Curriculum Vitae MARC A. ILIES, Ph. D. ______Office Address: Temple University School of Pharmacy Department of Pharmaceutical Sciences 3307 North Broad Street, Suite 517 Philadelphia, PA-19140 Phone: 215-707-1749 ; Fax: 215-707-5620 Email: [email protected]

PRESENT POSITION: Associate Professor Director of the NMR facilities of TU School of Pharmacy Member of the Moulder Center for Drug Discovery Member of the Temple Materials Institute Associate Member of the Center for Targeted Therapeutics and Translational Nanomedicine of the University of Pennsylvania

EDUCATION

NRSA/NIH Postdoctoral fellow, University of Pennsylvania Health System, Department of (2006-2007); Mentors: Professors Vladimir Muzykantov and Ian Blair

Postdoctoral fellow, University of Pennsylvania, Department of Chemistry (2004- 2006); Mentor: Professor Virgil Percec

Welch postdoctoral fellow, Texas A&M University, Galveston, TX, and Visiting scientist, University of Texas Medical Branch at Galveston, TX; (2001-2004); Mentors: Professors Alexandru T. Balaban, William A. Seitz, and E. Brad Thompson

Ph. D., Chemistry, University “Politehnica” Bucharest, Romania, 2001 Thesis title: “Novel pyrylium and pyridinium salts with biological activity” Adviser: Professor Alexandru T. Balaban F. Rom. Acad. Sci. (presently Professor at Texas A&M University at Galveston, Galveston, TX)

M. S., Chemistry, University of Bucharest, Bucharest, Romania, 1996 Advisers: Professor Pierre Grandclaudon (ENSCL Lille, France) & Professor Ovidiu Maior (University of Bucharest)

B. S., Chemistry, University of Bucharest, Bucharest, Romania, 1995

Baccalaureate, Natural Sciences High School, Brasov, Romania, 1989

PROFESSIONAL AND ACADEMIC APPOINTMENTS

2014 – present Associate Professor, Department of Pharmaceutical Sciences, Temple University School of Pharmacy (TUSP); 2008 - present Director of NMR facilities, Temple University School of Pharmacy; 2007 – 2014 Assistant Professor, Department of Pharmaceutical Sciences, Temple University School of Pharmacy (TUSP); 2004 – 2007 Postdoctoral fellow, University of Pennsylvania, Philadelphia, PA; 2003 – 2004 Visiting Scientist, University of Texas Medical Branch at Galveston, TX, Department of Biochemistry and Molecular Biology; Marc A. Ilies PhD Page 1 of 10 Oct 2014 Curriculum Vitae 2001 – 2004 Postdoctoral fellow, Texas A&M University, Galveston, TX; 1998 – 2001 Junior Assistant Professor (2000 – 2001), Research scientist and Instructor (1998 – 2000), University of Agricultural Sciences and Veterinary Medicine Bucharest, Romania, Faculty of Biotechnology, Department of Chemistry; 1996 – 2000 Research scientist, National Institute for Research and Development in Electrochemistry and Condensed Matter, Bucharest, Romania;

HONORS AND AWARDS

- member of the American-Romanian Academy of Arts and Sciences – since 2014 - member of Temple Materials Institute – since 2010 - elected in Rho Chi Pharmacy Honor Society - 2008 - NRSA/NIH Fellowship 2006-2007 (Cancer Pharmacology); - Training Scholarship in Molecular Modeling and Combinatorial Chemistry from International Centre for Science and High Technology Trieste, Italy (I.C.S.-U.N.I.D.O.) 1999; - M. Sc. Scholarship from Government of France – 1996 IInd place in the M. Sc. Francophone Teaching Module – University of Bucharest, 1995 - finalist of Romanian National Chemical Olympiads 1986, 1987, 1988, 1989; 3rd Prize 1986; member of the Romanian National Chemistry Team 1986-1987

SUPERVISORY AND TEACHING EXPERIENCE Courses taught:

At Temple: Pharm. D. Program

- Medicinal Chemistry 151 (Biochemistry) Course Coordinator - Medicinal Chemistry 251 - Medicinal Chemistry 152

Ph. D. Program (Pharmaceutical Sciences)

- Introduction to Drug Design/Advanced Medicinal Chemistry (PS8009) - Advanced Drug Delivery Systems (PS8584) Course Coordinator - Biochemistry (PS8131) Course Coordinator

Before Temple: - 2003 organic chemistry laboratory course (lecturer) – Texas A&M University;

- 1998- 2001 organic chemistry laboratory course - University of Agricultural Sciences and Veterinary Medicine, Bucharest;

- 1998- 2001 inorganic chemistry laboratory course - University of Agricultural Sciences and Veterinary Medicine, Bucharest;

- 1997-1998 organic chemistry laboratory course – Polytechnic University of Bucharest, Faculty of Industrial Chemistry, Department of Organic Chemistry

Marc A. Ilies PhD Page 2 of 10 Oct 2014 Curriculum Vitae

Mentoring Post-doctoral fellows: Bogdan Draghici PhD (January 2013 – present)

Graduate Advising

Ph. D. Students: Sushma Savarala (TU College of Science and Technology, co-advised with Dr. Stephanie Wunder, January 2008 – December 2011; thesis defended 11/15/11) Suleyman Akocak (with Full Scholarship from Government of Turkey); TUSP (September 2009 – September 2014; thesis defended 07/24/14) Vishnu Dutt Sharma TUSP, (September 2010 – May 2014; thesis defended 04/28/14); received the annual Gautieri Award of TUSP and a TU Dissertation Grant

Utpal Kumar Mondal; TUSP, (September 2013 – present) Rajesh Kishore Kumar; TUSP, (September 2013 – present) Uttam Satyal; TUSP, (September 2013 – present) Rakibul Alam; TUSP, (September 2013 – present) Ahmed Shabana; TUSP, (September 2013 – present)

Rotations: Obioma Chikwendu; TUSP, (March 2008 – October 2010) Arjun Karla; TUSP (September 2009 – January 2010)

Pharm. D. Students: Kun Lee (PY1, TUSP), January 2013- present Lisa Dragic (PY1, TUSP), September 2012 – present Tiffany Sommers (PY2, TUSP), June 2009 – June 2010 Ramzan Ali (PY1, TUSP), March 2010- June 2010 Horng Mian (PY1, TUSP), October 2011-November 2011

M. Sc. Students: Khyati Dave (Jan – Dec 2008), presently at Merck and Co. Mrudang Shah (March- July 2008), presently at Wayne State U, PhD program

Research Technicians: Benjamin Duy Tran (Nov 2010 – Feb 2011)

Undergraduate Advising

2014-2015 Harry S. Thompson (TU CST – Biochemistry) Hanan Naser (TU CST – Biology)

2013-2014 Mallorie Fouch (TU CST – Biochemistry) Kayla D. Kownurko (TU Cellular and Molecular Neuroscience) Harry S. Thompson (TU CST – Biochemistry)

2012-2013 Han Nguyen (TU CST – Chemistry) James Grivas (TU CST – Biology)

2011-2012 Julia Lees (TU CST - Chemistry) Lisa Dragic (TU CST – Biology)

Marc A. Ilies PhD Page 3 of 10 Oct 2014 Curriculum Vitae Adrian Kizewski (TU CST – Biochemistry) was admitted in the PhD program of the Department of Pharmacology, Johns Hopkins University Andrew Gaspari (TU CST – Biochemistry) Kara Thompson (TU CST –Biology)

2010-2011 Adrian Kizewski (TU CST – Biochemistry) Andrew Gaspari (TU CST – Biochemistry)

2009-2010 Adrian Kizewski (TU CST – Biochemistry) Bhumiben Shah (TU CST – Biochemistry) Kyle Norris (TU CST- Chemistry) Eronmwon Aifuwa (TU CST- Chemistry) Huishu Xu (TU CST-Chemistry) Ahn Nguyen (TU CST-Chemistry) Li Ching He (TU CST-Biology)

2008-2009 Huishu Xu (TU CST-Chemistry, with Dr. Stephanie Wunder) Ahn Nguyen (TU CST-Chemistry, with Dr. Stephanie Wunder) Mydung Le (TU CST-Chemistry, with Dr. Stephanie Wunder) Dushyant Javia (TU CST-Chemistry, with Dr. Stephanie Wunder) Samson Russom (TU-PCC Bridge program) Lauren Spearman (PSTP Program)

2000- 2001 Nicolae Foldesi (BSc Thesis, USAMV Bucharest) Adrian Popa (BSc Thesis, USAMV Bucharest) Cristina Bacanu (BSc Thesis, USAMV Bucharest)

1997 teacher for the Romanian Olympic Team preparing for The International Chemistry Olympiad – Montreal, Canada;

RESEARCH INTERESTS

Bio-organic & medicinal chemistry/chemical biology at membrane interfaces: - heterocyclic chemistry and drug design: selective carbonic anhydrase inhibitors and activators, molecular markers for hypoxia and/or cancer, development of theranostic agents for combined therapy and diagnostic purposes. Our goal is to understand and exploit the role of carbonic anhydrase isozymes in the hypoxic tumor microenvironment and in the brain for development of anticancer and nootropic agents; - pyridinium derivatives: synthesis, physicochemical and biological properties, with a focus on their use in drug and gene delivery systems and towards the generation of novel biomarkers and theranostic systems; - supra-molecular chemistry and materials sciences, nanotechnology: synthesis, self- assembling, physicochemical and biological properties of assemblies of amphiphilic molecules of different molecular weights and packing parameters: surfactants, gemini surfactants, lipophilic oligomeric surfactants, lipids, dendrons, polymers; interfacial engineering for controlling the above-mentioned properties, drug and gene loading and delivery, enzymatic degradation, toxicity and loading of metallic nanoparticles (composite systems) for improved tracking/imaging capabilities, synergetic delivery and stabilization; - basic tissue engineering: spheroid cultures, understanding the tumor microenvironment in relation with oxygen/hypoxia and the role of carbonic anhydrases in tumor metabolism and development, establishment of 2D/3D correlations for streamlining in vitro/in vivo translation of drug and gene delivery systems. Marc A. Ilies PhD Page 4 of 10 Oct 2014 Curriculum Vitae

INVITED LECTURES

2014 248th ACS National Meeting, San Francisco, CA, (Division of Colloid and Surface Chemistry): “Modulation of self-assembling of pyridinium cationic amphiphiles for enhanced gene delivery” August 10 - August 14, 2014; 2014 "Interfacial engineering of pyridinium amphiphiles in self-assembled gene delivery systems", Drexel University, Department of Chemistry, April 24th 2014; 2014 Thermal Analysis Forum of the Delaware Valley 2014, at ASTM International: "Thermal analysis of self-assembled systems of gemini surfactants, lipids and polymers: Implications in drug and gene delivery", March 13th, 2014; 2013 University of Pennsylvania, Center for Targeted Therapeutics and Translational Nanomedicine Symposium: “Interfacial engineering of pyridinium amphiphiles in self-assembled gene delivery systems”, November 12th 2013; 2013 Institut de Chimie de Substances Naturelles, Gif-sur-Yvette, FR “Pyridinium drug and gene delivery systems”, October 28th 2013; 2013 2nd Satellite Meeting on Carbonic Anhydrases, Naples, IT, “Recent advances in CA inhibitor and activator design”, 23-25 October 2013; 2013 University of Pennsylvania, Center for Targeted Therapeutics and Translational Nanomedicine: “Enhancing the transfection efficiency of pyridinium gemini surfactants through interfacial engineering”, April 17th 2013; 2013 245th ACS National Meeting, New Orleans, LA, (Division of Colloid and Surface Chemistry): “Enhancement of cationic lipid - DNA complex properties by gemini surfactants and its impact in gene delivery”; I also received an invitation to allow the organizers to record the presentation and post it on ACS website; 2013 “Thermotropic self-assembling of novel pyridinium gemini surfactants” Thermal Analysis Forum of Delaware Valley Symposium, ASTM International, March 14th 2013; 2012 244th ACS National Meeting, Philadelphia, PA (Division of Colloid and Surface Chemistry): “Compaction of DNA on silica-supported cationic lipid bilayers”; 2012 244th ACS National Meeting, Philadelphia, PA (Division of Colloid and Surface Chemistry): “Dramatic enhancement of transfection efficiency of pyridinium gemini surfactants through interfacial engineering”; recorded and posted online at ACS website: http://presentations.acs.org/common/presentation- detail.aspx/Fall2012/COLL/COLL12A/20355 2012 “Pyridinium group – a versatile moiety for targeting carbonic anhydrase isozymes”, 9th International Conference on Carbonic Anhydrases, Antalya, TR, April 11-16, 2012. 2012 “Pyridinium amphiphiles: Synthesis, self-assembling, physicochemical and biological properties”, Selcuk University, TR, April 9th 2012; 2012 “Self-assembling in bulk and in solution of novel pyridinium amphiphiles” Thermal Analysis Forum of Delaware Valley Symposium, ASTM International, March 20th 2012; 2011 “Drug and Gene Delivery with Pyridinium Compounds” Department of Chemistry, CUNY- Lehman College, November 30th 2011; 2011 242nd ACS National Meeting, Denver, CO (Division of Colloid and Surface Chemistry): “Interaction of pyridinium surfactants with cellular membranes: Relevance to nucleic acid delivery”; Marc A. Ilies PhD Page 5 of 10 Oct 2014 Curriculum Vitae 2011 241st ACS National Meeting, Anaheim, CA (Division of Colloid and Surface Chemistry): “Modulation of lipoplex physicochemical properties and surface chemistry to enhance and target genetic material delivery to malignancies”; 2010 239th ACS National Meeting, San Francisco, CA (Division of Colloid and Surface Chemistry): “Structure-activity relationships throughout several classes of pyridinium-based amphiphilic compounds for gene delivery”; 2009 237th ACS National Meeting, Salt Lake City, UT (Division of Colloid and Surface Chemistry): “Impact of linker design and hydrophobic domain on physicochemical characteristics and transfection ability of pyridinium cationic lipids, gemini surfactants, and lipophilic polycations for gene delivery”; 2008 “Bridging the Broad Street’ Seminar Series, Temple University, Department of Chemistry: ”Synthetic self-assembling amphiphiles for drug and gene delivery” 2007 234th ACS National Meeting, Boston, MA (Division of Polymer and Material Science and Engineering): “Cell adhesion molecules-targeted polymeric worm micelles as selective in vivo drug delivery systems against endothelial cells” 2004 227th ACS National Meeting, Anaheim, CA (Division of Colloid and Surface Chemistry): “Lipophilic pyrylium salts in the synthesis of pyridinium-based cationic lipids and gemini surfactants for gene transfer” 2002 University of Florence, Florence, IT, Department of Chemistry: “Pyridinium Group – A Versatile Moiety in Drug Targeting”; 2001 University of Florence, Florence, IT, Department of Chemistry: “Selective Carbonic Anhydrase Inhibitors and Activators”; 2000 Calimanesti-Caciulata, Romania: 24th Romanian National Chemical Conference (with international participation) “Pyridinium Carbonic Anhydrase Inhibitors with Selectivity Against Membrane-Bound Isozyme CA IV”

TRAINING COURSES, STAGES, SUMMER SCHOOLS

- Philadelphia, PA (2006) X-Ray Scattering Course - Galveston, TX (2003) – Supervisor Development Program, at Texas A&M University Galveston - Trieste, Italy (1999) - training course “Combinatorial Chemistry and Combinatorial Technologies”, International Centre for Science and High Technology (I.C.S.-U.N.I.D.O.). - Lille, France (1996) - Master Stage with Prof. Pierre Grandclaudon, Laboratory of Organic and Physical Chemistry, Ecole Nationale Superieure de Chimie de Lille, France; - Bucharest, Romania (1995) - training course “2D-NMR” - Prof. Andre Thevand (Universite de Marseille) during the Francophone Teaching Module; - Bucharest, Romania (1995) - training course “Utilisation of Sulfur Derivatives in Organic Synthesis by Means of Stabilized Anions” - Prof. Pierre Grandclaudon (ENSCL, Lille, France) during the Francophone Teaching Module; - Sibiu, Romania (1994) - summer school “Peak Techniques In Molecular Biology”, organized by Ecole Normale Superieure de Paris and University of Bucharest;

MEMBERSHIP IN PROFESSIONAL SOCIETIES

- American (since 2001) - American Society of Gene Therapy (since 2004) - Controlled Release Society (2007-2008) - American Association of Colleges of Pharmacy (2007) Marc A. Ilies PhD Page 6 of 10 Oct 2014 Curriculum Vitae - Rho Chi Honor Society (since 2008) - American Association of Pharmaceutical Scientists (since 2008)

PUBLICATION, PATENTS (> 1100 citations, H-Index = 21)

- 51 scientific papers in peer-reviewed journals (see list of publications) - 4 book chapters - 2 laboratory manuals - 1 US Patent

INTERNATIONAL CONFERENCES AND CONGRESSES

- Oxford, UK (1995): Vth International Congress On Carbonic Anhydrases; - Brasov, Romania (1995): The International Congress on Nuclear Magnetic Resonance; - Lille, France (1996): “Journees Francophones des Jeunes Physico - Chimistes”; - Brasov, Romania (1997): International Conference on Imaging NMR Spectrometry; - Neptun, Romania (1998): “Modern Spectrometric Techniques in Biophysics”; - Halkidiki, Greece (1999): First International Conference of Balkans' National Chemical Societies; - Calimanesti-Caciulata, Romania (1999): XXVth National Chemical Conference (with international participation); - Calimanesti-Caciulata, Romania (2000): XXVIth National Chemical Conference with international participation - Boston, MA (2001): Drug Discovery Technology 2001; - Houston, TX (2001): The Welch Conference 2001; - Galveston, TX (2002): Symposium of Structural Biology 2002; - Houston, TX (2002): The Keck/GCC 2002 Bioinformatics Symposium; - Santa Clara, CA (2002): Biophex/Interphex 2002; - Houston, TX (2002): The Welch Conference 2002; - New Orleans, LA (2003): 225th ACS National Meeting; - Galveston, TX (2003): Symposium of Structural Biology 2003; - Houston, TX (2003): The Welch Conference 2003; - Anaheim, CA (2004): 227th ACS National Meeting; - Galveston, TX (2004): Symposium of Structural Biology 2004; - Minneapolis, MN (2004): American Society of Gene Therapy’s 7th Annual Meeting; - Philadelphia, PA (2004): 228th ACS National Meeting; - St. Louis, MO (2005): American Society of Gene Therapy’s 8th Annual Meeting; - Baltimore, MA (2006): American Society of Gene Therapy’s 9th Annual Meeting; - Long Beach, CA (2007): Controlled Release Society National Meeting; - Boston, MA (2007): 234th ACS National Meeting; - Boston, MA (2008): American Society of Gene Therapy’s 11th Annual Meeting; - Philadelphia, PA (2008): 236th ACS National Meeting; - Atlanta, GA (2008): AAPS National Meeting; - Salt Lake City, UT (2009): 237th ACS National Meeting; - Washington, DC (2009): 238th ACS National Meeting; - San Francisco, CA (2010): 239th ACS National Meeting. - Washington, DC (2010): American Society of Gene and Cell Therapy’s 13th Annual Meeting; - New Orleans, LA (2010): AAPS National Meeting. - Anaheim, CA (2011): 241st ACS National Meeting. Marc A. Ilies PhD Page 7 of 10 Oct 2014 Curriculum Vitae - Denver, CO (2011): 242nd ACS National Meeting - Washington, DC (2011): AAPS National Meeting; - Antalya, TR (2012): 9th International Conference on Carbonic Anhydrases - Philadelphia, PA (2012): 15th American Society of Gene & Cell Therapy Annual Meeting - Philadelphia, PA (2012): 244th ACS National Meeting - Chicago, IL (2012): AAPS National Meeting - New Orleans, LA (2013): 245th ACS National Meeting - Mount Snow, VT (2013): Gordon Research Conference on Cancer Nanotechnology - Naples, IT (2013): 2nd Satellite Carbonic Anhydrase Conference - San Francisco, CA (2014): 248th ACS National Meeting - Waterville Valley, NH (2014): Gordon Research Conference on Drug Carriers in Medicine & Biology

SERVICE ACTIVITIES

Intramural:

TU School of Pharmacy - Director of the TUSP NMR facilities (created by a joint initiative TUSP & Provost‘s Office) - daily maintenance of our Bruker AVANCE III 400 MHz NMR (June 2009 – present) - Curriculum Committee (2011) - Disciplinary Committee (Nov 2010) - Hiring/Search Committees for Medicinal Chemistry Associate Professor and Research Assistant Professor positions in TUSP (2010) - Merit Committee (2009, 2011) - Safety Committee (2009-present) - 2010 Research Day Organizing Committee (Feb 2010) - Teaching & Evaluation Committee (2008-present; 2011: I have evaluated my colleague Patrick McDonnell teaching for his promotion folder) - Wyeth Lecture Series Committee (2007) - Hiring/Search Committees for Medicinal Chemistry Associate Professor and Research Assistant Professor positions in TUSP - Accreditation Committee for standards 24-26 (Faculty and Staff Quantitative and Qualitative Factors, Continuing Professional Development and Performance Review) - PY4 Focus Group facilitator (2012) - generated feed-back from the PharmD students on what they think about PharmD curriculum once they have completed the program - Task Force for Graduate Curriculum improvement (2011, 2012) - PharmD class of 2016 faculty advisor

Temple University - External/internal PhD thesis evaluator: - Rajesh Raman Madathingal, (Adviser Stephanie Wunder PhD, CST-Chemistry) - Selver Ahmed (Adviser Stephanie L. Wunder PhD, CST-Chemistry) - Sivakumar Annadurai (Adviser Daniel J. Canney PhD, Pharmaceutical Sciences, TUSP) - Sushma Savarala (Adviser Stephanie L. Wunder PhD, CST-Chemistry) - Swapnil Singh (Adviser Scott Sieburth PhD, CST-Chemistry) Marc A. Ilies PhD Page 8 of 10 Oct 2014 Curriculum Vitae - Manali Phadke (Adviser Evgenyi Krinetzky PhD, Pharmaceutical Sciences, TUSP) - Richie Bhandare (Adviser Daniel J. Canney PhD, Pharmaceutical Sciences, TUSP) - Bharat S. Wagh (Adviser Rodrigo Andrade PhD, CST-Chemistry) - Preliminary PhD Exam/PhD Committee member: - Amit Bansal (Adviser David Lebo PhD, Pharmaceutical Sciences, TUSP) - Manali Phadke (Adviser Evgeny Krynetzkiy PhD, Pharmaceutical Sciences, TUSP) - Sivakumar Annadurai (Adviser Daniel J. Canney PhD, Pharmaceutical Sciences, TUSP) - Richie Bhandare (Adviser Daniel J. Canney PhD, Pharmaceutical Sciences, TUSP) - Seth Forster (Adviser Ho-Lun Wong PhD, Pharmaceutical Sciences, TUSP) - Pharmacy/Chemistry Intercollegial “Bridging the Broad Street” Research Seminar Program (2007-present, with Dr. Jonathan Shackman, CST-Chemistry) - 2012 Temple Annual Graduate Fellows Symposium Faculty Discussant - 2013 Temple Undergraduate Research Program Symposium Judge

Extramural: - reviewer for Proceedings of the National Academy of Sciences of USA (National Academy of Sciences), Journal of The American Chemical Society, Journal of Medicinal Chemistry, Biomacromolecules, Journal of Chemical Information and Modeling, ACS Combinatorial Science (ACS), Biomaterials, Bioorganic & Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Journal of Inorganic Biochemistry, Tetrahedron Letters (Elsevier), Medicinal Research Reviews, Chemical Biology and Drug Design, Journal of Pharmaceutical Sciences, (Wiley Interscience), RCS Advances, Organic and Biomolecular Chemistry, MedChemComm, ChemComm, Molecular BioSystems, , Polymer Chemistry Biomaterials Science (Royal Society of Chemistry), Journal of Carbohydrate Chemistry (Taylor & Francis), Current Medicinal Chemistry, Current Enzyme Inhibition, Anti-Infective Agents in Medicinal Chemistry (Bentham Sciences), Structural Chemistry, Colloid & Polymer Science (Springer Verlag), Journal of Enzyme Inhibition and Medicinal Chemistry (Informa) Arkivoc (Arkat USA), and Future Medicine (Future Science) journals; - patent reviewer for Expert Opinion on Therapeutic Patents journal (Informa, Ashley Pubs.); - voluntary consultant for Royal Society of Chemistry Roadmap. - Faculty of 1000 reviewer (Pharmacology and Drug Discovery) one evaluation done with graduate student Suleyman Akocak ranked number 8 in the “Pharmacology & Drug Discovery Hidden Jewels Top 10” - grant reviewer: - Research Corporation for Science Advancement, Tucson, AZ - Cottrell College Science Award Applications, - Oak Ridge Institute for Science and Education, - Natural Sciences and Engineering Research Council of Canada (NSERC) - external book reviewer for American Society of Health-System Pharmacists- Acquisitions and Special Publishing Department (book “Concepts in Medicinal Chemistry”) - Regional Editor for the U.S. for Open Journal of Enzyme Inhibition Marc A. Ilies PhD Page 9 of 10 Oct 2014 Curriculum Vitae - member of the editorial board for: Journal of Enzyme Inhibition and Medicinal Chemistry (Informa Healthcare), – 2011: 1.617, 5-Year Impact Factor: 1.507, http://informahealthcare.com/enz, Medicinal Chemistry , (Omics Publishing), Clinical and Experimental Pharmacology (Omics Publishing Group).

Marc A. Ilies PhD Page 10 of 10 Oct 2014