PRODUCT INFORMATION Item No. 19538 O O

CAS Registry No.: 2751-09-9 H O Formal Name: , 2′′,4′,11-triacetate O O O

Synonyms: NSC 108166, O Triacetyloleandomycin, Wy 651 O MF: C41H67NO15 O O FW: 814.0 H H O O Purity: ≥98% O O Supplied as: A solid O Storage: -20°C N Stability: ≥2 years Information represents the product specifications. Batch specific analytical results are provided on each certificate of analysis.

Laboratory Procedures

Troleandomycin is supplied as a solid. A stock solution may be made by dissolving the troleandomycin in the solvent of choice, which should be purged with an inert gas. Troleandomycin is soluble in organic solvents such as ethanol and DMSO. The solubility of troleandomycin in these solvents is approximately 25 and 50 mM, respectively.

Description

Troleandomycin is a and derivative of oleandomycin (Item No. 16552).1,2 It is active against Gram-positive cocci, such as Staphylococcus, as well as the Gram-negative bacteria Neisseria, Haemophilus, and Brucella.1,3 Troleandomycin (50 mg/kg per day) increases survival in a rhesus monkey model of systemic S. aureus infection.4 It also inhibits the 6β-hydroxylase activity of (CYP) isoform CYP3A4 in human microsomes.5 Formulations containing troleandomycin have previously been used in the treatment of asthma.

References

1. Spector, S.L., Katz, F.H., and Farr, R.S. Troleandomycin: Effectiveness in -dependent asthma and bronchitis. J. Clin. Immunol. 54(6), 367-379 (1974). 2. Ross, S. , oleandomycin and triacetyloleandomycin. Pediatr. Clin. North Am. 15(1), 119-129 (1968). 3. Lefebvre, M., Beliveau, D., Desilets, R., et al. Triacetyloleandomycin; A report on its use in different infectious diseases. Can. Med. Assoc. J. 80(5), 346-350 (1959). 4. Saslaw, S. and Carlisle, H.N. Studies on therapy of staphylococcal infections in monkeys. I. Comparison of cloxacillin, triacetyloleandomycin and erythromycin. Proc. Soc. Exp. Biol. Med. 125(4), 1168-1173 (1967). 5. Yamazaki, H. and Shimada, T. Comparative studies of in vitro inhibition of cytochrome P450 3A4-dependent testosterone 6β-hydroxylation by and its metabolites, troleandomycin, and erythromycin. Drug Metab. Dispos. 26(11), 1053-1057 (1998).

WARNING CAYMAN CHEMICAL THIS PRODUCT IS FOR RESEARCH ONLY - NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. 1180 EAST ELLSWORTH RD SAFETY DATA ANN ARBOR, MI 48108 · USA This material should be considered hazardous until further information becomes available. Do not ingest, inhale, get in eyes, on skin, or on clothing. Wash thoroughly after handling. Before use, the user must review the complete Safety Data Sheet, which has been sent via email to your institution. PHONE: [800] 364-9897

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