Current Pharmacologic Treatments of Irritable Bowel Syndrome
IFFGD International Foundation for PO Box 170864 Milwaukee, WI 53217 Functional Gastrointestinal Disorders www.iffgd.org Medications (168) © Copyright 2002-2015 by the International Foundation for Functional Gastrointestinal Disorders Updated by IFFGD, 2015 Current Pharmacologic Treatments of Irritable Bowel Syndrome By: Tony Lembo, M.D., Associate Professor, Beth Israel Deaconess Medical Center, Harvard Medical School, MA, and Rebecca Rink, M.S. [This article reviews indications, methods of action, and side small intestine and colon, thereby increasing stool bulk. effects associated with commonly available agents used to When the recommended dosage is used, it takes treat IBS. Any product taken for a therapeutic effect should approximately 1 to 2 days for osmotic laxatives to take be considered as a drug. Use medications, whether effect. The most common poorly absorbed ions used in prescription or over-the-counter, herbs, or supplements laxatives are magnesium and phosphate. carefully and in consultation with your doctor or healthcare When these laxatives enter the intestine, only a small provider.] percentage of magnesium or phosphate is actively absorbed. The remaining magnesium or phosphate in the intestine Pharmacologic treatments for IBS are aimed at improving the creates an osmotic gradient along which water enters the predominant symptoms such as diarrhea, constipation, and intestine. Phosphate is better absorbed in the intestine than abdominal pain. The most common classes of drugs currently magnesium, so it takes a substantial dose of phosphate used are laxatives, antidiarrheals, antispasmodics, and laxative to induce the osmotic effect. antidepressants. Laxatives Nonabsorbable carbohydrate laxatives (sorbitol and A laxative is a medication that increases bowel function. lactulose) are partially broken down by bacteria into There are four main classes of laxatives: fiber, osmotic compounds that cause water to accumulate in the colon, laxatives, stimulant laxatives, and emollients.
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