ANTICANCER RESEARCH International Journal of Cancer Research and Treatment

ISSN: 0250-7005

Volume 28, Number 2B, ªarch-April 2008

Contents Clinical Studies * Human Papillomavirus Accounts both for Increased Incidence and Better Prognosis in Tonsillar Cancer. H. DAHLSTRAND, A. NÄSMAN, M. ROMANITAN, D. LINDQUIST, T. RAMQVIST, T. DALIANIS (Stockholm, Sweden) ...... 1133

Peripheral Blood CD8highCD57+ Lymphocyte Levels May Predict Outcome in Melanoma Patients Treated with Adjuvant Interferon-·. D. CHARACIEJUS, V. PA UKONIEN EØ , R. JONU AUSKAITE, N. ˇ ˇ KAZLAUSKAIT EØ , E. ALEKNAVI IUS, M. MAURICAS, WS. DEN OTTER (Vilnius, LSithuania; Utrecht, ˇ The Netherlands) ...... C...... 1139

* The Role of Regulatory T Cells in Malignant Glioma. A.M. SONABEND, C.E. ROLLE, M.S. LESNIAK (Chicago, IL, USA) ...... 1143

Comparison of Apolipoprotein D Determination Methods in Breast Cancer. H. S ILAND, I. SKALAND, E.A.M. JANSSEN, E. GUDLAUGSSON, H. KÖRNER, J.E. VARHAUG, J.A. S Ø REIDE, J.P.A. BAAK (Stavanger; Bergen, Norway; Amsterdam, The Netherlands) ...... Ø...... 1151

Protein Abundance of Class III Beta-tubulin but Not ¢2-Alpha-Tubulin or Tau is Related to Paclitaxel Response in Carcinomas of Unknown Primary Site. P. S EVE, T. REIMAN, S. ISAAC, V. TRILLET-LENOIR, L. ` LAFANÉCH ERE, M. SAWYER, C. DUMONTET (Lyon; Grenoble, France; Edmonton, AB, Canada) ...... 1161 ` Overexpression of RegIV in Peritoneal Dissemination of Gastric Cancer and Its Potential as A Novel Marker for the Detection of Peritoneal Micrometastasis. K. MIYAGAWA, C. SAKAKURA, S. NAKASHIMA, T. YOSHIKAWA, K. FUKUDA, S. KIN, Y. NAKASE, K. SHIMOMURA, N. OUE, W. YASUI, H. HAYASIZAKI, Y. OKAZAKI, H. YAMAGISHI, A. HAGIWARA, E. OTSUJI (; ; ; , ) ...... 1169

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Metastatic Embryonal Carcinoma in the Maxillary Gingiva. F. ANGIERO, M. STEFANI (Monza; Milan, Italy) ...... 1181

Chemotherapy Using Hybrid Liposomes along with Induction of Apoptosis. H. ICHIHARA, H. NAGAMI, T. KIYOKAWA, Y. MATSUMOTO, R. UEOKA ( Japan) ...... 1187

* Update on Molecular Pathology in Oral Cancer and Precancer. J. CAMPO-TRAPERO, J. CANO- S NCHEZ, B. PALACIOS-S NCHEZ, J.J. S NCHEZ-GUTIERREZ, M.A. GONZ LEZ-MOLES, A. BÁASCONES-MART NEZ (MÁadrid; Granada, SÁpain) ...... Á...... 1197 Í Influence of Resection Volume on Locoregional Recurrence of Breast Cancer after Breast-conserving Surgery. D.U. BOEHM, A. LEBRECHT, T. MALTARIS, M. SCHMIDT, W. SIGGELKOW, S. FISCHER, E. KANDELHART, H. KOELBL (Mainz; Halle, Germany) ...... 1207

* Chemotherapy in Gastric Cancer. E. WÖLL, A. DEVRIES, W. EISTERER, M. HEJNA, F. KEIL, H. STEIN, J. ZACHERL, R. GREIL (Zams; Feldkirch; Innsbruck; Vienna; Leoben; Salzbuirg, Austria) ...... 1213

POLR2F, ATP6V0A1 and PRNP Expression in Colorectal Cancer: New Molecules with Prognostic Significance? A.G. ANTONACOPOULOU, P.D. GRIVAS, L. SKARLAS, M. KALOFONOS, C.D. SCOPA, H.P. KALOFONOS (Rion, Patras, Greece) ...... 1221

Prospective Phase II Study of Post-surgical Adjuvant Chemo-immunotherapy Using Autologous Dendritic Cells and Activated Killer Cells from Tissue Culture of Tumor-draining Lymph Nodes in Primary Lung Cancer Patients. H. KIMURA, T. IIZASA, A. ISHIKAWA, M. SHINGYOUJI, M. YOSHINO, M. KIMURA, Y. INADA, K. MATSUBAYASHI (, Japan) ...... 1229

Neoadjuvant Paclitaxel for Operable Breast Cancer: Multicenter Phase II Trial with Clinical Outcomes. M. KIMURA, M. SANO, M. FUJIMORI, H. NAKAGOMI, T. NEGISHI, Y. YANAGITA, N. SATO (Ota; Isesaki, Gunma; ; Matsumoto, ; Kofu,Yamanashi, Japan) ...... 1239

* Taxanes and Gemcitabine Doublets in the Management of HER-2 Negative Metastatic Breast Cancer: Towards Optimization of Association and Schedule. G. METRO, A. FABI, M. RUSSILLO, P. PAPALDO, M. DE LAURENTIIS, G. FERRETTI, D. PELLEGRINI, C. NUZZO, V. GRAZIANO, P. VICI, M. INTRONA, A. FELICI, F. COGNETTI, P. CARLINI (Rome; Naples, Italy) ...... 1245

Adjuvant Tamoxifen in Breast Cancer Patients Affects the Endometrium by Time, an Effect Remaining Years after End of Treatment and Results in an Increased Frequency of Endometrial Carcinoma. B. LINDAHL, E. ANDOLF, C. INGVAR, J. RANSTAM, R. WILLÉN (Lund; Stockholm; Uppsala, Sweden) ...... 1259

Development of Cancer in Patients with Primary Immunodeficiencies. K. SALAVOURA, A. KOLIALEXI, G. TSANGARIS, A. MAVROU (Athens, Greece) ...... 1263

Gender-specific Association between Polymorphism of Vascular Endothelial Growth Factor (VEGF 936 C>T) Gene and Colon Cancer in Korea. S.J. BAE, J.W. KIM, H. KANG, S.G. HWANG, D. OH, N.K. KIM (Seongnam, South Korea) ...... 1271

Prognostic Significance of the Local Expression of Interleukin-12 in Patients with Advanced Gastric Cancer. N. NAGASHIMA, Y. NAKAYAMA, Y. INOUE, J. NAGATA, K. MATSUMOTO, N. MINAGAWA, T. KATSUKI, K. SHIBAO, K. HIRATA, T. SAKO, T. HAMADA, N. NAGATA (Kita-Kyushu; Kurate-machi, Japan) ...... 1277

Induction Chemotherapy Followed by Concurrent Chemoradiotherapy in Advanced Head and Neck Squamous Cell Carcinoma. C. BARONE, R. GRILLO, D. DONGIOVANNI, N. BIROCCO, M. RAMPINO, M.G. RUO REDDA, E. GARIBALDI, F. MUNOZ, G. PECORARI, A. CAVALOT, P. GARZINODEMO, L. BUFFONI, L. CIUFFREDA, U. RICARDI, G. CORTESINA, C. GIORDANO, M. FASOLIS, S. BERRONE, O. BERTETTO, M. SCHENA (Torino, Italy) ...... 1285 Contents continued on the preceding page Contents continued

Weekly 24-hour Infusional 5-Fluorouracil as Initial Treatment for Advanced Gastric Cancer with Acute Disseminated Intravascular Coagulation. T.-C. HUANG, K.-H. YEH, A.-L. CHENG, C.-H. HSU (Taipei; Yun-lin, Taiwan, ROC) ...... 1293

Squamous Cell Lung Carcinoma Metastatic to the Breast. W. HSU, S.-M.S.-CHEN, J.-L. WANG, C.-C. HUANG, S.-F. KO (Kaohsiung, Taiwan, ROC) ...... 1299

* Present Treatment and Future Expectations in Advanced Pancreatic Cancer. G.P. STATHOPOULOS, N. ANDROULAKIS, J. SOUGLAKOS, J. STATHOPOULOS, V. GEORGOULIAS (Athens; Heraklion, Greece) ...... 1303

Impact of Palliative Gastrectomy in Patients with Incurable Advanced Gastric Cancer. C. KUNISAKI, H. MAKINO, R. TAKAGAWA, T. OSHIMA, Y. NAGANO, S. FUJII, H. AKIYAMA, Y. OTSUKA, H.A. ONO, T. KOSAKA, Y. ICHIKAWA, H. SHIMADA (Yokohama, Japan) ...... 1309

Association of the Myeloperoxidase Polymorphism with the Risk of Gastric Cancer. P.-I HSU, J.-J. JWO, C.-L. YANG, P.-N. HSU, H.-B. YANG, K.-H. LAI, I.-S. CHEN, S.-K. CHUAH, D.-C. WU, A. CHEN (Kaohsiung; Taipei; Hsin-chu, Taiwan, ROC) ...... 1317

Disease Presentation and Outcome in Young Patients (<40 Years) with Brain Metastases from Malignant Melanoma. C. NIEDER, M. ADAM, S.T. ASTNER (Bod ; Troms , Norway; Weilheim; Munich, Germany) ...... 1325 ø ø Biweekly Pegylated Liposomal Doxorubicin as Second-line Treatment in Patients with Relapsed Ovarian Cancer after Failure of Platinum and Paclitaxel: Results from a Multi-center Phase II Study of the NOGGO. G. OSKAY-OEZCELIK, D. KOENSGEN, H.-J. HINDENBURG, P. KLARE, B. SCHMALFELDT, W. LICHTENEGGER, R. CHEKEROV, S.-E. AL-BATRAN5, U. NEUMANN, J. SEHOULI; The Ovarian Cancer Study Group of the North Eastern German Society of Gynecological Oncology (NOGGO) (Berlin; Munich; Frankfurt, Germany) ...... 1329

Radiotherapy and Chemotherapy in the Conservative Treatment of Anal Canal Carcinoma. N. RAFFETTO, A. MONACO, E. BANELLI (Rome, Italy) ...... 1335 * Inherited Cancer Predisposition Syndromes in Greece. A. APESSOS, E. PAPADOPOULOU, I. BELOGIANNI, S. BARATSIS, J.K. TRIANTAFILLIDIS, P. KOSMIDIS, E. KARYDAS, E. BRIASOULIS, C. PISIOTIS, K. PAPAZISIS, G. NASIOULAS (Maroussi, Athens; Ioannina; Thessaloniki, Greece) ...... 1341

Hypofractionated/Accelerated Radiotherapy with Cytoprotection (HypoARC) Combined with Vinorelbine and Liposomal Doxorubicin for Locally Advanced Non-small Cell Lung Cancer (NSCLC). P.G. TSOUTSOU, M.E. FROUDARAKIS, D. BOUROS, M.I. KOUKOURAKIS (Alexandroupolis, Greece) ...... 1349

Role of Twist in Head and Neck Carcinoma with Lymph Node Metastasis. D.-L. OU, H.-F. CHIEN, C.-L. CHEN, T.-C. LIN, L.-I. LIN (Taipei, Taiwan, ROC) ...... 1355

Solitary Metastasis of a Merkel Cell Tumor to the Urinary Bladder. H. STRASSER, K. AMANN, K.-M. SCHROTT, F.S. KRAUSE (Erlangen, Germany) ...... 1361

Malignant Mesothelioma of the Tunica Vaginalis Testis in a Petrochemical Worker Exposed to Asbestos. S.M. CANDURA, A. CANTO, A. AMATU, M. GERARDINI, G. STELLA, M. MENSI, G. POGGI (Pavia; Voghera, Italy) ...... 1365

Neuroendocrine Carcinoma of the Urinary Bladder: Case Report and Review of the Literature. A. BERTACCINI, D. MARCHIORI, A. CRICCA, M. GAROFALO, C. GIOVANNINI, F. MANFERRARI, T.G. GERACE, R. PERNETTI, G. MARTORANA (Bologna, Italy) ...... 1369

Increased Cancer Mortality in Type 2 Diabetes (ZODIAC-3). G.W.D. LANDMAN, L.J. UBINK- VELTMAAT, N. KLEEFSTRA, B.J. KOLLEN, H.J.G. BILO (Zwolle; Hattem; Groningen, The Netherlands) ...... 1373

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Neuroimmunomodulation in Medical Oncology: Application of Psychoneuroimmunology with Subcutaneous Low-dose IL-2 and the Pineal Hormone Melatonin in Patients with Untreatable Metastatic Solid Tumors. P. LISSONI, F. BRIVIO, L. FUMAGALLI, G. MESSINA, L. VIGORÉ, D. PAROLINI, M. COLCIAGO, F. ROVELLI (Monza; Lecco, Italy) ...... 1377

Neoadjuvant Carboplatin and Vinorelbine Followed by Chemoradiotherapy in Locally Advanced Head and Neck or Oesophageal Squamous Cell Carcinoma: A Phase II Study in Elderly Patients or Patients with Poor Performance Status. H. KOUSSIS, A. SCOLA, F. BERGAMO, S. TONELLO, U. BASSO, P. KARAHONTZITIS, V. CHIARION-SILENI, L. PASETTO, A. RUOL, L. LOREGGIAN, O. LORA, R. BOTTIN, G. MARIONI, M. DONACH, A. JIRILLO (Padova, Italy; Athens, Greece) ...... 1383 * Biological Activity and Clinical Implications of the Matrix Metalloproteinases. M. RYDLOVA, L. HOLUBEC Jr., M. LUDVIKOVA Jr., D. KALFERT, J. FRANEKOVA, C. POVYSIL, M. LUDVIKOVA (Ostrava; Plzen; Hradec Kr a’lové; Prague, Czech Republic) ...... 1389

Expression of EGF and EGFR Strongly Correlates with Metastasis of Pancreatic Ductal Carcinoma. A. PRYCZYNICZ, K. GUZI N’ SKA-USTYMOWICZ, A. KEMONA, J. CZY Z· EWSKA (Bialystok, Poland) ...... 1399

Detection of Oncogenic DNA Viruses in Colorectal Cancer. L. GIULIANI, C. RONCI, D. BONIFACIO, L. DI BONITO, C. FAVALLI, C.F. PERNO, K. SYRJÄNEN, M. CIOTTI (Rome; Trieste, Italy; Turku, Finland) ...... 1405

Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) Detection in Cancer Patients: A Prognostic Marker For Lung Metastases from Solid Malignancies. E.M. KARAPANAGIOTOU, E. PELEKANOU, A. CHARPIDOU, T. TSAGANOS, V. ANAGNOSTOU, D. PLACHOURAS, E.J. GIAMARELLOS-BOURBOULIS, K.N. SYRIGOS (Athens, Greece) ...... 1411

Krukenberg Tumour of the Ovary: A Case Report with Light Microscopy, Immunohistochemistry and Electron Microscopy Study. C. FAZZARI, F. FEDELE, G. PIZZI, C. CRISAFULLI, A. PARISI, R.A. CARUSO (Messina, Italy) ...... 1417

Adult Granulosa Cell Tumors of the Ovary: A Clinicopathological Study of 34 Patients by the Hellenic Cooperative Oncology Group (HeCOG). D. PECTASIDES, G. PAPAXOINIS, G. FOUNTZILAS, G. ARAVANTINOS, E. PECTASIDES, D. MOURATIDOU, T. ECONOMOPOULOS, CH. ANDREADIS (Athens; Thessaloniki, Greece) ...... 1421

Unexpected Clinical Outcome in a Patient with Liver and Brain Metastasis from Melanoma. C. NUZZO, M. ZEULI, V. FERRARESI, M. CICCARESE, D. PELLIGRINI, F. COGNETTI (Rome, Italy) ...... 1429

Combination Chemotherapy of S-1 and Low-dose Twice-Weekly Cisplatin for Advanced and Recurrent Gastric Cancer in an Outpatient Setting: A Retrospective Study. A. TSUJI, Y. SHIMA, S. MORITA, M. UCHIDA, K. OKAMOTO, M. MORITA, T. HORIMI, T. SHIRASAKA (Kochi; , Japan) ...... 1433

Errata ...... 1439

* Reviews (pages 1133, 1143, 1197, 1213, 1245, 1303, 1341, 1389)