ANTICANCER RESEARCH International Journal of Cancer Research and Treatment
ISSN: 0250-7005
Volume 28, Number 2B, ªarch-April 2008
Contents Clinical Studies * Human Papillomavirus Accounts both for Increased Incidence and Better Prognosis in Tonsillar Cancer. H. DAHLSTRAND, A. NÄSMAN, M. ROMANITAN, D. LINDQUIST, T. RAMQVIST, T. DALIANIS (Stockholm, Sweden) ...... 1133
Peripheral Blood CD8highCD57+ Lymphocyte Levels May Predict Outcome in Melanoma Patients Treated with Adjuvant Interferon-·. D. CHARACIEJUS, V. PA UKONIEN EØ , R. JONU AUSKAITE, N. ˇ ˇ KAZLAUSKAIT EØ , E. ALEKNAVI IUS, M. MAURICAS, WS. DEN OTTER (Vilnius, LSithuania; Utrecht, ˇ The Netherlands) ...... C...... 1139
* The Role of Regulatory T Cells in Malignant Glioma. A.M. SONABEND, C.E. ROLLE, M.S. LESNIAK (Chicago, IL, USA) ...... 1143
Comparison of Apolipoprotein D Determination Methods in Breast Cancer. H. S ILAND, I. SKALAND, E.A.M. JANSSEN, E. GUDLAUGSSON, H. KÖRNER, J.E. VARHAUG, J.A. S Ø REIDE, J.P.A. BAAK (Stavanger; Bergen, Norway; Amsterdam, The Netherlands) ...... Ø...... 1151
Protein Abundance of Class III Beta-tubulin but Not ¢2-Alpha-Tubulin or Tau is Related to Paclitaxel Response in Carcinomas of Unknown Primary Site. P. S EVE, T. REIMAN, S. ISAAC, V. TRILLET-LENOIR, L. ` LAFANÉCH ERE, M. SAWYER, C. DUMONTET (Lyon; Grenoble, France; Edmonton, AB, Canada) ...... 1161 ` Overexpression of RegIV in Peritoneal Dissemination of Gastric Cancer and Its Potential as A Novel Marker for the Detection of Peritoneal Micrometastasis. K. MIYAGAWA, C. SAKAKURA, S. NAKASHIMA, T. YOSHIKAWA, K. FUKUDA, S. KIN, Y. NAKASE, K. SHIMOMURA, N. OUE, W. YASUI, H. HAYASIZAKI, Y. OKAZAKI, H. YAMAGISHI, A. HAGIWARA, E. OTSUJI (Kyoto; Hiroshima; Yokohama; Saitama, Japan) ...... 1169
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Metastatic Embryonal Carcinoma in the Maxillary Gingiva. F. ANGIERO, M. STEFANI (Monza; Milan, Italy) ...... 1181
Chemotherapy Using Hybrid Liposomes along with Induction of Apoptosis. H. ICHIHARA, H. NAGAMI, T. KIYOKAWA, Y. MATSUMOTO, R. UEOKA (Kumamoto Japan) ...... 1187
* Update on Molecular Pathology in Oral Cancer and Precancer. J. CAMPO-TRAPERO, J. CANO- S NCHEZ, B. PALACIOS-S NCHEZ, J.J. S NCHEZ-GUTIERREZ, M.A. GONZ LEZ-MOLES, A. BÁASCONES-MART NEZ (MÁadrid; Granada, SÁpain) ...... Á...... 1197 Í Influence of Resection Volume on Locoregional Recurrence of Breast Cancer after Breast-conserving Surgery. D.U. BOEHM, A. LEBRECHT, T. MALTARIS, M. SCHMIDT, W. SIGGELKOW, S. FISCHER, E. KANDELHART, H. KOELBL (Mainz; Halle, Germany) ...... 1207
* Chemotherapy in Gastric Cancer. E. WÖLL, A. DEVRIES, W. EISTERER, M. HEJNA, F. KEIL, H. STEIN, J. ZACHERL, R. GREIL (Zams; Feldkirch; Innsbruck; Vienna; Leoben; Salzbuirg, Austria) ...... 1213
POLR2F, ATP6V0A1 and PRNP Expression in Colorectal Cancer: New Molecules with Prognostic Significance? A.G. ANTONACOPOULOU, P.D. GRIVAS, L. SKARLAS, M. KALOFONOS, C.D. SCOPA, H.P. KALOFONOS (Rion, Patras, Greece) ...... 1221
Prospective Phase II Study of Post-surgical Adjuvant Chemo-immunotherapy Using Autologous Dendritic Cells and Activated Killer Cells from Tissue Culture of Tumor-draining Lymph Nodes in Primary Lung Cancer Patients. H. KIMURA, T. IIZASA, A. ISHIKAWA, M. SHINGYOUJI, M. YOSHINO, M. KIMURA, Y. INADA, K. MATSUBAYASHI (Chiba, Japan) ...... 1229
Neoadjuvant Paclitaxel for Operable Breast Cancer: Multicenter Phase II Trial with Clinical Outcomes. M. KIMURA, M. SANO, M. FUJIMORI, H. NAKAGOMI, T. NEGISHI, Y. YANAGITA, N. SATO (Ota; Isesaki, Gunma; Niigata; Matsumoto, Nagano; Kofu,Yamanashi, Japan) ...... 1239
* Taxanes and Gemcitabine Doublets in the Management of HER-2 Negative Metastatic Breast Cancer: Towards Optimization of Association and Schedule. G. METRO, A. FABI, M. RUSSILLO, P. PAPALDO, M. DE LAURENTIIS, G. FERRETTI, D. PELLEGRINI, C. NUZZO, V. GRAZIANO, P. VICI, M. INTRONA, A. FELICI, F. COGNETTI, P. CARLINI (Rome; Naples, Italy) ...... 1245
Adjuvant Tamoxifen in Breast Cancer Patients Affects the Endometrium by Time, an Effect Remaining Years after End of Treatment and Results in an Increased Frequency of Endometrial Carcinoma. B. LINDAHL, E. ANDOLF, C. INGVAR, J. RANSTAM, R. WILLÉN (Lund; Stockholm; Uppsala, Sweden) ...... 1259
Development of Cancer in Patients with Primary Immunodeficiencies. K. SALAVOURA, A. KOLIALEXI, G. TSANGARIS, A. MAVROU (Athens, Greece) ...... 1263
Gender-specific Association between Polymorphism of Vascular Endothelial Growth Factor (VEGF 936 C>T) Gene and Colon Cancer in Korea. S.J. BAE, J.W. KIM, H. KANG, S.G. HWANG, D. OH, N.K. KIM (Seongnam, South Korea) ...... 1271
Prognostic Significance of the Local Expression of Interleukin-12 in Patients with Advanced Gastric Cancer. N. NAGASHIMA, Y. NAKAYAMA, Y. INOUE, J. NAGATA, K. MATSUMOTO, N. MINAGAWA, T. KATSUKI, K. SHIBAO, K. HIRATA, T. SAKO, T. HAMADA, N. NAGATA (Kita-Kyushu; Kurate-machi, Japan) ...... 1277
Induction Chemotherapy Followed by Concurrent Chemoradiotherapy in Advanced Head and Neck Squamous Cell Carcinoma. C. BARONE, R. GRILLO, D. DONGIOVANNI, N. BIROCCO, M. RAMPINO, M.G. RUO REDDA, E. GARIBALDI, F. MUNOZ, G. PECORARI, A. CAVALOT, P. GARZINODEMO, L. BUFFONI, L. CIUFFREDA, U. RICARDI, G. CORTESINA, C. GIORDANO, M. FASOLIS, S. BERRONE, O. BERTETTO, M. SCHENA (Torino, Italy) ...... 1285 Contents continued on the preceding page Contents continued
Weekly 24-hour Infusional 5-Fluorouracil as Initial Treatment for Advanced Gastric Cancer with Acute Disseminated Intravascular Coagulation. T.-C. HUANG, K.-H. YEH, A.-L. CHENG, C.-H. HSU (Taipei; Yun-lin, Taiwan, ROC) ...... 1293
Squamous Cell Lung Carcinoma Metastatic to the Breast. W. HSU, S.-M.S.-CHEN, J.-L. WANG, C.-C. HUANG, S.-F. KO (Kaohsiung, Taiwan, ROC) ...... 1299
* Present Treatment and Future Expectations in Advanced Pancreatic Cancer. G.P. STATHOPOULOS, N. ANDROULAKIS, J. SOUGLAKOS, J. STATHOPOULOS, V. GEORGOULIAS (Athens; Heraklion, Greece) ...... 1303
Impact of Palliative Gastrectomy in Patients with Incurable Advanced Gastric Cancer. C. KUNISAKI, H. MAKINO, R. TAKAGAWA, T. OSHIMA, Y. NAGANO, S. FUJII, H. AKIYAMA, Y. OTSUKA, H.A. ONO, T. KOSAKA, Y. ICHIKAWA, H. SHIMADA (Yokohama, Japan) ...... 1309
Association of the Myeloperoxidase Polymorphism with the Risk of Gastric Cancer. P.-I HSU, J.-J. JWO, C.-L. YANG, P.-N. HSU, H.-B. YANG, K.-H. LAI, I.-S. CHEN, S.-K. CHUAH, D.-C. WU, A. CHEN (Kaohsiung; Taipei; Hsin-chu, Taiwan, ROC) ...... 1317
Disease Presentation and Outcome in Young Patients (<40 Years) with Brain Metastases from Malignant Melanoma. C. NIEDER, M. ADAM, S.T. ASTNER (Bod ; Troms , Norway; Weilheim; Munich, Germany) ...... 1325 ø ø Biweekly Pegylated Liposomal Doxorubicin as Second-line Treatment in Patients with Relapsed Ovarian Cancer after Failure of Platinum and Paclitaxel: Results from a Multi-center Phase II Study of the NOGGO. G. OSKAY-OEZCELIK, D. KOENSGEN, H.-J. HINDENBURG, P. KLARE, B. SCHMALFELDT, W. LICHTENEGGER, R. CHEKEROV, S.-E. AL-BATRAN5, U. NEUMANN, J. SEHOULI; The Ovarian Cancer Study Group of the North Eastern German Society of Gynecological Oncology (NOGGO) (Berlin; Munich; Frankfurt, Germany) ...... 1329
Radiotherapy and Chemotherapy in the Conservative Treatment of Anal Canal Carcinoma. N. RAFFETTO, A. MONACO, E. BANELLI (Rome, Italy) ...... 1335 * Inherited Cancer Predisposition Syndromes in Greece. A. APESSOS, E. PAPADOPOULOU, I. BELOGIANNI, S. BARATSIS, J.K. TRIANTAFILLIDIS, P. KOSMIDIS, E. KARYDAS, E. BRIASOULIS, C. PISIOTIS, K. PAPAZISIS, G. NASIOULAS (Maroussi, Athens; Ioannina; Thessaloniki, Greece) ...... 1341
Hypofractionated/Accelerated Radiotherapy with Cytoprotection (HypoARC) Combined with Vinorelbine and Liposomal Doxorubicin for Locally Advanced Non-small Cell Lung Cancer (NSCLC). P.G. TSOUTSOU, M.E. FROUDARAKIS, D. BOUROS, M.I. KOUKOURAKIS (Alexandroupolis, Greece) ...... 1349
Role of Twist in Head and Neck Carcinoma with Lymph Node Metastasis. D.-L. OU, H.-F. CHIEN, C.-L. CHEN, T.-C. LIN, L.-I. LIN (Taipei, Taiwan, ROC) ...... 1355
Solitary Metastasis of a Merkel Cell Tumor to the Urinary Bladder. H. STRASSER, K. AMANN, K.-M. SCHROTT, F.S. KRAUSE (Erlangen, Germany) ...... 1361
Malignant Mesothelioma of the Tunica Vaginalis Testis in a Petrochemical Worker Exposed to Asbestos. S.M. CANDURA, A. CANTO, A. AMATU, M. GERARDINI, G. STELLA, M. MENSI, G. POGGI (Pavia; Voghera, Italy) ...... 1365
Neuroendocrine Carcinoma of the Urinary Bladder: Case Report and Review of the Literature. A. BERTACCINI, D. MARCHIORI, A. CRICCA, M. GAROFALO, C. GIOVANNINI, F. MANFERRARI, T.G. GERACE, R. PERNETTI, G. MARTORANA (Bologna, Italy) ...... 1369
Increased Cancer Mortality in Type 2 Diabetes (ZODIAC-3). G.W.D. LANDMAN, L.J. UBINK- VELTMAAT, N. KLEEFSTRA, B.J. KOLLEN, H.J.G. BILO (Zwolle; Hattem; Groningen, The Netherlands) ...... 1373
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Neuroimmunomodulation in Medical Oncology: Application of Psychoneuroimmunology with Subcutaneous Low-dose IL-2 and the Pineal Hormone Melatonin in Patients with Untreatable Metastatic Solid Tumors. P. LISSONI, F. BRIVIO, L. FUMAGALLI, G. MESSINA, L. VIGORÉ, D. PAROLINI, M. COLCIAGO, F. ROVELLI (Monza; Lecco, Italy) ...... 1377
Neoadjuvant Carboplatin and Vinorelbine Followed by Chemoradiotherapy in Locally Advanced Head and Neck or Oesophageal Squamous Cell Carcinoma: A Phase II Study in Elderly Patients or Patients with Poor Performance Status. H. KOUSSIS, A. SCOLA, F. BERGAMO, S. TONELLO, U. BASSO, P. KARAHONTZITIS, V. CHIARION-SILENI, L. PASETTO, A. RUOL, L. LOREGGIAN, O. LORA, R. BOTTIN, G. MARIONI, M. DONACH, A. JIRILLO (Padova, Italy; Athens, Greece) ...... 1383 * Biological Activity and Clinical Implications of the Matrix Metalloproteinases. M. RYDLOVA, L. HOLUBEC Jr., M. LUDVIKOVA Jr., D. KALFERT, J. FRANEKOVA, C. POVYSIL, M. LUDVIKOVA (Ostrava; Plzen; Hradec Kr a’lové; Prague, Czech Republic) ...... 1389
Expression of EGF and EGFR Strongly Correlates with Metastasis of Pancreatic Ductal Carcinoma. A. PRYCZYNICZ, K. GUZI N’ SKA-USTYMOWICZ, A. KEMONA, J. CZY Z· EWSKA (Bialystok, Poland) ...... 1399
Detection of Oncogenic DNA Viruses in Colorectal Cancer. L. GIULIANI, C. RONCI, D. BONIFACIO, L. DI BONITO, C. FAVALLI, C.F. PERNO, K. SYRJÄNEN, M. CIOTTI (Rome; Trieste, Italy; Turku, Finland) ...... 1405
Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) Detection in Cancer Patients: A Prognostic Marker For Lung Metastases from Solid Malignancies. E.M. KARAPANAGIOTOU, E. PELEKANOU, A. CHARPIDOU, T. TSAGANOS, V. ANAGNOSTOU, D. PLACHOURAS, E.J. GIAMARELLOS-BOURBOULIS, K.N. SYRIGOS (Athens, Greece) ...... 1411
Krukenberg Tumour of the Ovary: A Case Report with Light Microscopy, Immunohistochemistry and Electron Microscopy Study. C. FAZZARI, F. FEDELE, G. PIZZI, C. CRISAFULLI, A. PARISI, R.A. CARUSO (Messina, Italy) ...... 1417
Adult Granulosa Cell Tumors of the Ovary: A Clinicopathological Study of 34 Patients by the Hellenic Cooperative Oncology Group (HeCOG). D. PECTASIDES, G. PAPAXOINIS, G. FOUNTZILAS, G. ARAVANTINOS, E. PECTASIDES, D. MOURATIDOU, T. ECONOMOPOULOS, CH. ANDREADIS (Athens; Thessaloniki, Greece) ...... 1421
Unexpected Clinical Outcome in a Patient with Liver and Brain Metastasis from Melanoma. C. NUZZO, M. ZEULI, V. FERRARESI, M. CICCARESE, D. PELLIGRINI, F. COGNETTI (Rome, Italy) ...... 1429
Combination Chemotherapy of S-1 and Low-dose Twice-Weekly Cisplatin for Advanced and Recurrent Gastric Cancer in an Outpatient Setting: A Retrospective Study. A. TSUJI, Y. SHIMA, S. MORITA, M. UCHIDA, K. OKAMOTO, M. MORITA, T. HORIMI, T. SHIRASAKA (Kochi; Tokyo, Japan) ...... 1433
Errata ...... 1439
* Reviews (pages 1133, 1143, 1197, 1213, 1245, 1303, 1341, 1389)