Cbs Overdosage Is Necessary and Sufficient To

1 SUPPORTING INFORMATION

3 CBS OVERDOSAGE IS NECESSARY AND SUFFICIENT TO

4 INDUCE COGNITIVE PHENOTYPES IN MOUSE MODELS OF

5 DOWN SYNDROME AND INTERACTS GENETICALLY WITH

6 DYRK1A

8 AUTHORS

9 Damien Marechal1,2,3,4, Véronique Brault1,2,3,4, Alice Leon5, Dehren Martin1,2,3,4, Patricia

10 Lopes Pereira6, Nadege Loaëc5, Marie-Christine Birling7, Gaelle Friocourt5,#, Marc

11 Blondel5,# and Yann Herault1,2,3,4,7,*

12 Affiliations

13 1 Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, 1 rue Laurent 14 Fries, 67404 Illkirch, France

15 2 Centre National de la Recherche Scientifique, UMR7104, Illkirch, France

16 3 Institut National de la Santé et de la Recherche Médicale, U1258, Illkirch, France

17 4 Université de Strasbourg, Illkirch, France. 18 5 Inserm UMR 1078, Université de Bretagne Occidentale, Faculté de Médecine et des

19 Sciences de la Santé, Etablissement Français du Sang (EFS) Bretagne, CHRU Brest,

20 Hôpital Morvan, Laboratoire de Génétique Moléculaire, Brest, France.

21 6 Transgenese et Archivage Animaux Modèles, TAAM, CNRS, UPS44, 3B rue de la

22 Férollerie 45071 Orléans, France

23 7 CELPHEDIA, PHENOMIN, Institut Clinique de la Souris, ICS, 1 rue Laurent Fries,

24 67404 Illkirch, France

25 # Both authors contributed equally.

26 * Corresponding author: Yann Hérault

29 Genotype identification

30 The genotypes of the different alleles used in the study were assigned after PCR

31 amplification on isolated genomic DNA (95°C / 5min; 35 cyles (95°C / 45sec, specific

32 Tm / 45sec, 68°C / 1min), 68° 5min) with the use of the specific pairs of primers listed

33 in the supplementary table 1. The Dp1Yah genotype was determined as described

34 previously (1).

35 Behavioural protocols

36 The circadian activity was measured to assess spontaneous activity and

37 feeding behaviour over the complete light/dark cycle. Testing was performed in 38 individual cages (11 x 21 x 18 cm) fitted with infrared captors linked to an electronic

39 interface (Imetronic, Pessac, France) that provided automated measures of position

40 and locomotor activity. Mice were put into cages at 11 am on the first day and removed

41 on the next day at 7 pm. The light cycle was set as 12 h light and 12 h dark (light on at

42 7 am). The 32 hours of testing were divided into three different phases: the habituation

43 phase (from 11 am to 7 pm on the first day); the night/dark phase (from 7 pm on the

44 first day to 7 am on the second day); and the day/light phase (from 7 am to 7 pm on

45 the second day). Feeding behaviour was evaluated using an automated lickometer

46 (Imetronic, Pessac, France) and a 20 mg pellet feeder (Test Diet, Hoffman La-Roche).

47 For the open field paradigm, mice were tested in a 55 cm diameter white round

48 box and mouse activity was recorded with a video tracking system (Ethovision, Noldus,

49 France) during a unique session of 30 min. The arenas were placed in a room

50 homogeneously illuminated at 50 Lux. Each mouse was placed at the periphery of the

51 open-field and allowed to explore the apparatus freely for 30 min with the experimenter

52 out of the animal’s sight. The distance travelled and time spent in the central and

53 peripheral regions were recorded over the test session. The number of entries and the

54 percentage of time spent in the centre area are used as indexes of

55 emotionality/anxiety.

56 The object recognition task was performed in the same conditions as the

57 open-field (see above). The objects to be discriminated were a glass marble (2.5 cm

58 diameter) and a plastic dice (2 cm). The animals were first habituated to the open-field

59 for 30 min. The next day, they were submitted to a 10 min acquisition trial during which

60 they were placed in the open-field in the presence of two similar objects A (marble or

61 dice). The time the animal took to explore the object A (when the animal’s snout was 62 directed towards the object at a distance ≤ 1 cm) was recorded manually. A 10 min

63 retention trial was performed 1 h later. During this trial, one of the familiar objects was

64 changed for a new one in the open-field, and the times tA and tB that the animal took

65 to explore the two objects were recorded. We used a minimal time of three seconds to

66 select animals during the acquisition trial,and the retention trial. The exploration index

67 for object B was defined as (tB / (tA + tB)) x100. Memory was defined by the percentage

68 of time animals spent investigating the novel object statistically different from the

69 chance (50%). We also noted activity parameters such as speed, distance and the

70 time spent in the centre and at the periphery of the apparatus. To control for odour

71 cues, the arena and the objects were thoroughly cleaned with 50% ethanol, dried, and

72 ventilated for a few minutes between sessions. Animals visiting less than 15 arms

73 during the 6 min trial were excluded from the analyses.

74 The Y-maze evaluates the immediate working memory. It is composed of three

75 identical arms but with three different motifs on the wall. The animals were placed at

76 the end of one arm, and were left free to explore the maze during 6 minutes. We

77 recorded the number and the sequence of visited arms. A visit is defined as a complete

78 entrance with the 4 paws in the arm. After the session, we calculated a memory index

79 with the percentage of spontaneous alternation: A= (number of 3 consecutive different

80 visits / total of visited arms minus 2) x 100.

81 The Morris water maze was used to test spatial learning and memory. The

82 water maze is a circular pool (150-cm diameter, 60-cm height) filled with 40 cm with

83 water maintained at 20°C–22°C, made opaque using a white aqueous emulsion

84 (Acusol OP 301 opacifier). The surface was split into 4 quadrants: South-East (SE),

85 North-West (NW), North-East (NE), South-West (SW). The escape platform, made of 86 rough plastic, was submerged 1 cm below the water’s surface. Experiments were

87 performed to study reference memory through a spatial search strategy that involved

88 finding the hidden platform. The spatial memory session consisted of a 6-day (J1 to

89 J6) learning phase with four 90-second trials per day. Each trial started with mice facing

90 the interior wall of the pool and ended when they climbed onto the platform located on

91 the SE quadrant or after a maximum searching time of 90 sec. The starting position

92 was changed pseudo-randomly between trials. Mice were left undisturbed in their

93 home cage for 90-min inter-trial intervals. On the seventh day, mice were given the 60-

94 sec probe test in which the platform had been removed. The distance traveled in each

95 quadrant (NW, NE, SW, SE) was recorded as well as the time spent in the target

96 quadrant.

97 Motor coordination was assessed with the rotarod during the training and the

98 test phases. The evaluation criterion is the time that the mouse spends on the rotating

99 rod before falling. The apparatus (Bioseb, France) is made of a rotating bar of 5 cm

100 diameter on which mice are placed facing the direction of rotation. The test was divided

101 in 3 phases: a habituation phase of 2 min on the road at 4 rpm; a training phase in

102 which each mouse had 4 trials per day, on 3 consecutive days. This step is an

103 accelerated mode (ARR) from 4 to 40 rpm spread on 5 minutes. The last phase is

104 based on constant speed sessions (FSRR), the 4th day of the test; it consisted of 7

105 trials of 2 minutes, each trial at one selected speed (4, 10, 16, 22, 28, 34 and 40 rpm)

106 and this procedure was repeated twice. For each trial of the four days (training + test),

107 the time until the mouse fell off the rod was recorded as well as the corresponding

108 speed. This protocol is adapted from (2).

109 References 110

111 1. Pereira PL, et al. (2009) A new mouse model for the trisomy of the Abcg1-U2af1 112 region reveals the complexity of the combinatorial genetic code of down 113 syndrome. Human Molecular Genetics 18(24):4756-4769.

114 2. Duchon A, et al. (2011) The telomeric part of the human chromosome 21 from 115 Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits 116 observed in the Tc1 mouse model of Down syndrome. Behavioural Brain 117 Research 217(2):271-281.

118

119 Supplementary table 1: Primers/probes used for genotyping.

Tm Size of Mouse lines Primers Sequences5’-3’ (°C) Amplicon Tg(Camk2a-cre) Cre-fo CTGCATTACCGGTCGATGCA 57 355 bp Cre-rev ACGTTCACCGGCATCAACGT Tg(Prp-gfp-CBS) Myo-fo ATCCTGGAGATGGACCACTTGG 58 250 bp GATGAGTTTGGACAAACCACA Myo-re ACTAGAATGC hCBS-fo (b) CTCCCGGGACGAATTCGCAC 58 320 bp TCTTGTTGATTCTGACCATAGGGGTG hCBS-re (b) TC pA-fo (c) ATCCTGGAGATGGACCACTTCGC 58 315 bp GATGAGTTTGGACAAACCACAACTA pA-re (c) GAATGC Tg(Prp-Gfp-CBS)-fo (a) GCATTCTGCCTTCCTAGTGG 58 1159 bp* Tg(Prp-Gfp-CBS)-re (a) GCTCCTTGGCTTCCTTATCC 247 bp** Cbstm1Unc Cbs-commun-fo GGTCTGGAATTCACTATGTAGC 62 Cbs-wt-re AAGAGCCCAGCAGAATGAACA 260 bp§ Cbs-tm1Unc-re GAGGTCGACGGTATCGATA 190 bp§§ Tg(CBS) Tg(CBS)-fo TGTTTCACCAAGGAA ATATTGAGA 60 264 bp Tg(CBS)-re AAATGCCGCTGATTGTTCAC Tg(Dyrk1a) Tg(Dyrk1a)-fo TGG GCC AAG CAG TTA GGA GTT T 60 230 bp CCA TGA TTA CGC CAA GCT ATT Tg(Dyrk1a)-re TAG G mFez-fo GCT TCG GGA GCA GGT ACC CTA T 60 185 bp MFez-re CAA GAT CTG AGG CTC GCC AAG T

120 (fo: forward; re: reverse; * before and **after Cre excision; § wt and §§ mutant Cbs alleles)

121 Supplementary table 2: antibodies used for the Western Blot Primary Species Dilution Supplier antibodies Alpha-synuclein Mouse 1/1000 BD transduction laboratories #610787 Snap25 Goat 1/500 Santa cruz sc-7538 Fus Rabbit 1/1000 Sigma-aldrich HPA008784 Secondary antibodies Species Dilution Supplier Anti-mouse HRP Goat 1/5000 Dako P0448 Anti-goat HRP Donkey 1/5000 Santa cruz sc-2020 Anti-rabbit HRP Goat 1/5000 Molecular probes A16096

122

123 Supplementary table 3: list of proteins detected from quantitative proteomic in

124 the mutant hippocampi of Dp1Yah (Dp), Tg(Dyrk1a) (Tg) or double mutant mice

125 (Dp,Tg). No for no overexpression detected.

126

127 Supplementary table 4: List of ontology terms enriched in the mutant

128 hippocampi of Dp1Yah (Dp), Tg(Dyrk1a) (Tg) or double mutant mice (Dp,Tg).

129 Supplementary Table 3: Quantitative Proteomic analysis of the hippocampi derived from Dp1Yah (Dp), Tg(Dyrk1a ) (Tg) and the [ Dp1Yah (Dp); Tg(Dyrk1a)] (Dp-Tg) animals

Code Symbol Name Nb Dp Mean Dp Nb Tg Mean Tg Nb Dp-Tg Mean Dp-Tg Variability [%] =<40 Mis-expressed D3Z7P3 Gls glutaminase 4 1,05 4 1,02 5 1,13 28,27 No O08553 Dpysl2 dihydropyrimidinase-like 2 4 1,09 4 1,07 5 1,06 31,84 No O08599 Stxbp1 syntaxin binding protein 1 4 1,11 4 1,12 5 1,03 31,42 No O08709 Prdx6 peroxiredoxin 6 4 1,15 4 0,97 5 1,13 27,42 No O08749 Dld dihydrolipoamide dehydrogenase 4 1,10 4 1,10 5 1,17 21,56 No O08756 Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 2 1,09 2 1,11 3 1,12 20,40 No O08788 Dctn1 dynactin 1 4 0,99 4 1,08 5 0,99 25,24 No O35129 Phb2 prohibitin 2 4 1,12 4 1,07 5 1,07 15,23 No O35143 Atpif1 ATPase inhibitory factor 1 3 1,04 3 1,12 4 1,13 24,25 No O35215 Ddt D-dopachrome tautomerase 2 1,04 3 1,01 4 1,04 14,33 No O35643 Ap1b1 adaptor protein complex AP-1, beta 1 subunit 4 1,05 4 1,17 5 1,09 22,25 No O35658 C1qbp complement component 1, q subcomponent binding protein 4 1,08 4 1,11 5 1,17 17,17 No O35857 Timm44 translocase of inner mitochondrial membrane 44 2 1,17 2 1,07 3 1,00 31,06 No O54983 Crym crystallin, mu 4 1,00 4 0,94 5 1,07 25,18 No O54991 Cntnap1 contactin associated protein-like 1 3 1,17 3 1,08 4 1,07 28,36 No O55131 Sept7 septin 7 4 1,03 4 1,10 5 1,02 21,80 No O55143 Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 4 1,17 4 1,04 5 1,11 20,78 No O70443 Gnaz guanine nucleotide binding protein, alpha z subunit 4 1,12 4 0,90 5 1,02 20,20 No O88342 Wdr1 WD repeat domain 1 4 1,15 4 1,13 5 1,11 27,49 No O88447 Klc1 kinesin light chain 1 2 1,08 2 1,11 3 1,10 22,73 No O88531 Ppt1 palmitoyl-protein thioesterase 1 4 1,09 4 1,07 5 0,98 25,29 No O88569 Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 3 1,12 4 1,01 4 1,09 17,69 No O88685 Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 2 1,15 2 1,15 3 1,04 29,01 No O88844 Idh1 isocitrate dehydrogenase 1 (NADP+), soluble 4 1,02 4 0,97 5 0,95 17,15 No O88935 Syn1 synapsin I 4 1,16 4 1,18 5 1,17 22,99 No P00920 Car2 carbonic anhydrase 2 4 1,07 4 1,10 5 1,02 17,50 No P02088 Hbb-b1 hemoglobin, beta adult major chain 3 0,95 3 1,09 4 1,13 23,31 No P05063 Aldoc aldolase C, fructose-bisphosphate 3 1,04 3 1,14 4 1,08 20,65 No P05064 Aldoa aldolase A, fructose-bisphosphate 4 0,90 4 1,04 5 1,10 21,16 No P05201 Got1 glutamate oxaloacetate transaminase 1, soluble 4 1,06 4 1,09 5 1,03 25,07 No P06151 Ldha lactate dehydrogenase A 4 1,09 4 1,11 5 1,10 21,19 No P06745 Gpi1 glucose phosphate isomerase 1 4 1,19 4 1,11 5 1,10 26,25 No P06801 Me1 malic enzyme 1, NADP(+)-dependent, cytosolic 4 1,17 4 1,17 4 1,12 14,08 No P07901 Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 4 1,10 4 1,05 5 1,10 22,26 No P08113 Hsp90b1 heat shock protein 90, beta (Grp94), member 1 3 1,19 4 1,03 4 1,08 18,11 No P08249 Mdh2 malate dehydrogenase 2, NAD (mitochondrial) 4 1,04 4 1,07 5 1,11 21,96 No P08553 Nefm neurofilament, medium polypeptide 3 1,15 3 1,09 4 0,97 20,99 No P09103 P4hb prolyl 4-hydroxylase, beta polypeptide 4 1,12 4 1,09 5 1,11 11,83 No P10637 Mapt microtubule-associated protein tau 3 1,13 3 1,09 4 1,20 20,38 No P11499 Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 4 1,17 4 1,00 5 1,15 27,18 No P12382 Pfkl phosphofructokinase, liver, B-type 4 1,13 4 1,11 5 1,07 19,28 No P12960 Cntn1 contactin 1 4 1,16 4 0,92 5 0,99 18,64 No P13595 Ncam1 neural cell adhesion molecule 1 3 1,12 4 1,11 4 1,12 15,86 No P14231 Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2 1,18 3 1,03 3 1,05 17,02 No P14685 Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 3 1,02 3 1,06 4 1,02 13,97 No P14873 Map1b microtubule-associated protein 1B 4 1,11 4 1,04 5 1,08 22,23 No P15105 Glul glutamate-ammonia ligase (glutamine synthetase) 4 1,12 4 1,04 5 1,08 24,60 No P15532 Nme1 NME/NM23 nucleoside diphosphate kinase 1 4 0,97 4 1,04 5 1,10 21,98 No P16125 Ldhb lactate dehydrogenase B 4 1,15 4 1,14 5 1,13 22,35 No P16330 Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase 4 1,10 4 1,15 5 1,04 25,36 No P16546 Sptan1 spectrin alpha, non-erythrocytic 1 4 1,14 4 1,03 5 1,03 26,48 No P16858 Gapdh glyceraldehyde-3-phosphate dehydrogenase 4 1,01 4 1,09 5 1,02 28,40 No P17182 Eno1 enolase 1, alpha non-neuron 4 0,99 4 1,06 5 1,03 31,62 No P17183 Eno2 enolase 2, gamma neuronal 4 1,09 4 1,14 5 1,06 23,58 No P17426 Ap2a1 adaptor-related protein complex 2, alpha 1 subunit 3 1,15 3 1,13 4 1,10 25,88 No P17427 Ap2a2 adaptor-related protein complex 2, alpha 2 subunit 4 1,13 4 1,19 5 1,12 25,02 No P17710 Hk1 hexokinase 1 4 1,07 4 1,09 5 1,08 17,76 No P17751 Tpi1 triosephosphate isomerase 1 4 1,00 4 1,02 5 1,04 21,73 No P18760 Cfl1 cofilin 1, non-muscle 4 1,00 3 1,08 5 0,97 27,88 No P19096 Fasn fatty acid synthase 4 1,15 4 1,15 5 1,06 26,66 No P19246 Nefh neurofilament, heavy polypeptide 2 1,18 2 1,11 3 0,99 15,15 No P20357 Map2 microtubule-associated protein 2 4 1,16 4 1,06 5 1,15 26,11 No P22723 Gabrg2 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 2 1,06 2 1,20 2 1,14 19,72 No P23116 Eif3a eukaryotic translation initiation factor 3, subunit A 4 1,02 4 1,01 5 1,06 29,79 No P26443 Glud1 glutamate dehydrogenase 1 4 1,00 4 0,89 4 0,99 23,92 No P26638 Sars seryl-aminoacyl-tRNA synthetase 2 1,17 2 1,06 3 1,00 16,33 No P27659 Rpl3 ribosomal protein L3 4 1,13 4 1,06 5 1,13 20,77 No P28652 Camk2b calcium/calmodulin-dependent protein kinase II, beta 3 1,19 4 0,99 4 1,13 12,38 No P28660 Nckap1 NCK-associated protein 1 4 1,18 4 1,11 5 1,09 26,40 No P28663 Napb N-ethylmaleimide sensitive fusion protein attachment protein beta 2 1,14 3 1,18 3 1,15 21,29 No P29341 Pabpc1 poly(A) binding protein, cytoplasmic 1 2 1,08 2 1,11 3 0,99 15,96 No P30275 Ckmt1 creatine kinase, mitochondrial 1, ubiquitous 4 1,02 3 1,07 5 1,06 26,86 No P31324 Prkar2b protein kinase, cAMP dependent regulatory, type II beta 2 1,04 2 1,06 2 1,00 22,34 No P35235 Ptpn11 protein tyrosine phosphatase, non-receptor type 11 2 1,06 3 1,15 3 1,15 12,48 No P35486 Pdha1 pyruvate dehydrogenase E1 alpha 1 2 1,05 2 1,16 3 1,04 16,34 No P35802 Gpm6a glycoprotein m6a 2 1,04 2 0,99 3 0,98 25,47 No P38647 Hspa9 heat shock protein 9 4 1,12 4 1,08 5 1,13 18,24 No P39053 Dnm1 dynamin 1 4 1,17 4 1,09 5 1,12 29,86 No P40124 Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 3 1,15 2 1,16 3 1,15 14,58 No P40142 Tkt transketolase 4 1,14 4 1,03 5 1,01 20,07 No P40240 Cd9 CD9 antigen 4 0,94 4 1,14 5 0,95 29,22 No P42125 Eci1 enoyl-Coenzyme A delta isomerase 1 2 1,11 3 1,06 2 1,09 13,42 No P43006 Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), 4 1,11 4 0,98 5 1,01 28,19 No member 2 P46460 Nsf N-ethylmaleimide sensitive fusion protein 4 1,09 4 1,05 5 1,04 24,50 No P46660 Ina internexin neuronal intermediate filament protein, alpha 4 1,18 4 1,15 5 1,07 16,86 No P46664 Adss adenylosuccinate synthetase, non muscle 2 1,05 2 1,12 3 1,09 10,53 No P47738 Aldh2 aldehyde dehydrogenase 2, mitochondrial 4 1,16 4 1,09 5 1,06 19,18 No P48036 Anxa5 annexin A5 3 1,17 4 1,16 4 1,13 17,40 No P48722 Hspa4l heat shock protein 4 like 4 1,16 4 1,10 5 1,13 25,01 No P48774 Gstm5 glutathione S-transferase, mu 5 4 1,20 4 1,07 5 1,00 25,80 No P48962 Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide 2 0,97 3 1,18 3 1,12 24,72 No translocator), member 4 P50114 S100b S100 protein, beta polypeptide, neural 4 0,86 4 0,95 5 1,01 28,70 No P50396 Gdi1 guanosine diphosphate (GDP) dissociation inhibitor 1 4 1,10 4 1,01 5 1,03 22,99 No P50516 Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 4 1,08 4 1,01 5 1,04 26,09 No P50518 Atp6v1e1 ATPase, H+ transporting, lysosomal V1 subunit E1 4 1,07 4 1,12 5 1,06 24,49 No P51174 Acadl acyl-Coenzyme A dehydrogenase, long-chain 2 1,11 2 0,93 3 0,94 15,64 No P52480 Pkm pyruvate kinase, muscle 4 1,08 4 1,11 5 1,05 21,79 No P54071 Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 4 1,07 4 1,01 5 0,96 13,40 No P54728 Rad23b RAD23b homolog (S. cerevisiae) 2 1,06 2 1,05 2 1,00 23,86 No P56391 Cox6b1 cytochrome c oxidase, subunit VIb polypeptide 1 4 1,13 4 1,02 5 0,98 15,31 No P56399 Usp5 ubiquitin specific peptidase 5 (isopeptidase T) 4 1,14 4 1,08 5 1,06 20,05 No P56480 Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 4 1,10 4 1,07 5 1,11 31,27 No P58252 Eef2 eukaryotic translation elongation factor 2 4 1,13 4 1,02 5 1,06 30,45 No P58281 Opa1 optic atrophy 1 4 1,08 4 1,06 5 1,00 18,12 No P58389 Ppp2r4 protein phosphatase 2A activator, regulatory subunit B 4 1,06 4 1,03 5 0,94 18,21 No P60202 Plp1 proteolipid protein (myelin) 1 4 1,08 4 1,14 5 0,94 16,71 No P60710 Actb actin, beta 4 1,12 4 1,08 5 1,06 24,25 No P60766 Cdc42 cell division cycle 42 2 1,20 3 1,14 3 1,19 12,73 No P61027 Rab10 RAB10, member RAS oncogene family 4 1,03 4 1,06 5 1,14 31,73 No P61089 Ube2n ubiquitin-conjugating enzyme E2N 2 1,00 2 1,13 3 1,14 12,03 No P61161 Actr2 ARP2 actin-related protein 2 4 1,13 4 0,97 5 1,04 16,00 No P61922 Abat 4-aminobutyrate aminotransferase 4 1,10 4 1,13 5 1,11 19,82 No P61982 Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation 4 1,08 4 1,12 5 1,14 23,38 No protein, gamma polypeptide P62082 Rps7 ribosomal protein S7 4 0,97 4 1,07 5 1,04 28,80 No P62196 Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 2 1,14 3 1,19 3 1,18 25,21 No P62259 Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation 4 1,08 4 1,06 5 1,10 27,45 No protein, epsilon polypeptide P62702 Rps4x ribosomal protein S4, X-linked 2 1,13 2 1,12 3 1,08 18,14 No P62746 Rhob ras homolog gene family, member B 2 1,07 3 1,11 3 1,08 13,81 No P62814 Atp6v1b2 ATPase, H+ transporting, lysosomal V1 subunit B2 4 1,20 4 1,08 5 1,09 20,03 No P62821 Rab1 RAB1, member RAS oncogene family 4 1,01 4 1,16 5 1,03 22,81 No P62835 Rap1a RAS-related protein-1a 4 1,17 3 1,11 4 0,98 25,06 No P62874 Gnb1 guanine nucleotide binding protein (G protein), beta 1 2 1,13 3 1,14 3 1,16 24,11 No P62897 Cycs cytochrome c, somatic 4 0,97 4 0,92 5 1,00 25,08 No P62962 Pfn1 profilin 1 4 1,01 4 0,99 5 1,02 17,53 No P63011 Rab3a RAB3A, member RAS oncogene family 2 1,08 3 1,13 3 1,07 22,74 No P63038 Hspd1 heat shock protein 1 (chaperonin) 4 1,14 4 1,00 5 1,11 27,21 No P63101 Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation 4 1,07 4 1,09 5 1,07 29,30 No protein, zeta polypeptide P63328 Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform 4 1,14 4 1,01 5 1,07 27,88 No P67778 Phb prohibitin 4 1,04 4 1,08 5 1,10 18,96 No P68254 Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation 4 1,19 4 1,11 5 1,12 24,35 No protein, theta polypeptide P68369 Tuba1a tubulin, alpha 1A 4 1,16 4 1,13 5 1,02 22,61 No P68510 Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation 4 1,06 4 1,11 5 1,08 18,41 No protein, eta polypeptide P70168 Kpnb1 karyopherin (importin) beta 1 4 1,04 4 1,10 5 1,01 15,80 No P70336 Rock2 Rho-associated coiled-coil containing protein kinase 2 2 1,15 3 1,19 3 1,18 22,25 No P70398 Usp9x ubiquitin specific peptidase 9, X chromosome 3 1,01 4 1,07 4 1,11 27,43 No P70414 Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 4 1,15 4 1,18 5 1,10 16,48 No P80313 Cct7 chaperonin containing Tcp1, subunit 7 (eta) 3 1,16 3 1,02 4 1,09 18,50 No P80314 Cct2 chaperonin containing Tcp1, subunit 2 (beta) 4 1,08 4 1,09 5 1,08 21,45 No P80315 Cct4 chaperonin containing Tcp1, subunit 4 (delta) 3 1,13 4 1,06 4 1,18 17,46 No P80316 Cct5 chaperonin containing Tcp1, subunit 5 (epsilon) 4 1,07 4 1,04 5 1,09 15,61 No P80317 Cct6a chaperonin containing Tcp1, subunit 6a (zeta) 2 1,13 2 1,07 3 1,03 17,02 No P84075 Hpca hippocalcin 3 0,96 3 1,16 4 1,15 18,84 No P84091 Ap2m1 adaptor-related protein complex 2, mu 1 subunit 4 1,09 4 1,08 5 1,02 21,79 No P97351 Rps3a1 ribosomal protein S3A1 2 1,10 2 1,02 3 0,97 14,71 No P97427 Crmp1 collapsin response mediator protein 1 4 1,08 4 0,96 5 0,96 27,30 No P97807 Fh1 fumarate hydratase 1 4 1,08 4 1,00 5 1,09 24,81 No P99024 Tubb5 tubulin, beta 5 class I 4 0,97 4 1,15 5 1,10 20,42 No P99027 Rplp2 ribosomal protein, large P2 2 1,14 3 1,06 3 1,13 14,49 No P99028 Uqcrh ubiquinol-cytochrome c reductase hinge protein 4 1,12 4 1,04 5 1,05 15,24 No P99029 Prdx5 peroxiredoxin 5 4 1,16 4 1,15 5 1,11 19,70 No Q00612 G6pdx glucose-6-phosphate dehydrogenase X-linked 3 0,92 3 1,09 4 0,98 31,42 No Q01853 Vcp valosin containing protein 4 1,05 4 1,05 5 1,06 20,82 No Q02053 Uba1 ubiquitin-like modifier activating enzyme 1 4 1,14 4 1,05 5 1,02 19,53 No Q03265 Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 4 1,07 4 1,15 5 1,12 20,43 No 1 Q04447 Ckb creatine kinase, brain 4 1,15 4 1,11 5 1,06 29,01 No Q05920 Pcx pyruvate carboxylase 4 1,19 4 1,11 5 1,06 21,75 No Q06138 Cab39 calcium binding protein 39 4 1,19 4 1,14 5 1,09 17,30 No Q08331 Calb2 calbindin 2 4 1,08 4 1,18 5 0,99 22,99 No Q0KL02 Trio triple functional domain (PTPRF interacting) 2 1,13 3 1,08 4 0,92 19,01 No Q11011 Npepps aminopeptidase puromycin sensitive 4 1,03 4 1,04 5 1,03 20,44 No Q3TXS7 Psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 2 1,16 2 1,10 3 0,95 20,23 No Q3UHB1 Nt5dc3 5'-nucleotidase domain containing 3 4 1,18 4 1,04 5 1,14 15,65 No Q3UHJ0 Aak1 AP2 associated kinase 1 3 1,11 4 1,15 5 1,01 18,64 No Q3UMR5 Mcu mitochondrial calcium uniporter 3 1,05 3 1,11 4 1,11 19,70 No Q3UPL0 Sec31a Sec31 homolog A (S. cerevisiae) 2 1,13 2 1,01 3 0,97 20,57 No Q4KMM3 Oxr1 oxidation resistance 1 2 1,12 3 1,01 3 1,15 16,00 No Q5DTL9 Slc4a10 solute carrier family 4, sodium bicarbonate cotransporter-like, member 2 1,13 2 1,03 3 1,00 23,58 No 10 Q5PR73 Diras2 DIRAS family, GTP-binding RAS-like 2 4 1,15 4 1,11 5 1,05 14,88 No Q5U458 Dnajc11 DnaJ (Hsp40) homolog, subfamily C, member 11 3 1,16 4 1,11 4 1,11 21,88 No Q60597 Ogdh oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 4 1,12 4 1,08 5 1,04 24,00 No Q60864 Stip1 stress-induced phosphoprotein 1 4 1,10 4 1,05 5 1,13 11,74 No Q60932 Vdac1 voltage-dependent anion channel 1 4 1,17 4 1,05 5 1,10 19,52 No Q60996 Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma 4 1,03 4 1,05 5 1,16 22,49 No Q61166 Mapre1 microtubule-associated protein, RP/EB family, member 1 3 1,06 2 1,20 3 1,13 15,01 No Q61171 Prdx2 peroxiredoxin 2 4 1,15 4 1,00 5 1,14 24,46 No Q61206 Pafah1b2 platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 4 1,03 4 1,07 5 1,06 18,70 No Q61316 Hspa4 heat shock protein 4 4 1,11 4 1,10 5 1,11 20,41 No Q61553 Fscn1 fascin homolog 1, actin bundling protein (Strongylocentrotus 3 1,15 4 1,12 4 1,17 14,69 No purpuratus) Q61598 Gdi2 guanosine diphosphate (GDP) dissociation inhibitor 2 4 1,13 4 1,05 5 1,07 27,04 No Q61699 Hsph1 heat shock 105kDa/110kDa protein 1 4 1,09 4 1,15 5 1,12 19,35 No Q61753 Phgdh 3-phosphoglycerate dehydrogenase 2 1,03 3 0,99 3 1,12 16,89 No Q61879 Myh10 myosin, heavy polypeptide 10, non-muscle 4 1,17 4 1,03 5 1,01 24,71 No Q62167 Ddx3x DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked 3 1,12 3 1,08 4 1,09 11,32 No Q62261 Sptbn1 spectrin beta, non-erythrocytic 1 4 1,16 4 1,07 5 1,04 21,46 No Q62420 Sh3gl2 SH3-domain GRB2-like 2 3 1,04 4 1,01 4 1,17 18,29 No Q62433 Ndrg1 N-myc downstream regulated gene 1 2 1,05 3 0,96 3 1,16 23,90 No Q62443 Nptx1 neuronal pentraxin 1 3 1,08 3 1,11 3 1,02 20,70 No Q63810 Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin 4 1,15 4 1,06 5 1,09 28,44 No B, type I) Q641P0 Actr3b ARP3 actin-related protein 3B 2 1,01 2 1,01 2 0,82 13,06 No Q64332 Syn2 synapsin II 4 1,09 4 1,00 5 1,08 27,94 No Q64521 Gpd2 glycerol phosphate dehydrogenase 2, mitochondrial 4 1,01 4 1,01 5 1,00 28,29 No Q68FD5 Cltc clathrin, heavy polypeptide (Hc) 4 1,14 4 1,07 5 1,06 27,32 No Q6A4J8 Usp7 ubiquitin specific peptidase 7 3 1,10 3 0,89 4 0,90 23,15 No Q6NXK7 Dpp10 dipeptidylpeptidase 10 3 1,06 3 1,19 4 1,03 22,76 No Q6NZJ6 Eif4g1 eukaryotic translation initiation factor 4, gamma 1 2 1,01 3 1,00 3 1,05 8,62 No Q6P5F9 Xpo1 exportin 1, CRM1 homolog (yeast) 3 0,93 3 1,06 4 1,04 29,58 No Q6PGN3 Dclk2 doublecortin-like kinase 2 3 1,03 3 0,92 4 1,00 20,95 No Q6PIC6 Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 4 1,06 4 1,14 5 1,08 26,47 No Q6PIE5 Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 4 0,84 4 1,06 4 1,02 27,83 No Q6ZPE2 Sbf1 SET binding factor 1 3 1,00 3 1,08 4 0,94 30,71 No Q6ZQ38 Cand1 cullin associated and neddylation disassociated 1 4 1,07 4 1,08 5 1,04 19,55 No Q76MZ3 Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha 4 1,13 4 1,06 5 1,09 26,52 No Q78ZA7 Nap1l4 nucleosome assembly protein 1-like 4 2 0,99 3 1,01 2 1,00 14,22 No Q7TQF7 Amph amphiphysin 4 1,15 4 1,05 5 1,17 22,72 No Q7TSJ2 Map6 microtubule-associated protein 6 4 1,12 4 1,15 4 1,09 20,28 No Q80TL0 Ppm1e protein phosphatase 1E (PP2C domain containing) 2 1,04 2 1,15 3 0,92 16,85 No Q80TL4 N28178 expressed sequence N28178 3 1,12 3 1,07 4 1,04 16,62 No Q80TZ3 Dnajc6 DnaJ (Hsp40) homolog, subfamily C, member 6 4 1,13 4 1,15 5 1,11 16,40 No Q80UG2 Plxna4 plexin A4 3 1,00 3 1,12 4 1,14 16,60 No Q810U3 Nfasc neurofascin 2 1,17 3 1,18 3 1,14 20,71 No Q810U4 Nrcam neuronal cell adhesion molecule 4 1,11 4 1,05 5 1,06 16,20 No Q8BH44 Coro2b coronin, actin binding protein, 2B 3 0,99 2 1,15 4 0,98 10,94 No Q8BHN3 Ganab alpha glucosidase 2 alpha neutral subunit 2 1,14 2 1,03 3 1,05 21,22 No Q8BMF3 Me3 malic enzyme 3, NADP(+)-dependent, mitochondrial 3 1,07 3 1,03 3 1,01 31,81 No Q8BMS1 Hadha hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A 4 1,12 4 1,15 5 1,13 25,97 No thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit Q8BNY6 Ncs1 neuronal calcium sensor 1 4 1,08 4 1,06 5 1,04 15,84 No Q8BPN8 Dmxl2 Dmx-like 2 4 1,05 4 0,99 4 1,11 32,03 No Q8BRT1 Clasp2 CLIP associating protein 2 4 1,06 4 1,12 5 1,12 17,68 No Q8BVE3 Atp6v1h ATPase, H+ transporting, lysosomal V1 subunit H 4 1,05 4 1,14 5 1,13 24,05 No Q8BWF0 Aldh5a1 aldhehyde dehydrogenase family 5, subfamily A1 3 1,08 3 1,01 5 1,13 27,26 No Q8BWG8 Arrb1 arrestin, beta 1 2 1,04 2 1,12 3 1,07 18,31 No Q8BYI9 Tnr tenascin R 4 1,08 4 1,03 5 1,00 18,56 No Q8C1A5 Thop1 thimet oligopeptidase 1 2 1,02 3 1,01 2 1,17 10,21 No Q8C8R3 Ank2 ankyrin 2, brain 4 1,17 4 1,13 5 1,12 25,46 No Q8CAA7 Pgm2l1 phosphoglucomutase 2-like 1 3 1,16 3 1,16 4 1,17 17,09 No Q8CAQ8 Immt inner membrane protein, mitochondrial 4 1,06 3 1,17 5 1,06 18,96 No Q8CBW3 Abi1 abl-interactor 1 2 1,18 2 1,09 3 0,96 35,06 No Q8CG76 Akr7a5 aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase) 3 1,07 4 1,05 4 1,16 20,56 No Q8CGY8 Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N- 3 1,15 4 1,12 5 1,07 28,18 No acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) Q8CHC4 Synj1 synaptojanin 1 4 1,16 4 1,14 5 1,11 18,34 No Q8CHG7 Rapgef2 Rap guanine nucleotide exchange factor (GEF) 2 4 1,11 4 1,11 5 1,08 14,07 No Q8CI94 Pygb brain glycogen phosphorylase 4 1,14 4 0,98 5 0,97 20,60 No Q8K0U4 Hspa12a heat shock protein 12A 4 1,05 4 1,02 5 1,03 22,50 No Q8K183 Pdxk pyridoxal (pyridoxine, vitamin B6) kinase 4 1,15 4 1,07 5 1,15 18,99 No Q8K2B3 Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 4 1,11 4 1,14 5 1,15 20,98 No Q8K2C9 Ptplad1 protein tyrosine phosphatase-like A domain containing 1 4 1,16 4 1,12 5 1,06 24,80 No Q8K310 Matr3 matrin 3 4 1,09 4 0,89 5 0,95 16,24 No Q8K3J1 Ndufs8 NADH dehydrogenase (ubiquinone) Fe-S protein 8 4 1,01 4 1,11 5 1,11 22,93 No Q8R001 Mapre2 microtubule-associated protein, RP/EB family, member 2 4 1,05 4 1,20 5 1,08 28,83 No Q8R081 Hnrnpl heterogeneous nuclear ribonucleoprotein L 3 1,02 4 1,01 4 1,14 21,02 No Q8R0Y6 Aldh1l1 aldehyde dehydrogenase 1 family, member L1 4 1,10 4 1,12 5 1,07 21,89 No Q8R574 Prpsap2 phosphoribosyl pyrophosphate synthetase-associated protein 2 3 1,05 3 0,97 4 1,05 16,14 No Q8R5C5 Actr1b ARP1 actin-related protein 1B, centractin beta 2 1,02 2 0,91 3 0,93 21,36 No Q8R5H6 Wasf1 WAS protein family, member 1 4 1,08 4 1,02 5 1,05 19,22 No Q8VDR9 Dock6 dedicator of cytokinesis 6 2 0,95 2 0,95 2 1,06 12,96 No Q8VEH3 Arl8a ADP-ribosylation factor-like 8A 4 1,07 4 1,15 5 1,06 28,46 No Q8VEK3 Hnrnpu heterogeneous nuclear ribonucleoprotein U 3 1,12 4 1,02 4 1,09 10,24 No Q8VEM8 Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), 4 1,19 4 1,16 4 1,11 21,91 No member 3 Q8VIJ6 Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding 4 1,08 4 1,08 4 1,05 19,16 No protein associated) Q91V12 Acot7 acyl-CoA thioesterase 7 4 1,13 4 1,09 4 1,13 18,61 No Q91V14 Slc12a5 solute carrier family 12, member 5 3 1,14 3 1,09 4 1,03 20,79 No Q91V92 Acly ATP citrate lyase 2 1,06 3 1,14 3 1,14 23,28 No Q91VR5 Ddx1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 3 1,02 3 0,97 3 1,15 16,60 No Q91WC3 Acsl6 acyl-CoA synthetase long-chain family member 6 4 1,03 4 1,18 5 1,06 24,81 No Q91X97 Ncald neurocalcin delta 4 1,19 4 1,10 5 1,11 32,77 No Q91XM9 Dlg2 discs, large homolog 2 (Drosophila) 2 0,99 3 1,06 3 1,18 15,59 No Q91YT0 Ndufv1 NADH dehydrogenase (ubiquinone) flavoprotein 1 4 1,11 4 1,09 5 1,08 20,85 No Q91ZJ5 Ugp2 UDP-glucose pyrophosphorylase 2 4 1,01 4 1,06 5 1,03 16,96 No Q91ZZ3 Sncb synuclein, beta 2 1,08 3 1,01 3 1,11 22,49 No Q920I9 Wdr7 WD repeat domain 7 3 1,07 4 1,02 4 1,06 19,96 No Q920P5 Ak5 adenylate kinase 5 3 1,15 2 1,07 3 1,03 18,10 No Q922F4 Tubb6 tubulin, beta 6 class V 4 1,07 4 1,16 4 1,11 39,56 No Q93092 Taldo1 transaldolase 1 2 1,15 2 1,16 3 1,00 10,01 No Q99020 Hnrnpab heterogeneous nuclear ribonucleoprotein A/B 3 1,10 3 0,99 4 0,95 13,35 No Q99104 Myo5a myosin VA 4 1,12 4 1,01 5 0,92 22,84 No Q99KH8 Stk24 serine/threonine kinase 24 3 1,11 3 0,93 3 1,17 20,47 No Q99KI0 Aco2 aconitase 2, mitochondrial 4 1,09 4 1,05 5 1,08 36,00 No Q99KJ8 Dctn2 dynactin 2 3 1,01 4 1,06 4 1,13 10,92 No Q99L13 Hibadh 3-hydroxyisobutyrate dehydrogenase 3 1,09 4 1,05 4 1,12 20,52 No Q99L43 Cds2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 4 1,16 4 1,15 5 1,08 25,69 No Q99LC5 Etfa electron transferring flavoprotein, alpha polypeptide 4 1,06 4 1,06 5 1,16 23,94 No Q99LD4 Gps1 G protein pathway suppressor 1 2 1,20 2 1,13 3 1,08 11,61 No Q99LT0 Dpy30 dpy-30 homolog (C. elegans) 2 1,09 2 1,03 2 1,10 9,23 No Q99LX0 Park7 Parkinson disease (autosomal recessive, early onset) 7 3 1,19 3 1,04 4 1,09 24,64 No Q99MN9 Pccb propionyl Coenzyme A carboxylase, beta polypeptide 3 1,03 3 1,01 4 1,02 14,66 No Q9CPY7 Lap3 leucine aminopeptidase 3 4 1,14 4 1,11 5 1,09 16,31 No Q9CQE8 2700060E02Rik RIKEN cDNA 2700060E02 gene 3 1,14 3 1,00 3 1,12 32,33 No Q9CQI3 Gmfb glia maturation factor, beta 2 1,09 2 1,18 3 1,18 14,54 No Q9CQV8 Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation 4 1,02 4 1,13 5 1,11 16,09 No protein, beta polypeptide Q9CVB6 Arpc2 actin related protein 2/3 complex, subunit 2 4 1,09 4 1,06 5 1,06 22,33 No Q9CWJ9 Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP 2 1,16 3 1,11 3 1,16 10,62 No cyclohydrolase Q9CZ30 Ola1 Obg-like ATPase 1 4 1,10 4 1,05 5 1,07 19,78 No Q9CZC8 Scrn1 secernin 1 4 1,03 4 1,03 5 1,03 18,49 No Q9CZD3 Gars glycyl-tRNA synthetase 4 1,08 4 1,04 5 1,07 13,50 No Q9CZU6 Cs citrate synthase 4 1,10 4 1,01 5 1,05 26,46 No Q9D0K2 Oxct1 3-oxoacid CoA transferase 1 4 1,13 4 0,95 5 1,10 33,39 No Q9D5V5 Cul5 cullin 5 2 1,06 3 1,08 3 1,16 25,88 No Q9D6F9 Tubb4a tubulin, beta 4A class IVA 4 1,06 4 1,16 5 1,15 25,17 No Q9D6J6 Ndufv2 NADH dehydrogenase (ubiquinone) flavoprotein 2 2 1,13 2 1,07 3 1,04 16,92 No Q9DB20 Atp5o ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 4 0,93 4 1,11 5 1,04 20,61 No Q9DBG3 Ap2b1 adaptor-related protein complex 2, beta 1 subunit 4 1,08 4 1,19 5 1,01 30,49 No Q9DBG6 Rpn2 ribophorin II 3 1,06 2 1,16 4 1,07 18,89 No Q9DBJ1 Pgam1 phosphoglycerate mutase 1 4 1,10 4 1,16 5 1,08 19,94 No Q9DBP5 Cmpk1 cytidine monophosphate (UMP-CMP) kinase 1 3 1,17 3 1,13 4 1,03 27,82 No Q9DC69 Ndufa9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 4 1,08 4 1,11 5 1,13 22,25 No Q9DCJ5 Ndufa8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8 3 1,07 4 1,15 4 1,15 13,35 No Q9DCL9 Paics phosphoribosylaminoimidazole carboxylase, 4 0,99 4 1,14 5 1,03 20,70 No phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase Q9DCS9 Ndufb10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10 4 1,10 3 1,13 5 1,15 21,74 No Q9DCT2 Ndufs3 NADH dehydrogenase (ubiquinone) Fe-S protein 3 4 1,18 4 1,13 5 1,09 21,81 No Q9DCX2 Atp5h ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D 4 1,19 4 1,18 5 1,15 29,35 No Q9EPN1 Nbea neurobeachin 4 1,07 4 1,04 4 0,98 17,43 No Q9EQH3 Vps35 vacuolar protein sorting 35 4 0,97 4 1,09 5 1,03 21,63 No Q9ERD7 Tubb3 tubulin, beta 3 class III 4 1,10 4 0,99 5 1,01 29,70 No Q9ERK4 Cse1l chromosome segregation 1-like (S. cerevisiae) 3 1,12 3 1,09 4 1,11 19,28 No Q9ES97 Rtn3 reticulon 3 2 0,97 3 1,07 3 1,05 15,75 No Q9JHU4 Dync1h1 dynein cytoplasmic 1 heavy chain 1 4 1,14 4 1,10 5 1,06 27,65 No Q9JHU9 Isyna1 myo-inositol 1-phosphate synthase A1 2 1,09 3 1,14 3 1,15 15,75 No Q9JIS5 Sv2a synaptic vesicle glycoprotein 2 a 3 1,04 3 1,15 4 1,11 15,97 No Q9JJK2 Lancl2 LanC (bacterial lantibiotic synthetase component C)-like 2 4 1,16 4 1,08 5 1,08 11,99 No Q9JJV2 Pfn2 profilin 2 2 1,19 2 1,17 3 1,19 20,97 No Q9JKD3 Scamp5 secretory carrier membrane protein 5 2 0,96 3 1,00 3 1,05 24,80 No Q9JKK7 Tmod2 tropomodulin 2 2 1,02 2 1,07 3 1,05 18,10 No Q9JLN9 Mtor mechanistic target of rapamycin (serine/threonine kinase) 2 1,17 2 1,13 2 1,06 27,45 No Q9JLV5 Cul3 cullin 3 4 1,07 4 1,12 5 1,13 12,66 No Q9JM76 Arpc3 actin related protein 2/3 complex, subunit 3 4 1,16 4 1,03 5 1,01 22,43 No Q9QUM9 Psma6 proteasome (prosome, macropain) subunit, alpha type 6 2 0,99 3 1,03 3 1,14 18,06 No Q9QVP9 Ptk2b PTK2 protein tyrosine kinase 2 beta 4 1,12 4 1,06 5 1,09 19,52 No Q9QXS1 Plec plectin 4 1,15 4 1,08 5 1,08 14,92 No Q9QXZ0 Macf1 microtubule-actin crosslinking factor 1 4 1,08 4 1,01 5 1,00 18,96 No Q9QYB1 Clic4 chloride intracellular channel 4 (mitochondrial) 4 1,07 4 1,10 5 1,12 16,55 No Q9QYG0 Ndrg2 N-myc downstream regulated gene 2 4 1,08 4 1,16 4 1,16 24,18 No Q9QYR6 Map1a microtubule-associated protein 1 A 4 1,11 4 1,06 5 1,11 19,80 No Q9QZX7 Srr serine racemase 4 1,19 4 1,00 3 1,17 27,88 No Q9R0Y5 Ak1 adenylate kinase 1 4 1,07 4 1,07 5 1,18 20,51 No Q9R111 Gda guanine deaminase 2 1,05 2 1,03 3 1,12 20,13 No Q9R1P4 Psma1 proteasome (prosome, macropain) subunit, alpha type 1 2 1,15 3 0,98 3 1,16 18,07 No Q9R1T4 Sept6 septin 6 2 1,13 3 1,13 3 1,13 21,93 No Q9WTT4 Atp6v1g2 ATPase, H+ transporting, lysosomal V1 subunit G2 4 1,01 4 0,99 5 1,01 24,07 No Q9WUL7 Arl3 ADP-ribosylation factor-like 3 3 1,14 3 1,13 4 1,03 13,22 No Q9WUM5 Suclg1 succinate-CoA ligase, GDP-forming, alpha subunit 2 1,08 3 1,08 3 1,17 14,52 No Q9Z0E0 Ncdn neurochondrin 4 1,12 4 1,10 5 1,13 22,96 No Q9Z0P5 Twf2 twinfilin, actin-binding protein, homolog 2 (Drosophila) 3 1,16 3 1,14 4 1,05 27,75 No Q9Z140 Cpne6 copine VI 4 1,16 4 1,05 5 1,04 20,42 No Q9Z1G3 Atp6v1c1 ATPase, H+ transporting, lysosomal V1 subunit C1 4 1,04 4 1,04 5 1,03 19,75 No Q9Z268 Rasal1 RAS protein activator like 1 (GAP1 like) 3 1,12 3 1,15 4 1,10 11,25 No Q9Z2Q6 Sept5 septin 5 3 1,00 3 1,06 4 1,05 17,84 No Q9Z2U1 Psma5 proteasome (prosome, macropain) subunit, alpha type 5 4 1,00 4 0,94 3 1,03 19,88 No Q9Z2W9 Gria3 glutamate receptor, ionotropic, AMPA3 (alpha 3) 3 1,16 3 1,15 3 1,07 22,57 No A2AG50 Map7d2 MAP7 domain containing 2 2 0,96 2 1,18 2 1,26 37,07 (Dp-Tg) O55042 Snca synuclein, alpha 3 1,16 4 1,15 4 1,51 18,57 (Dp-Tg) P07724 Alb albumin 4 1,08 4 1,17 5 1,23 23,16 (Dp-Tg) P0C7L0 Wipf3 WAS/WASL interacting protein family, member 3 2 0,94 3 1,13 3 1,20 30,09 (Dp-Tg) P13707 Gpd1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3 1,13 4 1,16 4 1,25 14,78 (Dp-Tg) P28271 Aco1 aconitase 1 2 1,08 3 1,16 3 1,22 11,46 (Dp-Tg) P28352 Apex1 apurinic/apyrimidinic endonuclease 1 2 1,07 3 0,89 3 1,20 29,95 (Dp-Tg) P28738 Kif5c kinesin family member 5C 3 1,10 4 1,14 4 1,21 18,08 (Dp-Tg) P33173 Kif1a kinesin family member 1A 2 0,97 3 1,18 3 1,23 18,53 (Dp-Tg) P47708 Rph3a rabphilin 3A 2 1,16 3 1,16 3 1,23 30,29 (Dp-Tg) P59764 Dock4 dedicator of cytokinesis 4 2 1,16 2 1,19 2 1,27 17,40 (Dp-Tg) P61264 Stx1b syntaxin 1B 3 1,10 4 1,19 4 1,22 21,31 (Dp-Tg) P62482 Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta 3 1,05 4 1,11 4 1,22 34,52 (Dp-Tg) member 2 P62631 Eef1a2 eukaryotic translation elongation factor 1 alpha 2 2 1,07 3 1,02 2 1,25 33,26 (Dp-Tg) P63040 Cplx1 complexin 1 2 1,08 3 1,14 3 1,40 18,25 (Dp-Tg) P68037 Ube2l3 ubiquitin-conjugating enzyme E2L 3 3 1,08 2 1,02 2 1,24 30,14 (Dp-Tg) Q3UNH4 Gprin1 G protein-regulated inducer of neurite outgrowth 1 4 1,19 4 1,14 5 1,25 14,44 (Dp-Tg) Q60605 Myl6 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle 4 1,18 4 1,02 5 1,22 19,09 (Dp-Tg) Q61207 Psap prosaposin 2 1,07 3 1,10 3 1,27 29,79 (Dp-Tg) Q64737 Gart phosphoribosylglycinamide formyltransferase 3 1,16 4 1,12 4 1,22 15,59 (Dp-Tg) Q80TM9 Nisch nischarin 2 1,13 3 1,00 3 1,27 23,54 (Dp-Tg) Q8BGH2 Samm50 sorting and assembly machinery component 50 homolog (S. cerevisiae) 3 1,07 4 1,12 4 1,26 12,42 (Dp-Tg) Q8BGQ7 Aars alanyl-tRNA synthetase 2 1,01 2 1,18 2 1,32 15,30 (Dp-Tg) Q8C0M9 Asrgl1 asparaginase like 1 2 1,09 3 1,05 3 1,20 18,95 (Dp-Tg) Q8R1Q8 Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 2 1,17 2 1,09 2 1,29 23,41 (Dp-Tg) Q8R3V5 Sh3glb2 SH3-domain GRB2-like endophilin B2 2 1,12 3 1,15 3 1,23 16,43 (Dp-Tg) Q91VM9 Ppa2 pyrophosphatase (inorganic) 2 2 1,18 2 1,08 3 1,25 25,78 (Dp-Tg) Q921I1 Trf transferrin 4 1,18 4 1,19 4 1,42 19,94 (Dp-Tg) Q922S4 Pde2a phosphodiesterase 2A, cGMP-stimulated 2 1,11 3 1,01 2 1,20 21,00 (Dp-Tg) Q99P72 Rtn4 reticulon 4 3 1,02 3 1,09 4 1,28 25,09 (Dp-Tg) Q9CWS0 Ddah1 dimethylarginine dimethylaminohydrolase 1 2 1,07 3 1,11 3 1,31 15,20 (Dp-Tg) Q9D1A2 Cndp2 CNDP dipeptidase 2 (metallopeptidase M20 family) 3 1,09 3 1,00 4 1,32 31,52 (Dp-Tg) Q9D6R2 Idh3a isocitrate dehydrogenase 3 (NAD+) alpha 2 1,04 3 1,09 3 1,21 17,76 (Dp-Tg) Q9DCD0 Pgd phosphogluconate dehydrogenase 2 1,17 2 1,08 2 1,28 13,74 (Dp-Tg) Q9JII6 Akr1a1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 4 1,10 4 1,10 4 1,22 18,90 (Dp-Tg) Q9JMH9 Myo18a myosin XVIIIA 2 1,13 3 1,09 3 1,25 14,15 (Dp-Tg) Q9QYC0 Add1 adducin 1 (alpha) 3 1,02 3 1,17 3 1,31 29,23 (Dp-Tg) Q9WV92 Epb4.1l3 erythrocyte protein band 4.1-like 3 2 1,10 3 1,16 3 1,36 17,50 (Dp-Tg) O35526 Stx1a syntaxin 1A (brain) 2 1,07 3 1,22 3 0,96 24,44 Tg O35678 Mgll monoglyceride lipase 4 1,19 4 1,23 5 1,12 17,71 Tg P09671 Sod2 superoxide dismutase 2, mitochondrial 4 1,11 4 1,24 5 1,14 16,86 Tg P23818 Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) 2 1,19 2 1,22 3 1,09 27,48 Tg P25444 Rps2 ribosomal protein S2 2 1,17 2 1,21 3 1,08 14,45 Tg P28474 Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide 3 1,18 3 1,34 2 1,19 8,37 Tg P31938 Map2k1 mitogen-activated protein kinase kinase 1 4 1,03 4 1,22 5 1,05 20,49 Tg P49722 Psma2 proteasome (prosome, macropain) subunit, alpha type 2 3 0,94 4 1,20 5 0,94 17,60 Tg P56565 S100a1 S100 calcium binding protein A1 3 1,08 2 1,32 4 1,14 18,20 Tg P62823 Rab3c RAB3C, member RAS oncogene family 4 1,15 4 1,22 5 1,17 17,14 Tg Q61885 Mog myelin oligodendrocyte glycoprotein 3 1,15 2 1,24 4 0,95 20,49 Tg Q8CGC7 Eprs glutamyl-prolyl-tRNA synthetase 4 1,20 4 1,28 5 1,14 20,40 Tg Q8CHH9 Sept8 septin 8 4 1,17 4 1,34 4 1,12 26,55 Tg Q8VDQ8 Sirt2 sirtuin 2 2 1,13 3 1,27 3 1,01 19,15 Tg Q9CYT6 Cap2 CAP, adenylate cyclase-associated protein, 2 (yeast) 2 1,02 2 1,30 3 1,04 19,39 Tg Q9CZT8 Rab3b RAB3B, member RAS oncogene family 4 1,15 4 1,20 5 1,16 29,09 Tg Q9D051 Pdhb pyruvate dehydrogenase (lipoamide) beta 2 1,15 3 1,26 3 1,12 27,23 Tg Q9D172 D10Jhu81e DNA segment, Chr 10, Johns Hopkins University 81 expressed 2 1,16 2 1,21 3 1,20 13,92 Tg Q9WUR9 Ak4 adenylate kinase 4 2 1,06 3 1,20 4 1,13 28,13 Tg Q8BLK3 Lsamp limbic system-associated membrane protein 2 1,05 2 0,68 3 0,82 15,79 Tg P12367 Prkar2a protein kinase, cAMP dependent regulatory, type II alpha 2 1,18 3 1,26 3 1,40 14,87 Tg + (Dp-Tg) P97370 Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2 1,09 3 1,38 3 1,24 36,38 Tg + (Dp-Tg) P98086 C1qa complement component 1, q subcomponent, alpha polypeptide 2 1,07 2 1,24 2 1,63 16,31 Tg + (Dp-Tg) Q6PCP5 Mff mitochondrial fission factor 2 1,15 2 1,42 3 1,36 20,22 Tg + (Dp-Tg) Q8CGK3 Lonp1 lon peptidase 1, mitochondrial 2 1,18 2 1,25 3 1,21 21,43 Tg + (Dp-Tg) Q8VDN2 Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 2 1,15 3 1,20 3 1,27 21,84 Tg + (Dp-Tg) Q9JKR6 Hyou1 hypoxia up-regulated 1 2 1,19 2 1,24 2 1,35 14,45 Tg + (Dp-Tg) Q9Z2I0 Letm1 leucine zipper-EF-hand containing transmembrane protein 1 4 1,12 4 1,31 5 1,24 22,30 Tg + (Dp-Tg) P51863 Atp6v0d1 ATPase, H+ transporting, lysosomal V0 subunit D1 2 0,98 2 0,69 3 0,76 31,29 Tg + (Dp-Tg) B2RSH2 Gnai1 guanine nucleotide binding protein (G protein), alpha inhibiting 1 4 1,22 4 1,05 5 1,03 17,64 Dp E9PUL5 Prrt2 proline-rich transmembrane protein 2 3 1,24 3 1,20 4 1,19 18,16 Dp E9Q401 Ryr2 ryanodine receptor 2, cardiac 4 1,24 3 1,10 5 1,13 27,80 Dp O55022 Pgrmc1 progesterone receptor membrane component 1 2 1,22 3 1,19 3 1,20 22,89 Dp O55125 Nipsnap1 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like 3 1,32 3 1,19 4 1,07 16,14 Dp protein homolog 1 (C. elegans) O70318 Epb4.1l2 erythrocyte protein band 4.1-like 2 2 1,39 2 1,09 3 1,04 20,66 Dp O88343 Slc4a4 solute carrier family 4 (anion exchanger), member 4 4 1,20 4 1,09 5 1,06 16,29 Dp O88737 Bsn bassoon 4 1,20 4 1,03 5 1,04 21,16 Dp O89053 Coro1a coronin, actin binding protein 1A 4 1,33 4 1,08 5 1,18 26,45 Dp P03995 Gfap glial fibrillary acidic protein 3 1,28 3 1,05 4 1,11 18,20 Dp P04370 Mbp myelin basic protein 4 1,21 4 1,14 5 1,03 33,04 Dp P08551 Nefl neurofilament, light polypeptide 4 1,30 4 1,10 5 1,12 15,80 Dp P09405 Ncl nucleolin 3 1,24 2 1,09 4 1,07 12,33 Dp P10605 Ctsb cathepsin B 2 1,31 2 1,12 3 1,13 23,40 Dp P10649 Gstm1 glutathione S-transferase, mu 1 3 1,24 3 1,17 4 1,20 19,39 Dp P10852 Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid 2 1,21 2 1,15 3 1,05 22,72 Dp transport), member 2 P11798 Camk2a calcium/calmodulin-dependent protein kinase II alpha 4 1,43 4 0,99 5 1,06 17,89 Dp P11983 Tcp1 t-complex protein 1 3 1,23 3 1,08 5 1,04 22,70 Dp P14094 Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide 4 1,26 4 1,01 5 1,06 34,14 Dp P16460 Ass1 argininosuccinate synthetase 1 4 1,20 4 1,13 5 1,03 30,27 Dp P20029 Hspa5 heat shock protein 5 4 1,21 4 1,03 5 1,10 24,59 Dp P21107 Tpm3 tropomyosin 3, gamma 2 1,20 2 1,15 3 1,15 16,57 Dp P27773 Pdia3 protein disulfide isomerase associated 3 4 1,25 4 1,16 5 1,16 25,59 Dp P35505 Fah fumarylacetoacetate hydrolase 2 1,25 3 1,10 3 1,06 13,14 Dp P47809 Map2k4 mitogen-activated protein kinase kinase 4 4 1,40 4 1,07 5 1,20 19,52 Dp P47857 Pfkm phosphofructokinase, muscle 4 1,22 4 1,11 5 1,09 23,75 Dp P48453 Ppp3cb protein phosphatase 3, catalytic subunit, beta isoform 3 1,28 3 1,06 4 1,09 14,01 Dp P49442 Inpp1 inositol polyphosphate-1-phosphatase 2 1,22 2 0,95 3 0,97 15,86 Dp P56564 Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), 4 1,23 4 1,08 5 1,04 18,08 Dp member 3 P57746 Atp6v1d ATPase, H+ transporting, lysosomal V1 subunit D 2 1,28 3 1,01 3 1,19 19,42 Dp P57780 Actn4 actinin alpha 4 2 1,86 2 1,06 2 1,07 19,38 Dp P61979 Hnrnpk heterogeneous nuclear ribonucleoprotein K 4 1,20 4 1,03 5 1,03 21,97 Dp P62761 Vsnl1 visinin-like 1 4 1,24 4 1,04 5 1,12 16,13 Dp P62880 Gnb2 guanine nucleotide binding protein (G protein), beta 2 4 1,37 4 0,99 5 1,11 25,73 Dp P63037 Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 2 1,40 3 0,93 4 0,91 24,50 Dp P63318 Prkcg protein kinase C, gamma 4 1,21 4 1,11 5 1,10 28,90 Dp P68368 Tuba4a tubulin, alpha 4A 4 1,20 4 1,19 5 1,11 24,61 Dp P97379 G3bp2 GTPase activating protein (SH3 domain) binding protein 2 2 1,39 3 1,04 3 1,13 17,61 Dp Q06890 Clu clusterin 2 1,27 2 1,11 3 0,98 13,83 Dp Q148V7 2310035C23Rik RIKEN cDNA 2310035C23 gene 2 1,23 3 1,03 2 0,95 20,97 Dp Q3UHL1 Camkv CaM kinase-like vesicle-associated 4 1,27 4 1,05 5 1,09 21,27 Dp Q3UVX5 Grm5 glutamate receptor, metabotropic 5 2 1,27 2 1,09 3 0,97 22,29 Dp Q5FWK3 Arhgap1 Rho GTPase activating protein 1 2 1,35 2 1,12 3 1,17 18,48 Dp Q5SQX6 Cyfip2 cytoplasmic FMR1 interacting protein 2 4 1,22 4 1,15 5 1,10 23,66 Dp Q61361 Bcan brevican 4 1,33 4 1,10 5 1,09 25,36 Dp Q61543 Glg1 golgi apparatus protein 1 2 1,41 2 1,01 3 1,00 14,29 Dp Q61548 Snap91 synaptosomal-associated protein 91 4 1,23 4 1,11 5 1,15 30,92 Dp Q61644 Pacsin1 protein kinase C and casein kinase substrate in neurons 1 3 1,28 3 1,16 4 1,14 18,80 Dp Q61990 Pcbp2 poly(rC) binding protein 2 3 1,21 3 1,10 4 1,15 17,90 Dp Q64010 Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 3 1,39 3 1,11 4 1,13 19,73 Dp Q6ZPJ3 Ube2o ubiquitin-conjugating enzyme E2O 4 1,39 4 1,14 5 1,15 33,20 Dp Q7TMK9 Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein 2 1,21 2 1,12 3 1,04 19,61 Dp Q7TPR4 Actn1 actinin, alpha 1 4 1,22 4 1,05 4 1,07 17,90 Dp Q7TQD2 Tppp tubulin polymerization promoting protein 4 1,21 4 1,07 5 1,10 20,61 Dp Q80TJ1 Cadps Ca2+-dependent secretion activator 3 1,22 4 1,15 4 1,10 17,42 Dp Q80U28 Madd MAP-kinase activating death domain 2 1,21 2 1,10 3 0,98 12,18 Dp Q8BGD9 Eif4b eukaryotic translation initiation factor 4B 2 1,20 2 1,03 3 1,09 15,35 Dp Q8BGZ1 Hpcal4 hippocalcin-like 4 4 1,26 4 1,01 5 0,97 17,91 Dp Q8BH59 Slc25a12 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 4 1,20 4 1,13 5 1,06 23,68 Dp Q8BK64 Ahsa1 AHA1, activator of heat shock protein ATPase 1 4 1,21 4 1,01 5 1,13 25,03 Dp Q8BMF4 Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate 4 1,21 4 1,19 5 1,11 32,81 Dp dehydrogenase complex) Q8BNW9 Kbtbd11 kelch repeat and BTB (POZ) domain containing 11 2 1,29 2 1,12 3 0,88 9,71 Dp Q8CBE3 Wdr37 WD repeat domain 37 3 1,24 3 1,02 4 1,13 16,67 Dp Q8CGP6 Hist1h2ah histone cluster 1, H2ah 3 1,46 4 0,98 4 1,18 24,54 Dp Q8JZQ9 Eif3b eukaryotic translation initiation factor 3, subunit B 2 1,27 3 1,06 3 1,08 14,63 Dp Q8K1M6 Dnm1l dynamin 1-like 4 1,26 4 1,08 5 1,07 26,57 Dp Q8K212 Pacs1 phosphofurin acidic cluster sorting protein 1 3 1,25 3 1,12 4 1,07 18,77 Dp Q8R570 Snap47 synaptosomal-associated protein, 47 2 1,28 2 1,10 3 1,10 20,15 Dp Q8VDD5 Myh9 myosin, heavy polypeptide 9, non-muscle 2 1,23 2 1,08 3 1,05 22,89 Dp Q8VHH5 Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 3 1,35 4 1,03 5 1,05 31,88 Dp Q921F2 Tardbp TAR DNA binding protein 4 1,23 4 1,02 5 1,04 20,51 Dp Q9CQ92 Fis1 fission 1 (mitochondrial outer membrane) homolog (yeast) 2 1,23 3 1,01 3 1,11 9,54 Dp Q9CQM9 Glrx3 glutaredoxin 3 2 1,23 2 1,06 3 1,09 16,72 Dp Q9CQQ7 Atp5f1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 4 1,26 4 1,20 5 1,18 20,64 Dp Q9CR62 Slc25a11 solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), 4 1,21 4 1,20 5 1,18 18,15 Dp member 11 Q9CZM2 Rpl15 ribosomal protein L15 2 1,26 2 1,08 3 0,93 17,62 Dp Q9DB77 Uqcrc2 ubiquinol cytochrome c reductase core protein 2 2 1,26 2 1,15 3 1,03 14,11 Dp Q9JLM8 Dclk1 doublecortin-like kinase 1 2 1,21 2 1,17 3 1,07 13,08 Dp Q9QWI6 Srcin1 SRC kinase signaling inhibitor 1 3 1,46 3 1,14 4 1,18 18,02 Dp Q9QYS2 Grm3 glutamate receptor, metabotropic 3 2 1,38 2 0,98 2 1,12 16,36 Dp Q9QYX7 Pclo piccolo (presynaptic cytomatrix protein) 4 1,35 4 1,09 5 1,14 20,11 Dp Q9R0K7 Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 4 1,20 4 1,15 5 1,16 24,12 Dp Q9R0P9 Uchl1 ubiquitin carboxy-terminal hydrolase L1 2 1,22 2 1,15 3 1,18 18,01 Dp Q9R1Q8 Tagln3 transgelin 3 2 1,23 2 1,03 3 1,03 22,86 Dp Q9WU78 Pdcd6ip programmed cell death 6 interacting protein 3 1,22 3 1,10 4 1,10 20,70 Dp Q9WUA3 Pfkp phosphofructokinase, platelet 4 1,29 4 1,11 5 1,14 22,71 Dp Q9Z1B3 Plcb1 phospholipase C, beta 1 4 1,21 4 1,17 5 1,18 25,17 Dp Q9Z2X1 Hnrnpf heterogeneous nuclear ribonucleoprotein F 3 1,24 3 1,08 4 0,87 12,89 Dp P00493 Hprt hypoxanthine guanine phosphoribosyl transferase 4 1,78 4 1,18 5 1,46 19,67 Dp + (Dp-Tg) P05132 Prkaca protein kinase, cAMP dependent, catalytic, alpha 2 1,22 2 1,11 3 1,29 21,67 Dp + (Dp-Tg) P05202 Got2 glutamate oxaloacetate transaminase 2, mitochondrial 4 1,27 4 1,05 5 1,21 29,23 Dp + (Dp-Tg) P08228 Sod1 superoxide dismutase 1, soluble 2 1,23 2 1,07 3 1,24 18,80 Dp + (Dp-Tg) P14211 Calr calreticulin 2 1,40 2 1,18 3 1,21 20,66 Dp + (Dp-Tg) P18572 Bsg basigin 3 1,36 3 1,11 4 1,31 26,44 Dp + (Dp-Tg) P20152 Vim vimentin 2 1,35 3 1,04 3 1,29 22,21 Dp + (Dp-Tg) P23819 Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) 4 1,31 4 1,04 5 1,22 28,21 Dp + (Dp-Tg) P27546 Map4 microtubule-associated protein 4 2 1,31 3 1,17 3 1,26 15,91 Dp + (Dp-Tg) P28656 Nap1l1 nucleosome assembly protein 1-like 1 2 1,46 2 1,07 3 1,21 27,56 Dp + (Dp-Tg) P35564 Canx calnexin 2 1,36 2 1,17 2 1,33 25,31 Dp + (Dp-Tg) P55066 Ncan neurocan 4 1,36 4 1,13 5 1,24 31,57 Dp + (Dp-Tg) P55264 Adk adenosine kinase 3 1,29 3 1,12 4 1,24 18,00 Dp + (Dp-Tg) P56959 Fus fused in sarcoma 2 1,79 2 1,01 3 1,22 31,95 Dp + (Dp-Tg) P62717 Rpl18a ribosomal protein L18A 2 1,45 2 1,10 3 1,22 15,86 Dp + (Dp-Tg) P84084 Arf5 ADP-ribosylation factor 5 2 1,48 2 1,18 3 1,22 17,08 Dp + (Dp-Tg) Q3TMH2 Scrn3 secernin 3 3 1,27 4 1,01 4 1,22 10,23 Dp + (Dp-Tg) Q60625 Icam5 intercellular adhesion molecule 5, telencephalin 2 1,37 4 1,13 4 1,25 14,49 Dp + (Dp-Tg) Q68FF6 Git1 G protein-coupled receptor kinase-interactor 1 2 1,36 2 1,13 2 1,29 13,23 Dp + (Dp-Tg) Q6WVG3 Kctd12 potassium channel tetramerisation domain containing 12 3 1,27 3 1,09 4 1,29 22,24 Dp + (Dp-Tg) Q7M6Y3 Picalm phosphatidylinositol binding clathrin assembly protein 3 1,29 2 1,18 3 1,34 18,83 Dp + (Dp-Tg) Q91YQ5 Rpn1 ribophorin I 3 1,21 3 1,14 3 1,32 25,15 Dp + (Dp-Tg) Q99LC3 Ndufa10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10 4 1,21 4 1,10 5 1,21 18,78 Dp + (Dp-Tg) Q99NE5 Rims1 regulating synaptic membrane exocytosis 1 2 1,23 2 1,12 2 1,20 13,27 Dp + (Dp-Tg) Q9CZ13 Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 2 1,25 2 1,14 2 1,30 20,68 Dp + (Dp-Tg) Q9DCZ1 Gmpr guanosine monophosphate reductase 2 1,31 2 0,95 2 1,32 16,13 Dp + (Dp-Tg) Q9WUM3 Coro1b coronin, actin binding protein 1B 4 1,31 4 1,16 5 1,30 25,50 Dp + (Dp-Tg) Q9Z1S5 Sept3 septin 3 2 1,43 2 1,15 3 1,23 23,54 Dp + (Dp-Tg) O35927 Ctnnd2 catenin (cadherin associated protein), delta 2 2 1,50 2 1,23 3 1,14 23,66 Dp + Tg P09411 Unknown No associated gene 4 1,21 4 1,21 5 1,13 22,60 Dp + Tg P14148 Rpl7 ribosomal protein L7 2 1,43 2 1,21 3 1,14 18,52 Dp + Tg P20917 Mag myelin-associated glycoprotein 4 1,24 4 1,26 5 1,06 20,79 Dp + Tg P29758 Oat ornithine aminotransferase 2 1,27 2 1,23 3 1,12 20,61 Dp + Tg P35293 Rab18 RAB18, member RAS oncogene family 2 1,22 2 1,29 3 1,03 15,12 Dp + Tg P60487 Pdxp pyridoxal (pyridoxine, vitamin B6) phosphatase 2 1,25 2 1,20 3 1,06 23,70 Dp + Tg Q3TXX4 Slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate 4 1,24 4 1,27 5 1,09 28,86 Dp + Tg cotransporter), member 7 Q60875 Arhgef2 rho/rac guanine nucleotide exchange factor (GEF) 2 2 1,27 2 1,26 3 1,07 13,94 Dp + Tg Q61490 Alcam activated leukocyte cell adhesion molecule 4 1,26 4 1,21 5 1,07 20,57 Dp + Tg Q7TMB8 Cyfip1 cytoplasmic FMR1 interacting protein 1 3 1,23 3 1,29 4 1,13 15,82 Dp + Tg Q9CR16 Ppid peptidylprolyl isomerase D (cyclophilin D) 4 1,22 4 1,26 5 1,18 25,74 Dp + Tg Q9D394 Rufy3 RUN and FYVE domain containing 3 2 1,27 2 1,22 3 1,15 20,79 Dp + Tg Q9ESW4 Agk acylglycerol kinase 2 1,31 2 1,37 3 1,05 19,35 Dp + Tg Q9JME5 Ap3b2 adaptor-related protein complex 3, beta 2 subunit 4 1,32 4 1,20 5 1,18 15,88 Dp + Tg Q9R0P5 Dstn destrin 2 1,36 2 1,20 3 1,13 20,72 Dp + Tg O08539 Bin1 bridging integrator 1 4 1,26 4 1,31 5 1,31 22,27 Dp+Tg+(Dp-Tg) P60879 Snap25 synaptosomal-associated protein 25 4 1,25 4 1,25 4 1,21 22,69 Dp+Tg+(Dp-Tg) Q8BKC5 Ipo5 importin 5 3 1,26 3 1,30 5 1,21 21,13 Dp+Tg+(Dp-Tg) Q8R0A7 6430548M08Rik RIKEN cDNA 6430548M08 gene 2 1,36 2 1,32 3 1,23 23,92 Dp+Tg+(Dp-Tg) Q8VDQ1 Ptgr2 prostaglandin reductase 2 2 1,23 2 1,20 2 1,34 9,59 Dp+Tg+(Dp-Tg) Q91VD9 Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 4 1,26 4 1,31 5 1,25 19,04 Dp+Tg+(Dp-Tg) Q9CPU0 Glo1 glyoxalase 1 2 1,40 2 1,43 3 1,64 16,81 Dp+Tg+(Dp-Tg) Q9CYH2 Fam213a family with sequence similarity 213, member A 4 1,30 4 1,25 5 1,22 20,50 Dp+Tg+(Dp-Tg) Q9R0Q6 Arpc1a actin related protein 2/3 complex, subunit 1A 2 1,21 2 1,22 3 1,22 19,10 Dp+Tg+(Dp-Tg) Supplementary table 4: Topcluster analysis of the proteins expressed differentially in the the hippocampi derived from Dp1Yah (Dp), Tg(Dyrk1a) (Tg) and the [ Dp1Yah (Dp); Tg(Dyrk1a)] (Dp-Tg) animals

CATEGORY/ Title (or Source) Dp_logP Tg_logP (Dp,Tg)_logP Dp_ProteinSet Tg_ProteinSet (Dp,Tg)_ProteinSet ID GO: Molecular pValues Protein List Function GO:0031625 ubiquitin protein ligase binding 5.2266 CALR CLU DNAJA1 DNM1L HSPA5 PCBP2 PRKACA TCP1 UBE2O UCHL1 UQCRC1 GO:0044389 ubiquitin-like protein ligase binding 5.1667 CALR CLU DNAJA1 DNM1L HSPA5 PCBP2 PRKACA TCP1 UBE2O UCHL1 UQCRC1 GO:0005509 calcium ion binding 4.1439 ACTN1 ACTN4 ATP2B2 CADPS CALR CANX HPCAL4 HSPA5 NCAN NCL PCLO PLCB1 PPP3CB RYR2 SLC25A12 VSNL1 GO:0005310 dicarboxylic acid transmembrane transporter activity 4.1146 SLC17A7 SLC1A3 SLC25A11 SLC25A12 GO:0008092 cytoskeletal protein binding 10.0000 ARHGEF2 ARPC1A ATP1A1 BIN1 CAP2 CYFIP1 DSTN GRIA1 RAB3B RAB3C SIRT2 SNAP25 STX1A GO:0017022 myosin binding 5.8759 GRIA1 RAB3B RAB3C SNAP25 STX1A GO:0031489 myosin V binding 4.7034 GRIA1 RAB3B RAB3C GO:0016616 oxidoreductase activity, acting on the CH-OH group of 4.8036 AKR1A1 GPD1 IDH3A KCNAB2 PGD donors, NAD or NADP as acceptor PTGR2 GO:0016491 oxidoreductase activity 4.6284 AKR1A1 APEX1 GMPR GPD1 IDH3A KCNAB2 NDUFA10 NDUFS1 PGD PTGR2 SNCA SOD1 UQCRC1 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 4.3261 AKR1A1 GPD1 IDH3A KCNAB2 PGD PTGR2 GO:0051020 GTPase binding 4.4582 4.0131 ARHGEF2 BIN1 CYFIP1 EPRS BIN1 DOCK4 GIT1 IPO5 PRKACA GRIA1 IPO5 MAP2K1 RIMS1 RPH3A SOD1 GO:0032403 protein complex binding 5.9293 10.0000 ACTN1 ACTN4 ARHGEF2 ARPC1A ADD1 APEX1 ARPC1A ATP6V0D1 ATP1B1 BIN1 CALR CORO1A BIN1 CALR CORO1B GIT1 ICAM5 CORO1B CTSB CYFIP1 GFAP GIT1 KIF1A KIF5C MAP4 MYO18A NISCH GNAI1 GNB2 ICAM5 MAP4 MYH9 PRKACA RPH3A RTN4 SNCA PFKP PRKACA TPPP UQCRC1 UQCRC1 VIM WIPF3 UQCRC2 VIM GO:0042802 identical protein binding 5.6723 4.6585 ACTN1 ACTN4 ASS1 BIN1 CAMK2A ADD1 ALB BIN1 CORO1B FUS GIT1 CORO1A CORO1B DNM1L FUS GOT2 GPD1 GRIA2 HPRT1 MFF GIT1 GOT2 GRIA2 GSTM1 HPRT1 NISCH PDE2A PICALM PRKAR2A MYH9 NCL NEFL OAT PDCD6IP SNCA SOD1 VIM PFKM PICALM PLCB1 RPL7 RYR2 SOD1 TARDBP VIM GO:0051015 actin filament binding 5.1613 4.5520 ACTN1 ACTN4 ARPC1A BIN1 ADD1 ARPC1A BIN1 CORO1B CORO1A CORO1B CYFIP1 MYH9 MYO18A WIPF3 GO:0051087 chaperone binding 4.4923 4.5102 AHSA1 CALR CLU DNAJA1 HSPA5 ALB ATP1A1 CALR HYOU1 SOD1 SOD1 GO: Biological pValues Protein List Process GO:0034975 protein folding in endoplasmic reticulum 10.0000 CALR CANX HSPA5 PDIA3 GO:0000902 cell morphogenesis 10.0000 ACTN1 ACTN4 ALCAM ARHGEF2 ATP2B2 ATP6V1D CALR CAMK2A CLU CORO1A CORO1B CTNND2 CYFIP1 DCLK1 HNRNPK HPRT1 MAG MAP4 MBP MYH9 NEFL PACSIN1 PICALM PPP3CB RIMS1 RUFY3 SLC1A3 SNAP91 SOD1 SRCIN1 UCHL1 VIM GO:0032990 cell part morphogenesis 10.0000 ALCAM ATP6V1D CAMK2A CLU CORO1B CTNND2 CYFIP1 DCLK1 DNM1L FIS1 HNRNPK HPRT1 MAG MAP4 MBP NEFL PACSIN1 PICALM PPP3CB RIMS1 RUFY3 SNAP91 SRCIN1 UCHL1 VIM GO:0048858 cell projection morphogenesis 10.0000 ALCAM ATP6V1D CAMK2A CLU CORO1B CTNND2 CYFIP1 DCLK1 HNRNPK HPRT1 MAG MAP4 MBP NEFL PACSIN1 PICALM PPP3CB RIMS1 RUFY3 SNAP91 SRCIN1 UCHL1 VIM GO:0046903 secretion 10.0000 ACTN1 ACTN4 ATP2B2 CADPS CAMK2A CANX CLU CORO1A DNM1L MADD NCL PCLO PDCD6IP PFKM PLCB1 PPID PPP3CB RIMS1 SCRN3 SLC17A7 SLC1A3 SNAP25 SNAP47 SNAP91 SOD1 SRCIN1 TARDBP TUBA4A VSNL1 GO:0099536 synaptic signaling 10.0000 ATP2B2 BCAN BSN CADPS CAMK2A CTNND2 GFAP GNAI1 GRIA2 GRM3 GRM5 HNRNPK MBP PCLO PLCB1 PPP3CB PRKACA PRKCG RIMS1 SLC17A7 SLC1A3 SNAP25 SNAP47 SNAP91 GO:0051050 positive regulation of transport 10.0000 ACTN4 ATP1B1 ATP2B2 BIN1 CADPS CALR CAMK2A DNM1L FIS1 HNRNPK IPO5 NCL PDCD6IP PFKM PLCB1 PPID PPP3CB PRKACA RIMS1 RUFY3 RYR2 SNAP25 TARDBP VSNL1 GO:0050803 regulation of synapse structure or activity 10.0000 ATP2B2 BCAN CAMK2A CTNND2 GFAP GRM5 HNRNPK NCAN PPP3CB RIMS1 SNAP25 SNAP47 GO:0032940 secretion by cell 10.0000 ACTN1 ACTN4 CADPS CAMK2A CANX CLU CORO1A DNM1L MADD NCL PCLO PDCD6IP PFKM PLCB1 PPID PPP3CB RIMS1 SCRN3 SLC17A7 SLC1A3 SNAP25 SNAP47 SNAP91 SOD1 SRCIN1 TARDBP TUBA4A VSNL1 GO:0030030 cell projection organization 10.0000 ALCAM ATP2B2 ATP6V1D CAMK2A CLU CORO1A CORO1B CTNND2 CYFIP1 DCLK1 GFAP GIT1 HNRNPK HPRT1 MAG MAP4 MBP MYH9 NEFL PACSIN1 PICALM PPP3CB RIMS1 RUFY3 SNAP25 SNAP91 SOD1 SRCIN1 UCHL1 VIM GO:0048666 neuron development 10.0000 ALCAM ATP2B2 CAMK2A CLU CTNND2 CYFIP1 DCLK1 GFAP GIT1 HNRNPK HPRT1 MAG MAP4 MBP NEFL PACSIN1 PICALM PPP3CB RIMS1 RUFY3 SLC1A3 SNAP25 SNAP91 SOD1 SRCIN1 UCHL1 VIM GO:0099537 trans-synaptic signaling 10.0000 ATP2B2 BCAN BSN CADPS CAMK2A CTNND2 GFAP GNAI1 GRIA2 GRM3 GRM5 HNRNPK MBP PCLO PPP3CB PRKACA PRKCG RIMS1 SLC17A7 SLC1A3 SNAP25 SNAP47 SNAP91 GO:0007268 chemical synaptic transmission 10.0000 ATP2B2 BCAN BSN CADPS CAMK2A CTNND2 GFAP GNAI1 GRIA2 GRM3 GRM5 HNRNPK MBP PCLO PPP3CB PRKACA PRKCG RIMS1 SLC17A7 SLC1A3 SNAP25 SNAP47 SNAP91

GO:0051656 establishment of organelle localization 10.0000 ACTN4 AP3B2 ARHGEF2 CADPS CANX MAP4 MYH9 NEFL PACSIN1 PCLO PDCD6IP RIMS1 SNAP25 SNAP47 UCHL1 GO:0031175 neuron projection development 10.0000 ALCAM CAMK2A CLU CTNND2 CYFIP1 DCLK1 GFAP GIT1 HNRNPK HPRT1 MAG MAP4 MBP NEFL PACSIN1 PICALM PPP3CB RIMS1 RUFY3 SNAP25 SNAP91 SRCIN1 UCHL1 VIM GO:0030182 neuron differentiation 10.0000 ALCAM ATP2B2 BIN1 CALR CAMK2A CLU CTNND2 CYFIP1 DCLK1 GFAP GIT1 HNRNPK HPRT1 MAG MAP4 MBP NEFL PACSIN1 PICALM PPP3CB RIMS1 RUFY3 SLC1A3 SNAP25 SNAP91 SOD1 SRCIN1 UCHL1 VIM GO:0000904 cell morphogenesis involved in differentiation 10.0000 ACTN1 ACTN4 ALCAM ATP2B2 CALR CAMK2A CTNND2 CYFIP1 DCLK1 HPRT1 MAG MBP MYH9 NEFL PICALM PPP3CB RUFY3 SLC1A3 SNAP91 SOD1 SRCIN1 UCHL1 VIM GO:0050804 modulation of synaptic transmission 10.0000 ATP2B2 BCAN CAMK2A CTNND2 GFAP GNAI1 GRIA2 GRM3 GRM5 HNRNPK PPP3CB PRKACA RIMS1 SLC1A3 SNAP25 SNAP47 GO:0048667 cell morphogenesis involved in neuron differentiation 10.0000 ALCAM ATP2B2 CAMK2A CTNND2 CYFIP1 DCLK1 HPRT1 MAG MBP NEFL PICALM PPP3CB RUFY3 SLC1A3 SNAP91 SOD1 SRCIN1 UCHL1 VIM GO:0048812 neuron projection morphogenesis 10.0000 ALCAM CAMK2A CLU CTNND2 CYFIP1 DCLK1 HNRNPK HPRT1 MAG MBP NEFL PACSIN1 PICALM PPP3CB RIMS1 RUFY3 SNAP91 SRCIN1 UCHL1 VIM GO:0048167 regulation of synaptic plasticity 10.0000 ATP2B2 BCAN CAMK2A CTNND2 GFAP GRM5 HNRNPK PPP3CB RIMS1 SNAP25 SNAP47 GO:0007267 cell-cell signaling 10.0000 ATP2B2 BCAN BSN CADPS CAMK2A CTNND2 GFAP GNAI1 GRIA2 GRM3 GRM5 HNRNPK MADD MBP PCLO PFKM PLCB1 PPP3CB PRKACA PRKCG RIMS1 RYR2 SLC17A7 SLC1A3 SNAP25 SNAP47 SNAP91 TARDBP VSNL1 GO:0032989 cellular component morphogenesis 10.0000 ACTN1 ACTN4 ALCAM ARHGEF2 ATP2B2 ATP6V1D CALR CAMK2A CLU CORO1A CORO1B CTNND2 CYFIP1 DCLK1 DNM1L FIS1 HNRNPK HPRT1 MAG MAP4 MBP MYH9 NEFL PACSIN1 PICALM PPP3CB RIMS1 RUFY3 SLC1A3 SNAP91 SOD1 SRCIN1 UCHL1 VIM GO:0098916 anterograde trans-synaptic signaling 10.0000 ATP2B2 BCAN BSN CADPS CAMK2A CTNND2 GFAP GNAI1 GRIA2 GRM3 GRM5 HNRNPK MBP PCLO PPP3CB PRKACA PRKCG RIMS1 SLC17A7 SLC1A3 SNAP25 SNAP47 SNAP91

GO:1902580 single-organism cellular localization 5.8122 ACTN4 AGAP3 AP3B2 ARHGEF2 ATP1B1 BSG CADPS CANX FIS1 G3BP2 IPO5 MAP4 MYH9 NEFL PACS1 PACSIN1 PCLO PDCD6IP PDIA3 PPP3CB RIMS1 RPL15 RPL18A RPL7 SNAP25 SNAP47 UCHL1 GO:1901698 response to nitrogen compound 5.5546 ARHGEF2 ASS1 ATP6V1D BSG CAMK2A CTSB GNAI1 GNB2 GSTM1 HNRNPK HPRT1 IPO5 NEFL PDXP PLCB1 PRKACA PRKCG RYR2 SLC1A3 SLC3A2 SOD1 UQCRC1 GO:0006836 neurotransmitter transport 5.4183 CADPS CAMK2A GFAP PCLO RIMS1 SLC17A7 SLC1A3 SNAP25 SNAP47 SNAP91 GO:0001505 regulation of neurotransmitter levels 5.3640 CADPS CAMK2A GFAP PCLO RIMS1 SLC17A7 SLC1A3 SNAP25 SNAP47 SNAP91 GO:0060627 regulation of vesicle-mediated transport 5.2951 ACTN4 BIN1 CADPS CALR CORO1A HNRNPK PACSIN1 PCLO PDCD6IP PICALM PLCB1 PRKCG RIMS1 SNAP91 VSNL1 GO:0010243 response to organonitrogen compound 5.2665 ARHGEF2 ASS1 ATP6V1D BSG CAMK2A CTSB GNAI1 GNB2 HNRNPK HPRT1 IPO5 NEFL PDXP PLCB1 PRKACA PRKCG RYR2 SLC1A3 SOD1 UQCRC1 GO:0051640 organelle localization 5.2541 ACTN4 AP3B2 ARHGEF2 CADPS CANX MAP4 MYH9 NEFL PACSIN1 PCLO PDCD6IP RIMS1 SNAP25 SNAP47 UCHL1 GO:0016082 synaptic vesicle priming 5.2103 CADPS RIMS1 SNAP25 SNAP47 GO:0009167 purine ribonucleoside monophosphate metabolic process 5.1600 ADK ATP1B1 ATP5F1 DNM1L HPRT1 NDUFA10 NDUFS1 PFKM PFKP UQCRC1 UQCRC2 GO:0009126 purine nucleoside monophosphate metabolic process 5.1453 ADK ATP1B1 ATP5F1 DNM1L HPRT1 NDUFA10 NDUFS1 PFKM PFKP UQCRC1 UQCRC2 GO:0006457 protein folding 5.0075 CALR CANX CLU DNAJA1 GNAI1 GNB2 HSPA5 PDIA3 PPID TCP1 GO:0007015 actin filament organization 5.0047 ACTN1 ACTN4 ARHGEF2 ARPC1A CORO1A CORO1B CYFIP1 DSTN MYH9 PACSIN1 PDXP RUFY3 GO:0009161 ribonucleoside monophosphate metabolic process 4.9876 ADK ATP1B1 ATP5F1 DNM1L HPRT1 NDUFA10 NDUFS1 PFKM PFKP UQCRC1 UQCRC2 GO:0030029 actin filament-based process 4.9152 ACTN1 ACTN4 ARHGEF2 ARPC1A CALR CORO1A CORO1B CRK CYFIP1 DSTN MYH9 PACSIN1 PDXP RUFY3 RYR2 TPM3 VIM GO:0060341 regulation of cellular localization 4.9133 CADPS CAMK2A CORO1A DCLK1 DNM1L FIS1 G3BP2 HNRNPK IPO5 MADD NCL PCLO PDCD6IP PFKM PLCB1 PPID PPP3CB PRKACA RIMS1 RUFY3 RYR2 SNAP25 SRCIN1 TARDBP TCP1 VSNL1 GO:0061024 membrane organization 4.8113 ATP1B1 BSG CAMK2A CLU CORO1A DNM1L FIS1 MBP MYH9 PACS1 PACSIN1 PDCD6IP PICALM RIMS1 RPL15 RPL18A RPL7 SNAP25 SNAP47 SNAP91 SOD1 GO:0009123 nucleoside monophosphate metabolic process 4.8103 ADK ATP1B1 ATP5F1 DNM1L HPRT1 NDUFA10 NDUFS1 PFKM PFKP UQCRC1 UQCRC2 GO:0046185 aldehyde catabolic process 5.0259 ADH5 GLO1 PDXP GO:0090066 regulation of anatomical structure size 4.7004 ARPC1A CYFIP1 DSTN MAP2K1 MGLL PDXP RAB3B RUFY3 SOD2 GO:0010035 response to inorganic substance 10.0000 ACO1 ALB APEX1 BSG C1QA CALR EEF1A2 FUS GART LONP1 PSAP SNCA SOD1 TF GO:0045333 cellular respiration 5.9041 ACO1 GPD1 IDH3A NDUFA10 NDUFS1 PRKACA SNCA UQCRC1 GO:0019752 carboxylic acid metabolic process 5.8142 AARS ACO1 AKR1A1 ASRGL1 BSG CNDP2 DDAH1 GART GLO1 GOT2 GPD1 IDH3A NCAN PGD PPA2 PTGR2 SNCA GO:0098657 import into cell 5.4004 ATP1A1 PICALM SNAP25 SNCA TF GO:0010038 response to metal ion 5.2983 ACO1 ALB BSG C1QA CALR FUS LONP1 SNCA SOD1 TF GO:0043436 oxoacid metabolic process 5.2024 AARS ACO1 AKR1A1 ASRGL1 BSG CNDP2 DDAH1 GART GLO1 GOT2 GPD1 IDH3A NCAN PGD PPA2 PTGR2 SNCA GO:1990267 response to transition metal nanoparticle 5.1983 ACO1 ALB BSG C1QA SNCA SOD1 TF GO:0055114 oxidation-reduction process 5.1928 ACO1 AKR1A1 APEX1 FAM213A GMPR GPD1 IDH3A KCNAB2 NDUFA10 NDUFS1 PGD PRKACA PTGR2 SNCA SOD1 UQCRC1 GO:0006082 organic acid metabolic process 5.1157 AARS ACO1 AKR1A1 ASRGL1 BSG CNDP2 DDAH1 GART GLO1 GOT2 GPD1 IDH3A NCAN PGD PPA2 PTGR2 SNCA GO:0009117 nucleotide metabolic process 4.9821 ADK GART GMPR GPD1 HPRT1 IDH3A KCNAB2 NDUFA10 NDUFS1 PDE2A PGD SNCA UQCRC1 GO:0006753 nucleoside phosphate metabolic process 4.9160 ADK GART GMPR GPD1 HPRT1 IDH3A KCNAB2 NDUFA10 NDUFS1 PDE2A PGD SNCA UQCRC1 GO:0034622 cellular macromolecular complex assembly 10.0000 10.0000 ARPC1A BIN1 CADPS CALR CLU ADD1 ARPC1A BIN1 CALR CORO1B CORO1A CORO1B CYFIP1 DNM1L IPO5 LONP1 NAP1L1 NDUFA10 EIF3B EIF4B IPO5 MYH9 NAP1L1 NDUFS1 PICALM RIMS1 RTN4 NDUFA10 NDUFS1 NEFL PICALM SAMM50 SNAP25 SNCA STX1B RIMS1 SNAP25 SNAP47 SNAP91 WIPF3 TCP1 TPPP GO:0043623 cellular protein complex assembly 10.0000 10.0000 ARPC1A CADPS CALR CLU ADD1 ARPC1A CALR CORO1B IPO5 CORO1A CORO1B CYFIP1 DNM1L LONP1 NDUFA10 NDUFS1 PICALM EIF4B IPO5 MYH9 NDUFA10 RIMS1 RTN4 SAMM50 SNAP25 NDUFS1 NEFL PICALM RIMS1 SNCA STX1B WIPF3 SNAP25 SNAP47 SNAP91 TCP1 TPPP GO:0006887 exocytosis 10.0000 5.4482 ACTN1 ACTN4 CADPS CLU ALB CPLX1 PSAP RIMS1 RPH3A CORO1A PCLO PDCD6IP PLCB1 SCRN3 SNAP25 SNCA SOD1 STX1B PPP3CB RIMS1 SCRN3 SNAP25 TF SNAP47 SOD1 SRCIN1 TUBA4A VSNL1 GO:0006897 endocytosis 10.0000 5.1666 ACTN4 ARPC1A BIN1 CALR CANX ADD1 ALB ARPC1A BIN1 CALR CORO1A CRK CYFIP1 CYFIP2 CANX GRIA2 HYOU1 ICAM5 PICALM DNM1L GRIA2 HNRNPK ICAM5 SNCA TF WIPF3 MYH9 NCL PACSIN1 PICALM PRKCG SNAP91 GO:0045055 regulated exocytosis 10.0000 4.9739 ACTN1 ACTN4 CADPS CLU ALB CPLX1 PSAP RIMS1 RPH3A CORO1A PCLO PLCB1 PPP3CB SNAP25 SOD1 STX1B TF RIMS1 SNAP25 SNAP47 SOD1 TUBA4A GO:0099504 synaptic vesicle cycle 5.4820 5.9466 CADPS CANX PACSIN1 PCLO CANX CPLX1 RIMS1 RPH3A RIMS1 SLC17A7 SNAP25 SNAP47 SNAP25 SNCA STX1B GO:0048489 synaptic vesicle transport 5.1788 5.6729 AP3B2 CADPS CANX PACSIN1 CANX CPLX1 RIMS1 RPH3A PCLO RIMS1 SNAP25 SNAP47 SNAP25 SNCA STX1B GO:0097480 establishment of synaptic vesicle localization 5.1788 5.6729 AP3B2 CADPS CANX PACSIN1 CANX CPLX1 RIMS1 RPH3A PCLO RIMS1 SNAP25 SNAP47 SNAP25 SNCA STX1B GO:0097479 synaptic vesicle localization 4.9934 5.5050 AP3B2 CADPS CANX PACSIN1 CANX CPLX1 RIMS1 RPH3A PCLO RIMS1 SNAP25 SNAP47 SNAP25 SNCA STX1B GO: Cellular pValues Protein List Component GO:0032838 cell projection cytoplasm 10.0000 AP3B2 CAMK2A CANX GRIA2 MAP2K4 NEFL SOD1 UCHL1 GO:0030425 dendrite 10.0000 ACTN1 ALCAM ARHGEF2 ATP2B2 BCAN BSN CAMK2A CANX CLU CTNND2 EIF4B FUS GLRX3 GRIA2 GRM3 GRM5 HNRNPK MAP2K4 PCLO PRKCG RUFY3 SLC1A3 SNAP47 SOD1 SRCIN1 SYNCRIP GO:0030863 cortical cytoskeleton 10.0000 ACTN1 ACTN4 BSN CORO1A DSTN MYH9 PCLO TPM3 GO:0099568 cytoplasmic region 10.0000 ACTN1 ACTN4 AP3B2 BSN CAMK2A CANX CORO1A DSTN GLRX3 GRIA2 HNRNPK MAP2K4 MYH9 NCL NEFL PCLO SOD1 TPM3 UCHL1 GO:0097060 synaptic membrane 5.7399 CAMK2A GRIA2 GRM3 KCTD12 NIPSNAP1 PICALM PRKCG RIMS1 SEPT3 SNAP25 SNAP91 SRCIN1 GO:0005938 cell cortex 5.4250 ACTN1 ACTN4 BSN CORO1A DSTN GLRX3 HNRNPK MYH9 NCL PCLO TPM3 GO:0031252 cell leading edge 5.3156 ACTN1 ARHGAP1 ARHGEF2 CORO1A CORO1B CYFIP1 MYH9 PACSIN1 PDXP RUFY3 SNAP25 SRCIN1 VIM GO:0048786 presynaptic active zone 5.1866 BSN GRM3 PCLO RIMS1 SLC17A7 GO:0044448 cell cortex part 5.1484 ACTN1 ACTN4 BSN CORO1A DSTN MYH9 PCLO TPM3 GO:0005790 smooth endoplasmic reticulum 5.0708 CALR CANX HSPA5 PDIA3 RYR2 GO:0015629 actin cytoskeleton 5.0312 ACTN1 ACTN4 ARPC1A BIN1 CORO1A CORO1B CRK DSTN HNRNPK MYH9 PDXP SNAP25 SRCIN1 TPM3 GO:0044433 cytoplasmic vesicle part 4.9994 ACTN1 ACTN4 AP3B2 BSG CADPS CALR CAMK2A CAMKV CLU CORO1A DNM1L GRIA2 PACSIN1 PICALM SLC17A7 SNAP91 GO:0030017 sarcomere 4.8503 ACTN1 ACTN4 BIN1 GLRX3 PPP3CB RPL15 RPL7 RYR2 TPM3 GO:0043197 dendritic spine 4.8409 ACTN1 CANX FUS GRIA2 GRM3 GRM5 HNRNPK SLC1A3 GO:0044309 neuron spine 4.7996 ACTN1 CANX FUS GRIA2 GRM3 GRM5 HNRNPK SLC1A3 GO:0005740 mitochondrial envelope 4.6450 AGK ASS1 ATP5F1 CLU DNM1L FIS1 GOT2 NDUFA10 NDUFS1 NIPSNAP1 PDIA3 SLC1A3 SLC25A11 SLC25A12 SOD1 GO:0044449 contractile fiber part 4.5682 ACTN1 ACTN4 BIN1 GLRX3 PPP3CB RPL15 RPL7 RYR2 TPM3 GO:0030016 myofibril 4.4902 ACTN1 ACTN4 BIN1 GLRX3 PPP3CB RPL15 RPL7 RYR2 TPM3 GO:0098831 presynaptic active zone cytoplasmic component 4.2856 BSN PCLO GO:0048788 cytoskeleton of presynaptic active zone 4.2856 BSN PCLO GO:0099569 presynaptic cytoskeleton 4.2856 BSN PCLO GO:0043292 contractile fiber 4.2826 ACTN1 ACTN4 BIN1 GLRX3 PPP3CB RPL15 RPL7 RYR2 TPM3 GO:0044445 cytosolic part 4.2826 NEFL PFKM PFKP RPL15 RPL18A RPL7 SNAP25 SNAP47 TCP1 GO:0043204 perikaryon 4.0800 ASS1 CTNND2 FUS GOT2 GRIA2 MAP2K4 RUFY3 GO:0044429 mitochondrial part 4.0630 AGK ASS1 ATP5F1 CLU DLAT DNM1L FIS1 GOT2 NDUFA10 NDUFS1 NIPSNAP1 OAT PDIA3 SLC1A3 SLC25A11 SLC25A12 SOD1 UQCRC1 UQCRC2 GO:0030659 cytoplasmic vesicle membrane 4.0522 ACTN1 AP3B2 BSG CADPS CAMK2A CAMKV CORO1A DNM1L GRIA2 PACSIN1 PICALM SLC17A7 SNAP91 GO:0097449 astrocyte projection 4.0044 GFAP GRM3 GRM5 GO:0005912 adherens junction 10.0000 5.1948 ACTN1 ACTN4 ALCAM ARHGEF2 ALCAM ARHGEF2 CTNND2 CYFIP1 BSG CALR CORO1B CTNND2 HYOU1 MAP2K1 PRKAR2A RPL7 CYFIP1 GIT1 GNB2 HNRNPK HSPA5 RPS2 MYH9 PCBP2 PDCD6IP PDIA3 RPL7 SRCIN1 VIM GO:0070161 anchoring junction 10.0000 5.0603 ACTN1 ACTN4 ALCAM ARHGEF2 ALCAM ARHGEF2 CTNND2 CYFIP1 BSG CALR CORO1B CTNND2 HYOU1 MAP2K1 PRKAR2A RPL7 CYFIP1 GIT1 GNB2 HNRNPK HSPA5 RPS2 MYH9 PCBP2 PDCD6IP PDIA3 RPL7 SRCIN1 VIM GO:0005925 focal adhesion 10.0000 4.9398 ACTN1 ACTN4 ALCAM ARHGEF2 ALCAM ARHGEF2 CYFIP1 HYOU1 BSG CALR CORO1B CYFIP1 GIT1 MAP2K1 PRKAR2A RPL7 RPS2 GNB2 HNRNPK HSPA5 MYH9 PCBP2 PDCD6IP PDIA3 RPL7 SRCIN1 VIM GO:0005924 cell-substrate adherens junction 10.0000 4.9000 ACTN1 ACTN4 ALCAM ARHGEF2 ALCAM ARHGEF2 CYFIP1 HYOU1 BSG CALR CORO1B CYFIP1 GIT1 MAP2K1 PRKAR2A RPL7 RPS2 GNB2 HNRNPK HSPA5 MYH9 PCBP2 PDCD6IP PDIA3 RPL7 SRCIN1 VIM GO:0030055 cell-substrate junction 10.0000 4.8608 ACTN1 ACTN4 ALCAM ARHGEF2 ALCAM ARHGEF2 CYFIP1 HYOU1 BSG CALR CORO1B CYFIP1 GIT1 MAP2K1 PRKAR2A RPL7 RPS2 GNB2 HNRNPK HSPA5 MYH9 PCBP2 PDCD6IP PDIA3 RPL7 SRCIN1 VIM GO:0044304 main axon 4.2849 BIN1 MAG MGLL SIRT2 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex 4.1273 SNAP25 STX1A GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex 4.3484 SNAP25 STX1A GO:0044300 cerebellar mossy fiber 3.8067 BIN1 SLC17A7 GO:0043679 axon terminus 4.8276 ATP6V0D1 BIN1 CPLX1 GRIA2 KCNAB2 SNAP25 SNCA GO:0030133 transport vesicle 10.0000 4.5079 ATP6V0D1 BIN1 GRIA1 MFF RAB3B ATP6V0D1 BIN1 GRIA2 MFF PICALM RAB3C SLC17A7 SNAP25 STX1A RPH3A SNAP25 SNCA STX1B GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex 4.3484 3.9673 SNAP25 STX1A CPLX1 SNAP25 GO:0098794 postsynapse 10.0000 10.0000 ACTN1 ARHGEF2 BSN CAMK2A ADD1 ATP1A1 CANX FUS GRIA2 CANX CTNND2 DCLK1 FUS GRIA2 KCNAB2 KCTD12 MAP4 PICALM GRM3 GRM5 HNRNPK KCTD12 RIMS1 RTN4 SNCA MAP4 PCLO PICALM PRKCG RIMS1 SLC17A7 SLC1A3 SNAP91 SRCIN1 GO:0042734 presynaptic membrane 10.0000 10.0000 CAMK2A GRIA2 GRM3 KCTD12 GRIA2 KCTD12 PDE2A PICALM PICALM RIMS1 SEPT3 SNAP25 RIMS1 SEPT3 SNAP25 SNAP91 GO:0048471 perinuclear region of cytoplasm 10.0000 5.6389 ACTN4 ARF5 ARHGAP1 CALR CLU ADD1 APEX1 ARF5 CALR CORO1B CORO1B CTSB CYFIP1 CYFIP2 FUS PDE2A PICALM PRKACA DNAJA1 DNM1L FUS GNB2 PACS1 PRKAR2A SNAP25 SNCA TF VIM PACSIN1 PCLO PICALM PRKACA PRKCG SNAP25 SNAP47 TPPP VIM GO:0048770 pigment granule 10.0000 5.2336 BSG CANX CTSB HSPA5 NAP1L1 ATP1A1 ATP1B3 BSG CANX NAP1L1 PDCD6IP PDIA3 RPN1 SLC3A2 RPN1 GO:0042470 melanosome 10.0000 5.2336 BSG CANX CTSB HSPA5 NAP1L1 ATP1A1 ATP1B3 BSG CANX NAP1L1 PDCD6IP PDIA3 RPN1 SLC3A2 RPN1 GO:0098796 membrane protein complex 5.1637 10.0000 ALCAM AP3B2 ATP1B1 ATP5F1 ATP1A1 ATP1B3 ATP6V0D1 CALR ATP6V1D CALR GNAI1 GNB2 GRIA2 CPLX1 GRIA2 KCNAB2 NDUFA10 MYH9 NDUFA10 NDUFS1 PDIA3 NDUFS1 PICALM PRKACA RPN1 PICALM PRKACA RPN1 RYR2 SAMM50 SNAP25 SNCA STX1B TF SNAP25 SNAP47 SNAP91 UQCRC1 UQCRC1 UQCRC2 GO:0099572 postsynaptic specialization 10.0000 5.0913 ARHGEF2 BSN CAMK2A CTNND2 ADD1 ATP1A1 GRIA2 KCNAB2 DCLK1 GRIA2 GRM3 GRM5 MAP4 PICALM RIMS1 RTN4 HNRNPK MAP4 PCLO PICALM PRKCG RIMS1 SNAP91 SRCIN1 GO:0014069 postsynaptic density 10.0000 5.0913 ARHGEF2 BSN CAMK2A CTNND2 ADD1 ATP1A1 GRIA2 KCNAB2 DCLK1 GRIA2 GRM3 GRM5 MAP4 PICALM RIMS1 RTN4 HNRNPK MAP4 PCLO PICALM PRKCG RIMS1 SNAP91 SRCIN1 GO:0098590 plasma membrane region 10.0000 4.4867 ARHGEF2 ARPC1A ATP1B1 ATP2B2 AKR1A1 ARPC1A ATP1A1 ATP1B3 CAMK2A CTSB GRIA2 GRM3 ATP6V0D1 GRIA2 KCTD12 PDE2A KCTD12 NIPSNAP1 PACSIN1 PDIA3 PICALM PRKACA PRKAR2A RIMS1 PDXP PFKM PICALM PRKACA SEPT3 SNAP25 TF PRKCG RIMS1 SEPT3 SLC1A3 SLC3A2 SLC4A4 SNAP25 SNAP91 SRCIN1 GO:0044297 cell body 10.0000 4.4208 ALCAM ARHGEF2 ASS1 ATP2B2 CANX CPLX1 EEF1A2 FUS GOT2 BSN CAMK2A CANX CTNND2 EIF4B GRIA2 KIF1A PICALM RTN4 SNAP25 FUS GFAP GNB2 GOT2 GRIA2 SOD1 VIM MAP2K4 MBP PCLO PICALM RUFY3 SLC1A3 SNAP25 SNAP47 SOD1 SRCIN1 SYNCRIP TCP1 UCHL1 VIM GO:0043025 neuronal cell body 10.0000 4.1901 ALCAM ARHGEF2 ASS1 ATP2B2 CANX CPLX1 EEF1A2 FUS GOT2 BSN CAMK2A CANX CTNND2 EIF4B GRIA2 KIF1A PICALM RTN4 SNAP25 FUS GOT2 GRIA2 MAP2K4 MBP SOD1 PCLO PICALM RUFY3 SLC1A3 SNAP25 SNAP47 SOD1 SRCIN1 SYNCRIP UCHL1 GO:0036477 somatodendritic compartment 10.0000 4.1061 ACTN1 ALCAM ARHGEF2 ASS1 ADD1 CANX CPLX1 EEF1A2 FUS ATP2B2 BCAN BSN CAMK2A CANX GOT2 GRIA2 KIF1A PDE2A PICALM CLU CTNND2 EIF4B FUS GLRX3 RTN4 SNAP25 SOD1 GOT2 GRIA2 GRM3 GRM5 HNRNPK MAP2K4 MBP PCLO PICALM PRKCG RUFY3 SLC1A3 SNAP25 SNAP47 SOD1 SRCIN1 SYNCRIP GO:0098589 membrane region 10.0000 4.0853 ARHGEF2 ARPC1A ATP1B1 ATP2B2 AKR1A1 ARPC1A ATP1A1 ATP1B3 BSG CAMK2A CTSB DNM1L GNAI1 ATP6V0D1 BSG GRIA2 KCTD12 GRIA2 GRM3 KCTD12 NIPSNAP1 PDE2A PICALM PRKACA PRKAR2A PACSIN1 PDIA3 PDXP PFKM RIMS1 SEPT3 SNAP25 TF PICALM PRKACA PRKCG RIMS1 SEPT3 SLC1A3 SLC3A2 SLC4A4 SNAP25 SNAP91 SRCIN1 GO:1990204 oxidoreductase complex 4.1176 5.4077 DLAT GMPR NDUFA10 NDUFS1 GMPR GPD1 NDUFA10 NDUFS1 UQCRC1 UQCRC2 SNCA UQCRC1 GO:0044306 neuron projection terminus 4.8503 4.6383 BIN1 BSN GRIA2 HNRNPK PACSIN1 ATP6V0D1 BIN1 CPLX1 GRIA2 PCLO SNAP25 SNAP91 UCHL1 KCNAB2 SNAP25 SNCA GO:0032839 dendrite cytoplasm 10.0000 4.0229 CAMK2A CANX GRIA2 MAP2K4 CANX GRIA2 SOD1 SOD1 GO:0044456 synapse part 10.0000 10.0000 10.0000 ACTN1 ARHGEF2 BIN1 BSN CADPS ARHGEF2 ATP1A1 ATP6V0D1 BIN1 ADD1 ATP1A1 ATP6V0D1 BIN1 CAMK2A CANX CTNND2 DCLK1 CAP2 CTNND2 GRIA1 MFF RAB3B CANX CPLX1 FUS GRIA2 KCNAB2 DNM1L FUS GRIA2 GRM3 GRM5 RAB3C SLC17A7 SNAP25 STX1A KCTD12 MAP4 MFF PDE2A PICALM HNRNPK KCTD12 MADD MAP4 RIMS1 RPH3A RTN4 SEPT3 SNAP25 NIPSNAP1 PACSIN1 PCLO PICALM SNCA STX1B PRKCG RIMS1 SEPT3 SLC17A7 SLC1A3 SNAP25 SNAP47 SNAP91 SRCIN1 GO:0043005 neuron projection 10.0000 10.0000 10.0000 ACTN1 ACTN4 ALCAM AP3B2 ALCAM AP3B2 ARHGEF2 ATP6V0D1 ADD1 ATP6V0D1 BIN1 CANX CPLX1 ARHGEF2 ASS1 ATP2B2 BCAN BIN1 BIN1 CTNND2 CYFIP1 GRIA1 MAG FUS GIT1 GPRIN1 GRIA2 KCNAB2 BSN CAMK2A CANX CLU CORO1A MAP2K1 MGLL RUFY3 S100A1 KIF1A KIF5C MAP4 NAP1L1 PDE2A CTNND2 CYFIP1 CYFIP2 EIF4B FUS SIRT2 SLC17A7 SNAP25 STX1A PRKACA RPH3A RTN4 SEPT3 GIT1 GLRX3 GRIA2 GRM3 GRM5 SNAP25 SNCA SOD1 VIM HNRNPK MAG MAP2K4 MAP4 MBP NAP1L1 NEFL PACSIN1 PCLO PRKACA PRKCG RUFY3 RYR2 SEPT3 SLC17A7 SLC1A3 SNAP25 SNAP47 SNAP91 SOD1 SRCIN1 SYNCRIP TPM3 UCHL1 VIM GO:0045202 synapse 10.0000 10.0000 10.0000 ACTN1 ARHGEF2 ATP2B2 BCAN ARHGEF2 ATP1A1 ATP6V0D1 BIN1 ADD1 ATP1A1 ATP6V0D1 BIN1 BIN1 BSN CADPS CAMK2A CANX CAP2 CTNND2 CYFIP1 GRIA1 MFF CANX CPLX1 FUS GIT1 GRIA2 CTNND2 CYFIP1 CYFIP2 DCLK1 MGLL RAB3B RAB3C SLC17A7 KCNAB2 KCTD12 MAP4 MFF PDE2A DNM1L FUS GIT1 GRIA2 GRM3 SNAP25 STX1A PICALM PRKACA RIMS1 RPH3A GRM5 HNRNPK KCTD12 MADD RTN4 SEPT3 SNAP25 SNCA STX1B MAP4 MYH9 NIPSNAP1 PACSIN1 PCLO PICALM PRKACA PRKCG PRRT2 RIMS1 SEPT3 SLC17A7 SLC1A3 SNAP25 SNAP47 SNAP91 SRCIN1 GO:0098793 presynapse 10.0000 10.0000 10.0000 BIN1 BSN CADPS CAMK2A DNM1L ATP6V0D1 BIN1 GRIA1 MFF RAB3B ATP6V0D1 BIN1 CPLX1 GRIA2 GRIA2 GRM3 KCTD12 MADD RAB3C SLC17A7 SNAP25 STX1A KCTD12 MFF PDE2A PICALM RIMS1 PACSIN1 PCLO PICALM RIMS1 RPH3A SEPT3 SNAP25 SNCA SEPT3 SLC17A7 SNAP25 SNAP47 STX1B SNAP91 GO:0044463 cell projection part 10.0000 10.0000 10.0000 ACTN1 AP3B2 ARHGEF2 ARPC1A AP3B2 ARHGEF2 ARPC1A ATP1A1 ADD1 ARPC1A ATP1A1 ATP6V0D1 BIN1 BSN CAMK2A CANX CLU ATP6V0D1 BIN1 CAP2 GRIA1 MAG BIN1 CANX CPLX1 FUS GPRIN1 DCLK1 FUS GRIA2 GRM3 GRM5 MAP2K1 MGLL PDXP PRKAR2A GRIA2 KCNAB2 KIF1A KIF5C MAP4 HNRNPK MAG MAP2K4 MAP4 MBP RUFY3 SIRT2 SNAP25 PICALM PRKACA PRKAR2A RTN4 NEFL PACSIN1 PCLO PDXP PFKM SNAP25 SNCA SOD1 PICALM PRKACA PRKCG RUFY3 SLC1A3 SNAP25 SNAP91 SOD1 SRCIN1 SYNCRIP TPM3 UCHL1 GO:0043209 myelin sheath 10.0000 10.0000 10.0000 ASS1 ATP1B1 ATP5F1 CANX DLAT ATP1A1 MAG MOG NDUFS1 SEPT8 ALB ATP1A1 CANX EEF1A2 GOT2 GFAP GNB2 GOT2 HSPA5 MAG SIRT2 SNAP25 SOD2 IDH3A NDUFA10 NDUFS1 RTN4 MBP NDUFA10 NDUFS1 NEFL SNAP25 SOD1 UQCRC1 PACSIN1 PDCD6IP PDIA3 PLCB1 SLC25A12 SNAP25 SOD1 TAGLN3 TCP1 TPPP UCHL1 UQCRC1 UQCRC2 GO:0030054 cell junction 10.0000 10.0000 5.6039 ACTN1 ACTN4 ALCAM ARHGEF2 ALCAM ARHGEF2 ATP1A1 CTNND2 ADD1 ATP1A1 BSG CALR CORO1B ATP1B1 ATP2B2 BSG BSN CADPS CYFIP1 GRIA1 HYOU1 MAP2K1 MFF GIT1 GRIA2 HYOU1 KCNAB2 CALR CAMK2A CORO1A CORO1B PDXP PRKAR2A RPL7 RPS2 RUFY3 KCTD12 MFF PRKAR2A RIMS1 CTNND2 CYFIP1 CYFIP2 DNM1L SIRT2 SLC17A7 SNAP25 STX1A RPH3A SEPT3 SNAP25 SNCA VIM GIT1 GNB2 GRIA2 HNRNPK HSPA5 KCTD12 MYH9 PACSIN1 PCBP2 PCLO PDCD6IP PDIA3 PDXP PRKCG PRRT2 RIMS1 RPL7 RUFY3 SEPT3 SLC17A7 SNAP25 SRCIN1 VIM GO:0030424 axon 10.0000 10.0000 5.3003 ALCAM AP3B2 BIN1 BSN CAMK2A ALCAM AP3B2 ATP6V0D1 BIN1 ATP6V0D1 BIN1 CANX CPLX1 CANX CORO1A GRIA2 GRM3 GRIA1 MAG MAP2K1 MGLL RUFY3 GRIA2 KCNAB2 KIF1A PDE2A HNRNPK MAG MAP2K4 MBP NEFL SIRT2 SLC17A7 SNAP25 SNAP25 SNCA SOD1 VIM PACSIN1 PCLO RUFY3 SLC17A7 SNAP25 SNAP91 SOD1 SRCIN1 UCHL1 VIM GO:0031410 cytoplasmic vesicle 10.0000 4.8905 10.0000 ACTN1 ACTN4 AP3B2 ARHGEF2 AP3B2 ARHGEF2 ATP1A1 ATP1B3 ALB ATP1A1 ATP1B3 ATP6V0D1 BIN1 BSG CADPS CALR CAMK2A ATP6V0D1 BIN1 GRIA1 HYOU1 MFF BIN1 BSG CALR CANX GRIA2 CAMKV CANX CLU CORO1A CTSB RAB3B RAB3C SLC17A7 SNAP25 HYOU1 MFF NAP1L1 PICALM DNM1L GRIA2 HSPA5 MADD STX1A RPH3A RPN1 SNAP25 SNCA SOD1 NAP1L1 PACS1 PACSIN1 PCLO STX1B TF PDCD6IP PDIA3 PICALM RPN1 SLC17A7 SLC3A2 SNAP25 SNAP91 SOD1 TCP1 GO:0097708 intracellular vesicle 10.0000 4.8832 10.0000 ACTN1 ACTN4 AP3B2 ARHGEF2 AP3B2 ARHGEF2 ATP1A1 ATP1B3 ALB ATP1A1 ATP1B3 ATP6V0D1 BIN1 BSG CADPS CALR CAMK2A ATP6V0D1 BIN1 GRIA1 HYOU1 MFF BIN1 BSG CALR CANX GRIA2 CAMKV CANX CLU CORO1A CTSB RAB3B RAB3C SLC17A7 SNAP25 HYOU1 MFF NAP1L1 PICALM DNM1L GRIA2 HSPA5 MADD STX1A RPH3A RPN1 SNAP25 SNCA SOD1 NAP1L1 PACS1 PACSIN1 PCLO STX1B TF PDCD6IP PDIA3 PICALM RPN1 SLC17A7 SLC3A2 SNAP25 SNAP91 SOD1 TCP1 GO:0008021 synaptic vesicle 4.7590 10.0000 10.0000 BIN1 DNM1L GRIA2 MADD PICALM ATP6V0D1 BIN1 GRIA1 MFF RAB3B ATP6V0D1 BIN1 GRIA2 MFF PICALM SLC17A7 SNAP25 SNAP91 RAB3C SLC17A7 SNAP25 STX1A RPH3A SNAP25 SNCA STX1B GO:0070382 exocytic vesicle 4.4540 10.0000 10.0000 BIN1 DNM1L GRIA2 MADD PICALM ATP6V0D1 BIN1 GRIA1 MFF RAB3B ATP6V0D1 BIN1 GRIA2 MFF PICALM SLC17A7 SNAP25 SNAP91 RAB3C SLC17A7 SNAP25 STX1A RPH3A SNAP25 SNCA STX1B GO:0033267 axon part 10.0000 5.7071 5.1658 AP3B2 BIN1 GRIA2 HNRNPK MAG AP3B2 ATP6V0D1 BIN1 GRIA1 MAG ATP6V0D1 BIN1 CPLX1 GRIA2 MBP NEFL PACSIN1 PCLO SNAP25 MGLL SIRT2 SNAP25 KCNAB2 KIF1A SNAP25 SNCA SNAP91 SOD1 UCHL1 SOD1 GO:0099503 secretory vesicle 5.7935 4.8400 10.0000 ACTN1 ACTN4 BIN1 BSG CALR CLU ATP6V0D1 BIN1 GRIA1 MFF RAB3B ALB ATP6V0D1 BIN1 BSG CALR DNM1L GRIA2 MADD PDIA3 PICALM RAB3C SLC17A7 SNAP25 STX1A GRIA2 MFF PICALM RPH3A SNAP25 SLC17A7 SNAP25 SNAP91 SOD1 SNCA SOD1 STX1B TF TCP1 GO:0060076 excitatory synapse 10.0000 4.1207 5.8048 ARHGEF2 BSN CAMK2A CTNND2 ARHGEF2 ATP1A1 CAP2 CTNND2 ADD1 ATP1A1 GRIA2 KCNAB2 DCLK1 GRIA2 GRM3 GRM5 GRIA1 SLC17A7 MAP4 PICALM RIMS1 RTN4 STX1B HNRNPK MAP4 PCLO PICALM PRKCG RIMS1 SLC17A7 SNAP91 SRCIN1