydrogenase (17BHSDI) gene, exons R.NSSSLAAARERVTEGRVD.V 1 1.890 0.088 O 1-5, complete cds. Human Ig myeloma protein NEWM framework region and mouse monoclonal GP:M30885_1 antibody B1-8 V-region HuV-NP gene, 5' P.GLVRPSQTLSLTCTVSGSTFSSYW.M 2 2.406 0.146 G end; Ig HuV-NP fusion protein precursor V-region. Human TFEB protein mRNA, partial cds; GP:M33782_1 V.TAGARAPARGSVTAEAAARAGRGSGR.G 2 2.305 0.283 P TFEB protein. Human Gata3 enhancer-binding protein G.TGHYLCRRCGLYHKMNGQNRPLIKPKRR. GP:M69106_1 2 2.416 0.159 A mRNA, complete cds. L Human Ig active gamma-chain V(H), GP:M71218_1 K.PSQTLSLTCAVSGDSVSSNSAAWNWI.R 2 2.705 0.093 G D(J), J(H) mRNA partial cds, clone FG9. Homo sapiens clone FF11 immunoglobulin heavy chain VDJC GP:M71222_1 V.KGRIIVNPDTSTNQF.S 1 2.012 0.118 G region mRNA, partial cds; immunoglobulin gamma chain. Human TB3-1 mRNA, complete cds; high GP:M75715_1 homology to yeast omnipotent supressor Y.NKVPPNGLEVYCGTIV.T 2 2.486 0.142 P 45; putative. Human nuclease sensitive element IPI:IPI00219147.1 GP:M85234_1 A.AQGAVAR.A 1 1.837 0.138 A binding protein-1 mRNA, complete cds. (94%) Human (hybridoma H210) anti-hepatitis A immunoglobulin lambda chain variable region, constant region, GP:M87790_1 K.IMIYEVSK.R 1 1.929 0.088 G complementarity-determining regions mRNA, complete cds; anti-hepatitis A; putative. Human transfer valyl-tRNA synthetase GP:M98326_1 L.ASAGVVAVLALAP.A 2 2.453 0.109 G mRNA, 3' end of cds. Human (clone 9F2H) Ig rearranged H- GP:M99595_1 Q.LLESGGGLAQPGGSLR.L 2 2.461 0.306 G chain mRNA V-region, 5' end. Homo sapiens immunoglobulin kappa GP:M99602_1 light chain V region (IGKV) mRNA, partial G.QGTYVEVKR.- 2 2.259 0.118 O cds. Homo sapiens aromatase (aromatase) GP:S41951_1 S.SNQTSSLRFLGYTK.S 2 2.283 0.145 P gene, partial cds. EGD1=enhancer of GAL4 DNA binding [Saccharomyces cerevisiae=yeast, Genomic, 517 nt]; BTF3 homolog; human A.GANKDDTKLQSQLAKLHAVTIDNVAEANF GP:S49596_1 3 3.669 0.145 O BTF3 homolog; Method: conceptual FKDDGK.V translation with partial peptide sequencing; This sequence comes from
Supplementary Table 2 64 Fig. 6. IgVL=anti-Hib capsular polysaccharide immunoglobulin light chain variable GP:S57079_1 region {clone LD21} [human, Genomic, L.LIYRASTR.A 2 2.353 0.167 O 321 nt]; This sequence comes from Fig. 3. RYK=related to receptor tyrosine kinase [human, hepatoma, mRNA, 3068 nt]; GP:S59184_1 R.NDLISHY.A 1 1.806 0.147 P related to receptor tyrosine kinase; This sequence comes from Fig. 1b. anti-colorectal carcinoma heavy chain=glycoprotein CANAG-50 specific IgG1 kappa [human, 19.9 hybridoma, GP:S65761_1 antibody 1116NS19.9, mRNA, 1515 nt]; S.VFIFPPKPK.D 2 2.469 0.179 G glycoprotein CANAG-50 specific IgG1 kappa; Method: conceptual translation with partial peptide sequencing; Th lymphocyte-specific protein 1=47 kda actin binding protein [human, HL60, mRNA, 1039 nt]; 47 kda actin binding IPI:IPI00163660.1 GP:S67783_1 protein; Method: conceptual translation A.EASSDPGAEERELLGPTAQWS.V 2 2.665 0.105 G (93%) with partial peptide sequencing; This sequence comes from Fig. 7B; Insertions of GA and TGT at posit Ig V lambda =IgM light chain [human, chronic idiopathic thrombocytopenia IPI:IPI00017248.1 GP:S71522_1 R.DSSGHRVVFGGGTK.L 2 2.462 0.171 G patient, spleen B-cell hybridoma, (93%) Genomic, 378 nt]; IgM light chain. nicotinic acetylcholine receptor alpha subunit|AChR alpha subunit [human, GP:S77094_1 thymic carcinoma, myasthenia gravis- K.PGPPPMGFHSPLIKHFEVK.S 2 2.291 0.102 P associated thymoma patient 1494/88, mRNA Partial, 1676 nt]. Ig VH=immunoglobulin heavy chain variable region [human, Glanzmann GP:S79246_1 thrombasthenia patient, mRNA Partial, Y.YNTNNLTTDAFDIWGQG.T 2 2.429 0.148 A 378 nt]; This sequence comes from Fig. 4. V kappa III subgroup V-J kappa 2=REV25-2 [human, bone marrow cells, myeloma-associated light chain GP:S83559_1 deposition disease patient, mRNA E.EIILTQSPATLSVSPGER.A 2 2.351 0.226 G Partial, 402 nt]; Ig kappa III chain variable region; This sequence comes from Fig. 2. Human immunoglobulin heavy chain GP:U00518_1 variable region (clone Agamma2-3) F.WSGSDEQGMDV.W 2 2.437 0.168 O mRNA, partial cds. Human immunoglobulin heavy chain GP:U00524_1 variable region (clone Agamma3-3) Y.IYSTGSTTYNPSLQ.S 2 2.966 0.107 O mRNA, partial cds. Human clone Amu52-1 Ig heavy chain GP:U00563_1 V.QLVESGGGLVQPGGSLRLSCAASGITVS.S 2 2.484 0.154 P variable region mRNA, partial cds. Human P-type ATPase ATP7B mRNA, IPI:IPI00216296.1 GP:U03464_1 A.EGTATVLYNPAVISPEELRAAIED.M 2 2.421 0.133 A complete cds. (96%) Human clone OF7K.11 Ig kappa chain V- GP:U04372_1 R.ASQTISTYLNWYQQKPGEAPK.L 2 2.284 0.113 G region mRNA, partial cds. Human tyrosine kinase (HTK) mRNA, IPI:IPI00008310.2 GP:U07695_1 S.PSSLSLAWAVPRAPSGAWLDYEVK.Y 2 2.208 0.158 P complete cds. (94%) Human Burkitt's lymphoma IPI:IPI00004638.1 GP:U07987_1 immunoglobulin IgM heavy chain Fd L.EVQLVESGGNLVQPGGSLR.L 2 2.317 0.231 G (93%) fragment mRNA, partial cds. Human Burkitt's lymphoma IPI:IPI00024135.1 GP:U07990_1 immunoglobulin kappa light chain mRNA, A.PTLLIYAVSNLQDGV.P 2 2.544 0.208 P (97%) partial cds. Human rearranged Ig gamma heavy chain V region (VH6-JH1) mRNA, partial GP:U21250_1 L.TCDISGDSVSSNTAAWNWIRQS.P 2 2.473 0.123 G cds, clone JGpFv3-01 VH; from VH6 family gene and JH1. Human rearranged Ig mu heavy chain V GP:U21256_1 region (VH4) mRNA, partial cds, clone R.HKGGDDLFD.S 1 1.838 0.094 P JMpFv2-07 VH. Human Zn-15 related zinc finger protein IPI:IPI00018294.1 GP:U22377_1 (rlf) mRNA, complete cds; Zn-15 related A.AAVAGAGAEAPAVAGAGDGVETESMV.R 2 2.616 0.100 A (94%) zinc finger protein. GP:U22961_3 Human mRNA clone with similarity to L- Q.EPGRNECFLQHKDDNPNLPR.L 2 2.259 0.200 A IPI:IPI00022434.1
Supplementary Table 2 65 glycerol-3-phosphate:NAD (99%) oxidoreductase and albumin gene sequences; similar to human albumin, Swiss-Prot Accession Number P02768; Method: conceptual translation supplied by author. Human p58 natural killer cell receptor IPI:IPI00019882.1 GP:U24076_1 precursor mRNA, clone cl-42, complete M.SLLFVSMACVGFFLLQGAW.P 2 2.571 0.156 A (96%) cds; p58 NK receptor. Human RP1 and complement C4B IPI:IPI00032258.2 GP:U24578_2 L.QFSLGSKINVKVGGNXKGTLK.V 2 2.792 0.089 G precursor (C4B) genes, partial cds. (93%) Human ribosomal protein L21 mRNA, IPI:IPI00141189.2 GP:U25789_1 K.HSKSRDNFLKRVKXDDQEK.X 2 2.481 0.200 G complete cds. (94%) Caenorhabditis elegans cosmid K05B2, complete sequence; similar to human putative cell growth or differentiation GP:U29379_1 regulator (PIR:A44478,B44478); coded Q.YQLELKKSHKLK.A 2 2.493 0.100 O for by the following C. elegans cDNAs: yk67b4.3, yk67b4.5, yk107g10.3, yk107g10.5, yk478f8.3, yk478f Human CREB-RP (creb-rp) mRNA, R.SQPAFLDAIDRREDTFYVVSFRRGHLLLPA GP:U31903_1 3 3.626 0.115 A complete cds. I.S Human pro-a2 chain of collagen type XI G.TSGGDGPHGPPGERGLPGPQGPNGFPG GP:U32169_1 (COL11A2) gene, complete cds; lacks 2 2.458 0.118 O PKGPL.G alternative exons 6, 7 and 8. Human protein tyrosine phosphatase IPI:IPI00178358.1 GP:U35234_1 N.AVTLQGLKPDTA.Y 1 2.062 0.125 P sigma mRNA, complete cds; HPTPs. (97%) Homo sapiens platelet cGI-PDE mRNA, GP:U36798_1 complete cds; cGMP-inhibited V.LQPLRSSRKLSSALCAGC.L 2 2.619 0.209 G phosphodiesterase. Homo sapiens estrogen regulated LIV-1 GP:U41060_1 protein (LIV-1) mRNA, complete cds; H.EHHSDHNHAASGKNK.R 2 2.292 0.108 A breast cancer. Human metalloprotease/disintegrin/cysteine-rich IPI:IPI00168856.1 GP:U41766_1 protein precursor (MDC9) mRNA, L.LLGLVGPVLGAARP.G 2 2.577 0.124 O (94%) complete cds; Method: conceptual translation supplied by author. Human class I homeoprotein (HOXA9) mRNA, partial cds; fusion partner with nucleoporin NUP98 in acute myeloid IPI:IPI00027131.1 GP:U41813_1 V.ATSAFPAQEPRVFLRSALPAG.R 2 2.547 0.226 O leukaemia t(7;11)(p15;p15) (95%) translocation.homeobox gene in HOXA gene cluster; class I homeoprotein. Human Ig kappa L-chain variable region (B6B7K) mRNA, partial cds; Method: GP:U44792_1 R.ASQSISNYLNWYHQKPGK.A 2 2.279 0.188 G conceptual translation supplied by author. Homo sapiens pyruvate kinase PK-R isoenzyme gene, partial cds; and IPI:IPI00219884.1 GP:U47654_1 T.ESMSIQENISSLQLRSWVSK.S 2 2.583 0.096 P pyruvate kinase PK-L isoenzyme gene, (97%) complete cds. Mus musculus APC-binding protein EB1 IPI:IPI00017596.1 GP:U51196_1 homolog mRNA, complete cds; similar to F.DANYDGKEYDPVAARQGQET.A 2 2.502 0.221 P (96%) human APC-binding protein EB1. Rattus norvegicus zinc finger homeodomain enhancer-binding protein- 1 (Zfhep-1) mRNA, partial cds; DNA- GP:U51583_1 V.DQDGTTKIIINYSLEQPGQLQVVPQ.N 2 2.443 0.175 O binding protein; simialr to human AREB6, ZEB, Nil-2-a, chicken delta EF-1 and hamster BZP. Homo sapiens 130 kD Golgi-localized phosphoprotein (GPP130) mRNA, GP:U55853_1 K.LEAQETLNKGRQD.S 1 1.806 0.099 G complete cds; GPP130; type II Golgi membrane protein. Human mnb protein kinase homolog hp86 (DYRK) mRNA, complete cds; IPI:IPI00182717.1 GP:U58496_1 F.ENLPDGTWNLK.K 2 2.386 0.150 P homolog of Drosophila mnb (minibrain) (93%) protein kinase. Human chromosome 17 unknown GP:U58856_1 G.LAGQHSCELLQLGAPGLG.P 2 3.150 0.124 O product mRNA, complete cds. GP:U59628_1 Human PAX-9 mRNA, partial cds. P.LPQPQGGGVEQPGPQQLPRRR.P 2 2.326 0.102 O Homo sapiens transcription factor LZIP- GP:U59629_1 I.EISNKTSSSSTGILVLLVSFCLLLVP.A 2 2.446 0.121 A alpha gene, complete cds. Human receptor protein tyrosine IPI:IPI00182339.1 GP:U60289_1 Y.EISVLLTRPGDGGTGRPGPPLISR.T 2 2.285 0.112 O phosphatase psi R-PTP-Psi gene, (96%)
Supplementary Table 2 66 complete cds; R-PTP-Psi. Human carboxylesterase (hCE-2) mRNA, IPI:IPI00179471.1 GP:U60553_1 complete cds; Method: conceptual R.NGNPNGEGLPHWPL.F 1 2.148 0.087 G (98%) translation supplied by author. Human rheumatoid arthritis synovium GP:U64485_1 immunoglobulin heavy chain variable -.DMQLLESGGGLVQPGGSLR.L 2 2.236 0.306 G region mRNA, partial cds. Human rheumatoid arthritis synovium GP:U64505_1 immunoglobulin heavy chain variable W.FRQAPGKGLEWVSYISGDGETT.H 2 2.472 0.146 G region mRNA, partial cds. Human SWI/SNF complex 155 KDa subunit (BAF155) mRNA, complete cds; a core subunit presents in all human GP:U66615_1 SWI/SNF complexes purified so far; I.PTVAANIHPSGSGPTP.P 1 2.176 0.239 G similar to subunit BAF170 and yeast SWI3 protein; contains a region similar to DNA binding domain of myb and a Mus musculus type II collagen antibody heavy chain variable region mRNA, GP:U69538_1 Q.QSGAELAKPGTSVK.M 1 1.812 0.084 A partial cds; anti-mouse and anti-human type II collagen antibody. Homo sapiens integrin binding protein Del-1 (Del1) mRNA, complete cds; modular extracellular matrix protein; IPI:IPI00218947.1 GP:U70312_1 contains three EGF-like repeats and two G.GTCEISEAYRGDTFIGYVCKCPR.G 2 2.203 0.175 A (97%) discoidin I-like domains; the second EGF-like repeat contains an RGD integrin binding motif that appe Human ataxin-2 (SCA2) mRNA, GP:U70323_1 F.IENSSSNCTSGSSKPNSPSISPS.I 2 2.468 0.115 G complete cds. Human neuropeptide Y receptor type 2 IPI:IPI00026065.1 GP:U76254_1 W.SKLKSHVSPGAANDHYHQRRQKTTK.M 2 2.518 0.170 A gene, complete cds. (95%) Homo sapiens clone BY-4HC IgM heavy GP:U77371_1 R.IDWDDDKFYTTSLK.T 2 2.221 0.124 G chain variable region mRNA, partial cds. Human clone 5A25 immunoglobulin IPI:IPI00018563.3 GP:U77557_1 variable region (VH5-D-JH5) gene, -.EVQLVQSGAEVKKPGESLE.I 2 3.797 0.111 G (96%) partial cds. Human hTRIP (hTRIP) mRNA, complete IPI:IPI00025188.1 GP:U77845_1 E.ELVGAFPIFVRNAILGQKQPK.R 2 2.497 0.186 G cds. (96%) Human immunoglobulin heavy chain GP:U80135_1 variable region (V4-34) gene, partial cds; G.EINHSGSTNYNPTLKSR.V 2 2.448 0.206 A Ig VH4 heavy chain. Human gamma-aminobutyric acid transaminase mRNA, partial cds; GABA- IPI:IPI00098592.1 GP:U80226_1 P.SSSPWPACPAPMK.T 2 2.250 0.141 O T; GABA transaminase; (97%) aminotransferase. Homo sapiens CAGF28 mRNA, partial IPI:IPI00185180.1 GP:U80735_1 A.NVPPVPGNILPPEVRGNLMAAGQN.L 2 2.765 0.098 O, P cds; contains glutamine repeats. (93%) Homo sapiens CTG26 alternate open GP:U80761_1 reading frame mRNA, complete cds; G.FSSSFSASFSFSFSSFSSWLLR.G 2 2.297 0.186 G cysteine rich. Human scavenger receptor cysteine rich Sp alpha mRNA, complete cds; secreted protein; contains three scavenger GP:U82812_1 G.RLEVLHKGVWGSV.C 2 2.993 0.128 G receptor cysteine rich (SRCR) domains; group B member; similar to CD6, CD5, M130, and WC1. Human alpha II spectrin mRNA, complete cds; fodrin, calspectin; cytoskeletal protein; calculated MW IPI:IPI00015786.1 GP:U83867_1 L.ASEDYGKDLASVNNLLKKH.Q 2 2.607 0.092 A 285,094, estimated PI 5.18; brain and (96%) muscle specific insert 2 adds five residues in repeat unit 15 at codon 1587. Homo sapiens isolate VAN IgM heavy GP:U84195_1 chain VH1 region precursor (VH1-18) T.XVHSQVQLVQSGVEV.K 1 2.040 0.152 A gene, partial cds. Homo sapiens brain secretory protein IPI:IPI00008553.1 GP:U85946_1 hSec10p (HSEC10) mRNA, complete L.DVVQQANTIFHLFDKQFNDH.L 2 2.451 0.243 G (97%) cds; similar to S. cerevisiae Sec10p. IPI:IPI00066094.1 GP:U88153_1 Homo sapiens p160 mRNA, partial cds. A.PPSHRKGDSNANSDVCPAALRGLSR.T 2 2.211 0.107 A (91%) Human polyhomeotic 1 homolog (HPH1) GP:U89277_1 A.GGGSGNSIPGSMGPGGGGQAHGGLGQ.L 2 2.461 0.115 A mRNA, partial cds. Human 9-cis-retinol specific IPI:IPI00023319.1 GP:U89717_1 dehydrogenase mRNA, complete cds; L.ASCLTPSGAEDLQGVASSGFNTTLL.D 2 2.546 0.119 O (97%) short chain alcohol dehydrogenase.
Supplementary Table 2 67 Human unknown protein (BT3.2) mRNA, GP:U90144_1 complete cds; similar to butyrophilin S.VIMRGGSGEGVSCIIRNSLLGLEKTA.S 2 2.486 0.223 A protein. Human L1 element L1.8 p40 and putative GP:U93564_2 G.RINIMKMAILPK.V 2 2.241 0.106 A 96 (0%) p150 genes, complete cds; ORF2. Homo sapiens N-RAP gene, partial cds; nebulin-related anchoring protein; found GP:U96486_1 at myotendon junctions in skeletal D.ALPFQAAKASGEIISDYKYKEAF.E 3 3.864 0.093 O muscle and at intercalated disks in heart muscle. Mus musculus serine proteinase inhibitor 6 (SPI6) mRNA, complete cds; spi6; GP:U96700_1 similar to human granzyme B inhibitor, N.VCYSPASISSALA.M 1 2.015 0.109 O proteinase inhibitor 9; member of ovalbumin group of serpin superfamily. Mus musculus homolog of human GP:U97045_1 Werners syndrome protein (WRN) E.KLKCAETWSLNGLVKHVLGK.Q 2 2.242 0.107 G mRNA, complete cds. Human messenger RNA for beta-globin; IPI:IPI00030971.1 GP:V00500_1 K.SAVTAXWGK.V 1 1.895 0.259 P reading frame (beta-globin). (98%) Human germline DNA of kappa deleting element (kde) mediating deletion of kappa constant gene region in lambda GP:X03957_1 Q.QVGSAHCGSPSGSPGRLLMSL.Q 2 2.512 0.188 G light chain producing cells; long open reading frame; Protein sequence is in conflict with the conceptual translation. Human mRNA for apolipoprotein B-100 K.KITEVALMGDLSCDTKEERKIKGVISIPRLQ IPI:IPI00022229.1 GP:X04714_1 3 3.519 0.132 G (apoB-100). AEAR.S (97%) Human germline T-cell receptor delta GP:X15261_1 V.ISPVRTEDSATYY.C 1 2.297 0.130 G chain V gene segment. M.musculus mRNA for factor XII; GP:X99571_1 putative, based on homology with human L.EQCQTPTFAPLVVPES.Q 1 2.095 0.098 G factor XI. Human mRNA for B-lymphocyte CR2- IPI:IPI00021699.1 GP:Y00649_1 receptor (for complement factor C3d and L.NGRHIGNSLANVSY.G 1 2.494 0.141 G, O, P (98%) Epstein-Barr virus). Homo sapiens mRNA for zinc finger IPI:IPI00020117.1 GP:Y12726_1 F.FVSMSETIKYND.D 2 2.578 0.167 P protein 161. (96%) Homo sapiens mRNA for B-cell GP:Y13620_1 S.GGPQQNPGVLDGPQKKPEGPIQA.M 2 2.551 0.222 P CLL/lymphoma 9 (BCL9 gene). Homo sapiens mRNA for chimaeric transcript of collagen type 1 alpha 1 and GP:Y15912_1 G.PSGASGPAGPRGDPIPEELYESRR.N 2 2.335 0.194 A platelet derived growth factor beta, 201 bp. Homo sapiens mRNA for chimaeric transcript of collagen type 1 alpha 1 and GP:Y15915_1 S.GLQGPPGPPGDPIPEELYEML.S 2 2.459 0.154 A platelet derived growth factor beta, 1068 bp. Homo sapiens mRNA for immunoglobulin A.DTAVYYCARGDHLGVVVTGMSYYYAMDV GP:Y17927_1 2 2.482 0.147 G heavy chain, JK3H. W.G Homo sapiens mRNA for immunoglobulin IPI:IPI00053682.1 GP:Y17939_1 T.RPYTFGQGTK.L 2 2.336 0.110 G light chain, JK19L. (94%) Homo sapiens mRNA for immunoglobulin GP:Y18120_1 S.GGGLVQPGGSLTLSCAASGFTFTSY.A 2 2.463 0.128 P heavy chain variable region. Homo sapiens mRNA for partial aczonin GP:Y19188_1 M.HRKQELDSSHPPKQSGRPPDPGR.P 3 3.513 0.113 G (acz gene). Homo sapiens rearranged Ig kappa GP:Z18842_1 E.DFATYFCQQANSLPPTFGGGTKV.E 2 2.633 0.221 P region V-domain cDNA. Homo sapiens PRM1, PRM2, PRM3, GP:Z46940_3 K.KLMACVSQDNFSLSSAG.E 2 2.513 0.144 A TNP2 and SOCS-1 genes. C.tentans mRNA for hrp45 protein; homologous to Drosophila melanogaster GP:Z54163_1 SRp55 (x58720) and B52 (x62599) and R.ESRSKSRGSRSKSPAEK.K 2 2.249 0.138 A human SF2 (m69040) and ASF (m72909) splicing factors. Caenorhabditis elegans cosmid F36H2, complete sequence; Similarity to Human complement factor H precursor GP:Z81078_2 (SW:CFAH_HUMAN), contains similarity N.QNCAAMDTPNHGTFSYSVAGSFTTGTI.V 2 2.678 0.199 P to Pfam domain: PF00084 (Sushi domain (SCR repeat)), Score=427.8, E- value=3.1e-125, N=23. Human DNA sequence from clone CTA- 941F9 on chromosome 22q13 Contains GP:Z95331_1 E.PRDLLLTVKMDLSR.H 2 2.232 0.157 A the 3' end of the FBLN1 gene for Fibulin 1 isoforms B, C and D, the first exon of
Supplementary Table 2 68 the gene for a novel protein (the ortholog of mouse brain protein E46), ESTs, STSs, GSSs and two pu Human DNA sequence from clone ICRF6c-CF0811 on chromosome 6. Contains the 3' end of the DAXX gene for GP:Z97184_7 death-associated protein 6 (Fas-binding A.LPPQAPVSVWDEEEDGAVF.T 2 2.700 0.094 O protein), the ZNF297 gene for zinc finger protein 297 (BING1), the TAPBP gene for TAP-binding protein (tapas Human DNA sequence from clone RP1- 309I22 on chromosome 22q12.1-13.2 Contains the 3' part of the TIMP3 ( tissue GP:Z98256_2 inhibitor of metalloproteinase 3 (Sorsby V.SVVTLLLAFSADPSSQTSSWSASMPT.A 2 2.527 0.145 P fundus dystrophy, pseudoinflammatory)), a pseudogene (K222), part of the SYN3 gene for synapsin II Homo sapiens potential LAG1 interactor GPN:AF212044_1 Y.LSILISLQ.I 1 2.290 0.142 P mRNA, partial cds. Homo sapiens VPS10 domain receptor IPI:IPI00103597.2 GPN:AF284756_1 SorCS mRNA, complete cds; contains L.AGAGLLILCAPGVCGGGSCCPSPH.P 2 2.424 0.250 G (97%) VPS10 domain. Homo sapiens clone pp7683 unknown GPN:AF289593_1 P.FCSLLSWAVPSWDK.V 2 2.447 0.109 P mRNA. Homo sapiens nuclear receptor- interacting factor (NRIF4) mRNA, IPI:IPI00220069.1 GPN:AF308819_1 K.TQGAVAR.M 1 1.890 0.090 A complete cds; contains five putative zinc- (94%) finger structures. Homo sapiens pp13671 mRNA, GPN:AF318336_1 G.PPKSKAEKIKRSPMDKVLRFA.R 2 2.421 0.148 A complete cds. Homo sapiens four-span transmembrane GPN:AF350501_1 protein 2 (4SPAN2) mRNA, complete G.LPTETTVLGTVQILCCLLISSLGAI.L 2 2.508 0.149 A cds. Homo sapiens HCV-associated K.GLEWIGEINHSGSSNYNPSLKSRVIISVDT GPN:AF372845_1 immunoglobulin heavy chain variable 3 3.722 0.152 P SKNQFSLQL.S region mRNA, partial cds. Homo sapiens ankyrin repeat domain- GPN:AF403033_1 containing SOCS box protein Asb-15 L.DPLNCLLVAVRANNYEI.V 2 2.449 0.115 P mRNA, partial cds. Homo sapiens very large G protein- IPI:IPI00165934.2 GPN:AF435925_1 coupled receptor 1b (VLGR1) mRNA, A.FADVSVK.F 1 1.845 0.083 P (97%) complete cds. Homo sapiens G-protein-coupled IPI:IPI00102804.1 GPN:AF439409_1 receptor kinase 7 (GRK7) mRNA, GRK7- I.NFPRLEAGLIEPPFVPDPSVVYAK.D 2 2.311 0.233 O (92%) S allele, complete cds. Desmodus rotundus von Willebrand D.VLRRVREIRYQGGNSTNTGLALQYVSEHS GPN:AF447550_1 factor (vWF) gene, partial cds; similar to 2 2.436 0.183 A F.S Homo sapiens von Willebrand factor. Homo sapiens clone 12 anti-hepatitis B GPN:AF455922_1 surface antigen immunoglobulin heavy K.NTVYLQMSSLR.A 1 1.847 0.105 G chain variable region mRNA, partial cds. Homo sapiens IGLV gene for GPN:AJ426384_1 immunoglobulin lambda light chain N.TVNWYQQFPGTAPK.L 2 2.423 0.165 O variable region, isolate VLPG6P. Homo sapiens IGLV gene for GPN:AJ426389_1 immunoglobulin lambda light chain K.LLIHEVTNRPSGVPDR.F 2 2.353 0.230 G variable region, isolate VLPG11P. Human DNA sequence from clone RP11- 165P4 on chromosome 9q34.11-34.13 Contains the gene for the possible GPN:AL137068_1 ortholog of a mouse antigen (Ma2a8), the L.QEQHEVNASLQQ.T 2 2.609 0.120 A CEP1 gene for centrosomal protein 1, the RAB14 gene for a member of the RAS oncogene family and a CpG isl Human DNA sequence from clone RP11- 352G14 on chromosome 6. Contains the SLC17A4 gene for solute carrier family GPN:AL391194_1 17 (sodium phosphate) member 4, the 3' V.LFPSVILVSLPWVRSS.H 2 2.692 0.090 P end of the SLC17A1 gene for solute carrier family 17 (sodium phosphate) member 1, ESTs, STSs and GSS Homo sapiens ALC (ALC) mRNA, IPI:IPI00166201.1 GPN:AY013707_1 K.LRDSLYFGIEPVVHVSGLESL.V 2 2.537 0.197 G complete cds. (95%) Homo sapiens keratin protein K6irs (KRT6) mRNA, complete cds; type II GPN:AY033495_1 N.SVSISVISSTNAGAGGA.G 2 2.465 0.229 O intermediate filament protein; expressed in the inner root sheath of hair follicles. Supplementary Table 2 69 Homo sapiens MCLL011 immunoglobulin IPI:IPI00053682.1 GPN:AY043105_1 light chain variable region mRNA, partial P.PTWTFGQGTK.V 2 2.442 0.220 G (95%) cds. Homo sapiens mandaselin short form IPI:IPI00179174.1 GPN:AY048774_1 S.WYGNPQFDGK.Y 2 2.312 0.121 G mRNA, complete cds. (98%) Mus musculus helicase DDX32 mRNA, GPN:AY065980_1 complete cds; similar to Homo sapiens A.HKQTAVQLALRVADEMDVNIGHEVG.Y 2 2.495 0.165 G DDX32. Homo sapiens, hypothetical protein GPN:BC019332_1 STRAIT11499, clone MGC:972 S.LLRDVPLADPGL.D 1 2.114 0.176 G IMAGE:3541914, mRNA, complete cds. Homo sapiens, clone MGC:24842 GPN:BC019585_1 L.GPLLVAVSG.T 1 2.106 0.084 P IMAGE:4180879, mRNA, complete cds. Homo sapiens, clone MGC:31889 IPI:IPI00006713.1 GPN:BC020215_1 L.KSNPSENEEKEAQSQLIKS.D 2 2.604 0.124 O IMAGE:3678014, mRNA, complete cds. (95%) Homo sapiens, clone MGC:32124 IPI:IPI00102928.1 GPN:BC020263_1 P.GDPGLYLALLGR.V 2 2.268 0.102 P IMAGE:4877960, mRNA, complete cds. (91%) Homo sapiens, clone MGC:9489 GPN:BC020265_1 I.ADNPVENII.R 1 2.233 0.146 A IMAGE:3922829, mRNA, complete cds. glutamate dehydrogenase (NAD(P)+) G.VFHGIENFINQASYMSILGMTPGFRDKTFV IPI:IPI00027146.1 PIR1:A53719 2 2.420 0.205 A (EC 1.4.1.3) 2 precursor - human .V (94%) protein-tyrosine-phosphatase (EC IPI:IPI00003630.1 PIR1:A57064 3.1.3.48), receptor type O precursor - G.DPELSCCDSSTISF.I 1 2.255 0.099 O (97%) human orphan receptor TR2, splice form TR2-11 IPI:IPI00019051.1 PIR1:B36738 L.SRLLLRLPALRLMNATITEEL.F 2 2.508 0.133 P - human (95%) IPI:IPI00145893.1 PIR1:I38344 titin, cardiac muscle [validated] - human N.SCGKKEYTIVVKVLDTPGPPI.N 2 2.458 0.182 P (97%) PIR1:I38977 TAR DNA-binding protein-43 - human A.SNAGSGSGFNGGFGSSMDSKSSGWGM.- 2 2.418 0.154 A thyrotropin receptor precursor, short IPI:IPI00028642.1 PIR1:JC1319 G.PSLLLPLGRKSFSFETQK.A 2 2.344 0.173 P splice form - human (93%) protein disulfide-isomerase (EC 5.3.4.1) V.AYTEPKMTSGKIKKFIQGNIFGICPHMTED IPI:IPI00025252.1 PIR1:S55507 3 3.658 0.112 O ER60 precursor - human NK.D (95%) bcr (breakpoint cluster region) protein, PIR1:TVHUA2 P.HLSSKGRGSRDALVSGALVSTK.R 2 2.267 0.116 P splice form 3 - human (fragment) G.AGAAAAAAAAAAGGPSGTATGSAPPGEL PIR1:TVHUJD transforming protein jun-D - human 2 2.442 0.223 O APAAAA.P HIV-EP2 enhancer-binding protein - R.SGWHHGPPAVLPPLQQEDPGKQVAGPC PIR1:WMHUE2 3 3.528 0.115 O human PPLSSGPLHL.A amidophosphoribosyltransferase (EC IPI:IPI00029534.1 PIR2:A53342 R.EVLPGEIVE.I 1 2.008 0.090 A, P 2.4.2.14) precursor - human (98%) IPI:IPI00220683.1 PIR2:A54601 RNA-binding protein AUF1 - human A.VGAAAGEQEGAMVAATQGAAAAR.E 2 2.268 0.129 P (96%) adducin alpha splice form 2 - human PIR2:A56696 S.DCTETIEGLELTEQTFSPAK.S 3 3.580 0.087 O (fragment) IPI:IPI00096898.1 PIR2:A57644 Na+/H+-exchanging protein 2 - human G.NSSDSDMDGTTVL.N 1 2.019 0.137 G (92%) cytochrome P450 2F1, truncated splice PIR2:B36036 L.GAWAAPTHLPELQVPER.P 2 2.271 0.139 G form - human Ig kappa chain V region, rheumatoid IPI:IPI00026195.1 PIR2:B49002 T.SLNWFQQR.P 2 2.228 0.178 G factor RF antibody - human (fragment) (95%) PIR2:G01973 glioma protein RIG - human H.HANSSCVRNAFWLQITEK.L 2 2.227 0.135 O IPI:IPI00173903.1 PIR2:G02913 sperm CD46 - human (fragment) L.NMPLTRLNQPLQQS.R 2 2.601 0.131 A (96%) transcription initiation factor IIIB 90K IPI:IPI00216075.1 PIR2:I39065 P.HMLLVLSDLLQVNVYVLGKTFL.L 2 2.556 0.137 G chain - human (93%) microtubule-associated protein EB1 PIR2:I52726 S.TQRTAAAPKAGPGV.V 2 2.476 0.125 G [imported] - human PIR2:I52882 autoantigen - human D.IEDATQHLRDILK.L 2 2.219 0.131 G IPI:IPI00010470.1 PIR2:I53735 nerve terminal protein - human E.QLDRVEEGMNHIN.Q 2 3.480 0.131 O (95%) galactosylceramidase (EC 3.2.1.46) IPI:IPI00008790.1 PIR2:I54205 T.TKCDVYIETPDTGGVF.I 2 2.402 0.126 G precursor - human (96%) PIR2:I55593 connexin 37 - human V.REHSTVVGKIWLTVLFIF.R 2 2.581 0.232 A PIR2:I58009 gene ERCC5 protein - human F.LWGKPDLDKISEFCQ.R 2 2.461 0.178 P IPI:IPI00030146.1 PIR2:I59767 lamin-like protein - human (fragment) I.ETQKTLQKT.N 1 2.158 0.174 A (92%) chlordecone reductase homolog (clone IPI:IPI00179294.1 PIR2:I73675 K.SIGVSNFNRSTLEMILNKPGLQVK.P 2 2.366 0.104 P HAKRc) - human (fragment) (98%) pregnancy-specific beta 1-glycoprotein - IPI:IPI00017255.1 PIR2:I77374 S.YPVTLNVLITTK.H 2 2.613 0.083 P human (fragment) (99%) IPI:IPI00020178.1 PIR2:JC4916 signal transducing adaptor - human V.TFPAIGSQAAEQAKASPALVA.K 2 2.422 0.106 A (91%) PIR2:JC5279 translocation protein 1 - human K.SDSEEKSDSEK.K 2 2.328 0.142 P
Supplementary Table 2 70 zinc finger protein KF-1 precursor - IPI:IPI00031299.1 PIR2:JC5392 K.KQPYAQHQPLSNDVPS.- 1 1.907 0.094 G human (96%) Gu/RNA helicase II binding protein - IPI:IPI00183258.1 PIR2:JC5517 T.TNGSSSGSNTSLVSSNSLRESH.S 2 3.061 0.126 O human (91%) Down syndrome critical protein A - IPI:IPI00220555.1 PIR2:JC5698 C.DMFKRSLLAKDLTK.T 2 2.692 0.126 A human (99%) mitochondrial ribosomal protein S7 small PIR2:JC7165 K.LSHKLLEAFH.N 1 1.942 0.089 O chain precursor - human IPI:IPI00029180.1 PIR2:JC7502 choline transporter - human M.AIPAILIGAIGASTDWNQTAY.G 2 2.504 0.149 O (92%) basic helix-loop-helix protein, DEC2 - PIR2:JC7583 A.PFPLLYPGIPAPAAAAAAAAAAAAAA.A 2 2.571 0.204 O, P human PIR2:JE0241 Ig kappa chain Am37 precursor - human T.LTSKADYEKHKVYACEVTHQGLSSPVTK.S 3 3.622 0.272 G Ig lambda chain NIG204 precursor - IPI:IPI00154742.1 PIR2:JE0246 L.TQPPSVSGAPGQGV.T 2 2.530 0.262 G human (92%) carbonic anhydrase-related protein - IPI:IPI00025812.1 PIR2:JE0375 W.AALGAAAH.I 1 2.133 0.087 A human (96%) hepatocellular carcinoma complicating IPI:IPI00025716.1 PIR2:PC4211 hemochromatosis protein - human C.DYLKFLYLNFSAQI.L 2 2.572 0.113 G (95%) (fragment) PIR2:PC4395 mucin 3 - human (fragment) L.DSTTMSVSMPM.E 1 2.013 0.091 A Ig heavy chain V region (clone P1-51) - PIR2:PH1409 A.SDTAIYFCARKVAPAK.V 2 2.314 0.116 A human (fragment) Ig heavy chain V region (clone P1-52) - PIR2:PH1410 Q.GTMVTVSSASTQ.- 2 3.237 0.408 G human (fragment) Ig heavy chain V region (clone P1-54) - IPI:IPI00018563.3 PIR2:PH1414 G.FDPWGQGTLVTVSSASTQ.- 2 4.217 0.436 G human (fragment) (96%) GTP-binding protein G25K - human PIR2:PN0674 V.SADPLVPNVVVTRLTLVSTAPGPLE.L 2 2.439 0.243 G (fragments) Ig heavy chain V-D-J region (RAMOS) - PIR2:PS0341 C.ARVITRASPGTDGRYGMDVWGQGTMV.T 2 2.637 0.117 O, P human (fragment) PIR2:S10352 T-cell receptor beta chain - human C.ASSPGMAYAEAFF.G 1 2.122 0.136 A PIR2:S16506 hypothetical protein - human P.APRGGAAALSAARSPQHPGR.P 1 2.039 0.183 A hypothetical protein, 6.7K (early region PIR2:S20691 A.TSTIMLAKTETKNFQIFMK.H 2 2.235 0.120 O E3) - human adenovirus 41 PIR2:S20779 Ig heavy chain V region - human N.SLFLQMDSLR.P 2 2.388 0.128 G PIR2:S20785 Ig heavy chain V region - human -.QLQLVESGGGLVK.P 2 2.477 0.195 G PIR2:S26792 Ig heavy chain V region - human Y.YDFWSGYFYYYY.M 1 2.319 0.188 O modulator recognition factor 1 - human PIR2:S27962 T.AGPSPMAAGLMHFPPTSFDSALRHRL.C 2 2.446 0.232 A (fragment) dimethylaniline monooxygenase (N- IPI:IPI00219008.1 PIR2:S29125 V.AVIGAGVSGLSSIKCCV.D 2 2.555 0.230 G, O, P oxide-forming) (EC 1.14.13.8) - human (96%) PIR2:S29204 melanotropin receptor - human D.LLVSGTNVLETAVILLL.E 1 2.488 0.143 P phosphoprotein phosphatase (EC IPI:IPI00182189.1 PIR2:S35700 3.1.3.16) 1-gamma-2 catalytic chain - K.KPNATRPVTPPRVASGLNPSIQKASNYR.N 2 2.262 0.116 A (93%) human T-cell receptor alpha chain - human PIR2:S36132 I.VPSQPGDSAVYFCAASANDYKLSFG.A 2 2.401 0.184 A (fragment) PIR2:S37595 mucin JUL10 - human (fragment) T.ASSTRGTAGTLK.V 1 1.819 0.102 G IPI:IPI00023617.1 PIR2:S37648 hypothetical protein p18 - human T.KAQILELLVLEQFLTILPGEIR.T 2 2.263 0.108 O (99%) Ig kappa chain V region - human T.PAPVLFLLLLWLPDTTGEIVLTQSPGTLSLS IPI:IPI00003486.1 PIR2:S38643 2 2.284 0.105 P (fragment) PGER.A (95%) PIR2:S40133 T-cell receptor V-alpha w30 - human L.RLQEGESSSLNCSCTVSGLRGLF.W 2 2.513 0.122 G IPI:IPI00003473.1 PIR2:S40321 Ig kappa chain - human R.IEFPYTFGQGTK.L 2 2.423 0.277 G (92%) PIR2:S40325 Ig kappa chain - human G.QLVLTQSPVTLSLSPGER.A 2 2.460 0.218 P PIR2:S40335 Ig kappa chain V-J-C region - human F.AASTLHSGVPSR.F 2 2.298 0.179 G PIR2:S40338 Ig kappa chain - human P.YTFGEGTK.L 1 1.823 0.108 G, P PIR2:S40353 Ig kappa chain V-J-C region - human R.ASQGIGNDLGWYQQK.P 2 2.471 0.346 G PIR2:S46396 Ig lambda chain V region - human I.SCTGTSSDVGAYKYVSWYQQ.H 2 2.584 0.138 O PIR2:S56749 F11 platelet antigen - human (fragments) I.VLVFDKDXTIYLNXYLTD.X 2 2.557 0.190 A Ig light chain V-J region - human PIR2:S57428 Q.PPSVSGTPGQGVTISCSGSR.S 2 2.251 0.170 O (fragment) PIR2:S58296 hypothetical protein - human (fragment) S.KQSLILILTQSLQK.A 2 2.314 0.144 O PIR2:S59960 proline rich protein (clone B4-2) - human A.QEVPGPAAALAPSPAAAAGTEGASPDL.A 2 2.405 0.135 O PIR2:S60062 hevin precursor - human E.KSSVLKSKEESHEQSAEQG.K 2 3.166 0.191 G Ig heavy chain V region (clone RFSJ5H), PIR2:S69897 Q.SPGKGLDWVAAISSDGNNQY.Y 2 2.535 0.318 O, P rheumatoid factor - human probable transmembrane protein TMC - IPI:IPI00102885.1 PIR2:S70029 Y.FSAVMVRLMLVLAPVMCI.L 1 2.142 0.112 O human (98%) PIR2:S71315 deoxyguanosine kinase (EC 2.7.1.113) P.LEGVSSSRGLHAGCGPR.R 2 2.333 0.148 P IPI:IPI00221317.1
Supplementary Table 2 71 precursor - human (97%) PIR2:S72612 RNA helicase II - human (fragments) L.VTFLFPIQTFSF.A 1 2.099 0.210 P ribonuclease 6 (EC 3.1.27.-) precursor - IPI:IPI00216575.1 PIR2:S78046 A.ALRGRLLGCLCLALLCLGGADK.R 2 2.311 0.241 O human (98%) hypothetical protein KIAA0404 - human PIR2:T00051 A.HFFSVGASGGPQAAAPEAPSLHL.Q 2 2.401 0.185 A (fragment) hypothetical protein KIAA0449 - human IPI:IPI00005368.1 PIR2:T00066 W.NVDNFTPIGEIKGHDSPINAI.C 2 2.422 0.122 A (fragment) (92%) PIR2:T00084 hypothetical protein KIAA0512 - human T.GAVPKGGGKGVTRSRNGGKGKGK.K 2 2.520 0.130 A hypothetical protein KIAA0467 - human K.KLQLLTYNWAPDLGAALGRALVRLVQWQ. PIR2:T00093 3 3.549 0.143 G (fragment) N hypothetical protein KIAA0597 - human PIR2:T00268 I.TTIVGYILLAITLIICHGLATLV.K 2 2.473 0.125 G (fragment) IPI:IPI00006096.1 PIR2:T00344 hypothetical protein KIAA0586 - human K.PNIAIVEMKSEK.K 2 2.427 0.100 G (92%) PIR2:T00387 KIAA0622 protein - human (fragment) W.EEHFKTILLLLLETLG.D 2 2.824 0.088 P PIR2:T00492 hypothetical protein R29144_1 - human F.DDTPAAARHRARA.H 1 2.014 0.092 A IPI:IPI00012061.1 PIR2:T01437 hypothetical protein R34001_1 - human T.APCLTSLASCVPASSV.L 1 2.072 0.105 G (94%) proline-rich protein DJ430N08.2 - human PIR2:T02436 E.LVDNAR.D 1 1.941 0.151 O, P (fragment) adenosylhomocysteinase (EC 3.3.1.1) IPI:IPI00182938.1 PIR2:T08681 L.RHRGGSRR.G 1 2.062 0.088 O DKFZp564A1523 - human (fragment) (91%) hypothetical protein DKFZp566D193.1 - PIR2:T08723 V.SASTFGTSCLRQEAAAEGRPVVRFDK.I 2 2.362 0.149 P human (fragment) hypothetical protein DKFZp564O2082.1 - PIR2:T12485 Y.INERNAKFNKKAER.F 2 2.234 0.168 A human hypothetical protein DKFZp434A062.1 - PIR2:T12504 R.ACPRSLSPPWHAPLCPHT.L 1 1.921 0.109 A human (fragment) hypothetical protein DKFZp434I153.1 - PIR2:T12521 A.LDTLVICLEDFDPGVKEAAAWALR.Y 2 2.312 0.142 O human hypothetical protein DKFZp434J193.1 - IPI:IPI00182035.1 PIR2:T12522 L.EPATIPENTQTVVPQLHRVS.L 2 2.413 0.104 O human (fragment) (99%) hypothetical protein DKFZp434I116.1 - V.TYVELCDLASPTALLIMRTVLDLIVEDLQST IPI:IPI00036742.1 PIR2:T17232 3 3.881 0.163 O human (fragment) SED.K (92%) hypothetical protein DKFZp434N231.1 - PIR2:T17269 N.SKGGGNQVSLLNIMMDLKK.C 2 2.504 0.086 A human (fragment) hypothetical protein DKFZp434B0335.1 - IPI:IPI00181437.1 PIR2:T17271 D.QLFASISIGACYQVWA.V 2 2.416 0.190 A human (92%) hypothetical protein DKFZp434B0717.1 - IPI:IPI00182372.1 PIR2:T42668 H.ESKVLRPATMVRVNATCRFEEIV.I 2 2.418 0.141 A human (fragment) (99%) hypothetical protein DKFZp434D0917.1 - IPI:IPI00004339.1 PIR2:T43446 S.SQIQVVGNVGRLHGV.T 2 2.415 0.145 P human (fragments) (95%) hypothetical protein DKFZp434E2118.1 - IPI:IPI00004299.1 PIR2:T43452 T.VAVVNRRGQVTGK.I 2 2.689 0.083 A, O human (fragment) (98%) probable phosphodiesterase I (EC IPI:IPI00174809.1 PIR2:T43461 A.IVKPQPAVHQHSSSSSVS.S 2 2.553 0.215 A 3.1.4.1) - human (fragment) (91%) mucin MUC5B, tracheobronchial PIR2:T45025 T.LGTATTGGPRQSAGSTEPTVPGV.A 2 2.792 0.255 G [imported] - human (fragment) hypothetical protein c316G12.2 IPI:IPI00011693.1 PIR2:T45061 E.RGGASSSCCEEEQTQGRGAEAR.A 2 2.451 0.167 P [imported] - human (94%) hypothetical protein DKFZp761I2124.1 - IPI:IPI00010953.2 PIR2:T46262 Q.AQHQKTFSVSLQKQNKMKFGKNMYINR.D 2 2.340 0.209 P human (fragment) (94%) hypothetical protein DKFZp434D0513.1 - PIR2:T46330 E.ETPMSIDCLYTNTTHLEVNSRV.D 2 2.623 0.086 G human (fragment) probable tyrosine kinase IPI:IPI00027257.1 PIR2:T46362 R.ATVKKEFGGGHIKDELFGTVK.D 2 2.326 0.112 G DKFZp434O0516.1 [similarity] - human (96%) hypothetical protein DKFZp434M1819.1 - PIR2:T46380 N.INLDTETSPCVAILR.K 2 2.448 0.106 O human (fragment) hypothetical protein DKFZp434M0519.1 - PIR2:T46382 A.GEGAGPRAEAGPSRQV.R 1 2.328 0.091 G human (fragment) hypothetical protein DKFZp434K0920.1 - PIR2:T46397 I.TVCPSPSLIPGP.P 1 2.063 0.117 P human hypothetical protein DKFZp434C0923.1 - PIR2:T46415 G.SSPEPLEGACPGHLNVGL.L 2 2.833 0.088 P human hypothetical protein DKFZp434K1323.1 - K.PEPEDDAEEGLGGLPSNISSVSSLLLFNTT PIR2:T46417 3 3.582 0.169 O human (fragment) ENL.Y hypothetical protein DKFZp434J212.1 - IPI:IPI00014303.1 PIR2:T46454 L.RCGHKSLPTPPRQPEQKV.L 2 2.650 0.137 P human (94%) hypothetical protein DKFZp547M236.1 - IPI:IPI00184935.1 PIR2:T50628 G.KIIATLHIK.Y 1 1.856 0.154 P human (98%) laminin receptor processed pseudogene PIR4:JC6530 T.ERATQDWSAAPTAEATQWVGAT.T 2 3.011 0.201 P LAMRL5 - human PIR4:S09612 hypothetical XrepBE protein - human A.SAATAALS.S 1 2.172 0.121 P
Supplementary Table 2 72 Q15777 homo sapiens (human). fetal SW:239F_HUMAN Q.GKVTITVDEYSSNPTQA.F 2 2.686 0.094 G brain protein 239 (239fb). 10/2001 Q14738 h serine/threonine protein phosphatase 2a, 56 kda regulatory IPI:IPI00219544.1 SW:2A5D_HUMAN subunit, delta isoform (pp2a, b subunit, b' E.SSLTEPVIVGLLKF.W 1 2.127 0.236 O (99%) delta isoform) (pp2a, b subunit, b56 delta isoform) (pp2a, b subunit, pr61 d P41595 homo sapiens (human). 5- IPI:IPI00015134.1 SW:5H2B_HUMAN hydroxytryptamine 2b receptor (5-ht-2b) I.LMVIIPTIGGNTLVILAVSLEK.K 2 2.254 0.116 A (96%) (serotonin receptor). 10/2001 P34969 homo sapiens (human). 5- IPI:IPI00003048.1 SW:5H7_HUMAN hydroxytryptamine 7 receptor (5-ht-7) (5- V.ERTFLWLGYANSLINPFIYAFFNRDLR.T 3 3.549 0.221 A (94%) ht-x) (serotonin receptor) (5ht7). 5/2000 O43747 homo sapiens (human). adapter- related protein complex 1 gamma 1 subunit (gamma-adaptin) (golgi adaptor IPI:IPI00217704.1 SW:A1G1_HUMAN L.DSCEPEFKADCAS.G 1 2.182 0.106 P ha1/ap1 adaptin gamma subunit) (93%) (clathrin assembly protein complex 1 gamma larg Q9nti2 homo sapiens (human). potential IPI:IPI00018132.1 SW:A8A2_HUMAN phospholipid-transporting atpase ib (ec Q.EEHGAVSQEEVIR.A 2 2.466 0.129 O (98%) 3.6.3.13) (ml-1) (fragment). 10/2001 SW:AA1R_HUMA P30542 homo sapiens (human). V.ADVAVGALVIPLAILINIGP.Q 2 2.408 0.115 O N adenosine a1 receptor. 11/1997 P35609 homo sapiens (human). alpha- SW:AAC2_HUMA actinin 2 (alpha actinin skeletal muscle IPI:IPI00019884.1 I.SMGYDLGEAEF.A 1 2.070 0.113 P N isoform 2) (f-actin cross linking protein). (96%) 10/2001 O43707 homo sapiens (human). alpha- SW:AAC4_HUMA IPI:IPI00013808.1 actinin 4 (non-muscle alpha-actinin 4) (f- S.KWEKVQQLVPKRDHALLEEQSK.Q 2 2.313 0.109 O N (98%) actin cross linking protein). 10/2001 O95342 homo sapiens (human). bile salt IPI:IPI00218649.1 SW:AB11_HUMAN export pump (atp-binding cassette, sub- G.FESDKSYNNDK.K 2 2.319 0.120 A (98%) family b, member 11). 10/2001 O95704 homo sapiens (human). amyloid beta a4 precursor protein-binding family IPI:IPI00032785.1 SW:ABB3_HUMAN L.HGLCAQILSER.V 2 2.416 0.105 O, P b member 3 (fe65-like protein 2). (93%) 10/2001 O95477 homo sapiens (human). atp- binding cassette, sub-family a, member 1 SW:ABC1_HUMA IPI:IPI00025535.1 (atp-binding cassette transporter 1) (atp- V.FVFLSVFAVVTILQCFL.I 2 2.571 0.125 A N (99%) binding cassette 1) (abc-1) (cholesterol efflux regulatory protein). 10/ Q9np58 homo sapiens (human). atp- binding cassette, sub-family b, member SW:ABC6_HUMA IPI:IPI00014555.1 6, mitochondrial precursor (mitochondrial A.GSLLCAYFVTEQK.L 2 2.694 0.081 O N (94%) abc transporter 3) (mt-abc transporter 3) (abc transporter umat). 10/2001 Q9ubj2 homo sapiens (human). atp- binding cassette, sub-family d, member 2 SW:ABD2_HUMA IPI:IPI00002618.1 (adrenoleukodystrophy related protein) T.HMLNAAADRVKWTRSSAAK.R 2 2.263 0.125 P N (98%) (haldr) (adrenoleukodystrophy-like 1). 10/2001 P19801 homo sapiens (human). amiloride-sensitive amine oxidase [copper-containing] precursor (ec 1.4.3.6) IPI:IPI00182062.1 SW:ABP_HUMAN E.RQAAFRFKRKLPKYL.L 2 2.559 0.206 A (diamine oxidase) (dao) (amiloride- (99%) binding protein) (abp) (histaminase). 10/2001 SW:ACC9_HUMA O60706 homo sapiens (human). IPI:IPI00024278.1 F.GRPILLSSTFRYLADLLGFAGP.L 2 2.557 0.117 O N sulfonylurea receptor 2. 10/2001 (94%) P12821 homo sapiens (human). angiotensin-converting enzyme, somatic IPI:IPI00179732.1 SW:ACE_HUMAN isoform precursor (ec 3.4.15.1) (ace) A.SWAHDTNITAENARRQEEAALLSQEF.A 2 2.458 0.119 O (99%) (dipeptidyl carboxypeptidase i) (kininase ii) (cd143 antigen). 10/2001 P32297 homo sapiens (human). SW:ACH3_HUMA IPI:IPI00217719.1 neuronal acetylcholine receptor protein, H.FEVSMSQLV.K 1 2.135 0.104 A N (93%) alpha-3 chain precursor. 10/2001 SW:ACN1_HUMA O14525 homo sapiens (human). IPI:IPI00022367.1 W.GPAAVLATA.A 1 2.039 0.127 O N astrotactin 1 (fragment). 10/2001 (95%) O00767 homo sapiens (human). acyl-coa SW:ACOD_HUMA desaturase (ec 1.14.99.5) (stearoyl-coa IPI:IPI00013007.2 I.SPRENILVSLGAVGEGFHNYH.H 2 2.885 0.271 A N desaturase) (fatty acid desaturase) (95%) (delta(9)-desaturase). 10/2001 SW:ACPH_HUMA P13798 homo sapiens (human). IPI:IPI00180960.1 V.NYRGSTGFGQDSI.L 1 2.093 0.102 O N acylamino-acid-releasing enzyme (ec (98%) Supplementary Table 2 73 3.4.19.1) (acyl-peptide hydrolase) (aph) (acylaminoacyl-peptidase) (dnf15s2 protein). 10/2001 P42025 homo sapiens (human). beta- SW:ACTY_HUMA centractin (actin-related protein 1b) A.NQPVVIDNGSGVIKAGFAGDQ.I 2 2.636 0.091 A N (arp1b). 10/2001 O75078 homo sapiens (human). adam 11 precursor (a disintegrin and IPI:IPI00219645.1 SW:AD11_HUMAN metalloproteinase domain 11) W.GGLPQLGGPGAPEVTEPSR.L 2 2.208 0.158 P (96%) (metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (mdc). 10/2001 O43184 homo sapiens (human). adam 12 precursor (ec 3.4.24.-) (a disintegrin IPI:IPI00182110.1 SW:AD12_HUMAN V.DISRPLNGLNVPQPQSTQR.V 2 2.395 0.158 G and metalloproteinase domain 12) (98%) (meltrin alpha). 10/2001 Q9p0k1 homo sapiens (human). adam 22 precursor (a disintegrin and metalloproteinase domain 22) IPI:IPI00220632.1 SW:AD22_HUMAN R.PRSNSTETLSPAKSPSSSTGSIASSR.K 2 2.489 0.266 P (metalloproteinase-like, disintegrin-like, (94%) and cysteine-rich protein 2) (metalloproteinase-di R.QLPQGDYVKK.P 2 2.235 0.143 Q9ukq2 homo sapiens (human). adam 28 precursor (ec 3.4.24.-) (a disintegrin IPI:IPI00029097.1 SW:AD28_HUMAN and metalloproteinase domain 28) G.MFHDDYSCKCPSTICVMDKAL.S 2 2.839 0.172 A (96%) (metalloproteinase-like, disintegrin-like, and cysteine- rich protein-l) (mdc-l P35612 homo sapiens (human). beta SW:ADDB_HUMA IPI:IPI00181921.1 adducin (erythrocyte adducin beta S.SSGMPIRIENPNQFVPLY.T 2 2.889 0.132 A N (99%) subunit). 10/2001 P22570 homo sapiens (human). nadph:adrenodoxin oxidoreductase, SW:ADRO_HUMA IPI:IPI00026958.1 mitochondrial precursor (ec 1.18.1.2) P.DLSCDTAVILGQG.N 2 3.461 0.185 G, O, P N (93%) (adrenodoxin reductase) (ar) (ferredoxin- nadp(+) reductase). 10/2001 P51825 homo sapiens (human). af-4 SW:AF4_HUMAN protein (proto-oncogene af4) (fel protein). P.AKDNVEDRTPEHFALV.P 2 2.517 0.113 A 10/2001 V.TDSAPERELSPLISLPSPVPPLS.P 2 2.458 0.162 Q13725 homo sapiens (human). type-1b SW:AG2S_HUMA IPI:IPI00015022.1 angiotensin ii receptor (at1b) (at1br). L.TKNILGSCFPF.L 1 2.225 0.150 P N (91%) 10/2001 O43918 homo sapiens (human). SW:AIRE_HUMAN autoimmune regulator (apeced protein). L.LHALADHDVVPEDKFQETLHL.K 2 2.604 0.128 P 10/2001 Q9y2d5 homo sapiens (human). a-kinase SW:AKA2_HUMAN anchor protein 2 (protein kinase a F.EPPQVSSPVQEK.R 2 2.238 0.131 A anchoring protein 2) (prka2). 10/2001 Q13023 homo sapiens (human). a- kinase anchor protein 6 (protein kinase a IPI:IPI00011442.1 SW:AKA6_HUMAN anchoring protein 6) (prka6) (a-kinase L.SLLSHSSSIESLS.P 2 2.627 0.092 G (91%) anchor protein 100 kda) (akap 100) (makap). 10/2001 Q02952 homo sapiens (human). a- kinase anchor protein 12 (a-kinase SW:AKAC_HUMA anchor protein 250 kda) (akap 250) E.AEPAKELVK.L 1 2.183 0.123 A N (myasthenia gravis autoantigen gravin). 10/2001 Q01432 homo sapiens (human). amp SW:AMD3_HUMA deaminase 3 (ec 3.5.4.6) (amp IPI:IPI00007720.1 F.LGQNYYKEGPE.G 2 2.460 0.104 O N deaminase isoform e) (erythrocyte amp (95%) deaminase). 10/2001 P16157 homo sapiens (human). ankyrin SW:ANK1_HUMA IPI:IPI00007619.1 1 (erythrocyte ankyrin) (ankyrin r) V.KFLLQHQADVNAK.T 2 2.487 0.170 P N (97%) (ankyrins 2.1 and 2.2). 10/2001 Q01484 homo sapiens (human). ankyrin SW:ANK2_HUMA IPI:IPI00220735.1 2 (brain ankyrin) (ankyrin b) (ankyrin, F.SWTELARELDFTEEQIHQIRIENPNSLQ.D 3 3.936 0.081 A N (94%) nonerythroid). 10/2001 K.DCPSQDSSITTQ.T 1 1.992 0.100 P20594 homo sapiens (human). atrial natriuretic peptide receptor b precursor SW:ANPB_HUMA IPI:IPI00024685.1 (anp-b) (anprb) (gc-b) (guanylate L.LSGNPLPTTGMQKADVYSFGIILQ.E 2 2.503 0.154 G N (97%) cyclase) (ec 4.6.1.2) (npr-b) (atrial natriuretic peptide b-type receptor). 1 SW:ANR3_HUMA P57078 homo sapiens (human). P.PEPRSEVVPARLKRA.S 2 2.468 0.170 G N serine/threonine-protein kinase ankrd3
Supplementary Table 2 74 (ec 2.7.1.-) (ankyrin repeat domain protein 3) (pkc-delta-interacting protein kinase). 10/2001 P08133 homo sapiens (human). annexin SW:ANX6_HUMA vi (lipocortin vi) (p68) (p70) (protein iii) IPI:IPI00002459.1 D.ALSSDTSGHFRRILISL.A 2 2.534 0.111 O N (chromobindin 20) (67 kda calelectrin) (97%) (calphobindin-ii) (cpb-ii). 10/2001 P05412 homo sapiens (human). SW:AP1_HUMAN transcription factor ap-1 (proto-oncogene A.PAVASVAGGSGSGGFSASLHSEPPVYA.N 2 2.415 0.170 A c-jun) (p39) (g0s7). 10/2001 O96018 homo sapiens (human). amyloid beta a4 precursor protein-binding family SW:APB3_HUMAN a member 3 (neuron- specific x11l2 A.EDAQLIAQA.I 1 2.100 0.098 O protein) (neuronal munc18-1-interacting protein 3) (mint-3) (adapter protei P25054 homo sapiens (human). SW:APC_HUMAN adenomatous polyposis coli protein (apc Q.TGLSKNASSIPRSESASK.G 2 2.289 0.172 O protein). 10/2001 P35414 homo sapiens (human). IPI:IPI00180692.1 SW:APJ_HUMAN probable g protein-coupled receptor apj. Q.SECEYTDWK.S 2 2.365 0.131 O (92%) 10/2001 Q9bqe5 homo sapiens (human). SW:APL2_HUMAN apolipoprotein l2 (apolipoprotein l-ii) L.AYESKHLLEGAK.S 2 2.219 0.110 A (apol-ii). 10/2001 P08519 homo sapiens (human). SW:APOA_HUMA IPI:IPI00164229.1 apolipoprotein(a) precursor (ec 3.4.21.-) R.GTYSTTVTGR.T 2 2.383 0.365 O N (98%) (apo(a)) (lp(a)). 10/2001 Q13796 homo sapiens (human). apical- SW:APXL_HUMAN Q.RPAQKQALHGIPRDK.P 2 2.300 0.104 G like protein (apxl protein). 10/2001 O14520 homo sapiens (human). SW:AQP7_HUMA S.TYVMMVFGLGSVAHMVLNKKYGSYLGVN IPI:IPI00022359.1 aquaporin 7 (aquaporin-7 like) 2 2.422 0.165 A N LGF.G (92%) (aquaporin adipose) (aqpap). 10/2001 Q9h0f7 homo sapiens (human). adp- IPI:IPI00021685.1 SW:ARL6_HUMAN L.RDAVTSVKVSQLLC.L 2 2.416 0.147 O ribosylation factor-like protein 6. 10/2001 (94%) SW:ARR2_HUMA P32121 homo sapiens (human). beta- Y.ADICLFSTAQ.Y 2 2.468 0.125 P N arrestin 2. 10/2001 P18440 homo sapiens (human). arylamine n-acetyltransferase 1 (ec SW:ARY1_HUMA 2.3.1.5) (arylamide acetylase 1) V.FTSKSFCSLQTPDGVHCLVG.F 2 2.544 0.170 O N (arylamine n-acetyltransferase, monomorphic) (mnat) (n- acetyltransferase type 1) (nat-1). Q04656 homo sapiens (human). copper- transporting atpase 1 (ec 3.6.3.4) IPI:IPI00215614.1 SW:AT7A_HUMAN R.VAMVGDGINDSPALAMANVG.I 1 2.097 0.098 A (copper pump 1) (menkes disease- (96%) associated protein). 10/2001 Q93084 homo sapiens (human). sarcoplasmic/endoplasmic reticulum IPI:IPI00218440.1 SW:ATA3_HUMAN calcium atpase 3 (ec 3.6.3.8) (calcium L.SVLVTIEMCNALNSV.S 2 2.594 0.170 G (97%) pump 3) (serca3) (sr ca(2+)-atpase 3). 10/2001 P20020 homo sapiens (human). plasma membrane calcium-transporting atpase 1 (ec 3.6.3.8) (pmca1) (plasma membrane IPI:IPI00216526.1 SW:ATB1_HUMAN T.DALRKIQESYGDVYGICTK.L 2 2.272 0.162 O calcium pump isoform 1) (plasma (92%) membrane calcium atpase isoform 1). 10/2001 P98194 homo sapiens (human). calcium- transporting atpase type 2c, member 1 IPI:IPI00220473.1 SW:ATC1_HUMAN L.LLASAVISVLMHQFDDAVSITVAI.L 2 2.769 0.083 A (ec 3.6.3.8) (atpase 2c1) (atp-dependent (94%) ca2+ pump pmr1) (hussy-28). 10/2001 P18846 homo sapiens (human). cyclic- amp-dependent transcription factor atf-1 SW:ATF1_HUMAN R.PSYRKILKDLSSEDTR.G 2 2.672 0.109 P (activating transcription factor 1) (treb36 protein). 10/2001 P20648 homo sapiens (human). potassium-transporting atpase alpha SW:ATHA_HUMA IPI:IPI00218919.1 chain (ec 3.6.3.10) (proton pump) I.AGSDAAKNAADMILLDDNFASI.V 2 2.458 0.211 P N (94%) (gastric h+/k+ atpase alpha subunit). 10/2001 Q13315 homo sapiens (human). serine- protein kinase atm (ec 2.7.1.37) (ataxia Q.PITRLRTYEHEAMWGKALVTYDLETAIPSS IPI:IPI00045000.1 SW:ATM_HUMAN 3 3.807 0.118 A telangiectasia mutated) (a-t, mutated). TRQAGII.Q (99%) 10/2001 O75964 homo sapiens (human). atp SW:ATPN_HUMA IPI:IPI00027448.2 synthase g chain, mitochondrial (ec P.TPAEIPKAIQSLKK.I 2 2.411 0.132 A N (97%) 3.6.1.34) (atpase subunit g). 12/1998 Supplementary Table 2 75 Q9uhi8 homo sapiens (human). adam-ts 1 precursor (ec 3.4.24.-) (a disintegrin IPI:IPI00005908.1 SW:ATS1_HUMAN and metalloproteinase with L.QGVGQPTGTGSIRKKRFVS.S 2 2.411 0.218 O (92%) thrombospondin motifs 1) (adamts-1) (adam-ts1) (meth-1). 10/2001 P54253 homo sapiens (human). ataxin-1 SW:ATX1_HUMAN (spinocerebellar ataxia type 1 protein). K.LSVGDVCISLTLKNLKNGSV.K 2 2.414 0.204 O 10/2001 Q9nq11 homo sapiens (human). IPI:IPI00178530.1 SW:ATY1_HUMAN probable cation-transporting atpase 1 (ec A.LVLGRVRPPGALLSVPVLSSLL.L 2 2.475 0.169 P (95%) 3.6.1.-). 10/2001 Q9y2t1 homo sapiens (human). axin 2 SW:AXN2_HUMA (axis inhibition protein 2) (conductin) A.QTEIQSVMEE.N 1 2.022 0.140 A N (axin-like protein) (axil). 10/2001 Q9y2c3 h beta-1,3-galactosyltransferase 5 (ec 2.4.1.-) (beta-1,3-galtase 5) (beta3gal-t5) (b3gal-t5) (udp- SW:B3G5_HUMAN L.TELLLKKNRTTRFFTGFLK.L 2 2.306 0.115 A galactose:beta-n-acetylglucosamine beta- 1,3-galactosyltransferase 5) (udp- gal:bet O60909 h beta-1,4-galactosyltransferase 2 (ec 2.4.1.-) (beta-1,4-galtase 2) (beta4gal-t2) (b4gal-t2) (udp- SW:B4G2_HUMAN P.NATASSSGLPEVPSALP.G 2 3.307 0.113 G galactose:beta-n-acetylglucosamine beta- 1,4-galactosyltransferase 2) (udp- gal:bet P56817 homo sapiens beta-secretase precursor (ec 3.4.23.-) (beta-site app SW:BACE_HUMA cleaving enzyme) (beta-site amyloid IPI:IPI00177966.1 R.ETDEEPEEPGR.R 1 2.133 0.082 G N precursor protein cleaving enzyme) (99%) (aspartyl protease 2) (asp 2) (asp2) (membr O60242 homo sapiens (human). brain- IPI:IPI00028448.1 SW:BAI3_HUMAN specific angiogenesis inhibitor 3 E.KGTNPEGLSYSTLPGNVISKVII.Q 2 2.522 0.112 G (95%) precursor. 10/2001 SW:BASO_HUMA Q01954 homo sapiens (human). zinc IPI:IPI00010359.1 A.GGLFSALSNRGMAFPCL.E 2 2.428 0.129 A N finger protein basonuclin. 10/2001 (95%) P56945 homo sapiens (human). crk- SW:BCA1_HUMA associated substrate (p130cas) (breast Y.DVPPVRGLLPSQYGQ.E 1 2.124 0.117 A N cancer anti-estrogen resistance 1 protein). 10/2001 O15382 homo sapiens (human). SW:BCAM_HUMA branched-chain amino acid IPI:IPI00181105.1 G.NYKLGGNYGPTVLVQQEALK.R 2 2.279 0.110 P N aminotransferase, mitochondrial (96%) precursor (ec 2.6.1.42) (bcat(m)). 5/2000 Q14457 homo sapiens (human). beclin 1 SW:BCN1_HUMA (coiled-coil myosin-like bcl2-interacting V.LLLHALANKM.G 1 2.083 0.140 G N protein) (protein gt197). 10/2001 Q16548 homo sapiens (human). bcl-2- related protein a1 (bfl-1 protein) SW:BFL1_HUMAN V.KKFEPKSGWMTFLEVTGKICEMLS.L 2 2.406 0.142 A (hemopoietic-specific early response protein) (grs protein). 10/2001 Q9y6d5 homo sapiens (human). brefeldin a-inhibited guanine nucleotide- IPI:IPI00002186.1 SW:BIG2_HUMAN E.IKAEIEKQRLGTAAPPK.A 2 2.243 0.128 G exchange protein 2 (brefeldin a-inhibited (96%) gep 2). 10/2001 V.TTIFQHHF.P 1 2.134 0.090 P55107 homo sapiens (human). bone morphogenetic protein 3b precursor SW:BM3B_HUMA IPI:IPI00023315.1 (bmp-3b) (growth/differentiation factor L.LLRDVAGSHRAPAWSALPAA.A 2 2.409 0.167 A N (92%) 10) (gdf-10) (bone inducing protein) (bip). 10/2001 O00327 homo sapiens (human). bmal1 SW:BMAL_HUMA protein (brain and muscle arnt-like 1) IPI:IPI00217735.1 Y.VSRHAIDGKFVFVDQRATAILAYLP.Q 2 2.486 0.148 O N (member of pas protein 3) (mop3) (bhlh- (99%) pas protein jap3). 10/2001 Q13873 homo sapiens (human). bone SW:BMR2_HUMA morphogenetic protein receptor type ii IPI:IPI00027376.1 H.SKSSTAVYLAEGGTATTMVSKDI.G 2 2.756 0.086 A N precursor (ec 2.7.1.37) (bmp type ii (92%) receptor) (bmpr-ii). 10/2001 Q03001 homo sapiens (human). bullous pemphigoid antigen 1 (230 kda bullous IPI:IPI00217991.1 SW:BPA1_HUMAN pemphigoid antigen) (bpa) Q.TYSVEDAVLKGV.V 2 2.430 0.239 G (95%) (hemidesmosomal plaque protein). 10/2001 SW:BRC1_HUMA P38398 homo sapiens (human). breast A.RVGNIPSSTSALKVPQLK.V 2 2.403 0.163 A IPI:IPI00218982.1
Supplementary Table 2 76 N cancer type 1 susceptibility protein. (93%) 10/2001 P20264 homo sapiens (human). brain- SW:BRN1_HUMA specific homeobox/pou domain protein 1 P.PPQSLLYSQPGGFTVNGM.L 2 3.027 0.171 A N (brn-1 protein). 10/2001 Q14201 homo sapiens (human). btg3 SW:BTG3_HUMA IPI:IPI00029483.2 protein (tob5 protein) (abundant in N.KDENKDEISRK.V 1 2.204 0.134 A N (93%) neuroepithelium area protein). 10/2001 O95971 homo sapiens (human). natural SW:BY55_HUMAN killer cell receptor by55 precursor (cd160 A.ILLAIVDIQSGGCINITSSASQEGT.R 2 2.448 0.235 P antigen). 10/2001 O95177 homo sapiens (human). protein SW:C163_HUMAN V.GCPIACPVSCPVACPVGCPV.G 1 2.041 0.133 G c16orf3. 10/2001 P49238 homo sapiens (human). cx3c chemokine receptor 1 (c-x3-c ckr-1) SW:C3X1_HUMAN (cx3cr1) (fractalkine receptor) (gpr13) V.ETNFLGFLLPLLIMSYCYFRI.I 2 2.604 0.248 G (v28) (beta chemokine receptor-like 1) (cmk-brl-1) (cmkblr1). 10/2001 Q9nzb2 homo sapiens (human). protein SW:C910_HUMAN A.ASAEEVAKELKSK.S 2 2.567 0.106 G c9orf10. 10/2001 P05997 homo sapiens (human). collagen SW:CA25_HUMAN S.PGPQGSTGPQGNSGLPGDPGFK.G 2 2.378 0.157 G alpha 2(v) chain precursor. 10/2001 P12110 homo sapiens (human). collagen IPI:IPI00220613.1 SW:CA26_HUMAN R.KGAPGLAGK.N 1 1.849 0.172 A alpha 2(vi) chain precursor. 10/2001 (99%) SW:CA2B_HUMA P13942 homo sapiens (human). collagen E.KGEPGESGSPGIQGEPGVK.G 2 2.297 0.183 G N alpha 2(xi) chain precursor. 10/2001 Q01955 homo sapiens (human). collagen SW:CA34_HUMAN alpha 3(iv) chain precursor (goodpasture L.KGLPGPAGPPGPRGDLGSTGN.P 1 2.132 0.200 G antigen). 10/2001 P29400 homo sapiens (human). collagen SW:CA54_HUMAN R.GSPGIPGAPGPIGPPGS.P 1 1.959 0.150 A alpha 5(iv) chain precursor. 10/2001 P05937 homo sapiens (human). SW:CABV_HUMA calbindin (vitamin d-dependent calcium- E.IWLHFDADGSGYL.E 2 2.437 0.224 P N binding protein, avian-type) (calbindin d28) (d-28k). 10/2001 Q12864 homo sapiens (human). SW:CADH_HUMA cadherin-17 precursor (liver-intestine- IPI:IPI00029755.1 P.EPLVFGVKYNASSFAK.F 1 1.861 0.271 G N cadherin) (li-cadherin) (intestinal peptide- (96%) associated transporter hpt-1). 10/2001 Q92186 homo sapiens (human). alpha- SW:CAG9_HUMA 2,8-sialyltransferase (ec 2.4.99.-) IPI:IPI00020199.1 I.RKQILKFLDAEKDISVLK.G 2 2.272 0.191 O N (st8siaii) (sialyltransferase x) (stx). (96%) 10/2001 O75493 homo sapiens (human). carbonic anhydrase-related protein 2 SW:CAHB_HUMA IPI:IPI00025812.1 precursor (carp-2) (ca-rp ii) (ca-xi) D.PFLPPLRLSTGGEK.L 2 2.414 0.104 G N (96%) (carbonic anhydrase-related protein 11) (carp xi) (ca-rp xi). 10/2001 P27824 homo sapiens (human). calnexin SW:CALX_HUMA precursor (major histocompatibility I.LTVALPVFLVILFCCSGKKQTS.G 2 2.423 0.130 P N complex class i antigen-binding protein p88) (p90) (ip90). 10/2001 P17655 homo sapiens (human). calpain 2, large [catalytic] subunit precursor (ec SW:CAN2_HUMA IPI:IPI00015930.2 3.4.22.17) (calcium-activated neutral L.AAIASLTLNEEILARVVPLNQSFQENYA.G 2 2.501 0.176 O N (96%) proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain). 10/2001 O14958 homo sapiens (human). SW:CAQC_HUMA IPI:IPI00024758.2 calsequestrin, cardiac muscle isoform S.CRAEEGLNFPTYDGKDRVV.S 2 2.720 0.087 A N (96%) precursor. 10/2001 Q9uhj6 homo sapiens (human). SW:CARL_HUMA IPI:IPI00005914.1 carbohydrate kinase-like protein (ec V.FWKTGQGCEWTEGGI.T 1 2.271 0.115 G N (95%) 2.7.1.-). 10/2001 P55060 homo sapiens (human). chromosome segregation 1-like protein IPI:IPI00219762.1 SW:CAS_HUMAN A.LERLFTMRGPNNATLFTAAEI.A 2 2.465 0.249 G (cellular apoptosis susceptibility protein). (96%) 10/2001 O75718 homo sapiens (human). SW:CASP_HUMA IPI:IPI00220959.1 cartilage-associated protein precursor. M.EPGRRGAAALLALLCVACALRAGRAQ.Y 2 3.284 0.227 A N (99%) 10/2001 P41180 homo sapiens (human). SW:CASR_HUMA extracellular calcium-sensing receptor IPI:IPI00164260.1 Y.NVYLAVYSIAHALQDIYTCLPGRGLF.T 2 2.512 0.209 P N precursor (casr) (parathyroid cell (93%) calcium-sensing receptor). 10/2001 SW:CATE_HUMA P14091 homo sapiens (human). IPI:IPI00025062.1 F.SIQYGTGSLSGIIGADQVSVE.G 2 2.420 0.234 P N cathepsin e precursor (ec 3.4.23.34). (97%)
Supplementary Table 2 77 10/2001 Q9ubx1 homo sapiens (human). SW:CATF_HUMA IPI:IPI00002816.1 cathepsin f precursor (ec 3.4.22.41) A.PPEWDWRSKGAVTKVKDQGMCGS.C 2 2.431 0.198 O N (96%) (catsf). 10/2001 Q03701 homo sapiens (human). ccaat- IPI:IPI00011977.1 SW:CBF_HUMAN box-binding transcription factor (ccaat- V.KKKDVESKMLSAL.L 2 2.578 0.111 G (94%) binding factor) (cbf). 10/2001 P22681 homo sapiens (human). signal SW:CBL_HUMAN transduction protein cbl (proto-oncogene L.PPPPPPDRPYSVGAESR.P 2 2.321 0.188 P c-cbl). 10/2001 SW:CBX6_HUMA O95503 homo sapiens (human). K.VIDKGAGGGGAGQGAGALAR.P 2 2.538 0.207 O N chromobox protein homolog 6. 10/2001 Q00975 homo sapiens (human). voltage- dependent n-type calcium channel alpha- SW:CCAB_HUMA IPI:IPI00029885.1 1b subunit (calcium channel, l type, L.GGRYGGPGGGERARGGGAGGA.G 1 2.339 0.130 P N (98%) alpha-1 polypeptide isoform 5) (brain calcium channel iii) (biii). 10/2001 Q15878 homo sapiens (human). voltage- dependent r-type calcium channel alpha- SW:CCAE_HUMA 1e subunit (calcium channel, l type, P.LKLVSGIPSLQIVLKSIMKAMV.P 2 2.980 0.182 G N alpha-1 polypeptide, isoform 6) (brain calcium channel ii) (bii). 10/2001 O60840 homo sapiens (human). voltage- SW:CCAF_HUMA IPI:IPI00184083.1 dependent l-type calcium channel alpha- F.LFIIIFSLLGMQLFGGKFNFDQ.T 2 2.738 0.111 P N (97%) 1f subunit. 10/2001 Q08289 homo sapiens (human). dihydropyridine-sensitive l-type, calcium SW:CCB2_HUMA channel beta-2 subunit (lambert-eaton I.PANHRSPKPSANSVTSPHSKEKRM.P 2 2.757 0.120 P N myasthenic syndrome antigen b) (mysb). 10/2001 O60359 homo sapiens (human). voltage- SW:CCG3_HUMA dependent calcium channel gamma-3 IPI:IPI00029074.1 W.LYSRGVCRTKSTSDNETSRKN.E 2 2.585 0.135 G N subunit (neuronal voltage- gated calcium (92%) channel gamma-3 subunit). 10/2001 P16671 homo sapiens (human). platelet IPI:IPI00029797.1 SW:CD36_HUMAN glycoprotein iv (gpiv) (gpiiib) (cd36 G.TEADNFTVLNLAVAAASHIYQ.N 2 3.034 0.185 G (96%) antigen) (pas iv) (pas-4 protein). 10/2001 P08575 homo sapiens (human). leukocyte common antigen precursor (ec IPI:IPI00155168.1 SW:CD45_HUMAN A.DSQTPSAGTDTQTFS.G 2 2.588 0.302 P 3.1.3.48) (l-ca) (cd45 antigen) (t200). (96%) 10/2001 P08962 homo sapiens (human). cd63 antigen (melanoma-associated antigen me491) (lysosome-associated SW:CD63_HUMAN L.IAVGVGAQLVLSQTIIQGAT.P 2 2.421 0.143 P membrane glycoprotein 3) (lamp-3) (ocular melanoma-associated antigen) (oma81h) (granulop Q07108 homo sapiens (human). early activation antigen cd69 (early t-cell IPI:IPI00014854.1 SW:CD69_HUMAN activation antigen p60) (gp32/28) (leu-23) V.FLKNTEVSSME.C 1 2.104 0.138 G (94%) (mlr-3) (ea1) (bl-ac/p26) (activation inducer molecule) (aim). 10/2001 P09564 homo sapiens (human). t-cell SW:CD7_HUMAN antigen cd7 precursor (gp40) (t-cell P.HCTTVPVGASVNITCSTSGGLR.G 2 2.207 0.188 A leukemia antigen) (tp41) (leu-9). 10/2001 P33681 homo sapiens (human). t lymphocyte activation antigen cd80 SW:CD80_HUMAN precursor (activation b7-1 antigen) (ctla-4 E.TELYAVSSK.L 2 2.269 0.164 O counter-receptor b7.1) (b7) (bb1). 10/2001 Q9un73 homo sapiens (human). SW:CDA6_HUMA IPI:IPI00219062.1 protocadherin alpha 6 precursor (pcdh- S.VEVADMNDNAPAFAQPEYTVFV.K 2 2.709 0.129 G N (95%) alpha6). 10/2001 Q9un75 homo sapiens (human). SW:CDAC_HUMA IPI:IPI00219236.1 protocadherin alpha 12 precursor (pcdh- I.TFGKKEETKK.K 2 2.316 0.120 P N (95%) alpha12). 10/2001 Q9y5e3 homo sapiens (human). SW:CDB6_HUMA IPI:IPI00001426.1 protocadherin beta 6 precursor (pcdh- Y.QYKVCLTGGSETNEFKF.L 1 2.132 0.217 A N (95%) beta6). 10/2001 Q00534 homo sapiens (human). cell SW:CDK6_HUMA division protein kinase 6 (ec 2.7.1.-) I.KLADFGLARIYSFQMALTSVVVTLWYRAPE 3 3.848 0.263 O N (serine/threonine-protein kinase plstire). VL.L 10/2001 P51861 homo sapiens (human). SW:CDR1_HUMA cerebellar-degeneration-related antigen 1 T.DFLEDPDFLEAIDLR.E 2 2.238 0.157 G N (cdr34). 10/2001
Supplementary Table 2 78 Q15517 homo sapiens (human). SW:CDSN_HUMA corneodesmosin precursor (s protein). S.YLVPGMTYSK.G 2 2.317 0.100 P N 10/2001 P13688 homo sapiens (human). carcinoembryonic antigen-related cell SW:CEA1_HUMA IPI:IPI00216037.1 adhesion molecule 1 precursor (biliary I.AVALACFLHFGKTGR.A 2 2.204 0.108 G N (98%) glycoprotein 1) (bgp-1) (antigen cd66) (cd66a antigen). 10/2001 P49450 homo sapiens (human). SW:CENA_HUMA centromere protein a (cenp-a) A.QALLALQEAAEAFLVHLFEDA.Y 2 2.796 0.091 A N (centromere autoantigen a). 10/2001 P11597 homo sapiens (human). SW:CETP_HUMA cholesteryl ester transfer protein IPI:IPI00006173.1 L.SDGDIGVDISL.T 2 2.566 0.107 A N precursor (lipid transfer protein i). (93%) 10/2001 O15519 h casp8 and fadd-like apoptosis regulator precursor (cellular flice-like IPI:IPI00216960.1 SW:CFLA_HUMAN inhibitory protein) (c-flip) (caspase-eight- Q.KYKQSVQGA.G 1 2.013 0.115 A (99%) related protein) (casper) (caspase-like apoptosis regulatory pro SW:CG65_HUMA Q9y375 homo sapiens (human). IPI:IPI00032560.2 F.LKMGKNNQSALLYGTLSSEAPQ.D 2 2.442 0.117 G N hypothetical protein cgi-65. 10/2001 (99%) SW:CGA1_HUMA P78396 homo sapiens (human). cyclin IPI:IPI00019284.1 F.EDVYEVDTGTLKSDLH.F 2 2.880 0.125 A N a1. 10/2001 (93%) SW:CHE1_HUMA O00409 homo sapiens (human). R.SVSPVQDLDDDTPPSPAHSDMPYDA.R 2 2.464 0.216 P N checkpoint suppressor 1. 10/2001 P51800 homo sapiens (human). chloride IPI:IPI00020879.1 SW:CICK_HUMAN A.EPPSRAPGHQ.Q 1 2.000 0.092 G channel protein clc-ka (clc-k1). 10/2001 (92%) Q9nr82 homo sapiens (human). voltage- IPI:IPI00219528.1 SW:CIQ5_HUMAN gated potassium channel protein kqt-like L.LGTRAATLGGGGGGLRESRR.G 2 2.233 0.121 O (93%) 5. 10/2001 Q9nse2 homo sapiens (human). cytokine-inducible sh2-containing protein SW:CISH_HUMAN R.LVINRLVADVDCLPLPR.R 2 2.350 0.107 A (suppressor of cytokine signaling) (socs) (cis1) (g18). 10/2001 P51684 homo sapiens (human). c-c chemokine receptor type 6 (c-c ckr-6) SW:CKR6_HUMA IPI:IPI00019984.1 (cc-ckr-6) (ccr-6) (larc receptor) (gpr-cy4) F.FIPLMFMIF.C 1 2.088 0.131 O N (96%) (gprcy4) (chemokine receptor-like 3) (ckr- l3) (dry6). 10/2001 P51685 homo sapiens (human). c-c chemokine receptor type 8 (c-c ckr-8) SW:CKR8_HUMA IPI:IPI00019985.1 (cc-ckr-8) (ccr-8) (gpr-cy6) (gprcy6) M.DYTLDLSVTTVTDYYY.P 2 2.541 0.144 P N (91%) (chemokine receptor-like 1) (ckr-l1) (ter1) (cmkbrl2) (cc- chemokine receptor c P51793 homo sapiens (human). chloride SW:CLC4_HUMAN V.YTAMWQLALALIFKIV.V 1 2.129 0.110 G channel protein 4 (clc-4). 7/1998 P51797 homo sapiens (human). chloride IPI:IPI00220727.1 SW:CLC6_HUMAN G.EFKCSDSDK.K 1 1.874 0.113 O channel protein 6 (clc-6). 10/2001 (93%) O14493 homo sapiens (human). claudin- SW:CLD4_HUMAN 4 (clostridium perfringens enterotoxin L.AGLMVIVPVSWTAHNII.Q 2 2.542 0.213 G receptor) (cpe- receptor) (cpe-r). 5/2000 O00501 homo sapiens (human). claudin- SW:CLD5_HUMAN 5 (transmembrane protein deleted in G.PAKARVALTGGVLYLFCGLLALVPL.C 2 2.570 0.114 O vcfs) (tmdvcf). 10/2001 O95471 homo sapiens (human). claudin- SW:CLD7_HUMAN K.ARIAMGGGIIFIVAGLAALV.A 2 2.480 0.243 G 7. 5/2000 P53675 homo sapiens (human). clathrin IPI:IPI00022881.1 SW:CLH2_HUMAN M.PYFIQVMREYLSKVDK.L 2 2.270 0.121 A heavy chain 2 (clh-22). 10/2001 (97%) O15247 homo sapiens (human). chloride SW:CLI2_HUMAN intracellular channel protein 2 (xap121). L.KTDFIKIEEFLE.Q 1 2.439 0.096 P 10/2001 O76031 homo sapiens (human). atp- SW:CLPX_HUMA dependent clp protease atp-binding D.KCELNVTEDALKAIARLALERKTGARGLRS 3 3.516 0.125 O N subunit clpx-like, mitochondrial IMEK.L precursor. 10/2001 Q9y233 homo sapiens (human). camp and camp-inhibited cgmp 3',5'-cyclic SW:CN10_HUMAN I.QSVLCLPIVTAIGDLIGILELYRH.W 2 2.673 0.229 O phosphodiesterase 10a (ec 3.1.4.17). 5/2000 Q13370 homo sapiens (human). cgmp- inhibited 3',5'-cyclic phosphodiesterase b SW:CN3B_HUMA (ec 3.1.4.17) (cyclic gmp inhibited R.SSCVSLGETAAS.Y 1 1.914 0.087 A N phosphodiesterase b) (cgi-pde b) (cgipde1) (cgip1). 10/2001 SW:CN5A_HUMA O76074 homo sapiens (human). cgmp- K.NGKKNKVIG.V 1 1.971 0.136 A, O IPI:IPI00218455.1
Supplementary Table 2 79 N specific 3',5'-cyclic phosphodiesterase (97%) (ec 3.1.4.17) (cgb-pde) (cgmp-binding cgmp-specific phosphodiesterase). 10/2001 O60658 homo sapiens (human). high- SW:CN8A_HUMA affinity camp-specific and ibmx- IPI:IPI00218162.1 L.IYLGLKMFARFGI.C 2 2.561 0.100 G N insensitive 3',5'-cyclic phosphodiesterase (99%) 8a (ec 3.1.4.17) (fragment). 10/2001 SW:CNE1_HUMA Q99829 homo sapiens (human). copine i. IPI:IPI00000976.1 F.QNAPREALAQTVLAE.V 2 2.583 0.173 P N 10/2001 (95%) Q9h4w6 homo sapiens (human). SW:COE3_HUMA transcription factor coe3 (early b-cell IPI:IPI00024242.1 V.FGTMLVWSELITPHAIRVQTPPR.H 2 2.260 0.198 G N factor 3) (ebf-3) (olf-1/ebf- like 2) (oe-2) (97%) (o/e-2). 10/2001 SW:COF1_HUMA P23528 homo sapiens (human). cofilin, V.KDRCTLAEKLGGSAVISLE.G 2 2.561 0.100 P N non-muscle isoform. 10/2001 SW:COF2_HUMA Q9y281 homo sapiens (human). cofilin, V.LFCLSDDKR.Q 2 2.219 0.106 G N muscle isoform (cofilin 2). 10/2001 P48444 homo sapiens (human). SW:COPD_HUMA IPI:IPI00216681.1 coatomer delta subunit (delta-coat P.APARPSGPSKALKLGAKGKEVDNFVDK.L 2 2.277 0.134 O N (94%) protein) (delta-cop) (archain). 10/2001 Q9y2z9 homo sapiens (human). putative SW:COQ6_HUMA K.VLEKLSETYSNRVSSISPGSATLLSSFGAW IPI:IPI00032633.2 ubiquinone biosynthesis monooxgenase 3 3.559 0.091 G N DHICN.M (95%) coq6 (ec 1.14.13.-) (cgi-10). 10/2001 Q9y5q5 homo sapiens (human). atrial natriuteric peptide-converting enzyme (ec IPI:IPI00001715.1 SW:CORI_HUMAN 3.4.21.-) (pro-anp- converting enzyme) L.YNPCLDSCGGSSLCDPNNSLNN.C 2 2.402 0.305 O (95%) (corin) (heart specific serine proteinase atc2). 10/2001 V.CFSKVLGPGVYSNVSYF.V 2 2.501 0.221 P04798 homo sapiens (human). cytochrome p450 1a1 (ec 1.14.14.1) IPI:IPI00218839.1 SW:CP11_HUMAN D.PASSTSCYLEEHVSKEAEV.L 2 2.686 0.102 O (cypia1) (p450-p1) (p450 form 6) (p450- (99%) c). 10/2001 Q9y6a2 homo sapiens (human). IPI:IPI00002133.1 SW:CP46_HUMAN cytochrome p450 46 (ec 1.14.-.-) A.KAAFGMETSMLLGAQ.K 2 2.698 0.081 G (96%) (cholesterol 24-hydroxylase). 10/2001 Q9unu6 homo sapiens (human). cytochrome p450 8b1 (ec 1.14.-.-) SW:CP8B_HUMA IPI:IPI00009440.1 (cypviiib1) (sterol 12-alpha- hydroxylase) I.LLMVTHFDLELVDPDTPLPH.V 2 2.685 0.095 P N (97%) (7 alpha-hydroxy-4-cholesten-3-one 12- alpha-hydroxylase). 10/2001 P05181 homo sapiens (human). SW:CPE1_HUMA IPI:IPI00007282.1 cytochrome p450 2e1 (ec 1.14.14.1) Y.KDEFSGRGDLPAFHAHR.D 2 2.302 0.132 P N (94%) (cypiie1) (p450-j). 5/2000 Q9ubf2 homo sapiens (human). SW:CPG2_HUMA IPI:IPI00002557.1 coatomer gamma-2 subunit (gamma-2 E.AFFAMTRLFQSNDQTLRR.M 2 2.388 0.116 G N (94%) coat protein) (gamma-2 cop). 10/2001 Q9p2i0 homo sapiens (human). cleavage SW:CPSB_HUMA and polyadenylation specificity factor, A.EFVGGVLVCNNQVAVR.R 2 2.244 0.122 P N 100 kda subunit (cpsf 100 kda subunit) (fragment). 10/2001 P31327 homo sapiens (human). carbamoyl-phosphate synthase SW:CPSM_HUMA IPI:IPI00011062.1 [ammonia], mitochondrial precursor (ec L.ITGLAAGAKTYKM.S 2 2.621 0.151 P N (98%) 6.3.4.16) (carbamoyl-phosphate synthetase i) (cpsase i). 10/2001 P16220 homo sapiens (human). camp- SW:CREB_HUMA response element binding protein (creb). A.IQLANNGTDGVQGLQTLTMTNA.A 2 2.666 0.151 A N 10/2001 P07316 homo sapiens (human). gamma SW:CRGB_HUMA crystallin b (gamma crystallin 1-2). L.SDSIRSCCLIPPHSGAYR.M 2 2.423 0.159 A N 11/1997 Q14008 homo sapiens (human). ch-tog SW:CTOG_HUMA IPI:IPI00028275.1 protein (colonic and hepatic tumor over- T.VRCEMPELVQHKLDDIFEP.V 2 3.213 0.168 O N (91%) expressed protein). 10/2001 Q92879 homo sapiens (human). cug triplet repeat rna-binding protein 1 (cug- SW:CUG1_HUMA IPI:IPI00180937.1 bp1) (rna-binding protein brunol-2) V.NPIASLGALQ.T 2 2.760 0.116 O N (93%) (deadenylation factor cug-bp) (50 kda nuclear polyadenylated rna-binding prot Q13616 homo sapiens (human). cullin IPI:IPI00014310.1 SW:CUL1_HUMAN L.KDGEDLMDESVLKFYTQQ.W 2 2.450 0.106 G homolog 1 (cul-1). 10/2001 (98%) P36383 homo sapiens (human). gap SW:CXA7_HUMA IPI:IPI00002946.1 junction alpha-7 protein (connexin 45) I.AYKQNKANTAQEQ.Q 2 2.605 0.094 A N (97%) (cx45). 10/2001
Supplementary Table 2 80 P51828 homo sapiens (human). SW:CYA7_HUMA adenylate cyclase, type vii (ec 4.6.1.1) M.AFLVLAVFAALSVLMYVECLLRRW.L 2 2.465 0.106 P N (atp pyrophosphate-lyase) (adenylyl cyclase). 10/2001 O60503 homo sapiens (human). SW:CYA9_HUMA adenylate cyclase, type ix (ec 4.6.1.1) D.EIANLVPSVQYVDKTSLGSD.S 2 3.378 0.180 P N (atp pyrophosphate-lyase) (adenylyl cyclase). 10/2001 O43739 homo sapiens (human). cytohesin 3 (arf nucleotide-binding site SW:CYH3_HUMA IPI:IPI00186302.1 opener 3) (arno3 protein) (general I.NEGGDLPEELLRNLYES.I 1 2.116 0.122 G N (99%) receptor of phosphoinositides 1) (grp1). 10/2001 SW:CYH4_HUMA Q9uia0 homo sapiens (human). G.EGLNKTAI.G 2 2.462 0.133 O N cytohesin 4. 10/2001 P05092 homo sapiens (human), cercopithecus aethiops (green monkey) SW:CYPH_HUMA (grivet), macaca mulatta (rhesus IPI:IPI00027388.3 P.LGRVSFELFADKV.P 2 2.667 0.084 O N macaque), and papio anubis peptidyl- (96%) prolyl cis-trans isomerase a (ec 5.2.1.8) (ppiase) ( O15228 homo sapiens (human). dihydroxyacetone phosphate SW:DAPT_HUMA acyltransferase (ec 2.3.1.42) (dhap-at) IPI:IPI00005677.1 R.SAKTLTPKFGLLNIVMEPFFKREVFDT.Y 3 3.600 0.097 O N (dap-at) (glycerone-phosphate o- (98%) acyltransferase) (acyl- coa:dihydroxyacetonephosphateacyltra P52895 homo sapiens (human). probable trans-1,2-dihydrobenzene-1,2- diol dehydrogenase (ec 1.3.1.20) IPI:IPI00005668.2 SW:DBDI_HUMAN A.GLAKSIGVSNFNHRLLEMILNEP.G 2 2.814 0.114 O (chlordecone reductase homolog hakrd) (99%) (dihydrodiol dehydrogenase/bile acid- binding prote P21918 homo sapiens (human). d(1b) SW:DBDR_HUMA dopamine receptor (d(5) dopamine IPI:IPI00011227.1 I.WVAFDIMCSTASILNLCVISVDR.Y 2 2.209 0.182 P N receptor) (d1beta dopamine receptor). (95%) 10/2001 P10911 homo sapiens (human). proto- IPI:IPI00023597.1 SW:DBL_HUMAN oncogene dbl precursor [contains: mcf2]. I.FENQQAGFRNLADK.H 2 2.523 0.137 A (95%) 10/2001 Q10586 homo sapiens (human). d-site- SW:DBP_HUMAN binding protein (albumin d box-binding A.ATTPGPGLETAGPADAP.A 1 2.322 0.080 G protein) (taxreb302). 10/2001 P43146 homo sapiens (human). tumor V.VKSDEGFYQCVAENEAGNAQTSAQLIVPK IPI:IPI00016422.1 SW:DCC_HUMAN suppressor protein dcc precursor 3 3.861 0.137 A PAI.P (95%) (colorectal cancer suppressor). 10/2001 P43353 homo sapiens (human). SW:DHA7_HUMA IPI:IPI00181005.1 aldehyde dehydrogenase 7 (ec 1.2.1.5). Y.IFFTGSPRVG.K 2 2.418 0.104 P N (96%) 10/2001 P51659 homo sapiens (human). estradiol SW:DHB4_HUMA 17 beta-dehydrogenase 4 (ec 1.1.1.62) IPI:IPI00019912.1 M.TSSASGIYGNFGQA.N 1 2.139 0.097 A N (17-beta-hsd 4) (17-beta-hydroxysteroid (92%) dehydrogenase 4). 10/2001 P49448 homo sapiens (human). SW:DHE4_HUMA glutamate dehydrogenase 2, IPI:IPI00027146.1 F.GKHGGTIPIVPTAEFQDSISGAS.E 2 2.848 0.088 A N mitochondrial precursor (ec 1.4.1.3) (94%) (gdh). 10/2001 O60879 homo sapiens (human). diaphanous protein homolog 2 IPI:IPI00184417.1 SW:DIA2_HUMAN L.ERDIKKFPQAENQHDKFVEK.M 2 2.232 0.111 P (diaphanous-related formin 2) (drf2). (98%) 10/2001 P25686 homo sapiens (human). dnaj homolog subfamily b member 2 (heat SW:DJB2_HUMAN A.QPDLIQ.I 1 2.077 1.000 A shock 40 kda protein 3) (dnaj protein homolog 1) (hsj-1). 10/2001 O14490 homo sapiens (human). disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) SW:DLP1_HUMAN V.NMDQAMVKSE.S 2 2.491 0.168 O (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding prot Q9y6k1 homo sapiens (human). dna SW:DM3A_HUMA (cytosine-5)-methyltransferase 3a (ec IPI:IPI00220006.1 K.AKVIAGMNAVEE.N 1 1.931 0.104 G N 2.1.1.37) (dna methyltransferase hsaiiia) (94%) (dna mtase hsaiiia) (m.hsaiiia). 10/2001 SW:DM3B_HUMA Q9ubc3 homo sapiens (human). dna Y.LVLKELGIKVGKYVASE.V 2 2.756 0.260 G N (cytosine-5)-methyltransferase 3b (ec
Supplementary Table 2 81 2.1.1.37) (dna methyltransferase hsaiiib) (dna mtase hsaiiib) (m.hsaiiib). 10/2001 P11532 homo sapiens (human). IPI:IPI00029070.1 SW:DMD_HUMAN A.PISPEEQDKLENKLKQ.T 2 2.584 0.120 O dystrophin. 10/2001 (97%) P56282 homo sapiens (human). dna SW:DPE2_HUMA IPI:IPI00008829.1 polymerase epsilon subunit b (ec 2.7.7.7) V.FLSDVWLDQVEVLEK.L 2 2.310 0.100 O N (97%) (dna polymerase ii subunit b). 5/2000 P09884 homo sapiens (human). dna SW:DPOA_HUMA polymerase alpha catalytic subunit (ec H.TWKDAKFILQIMCELNVLPLAL.Q 2 2.600 0.115 A N 2.7.7.7). 10/2001 O75417 homo sapiens (human). dna SW:DPOQ_HUMA IPI:IPI00066511.1 polymerase theta (ec 2.7.7.7) (dna L.DINKEKPGASQNEGKTSDKKVVQTFSQK.T 2 2.368 0.151 P N (94%) polymerase eta). 5/2000 Q9uhl4 homo sapiens (human). dipeptidyl-peptidase ii precursor (ec SW:DPP2_HUMA IPI:IPI00005921.2 3.4.14.2) (dpp ii) (dipeptidyl L.TVEQALADFAE.L 2 2.485 0.128 P N (95%) aminopeptidase ii) (quiescent cell proline dipeptidase). 10/2001 Q9ny33 homo sapiens (human). SW:DPP3_HUMA dipeptidyl-peptidase iii (ec 3.4.14.4) (dpp IPI:IPI00163204.1 S.VLGSEPSLDSEVTSKLKSYE.F 2 3.180 0.189 G N iii) (dipeptidyl aminopeptidase iii) (99%) (dipeptidyl arylamidase iii). 10/2001 P42658 homo sapiens (human). dipeptidyl peptidase iv like protein SW:DPP6_HUMA IPI:IPI00019658.2 (dipeptidyl aminopeptidase- related W.KGIAIALLVI.L 1 2.208 0.080 P N (96%) protein) (dipeptidylpeptidase vi) (dppx). 10/2001 P40879 homo sapiens (human). dra IPI:IPI00031036.1 SW:DRA_HUMAN protein (down-regulated in adenoma). D.CFGIAMVAFAVAFSVASVYSLK.Y 2 2.448 0.125 O (91%) 10/2001 SW:DREB_HUMA Q16643 homo sapiens (human). drebrin T.PIPTRSPSDSSTASTPVAEQIERA.L 2 2.471 0.118 G N e. 10/2001 Q99856 homo sapiens (human). dead SW:DRI1_HUMAN ringer like-1 protein (b-cell regulator of K.GGGGGGGSSSNAGGRGGNTGTS.G 2 2.552 0.176 O igh transcription) (bright). 10/2001 P49184 homo sapiens (human). muscle- SW:DRNL_HUMA specific dnase i-like precursor (ec A.VEKELNALYDVFLEVSQHW.Q 2 2.662 0.134 G N 3.1.21.-) (dnase x) (xib). 10/2001 Q08554 homo sapiens (human). SW:DSC1_HUMA desmocollin 1a/1b precursor IPI:IPI00007425.1 A.ETLVGKVNLEECLKSASLIRS.S 2 2.400 0.192 A N (desmosomal glycoprotein 2/3) (97%) (dg2/dg3). 10/2001 Q02413 homo sapiens (human). SW:DSG1_HUMA desmoglein 1 precursor (desmosomal V.RVLDINDNPPVFSMATFAGQI.E 2 2.450 0.298 A N glycoprotein 1) (dg1) (dgi) (pemphigus foliaceus antigen). 10/2001 P50443 homo sapiens (human). sulfate SW:DTD_HUMAN transporter (diastrophic dysplasia H.RILIERQEKSDTNFKEF.V 2 2.656 0.114 P protein). 10/2001 Q13202 homo sapiens (human). dual SW:DUS8_HUMA specificity protein phosphatase 8 (ec G.MSSDDAYRFVK.D 1 1.813 0.085 O N 3.1.3.48) (ec 3.1.3.16) (dual specificity protein phosphatase hvh-5). 10/2001 Q9nyc9 homo sapiens (human). ciliary SW:DYH9_HUMA dynein heavy chain (axonemal dynein IPI:IPI00005823.1 D.SKSETVLDSIDKSV.I 2 2.690 0.098 A N heavy chain) (dynein heavy chain 9). (96%) 10/2001 Q9ui46 homo sapiens (human). dynein intermediate chain 1, axonemal IPI:IPI00006030.1 SW:DYI3_HUMAN R.KLTNQFNFSERASQTYNNPVRDRE.C 3 3.530 0.121 P (axonemal dynein intermediate chain 1). (94%) 10/2001 Q9y463 homo sapiens (human). dual- SW:DYRB_HUMA specificity tyrosine-phosphorylation T.LGPHLGLRGVPQSTA.A 2 2.511 0.105 O N regulated kinase 1b (ec 2.7.1.-) (mirk protein kinase). 10/2001 Q9nr50 homo sapiens (human). SW:E2BG_HUMA translation initiation factor eif-2b gamma IPI:IPI00006504.1 W.NACRGDRWEDL.S 1 2.168 0.108 G N subunit (eif-2b gdp-gtp exchange factor). (97%) 10/2001 O00341 homo sapiens (human). IPI:IPI00178797.1 SW:EAA5_HUMAN excitatory amino acid transporter 5 Y.LWTTFMAVIVGIFMVSIIHPGSAA.Q 2 2.849 0.106 G (98%) (retinal glutamate transporter). 10/2001 O00472 homo sapiens (human). rna SW:ELL2_HUMAN polymerase ii elongation factor ell2. V.HNFNFYLSNVGKDNPQGSFDCIQ.Q 2 2.819 0.118 P 7/1999 SW:ENOB_HUMA P13929 homo sapiens (human). beta F.LSGVNIQIVGDDLTVTNPKRIAQAVEKKAC 2 2.484 0.158 A IPI:IPI00218474.1
Supplementary Table 2 82 N enolase (ec 4.2.1.11) (2-phospho-d- NC.L (97%) glycerate hydro-lyase) (skeletal muscle enolase) (mse). 10/2001 O75355 homo sapiens (human). ectonucleoside triphosphate SW:ENP3_HUMA diphosphohydrolase 3 (ec 3.6.1.5) IPI:IPI00182170.1 Y.GWITANYLMGNF.L 2 2.591 0.112 O N (ntpdase3) (ecto-atp (95%) diphosphohydrolase) (atpdase) (ecto- apyrase) (cd39 antigen-like 3) (hb6). 10 P54756 homo sapiens (human). ephrin type-a receptor 5 precursor (ec 2.7.1.112) (tyrosine-protein kinase IPI:IPI00008290.1 SW:EPA5_HUMAN L.EVSGSCVNHSVTDEPPK.M 2 2.297 0.319 A receptor ehk-1) (eph homology kinase-1) (95%) (receptor protein- tyrosine kinase hek7). 10 P29323 homo sapiens (human). ephrin type-b receptor 2 precursor (ec IPI:IPI00219421.1 SW:EPB2_HUMAN 2.7.1.112) (tyrosine-protein kinase W.MENPWVKVDTIAA.D 2 2.590 0.153 P (98%) receptor eph-3) (drt) (receptor protein- tyrosine kinase hek5) (erk). 10/2001 P54760 homo sapiens (human). ephrin type-b receptor 4 precursor (ec IPI:IPI00008310.2 SW:EPB4_HUMAN D.REVPPAVSDIRVTRSSPSSLSLAWAV.P 2 2.630 0.089 P 2.7.1.112) (tyrosine-protein kinase (94%) receptor htk). 10/2001 P04626 homo sapiens (human). receptor protein-tyrosine kinase erbb-2 precursor SW:ERB2_HUMA IPI:IPI00038700.1 (ec 2.7.1.112) (p185erbb2) (neu proto- G.VTVWELMTFGAK.P 2 2.242 0.121 G N (98%) oncogene) (c-erbb-2) (tyrosine kinase- type cell surface receptor her2) Q03468 homo sapiens (human). excision SW:ERC6_HUMA repair protein ercc-6 (cockayne D.LYELFTLTSPDASQSTETSA.I 2 2.408 0.177 A N syndrome protein csb). 10/2001 SW:ESR2_HUMA Q92731 homo sapiens (human). IPI:IPI00218157.1 L.TLLEAEPPHVLISRPSAPFTE.A 2 2.614 0.102 O N estrogen receptor beta (er-beta). 10/2001 (96%) Q15910 homo sapiens (human). SW:EZH2_HUMAN enhancer of zeste homolog 2 (enx-1). P.CDHPRQPCDSSCPCVIAQNFCEK.F 2 2.402 0.169 A 7/1999 P15311 homo sapiens (human). ezrin IPI:IPI00007154.1 SW:EZRI_HUMAN A.MLEYLKIAQDLEMYG.I 1 2.038 0.152 O (p81) (cytovillin) (villin 2). 10/2001 (97%) P05160 homo sapiens (human). coagulation factor xiii b chain precursor SW:F13B_HUMAN (ec 2.3.2.13) (protein- glutamine gamma- K.IQTHSTTYR.H 2 2.456 0.230 P glutamyltransferase b chain) (transglutaminase b chain). 10/2001 P09467 homo sapiens (human). fructose-1,6-bisphosphatase (ec IPI:IPI00073772.1 SW:F16P_HUMAN R.APVILGSPDDVLEFLKVYEK.H 2 2.414 0.157 O, P 3.1.3.11) (d-fructose-1,6-bisphosphate 1- (95%) phosphohydrolase) (fbpase). 10/2001 P00451 homo sapiens (human). coagulation factor viii precursor R.PGKVPFLRVATESSAKTPSKLLDPLAWDN IPI:IPI00017603.1 SW:FA8_HUMAN 3 3.597 0.132 O, P (procoagulant component) HYGTQI.P (97%) (antihemophilic factor) (ahf). 10/2001 Q01469 homo sapiens (human). fatty SW:FABE_HUMA acid-binding protein, epidermal (e-fabp) IPI:IPI00176868.1 V.QQLEGRWRLVDSKGFDEY.M 2 2.475 0.172 G N (psoriasis-associated fatty acid-binding (97%) protein homolog) (pa-fabp). 10/2001 Q14289 homo sapiens (human). focal adhesion kinase 2 (ec 2.7.1.112) (fadk 2) IPI:IPI00029702.1 SW:FAK2_HUMAN (proline-rich tyrosine kinase 2) (cell I.ITSILLSGR.I 1 1.804 0.136 G (94%) adhesion kinase beta) (cak beta). 10/2001 P49327 homo sapiens (human). fatty acid synthase (ec 2.3.1.85) [includes: ec IPI:IPI00026781.1 SW:FAS_HUMAN 2.3.1.38; ec 2.3.1.39; ec 2.3.1.41; ec P.VESPAPRGTPLISPLIK.W 2 2.311 0.206 P (97%) 1.1.1.100; ec 4.2.1.61; ec 1.3.1.10; ec 3.1.2.14]. 10/2001 Q14296 homo sapiens (human). fas- IPI:IPI00018084.1 SW:FAST_HUMAN activated serine/threonine kinase (ec P.PKPPPPLQPLLRGGQGLEAALSCPRFLR.Y 2 2.337 0.118 P (94%) 2.7.1.-) (fast kinase). 10/2001 O95967 homo sapiens (human). egf- containing fibulin-like extracellular matrix IPI:IPI00185647.1 SW:FBL4_HUMAN A.HQCSEAQTCVNFHGGYRC.V 2 2.615 0.158 G protein 2 precursor (fibulin-4) (fibl-4) (98%) (uph1 protein). 10/2001 P35556 homo sapiens (human). fibrillin 2 IPI:IPI00019439.1 SW:FBN2_HUMAN M.PNLCTNGQCINTMGSF.R 2 2.526 0.237 P precursor. 10/2001 (95%) Q9y3i1 homo sapiens (human). f-box IPI:IPI00218249.1 SW:FBX7_HUMAN L.CTWGYSSNTRFTITLNY.K 2 2.825 0.113 P only protein 7. 10/2001 (94%) Supplementary Table 2 83 P98174 homo sapiens (human). putative SW:FGD1_HUMA rho/rac guanine nucleotide exchange Y.ELLGGEEDIVSPTKELIK.E 2 2.454 0.150 G N factor (rho/rac gef) (faciogenital dysplasia protein). 10/2001 P11362 homo sapiens (human). basic fibroblast growth factor receptor 1 SW:FGR1_HUMA IPI:IPI00012036.1 precursor (ec 2.7.1.112) (fgfr-1) (bfgf-r) S.TDNTK.E 1 2.010 0.111 A N (95%) (fms-like tyrosine kinase-2) (c-fgr). 10/2001 P22455 homo sapiens (human). SW:FGR4_HUMA IPI:IPI00010661.1 fibroblast growth factor receptor 4 L.ESGSSGKSSSSLVRGVR.L 1 2.067 0.106 G N (99%) precursor (ec 2.7.1.112) (fgfr-4). 10/2001 P36980 homo sapiens (human). SW:FHR2_HUMA complement factor h-related protein 2 IPI:IPI00006154.1 W.TNQQKLYSRTGDIVEFVCKS.G 2 2.548 0.127 G N precursor (fhr-2) (h factor-like protein 2) (94%) (h factor-like 3) (ddesk59). 10/2001 Q14318 homo sapiens (human). 38 kda IPI:IPI00220401.1 SW:FKB8_HUMAN fk-506 binding protein homolog (fkbpr38) Y.RAALRSCSLVLEHQPDNIKA.L 2 2.449 0.119 P (95%) (fk506-binding protein 8). 10/2001 P49771 homo sapiens (human). sl IPI:IPI00216372.1 SW:FL3L_HUMAN cytokine precursor (fms-related tyrosine T.APTAPQPPLLLLLLLPVGLLLL.A 2 2.741 0.111 P (91%) kinase 3 ligand) (flt3 ligand). 10/2001 Q13045 homo sapiens (human). S.KLKKLYLNSNKLDFDGLPSGIGKLTNLEEF. IPI:IPI00031023.1 SW:FLIH_HUMAN 3 3.838 0.106 A flightless-i protein homolog. 10/2001 M (91%) Q14254 homo sapiens (human). flotillin-2 K.VDYLSSLGKTQTAVVQRDADIGVAEAERD IPI:IPI00029625.1 SW:FLT2_HUMAN (epidermal surface antigen) (esa). 3 3.660 0.186 P AGI.R (94%) 10/2001 Q99518 homo sapiens (human). dimethylaniline monooxygenase [n-oxide SW:FMO2_HUMA forming] 2 (ec 1.14.13.8) (pulmonary K.VAVIGAGVSGLISLK.C 1 1.893 0.161 A N flavin-containing monooxygenase 2) (fmo 2) (dimethylaniline oxidase 2) (fmo 1b1). 5 P51816 homo sapiens (human). fragile x mental retardation 2 protein (protein fmr- SW:FMR2_HUMA IPI:IPI00178794.1 2) (fmr2p) (ox19 protein) (fragile x e S.PTLKPSIEFENSFG.N 2 3.210 0.181 A, O N (95%) mental retardation syndrome protein). 10/2001 P53539 homo sapiens (human). fosb SW:FOSB_HUMA M.SGYSSGGASGSGGPSTSGTTSGPGPAR. protein (g0/g1 switch regulatory protein 2 2.285 0.119 A N P 3). 10/2001 P14324 homo sapiens (human). farnesyl pyrophosphate synthetase (fpp SW:FPPS_HUMA synthetase) (fps) (farnesyl diphosphate IPI:IPI00030108.1 W.CVELLQAFFLVADDIMDSSL.T 2 2.780 0.164 O N synthetase) [includes: (91%) dimethylallyltransferase (ec 2.5.1.1); geranyltranstransf P42345 homo sapiens (human). fkbp- SW:FRAP_HUMA IPI:IPI00031410.1 rapamycin associated protein (frap) F.ELVSSSDANERKGGIL.A 2 2.695 0.110 G N (93%) (rapamycin target protein). 10/2001 K.PEALNK.K 1 1.867 0.085 P02794 homo sapiens (human). ferritin IPI:IPI00176715.1 SW:FRIH_HUMAN Y.LSMSYYFDRDDVALKNFAK.Y 2 2.237 0.183 A heavy chain (ferritin h subunit). 10/2001 (95%) P35637 homo sapiens (human). rna- binding protein fus (oncogene fus) SW:FUS_HUMAN (oncogene tls) (translocated in A.YPTQPGQGYSQQ.S 1 2.380 0.082 G liposarcoma protein) (pomp75) (75 kda dna-pairing protein). 10/2001 Q06136 homo sapiens (human). follicular SW:FVT1_HUMAN variant translocation protein 1 precursor F.AIRGLAEALQMEVKPYN.V 2 2.490 0.136 P (fvt-1). 10/2001 Q99853 homo sapiens (human). SW:FXB1_HUMAN forkhead box protein b1 (transcription K.VLKSDHLAPSKPADAQY.L 2 2.483 0.138 A factor fkh-5). 5/2000 Q99958 homo sapiens (human). forkhead box protein c2 (forkhead-related SW:FXC2_HUMAN protein fkhl14) (mesenchyme fork head G.AGRAGLVVPPLALPYAAA.P 2 2.437 0.232 A protein 1) (mfh-1 protein) (transcription factor fkh-14). 10/2001 Q16676 homo sapiens (human). forkhead box protein d1 (forkhead- I.LLAPPAGGSPAPPGPAPAAGAGAGGGGG IPI:IPI00030209.1 SW:FXD1_HUMAN 2 2.605 0.116 P related protein fkhl8) (forkhead- related GGGAGGGG.S (96%) transcription factor 4) (freac-4). 5/2000 Q12946 homo sapiens (human). SW:FXF1_HUMAN forkhead box protein f1 (forkhead-related A.SPLLPTGAGGVMEPHAVYSGS.A 2 2.403 0.133 A protein fkhl5) (forkhead- related
Supplementary Table 2 84 transcription factor 1) (freac-1) (forkhead- related activator- 1). 10/2001 O14556 homo sapiens (human). putative SW:G3PT_HUMA glyceraldehyde 3-phosphate N.IIPASTGAAKAVTKVIPELK.G 2 2.322 0.182 A N dehydrogenase, testis-specific (ec 1.2.1.12) (gapdh-2). 5/2000 Q9un88 homo sapiens (human). gamma- SW:GAAT_HUMA aminobutyric-acid receptor theta subunit V.YWPTVLTTITSWISF.W 1 2.035 0.108 A N precursor (gaba(a) receptor). 10/2001 P28472 homo sapiens (human). gamma- SW:GAB3_HUMA aminobutyric-acid receptor beta-3 IPI:IPI00217235.1 V.FPFTFSLFNLVYWLYYVN.- 2 2.443 0.150 P N subunit precursor (gaba(a) receptor). (97%) 10/2001 P54803 homo sapiens (human). galactocerebrosidase precursor (ec SW:GALC_HUMA 3.2.1.46) (galcerase) IPI:IPI00008790.1 A.LLAPGGAYVLDDS.D 1 2.207 0.091 P N (galactosylceramidase) (97%) (galactosylceramide beta-galactosidase) (galactocerebroside beta-galactosidase) Q9h2c0 homo sapiens (human). IPI:IPI00022758.1 SW:GAN_HUMAN N.IPLSQPQQGEAMLANFKPRGYSE.C 2 3.027 0.103 G gigaxonin. 10/2001 (96%) Q14392 homo sapiens (human). garp SW:GARP_HUMA IPI:IPI00030280.1 protein precursor (garpin) (glycoprotein a L.AMATALSAGGLGPLPRVTSL.D 2 2.876 0.118 G N (96%) repetitions predominant). 10/2001 P23769 homo sapiens (human). SW:GAT2_HUMA endothelial transcription factor gata-2. G.HLPPFSHSGHILPTPTPIHPSSSLSF.G 2 2.461 0.152 G N 10/2001 Q92908 homo sapiens (human). SW:GAT6_HUMA transcription factor gata-6 (gata binding A.HVSARFPYSPSPPMANGAAREP.G 2 2.655 0.119 O N factor-6). 10/2001 Q14344 homo sapiens (human). guanine IPI:IPI00170614.1 SW:GB13_HUMAN nucleotide-binding protein, alpha-13 Q.QDILLARRPTKGI.H 1 2.044 0.115 G (99%) subunit (g alpha 13). 10/2001 O14775 homo sapiens (human). guanine SW:GBB5_HUMA IPI:IPI00007787.1 nucleotide-binding protein beta subunit 5 E.LHQVAERVEALGQFVMKTRR.T 2 2.259 0.107 P N (97%) (transducin beta chain 5). 10/2001 P04899 homo sapiens (human). guanine nucleotide-binding protein g(i), alpha-2 IPI:IPI00180475.1 SW:GBI2_HUMAN Y.DEAASYIQSK.F 1 1.845 0.088 A subunit (adenylate cyclase-inhibiting g (96%) alpha protein). 10/2001 P25388 homo sapiens (human), mus musculus (mouse), rattus norvegicus SW:GBLP_HUMA (rat), sus scrofa (pig) guanine nucleotide- N.ALCFSPNRYWLCAATGPSIKIWDLEGK.I 2 2.354 0.194 O N binding protein beta subunit-like protein 12.3 (p205) (receptor of activated P50148 homo sapiens (human). guanine IPI:IPI00176624.1 SW:GBQ_HUMAN nucleotide-binding protein g(q), alpha R.EYQLSDSTK.Y 1 1.991 0.139 P (95%) subunit. 10/2001 P52951 homo sapiens (human). SW:GBX2_HUMA homeobox protein gbx-2 (gastrulation R.VKAGNANSKTGEPSRNPK.I 1 1.927 0.159 O N and brain-specific homeobox protein 2). 10/2001 P35573 homo sapiens (human). glycogen debranching enzyme (glycogen debrancher) [includes: 4-alpha- IPI:IPI00219065.1 SW:GDE_HUMAN L.PILSPALMDVPY.R 1 2.142 0.123 O glucanotransferase (ec 2.4.1.25) (oligo- (99%) 1,4-1,4-glucantransferase); amylo-1,6- glucosidase P52566 homo sapiens (human). rho gdp- IPI:IPI00003817.1 SW:GDIS_HUMAN dissociation inhibitor 2 (rho gdi 2) (rho- E.KLNYK.D 1 1.813 0.121 P (95%) gdi beta) (ly-gdi). 10/2001 P52306 homo sapiens (human). rap1 SW:GDS1_HUMA gtpase-gdp dissociation stimulator 1 M.QNEALVALALIAALELGTAEKDLESAKLVQI IPI:IPI00221083.1 3 3.642 0.261 P N (smg p21 stimulatory gdp/gtp exchange LHR.L (96%) protein) (smg gds protein). 10/1996 P57678 homo sapiens (human). SW:GEM4_HUMA IPI:IPI00027717.1 component of gems 4 (gemin4) (p97). E.IVSANAETFSPDVWI.K 2 2.614 0.113 A N (98%) 10/2001 Q14161 homo sapiens (human). arf gtpase-activating protein git2 (g protein- IPI:IPI00216996.1 SW:GIT2_HUMAN A.GQILQAELLAVYGAD.P 2 2.843 0.085 P coupled receptor kinase- interactor 2). (98%) 10/2001 P08151 homo sapiens (human). zinc SW:GLI1_HUMAN finger protein gli1 (glioma-associated A.HVTKRHRGDGPLPRAPSISTVEPK.R 2 2.396 0.114 P oncogene) (oncogene gli). 10/2001 P10071 homo sapiens (human). zinc SW:GLI3_HUMAN C.NPPAMATSAEKR.S 1 2.079 0.085 G finger protein gli3. 10/2001 Supplementary Table 2 85 P39086 homo sapiens (human). glutamate receptor, ionotropic kainate 1 IPI:IPI00064770.1 SW:GLK1_HUMAN precursor (glutamate receptor 5) (glur-5) V.NVEELAFKFAVTSINR.N 3 3.631 0.218 P (97%) (excitatory amino acid receptor 3) (eaa3). 10/2001 O94925 homo sapiens (human). glutaminase, kidney isoform, SW:GLSK_HUMA IPI:IPI00181991.1 mitochondrial precursor (ec 3.5.1.2) (gls) G.GRPAAGPAAAARLHPWWGGGGWPA.E 2 2.658 0.087 G N (99%) (l-glutamine amidohydrolase) (k- glutaminase). 10/2001 P26572 homo sapiens (human). alpha- 1,3-mannosyl-glycoprotein beta-1,2-n- SW:GNT1_HUMA IPI:IPI00179044.1 acetylglucosaminyltransferase (ec G.HEETAQAIASYGSAVTHIRQPDLSSI.A 2 2.589 0.144 A, G N (98%) 2.4.1.101) (n-glycosyl- oligosaccharide- glycoprotein n-acetylglucosaminyltransfer O15354 homo sapiens (human). probable g protein-coupled receptor SW:GP37_HUMAN M.DLLNIISQFLL.F 1 2.077 0.133 G gpr37 precursor (endothelin b receptor- like protein-1) (etbr-lp-1). 10/2001 P46095 homo sapiens (human). SW:GPR6_HUMA probable g protein-coupled receptor L.GVHLLLAATWTVSLG.L 2 2.458 0.129 G N gpr6. 10/2001 Q99678 homo sapiens (human). SW:GPRK_HUMA probable g protein-coupled receptor R.AVCAFVWLAAGAVTLSVLG.V 2 2.572 0.086 O N gpr20. 10/2001 Q13098 homo sapiens (human). g SW:GPS1_HUMA IPI:IPI00011595.2 protein pathway suppressor 1 (gps1 F.PELLSPSNVAIYGGLC.A 1 2.089 0.184 G N (94%) protein) (mfh protein). 10/2001 P40197 homo sapiens (human). platelet IPI:IPI00027410.1 SW:GPV_HUMAN glycoprotein v precursor (gpv) (cd42d). V.QLDHNQLETLPGDVFGALPRLT.E 2 2.451 0.125 A (92%) 10/2001 P12544 homo sapiens (human). granzyme a precursor (ec 3.4.21.78) SW:GRAA_HUMA (cytotoxic t-lymphocyte proteinase 1) IPI:IPI00024657.1 V.VVSLLLIPEDV.C 1 2.004 0.083 A N (hanukkah factor) (h factor) (hf) (95%) (granzyme 1) (ctl tryptase) (fragmentin 1). 10/2001 Q13322 homo sapiens (human). growth SW:GRBA_HUMA factor receptor-bound protein 10 (grb10 IPI:IPI00218910.1 S.QAAAKQDVKVFSEDGTSK.V 1 1.840 0.115 G N adaptor protein) (insulin receptor binding (97%) protein grb-ir). 10/2001 Q14449 homo sapiens (human). growth SW:GRBE_HUMA IPI:IPI00030917.1 factor receptor-bound protein 14 (grb14 E.VLSNWGIEEENKLYFR.K 2 2.250 0.115 P N (95%) adapter protein). 7/1999 P34947 homo sapiens (human). g SW:GRK5_HUMA IPI:IPI00219995.1 protein-coupled receptor kinase grk5 (ec Q.NNSKSSPSSKTSFNH.H 2 3.279 0.338 G N (93%) 2.7.1.-). 10/2001 P09341 homo sapiens (human). growth regulated protein precursor (melanoma SW:GRO_HUMAN growth stimulatory activity) (mgsa) T.LQGIHPKNIQSVNVKSPGPHCA.Q 2 2.612 0.083 G (neutrophil-activating protein 3) (nap-3). 10/2001 SW:GTR2_HUMA P11168 homo sapiens (human). glucose IPI:IPI00003905.1 F.YYSTSIFQTAGISKPVYATI.G 3 3.831 0.111 O N transporter type 2, liver. 10/2001 (96%) P16401 homo sapiens (human). histone SW:H15_HUMAN A.KPKAAKPKAAKPKAAKAKKAAAKKK.- 2 2.353 0.112 A h1.5 (histone h1a). 10/2001 Q92522 homo sapiens (human). histone SW:H1X_HUMAN M.AKKVTKAGGSAALSPSKKRKNSKK.K 2 2.429 0.165 O h1x. 10/2001 P20036 homo sapiens (human). hla class ii histocompatibility antigen, dp SW:HA2Q_HUMA alpha chain precursor (hla-sb alpha Q.MPETTETVL.C 2 2.497 0.108 O N chain) (mhc class ii dp3-alpha) (dp(w3)) (dp(w4)). 10/2001 P50219 homo sapiens (human). P.SPPRLLAAHCALLPKPGFLGAGGGGGGT SW:HB9_HUMAN 3 3.925 0.276 G homeobox protein hb9. 10/1996 GGGHGGPHHHAHPGAAAAAAAAAA.A S.GSCSPASSEPPAAPADRLRAESPSPPRLL 3 3.520 0.099 AAHCALLPK.P Q99075 homo sapiens (human). heparin- SW:HBGF_HUMA binding egf-like growth factor precursor L.LMFRYHRRGGYDVENEE.K 2 2.883 0.088 O N (hb-egf) (hbegf) (diphteria toxin receptor) (dt-r). 10/2001 Q9nyh9 homo sapiens (human). IPI:IPI00020128.1 SW:HC66_HUMAN hepatocellular carcinoma-associated D.TEAVFKKALLAVIGADSVTLKNKY.L 2 2.423 0.217 G (95%) antigen 66. 10/2001 Q99714 homo sapiens (human). 3- SW:HCD2_HUMA IPI:IPI00017726.1 hydroxyacyl-coa dehydrogenase type ii K.GLVAVITGGASGLGL.A 1 1.909 0.096 P N (95%) (ec 1.1.1.35) (type ii hadh) (endoplasmic Supplementary Table 2 86 reticulum-associated amyloid beta- peptide binding protein) (short-chain type SW:HDA6_HUMA Q9ubn7 homo sapiens (human). histone IPI:IPI00184734.1 L.VSAGFDAARGDPLGGCQVSPE.G 2 2.869 0.111 A N deacetylase 6 (hd6). 10/2001 (96%) Q13268 homo sapiens (human). hep27 IPI:IPI00218235.1 SW:HE27_HUMAN A.AYNPVVALGVYNVSKTALLGLTRTL.A 2 2.575 0.251 P protein (protein d). 10/2001 (93%) P36551 homo sapiens (human). coproporphyrinogen iii oxidase, SW:HEM6_HUMA H.RCSSFMAPPVTDLGELRRRPGDMKTKME IPI:IPI00093057.1 mitochondrial precursor (ec 1.3.3.3) 3 3.755 0.158 A N LL.I (96%) (coproporphyrinogenase) (coprogen oxidase) (cox). 10/2001 P51610 homo sapiens (human). host cell SW:HFC1_HUMA I.ATGHGQQGVTQVVLKGAPGQPGTILRTVP factor c1 (hcf) (vp16 accessory protein) 2 2.453 0.243 O N MGGVRL.V (hfc1) (vcaf) (cff). 10/2001 P05114 homo sapiens (human). SW:HG14_HUMA nonhistone chromosomal protein hmg- R.GAKGKQAEVANQETK.E 2 2.349 0.146 P N 14. 10/2001 P25021 homo sapiens (human). SW:HH2R_HUMA IPI:IPI00012312.1 histamine h2 receptor (h2r) (gastric G.LLVLPFSAIYQLSCKWSFGK.V 2 2.273 0.206 P N (95%) receptor i). 10/2001 Q9h2x6 homo sapiens (human). IPI:IPI00215949.1 SW:HIK2_HUMAN homeodomain-interacting protein kinase M.QQPALLTGHVTLPAAQPLNVGVAHVMR.Q 2 2.319 0.193 O (94%) 2 (ec 2.7.1.-). 10/2001 N.VTSTSGHSSGSSSGAITYR.Q 2 2.666 0.260 Q01804 homo sapiens (human). putative SW:HIN1_HUMAN V.FKTDVSKIVMELDTLEVADEDNSEI.S 3 3.965 0.139 P hiv-1 induced protein hin-1. 10/2001 P54198 homo sapiens (human). hira R.TSNSGRQAARLFSVPHVVQQETTLAYLEN IPI:IPI00218434.1 SW:HIRA_HUMAN protein (tup1 like enhancer of split protein 2 2.591 0.152 A .Q (93%) 1). 10/2001 Q14774 homo sapiens (human). S.ESLDMAPSDTERTEGSERSLHQTTVIKAP SW:HLX1_HUMAN homeobox protein hlx1 (homeobox 3 3.758 0.212 G VTGALITA.S protein hb24). 11/1997 Q9ugu5 homo sapiens (human). high- SW:HM21_HUMA IPI:IPI00175020.1 mobility group protein 2-like 1 (hmgbcg L.LLGHELQSFLKTARKKHKS.S 2 2.449 0.130 G N (98%) protein). 10/2001 O75330 homo sapiens (human). hyaluronan mediated motility receptor SW:HMMR_HUMA (intracellular hyaluronic acid binding T.LEKQLIELTR.T 2 2.282 0.112 O N protein) (receptor for hyaluronan- mediated motility) (cd168 antigen). 10/2001 P28360 homo sapiens (human). SW:HMX1_HUMA homeobox protein msx-1 (hox-7). A.AGASLYGASGPFQR.A 1 1.859 0.204 A N 10/2001 P00492 homo sapiens (human). SW:HPRT_HUMA hypoxanthine-guanine V.IGGDDLSTLTGKNVLI.V 1 2.141 0.111 O N phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). 10/2001 Q92902 homo sapiens (human). IPI:IPI00024233.1 SW:HPS_HUMAN hermansky-pudlak syndrome protein. D.FLLVKSRRNIT.M 2 3.002 0.154 O (95%) 10/2001 P83110 homo sapiens (human). SW:HRA3_HUMA A.SNPDFPEVSSGIYVQEVAPNSPSQRGGIQ probable serine protease htra3 precursor 3 3.649 0.154 A N DGDIIVK.V (ec 3.4.21.-). 10/2001 Q03164 homo sapiens (human). zinc SW:HRX_HUMAN finger protein hrx (all-1) (trithorax-like P.WEEREKILSSMGNDDKSSI.A 2 2.438 0.144 A protein). 10/2001 P07900 homo sapiens (human). heat SW:HS9A_HUMA IPI:IPI00047217.5 shock protein hsp 90-alpha (hsp 86). Q.DRTLTIVDTGIGMTKADLINNLGTI.A 2 2.553 0.143 O, P N (92%) 10/2001 Q03933 homo sapiens (human). heat IPI:IPI00012878.1 SW:HSF2_HUMAN shock factor protein 2 (hsf 2) (heat shock E.PTQSKLVRLEPLTEAEASEA.T 2 2.466 0.171 O (94%) transcription factor 2) (hstf 2). 10/2001 P01744 homo sapiens (human). ig heavy SW:HV1C_HUMA chain v-i region nd precursor (fragments). Q.LVQSGAEVR.K 1 1.843 0.083 G N 10/2001 SW:HV2E_HUMA P01818 homo sapiens (human). ig heavy L.LYWDDDKR.F 2 2.499 0.251 G N chain v-ii region he. 7/1999 P31269 homo sapiens (human). SW:HXA9_HUMA IPI:IPI00031722.1 homeobox protein hox-a9 (hox-1g). L.AEHPDFSPCSFQSKATVFGA.S 2 2.402 0.149 O N (95%) 7/1999 P31271 homo sapiens (human). SW:HXAD_HUMA homeobox protein hox-a13 (hox-1j). A.AAAAAAAAGAGGGGFPHPAAAA.A 2 2.531 0.106 O N 12/1998 SW:HXB2_HUMA P14652 homo sapiens (human). IPI:IPI00031463.1 A.PPAPEFPWMKEKKSAK.K 1 1.878 0.083 G N homeobox protein hox-b2 (hox-2h) (hox- (98%)
Supplementary Table 2 87 2.8) (k8). 10/1996 SW:HXCA_HUMA Q9nyd6 homo sapiens (human). IPI:IPI00020947.2 E.KERAKAADSSPDTSDNEAKEEIKA.E 2 2.601 0.172 A N homeobox protein hox-c10. 10/2001 (95%) P28356 homo sapiens (human). SW:HXD9_HUMA IPI:IPI00031722.1 homeobox protein hox-d9 (hox-4c) (hox- E.VFAARFGPPGPGAQGRPAGVA.D 1 2.136 0.089 P N (92%) 5.2). 7/1993 P52789 homo sapiens (human). SW:HXK2_HUMA IPI:IPI00102864.1 hexokinase, type ii (ec 2.7.1.1) (hk ii) G.IFETK.F 1 1.823 1.000 P N (99%) (muscle form hexokinase). 10/2001 P07099 homo sapiens (human). epoxide SW:HYEP_HUMA hydrolase 1 (ec 3.3.2.3) (microsomal IPI:IPI00009896.1 E.FYIQGGDWGSLICTNMAQL.V 2 2.502 0.118 O N epoxide hydrolase) (epoxide hydratase). (96%) 10/2001 P29460 homo sapiens (human). interleukin-12 beta chain precursor (il- IPI:IPI00021798.1 SW:I12B_HUMAN 12b) (cytotoxic lymphocyte maturation E.LKKDVYVVELDWYPDAPGE.M 2 3.620 0.259 G, O (96%) factor 40 kda subunit) (clmf p40) (nk cell stimulatory factor chain 2) (nksf2). 1 P10997 homo sapiens (human). islet amyloid polypeptide precursor (diabetes- SW:IAPP_HUMAN V.GSNTYGKRNAVEVLKREPLNYL.P 2 2.413 0.185 P associated peptide) (dap) (amylin) (insulinoma amyloid peptide). 10/2001 P22692 homo sapiens (human). insulin- like growth factor binding protein 4 R.NGNFHPKQCHPALDGQRGKCWCVDRKT IPI:IPI00027282.1 SW:IBP4_HUMAN 2 2.251 0.106 A precursor (igfbp-4) (ibp-4) (igf-binding GVK.L (94%) protein 4). 10/2001 Q05084 homo sapiens (human). 69 kda IPI:IPI00007470.1 SW:ICA6_HUMAN islet cell autoantigen (ica69) (islet cell A.LLWMKDVSQELDPDLYKQ.M 2 2.457 0.123 G (99%) autoantigen 1). 10/2001 P20810 homo sapiens (human). calpain SW:ICAL_HUMAN inhibitor (calpastatin) (sperm bs-17 A.VEALADSLGKKEADPEDGKPVMDK.V 2 2.251 0.118 A component). 10/2001 P49662 homo sapiens (human). caspase-4 precursor (ec 3.4.22.-) (casp- IPI:IPI00187194.1 SW:ICE4_HUMAN A.DFDITGMKELLEGLDYSVDV.E 2 2.495 0.136 A 4) (ich-2 protease) (tx protease) (ice(rel)- (95%) ii). 10/2001 P55212 homo sapiens (human). IPI:IPI00023876.2 SW:ICE6_HUMAN caspase-6 precursor (ec 3.4.22.-) F.SDLGFEVKCFNDLKAEELLLKIHE.V 3 3.950 0.217 O (99%) (apoptotic protease mch-2). 10/2001 P41134 homo sapiens (human). dna- IPI:IPI00012718.2 SW:ID1_HUMAN E.ISALTAEAACVPADDRI.L 1 2.218 0.101 O binding protein inhibitor id-1 (id). 10/2001 (92%) P51553 homo sapiens (human). isocitrate dehydrogenase [nad] subunit R.HKDIDILIVRENTEGEYSSLEHESVAGVVE IPI:IPI00220150.1 SW:IDHG_HUMAN gamma, mitochondrial precursor (ec 3 3.565 0.165 A SLKII.T (93%) 1.1.1.41) (isocitric dehydrogenase) (nad+-specific icdh). 10/2001 P22304 homo sapiens (human). IPI:IPI00026104.1 SW:IDS_HUMAN iduronate 2-sulfatase precursor (ec V.GRLLSALDDLQLANSTIIAFTSDHG.W 2 2.429 0.130 A (97%) 3.1.6.13). 10/2001 Q16666 homo sapiens (human). gamma- interferon-inducible protein ifi-16 IPI:IPI00217475.1 SW:IF16_HUMAN (interferon-inducible myeloid N.IVLLKGLEVINDYHFRMVK.S 2 2.576 0.162 A (94%) differentiation transcriptional activator) (ifi 16). 10/2001 Q99613 homo sapiens (human). IPI:IPI00219966.1 SW:IF38_HUMAN eukaryotic translation initiation factor 3 I.RTIRNAMKIRDVTKCLE.E 2 2.690 0.110 A (95%) subunit 8 (eif3 p110). 10/2001 P.PVQILYNRTMVQLGICAFR.Q 2 2.248 0.118 Q04637 homo sapiens (human). eukaryotic translation initiation factor 4 SW:IF4G_HUMAN I.KEKKTSSRIRFMLQ.D 1 2.038 0.082 G gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). 10/2001 P55010 homo sapiens (human). IPI:IPI00179676.1 SW:IF5_HUMAN eukaryotic translation initiation factor 5 V.SSSETPPPPPPPNEINPPP.H 1 2.137 0.139 A (98%) (eif-5). 10/2001 P10159 homo sapiens (human), and mus musculus (mouse). initiation factor 5a IPI:IPI00218084.1 SW:IF5A_HUMAN F.ETGDAGASATF.P 1 2.010 0.246 G (eif-5a) (eif-4d) (rev-binding factor). (97%) 10/2001 Q12894 homo sapiens (human). SW:IFR2_HUMAN interferon-related developmental T.QISHILDRQLPRLPQL.L 2 2.515 0.224 O regulator 2 (skmc15 protein). 5/2000 O00221 homo sapiens (human). nf- kappab inhibitor epsilon (nf-kappa-bie) (i- SW:IKBE_HUMAN Q.KNQPLMELLLRNGAD.I 2 3.332 0.185 O kappa-b-epsilon) (ikappabepsilon) (ikb- epsilon) (ikbe). 10/2001
Supplementary Table 2 88 Q16552 homo sapiens (human). interleukin-17 precursor (il-17) (cytotoxic SW:IL17_HUMAN S.VPIQQEILVLRREPPHC.P 2 3.551 0.158 A t lymphocyte-associated antigen 8) (ctla- 8). 10/2001 Q01167 homo sapiens (human). interleukin enhancer-binding factor 1 IPI:IPI00220427.1 SW:ILF1_HUMAN G.APPLQLPRVCTFRFPSTNIK.I 3 3.669 0.084 O (cellular transcription factor ilf-1). (94%) 10/2001 Q14974 homo sapiens (human). importin beta-1 subunit (karyopherin beta-1 IPI:IPI00001639.2 SW:IMB1_HUMAN L.EFTKANFDKE.S 1 2.550 0.081 A, O subunit) (nuclear factor p97) (importin (97%) 90). 10/2001 P01570 homo sapiens (human). interferon alpha-14 precursor (interferon IPI:IPI00003086.3 SW:INAD_HUMAN K.YFQRITLY.L 1 1.883 0.129 P alpha-h) (leif h) (interferon lambda-2-h). (92%) 10/2001 P37290 homo sapiens (human). SW:IND1_HUMAN L.SLLMALVLVSYGPGGSLGCDLSQNHV.L 2 2.409 0.195 A interferon delta-1 precursor. 10/2001 P05000 homo sapiens (human). SW:INO1_HUMAN interferon omega-1 precursor (interferon L.AALVMTSYSPVGSLGCDLPQNHGL.L 2 2.437 0.148 P alpha-ii-1). 10/2001 P48551 homo sapiens (human). interferon-alpha/beta receptor beta chain IPI:IPI00220691.1 SW:INR2_HUMAN precursor (ifn-alpha-rec) (type i interferon A.VIKSPLKCTLLPPGQESES.A 2 2.862 0.107 O (98%) receptor) (ifn-r) (interferon alpha/beta receptor- 2). 10/2001 Q9c010 homo sapiens (human). camp- SW:IPKB_HUMAN dependent protein kinase inhibitor, beta V.ESGVANFASSARAG.R 2 2.402 0.101 G form (pki-beta). 10/2001 Q14653 homo sapiens (human). SW:IRF3_HUMAN interferon regulatory factor 3 (irf-3). V.FDLGPFIVDLITFTEGSGRS.P 2 2.690 0.125 A 10/2001 P35568 homo sapiens (human). insulin SW:IRS1_HUMAN A.LGAGGGGGSCSGSSGLGEAGEDL.S 2 2.547 0.102 P receptor substrate-1 (irs-1). 10/2001 Q9y4h2 homo sapiens (human). insulin SW:IRS2_HUMAN A.LKELFEFR.P 1 2.077 0.087 O receptor substrate-2 (irs-2). 10/2001 P26006 homo sapiens (human). integrin alpha-3 precursor (galactoprotein b3) IPI:IPI00029512.1 SW:ITA3_HUMAN A.QALENHTEVQFQK.E 2 2.229 0.212 G (gapb3) (vla-3 alpha chain) (cd49c). (92%) 10/2001 P13612 homo sapiens (human). integrin IPI:IPI00009803.1 SW:ITA4_HUMAN alpha-4 precursor (integrin alpha-iv) (vla- F.VYGSNDENEPET.C 2 2.665 0.232 A, O (98%) 4) (cd49d). 10/2001 P53708 homo sapiens (human). integrin IPI:IPI00023410.1 SW:ITA8_HUMAN L.VGAPKANTSQPDIVEGG.A 1 2.009 0.159 A alpha-8. 10/2001 (96%) P08514 homo sapiens (human). integrin alpha-iib precursor (platelet membrane IPI:IPI00218629.1 SW:ITAB_HUMAN W.ALNLDPVQLTF.Y 2 2.583 0.100 P glycoprotein iib) (gpalpha iib) (gpiib) (94%) (cd41). 10/2001 Q9ukx5 homo sapiens (human). integrin IPI:IPI00215613.1 SW:ITAH_HUMAN G.NKWLVVGAPLETNGYQK.T 2 2.254 0.189 P alpha-11 precursor. 10/2001 (98%) P05556 homo sapiens (human). integrin beta-1 precursor (fibronectin receptor IPI:IPI00217562.1 SW:ITB1_HUMAN F.NCDRSNGLICGGNGVCKCRVCE.C 2 2.505 0.117 G beta subunit) (cd29) (integrin vla-4 beta (96%) subunit). 10/2001 P16144 homo sapiens (human). integrin IPI:IPI00027422.1 SW:ITB4_HUMAN beta-4 precursor (gp150) (cd104). G.NLKGRDVVRWKVTNNMQRPGF.A 2 2.611 0.121 G (93%) 10/2001 P26010 homo sapiens (human). integrin IPI:IPI00219113.1 SW:ITB7_HUMAN S.GNLDSPEGGFDAILQAALC.Q 2 3.026 0.135 P beta-7 precursor. 10/2001 (92%) P23458 homo sapiens (human). tyrosine- IPI:IPI00011633.1 SW:JAK1_HUMAN protein kinase jak1 (ec 2.7.1.112) (janus F.LPSGSLKEYLPKNKNKINLKQQLKYAVQ.I 3 3.933 0.167 P (96%) kinase 1) (jak-1). 10/2001 O76011 homo sapiens (human). keratin, SW:K1M4_HUMA IPI:IPI00216855.1 type i cuticular ha4 (hair keratin, type i A.PTVDLNQVLNETRSQYEALVE.I 2 2.522 0.209 A N (95%) ha4). 10/2001 Q92764 homo sapiens (human). keratin, SW:K1M5_HUMA type i cuticular ha5 (hair keratin, type i V.RHVEQENASLESRIRE.W 1 2.027 0.095 A N ha5). 10/2001 Q01546 homo sapiens (human). keratin, IPI:IPI00008359.1 SW:K22O_HUMAN type ii cytoskeletal 2 oral (cytokeratin 2p) G.FAGGYGGGFGGSYGGGFGGGR.G 1 1.931 0.082 A (96%) (k2p) (ck 2p). 10/2001 P17858 homo sapiens (human). 6- phosphofructokinase, liver type (ec IPI:IPI00179103.1 SW:K6PL_HUMAN S.FENNWNIYK.L 1 1.840 0.084 O 2.7.1.11) (phosphofructokinase 1) (99%) (phosphohexokinase) (phosphofructo-1-
Supplementary Table 2 89 kinase isozyme b) (pfk-b). 10/2001 Q00653 homo sapiens (human). nuclear factor nf-kappa-b p100 subunit (h2tf1) IPI:IPI00219797.1 SW:KBF2_HUMAN (oncogene lyt-10) (lyt10) [contains: G.GSGGAAGGYGGAGGGGSL.G 1 2.045 0.101 G (99%) nuclear factor nf-kappa-b p52 subunit]. 10/2001 O75600 homo sapiens (human). 2- amino-3-ketobutyrate coenzyme a ligase, IPI:IPI00026492.1 SW:KBL_HUMAN mitochondrial precursor (ec 2.3.1.29) T.QSIHKNLEAK.I 2 2.238 0.103 A (93%) (akb ligase) (glycine acetyltransferase). 5/2000 O75912 homo sapiens (human). diacylglycerol kinase, iota (ec 2.7.1.107) SW:KDGI_HUMAN M.PLLNDPQSVPDRLRIRVNK.I 2 2.394 0.193 P (diglyceride kinase) (dgk- iota) (dag kinase iota). 10/2001 Q14145 homo sapiens (human). kelch- SW:KEAP_HUMA IPI:IPI00106502.1 like ech-associated protein 1 (cytosolic D.SRCKDYLVKIFEELTLHK.P 2 2.361 0.206 O N (99%) inhibitor of nrf2). 10/2001 O60333 homo sapiens (human). kinesin- SW:KF1B_HUMAN E.LRIVEGQGQSSEVITPPEEISR.I 2 2.469 0.110 O like protein kif1b (klp). 10/2001 O60282 homo sapiens (human). kinesin SW:KF5C_HUMAN heavy chain isoform 5c (kinesin heavy T.TQEQVYNACAKQIVKDVLEGYN.G 2 3.123 0.253 A chain neuron-specific 2). 10/2001 P07333 homo sapiens (human). macrophage colony stimulating factor i SW:KFMS_HUMA IPI:IPI00011218.1 receptor precursor (csf-1-r) (ec V.STSSNDSFSEQDLDKEDGRPLEL.R 2 2.573 0.114 O N (96%) 2.7.1.112) (fms proto-oncogene) (c-fms) (cd115 antigen). 10/2001 P49840 homo sapiens (human). SW:KG3A_HUMA M.GGGVGASSSGGGPGGSGGGGSGGPGA IPI:IPI00028568.1 glycogen synthase kinase-3 alpha (ec 2 2.272 0.194 O N GTSFPPPGVK.L (96%) 2.7.1.37) (gsk-3 alpha). 10/2001 Q13976 homo sapiens (human). cgmp- SW:KGPA_HUMA dependent protein kinase 1, alpha S.EESKTFAMK.I 2 2.201 0.140 G N isozyme (ec 2.7.1.37) (cgk 1 alpha) (cgki- alpha). 5/2000 Q9nr64 homo sapiens (human). kelch- IPI:IPI00015995.1 SW:KHL1_HUMAN A.VGGYDGQTYLNTMESYDPQTNEW.T 2 2.441 0.145 P like protein 1. 10/2001 (91%) Q9uh77 homo sapiens (human). kelch- IPI:IPI00219546.1 SW:KHL3_HUMAN A.AVLNDLLYAVGGFDGSTGLASVEAY.S 2 2.783 0.108 O like protein 3. 10/2001 (98%) Q14807 homo sapiens (human). kinesin- SW:KID_HUMAN L.NEGSARDLRSLQR.I 1 1.941 0.080 O like dna-binding protein. 10/2001 P10721 homo sapiens (human). mast/stem cell growth factor receptor IPI:IPI00022296.1 SW:KIT_HUMAN precursor (ec 2.7.1.112) (scfr) (proto- V.DRSLYGKEDNDTLVRCPLTDPEVTN.Y 2 2.892 0.083 P (95%) oncogene tyrosine-protein kinase kit) (c- kit) (cd117 antigen). 10/2001 Q9nsk0 homo sapiens (human). SW:KLC3_HUMAN probable kinesin light chain 3 (klc 3) K.VSSPTVNTTLRN.L 1 2.068 0.154 G (fragment). 10/2001 P57682 homo sapiens (human). kruppel- like factor 3 (basic kruppel-like factor) SW:KLF3_HUMAN F.MYTSHLQQPLMVSLSEE.M 2 2.517 0.104 G (caccc-box binding protein bklf) (tef-2). 10/2001 O43240 homo sapiens (human). kallikrein 10 precursor (ec 3.4.21.-) IPI:IPI00011602.1 SW:KLKA_HUMAN A.EAALLPQNDTR.L 2 2.248 0.109 O (protease serine-like 1) (normal epithelial (93%) cell-specific 1). 10/2001 P29376 homo sapiens (human). leukocyte tyrosine kinase receptor SW:KLTK_HUMAN G.GGGACTAGGGGGGYRGGDASETDNL.W 2 2.739 0.130 O precursor (ec 2.7.1.112) (protein tyrosine kinase-1). 10/2001 Q15746 homo sapiens (human). myosin light chain kinase, smooth muscle and SW:KMLS_HUMA IPI:IPI00221258.1 non-muscle isozymes (ec 2.7.1.117) G.TPVPRITWLLNGQPIQYAR.S 2 2.441 0.167 P N (99%) (mlck) [contains: telokin (kinase related protein) (krp)]. 10/2001 P46019 homo sapiens (human). phosphorylase b kinase alpha regulatory IPI:IPI00004237.1 SW:KPB2_HUMAN K.FPISR.P 1 1.835 0.083 G chain, liver isoform (phosphorylase (95%) kinase alpha l subunit). 10/2001 P10398 homo sapiens (human). a-raf SW:KRAA_HUMA proto-oncogene serine/threonine-protein L.IQLTGQSFSTDAAGSRGGSDGTPR.G 2 2.478 0.115 G N kinase (ec 2.7.1.-) (a-raf-1) (proto- oncogene pks). 10/2001 SW:KRAF_HUMA P04049 homo sapiens (human). raf IPI:IPI00021786.1 S.NGFGFKDAVFDGS.S 2 3.017 0.193 O N proto-oncogene serine/threonine-protein (97%)
Supplementary Table 2 90 kinase (ec 2.7.1.-) (raf-1) (c-raf). 10/2001 P08922 homo sapiens (human). proto- SW:KROS_HUMA IPI:IPI00031730.1 oncogene tyrosine-protein kinase ros T.TQEIGQKTSVSVLEPAR.F 2 2.232 0.180 G N (98%) precursor (ec 2.7.1.112). 11/1997 P01598 homo sapiens (human). ig kappa IPI:IPI00003457.1 SW:KV1F_HUMAN R.ASQSINTWLAWYQQKPGK.A 2 2.368 0.173 G chain v-i region eu. 7/1999 (93%) P01603 homo sapiens (human). ig kappa SW:KV1K_HUMAN -.DIQMTQSPSTLSVSVG.D 2 3.634 0.196 G chain v-i region ka. 7/1999 SW:KV1M_HUMA P01605 homo sapiens (human). ig kappa -.DIQMTQSPSSLSVSVG.D 2 3.488 0.143 G N chain v-i region lay. 7/1999 P42704 homo sapiens (human). 130 kda IPI:IPI00001404.1 SW:L130_HUMAN leucine-rich protein (lrp 130) (gp130). Q.LEPAVEKISIMAERLANQFAIY.K 2 2.510 0.124 P (96%) 10/2001 O00515 homo sapiens (human). ladinin 1 (lad-1) (120 kda linear iga bullous IPI:IPI00186821.1 SW:LAD1_HUMAN dermatosis antigen) (97 kda linear iga A.SSRKENLRLSGVVTSRLN.L 2 2.664 0.153 A (92%) bullous dermatosis antigen) (linear iga disease antigen homolog) (lada). 1 P51826 homo sapiens (human). laf-4 SW:LAF4_HUMAN protein (lymphoid nuclear protein related T.QERPPAMAAKHSSSGHCVQNF.P 2 2.480 0.111 A to af4). 10/2001 SW:LAM1_HUMA P20700 homo sapiens (human). lamin L.EDLLAKEKDNSRRMLT.D 1 2.439 0.157 A N b1. 10/2001 SW:LAM2_HUMA Q03252 homo sapiens (human). lamin E.RARLQIEIGKLRAELDEVNKSAK.K 2 2.441 0.109 P N b2 (fragments). 10/2001 Q9uhi5 homo sapiens (human). large neutral amino acids transporter small IPI:IPI00005902.1 SW:LAT2_HUMAN Y.QPTPTKDK.D 2 2.379 0.123 O subunit 2 (l-type amino acid transporter (93%) 2). 10/2001 P98155 homo sapiens (human). very SW:LDVR_HUMA IPI:IPI00024273.1 low-density lipoprotein receptor precursor D.DKVGRHVK.M 1 2.205 0.105 A N (97%) (vldl receptor). 10/2001 O00214 homo sapiens (human). galectin-8 (gal-8) (prostate carcinoma SW:LEG8_HUMAN tumor antigen 1) (pcta-1) (po66 I.NGDIHLLEVRS.W 1 2.178 0.103 A carbohydrate-binding protein) (po66- cbp). 10/2001 P14151 homo sapiens (human). l- selectin precursor (lymph node homing SW:LEM1_HUMA IPI:IPI00218795.1 receptor) (leukocyte adhesion molecule- C.RDNYTDLVAIQNKAEIEYLEK.T 2 2.537 0.095 P N (93%) 1) (lam-1) (leukocyte surface antigen leu- 8) (tq1) (gp90-mel) (leukocyte-endothe Q9nq69 homo sapiens (human). IPI:IPI00015225.1 SW:LHX9_HUMAN P.LSPEKPALCAGCGGKISDR.Y 1 2.071 0.116 A lim/homeobox protein lhx9. 10/2001 (91%) P15018 homo sapiens (human). leukemia inhibitory factor precursor (lif) IPI:IPI00009720.1 SW:LIF_HUMAN (differentiation- stimulating factor) (d F.QKKKLGCQLLG.K 1 2.054 0.125 P (91%) factor) (melanoma-derived lpl inhibitor) (mlpli). 10/2001 P53671 homo sapiens (human). lim IPI:IPI00025698.1 SW:LIK2_HUMAN domain kinase 2 (ec 2.7.1.-) (limk-2). A.PEMLNGKSYDETVDIFSFGI.V 2 2.698 0.107 P (94%) 10/2001 P24043 homo sapiens (human). laminin SW:LMA2_HUMA IPI:IPI00218725.1 alpha-2 chain precursor (laminin m M.EKDLREKLADYK.N 2 2.296 0.128 A N (97%) chain) (merosin heavy chain). 10/2001 P07942 homo sapiens (human). laminin SW:LMB1_HUMA A.EEANLGPGVSIVERQYIQDRIPSWTGAGF IPI:IPI00013976.1 beta-1 chain precursor (laminin b1 3 3.719 0.276 A N VR.V (97%) chain). 10/2001 P55268 homo sapiens (human). laminin SW:LMB2_HUMA IPI:IPI00023988.1 beta-2 chain precursor (s-laminin). F.LDHLIWE.A 1 2.106 0.106 O N (93%) 10/2001 SW:LMG2_HUMA Q13753 homo sapiens (human). laminin IPI:IPI00220572.1 H.QDVDGWK.A 2 2.318 0.144 O N gamma-2 chain precursor. 10/2001 (97%) P58215 homo sapiens (human). lysyl IPI:IPI00011385.1 SW:LOL3_HUMAN oxidase homolog 3 precursor (ec 1.4.3.-) R.MGQGMGAIHLSE.V 1 1.908 0.082 G (95%) (lysyl oxidase-like protein 3). 10/2001 O75342 homo sapiens (human). arachidonate 12-lipoxygenase, 12r type SW:LOXR_HUMA IPI:IPI00173432.1 (ec 1.13.11.-) (epidermis-type W.MDGYETLALREATGK.T 1 2.049 0.199 A N (99%) lipoxygenase 12) (12r-lipoxygenase). 10/2001 P98164 homo sapiens (human). low- density lipoprotein receptor-related IPI:IPI00024292.1 SW:LRP2_HUMAN R.TCLADEFK.C 1 1.885 0.126 A, P protein 2 precursor (megalin) (96%) (glycoprotein 330). 10/2001 SW:LV2H_HUMAN P01711 homo sapiens (human). ig S.YTSSNSVVFGGGTK.L 2 2.284 0.123 O
Supplementary Table 2 91 lambda chain v-ii region vil. 7/1999 Q14596 homo sapiens (human). membrane component, chromosome 17, SW:M172_HUMAN surface marker 2 (ovarian carcinoma V.SDPENTTWADIEAMVKVSFDL.N 2 2.578 0.106 G antigen ca125) (1a1-3b) (next to brca1 gene 1 protein). 10/2001 P80192 homo sapiens (human). SW:M3K9_HUMA mitogen-activated protein kinase kinase IPI:IPI00216290.1 A.VAYGVAMNKLALPIPSTCPE.P 2 2.429 0.191 G N kinase 9 (ec 2.7.1.-) (mixed lineage (94%) kinase 1) (fragment). 10/2001 Q99558 homo sapiens (human). mitogen-activated protein kinase kinase SW:M3KE_HUMA kinase 14 (ec 2.7.1.37) (nf- kappa beta- H.RVKVGDIATGISSQIPAAAFSL.V 2 2.663 0.091 G N inducing kinase) (serine/threonine protein kinase nik) (hsnik). 10/2001 P51674 homo sapiens (human). IPI:IPI00019952.1 SW:M6A_HUMAN neuronal membrane glycoprotein m6-a. V.IAMVHYLMVLSANWAYVKD.A 2 2.518 0.223 P (94%) 10/2001 P20916 homo sapiens (human). myelin- IPI:IPI00179159.1 SW:MAG_HUMAN associated glycoprotein precursor. S.ISAFEGTCVSIPCRFDFPDELR.P 2 2.229 0.107 A (92%) 10/2001 P43361 homo sapiens (human). SW:MAG8_HUMA melanoma-associated antigen 8 (mage-8 I.FGIDVKEVDPAGHSYILVTCLGLSYDGLL.G 2 2.613 0.193 G N antigen). 10/2001 P22897 homo sapiens (human). SW:MANR_HUMA macrophage mannose receptor IPI:IPI00027848.1 K.SCVSLNPG.K 1 1.802 0.101 P N precursor (mmr) (cd206 antigen). (96%) 10/2001 Q16798 homo sapiens (human). nadp- SW:MAON_HUMA dependent malic enzyme, mitochondrial IPI:IPI00003970.1 A.MGIAHLLVMALEKEGVPKAEA.T 2 2.479 0.168 G N precursor (ec 1.1.1.40) (nadp-me). (98%) 10/2001 P56270 homo sapiens (human). myc- associated zinc finger protein (mazi) SW:MAZ_HUMAN A.AAAAAAAAAVAAPPTA.V 1 2.427 0.097 P (purine-binding transcription factor) (pur- 1) (zf87) (zif87). 10/2001 P33032 homo sapiens (human). SW:MC5R_HUMA melanocortin-5 receptor (mc5-r) (mc-2). E.DMGIAVEVF.L 1 2.285 0.132 P N 10/2001 Q13155 homo sapiens (human). SW:MCA2_HUMA multisynthetase complex auxiliary IPI:IPI00011916.1 V.DIAIFQ.L 1 2.074 0.111 O N component p38 (jtv-1 protein) (protein (92%) pro0992). 10/2001 P33991 homo sapiens (human). dna SW:MCM4_HUMA IPI:IPI00168673.1 replication licensing factor mcm4 (cdc21 L.YMQRLGEINVI.G 1 2.348 0.161 A N (98%) homolog) (p1-cdc21). 10/2001 P33992 homo sapiens (human). dna SW:MCM5_HUMA I.MPDKCKCVDFQTLKLQELPDAVPHGEMPR replication licensing factor mcm5 (cdc46 2 2.409 0.100 P N .H homolog) (p1-cdc46). 10/2001 P08235 homo sapiens (human). E.STKHSCSGTSFKGNPTVNPFPFMDGSYFS IPI:IPI00179419.1 SW:MCR_HUMAN 3 3.526 0.144 P mineralocorticoid receptor (mr). 10/2001 FMDDK.D (98%) P55160 homo sapiens (human). SW:MEM1_HUMA IPI:IPI00023407.1 membrane-associated protein hem-1 V.SLPLLATDPSSFYSIEKDGYNNNI.H 2 2.519 0.121 A N (98%) (hematopoietic protein 1). 10/2001 SW:MEN1_HUMA O00255 homo sapiens (human). menin. K.PEEPPPPKKP.A 1 1.950 0.121 P N 10/2001 P35240 homo sapiens (human). merlin SW:MERL_HUMA IPI:IPI00216128.1 (schwannomin) (neurofibromin 2). K.PLDKKIDVFK.F 2 2.311 0.187 A N (95%) 10/2001 P08581 homo sapiens (human). hepatocyte growth factor receptor IPI:IPI00216014.1 SW:MET_HUMAN precursor (ec 2.7.1.112) (met proto- L.QRVDLFMGQFSEV.L 2 2.663 0.094 A (96%) oncogene tyrosine kinase) (c-met) (hgf receptor) (hgf-sf receptor). 10/2001 T.KSFISGGSTITGVGKNLNSVSVPR.M 2 2.257 0.244 P31153 homo sapiens (human). s- adenosylmethionine synthetase gamma SW:METK_HUMA IPI:IPI00010157.1 form (ec 2.5.1.6) (methionine P.DIAQGVHLDR.N 2 2.246 0.127 G N (96%) adenosyltransferase) (adomet synthetase) (mat-ii). 10/2001 Q04900 homo sapiens (human). putative SW:MG24_HUMA mucin core protein 24 precursor (multi- S.APVTSLPLVTTPAPETCEGRNS.C 2 3.492 0.137 G, O N glycosylated core protein 24) (mgc-24) (muc-24) (cd164 antigen). 10/2001 O43451 homo sapiens (human). IPI:IPI00182895.1 SW:MGA_HUMAN A.KGELFWDDGETKDTVANK.V 2 2.320 0.127 O maltase-glucoamylase, intestinal (97%)
Supplementary Table 2 92 [includes: maltase (ec 3.2.1.20) (alpha- glucosidase); glucoamylase (ec 3.2.1.3) (glucan 1,4-alpha- glucosidase)]. 10/2001 P41594 homo sapiens (human). SW:MGR5_HUMA IPI:IPI00220277.1 metabotropic glutamate receptor 5 P.AAGAQAAGDAARESPAA.G 2 2.502 0.198 O N (92%) precursor. 10/2001 O15303 homo sapiens (human). SW:MGR6_HUMA IPI:IPI00169239.1 metabotropic glutamate receptor 6 A.GSVRLAGGLTLGGLFPVHARGAAG.R 2 2.612 0.082 O N (97%) precursor. 10/2001 O00222 homo sapiens (human). SW:MGR8_HUMA A.VYSMAYALHNMHKDLCPGYIGLCPRMSTI IPI:IPI00219108.1 metabotropic glutamate receptor 8 3 3.751 0.218 P N DGKELL.G (97%) precursor. 10/2001 Q16674 homo sapiens (human). melanoma derived growth regulatory SW:MIA_HUMAN T.LKPGKVDVK.T 1 1.992 0.123 A protein precursor (melanoma inhibitory activity). 10/2001 Q16659 homo sapiens (human). mitogen-activated protein kinase 6 (ec SW:MK06_HUMA IPI:IPI00006487.1 2.7.1.-) (extracellular signal- regulated N.NSGEFLFNKQ.L 2 3.427 0.101 O N (97%) kinase 3) (erk-3) (map kinase isoform p97) (p97-mapk). 10/2001 P49137 homo sapiens (human). map SW:MKK2_HUMA kinase-activated protein kinase 2 (ec IPI:IPI00180556.1 L.IRNLLKTEPTQRMTITEF.M 2 2.681 0.087 P N 2.7.1.-) (mapk-activated protein kinase 2) (97%) (mapkap kinase 2) (mapkapk-2). 10/2001 Q14849 homo sapiens (human). mln 64 IPI:IPI00000865.1 SW:ML64_HUMAN A.VTTLVSSAFLIVKVILSELLSKGAF.G 2 2.597 0.142 O protein (cab1 protein). 10/2001 (92%) Q9uhc1 homo sapiens (human). dna SW:MLH3_HUMA IPI:IPI00005811.1 mismatch repair protein mlh3 (mutl V.LQQVDNKFIACLMSTK.T 2 2.253 0.163 G N (96%) protein homolog 3). 10/2001 P10916 homo sapiens (human). myosin SW:MLRV_HUMA regulatory light chain 2, IPI:IPI00216798.1 V.DQMFAAFPPDVTG.N 2 2.584 0.103 A N ventricular/cardiac muscle isoform (mlc- (99%) 2). 10/2001 Q9nre1 homo sapiens (human). matrix SW:MM26_HUMA metalloproteinase-26 precursor (ec IPI:IPI00016402.1 L.FLVATHEIGHSLG.L 1 2.128 0.158 A N 3.4.24.-) (mmp-26) (matrilysin-2) (95%) (endometase). 10/2001 O60669 homo sapiens (human). SW:MOT2_HUMA IPI:IPI00030996.1 monocarboxylate transporter 2 (mct 2). H.TTYSEIAWISSIMLAVMYAGGPVS.S 2 3.042 0.132 G N (94%) 10/2001 Q14168 homo sapiens (human). maguk SW:MPP2_HUMA IPI:IPI00217808.1 p55 subfamily member 2 (mpp2 protein) S.LAKVIMVLWFMQQNV.F 2 2.403 0.163 O N (98%) (discs, large homolog 2). 10/2001 Q10713 homo sapiens (human). mitochondrial processing peptidase SW:MPPA_HUMA IPI:IPI00166749.1 alpha subunit, mitochondrial precursor A.QYTGGIAKLERD.M 2 2.592 0.112 P N (93%) (ec 3.4.24.64) (alpha-mpp) (p-55) (ha1523). 10/2001 O75352 homo sapiens (human). mannose-p-dolichol utilization defect 1 SW:MPU1_HUMA G.SLARIFTSIQETGDPLMAGTFVVSSLCNGLI protein (suppressor of lec15 and lec35 3 3.750 0.271 P N AAQL.L glycosylation mutation homolog) (sl15). 10/2001 SW:MSE5_HUMA Q00587 homo sapiens (human). serum T.MHVGRGGDVF.G 1 2.043 0.088 O N protein mse55. 10/2001 P80294 homo sapiens (human). SW:MT1H_HUMA K.CKKCKCTSCKKSCCSCCPLGCAKCAQGCI metallothionein-ih (mt-1h) 3 3.516 0.143 P N CKGA.S (metallothionein-0) (mt-0). 5/2000 SW:MTN2_HUMA O00339 homo sapiens (human). matrilin- IPI:IPI00011291.1 R.LEEMTQRMEALENRL.R 1 2.195 0.168 G N 2 precursor. 10/2001 (98%) Q15012 homo sapiens (human). SW:MTRP_HUMA lysosomal-associated transmembrane L.MAILLTVEVTHPNS.M 2 2.631 0.100 G, P N protein 4a (golgi 4-transmembrane spanning transporter mtp). 10/2001 P43121 homo sapiens (human). cell surface glycoprotein muc18 precursor SW:MU18_HUMA (melanoma-associated antigen muc18) K.TELVVEVKSDKLPEEMGLLQGSSGDKRAP IPI:IPI00016334.1 3 3.589 0.138 A N (melanoma-associated antigen a32) (s- GDQG.E (92%) endo 1 endothelial- associated antigen) (cd1 Q99836 homo sapiens (human). myeloid SW:MY88_HUMA differentiation primary response protein L.PGTCVWSIASELIEKR.C 2 2.419 0.114 O N myd88. 10/2001 SW:MYBA_HUMA P10243 homo sapiens (human). myb- IPI:IPI00019992.1 A.KRSRSEDEDDDLQYADHDY.E 2 2.516 0.104 G N related protein a (a-myb). 10/2001 (93%) Supplementary Table 2 93 Q9ukx2 homo sapiens (human). myosin SW:MYH2_HUMA heavy chain, skeletal muscle, adult 2 IPI:IPI00179548.1 A.RVEYQRMVER.R 1 2.158 0.182 G N (myosin heavy chain iia) (myhc-iia). (93%) 10/2001 P35580 homo sapiens (human). myosin heavy chain, nonmuscle type b (cellular SW:MYHA_HUMA myosin heavy chain, type b) (nonmuscle L.LEDQNSKFIKEK.K 2 2.409 0.150 O N myosin heavy chain-b) (nmmhc-b). 10/2001 P35749 homo sapiens (human). myosin SW:MYHB_HUMA heavy chain, smooth muscle isoform S.FLGILDIAGFEIFEVNSFEQL.C 2 2.436 0.109 P N (smmhc). 10/2001 Q9ubc5 homo sapiens (human). brush SW:MYHL_HUMA IPI:IPI00220422.1 border myosin i (bbm-i) (bbmi) (myosin i S.RILLLTKGHVILTDTKKSQAK.I 2 2.486 0.163 A N (95%) heavy chain) (mihc). 10/2001 P54296 homo sapiens (human). SW:MYM2_HUMA myomesin 2 (m-protein) (165 kda titin- IPI:IPI00005587.1 D.MAPPQQAKPKLIPASASAA.G 1 2.068 0.088 G N associated protein) (165 kda connectin- (96%) associated protein). 10/2001 P25189 homo sapiens (human). myelin SW:MYP0_HUMA p0 protein precursor (myelin protein zero) G.AVGSRVTLHCSFWSSEW.V 1 2.076 0.128 A N (myelin peripheral protein) (mpp). 10/2001 Q00872 homo sapiens (human). myosin- SW:MYPS_HUMA binding protein c, slow-type (slow mybp- IPI:IPI00181712.1 V.WGENVALTWTP.P 1 2.238 0.101 A N c) (c-protein, skeletal muscle slow- (92%) isoform). 7/1999 Q01538 homo sapiens (human). myelin SW:MYT1_HUMA transcription factor 1 (myt1) (myti) T.SHTSAQKAPELR.G 2 2.292 0.154 O N (proteolipid protein binding protein) (plpb1). 10/2001 P57740 homo sapiens (human). nuclear pore complex protein nup107 IPI:IPI00181534.1 SW:N107_HUMAN A.EIYNQCEE.Q 2 2.529 0.112 O (nucleoporin nup107) (107 kda (96%) nucleoporin). 10/2001 Q9y2n3 homo sapiens (human). nuclear envelope pore membrane protein pom SW:N121_HUMAN P.QPAPAPEGQDLRNRPGRRPPAR.P 2 2.335 0.117 P 121 (pore membrane protein of 121 kda) (p145). 10/2001 O75694 homo sapiens (human). nuclear pore complex protein nup155 IPI:IPI00164856.1 SW:N155_HUMAN L.LVLATPVDIVILGLSYA.N 2 2.525 0.236 G (nucleoporin nup155) (155 kda (96%) nucleoporin). 10/2001 P35658 homo sapiens (human). nuclear pore complex protein nup214 SW:N214_HUMAN S.PGVMGTSVATSASKII.P 2 2.809 0.113 O (nucleoporin nup214) (214 kda nucleoporin) (can protein). 10/2001 O43805 homo sapiens (human). nuclear SW:NA14_HUMAN T.EAAYLKILESF.Q 2 2.529 0.162 O autoantigen of 14 kda. 10/2001 Q9c000 homo sapiens (human). nacht-, lrr- and pyd-containing protein 2 (death IPI:IPI00029633.1 SW:NAL1_HUMAN effector filament- forming ced-4-like R.NLKELDLSGNSLSHSAVKSLCK.T 2 2.561 0.095 G (92%) apoptosis protein) (nucleotide-binding domain and caspase recruitment do P49321 homo sapiens (human). nuclear SW:NASP_HUMA IPI:IPI00157149.2 autoantigenic sperm protein (nasp). S.GFTPGGGGSSVSMIASR.K 2 2.366 0.103 G N (91%) 10/2001 V.VTSENEAGKAVLEQLVGQEVPPAEE.S 2 2.445 0.230 P13591 homo sapiens (human). neural SW:NCA1_HUMA cell adhesion molecule, 140 kda isoform IPI:IPI00177913.1 V.EAKPECQETETKPAPAEVKTVPN.D 2 2.560 0.104 A N precursor (n-cam 140) (ncam-140) (cd56 (96%) antigen). 10/2001 P80303 homo sapiens (human). SW:NCB2_HUMA nucleobindin 2 precursor (dna-binding F.DHLNHLNPDKFESTDLDM.L 2 2.549 0.129 O N protein nefa). 10/2001 Q15596 homo sapiens (human). nuclear SW:NCO2_HUMA IPI:IPI00018251.1 receptor coactivator 2 (transcriptional V.KQIRQIKEQ.E 1 2.068 0.093 G N (91%) intermediary factor 2). 10/2001 P36610 homo sapiens (human), rattus norvegicus (rat), and gallus gallus SW:NCS1_HUMA (chicken). neuronal calcium sensor 1 F.IQALSVTSRGTLDEKLRWAFK.L 2 2.486 0.138 G N (ncs-1) (frequenin homolog) (frequenin- like protein) (frequenin-like ubiquitous Q92886 homo sapiens (human). SW:NDF3_HUMA neurogenic differentiation factor 3 S.GSDLSGFLTDEEDCARLQQ.A 2 3.153 0.167 G N (neurogenic basic-helix-loop- helix
Supplementary Table 2 94 protein) (neurogenin 1). 10/2001 P29120 homo sapiens (human). neuroendocrine convertase 1 precursor SW:NEC1_HUMA IPI:IPI00020394.1 (ec 3.4.21.93) (nec 1) (pc1) (prohormone G.KTVEGPGRLAQKAFEYGVK.Q 2 2.298 0.255 A N (95%) convertase 1) (proprotein convertase 1). 10/2001 SW:NED4_HUMA P46934 homo sapiens (human). nedd-4 IPI:IPI00009322.1 L.KARLWIEFDGEKGLDYG.G 2 2.940 0.083 P N protein (ec 6.3.2.-) (fragment). 10/2001 (94%) P51956 homo sapiens (human). SW:NEK3_HUMA serine/threonine-protein kinase nek3 (ec IPI:IPI00178082.1 I.VMEYCDGGDLMQKIKQQKGKLF.P 2 2.598 0.103 O N 2.7.1.-) (nima-related protein kinase 3) (96%) (hspk 36) (fragment). 10/2001 Q99435 homo sapiens (human). protein kinase c-binding protein nell2 precursor IPI:IPI00015260.1 SW:NEL2_HUMAN P.ESHQITLSHSCCK.V 2 2.483 0.103 P (nel-like protein 2) (nel-related protein 2). (98%) 10/2001 Q13469 homo sapiens (human). nuclear SW:NFC2_HUMA factor of activated t-cells, cytoplasmic 2 (t IPI:IPI00017627.2 A.PGTTRPGPPPVSQGQRLSPGSYP.T 2 2.423 0.253 O N cell transcription factor nfat1) (nfat pre- (91%) existing subunit) (nf-atp). 10/2001 Q12857 homo sapiens (human). nuclear factor 1 a-type (nuclear factor 1/a) (nf1-a) IPI:IPI00217633.1 SW:NFIA_HUMAN (nfi-a) (nf-i/a) (ccaat-box binding D.SPGEEPFYTGQGRSPGSGSQSSGW.H 2 2.444 0.131 O (91%) transcription factor) (ctf) (tggca-binding protein). 10/2001 P08651 homo sapiens (human). nuclear factor 1 c-type (nuclear factor 1/c) (nf1-c) IPI:IPI00218037.1 SW:NFIC_HUMAN (nfi-c) (nf-i/c) (ccaat-box binding A.SQQPGPLNGSGQLKMPSHCLS.A 2 2.554 0.125 P (93%) transcription factor) (ctf) (tggca-binding protein). 10/2001 P07197 homo sapiens (human). neurofilament triplet m protein (160 kda SW:NFM_HUMAN neurofilament protein) (neurofilament A.KSDQAEEGGSEKEGSSEKEE.G 2 2.961 0.146 G, P medium polypeptide) (nf-m) (neurofilament 3). 10/2001 P29371 homo sapiens (human). SW:NK3R_HUMA neuromedin k receptor (nkr) (neurokinin E.TWIDGGGGVGADAVNLTASLAAGAA.T 2 2.407 0.121 G N b receptor) (nk-3 receptor) (nk-3r). 10/2001 P55011 homo sapiens (human). SW:NKC1_HUMA bumetanide-sensitive sodium- IPI:IPI00185626.1 A.VPSVPEDAAPASRDGGGVR.D 1 2.140 0.164 A N (potassium)-chloride cotransporter 1 (95%) (basolateral na-k-cl symporter). 11/1997 SW:NMBL_HUMA Q9y6r0 homo sapiens (human). numb- A.PAPELDPFEAQ.W 1 2.023 0.121 O N like protein (numb-r). 10/2001 Q13224 homo sapiens (human). glutamate [nmda] receptor subunit SW:NME2_HUMA epsilon 2 precursor (n-methyl d- IPI:IPI00012300.1 V.ELVAMNETDPK.S 2 2.372 0.129 O N aspartate receptor subtype 2b) (nr2b) (97%) (nmdar2b) (n-methyl-d-aspartate receptor subunit 3) (n P30419 homo sapiens (human). glycylpeptide n-tetradecanoyltransferase SW:NMT1_HUMA 1 (ec 2.3.1.97) (peptide n- IPI:IPI00221208.1 D.TEKKMVEINFLCVHK.K 2 2.504 0.193 A, O, P N myristoyltransferase 1) (myristoyl- (96%) coa:protein n-myristoyltransferase 1) (nmt 1). 10/2001 P46087 homo sapiens (human). SW:NOL1_HUMA proliferating-cell nucleolar antigen p120 L.QINVDEEPFVLPPAGEM.E 2 2.450 0.125 O N (proliferation-associated nucleolar protein p120). 10/2001 V.PAAPHQQRGRNLSPGATASCCY.L 2 2.572 0.312 P29474 homo sapiens (human). nitric- oxide synthase, endothelial (ec SW:NOS3_HUMA 1.14.13.39) (ec-nos) (nos, type iii) (nosiii) Q.RCPGRGDFRIWNSQLVRY.A 2 2.510 0.181 A, G, P N (endothelial nos) (enos) (constitutive nos) (cnos). 5/2000 Q9y5s8 homo sapiens (human). nadph oxidase homolog 1 (nox-1) (noh-1) SW:NOX1_HUMA IPI:IPI00001756.1 (nadh/nadph mitogenic oxidase subunit V.AYMICLHTAIHIIAHLFNFDC.Y 2 2.427 0.160 P N (96%) p65-mox) (mitogenic oxidase 1) (mox1). 10/2001 Q9ui15 homo sapiens (human). neuronal SW:NP25_HUMAN A.ENPRCLLLPPPVHLELCKDSASVFLS.S 2 2.612 0.139 A, P protein np25. 10/2001 SW:NPA2_HUMA Q99743 homo sapiens (human). A.SSRSSHKSSHTAMSEPTSTPTKLM.A 2 2.433 0.135 O N neuronal pas domain protein 2 (neuronal
Supplementary Table 2 95 pas2) (member of pas protein 4) (mop4). 10/2001 O75323 homo sapiens (human). SW:NPS2_HUMA nipsnap2 protein (glioblastoma amplified Q.DGNEAVGGFFSQIGQL.Y 1 2.075 0.096 P N sequence). 10/2001 Q15818 homo sapiens (human). SW:NPX1_HUMA neuronal pentraxin i precursor (np-i) Q.LTFPLRTNYMYAKVKK.S 2 2.274 0.151 A N (np1). 10/2001 Q15233 homo sapiens (human). 54 kda nuclear rna- and dna-binding protein (p54(nrb)) (p54nrb) (55 kda nuclear SW:NR54_HUMAN H.NQEVQKRKQLE.L 2 3.383 0.129 P protein) (nmt55) (non-pou domain- containing octamer- binding protein) (dna-bind Q13133 homo sapiens (human). SW:NRH3_HUMA oxysterols receptor lxr-alpha (liver x IPI:IPI00011892.2 S.AVELWKPGAQDASSQAQGGSSCIL.R 2 2.500 0.101 A N receptor alpha) (nuclear orphan receptor (93%) lxr-alpha). 10/2001 Q14994 homo sapiens (human). orphan nuclear receptor nr1i3 (constitutive SW:NRI3_HUMAN A.ELRSINEAYGYQIQHIQ.G 2 2.702 0.081 A androstane receptor) (car) (orphan nuclear receptor mb67). 10/2001 P49279 homo sapiens (human). natural SW:NRM1_HUMA resistance-associated macrophage N.IESDLQAGAVAGFK.L 2 2.371 0.119 A N protein 1 (nramp 1). 10/2001 P34134 homo sapiens (human). SW:NT6G_HUMA neurotrophin-6 gamma (nt-6 gamma) I.FPQVVLSRGAAAGPPL.V 2 2.807 0.156 G N (fragment). 5/2000 Q12908 h ileal sodium/bile acid cotransporter (ileal na(+)/bile acid SW:NTCI_HUMAN cotransporter) (na+ dependent ileal bile A.ILIVLIAVVGGILYQSAWIIA.P 2 2.400 0.156 O acid transporter) (ileal sodium-dependent bile acid transporter) (isbt) (sodiu P30989 homo sapiens (human). SW:NTR1_HUMA neurotensin receptor type 1 (nt-r-1) (high- IPI:IPI00028150.1 T.ALNVASLSVERYLA.I 1 2.462 0.172 G N affinity levocabastine- insensitive (92%) neurotensin receptor) (ntrh). 10/2001 P52948 homo sapiens (human). nuclear SW:NU98_HUMAN pore complex protein nup98 (nucleoporin D.EPSLANGAFMPKKSIKKLVLK.N 2 2.210 0.170 O nup98) (98 kda nucleoporin). 10/1996 Q14249 homo sapiens (human). SW:NUCG_HUMA IPI:IPI00029607.2 endonuclease g, mitochondrial precursor V.PTHFFKVLILEAAGGQ.I 2 2.679 0.144 O N (99%) (ec 3.1.30.-) (endo g). 10/2001 Q15619 homo sapiens (human). SW:O1C1_HUMA IPI:IPI00169219.1 olfactory receptor 1c1 (olfactory receptor V.GDLLALTPLVCILVSY.G 2 2.465 0.314 O N (99%) tpcr27). 10/2001 O76000 homo sapiens (human). IPI:IPI00008676.1 SW:O2B3_HUMAN olfactory receptor 2b3 (olfactory receptor F.GNSVLQSSLTLNMPRC.G 2 2.425 0.103 G (95%) 6-4) (or6-4) (hs6m1-1). 10/2001 Q9gzk4 homo sapiens (human). olfactory SW:O2H1_HUMA receptor 2h1 (hs6m1-16) (olfactory IPI:IPI00026293.1 S.FLGCSVQLFI.F 2 2.754 0.083 O, P N receptor 6-2) (or6-2) (olfr42a- (95%) 9004.14/9026.2). 10/2001 T.LVGNTLIILLSVLYPRLHSPMYF.F 2 2.748 0.095 P29728 homo sapiens (human). 2'-5'- oligoadenylate synthetase 2 (ec 2.7.7.-) SW:OAS2_HUMA ((2-5')oligo(a) synthetase 2) (2-5a L.NESVSFDVLPAFNALGQLSSGS.T 2 2.695 0.184 O N synthetase 2) (p69 oas / p71 oas) (p69oas / p71oas). 10/2001 P14859 homo sapiens (human). SW:OCT1_HUMA octamer-binding transcription factor 1 T.NGLDFQKQPVPVGGAISTAQAQA.F 2 2.425 0.141 P N (otf-1) (nf-a1). 10/2001 P36957 homo sapiens (human). dihydrolipoamide succinyltransferase SW:ODO2_HUMA component of 2-oxoglutarate IPI:IPI00183043.1 T.LRKTGAAPAKAKPAEAPA.A 2 2.670 0.260 P N dehydrogenase complex, mitochondrial (98%) precursor (ec 2.3.1.61) (e2) (e2k). 10/2001 O94826 homo sapiens (human). SW:OM70_HUMA mitochondrial precursor proteins import I.EIDNKCDFAYE.T 1 2.049 0.099 A N receptor (translocase of outer membrane tom70). 10/2001 O95948 homo sapiens (human). one cut SW:ONC2_HUMA domain family member 2 (onecut-2 A.RGGGSGGGGGGGGGGGGGGPGHEQ.E 2 2.545 0.240 A N transcription factor) (oc-2). 10/2001 SW:ORC1_HUMA Q13415 homo sapiens (human). origin L.VVLAIANTM.D 1 2.114 0.089 P IPI:IPI00013215.1
Supplementary Table 2 96 N recognition complex subunit 1 (93%) (replication control protein 1). 7/1999 Q9ubd5 homo sapiens (human). origin SW:ORC3_HUMA recognition complex subunit 3 (origin IPI:IPI00002532.1 Y.VEKQASEKQV.A 2 2.426 0.142 O N recognition complex subunit latheo). (98%) 10/2001 SW:ORC4_HUMA O43929 homo sapiens (human). origin IPI:IPI00015164.1 L.SEDRSVQEVLQKHFNISK.N 2 2.228 0.182 O N recognition complex subunit 4. 7/1999 (96%) Q9y3b8 homo sapiens (human). oligoribonuclease, mitochondrial IPI:IPI00217330.1 SW:ORN_HUMAN A.EGPNLIIKQ.P 1 2.031 0.153 A precursor (ec 3.1.-.-) (small fragment (92%) nuclease) (cgi-114). 10/2001 Q9y4l1 homo sapiens (human). 150 kda SW:OXRP_HUMA IPI:IPI00000877.1 oxygen-regulated protein precursor N.TISSLFGGGTTPDAK.E 2 2.216 0.105 A N (91%) (orp150). 10/2001 Q04671 homo sapiens (human). p SW:P_HUMAN protein (melanocyte-specific transporter L.RGSVETQVTIATAILAGVYA.L 2 2.412 0.205 P protein). 10/2001 P42336 homo sapiens (human). phosphatidylinositol 3-kinase catalytic SW:P11A_HUMAN subunit, alpha isoform (ec 2.7.1.137) F.GHFLDHKKKK.F 2 2.269 0.154 O, P (pi3-kinase p110 subunit alpha) (ptdins- 3-kinase p110) (pi3k). 10/2001 P48736 homo sapiens (human). phosphatidylinositol 3-kinase catalytic subunit, gamma isoform (ec 2.7.1.137) IPI:IPI00216837.1 SW:P11G_HUMAN I.LQSFFTKMAKKKSL.M 1 2.263 0.124 G (pi3-kinase p110 subunit gamma) (97%) (ptdins-3-kinase p110) (pi3k) (pi3kgamma). 10/200 P35813 homo sapiens (human). protein SW:P2CA_HUMA phosphatase 2c alpha isoform (ec IPI:IPI00020950.1 K.VSPEAVKKEAELDKYLECRVEEIIK.K 2 2.547 0.113 G N 3.1.3.16) (pp2c-alpha) (ia) (protein (97%) phosphatase 1a). 10/2001 P49593 homo sapiens (human). putative SW:P2CH_HUMA IPI:IPI00060695.1 protein phosphatase 2c (ec 3.1.3.16) L.LQTDLSEFR.K 2 2.436 0.110 P N (92%) (pp2c). 10/2001 Q93086 homo sapiens (human). p2x R.QNVCAENEGIPDGACSKDSDCHAGEAVT IPI:IPI00217666.1 SW:P2X5_HUMAN purinoceptor 5 (atp receptor) (p2x5) 3 3.502 0.114 G AGNGVK.T (94%) (purinergic receptor). 10/2001 P09131 homo sapiens (human). p3 SW:P3_HUMAN A.YRMGVFILAG.I 2 2.422 0.126 P protein. 10/2001 Q09472 homo sapiens (human). e1a- IPI:IPI00155855.1 SW:P300_HUMAN A.DTQPEDISESKVEDCKMESTETEERS.T 2 2.625 0.266 A associated protein p300. 7/1999 (95%) V.QDAASKHKQLSELLRSGSSPNLNMGVGG 2 2.415 0.129 PGQVMAS.Q P13674 homo sapiens (human). prolyl 4- SW:P4HA_HUMA IPI:IPI00009923.1 hydroxylase alpha subunit precursor (ec I.DKVSVLDY.L 1 2.116 0.096 A N (97%) 1.14.11.2). 10/2001 Q13310 homo sapiens (human). polyadenylate-binding protein 4 (poly(a) binding protein 4) (pabp 4) (inducible IPI:IPI00186095.1 SW:PAB4_HUMAN T.DSCQSGGVPTA.V 1 2.097 0.126 O poly(a)-binding protein) (ipabp) (95%) (activated-platelet protein-1) (app-1). 10/200 P29122 homo sapiens (human). paired basic amino acid cleaving enzyme 4 SW:PAC4_HUMA IPI:IPI00217335.1 precursor (ec 3.4.21.-) (subtilisin/kexin- T.SISHPRRGDLQIYLVSPSGTK.S 2 2.325 0.202 O N (99%) like protease pace4) (subtilisin-like proprotein convertase 4) (spc4). 10/2 Q13153 homo sapiens (human). serine/threonine-protein kinase pak 1 (ec IPI:IPI00011915.1 SW:PAK1_HUMAN V.GSKDAGTLNHGSKPLPPNPEE.K 2 2.521 0.174 A 2.7.1.-) (p21-activated kinase 1) (pak-1) (93%) (p65-pak) (alpha-pak). 10/2001 Q9um63 homo sapiens (human). zinc IPI:IPI00008480.1 SW:PAL1_HUMAN finger protein plagl1 (pleiomorphic E.SLQTGDLLSTFHTISPSFQLKA.A 2 2.528 0.189 P (96%) adenoma-like protein 1). 10/2001 Q02962 homo sapiens (human). paired IPI:IPI00220545.1 SW:PAX2_HUMAN V.FVNGRPLPDVVRQRIVELAHQGVR.P 2 2.400 0.219 A box protein pax-2. 10/2001 (96%) P40426 homo sapiens (human). pre-b- IPI:IPI00215866.1 SW:PBX3_HUMAN cell leukemia transcription factor-3 A.AKTAVTAAHAVAAAVQN.N 2 2.408 0.120 P (94%) (homeobox protein pbx3). 5/2000 Q15366 homo sapiens (human). poly(rc)- SW:PCB2_HUMA IPI:IPI00216689.1 binding protein 2 (alpha-cp2) (hnrnp-e2). L.TKLHQLAMQQSHFPMTHGN.T 2 2.667 0.128 A N (99%) 10/2001 Q9ulw8 homo sapiens (human). protein- SW:PDI3_HUMAN D.EQVKTISINQVLSNKDLINY.N 2 2.855 0.114 A arginine deiminase type iii (ec 3.5.3.15)
Supplementary Table 2 97 (peptidylarginine deiminase iii). 10/2001 P98160 homo sapiens (human). basement membrane-specific heparan SW:PGBM_HUMA IPI:IPI00024284.2 sulfate proteoglycan core protein A.PGALLLALLLHGRLLAVTHGLR.A 2 2.214 0.230 P N (97%) precursor (hspg) (perlecan) (plc). 10/2001 P16112 homo sapiens (human). aggrecan core protein precursor SW:PGCA_HUMA IPI:IPI00216489.1 (cartilage-specific proteoglycan core G.WLRDQTVRYPIVSPR.T 2 2.254 0.144 G N (95%) protein) (cspcp) (chondroitin sulfate proteoglycan core protein 1). 10/2001 P09619 homo sapiens (human). beta SW:PGDR_HUMA platelet-derived growth factor receptor G.QVVEATAHGLSHSQ.A 2 3.097 0.112 O N precursor (ec 2.7.1.112) (pdgf-r-beta) (cd140b antigen). 10/2001 P23219 homo sapiens (human). prostaglandin g/h synthase 1 precursor SW:PGH1_HUMA IPI:IPI00010677.1 (ec 1.14.99.1) (cyclooxygenase -1) (cox- F.KDGKLKYQ.V 1 2.188 0.086 P N (95%) 1) (prostaglandin-endoperoxide synthase 1) (prostaglandin h2 synthase 1) (pgh sy P07205 homo sapiens (human). SW:PGK2_HUMA phosphoglycerate kinase, testis specific L.GDVYVNDAFGTAH.R 1 2.087 0.110 G N (ec 2.7.2.3). 10/2001 Q9uq90 homo sapiens (human). IPI:IPI00010483.1 SW:PGN_HUMAN paraplegin (ec 3.4.24.-) (spastic V.LLLLLRALGRGPGPGPR.P 2 2.219 0.117 G (93%) paraplegia protein 7). 10/2001 P21810 homo sapiens (human). SW:PGS1_HUMA bone/cartilage proteoglycan i precursor N.KLARVPSGLPDLKLL.Q 1 2.136 0.167 A N (biglycan) (pg-s1). 10/2001 Q92696 homo sapiens (human). rab geranylgeranyltransferase alpha subunit SW:PGTA_HUMA (ec 2.5.1.-) (rab geranyl- IPI:IPI00022664.1 L.ELVQNAFFTDPND.Q 1 2.031 0.092 G N geranyltransferase alpha subunit) (rab gg (97%) transferase alpha) (rab ggtase alpha). 10/2001 P39687 homo sapiens (human). potent heat-stable protein phosphatase 2a SW:PHA1_HUMA IPI:IPI00025849.1 inhibitor i1pp2a (hla-dr associated protein N.VFKLLPQLTYLDGYDRDDK.E 2 2.208 0.140 A N (93%) i) (phapi) (acidic nuclear phosphoprotein pp32) (cerebellar leucine rich O43189 homo sapiens (human). phd IPI:IPI00064665.1 SW:PHF1_HUMAN A.RCLPSSPIRMFASFHPSASTAGTSGD.S 2 2.405 0.109 G finger protein 1 (phf1 protein). 10/2001 (98%) Q9nq66 homo sapiens (human). 1- phosphatidylinositol-4,5-bisphosphate IPI:IPI00219563.1 SW:PIB1_HUMAN phosphodiesterase beta 1 (ec 3.1.4.11) L.EKSAKK.D 1 1.839 0.103 P (91%) (plc-beta-1) (phospholipase c-beta-1) (plc-i) (plc-154). 10/2001 P16885 homo sapiens (human). 1- phosphatidylinositol-4,5-bisphosphate IPI:IPI00031142.2 SW:PIG2_HUMAN phosphodiesterase gamma 2 (ec P.NFLAHATYPIKAVK.S 2 2.561 0.125 G (99%) 3.1.4.11) (plc-gamma-2) (phospholipase c-gamma-2) (plc-iv). 10/2001 P35988 human adenovirus type 12. SW:PIV6_ADE12 minor capsid protein vi precursor. E.PTIADPVGSVPVASVPVA.S 2 2.452 0.176 A 10/1996 Q13393 homo sapiens (human). phospholipase d1 (ec 3.1.4.4) (pld 1) IPI:IPI00218799.1 SW:PLD1_HUMAN (choline phosphatase 1) V.VLGYLDDPSEDIQDPVSDKFFKEV.W 2 2.508 0.111 O (98%) (phosphatidylcholine-hydrolyzing phospholipase d1) (hpld1). 10/2001 P53350 homo sapiens (human). serine/threonine-protein kinase plk (ec SW:PLK1_HUMAN L.HRNRVIHRDLK.L 2 2.721 0.097 O, P 2.7.1.-) (plk-1) (serine- threonine protein kinase 13) (stpk13). 10/2001 O15162 homo sapiens (human). phospholipid scramblase 1 (pl scramblase 1) (erythrocyte phospholipid SW:PLS1_HUMAN A.AGVPWMPAPQP.P 2 2.411 0.140 A scramblase) (ca2+ dependent phospholipid scramblase 1) (mmtra1b). 10/2001 Q14651 homo sapiens (human). i-plastin IPI:IPI00032304.1 SW:PLSI_HUMAN E.LGKNKAKFSLVGIA.G 2 2.746 0.095 P (intestine-specific plastin). 10/2001 (96%) SW:PM5P_HUMA Q15155 homo sapiens (human). protein IPI:IPI00221351.1 T.EAKIQSTVTQPGGK.F 2 2.230 0.170 G N pm5 precursor. 10/2001 (95%) SW:PMGE_HUMA P07738 homo sapiens (human). E.WVPVESSWR.L 2 2.457 0.122 A N bisphosphoglycerate mutase (ec 5.4.2.4)
Supplementary Table 2 98 (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (bpgm) (ec 5.4.2.1) (ec 3.1.3.13) (bpg P54278 homo sapiens (human). pms1 SW:PMS2_HUMA IPI:IPI00005543.1 protein homolog 2 (dna mismatch repair W.NCPHGRPTMRHIANLGV.I 2 2.439 0.120 G N (98%) protein pms2). 10/2001 P11086 homo sapiens (human). SW:PNMT_HUMA phenylethanolamine n-methyltransferase IPI:IPI00003466.1 R.VLPIDVHQP.Q 1 1.822 0.092 A N (ec 2.1.1.28) (pnmtase) (noradrenaline n- (95%) methyltransferase). 10/2001 Q07869 homo sapiens (human). SW:PPAR_HUMA IPI:IPI00020097.1 peroxisome proliferator activated T.VTELTEFAK.A 1 2.110 0.088 A N (96%) receptor alpha (ppar-alpha). 10/2001 Q03181 homo sapiens (human). peroxisome proliferator activated SW:PPAS_HUMA IPI:IPI00009330.1 receptor beta (ppar-beta) (ppar-delta) R.SILTGKASHTAPFVIHDIETL.W 2 2.471 0.110 A N (95%) (nuclear hormone receptor 1) (nuc1) (nuci). 10/2001 P10696 homo sapiens (human). alkaline phosphatase, placental-like precursor (ec SW:PPBN_HUMA A.AKKLQPAQTAAKNLIIFLGDGMGVSTVTAA IPI:IPI00007289.1 3.1.3.1) (nagao isozyme) (germ-cell 3 3.973 0.097 A N RIL.K (95%) alkaline phosphatase) (plap-like) (alp-1). 10/2001 Q15648 h peroxisome proliferator- activated receptor binding protein (pbp) SW:PPRB_HUMA (ppar binding protein) (thyroid hormone R.QNSSSGSPRMEICSGSNKTKK.K 2 2.319 0.148 P N receptor-associated protein complex component trap220) (thyroid receptor i P50897 homo sapiens (human). palmitoyl-protein thioesterase precursor SW:PPT_HUMAN T.LMEDVENSFFL.N 1 2.166 0.094 A (ec 3.1.2.22) (palmitoyl- protein hydrolase). 10/2001 P78527 homo sapiens (human). dna- SW:PRKD_HUMA dependent protein kinase catalytic IPI:IPI00178328.1 R.EEESLVEQF.V 1 1.802 0.093 O N subunit (ec 2.7.1.37) (dna- pkcs) (dnpk1). (97%) 10/2001 SW:PROP_HUMA P27918 homo sapiens (human). R.CTGLPPCPVAGGWGPWGPVSPCPVTC.G 2 2.587 0.140 P N properdin precursor. 10/2001 P02812 homo sapiens (human). salivary SW:PRP2_HUMA proline-rich protein precursor (clone cp7) P.PPGKPQGPPPQGGSKSR.S 2 2.286 0.133 A, O N [contains: basic peptide p-f] (fragment). 10/2001 P47210 homo sapiens (human). 26s protease regulatory subunit 8 SW:PRS8_HUMA IPI:IPI00023919.2 (proteasome subunit p45) (thyroid L.DGPEQMELEEGKAGSGLRQYYLS.K 2 2.540 0.108 P N (93%) hormone receptor interacting protein 1) (trip1). 11/1997 P10619 homo sapiens (human). SW:PRTP_HUMA lysosomal protective protein precursor IPI:IPI00183757.1 V.LVMQDPSMNLQGLAVGNGLSSY.E 2 2.560 0.203 A N (ec 3.4.16.5) (cathepsin a) (96%) (carboxypeptidase c). 10/2001 P25787 homo sapiens (human). proteasome subunit alpha type 2 (ec 3.4.99.46) (proteasome component c3) SW:PSA2_HUMAN Y.LFQSDPSGAYFAWKATAMGKN.Y 2 2.553 0.220 A (macropain subunit c3) (multicatalytic endopeptidase complex subunit c3). 10/2001 O14818 homo sapiens (human). proteasome subunit alpha type 7 (ec SW:PSA7_HUMAN Q.SHRLTVEDPV.T 1 2.054 0.080 A 3.4.99.46) (proteasome subunit rc6-1) (proteasome subunit xapc7). 10/2001 Q16557 homo sapiens (human). SW:PSG3_HUMA pregnancy-specific beta-1-glycoprotein 3 IPI:IPI00014809.1 S.YTLHIVK.R 1 1.809 0.087 A N precursor (psbg-3) (carcinoembryonic (93%) antigen sg5). 10/2001 Q13308 homo sapiens (human). tyrosine-protein kinase-like 7 precursor IPI:IPI00168812.1 SW:PTK7_HUMAN A.SFNIKWIEAGPVVLKHPASEAE.I 2 2.662 0.169 O, P (colon carcinoma kinase-4) (cck-4). (98%) 10/2001 P26045 homo sapiens (human). protein tyrosine phosphatase, non-receptor type IPI:IPI00029624.1 SW:PTN3_HUMAN K.YICTSFYPWVNILKISFKRK.K 2 2.456 0.196 P 3 (ec 3.1.3.48) (protein-tyrosine (98%) phosphatase h1) (ptp-h1). 10/2001 Q12923 homo sapiens (human). protein SW:PTND_HUMA IPI:IPI00030246.1 tyrosine phosphatase, non-receptor type V.TNMTHTDAVNLLRAASKTVRLV.I 2 2.616 0.108 P N (96%) 13 (ec 3.1.3.48) (protein-tyrosine
Supplementary Table 2 99 phosphatase 1e) (ptp-e1) (ptp-bas) (protein-tyrosine phosphatase ptpl1) (fas Q16825 homo sapiens (human). protein tyrosine phosphatase, non-receptor type IPI:IPI00004388.1 SW:PTNL_HUMAN G.CPEDLKGFLSYLEEIQSVRR.H 2 2.239 0.138 A 21 (ec 3.1.3.48) (protein-tyrosine (94%) phosphatase d1). 10/2001 P23470 homo sapiens (human). protein- SW:PTPG_HUMA IPI:IPI00011651.1 tyrosine phosphatase gamma precursor T.GKTVAILLKDDYFVSGAGLPGRFK.A 2 2.294 0.206 O, P N (95%) (ec 3.1.3.48) (r-ptp- gamma). 10/2001 Q92729 homo sapiens (human). protein- tyrosine phosphatase u precursor (ec SW:PTPU_HUMA 3.1.3.48) (r-ptp-u) (protein-tyrosine IPI:IPI00023197.1 R.TIVHCLNGGGRSGTFCACAT.V 2 2.531 0.104 P N phosphatase j) (ptp-j) (pancreatic (98%) carcinoma phosphatase 2) (pcp-2). 10/2001 Q92932 homo sapiens (human). protein- tyrosine phosphatase x precursor (ec SW:PTPX_HUMA IPI:IPI00024289.1 3.1.3.48) (r-ptp-x) (islet cell autoantigen V.LNKMAKGAKEIDIAAT.L 1 2.227 0.186 O N (93%) related protein) (icaar) (iar) (phogrin). 10/2001 P23471 homo sapiens (human). protein- F.ELISVIKEEAANRDGPMIVHDEHGGVTAGT IPI:IPI00216283.1 SW:PTPZ_HUMAN tyrosine phosphatase zeta precursor (ec 3 3.878 0.210 G FC.A (95%) 3.1.3.48) (r-ptp- zeta). 10/2001 P31939 homo sapiens bifunctional purine biosynthesis protein purh [includes: SW:PUR9_HUMA IPI:IPI00218996.1 phosphoribosylaminoimidazolecarboxami L.PESALRDLIVATIAVKYTQ.S 2 2.401 0.125 O N (99%) de formyltransferase (ec 2.1.2.3) (aicar transformylase); imp cyclohydrola P40855 homo sapiens (human). peroxisomal farnesylated protein (33 kda SW:PXF_HUMAN P.GDTAKDALFASQEK.F 2 2.392 0.102 P housekeeping protein) (peroxin 19). 10/2001 Q02127 homo sapiens (human). SW:PYRD_HUMA dihydroorotate dehydrogenase precursor IPI:IPI00024462.1 W.RHLQKRAQDAVIILGGGGLLFAS.Y 2 2.513 0.104 P N (ec 1.3.3.1) (dihydroorotate oxidase) (97%) (fragment). 10/2001 P54727 homo sapiens (human). uv excision repair protein rad23 homolog b SW:R23B_HUMAN A.TSALVTGQSYENMVT.E 2 2.474 0.266 O (hhr23b) (xp-c repair complementing complex 58 kda protein) (p58). 10/2001 O43502 homo sapiens (human). dna IPI:IPI00012829.1 SW:R51C_HUMAN L.AVILTNQM.T 1 2.081 0.105 P repair protein rad51 homolog 3. 10/2001 (96%) P43351 homo sapiens (human). dna T.PDAGDGVVKPSSRADPAQTSDTLALNNQ SW:RA52_HUMAN 2 2.223 0.113 A repair protein rad52 homolog. 10/2001 MVTQNR.T P24407 homo sapiens (human), and SW:RAB8_HUMA canis familiaris (dog). ras-related protein N.INVENAFFTLARDIKA.K 1 2.015 0.106 P N rab-8 (oncogene c-mel). 7/1998 SW:RB2A_HUMA Q9unt1 homo sapiens (human). rab-like IPI:IPI00185360.1 V.SAADGTNVVKLFNDAIR.L 2 2.275 0.152 G N protein 2a. 10/2001 (98%) Q92804 homo sapiens (human). tata- binding protein associated factor 2n (rna- SW:RB56_HUMAN N.KKTGKPMINL.Y 2 2.457 0.118 A binding protein 56) (tafii68) (taf(ii)68). 10/2001 Q15291 homo sapiens (human). SW:RBB5_HUMA retinoblastoma-binding protein 5 (rbbp-5) IPI:IPI00021035.1 R.DGEPEPMQELQDLVNRT.P 1 1.949 0.105 A N (retinoblastoma-binding protein rbq-3). (97%) 10/2001 Q06330 homo sapiens (human). j kappa- IPI:IPI00218576.1 SW:RBJK_HUMAN recombination signal binding protein Q.ATPCPKEPNKEMINDGASWTI.I 2 2.980 0.171 O, P (97%) (rbp-j kappa). 10/2001 Q14257 homo sapiens (human). SW:RCN2_HUMA reticulocalbin 2 precursor (calcium- E.MDLNGDKKLSEEEILENPDLFLTSEATDYG IPI:IPI00029628.1 3 3.507 0.182 O N binding protein erc-55) (e6- binding R.Q (94%) protein) (e6bp). 7/1998 P25106 homo sapiens (human). g SW:RDC1_HUMA IPI:IPI00168574.1 protein-coupled receptor rdc1 homolog. V.WVVSLVQHNQWPMGE.L 1 2.153 0.123 G N (98%) 10/2001 P35243 homo sapiens (human). SW:RECO_HUMA recoverin (cancer associated retinopathy E.ILRLIQFEPQKVKEKMKNA.- 2 2.588 0.187 A N protein) (car protein). 11/1997 Q13123 homo sapiens (human). red SW:RED_HUMAN protein (rer protein) (ik factor) (cytokine A.YVVDLDDEYADTDIPTTLIRSKA.D 2 2.474 0.135 G ik). 5/2000 P22670 homo sapiens (human). mhc SW:RFX1_HUMAN class ii regulatory factor rfx1 (rfx) S.SASTGAGASNSSGGGGSGGGGGGG.G 2 3.033 0.145 A (enhancer factor c) (ef-c). 10/2001
Supplementary Table 2 100 P49798 homo sapiens (human). SW:RGS4_HUMA IPI:IPI00028112.1 regulator of g-protein signaling 4 (rgs4) K.IYNEFISVQATKEVNLDSCTR.E 2 2.225 0.125 A N (92%) (rgp4). 10/2001 P49758 homo sapiens (human). SW:RGS6_HUMA G.KVAGGQAPHGPDAVPPEPSSPQSRAWA IPI:IPI00028060.3 regulator of g-protein signaling 6 (rgs6) 2 2.303 0.139 A N RGPHR.Q (99%) (s914). 10/2001 P01121 homo sapiens (human), mus SW:RHOB_HUMA musculus (mouse), and rattus norvegicus E.TATRAALQK.R 1 1.862 0.113 A N (rat). transforming protein rhob (h6). 12/1998 O95661 homo sapiens (human). rho- IPI:IPI00032112.1 SW:RHOI_HUMAN L.LGCSHGVLSLHITDSKSGDGN.R 2 2.872 0.090 O related gtp-binding protein rhoi. 10/2001 (93%) P04843 homo sapiens (human). dolichyl- diphosphooligosaccharide--protein IPI:IPI00025874.1 SW:RIB1_HUMAN glycosyltransferase 67 kda subunit Y.LDTFGRPVIVAYKKNLVEQHIQDI.V 2 2.958 0.095 A (95%) precursor (ec 2.4.1.119) (ribophorin i) (rpn-i). 10/2001 Q15835 homo sapiens (human). IPI:IPI00019980.1 SW:RK_HUMAN rhodopsin kinase (ec 2.7.1.125) (rk). A.LGVTLYEMIAARGPFR.A 1 1.982 0.142 O (92%) 10/2001 P38663 homo sapiens (human), rattus SW:RL24_HUMAN norvegicus (rat), and bos taurus (bovine). K.FQRAITGASLADIMAKR.N 2 2.211 0.126 G 60s ribosomal protein l24 (l30). 10/2001 P02433 homo sapiens (human), mus IPI:IPI00219159.1 SW:RL32_HUMAN musculus (mouse), and rattus norvegicus R.FKGQILMPNIGYGSNK.K 2 2.268 0.114 P (91%) (rat). 60s ribosomal protein l32. 10/2001 P11518 homo sapiens (human), and rattus norvegicus (rat). 60s ribosomal IPI:IPI00093565.3 SW:RL7A_HUMAN L.LARAEKKAAGKGDVPTKRPPVLR.A 2 2.385 0.143 P protein l7a (surfeit locus protein 3) (pla-x (97%) polypeptide). 10/2001 Q9nvw2 homo sapiens (human). ring finger protein 12 (lim domain interacting SW:RN12_HUMAN ring finger protein) (ring finger lim E.NRGGDSSDDVSNGDSIIDWLNSVR.Q 2 2.466 0.152 P domain-binding protein) (r-lim) (ny-ren-43 antigen). 10/2001 Q9bzr9 homo sapiens (human). ring finger protein 27 (glioblastoma- IPI:IPI00221086.1 SW:RN27_HUMAN A.QALHLGERMQEAKK.L 1 2.176 0.083 G expressed ring finger protein) (tripartite (99%) motif protein 8). 10/2001 P14866 homo sapiens (human). SW:ROL_HUMAN heterogeneous nuclear ribonucleoprotein F.VNYSTSQKISR.P 1 2.058 0.082 G l (hnrnp l). 10/2001 Q01973 homo sapiens (human). tyrosine-protein kinase transmembrane SW:ROR1_HUMA IPI:IPI00010405.1 receptor ror1 precursor (ec 2.7.1.112) L.AARNILIGEQLHVKISDLGLSR.E 2 2.675 0.092 A N (95%) (neurotrophic tyrosine kinase, receptor- related 1). 10/2001 Q00839 homo sapiens (human). heterogenous nuclear ribonucleoprotein SW:ROU_HUMAN R.GGGGGGSGGIGYPYPRAPVFPGR.G 2 2.272 0.119 G u (hnrnp u) (scaffold attachment factor a) (saf-a). 10/2001 P30876 homo sapiens (human). dna- SW:RPB2_HUMA directed rna polymerase ii 140 kda IPI:IPI00217215.1 I.GPTYYQRLKHMVDDKI.H 1 2.196 0.132 A N polypeptide (ec 2.7.7.6) (rna polymerase (97%) ii subunit 2) (rpb2). 10/2001 Q92834 homo sapiens (human). x-linked SW:RPGR_HUMA IPI:IPI00023757.2 retinitis pigmentosa gtpase regulator. L.KNVSNVCVPQ.Q 2 2.633 0.085 G N (93%) 10/2001 SW:RRAS_HUMA P10301 homo sapiens (human). ras- R.EQYMRAGHGFLLVFAINDRQSFNEVGKLF 3 3.526 0.092 O N related protein r-ras (p23). 11/1997 .T Q02546 homo sapiens (human), rattus SW:RS13_HUMAN norvegicus (rat), and sus scrofa (pig). E.RNRKDKDAKFR.L 2 2.266 0.108 A 40s ribosomal protein s13. 10/2001 P06366 homo sapiens (human), and cricetulus griseus (chinese hamster). 40s SW:RS14_HUMAN I.SLGPQVAEGENVF.G 2 2.668 0.251 O ribosomal protein s14 (protein pro2640). 10/2001 SW:RSG5_HUMA O43374 homo sapiens (human). rasgap- IPI:IPI00012059.1 V.KKSCYPRWNETFEFELQEGAMEALC.V 2 2.418 0.171 A N activating-like protein 2. 10/2001 (97%) O00442 homo sapiens (human). rna 3'- SW:RTC1_HUMA terminal phosphate cyclase (ec 6.5.1.4) IPI:IPI00186847.1 I.YGRAFVAGVLP.F 1 2.214 0.162 A N (rna-3'-phosphate cyclase) (rna cyclase). (97%) 10/2001 Q16799 homo sapiens (human). SW:RTN1_HUMA reticulon 1 (neuroendocrine-specific F.SVVSVVAYLALAALSATISFR.I 2 2.211 0.118 G N protein). 10/2001
Supplementary Table 2 101 Q92545 homo sapiens (human). rw1 SW:RW1_HUMAN T.GFMEGLSRHLILNLIL.K 2 2.681 0.092 G, O protein (fragment). 10/2001 SW:RXRG_HUMA P48443 homo sapiens (human). retinoic S.QLNVVNSVSSSEDIK.P 1 1.959 0.106 P N acid receptor rxr-gamma. 10/2001 P06702 homo sapiens (human). calgranulin b (migration inhibitory factor- SW:S109_HUMAN related protein 14) (mrp-14) (p14) K.LGHPDTLNQGEFK.E 2 2.499 0.155 P (leukocyte l1 complex heavy chain) (s100 calcium- binding protein a9). 10/2001 P48594 homo sapiens (human). SW:SCC2_HUMA IPI:IPI00010303.1 squamous cell carcinoma antigen 2 D.LKDTLRTMGMVNIFNGDADLSGMTW.S 2 2.414 0.184 A N (91%) (scca-2) (leupin). 10/2001 P34741 homo sapiens (human). SW:SDC2_HUMA syndecan-2 precursor (fibroglycan) R.KPSSAAYQKAPTK.E 2 2.204 0.156 A N (heparan sulfate proteoglycan core protein) (hspg) (synd2). 10/2001 O60613 homo sapiens (human). 15 kda IPI:IPI00030877.1 SW:SE15_HUMAN F.GLRLLLATVLQAVSAFG.A 1 2.048 0.110 O selenoprotein precursor. 10/2001 (92%) P17257 homo sapiens (human). sec SW:SEC_HUMAN A.RRFTSADSRLGCLLQYLGER.R 2 2.429 0.170 O protein. 10/2001 SW:SEGN_HUMA O76038 homo sapiens (human). IPI:IPI00008730.2 I.FAYYDVSKTGALEGPEVDGFVKD.M 2 2.406 0.104 O N secretagogin. 10/2001 (99%) SW:SELN_HUMA Q9nzv5 homo sapiens (human). IPI:IPI00021574.1 F.APQGAVACLTAISDFYYTVMFRI.H 2 2.585 0.169 P N selenoprotein n precursor. 10/2001 (94%) Q16181 homo sapiens (human). septin 7 IPI:IPI00033025.1 SW:SEP7_HUMAN H.EQMKKNLEAQHKELEEKR.R 2 2.492 0.153 O (cdc10 protein homolog). 10/2001 (94%) I.DSKFEDYLNAE.S 2 2.688 0.231 O43556 homo sapiens (human). epsilon- SW:SGCE_HUMA IPI:IPI00012881.1 sarcoglycan precursor (epsilon-sg). V.STYQEVIRGEGILPDGGEYKPPSDSLK.S 3 3.552 0.092 A N (97%) 10/2001 Q13326 homo sapiens (human). gamma- SW:SGCG_HUMA sarcoglycan (gamma-sg) (35 kda IPI:IPI00218559.1 C.LPKLVQGTWGPS.G 2 3.241 0.211 G, O, P N dystrophin-associated glycoprotein) (93%) (35dag). 10/2001 O00141 homo sapiens (human). serine/threonine-protein kinase sgk (ec IPI:IPI00010391.1 SW:SGK_HUMAN L.INKKITPPFNPNVSGPNELRH.F 2 2.665 0.081 P 2.7.1.-) (serum/glucocorticoid-regulated (94%) kinase). 10/2001 O60902 homo sapiens (human). short SW:SHX2_HUMA stature homeobox protein 2 (paired- G.GGGGVGGGGAGGGAGGGRSPVR.E 1 2.249 0.181 P N related homeobox protein shot) (homeobox protein og12x). 10/2001 Q15477 homo sapiens (human). helicase L.VKVLFATETFAMGVNMPARTVVFDSMRKH IPI:IPI00178098.1 SW:SKIW_HUMAN ski2w (helicase-like protein) (hlp). 3 3.799 0.187 P .D (94%) 10/2001 P53794 homo sapiens (human). sodium/myo-inositol cotransporter IPI:IPI00023578.1 SW:SL53_HUMAN W.YWCADQVIVQRVLAAKNIAH.A 2 2.413 0.117 P (na(+)/myo-inositol cotransporter). (96%) 10/2001 O95754 homo sapiens (human). SW:SM4F_HUMA IPI:IPI00216574.1 semaphorin 4f precursor (semaphorin w) G.AYACECQEGGAAHVVAAY.S 1 2.120 0.090 A N (98%) (sema w). 10/2001 SW:SM4G_HUMA Q9ntn9 homo sapiens (human). R.ALWLLNGSMGLSDGQGGYR.V 2 2.311 0.142 P N semaphorin 4g precursor. 10/2001 Q9bzz2 homo sapiens (human). sialoadhesin precursor (sialic acid IPI:IPI00219698.1 SW:SN_HUMAN R.LLHGDRLVASTLQGVGGPEGSSPR.L 2 2.279 0.299 A binding ig-like lectin-1) (siglec- 1) (cd169 (96%) antigen). 10/2001 P57059 homo sapiens (human). SW:SN1L_HUMAN probable serine/threonine protein kinase Q.ENEARK.K 1 1.810 0.086 P snf1lk (ec 2.7.1.-). 10/2001 P51531 homo sapiens (human). possible SW:SN22_HUMAN global transcription activator snf2l2 (snf2- L.PETLQLAVQ.G 1 2.245 0.085 O alpha). 10/2001 SW:SNX7_HUMA Q9unh6 homo sapiens (human). sorting E.RFNDDFIETRR.K 1 1.834 0.087 O N nexin 7. 10/2001 SW:SNXD_HUMA Q9y5w8 homo sapiens (human). sorting IPI:IPI00001866.3 E.RFYPSFRQNALYV.R 2 2.466 0.188 A N nexin 13 (fragment). 10/2001 (94%) Q92543 homo sapiens (human). sorting SW:SNXJ_HUMAN S.CVSDAAVPAQDPSNSD.P 2 3.127 0.162 P nexin 19. 10/2001 O75908 homo sapiens (human). sterol o- acyltransferase 2 (ec 2.3.1.26) SW:SOA2_HUMA IPI:IPI00102769.1 (cholesterol acyltransferase 2) (acyl Q.APSFSSYLYFLFCPTLIYRETYPR.T 2 2.598 0.134 A N (91%) coenzyme a:cholesterol acyltransferase 2) (acat-2). 10/2001 SW:SORL_HUMA Q92673 h sortilin-related receptor E.NDCGDWSDEKDCGDSHI.L 2 2.699 0.081 P IPI:IPI00022608.1
Supplementary Table 2 102 N precursor (sorting protein-related (97%) receptor containing ldlr class a repeats) (sorla) (sorla-1) (low-density lipoprotein receptor relative with 11 ligand- Q07890 homo sapiens (human). son of SW:SOS2_HUMA IPI:IPI00176886.1 sevenless protein homolog 2 (sos-2). R.DISTCPNSPSTPPST.P 1 1.925 0.091 G N (95%) 10/2001 SW:SOX9_HUMA P48436 homo sapiens (human). K.ESEEDKFPVCIREAVSQVLKGYDWTLVPM 3 3.575 0.144 A N transcription factor sox-9. 10/2001 PVRVNGSSKNKPH.V Q15005 homo sapiens (human). SW:SPC1_HUMA IPI:IPI00220125.1 microsomal signal peptidase 25 kda S.LDDSAKKVLLEKYKY.V 1 2.094 0.092 A N (97%) subunit (ec 3.4.-.-) (spc25). 10/2001 Q13813 homo sapiens (human). spectrin SW:SPCN_HUMA alpha chain, brain (spectrin, non- L.LTKQETFDAGLQAFQQEGIANITALKDQLL IPI:IPI00015786.1 3 3.608 0.133 O N erythroid alpha chain) (fodrin alpha AAKHVQSK.A (97%) chain). 10/2001 Q92797 homo sapiens (human). IPI:IPI00181585.1 SW:SPK_HUMAN T.EAALLDSSLEGPLPK.E 2 2.327 0.210 G symplekin. 10/2001 (95%) O95104 homo sapiens (human). ctd- SW:SRA4_HUMA binding sr-like protein ra4 (fragment). A.AAVPPAPTATVPAAAAPAAASPPPPQAP.F 2 2.917 0.134 P N 10/2001 P08240 homo sapiens (human). signal SW:SRPR_HUMA recognition particle receptor alpha IPI:IPI00178135.1 V.LIAACDTFRAGAVEQLRTHTR.R 2 2.388 0.202 G N subunit (sr-alpha) (docking protein alpha) (92%) (dp-alpha). 2/1996 P30872 homo sapiens (human). SW:SSR1_HUMA somatostatin receptor type 1 (ss1r) (srif- T.ASSPSSSPSPSPGSCGEGGGSR.G 2 2.341 0.150 A N 2). 10/2001 Q15531 homo sapiens (human). syntaxin IPI:IPI00018067.1 SW:ST1B_HUMAN V.KKQHSAILAAPNPDERTKQELE.D 2 2.724 0.103 G 1b. 10/2001 (95%) P42224 homo sapiens (human). signal transducer and activator of transcription IPI:IPI00218188.1 SW:STA1_HUMAN L.PLWNDGCIMGFISKERERALLK.D 2 2.206 0.131 O 1-alpha/beta (transcription factor isgf-3 (98%) components p91/p84). 10/2001 P40763 homo sapiens (human). signal IPI:IPI00181144.1 SW:STA3_HUMAN transducer and activator of transcription W.EESRLLQTAATAAQQGGQAN.H 2 2.494 0.128 P (97%) 3 (acute-phase response factor). 11/1997 Q9unk0 homo sapiens (human). syntaxin SW:STX8_HUMAN D.EKLRNETRRVNMVDR.K 2 2.235 0.189 A 8. 10/2001 SW:SUR1_HUMA Q15526 homo sapiens (human). surfeit IPI:IPI00018034.1 W.RPSRCGSSAAEASATK.A 2 2.387 0.166 A N locus protein 1. 5/2000 (94%) Q9gzr1 homo sapiens (human). sumo-1- SW:SUS1_HUMA specific protease 1 (ec 3.4.22.-) (sentrin- IPI:IPI00179878.1 Y.LKYLVLEKLKKEDADR.I 2 2.373 0.112 A N specific protease senp6) (protease (91%) fksg6). 10/2001 P56693 homo sapiens (human). SW:SX10_HUMAN P.QSHSPTHWEQPVYTTL.S 1 2.094 0.152 G transcription factor sox-10. 10/2001 Q9y651 homo sapiens (human). sox-21 IPI:IPI00028830.1 SW:SX21_HUMAN E.HPALKAGAGLHAGAGGGLVPESL.L 2 2.766 0.105 G protein. 10/2001 (98%) O00585 homo sapiens (human). small inducible cytokine a21 precursor (beta SW:SY21_HUMAN chemokine exodus-2) (6ckine) Q.LMQHLDKTPSPQK.P 2 2.514 0.149 A (secondary lymphoid-tissue chemokine) (slc). 5/2000 SW:SYN3_HUMA O14994 homo sapiens (human). IPI:IPI00024812.1 W.VFSQLIKIFHSL.G 2 2.523 0.105 G N synapsin iii. 10/2001 (92%) Q9h2b2 homo sapiens (human). K.THVKKCTPNAVFNELFVFDIPCEGLEDISV IPI:IPI00022735.1 SW:SYT4_HUMAN 3 3.659 0.152 P synaptotagmin iv (sytiv). 10/2001 EFLVLDS.E (94%) P26640 homo sapiens (human). valyl- SW:SYV2_HUMAN trna synthetase 2 (ec 6.1.1.9) (valine-- P.LDVIYGISLQGLHNQLLNSNLDPSEVEK.A 3 3.520 0.128 P trna ligase 2) (valrs 2). 10/2001 O14625 homo sapiens (human). small inducible cytokine b11 precursor (interferon-inducible t-cell alpha SW:SZ11_HUMAN E.KASIMYPSNNCDKIEVIITL.K 2 2.405 0.146 O chemoattractant) (i-tac) (interferon- gamma-inducible protein-9) (ip-9) (h174) (beta-r Q9ubn6 homo sapiens tumor necrosis factor receptor superfamily member 10d IPI:IPI00021969.1 SW:T10D_HUMAN precursor (decoy receptor 2) (dcr2) (tnf- G.SHRSEYTGACNPCTEGVDY.T 2 2.467 0.111 P (95%) related apoptosis-inducing ligand receptor 4) (trail receptor-4) (trail-r O14981 homo sapiens (human). tbp- IPI:IPI00024802.1 SW:T172_HUMAN associated factor 172 (taf-172) K.MGDSTLEEM.I 1 2.000 0.094 G (95%) (taf(ii)170). 10/2001 SW:T2D3_HUMAN O00268 homo sapiens (human). A.AQTASLGTATAVQTGTPQRTVPG.A 2 2.603 0.186 G
Supplementary Table 2 103 transcription initiation factor tfiid 135 kda subunit (tafii-135) (tafii135) (tafii-130) (tafii130). 10/2001 Q12962 homo sapiens (human). SW:T2D8_HUMAN transcription initiation factor tfiid 30 kda A.RAGEPAERRGAAPVSAGGAAPPEGAI.S 2 2.437 0.206 A subunit (tafii-30) (tafii30). 10/2001 Q92750 homo sapiens (human). transcription initiation factor tfiid 105 kda SW:T2DT_HUMAN V.TLSLPAVTFGETSGAAICLPSVK.P 2 2.209 0.157 A subunit (tafii-105) (tafii105) (fragment). 10/2001 P29084 homo sapiens (human). IPI:IPI00019981.1 SW:T2EB_HUMAN transcription initiation factor iie, beta N.NPKIEVIDGKYAFKPKYNV.R 2 2.688 0.104 G (93%) subunit (tfiie-beta). 10/2001 P19075 homo sapiens (human). transmembrane 4 superfamily, member 3 IPI:IPI00015872.1 SW:T4S3_HUMAN I.IVFQEEFKCCGLVNGAADWGN.N 2 2.489 0.118 G (tumor-associated antigen co- 029). (94%) 10/2001 Q03518 homo sapiens (human). antigen peptide transporter 1 (apt1) (peptide SW:TAP1_HUMAN transporter tap1) (peptide transporter L.AKSSQVAIEALSAMP.T 1 2.140 0.120 G psf1) (peptide supply factor 1) (psf-1) (peptide transporter involved in a Q03519 homo sapiens (human). antigen peptide transporter 2 (apt2) (peptide IPI:IPI00218827.1 SW:TAP2_HUMAN transporter tap2) (peptide transporter T.GGQVLLDEKPISQY.E 2 2.571 0.103 A (91%) psf2) (peptide supply factor 2) (psf-2) (peptide transporter involved in a Q13207 homo sapiens (human). t-box SW:TBX2_HUMAN transcription factor tbx2 (t-box protein 2). P.YTYMAAAAAAASALPATSAAAAAAAA.A 2 2.485 0.192 A 10/2001 P37275 homo sapiens (human). transcription factor 8 (nil-2-a zinc finger SW:TCF8_HUMAN M.TNSPVLPVGSTTNGSRSSTPSPSPLNL.S 2 2.428 0.107 P protein) (negative regulator of il2). 10/2001 P20062 homo sapiens (human). SW:TCO2_HUMA IPI:IPI00219465.1 transcobalamin ii precursor (tcii) (tc ii). A.MAGLAFTCLKRSNFNPGRR.Q 2 2.272 0.257 P N (96%) 10/2001 P50991 homo sapiens (human). t- SW:TCPD_HUMA complex protein 1, delta subunit (tcp-1- IPI:IPI00220345.1 D.GKGDVTITNDGA.T 1 2.095 0.088 O N delta) (cct-delta) (stimulator of tar rna (97%) binding). 10/2001 P49368 homo sapiens (human). t- SW:TCPG_HUMA IPI:IPI00026830.2 complex protein 1, gamma subunit (tcp- I.DIKKYARVEKIPGGIIEDSCV.L 2 2.435 0.102 G N (99%) 1-gamma) (cct-gamma). 12/1998 P40227 homo sapiens (human). t- SW:TCPZ_HUMA complex protein 1, zeta subunit (tcp-1- IPI:IPI00027626.1 I.AKVATAQDDITGDGTTSNVLIIG.E 2 2.518 0.210 G N zeta) (cct-zeta) (cct-zeta-1) (tcp20) (htr3). (95%) 10/2001 O75949 homo sapiens (human). ted SW:TED_HUMAN S.NQGGGGLGLETLPAL.E 2 2.484 0.149 O protein. 10/2001 Q13888 homo sapiens (human). tfiih basal transcription factor complex p44 IPI:IPI00015281.2 SW:TFH2_HUMAN subunit (basic transcription factor 2 44 S.DILFK.I 1 1.825 1.000 P (95%) kda subunit) (btf2-p44) (general transcription factor iih polypeptide 2). P21980 homo sapiens (human). protein- SW:TGLC_HUMA glutamine gamma-glutamyltransferase IPI:IPI00011294.2 L.CILYEKYR.D 1 2.103 0.100 O N (ec 2.3.2.13) (tissue transglutaminase) (97%) (tgase c) (tgc) (tgase-h). 10/2001 O95411 homo sapiens (human). tgfb1- induced anti-apoptotic factor 1 (12 kda N.PFQLQQFRADPSTASLLLCPGGLDHKLNL SW:TIAF_HUMAN 3 3.544 0.156 P tgf-beta1-induced antiapoptotic factor). R.G 10/2001 P29401 homo sapiens (human). IPI:IPI00186039.1 SW:TKT_HUMAN Y.AVWAEAGFLAEAELL.N 2 2.666 0.204 O transketolase (ec 2.2.1.1) (tk). 10/2001 (96%) P49755 homo sapiens (human). transmembrane protein tmp21 precursor SW:TM21_HUMAN (21 kda transmembrane trafficking Y.EEIAKVEKLKPLEVELRRLEDLSESIVND.F 3 3.966 0.191 G protein) (p24delta) (s31iii125) (s31i125) (tmp-21-i). 10/2001 O15393 homo sapiens (human). SW:TMS2_HUMA IPI:IPI00006212.2 transmembrane protease, serine 2 S.FMKLNTSAGNVDIYKKL.Y 2 2.701 0.142 O N (96%) precursor (ec 3.4.21.-). 10/2001 P57727 homo sapiens (human). SW:TMS3_HUMA transmembrane protease, serine 3 (ec IPI:IPI00027977.1 V.LNHAAVPLISNK.I 1 2.008 0.085 P N 3.4.21.-) (serine protease tadg-12) (93%) (tumor associated differentially- Supplementary Table 2 104 expressed gene-12 protein). 10/2001 Q9nrs4 homo sapiens (human). SW:TMS4_HUMA transmembrane protease, serine 4 (ec IPI:IPI00221211.1 F.NWKVRAGSDKLGSF.P 2 2.443 0.210 G, O N 3.4.21.-) (membrane-type serine (94%) protease 2) (mt-sp2). 10/2001 O95859 homo sapiens (human). IPI:IPI00000737.1 SW:TNE2_HUMAN V.WTYEQELMVPVQW.S 2 2.599 0.128 P tetraspan net-2. 10/2001 (96%) P32970 homo sapiens (human). cd27 IPI:IPI00031713.2 SW:TNF7_HUMAN P.TTLAVGICSPASRSISLLRLSF.H 2 2.485 0.227 O ligand (cd27-l) (cd70 antigen). 10/2001 (99%) SW:TNG1_HUMA P56846 homo sapiens (human). tng1 C.FKLSLPAKF.P 1 2.289 0.143 A N protein. 5/2000 SW:TOB1_HUMA P50616 homo sapiens (human). tob1 A.FDVFAAYGGLN.E 1 2.335 0.212 A N protein (transducer of erbb-2 1). 10/2001 O95985 homo sapiens (human). dna IPI:IPI00216816.1 SW:TP3B_HUMAN topoisomerase iii beta-1 (ec 5.99.1.2). K.VDPAELFSQAPTEK.K 2 2.487 0.102 O (99%) 10/2001 P07951 homo sapiens (human). SW:TPMB_HUMA tropomyosin beta chain, skeletal muscle E.AQADKYSTKEDK.Y 2 2.545 0.111 A N (tropomyosin 2, skeletal muscle). 10/2001 Q93038 h wsl-1 protein precursor (apoptosis-mediating receptor dr3) IPI:IPI00185110.1 SW:TR12_HUMAN (apoptosis- mediating receptor tramp) G.CAAVAAAL.L 1 2.160 0.082 A (93%) (death domain receptor 3) (wsl protein) (apoptosis inducing receptor air) (apo-3) Q13114 homo sapiens (human). tnf receptor associated factor 3 (cd40 receptor associated factor 1) (craf1) SW:TRA3_HUMAN D.IRLADMDLR.F 1 1.953 0.101 P (cd40 binding protein) (cd40bp) (lmp1 associated protein) (lap1) (cap-1). 10/2001 Q12931 homo sapiens (human). tumor SW:TRAL_HUMAN necrosis factor type 1 receptor F.FIDQSKKDAEK.Y 1 2.279 0.091 G associated protein (trap-1). 10/2001 SW:TRHY_HUMA Q07283 homo sapiens (human). R.FLPEEEEKEQRGRQRRER.E 2 2.207 0.164 O N trichohyalin. 10/2001 O75962 homo sapiens (human). triple IPI:IPI00026676.1 SW:TRIO_HUMAN functional domain protein (ptprf P.EQQVKNILNELFQR.E 2 2.293 0.132 G (96%) interacting protein). 10/2001 V.RHHPPVLVSSAASSQAEADKMSGTSTPG. 2 2.479 0.124 P O75648 homo sapiens (human). SW:TRMU_HUMA probable trna (5-methylaminomethyl-2- L.REPWYVVEKDSVK.G 2 2.416 0.125 P N thiouridylate)-methyltransferase (ec 2.1.1.61). 5/2000 Q9ubn4 homo sapiens (human). short transient receptor potential channel 4 IPI:IPI00219494.1 SW:TRP4_HUMAN V.MNSLYLATISLKIVAFVKYSALN.P 2 2.669 0.149 A (trpc4) (trp-related protein 4) (htrp-4) (99%) (htrp4). 10/2001 Q9umn6 homo sapiens (human). trithorax homolog 2 (mixed lineage SW:TRX2_HUMAN S.SPTSRYIHF.P 1 2.092 0.085 A leukemia gene homolog 2 protein). 10/2001 P49815 homo sapiens (human). tuberin IPI:IPI00028493.1 SW:TSC2_HUMAN A.DQRPESSLLNLISYRAQSIHPAK.D 2 2.337 0.132 G (tuberous sclerosis 2 protein). 10/2001 (93%) P07996 homo sapiens (human). IPI:IPI00014046.1 SW:TSP1_HUMAN K.GTSQNDPNWVVR.H 2 2.299 0.137 G thrombospondin 1 precursor. 10/2001 (93%) P04436 homo sapiens (human). t-cell SW:TVA1_HUMAN receptor alpha chain v region hpb-mlt K.STSSFNFTITAS.Q 1 2.046 0.093 P precursor (fragment). 10/2001 P07101 homo sapiens (human). tyrosine IPI:IPI00218277.1 SW:TY3H_HUMAN 3-monooxygenase (ec 1.14.16.2) A.KQAEAIMVRGQGAPGPSLTG.S 2 2.417 0.220 O (95%) (tyrosine 3-hydroxylase) (th). 5/2000 P01253 homo sapiens (human), bos taurus (bovine), rattus norvegicus (rat), SW:TYB4_HUMAN and equus caballus (horse). thymosin K.TETQEKNPLPSKETIEQEKQAGES.- 3 3.546 0.195 O beta-4 (fx) [contains: hematopoietic system regulatory peptide]. 10/2001 Q06418 homo sapiens (human). tyrosine-protein kinase receptor tyro3 SW:TYO3_HUMA IPI:IPI00030887.1 precursor (ec 2.7.1.112) (tyrosine-protein V.ERSDAGRYWCQVEDGGETEIS.Q 2 2.679 0.167 A N (94%) kinase rse) (tyrosine-protein kinase sky) (tyrosine- protein kinase dtk) (pro P49459 homo sapiens (human). SW:UBCA_HUMA IPI:IPI00012060.1 ubiquitin-conjugating enzyme e2-17 kda Y.ADGSICLDILQ.N 2 2.424 0.126 A N (95%) (ec 6.3.2.19) (ubiquitin-protein ligase)
Supplementary Table 2 105 (ubiquitin carrier protein) (hr6a). 10/2001 P50550 homo sapiens (human), mus musculus (mouse), and xenopus laevis SW:UBCI_HUMAN (african clawed frog). ubiquitin-like F.KLRMLFKDDYPSSPPKC.K 2 2.503 0.189 G protein sumo-1 conjugating enzyme (ec 6.3.2.19) (sumo-1-protein ligase) (ubiquit Q9y5k5 homo sapiens (human). ubiquitin carboxyl-terminal hydrolase isozyme l5 IPI:IPI00219512.1 SW:UBL5_HUMAN (ec 3.4.19.12) (uch- l5) (ubiquitin F.IFFAK.P 1 1.901 0.101 A (99%) thiolesterase l5) (ubiquitin c-terminal hydrolase uch37) (cgi-70) (ad-019) Q9uk80 homo sapiens (human). ubiquitin carboxyl-terminal hydrolase 23 (ec SW:UBPN_HUMA IPI:IPI00017645.1 3.1.2.15) (ubiquitin thiolesterase 23) L.ELGRGRTSGPRPRGPLRA.D 2 2.432 0.142 O N (99%) (ubiquitin-specific processing protease 23) (deubiquitinating enzyme 23) (n Q9uhp3 homo sapiens (human). ubiquitin carboxyl-terminal hydrolase 25 (ec SW:UBPP_HUMA IPI:IPI00059779.1 3.1.2.15) (ubiquitin thiolesterase 25) E.KLSVLESCLHRWRTEI.E 1 2.014 0.081 G N (95%) (ubiquitin-specific processing protease 25) (deubiquitinating enzyme 25) (u Q9bxu7 homo sapiens (human). ubiquitin carboxyl-terminal hydrolase 26 (ec SW:UBPQ_HUMA IPI:IPI00011092.1 3.1.2.15) (ubiquitin thiolesterase 26) I.CEQAPQQALPQSFPKPGTQ.G 2 2.517 0.152 O N (96%) (ubiquitin-specific processing protease 26) (deubiquitinating enzyme 26). 1 P25874 homo sapiens (human). SW:UCP1_HUMA mitochondrial brown fat uncoupling A.DVITFPLDTAKVRLQVQGEC.P 2 2.564 0.273 A N protein 1 (ucp 1) (thermogenin). 10/2001 P22309 homo sapiens (human). udp- glucuronosyltransferase 1-1 precursor, IPI:IPI00026106.1 SW:UD11_HUMAN microsomal (ec 2.4.1.17) (udpgt) (ugt-1a) I.MRLSSLHKDR.P 2 2.234 0.108 G (96%) (ugt1*1) (ugt1-01) (ugt1.1) (ugt1a1) (bilirubin specific isozyme 1) (ugt1a P35504 homo sapiens (human). udp- glucuronosyltransferase 1-5 precursor, IPI:IPI00019308.1 SW:UD15_HUMAN microsomal (ec 2.4.1.17) (udpgt) (ugt-1e) T.SFDVVLTDPFHLCAAVL.A 2 2.726 0.226 P (97%) (ugt1*5) (ugt1-05) (ugt1.5) (ugt1a5) (ugt1e). 10/2001 P36537 homo sapiens (human). udp- SW:UDBA_HUMA glucuronosyltransferase 2b10 precursor, IPI:IPI00151500.4 K.HLRVAAHNLTWFQYHS.L 1 1.842 0.128 G N microsomal (ec 2.4.1.17) (udpgt). (95%) 10/2001 P30530 homo sapiens (human). tyrosine- L.YVNMDEGGGYPEPPGAAGGADPPTQPDP IPI:IPI00166871.1 SW:UFO_HUMAN protein kinase receptor ufo precursor (ec 2 2.543 0.110 A KDSCSC.L (93%) 2.7.1.112) (axl oncogene). 10/2001 P15313 homo sapiens (human). vacuolar atp synthase subunit b, kidney isoform (ec 3.6.1.34) (v- atpase b1 subunit) SW:VAB1_HUMAN Y.AEALREVSAAREEVPGRRGF.P 2 2.460 0.129 P (vacuolar proton pump b isoform 1) (endomembrane proton pump 58 kda subuni Q15904 homo sapiens (human). vacuolar atp synthase subunit s1 SW:VAS1_HUMAN precursor (ec 3.6.1.34) (v-atpase s1 L.NASLPAL.L 1 2.029 0.100 A subunit) (v-atpase s1 accessory protein) (v-atpase ac45 subunit) (xap-3). 10/2001 Q9y5k8 homo sapiens (human). vacuolar atp synthase subunit d (ec 3.6.1.34) (v- SW:VATD_HUMA IPI:IPI00004250.2 atpase d subunit) (vacuolar proton pump A.KFTAGDFSTTVIQNVNKAQ.V 2 2.518 0.117 G N (97%) d subunit) (v-atpase 28 kda accessory protein). 10/2001 P27449 homo sapiens (human). vacuolar SW:VATL_HUMAN atp synthase 16 kda proteolipid subunit F.LQLGAGLSVGLSGL.A 1 2.033 0.129 G (ec 3.6.1.34). 10/2001 P15498 homo sapiens (human). vav IPI:IPI00011696.1 SW:VAV_HUMAN A.EFAISIKYNVEVKHIK.I 1 1.857 0.136 G proto-oncogene. 10/2001 (97%) P19320 homo sapiens (human). vascular SW:VCA1_HUMA cell adhesion protein 1 precursor (v-cam I.AMRMEDSGIYVCEGV.N 2 2.531 0.112 O, P N 1) (cd106 antigen) (incam-100). 10/2001 P11473 homo sapiens (human). vitamin SW:VDR_HUMAN d3 receptor (vdr) (1,25-dihydroxyvitamin K.ALFTCPFNGDCRITKDNRR.H 2 2.256 0.187 P d3 receptor). 10/2001 Q00341 homo sapiens (human). vigilin SW:VGLN_HUMA IPI:IPI00022228.1 (high density lipoprotein-binding protein) K.SQHKYVIGPK.G 2 2.280 0.340 P N (95%) (hdl-binding protein). 10/2001
Supplementary Table 2 106 P38435 homo sapiens (human). vitamin SW:VKGC_HUMA k-dependent gamma-carboxylase (ec L.DLSAGFLLFF.D 1 2.047 0.086 O N 6.4.-.-) (gamma-glutamyl carboxylase). 10/2001 O75436 homo sapiens (human). vps26 IPI:IPI00220055.1 SW:VP26_HUMAN P.TMRDVNKKFSVRYFLNLVL.V 2 2.676 0.167 O protein homolog. 10/2001 (99%) SW:WDR6_HUMA Q9nnw5 homo sapiens (human). wd- IPI:IPI00013953.1 L.LEDKHFQSYCLLE.A 1 2.266 0.081 G N repeat protein 6. 10/2001 (96%) SW:WDR8_HUMA Q9p2s5 homo sapiens (human). wd- IPI:IPI00180232.1 A.EKSPQLGLGCLSFPPPRAGAGPL.P 2 2.469 0.127 P N repeat protein 8. 10/2001 (91%) Q14191 homo sapiens (human). werner IPI:IPI00029107.1 SW:WRN_HUMAN I.CSSSKRSKEEVGINTETSSAER.K 2 2.285 0.141 O syndrome helicase. 10/2001 (96%) P28715 homo sapiens (human). dna- repair protein complementing xp-g cells SW:XPG_HUMAN (xeroderma pigmentosum group g C.VTAMEILNEFPGHGLE.P 2 3.208 0.118 O complementing protein) (dna excision repair protein ercc-5). 10/2001 SW:XRP2_HUMA O75695 homo sapiens (human). xrp2 F.FLVQTKEVSMKAEDAQ.R 2 2.662 0.144 A N protein. 10/2001 Q14699 homo sapiens (human). IPI:IPI00177563.1 SW:Y084_HUMAN hypothetical protein kiaa0084 (ha2022) M.SDHFRKGGMLVNAVFYL.G 1 2.353 0.083 A (93%) (fragment). 10/2001 Q14695 homo sapiens (human). SW:Y087_HUMAN hypothetical protein kiaa0087 (ha1002). N.LATSLPTAASLGLGK.G 1 2.149 0.083 G 10/2001 P42696 homo sapiens (human). SW:Y117_HUMAN hypothetical protein kiaa0117 (hal845) N.LPVTCNKKKLKSFFKEYGQIE.S 2 3.126 0.170 A (fragment). 10/2001 Q14139 homo sapiens (human). IPI:IPI00028957.1 SW:Y126_HUMAN V.SMAVLLVQLAIGNEGSQPIELTFPLPDG.Y 2 2.438 0.157 A hypothetical protein kiaa0126. 11/1997 (97%) Q14140 homo sapiens (human). SW:Y127_HUMAN H.EDGLEGKIVSPCDGPSKVSYTLQR.Q 2 2.247 0.155 P hypothetical protein kiaa0127. 10/2001 Q14157 homo sapiens (human). SW:Y144_HUMAN K.APPNLPPGVPPLLPNPYIMAPGLLHA.Y 2 2.442 0.170 A hypothetical protein kiaa0144. 10/2001 K.YPPPYK.H 1 1.805 0.090 Q14166 homo sapiens (human). IPI:IPI00029048.2 SW:Y153_HUMAN hypothetical protein kiaa0153 (fragment). R.AMYAVDLMLKWDNGPDGR.R 2 2.216 0.112 G (97%) 10/2001 Q14693 homo sapiens (human). SW:Y188_HUMAN hypothetical protein kiaa0188 (fragment). L.ETLGAAAPLLPMIEELKPPSAS.V 2 2.469 0.111 O 10/2001 Q12766 homo sapiens (human). S.GVSSKGSVVKRNQQPVTTEQNSSKENAS IPI:IPI00185948.1 SW:Y194_HUMAN hypothetical protein kiaa0194 (fragment). 3 3.989 0.234 O KLTL.E (98%) 10/2001 Q92628 homo sapiens (human). SW:Y232_HUMAN hypothetical protein kiaa0232 (fragment). W.YTEPIAEY.F 1 2.100 0.121 A 10/2001 Q92508 homo sapiens (human). SW:Y233_HUMAN E.VTVADTEPTRTQTLLQS.L 2 3.178 0.112 G hypothetical protein kiaa0233. 10/2001 W.FPLLFMSLVRSVVGVVNQPID.V 2 2.746 0.088 Q92539 homo sapiens (human). IPI:IPI00021956.1 SW:Y249_HUMAN N.WALAAPMILSLQVFQKSL.P 2 2.466 0.283 O hypothetical protein kiaa0249. 10/2001 (95%) O14524 homo sapiens (human). SW:Y286_HUMAN hypothetical protein kiaa0286 (ha6800) L.FFCGDLLSRSQIF.Y 1 2.407 0.110 A (fragment). 10/2001 O15060 homo sapiens (human). IPI:IPI00006589.1 SW:Y352_HUMAN hypothetical zinc finger protein kiaa0352. T.VCGHYSSTLNLMSK.H 1 2.288 0.108 G (96%) 10/2001 O43167 homo sapiens (human). IPI:IPI00011180.1 SW:Y441_HUMAN hypothetical zinc finger protein kiaa0441. K.VYDLVKAYTDFQNNHSSPK.P 2 2.359 0.144 O (91%) 10/2001 Q9ujp4 homo sapiens (human). IPI:IPI00166709.1 SW:Y469_HUMAN P.DHLGGGYSIVALGNDIYVTGGSDGSR.L 2 2.444 0.203 A hypothetical protein kiaa0469. 10/2001 (97%) O60287 homo sapiens (human). IPI:IPI00218714.1 SW:Y539_HUMAN hypothetical protein kiaa0539 (fragment). A.EGLAGPVQE.V 1 2.144 0.191 O (91%) 10/2001 Q9ukj3 homo sapiens (human). SW:Y553_HUMAN E.STALQWPSELLIF.T 2 2.650 0.084 P hypothetical protein kiaa0553. 10/2001 O94876 homo sapiens (human). IPI:IPI00217559.1 SW:Y779_HUMAN hypothetical protein kiaa0779 (fragment). Q.ATHSAAGAVVSKPREIASLIRNKF.G 2 2.885 0.186 O, P (93%) 10/2001 O94967 homo sapiens (human). SW:Y893_HUMAN K.QLPIMVVGEHK.D 1 1.813 0.157 A hypothetical protein kiaa0893. 10/2001 Q9y2e4 homo sapiens (human). IPI:IPI00032087.2 SW:Y934_HUMAN hypothetical protein kiaa0934 (fragment). I.DLIAAFYGCLYAGCVPITVRP.P 2 2.744 0.216 G (96%) 10/2001
Supplementary Table 2 107 Q9upz3 homo sapiens (human). IPI:IPI00010486.2 SW:YA17_HUMAN F.KEFTSQQ.E 1 2.022 0.135 P hypothetical protein kiaa1017. 10/2001 (94%) Q9upv9 homo sapiens (human). IPI:IPI00059783.1 SW:YA42_HUMAN G.PPGPAPALVPR.G 2 2.490 0.130 G hypothetical protein kiaa1042. 10/2001 (93%) Q9ulk2 homo sapiens (human). IPI:IPI00181584.1 SW:YC18_HUMAN hypothetical protein kiaa1218 (fragment). T.SSSAVSTPPLIKPVLMSK.S 2 2.216 0.139 A (97%) 10/2001 Q9um01 homo sapiens (human). y+l amino acid transporter 1 (y(+)l-type IPI:IPI00008300.1 SW:YLA1_HUMAN L.TNVAYYTVLDMRDILASDA.V 2 2.437 0.108 G amino acid transporter 1) (y+lat-1) (93%) (y+lat1). 10/2001 P58317 homo sapiens (human). zinc K.PYECNECGKAYNRFYLLTEHFKTHTEEKP SW:Z121_HUMAN finger protein 121 (zinc finger protein 20) 3 3.533 0.086 A FEC.K (fragment). 10/2001 P52738 homo sapiens (human). zinc IPI:IPI00181877.1 SW:Z140_HUMAN K.SHTGEKPYACAECDK.A 2 2.236 0.149 A finger protein 140. 10/2001 (99%) Q12899 homo sapiens (human). zinc IPI:IPI00183814.1 SW:Z173_HUMAN finger protein 173 (acid finger protein) F.QGKLLRDLEYKTVSVTLDP.Q 2 2.457 0.194 G (93%) (afp). 10/2001 Q9y473 homo sapiens (human). zinc SW:Z175_HUMAN finger protein 175 (zinc finger protein E.VSHQRCQEREFGLEIPQKEISK.K 2 2.337 0.202 P otk18). 10/2001 O15541 homo sapiens (human). zinc S.AKPVGPEDMGATAVYELDTEKERDAQAIF SW:Z183_HUMAN 3 3.790 0.085 O finger protein 183. 10/2001 ER.S O43345 homo sapiens (human). zinc SW:Z208_HUMAN G.KGFVMFSILAKHKVIHTGEK.L 2 2.273 0.115 A finger protein 208. 10/2001 O75362 homo sapiens (human). zinc K.ESGQEGSTDNDDSSSEKELGETNKGSCA IPI:IPI00025310.1 SW:Z217_HUMAN 3 3.707 0.178 A finger protein 217. 10/2001 GLSQEKEK.C (97%) Q9uk11 homo sapiens (human). zinc SW:Z223_HUMAN G.ENPSKCEDCGKRYKRR.L 2 2.351 0.129 O finger protein 223. 10/2001 Q14587 homo sapiens (human). zinc IPI:IPI00031595.1 SW:Z268_HUMAN finger protein 268 (zinc finger protein Q.LIVHQRIHTGENPYECSECGKA.F 2 2.413 0.176 P (98%) hzf3). 10/2001 Q9y493 homo sapiens (human). SW:ZAN_HUMAN K.PSIPTEKPSIPT.E 1 1.924 0.146 G zonadhesin (fragment). 10/2001 P17010 homo sapiens (human). zinc IPI:IPI00012336.1 SW:ZFX_HUMAN Q.DDDKGNCEDYLMISLDDA.G 2 2.649 0.097 A finger x-chromosomal protein. 10/2001 (93%) Q14585 homo sapiens (human). zinc SW:ZH10_HUMAN Y.ECIDCGKAFGSGSNLTQHRRIHTG.E 2 2.481 0.150 G finger protein hzf10. 10/2001 P17097 homo sapiens (human). zinc SW:ZN07_HUMAN finger protein 7 (zinc finger protein kox4) L.IHQRVHTGERPYK.C 2 2.334 0.203 P (zinc finger protein hf.16). 10/2001 P17024 homo sapiens (human). zinc SW:ZN20_HUMAN finger protein 20 (zinc finger protein H.HCGESFNQIADDM.L 2 3.448 0.257 P kox13) (dkfzp572p0920). 10/2001 P13682 homo sapiens (human). zinc IPI:IPI00009932.1 SW:ZN35_HUMAN finger protein 35 (zinc finger protein K.PYECEKCGA.A 1 2.126 0.084 G (97%) hf.10). 10/2001 P15621 homo sapiens (human). zinc finger protein 44 (zinc finger protein SW:ZN44_HUMAN kox7) (gonadotropin inducible P.HKCTVCGKAFDSPSVFQRHER.T 2 2.361 0.103 A transcription repressor-2) (giot-2). 10/2001 P.YECKQCR.K 1 2.296 0.083 P36508 homo sapiens (human). zinc IPI:IPI00218817.1 SW:ZN76_HUMAN D.GQPVQLEDGSMAYIHR.T 2 2.228 0.190 O finger protein 76. 10/2001 (95%) Q03936 homo sapiens (human). zinc SW:ZN92_HUMAN finger protein 92 (zinc finger protein R.KDHKSVDACKVYKGGYNGLNQ.C 2 2.606 0.135 O htf12) (fragment). 10/2001 O43264 homo sapiens (human). SW:ZW10_HUMA centromere/kinetochore protein zw10 F.HLFHDVVPTYHKE.N 2 2.408 0.110 O N homolog. 10/2001 SW:ZXDA_HUMA P98168 homo sapiens (human). zinc A.VPTPAPISAPGPAAAFAGTVTIHNQ.D 2 2.465 0.282 A N finger x-linked protein zxda. 10/2001 Q15942 homo sapiens (human). zyxin SW:ZYX_HUMAN V.SVSAPAFYAPQKKFG.P 2 2.407 0.143 G (zyxin 2). 10/2001 P58397 homo sapiens (human). adamts- 12 precursor (ec 3.4.24.-) (a disintegrin SWN:AT12_HUMA IPI:IPI00185774.1 and metalloproteinase with R.KGDLEKLMATGPTNE.S 1 1.836 0.113 G N (95%) thrombospondin motifs 12) (adam-ts 12) (adam- ts12). 3/2002 Q9bxk1 homo sapiens (human). transcription factor bteb4 (basic SWN:BTE4_HUMA transcription element binding- protein 4) A.PHLLAASILADLRGGPGAAPGGASP.A 2 2.660 0.143 A N (bte-binding protein 4) (novel sp1-like zinc finger transcription factor 2) (transc
Supplementary Table 2 108 SWN:C21B_HUMA P58499 homo sapiens (human). protein IPI:IPI00219789.1 L.LVKLRPKPTANTTCPGLLKVVFVV.F 2 2.516 0.201 P N c21orf11 (protein pred44). 3/2002 (98%) Q9ui42 homo sapiens (human). SWN:CBP4_HUM carboxypeptidase a4 precursor (ec G.SSCIGADPNRNWNA.S 2 2.833 0.126 P AN 3.4.17.-) (carboxypeptidase a3). 3/2002 Q9np87 homo sapiens (human). dna SWN:DPOM_HUM IPI:IPI00002325.1 polymerase mu (ec 2.7.7.7) (pol mu). L.DDLREQPQKLTQQQKAGLQH.H 2 2.572 0.186 O AN (94%) 3/2002 Q14332 homo sapiens (human). frizzled SWN:FZD2_HUMA L.QPGAGGTPGGPGGGGAPPRYATLEHPFH IPI:IPI00016027.1 2 precursor (frizzled-2) (fz-2) (hfz2) 2 2.560 0.136 P N .C (91%) (fze2). 3/2002 Q9h461 homo sapiens (human). frizzled SWN:FZD8_HUMA 8 precursor (frizzled-8) (fz-8) (hfz8). E.DYKKPLPPCRSVCERAKAGCA.P 2 2.440 0.117 A N 3/2002 P83105 homo sapiens (human). SWN:HRA4_HUM IPI:IPI00027860.1 probable serine protease htra4 precursor L.RAGEFVVALGSPFSLQN.T 2 2.426 0.165 P AN (93%) (ec 3.4.21.-). 3/2002 Q9y6n6 homo sapiens (human). laminin SWN:LMG3_HUM IPI:IPI00184790.1 gamma-3 chain precursor (laminin 12 T.GQFCESCAPGYKREMPQGGPYA.S 2 2.756 0.152 A AN (96%) gamma 3). 3/2002 Q14703 homo sapiens (human). membrane-bound transcription factor SWN:MS1P_HUM IPI:IPI00021569.1 site-1 protease precursor (ec 3.4.21.-) V.KERTNWTNERTLDDGLGHG.T 2 2.537 0.156 O AN (95%) (site-1 protease) (subtilisin/kexin- isozyme-1) (ski-1). 3/2002 SWN:PRD5_HUM Q9nqx1 homo sapiens (human). pr- IPI:IPI00032997.1 A.EHLQTLHQ.K 1 2.042 0.157 A AN domain zinc finger protein 5. 3/2002 (97%) TFD:TFDP00561 : HOX 2.2 ((human)) polypeptide Y.GPGPGQDKGFAYSSYYPPAGGGYGR.A 2 2.221 0.180 P
Supplementary Table 2 109