R Graphics Output

Gene Set 457 : MAPKPATHWAY Gene Set Null Distribution Heat Map for Genes in Gene Set G1[B_ETV6] G2[Non_B_ETV6] Class MAPK13 MAP3K11 MEF2C RPS6KA2 MAPK14 MAP4K2 Gene Set Null Density MAPK3 MAPK6 6 RAF1 Observed Gene Set ES value MAP3K9 0.2 MAPK7 RPS6KB2 MAP4K3 TGFBR1 HRAS MAP2K2 RIPK1 MAP3K13 MAP4K4 5 MAPK4 IKBKB RELA RPS6KA4

0.0 ELK1 MAP2K6 MAP4K1 MAP3K3 NFKBIA TGFB1 MAP3K10

4 CREB1 MAP2K5 MAPK10 MAPK11 DAXX BRAF TGFB2

−0.2 TGFB3 MAPKAPK3 MKNK2 MAPKAPK2

3 MAP2K7 Zero crossing at 6480 MAPK8 MKNK1 MAP3K2 Peak at 11155 P(ES) RPS6KA5 MAP3K8 MAP2K4 TRADD RAC1

−0.4 ATF2 MAP3K12 TRAF2 2 PAK2 SP1 GRB2 MAPK12 MAPKAPK5 MAP3K7 MAP4K5 PAK1

Running Enrichment Score (RES) MAP3K14 MEF2D

−0.6 JUN 1 SHC1 CHUK MEF2A MAP3K1 STAT1 MAP2K1 NFKB1 RPS6KB1 FOS MAP3K6 MAP2K3 0 CEBPA

−0.8 MAP3K5 MAX MAPK9 Neg. ES "G2[Non_B_ETV6]" Pos. ES: "G1[B_ETV6]" MAP3K4 "G1[B_ETV6]" "G2[Non_B_ETV6]" RPS6KA3 MAPK1 RPS6KA1 MYC

0 2000 4000 6000 8000 10000 12000 −0.4 −0.2 0.0 0.2 0.4 swp350.u133a.CEL JD.ALD096.v5.U133A.CEL JD.ALD108.v5.U133A.CEL JD.ALD509.v5.U133A.CEL JD.ALD057.v5.U133A.CEL JD.ALD232.v5.U133A.CEL JD.ALD294.v5.U133A.CEL JD.ALD385.v5.U133A.CEL JD.ALD052.v5.U133A.CEL JD.ALD078.v5.U133A.CEL JD.ALD433.v5.U133A.CEL JD.ALD180.v5.U133A.CEL JD.ALD009.v5.U133A.CEL JD.ALD388.v5.U133A.CEL JD.ALD428.v5.U133A.CEL JD.ALD494.v5.U133A.CEL JD.ALD035.v5.U133A.CEL JD.ALD039.v5.U133A.CEL JD.ALD391.v5.U133A.CEL JD.ALD264.v5.U133A.CEL JD.ALD386.v5.U133A.CEL JD.ALD387.v5.U133A.CEL JD.ALD389.v5.U133A.CEL JD.ALD390.v5.U133A.CEL JD.ALD008.v5.U133A.CEL JD.ALD613.v5.U133A.CEL JD0059.ALL.v5.U133A.CEL JD0123.ALL.v5.U133A.CEL JD0056.ALL.v5.U133A.CEL JD0058.ALL.v5.U133A.CEL JD0139.ALL.v5.U133A.CEL JD0107.ALL.v5.U133A.CEL JD0109.ALL.v5.U133A.CEL JD0085.ALL.v5.U133A.CEL JD0253.ALL.v5.U133A.CEL JD0426.ALL.v5.U133A.CEL JD0286.ALL.v5.U133A.CEL JD0282.ALL.v5.U133A.CEL JD0318.ALL.v5.U133A.CEL JD0066.ALL.v5.U133A.CEL JD0016.ALL.v5.U133A.CEL JD0048.ALL.v5.U133A.CEL JD0086.ALL.v5.U133A.CEL JD0193.ALL.v5.U133A.CEL JD0280.ALL.v5.U133A.CEL JD0320.ALL.v5.U133A.CEL JD0330.ALL.v5.U133A.CEL JD0328.ALL.v5.U133A.CEL JD0181.ALL.v5.U133A.CEL JD0239.ALL.v5.U133A.CEL JD0032.ALL.v5.U133A.CEL JD0361.ALL.v5.U133A.CEL JD0336.ALL.v5.U133A.CEL JD0267.ALL.v5.U133A.CEL JD0323.ALL.v5.U133A.CEL JD0150.ALL.v5.U133A.CEL JD0250.ALL.v5.U133A.CEL JD0220.ALL.v5.U133A.CEL JD0304.ALL.v5.U133A.CEL JD0395.ALL.v5.U133A.CEL JD0341.ALL.v5.U133A.CEL JD0263.ALL.v5.U133A.CEL JD0364.ALL.v5.U133A.CEL JD0437.ALL.v5.U133A.CEL JD0436.ALL.v5.U133A.CEL JD0382.ALL.v5.U133A.CEL JD0354.ALL.v5.U133A.CEL JD0342.ALL.v5.U133A.CEL JD0238.ALL.v5.U133A.CEL JD0247.ALL.v5.U133A.CEL JD0264.ALL.v5.U133A.CEL JD0390.ALL.v5.U133A.CEL JD0423.ALL.v5.U133A.CEL JD0432.ALL.v5.U133A.CEL JD0344.ALL.v5.U133A.CEL JD0039.ALL.v5.U133A.CEL JD0255.ALL.v5.U133A.CEL JD0421.ALL.v5.U133A.CEL JD0408.ALL.v5.U133A.CEL JD0080.ALL.v5.U133A.CEL JD0084.ALL.v5.U133A.CEL JD0124.ALL.v5.U133A.CEL JD0284.ALL.v5.U133A.CEL JD0349.ALL.v5.U133A.CEL JD0396.ALL.v5.U133A.CEL JD0108.ALL.v5.U133A.CEL JD0146.ALL.v5.U133A.CEL JD0360.ALL.v5.U133A.CEL JD0367.ALL.v5.U133A.CEL JD0314.ALL.v5.U133A.CEL JD0420.ALL.v5.U133A.CEL JD0343.ALL.v5.U133A.CEL JD0173.ALL.v5.U133A.CEL JD0258.ALL.v5.U133A.CEL JD0287.ALL.v5.U133A.CEL JD0103.ALL.v5.U133A.CEL JD0425.ALL.v5.U133A.CEL JD0225.ALL.v5.U133A.CEL JD0433.ALL.v5.U133A.CEL JD0431.ALL.v5.U133A.CEL JD0252.ALL.v5.U133A.CEL JD0188.ALL.v5.U133A.CEL JD0272.ALL.v5.U133A.CEL JD0289.ALL.v5.U133A.CEL JD0407.ALL.v5.U133A.CEL JD0257.ALL.v5.U133A.CEL JD0095.ALL.v5.U133A.CEL JD0226.ALL.v5.U133A.CEL JD0154.ALL.v5.U133A.CEL JD0206.ALL.v5.U133A.CEL JD0102.ALL.v5.U133A.CEL JD0129.ALL.v5.U133A.CEL JD0192.ALL.v5.U133A.CEL JD0260.ALL.v5.U133A.CEL JD0036.ALL.v5.U133A.CEL JD0381.ALL.v5.U133A.CEL JD0203.ALL.v5.U133A.CEL JD0246.ALL.v5.U133A.CEL JD0274.ALL.v5.U133A.CEL JD0334.ALL.v5.U133A.CEL JD0186B.ALL.v5.U133A.CEL JD0185B.ALL.v5.U133A.CEL JD0332.R.ALL.v5.U133A.CEL JD0168.B.ALL.v5.U133A.CEL JD0297.R.ALL.v5.U133A.CEL JD0300.RR.ALL.v5.U133A.CEL JD0291.RR.ALL.v5.U133A.CEL Gene List Index ES Number of genes: 12930 (in list), 84 (in gene set) ES = −0.289 NES = −1.22 Nom. p−val= 0.154 FWER= 1 FDR= 0.448