MOLECULAR AND CELLULAR BIOLOGY VOLUME 10 DECEMBER 1990 * NUMBER 12 Alan M. Weiner, Editor in Chief (1995) Anita K. Hopper, Editor (1994) J. Sherr, Editor (1995) Yale University The Milton S. Hershey Medical Center Howard Hughes Medical Institute Newv Haven, Conn. Pennsylvania State University St. Jude Children's Research Hospital Hershey, Pa. Memphis, Tenn. Lawrence A. Chasin, Editor (1995) Columbia University Tony Hunter, Editor (1993) Barbara Sollner-Webb, Editor (1995) News York, N. Y. The Salk Institute The Johns Hopkins University San Diego, Calif. School of Medicine David A. Clayton, Editor (1995) Baltimore, Md. Steven L. McKnight, Editor (1992) Stanford University School of Medicine Shirley M. Stanford, Calif. Carnegie Institution of Washington Tilghman, Editor (1993) Baltimore, Md. Princeton University Don W. Cleveland, Editor (1994) Princeton, N.J. The Johns Hopkins University Randy W. Schekman, Editor (1992) Owen N. Witte, Editor (1993) Baltimore, Md. University of California Institute Berkeley, Calif. University of California Angeles, Calif. EDITORIAL BOARD Frederick W. Alt (1990) Robert N. Eisenman (1991) Elizabeth Lacy (1990) Naomi E. Rosenberg (1991) Susan Berget (1990) Sarah C. R. Elgin (1991) Alan Lambowitz (1990) Rodney Rothstein (1990) Arnold J. Berk (1991) Scott Emr (1991) Lester F. Lau (1992) Norman P. Salzman (1991) Alan Bernstein (1990) Walton L. Fangman (1991) Michael Lenardo (1991) Paul Schedl (1990) Barbara K. Birshtein (1990) Thomas D. Fox (1990) Arthur D. Levinson (1990) Milton J. Schlesinger (1992) J. Michael Bishop (1990) Mary-Jane Gething (1990) Susan Lindquist (1990) Matthew P. Scott (1992) Elizabeth H. Blackburn (1991) Stephen P. Goff (1992) Douglas Lowy (1990) Arthur Skoultchi (1991) Jef D. Boeke (1991) Jack F. Greenblatt (1991) Paul T. Magee (1991) Frank Solomon (1991) Michael R. Botchan (1990) Rudolf Grosschedl (1992) James Manley (1992) Michael B. Sporn (1991) David Botstein (1990) Leonard P. Guarente (1991) Kunihiro Matsumoto (1991) Allan C. Spradling (1991) Bruce P. Brandhorst (1990) Christine Guthrie (1992) Frank McCormick (1992) Karen U. Sprague (1992) Marjorie C. Brandriss (1991) James E. Haber (1990) Janet E. Mertz (1990) Pamela Stanley (1991) Rodrigo Bravo (1992) Hidesaburo Hanafusa (1992) N. Ronald Morris (1992) Nat .L. Sternberg (1992) Kathryn Calame (1991) Leland D. Hartwell (1990) Bernardo Nadal-Ginard (1990) Bruce Stillman (1991) Judith Campbell (1992) Nathaniel Heintz (1991) Paul Neiman (1992) Kevin Struhl (1992) Mario R. Capecchi (1990) Ari Helenius (1990) Joseph R. Nevins (1990) Kenneth D. Stuart (1991) John A. Carbon (1990) Steven Henikoff (1991) Carol Newlon (1991) Bill Sugden (1991) Marian Carlson (1992) Ira Herskowitz (1990) Mary Ann Osley (1990) Lawrence H. Thompson (1991) C. Thomas Caskey (1990) Alan Hinnebusch (1991) Harvey L. Ozer (1991) Geoffrey Wahl (1992) Nam-Hai Chua (1991) Michael J. Holland (1990) Mary Lou Pardue (1991) Randolph Wall (1992) Jonathan A. Cooper (1992) Greg Hollis (1990) David Patterson (1991) Peter Walter (1990) Nicholas Cowan (1990) Peter M. Howley (1991) Marvin R. Paule (1992) Jonathan R. Warner (1990) Elizabeth A. Craig (1991) Stephen H. Hughes (1992) Gianni Piperno (1991) Reed B. Wickner (1991) Thomas Curran (1991) Mark Johnston (1991) John R. Pringle (1991) Lewis T. Williams (1991) Mark Davis (1990) Katherine A. Jones (1992) Randall R. Reed (1992) Fred Winston (1991) Thomas Donahue (1992) Daniel Klessig (1992) Steven I. Reed (1991) Elton T. Young (1990) Gideon Dreyfuss (1990) Marilyn Kozak (1991) Jean-Paul Revel (1991) Michael Young (1991) Mary P. Edmonds (1990) Monty Krieger (1992) Jasper D. Rine (1991) Barbara H. Iglewski, Chairman, Publications Board Linda M. Illig, Managing Editor, Journals Patrick N. Lacey, Production Editor

Molecular and Cellular Biology (ISSN 0270-7306), a publication of the American Society for Microbiology, 1325 Massachusetts Ave., N.W., Washington, DC 20005-4171, is devoted to the advancement and dissemination of fundamental knowledge concerning the molecular biology of eucaryotic cells, of both microbial and higher organisms. Instructions to authors are published in the January issue each year; reprints are available from the editors and the Journals Division. The journal is published monthly, one volume per year. The nonmember subscription prices are $340 (U.S. and Canada) and $390 (foreign; air drop shipping) per year; single copies are $40. The member subscription prices are $43 (U.S. and Canada) and $93 (foreign; air drop shipping) per year; single copies are $10. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Journals Division, 1325 Massachusetts Ave., N.W., Washington, DC 20005-4171 (area 202 737-3600). Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing because of failure to report an address change or for issues "missing from files" will not be allowed. Second-class postage paid at Washington, DC 20005, and at additional mailing offices. POSTMASTER: Send address changes to Molecular and CellularBiology, ASM, 1325 Massachusetts Ave., N.W., Washington, DC 20005-4171. B*z ( Made in the United States of America. Printed on acid-free paper. MrnUr4fl ,j r4f#i I t Copyright © 1990, American Society for Microbiology. All Rights Reserved. The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the article may be made for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per-copy fee through the Copyright Clearance Center Inc., 21 Congress St., Salem, MA 01970, for copying beyond that permitted by Sections 107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Author Index

Abovich, Nadja, 6417 Fahrner, Timothy J., 6454 Knepel, Willhart, 6799 Rhoads, David B., 6491 Allen, Susan A., 6160 Fawell, Stephen E., 6607 Knowland, John, 6674 Richardson, Jane, 6257 All-Robyn, Jamie A., 6544 Fey, Georg H., 6181 Kralova, Jarmila, 6445 Rienhoff, Hugh Y., Jr., 6624 Anderson, Carl W., 6472 Follin, Anders, 6664 Krauter, K. S., 6765 Riley, Timothy E. W., 6664 Aplan, Peter D., 6426 Fraenkel, Dan G., 6389 Robertus, Jon D., 6257 Archambault, Jacques, 6123 Frankel, Arthur, 6257 Laird-Offringa, Ite A., 6132 Roeder, Robert G., 6204 Armstrong, Wendy, 6805 Friedman, Alan, 6264 Landfear, Scott M., 6785 Roesler, William J., 6264 Azizkhan, Jane Clifford, 6632 Friedman, Jeffrey M., 6700 Latchman, D. S., 6817 Rosbash, Michael, 6417 Friesen, James D., 6123 Lau, Lester F., 6769 Rosenberg, Martin, 6152 Babiss, Lee E., 6700 Frisch, Steven M., 6524 Lee, Kevin A. W., 6192 Rossiter, Belinda J. F., 6805 Baker, Matthew, 6730 Frontali, C., 6759 Lee, Sheng-Chung, 6642 Rothenberg, Ellen V., 6325 Bayley, Hagan, 6775 Fujii, Hiroshi, 6204 Lee, Thomas C., 6512 Rotter, Varda, 6565 Begley, C. Glenn, 6426 Lee, Y.-J., 6654 Bell, Jeffrey, 6730 Gallie, Brenda L., 6586 Lees-Miller, Susan P., 6472 Saatcioglu, Fahri, 6408 Belmaaza, Abdellah, 6613 Geissler, Edwin N., 6619 Legrain, Pierre, 6417 Sander, Chris, 6578 Benfield, Pamela A., 6533 Gilbert, David M., 6348 Lei, Huan-Yao, 6642 Sax, Christina M., 6813 Ben-Ze'ev, Avri, 6565 Gilboa, Eli, 6512 Levin, Henry L., 6791 Schappert, Keith T., 6123 Berget, Susan M., 6299 Gilmore, Thomas, 6244 Li, Xiaoxia, 6624 Schieven, Gary L., 6244 Bertness, Virginia, 6426 Goldfinger, Naomi, 6565 Liao, Warren S.-L., 6624 Sengupta, Piali, 6809 Beushausen, Sven, 6775 Gonzalez, Frank J., 6216 Liebman, Susan W., 6544 Sharpe, N. G., 6817 , Michael C., 6632 Graw, Sharon L., 6619 Lim, Moon Young, 6244 Shaulsky, Gad, 6565 Boeke, Jef D., 6791 Gurney, Austin L., 6264 Lindberg, Richard A., 6316 Shenk, Thomas, 6397 Botstein, David, 6690 Gusew, Nadine, 6613 Lindquist, Susan, 6362 Shuman, Jon, 6264 Bowen-Pope, Daniel F., 6781 Linz, J. E., 6654 Silver, G., 6765 Brookman, Kerry W., 6160 Ha, Ilho, 6335 Linzer, Daniel I. H., 6709 Simons, Kai, 6578 Brouillette, Suzanne, 6613 Habener, Joel F., 6799 Liu, Jinsong, 6264 Simske, Jeffrey S., 6769 Brown, Nina, 6544 Hamel, Paul A., 6586 Lou, Willard, 6460 Singer, Richard A., 6356 Hanson, Richard W., 6264 Lum, Lynette S. Y., 6709 Smiley, B. L., 6436 Caddle, Mark S., 6225, 6236 Hartwell, Leland H., 6554 Smith, Clayton A., 6512 Caligo, Maria Adelaide, 6805 Heguy, Adriana, 6204 Maldonado, Edio, 6335 Smith, Harold E., 6103 Carrano, Anthony V., 6160 Heintz, Nathaniel, 6225 Marquardt, Hans, 6244 Sorce, Lilly M., 6586 Carroll, Steven L., 6454 Heintz, Nicholas H., 6225, Martin, G. Steven, 6244 Stacey, Dennis W., 6683 Carter, Timothy, 6460 6236 Masson, Norma, 6192 Stack, Sean P., 6785 Casale, W. L., 6654 Herman, Brian, 6290 Maxson, Rob, 6730 Stadnyk, A. W., 6436 Chafitz, James, 6799 Herman, Paul K., 6742 McBurney, Michael W., 6445 Stanton, Brian R., 6755 Chang, Ching-Jin, 6642 Hobson, Grace M., 6533 McConnell, D. G., 6654 Stearns, Tim, 6690 Char, Bharat R., 6730 Hogben, Paul, 6596 McKenzie, Edward A., 6674 Stein, David A., 6785 Charles, Catherine H., 6769 Housman, David E., 6619 Meuth, Mark, 6805 Stiles, Charles D., 6781 Chartrand, Pierre, 6613 Howard-Peebles, Patricia N., Milbrandt, Jeffrey, 6454 Stuart, K., 6436 Chavrier, Philippe, 6578 6374 Mitchell, Aaron P., 6103 Su, Sophia S. Y., 6103 Chen, Dan, 6325 Hoyt, M. Andrew, 6690 Molloy, George R., 6533 Suen, Ting-Chung, 6306 Chen, Ding-Shinn, 6642 Hu, Mickey C.-T., 6141 Mons, B., 6759 Sullenger, Bruce A., 6512 Chen, Tung-Ti, 6642 Huang, Jianyi H., 6624 Morisaki, J. Hiroshi, 6524 Sultzman, Lisa A., 6709 Chen, Yuh-Ru, 6472 Huang, Zhi-Ming, 6283 Morrisey, Joanne, 6381 Sun, Ivon, 6460 Chung, Yang-Tsung, 6172 Huckle, William R., 6290 Myler, P. J., 6436 Suplick, Kathleen, 6381 Cochran, Brent H., 6809 Hung, Mien-Chie, 6306 Susek, Ronald E., 6362 Cohen, Brenda L., 6586 Hunter, Tony, 6316 Natori, Shunji, 6114 Swergold, Gary D., 6718 Cohen, Stanley N., 6348 Hurst, Helen C., 6192 Neigeborn, Lenore, 6103 Swick, Andrew G., 6632 Coligan, John, 6426 Nonaka, Masaru, 6283 Colin, Anita M., 6730 Isselbacher, Kurt J., 6491 Novak, Thomas J., 6325 Talerico, Melissa, 6299 Cortes, Patricia, 6335 Ivey-Hoyle, Mona, 6152 Nussmeier, Mariann, 6426 Tam, See-Ying, 6619 Cridland, Nigel A., 6674 Ten Hagen, Kelly G., 6348 Cross, Frederick R., 6482 Jambou, Robert C., 6632 O'Brien, Timothy P., 6769 Thatcher, Jack D., 6264 6759 Dailey, David, 6244 Janse, C., Ohta, Tsunetaka, 6491 Thompson, Larry H., 6160 Jat, Parmjit S., 6664 O'Malley, Bert W., 6607 Thorner, Jeremy, 6244 Dailey, Lisa, 6225, 6236 Gerald 6356 Darlington, Gretchen J., 6181 Johnston, C., Orkin, Stuart H., 6596 Trudel, Pierre, 6613 Jones, Nicholas C., 6664 Otaka, Eiko, 6544 Trumbly, Robert J., 6500 Davidson, Norman, 6141 Nicolas 6192 DeLeon, Susan, 6460 Jones, C., Tsai, Men-Hwei, 6683 Jones, Nigel J., 6160 Pace, T., 6759 Tsai, Ming-Jer, 6607 Desautels, Lyne, 6613 Todd S.-C., 6181 Parada, Luis F., 6755 de Wit, L., 6132 Juan, Tsai, Shin-Feng, 65% Park, Edwards A., 6264 Tsai, Sophia Y., 6607 Dore, E., 6759 Kahn, Jeanne W., 6632 Parker, Malcolm G., 6607 Drebot, Michael A., 6356 Kahn, Richard A., 6690 Pasco, David S., 6408 Driscoll, Suzanne E., 6103 Uemura, Hiroshi, 6389 Kanai, Akio, 6114 Perry, David J., 6408 Ungers, Grace E., 6512 Dy, Ruth C., 6290 Kaufman, Randal J., 6709 Phillips, Robert A., 6586 Earnshaw, William C., 6374 Keller, Elizabeth B., 6172 Piatigorsky, Joram, 6813 Vaidya, Akhil B., 6381 Earp, H. Shelton, 6290 Kelly, James, 6781 Pierani, Alessandra, 6204 Vandurova', Ivana, 6460 Elfferich, Peter, 6132 Kikkawa, Fumitaka, 6216 Ponzi, M., 6759 van der Eb, Alex J., 6132 Elliston, Jonathan F., 6607 Kimura, Shioko, 6216 Pratt, M. A. Christine, 6445 Veinot-Drebot, Lela M., 6356 Emr, Scott D., 6742 Kirsch, Ilan R., 6426 Prokop, Carol A., 6290 Velcich, Anna, 6273 Ezquerra, Angel, 6426 Klein-Hitpass, Ludger, 6607 Vingron, Martin, 6578 Klement, John F., 6813 Reid, Susan, 6755 Fagan, John B., 6408 Klemm, Dwight J., 6264 Reinberg, Danny, 6335 Wallenburg, John, 6613 ii AUTHOR INDEX MOL. CELL. BIOL.

Wang, Chiayeng, 6781 Wevrick, Rachel, 6374 Williams, Frederick E., 6500 Zerial, Marino, 6578 Wang, S.-Y., 6654 Whitelaw, Emma, 6596 Wilson, Deborah R., 6181 Zhao, Allan Zijian, 6730 Weaver, Daniel C., 6791 Wilde, Margaret D., 6181 Wilusz, Jeffrey, 6397 Ziff, Edward B., 6273 Weinert, Ted A., 6554 Willard, Huntington F., 6348, Wu, Barbara J., 6709 Weis, Lisa, 6335 6374 Welsh, Phil, 6257 Williams, D. G., 6817 Yu, Chun-Li, 6683 U.S. Postal Service STATEMENT OF OWNERSHIP, MANAGEMENT AND CIRCULATION Reqsred by 39 U.S.C 3685, tA. Title of Publicatton 1B. PUBLICATION NO. 2. Date of Filing

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PS Form 3526, Feb. im8 (SLet inneicoet on reverseJ \ AUTHOR INDEX VOLUME 10

Aaronson, Stuart A., 2749, Ayer, Donald E., 3635 Benfield, Pamela A., 4826, Borzillo, Gary V., 2703 5496 Ayer, Stephen, 3512 6533 Bos, Johannes L., 5857 Abate, Cory, 5532 Ayres, Merrill, 1680 Benincasa, Diana, 3277 Boshart, Michael, 3334 Abelson, John, 324 Azizkhan, Jane C., 2111 Ben-Levy, Rachel, 3683 Bosze, Zsuzsa, 2432 Abovich, Nadja, 6417 Azizkhan, Jane Clifford, 6632 Bennett, Jeffrey L., 2191 Both, Gerald W., 5187 Abraham, Lawrence J., 3483 Benseler, Fritz, 6046 Bothwell, Alfred L. M., 5150 Abraham, Ninan, 5197 Bentley, David L., 5388 Botstein, David, 223, 3163, Abrahamsen, Mitchell S., Babinet, C., 3185 Benton, Bret M., 353 6690 5525 Babiss, Lee E., 2027, 38%, Benvenisty, Nissim, 2418 Bouvet, P., 4123 Ackerman, Eric J., 3505 6700 Benyajati, Cheeptip, 3512 Bowen-Pope, Daniel F., 2237, Adam, Mohammed A., 4239 Baerson, Scott R., 842 Ben-Ze'ev, Avri, 6565 6781 Adams, Thomas H., 1815, Baeuerle, P., 1498 Berger, Franklin G., 760 Bozzoni, Irene, 2437 4912 Baeuerle, Patrick A., 1281 Berget, Susan M., 84, 5937, Bradley, Matthews O., 1545 Adolph, S., 3078 Baim, Steven B., 3343 6299 Bradshaw, Amy D., 3483 Aebersold, Ruedi H., 1818 Baker, Matthew, 6730 Bergman, Lawrence W., 5950 Brady, John N., 4192 Aguanno, Ann M., 3277 Baker, Richard E., 2458 Berko-Flint, Yehudit, 75 Brandl, Christopher J., 4256 Aguilera, Andrds, 1439 Baker, Suzanne J., 5772 Berlot, Cathy, 2931 Brannan, Camilynn I., 28 Ahmad, Suhail, 5160 Balcarek, Joanna M., 2678 Bernards, Rene, 2012 Brasier, Allan R., 1023, 4389 Ahn, Byung-Yoon, 5433 Baldari, Cosima T., 2731 Berns, Anton, 1452 Brawerman, George, 2060 Ahuja, Renu, 5160 Baldwin, Albert S., Jr., 1406 Bernstein, Alan, 474, 2521 Breitman, Martin L., 474 Akeson, Richard, 2012, 3314 Ballesta, Juan P. G., 2182 Bernstein, Kenneth E., 4294 Brene, Stefan, 4701 Akira, Shizuo, 2757 Ballester, Roymarie, 2539 Bertness, Virginia, 6426 Brenner, D. A., 689 Alarcon, Clara M., 2765 Bally-Cuif, Laure, 1959 Beru, Nega, 3591 Brennicke, Axel, 2428 Albright, C., 4612 Baltimore, David, 2327, 3155, Berwaer, Monique, 4690 Brennscheidt, U., 3325 Alcivar, Acacia A., 1828 5464 Besansky, Nora J., 863 Brennwald, Patrick, 2874 Alcorta, David A., 2413, 2787 Bandyopadhyay, Ram, 2060 Beushausen, Sven, 6775 Brent, Roger, 2840 Ali, Ahmad J., 1423 Bandyopadhyay, Sudip K., Beverley, Stephen M., 1084 Brentano, Steven T., 6013 Allan, Maggi, 1199, 1209, 4990 5055 Beyer, Ann L., 316 Brents, Leslie, 705 Allard, Michael F., 3709 Banerjee, Nanditta, 1373 Beyer, Eric C., 1754 Bressac, Brigitte, 5772 Allen, Susan A., 6160 Banerjee, Subhasis, 2863 Bhat, Narayan K., 1249 Brewer, Bonita J., 10 All-Robyn, Jamie A., 6544 Bannon, Gary A., 6091 Bhattacharyya, Nitai P., 3945 Brindle, Paul K., 4863, 4872 Alonso, Teresa, 3117 Banta, Lois M., 4638 Bianchi, Marco E., 2341 Briskin, Michael, 422 Al-Shawi, Raya, 1192 Bardwell, Vivian J., 295, 846 Biemann, Hans-Peter N., 2122 Brivanlou, Ali Hemmati, 3376 Alt, Frederick W., 1672, 1697, Barker, Douglas, 1452 Bihain, Bernard E., 4506 Brody, E., 5036 1799, 2096 Barker, Kathleen, 3813 Billis, William M., 442 Brookman, Kerry W., 6160 Altanchimeg, Rencendorj, Barlowe, Charles K., 5679 Birchenall-Roberts, Maria C., Brooks, Mary W., 4961 2432 Barnhart, Kerry M., 5958 4978 Brosset, S., 5865 Amaldi, Francesco, 430, 816 Baronas-Lowell, Diane M., Birkenmeier, Edward H., 5244 Brouillette, Suzanne, 6613 Amalric, Frangois, 430, 3607 5235 Bishop, J. M., 1000, 1835 Brouwer, Jaap, 4678 Amati, Bruno, 5442 Barrett, C. Brent, 310 Bishop, John O., 1192 Brown, Kenneth M., 4192 Ammendola, Rosario, 387 Barrett, John, 5914 Bishop, Sanford P., 3709 Brown, Laura G., 681 Amrein, Kurt E., 1853 Barriocanal, Javier G., 2294 Bisson, Linda F., 5903 Brown, Nina, 1017, 6544 Andersen, Janet, 4480 Barta, Endre, 2432 Biswas, Esther E., 810 Broxmeyer, Hal E., 4948 Anderson, Carl W., 6472 Baserga, Renato, 303, 3289 Biswas, Subhasis B., 810 Bruenn, Jeremy A., 1373 Andrianopoulos, Alex, 3194 Basilico, Claudio, 2475 Bjelfman, Catarina, 361 BrOlet, Philippe, 3801 Angel, Peter, 1492 Bateman, John F., 1452 Bjorge, Jeffrey D., 3280 Brun, Christine, 5455 Annex, Brian H., 5671 Battey, James F., 4180 Blackburn, Elizabeth H., 2070 Brun, Gilbert, 3584 Anraku, Yasuhiro, 2214 Baum, Mary P., 1863 Bladon, Trevor S., 4058 Bruns, Romaine, 1452 Antonarakis, Stylianos E., 930 Baumann, Heinz, 760, 1573, Blake, Michael C., 6632 Brunt, Shelley A., 273 Aplan, Peter D., 6426 3965, 5967 Blasband, Andrew, 2973 Buchberg, Arthur M., 4658 Applegate, Lee Ann, 4967 Baur, Markus, 492 Blasband, Andrew J., 2111 Buchhalter, Jeffery, 5586 Appling, Dean R., 5679 Bayley, Hagan, 6775 Blattner, Frederick R., 3690 Buchman, Andrew R., 887 Aquino, Angelo, 5541 Baylin, Stephen B., 1773 Blenis, John, 3204 Buchman, Carla, 4778 Araki, Hiroyuki, 1358 Beato, Miguel, 625 Bloom, Kerry, 5721 Buhler, Jean-Marie, 2049 Araki, Shin, 4116 Beck, P. J., 4612 Blumenthal, Thomas, 1764 Bull, Michael, 3792 Archambault, Jacques, 6123 Beck, T. W., 2503, 3325 Blusch, Jurgen, 4080 Bull, Paulina, 5473 Arguelles, Juan , 4518 Becker, Frederick F., 5728 Bocquel, Marie-Therese, 5002 Bumstead, Nat, 4788 Arheden, Kristina, 5408 Bedigian, Hendrick G., 4658 Boczko, Erik M., 38% Buratowski, Stephen, 5562 Armstrong, Barbara C., 4180 Begley, C. Glenn, 6426 Boeke, Jef D., 615, 2695, 6791 Burgess, Wilson H., 4770 Armstrong, Wendy, 6805 Belanger, Luc, 5002 Bogenmann, Emil, 5015 Burhans, William C., 4685 Arnemann, Jutta, 625 Belayew, Alexandra, 4690 Bokoch, Gary M., 2901 Burke, Joanne, 1192 Amos, Franqoise, 4431 Belenguer, Pascale, 3607 Bolen, Joseph B., 2035 Burke, Kathleen A., 3027 Aronoff, Rachel, 1891 Bell, J. B., 4379 Bona, Marion, 2738 Burkett, Thomas J., 2882 Arrigo, Andre-Patrick, 1276 Bell, Jeffrey, 6730 Bonapace, Ian Marc, 1033 Burnett, Jean B., 5114 Ashburner, Michael, 539 Bellofatto, Vivian, 3036 Bond, Jane A., 5365 Burns, Jorge S., 5365 Ashmun, Richard A., 2703 Bellot, F., 435 Boorstein, William R., 3262 Burstein, D. E., 2983 Ashraf, Javed, 5580 Belmaaza, Abdellah, 6613 Boothroyd, John C., 3284 Burstein, David E., 1556 Assoian, Richard K., 5983 Beltrame, Monica, 2341, 4737 Bootsma, D., 5806 Busch, Harris, 3253 Atkin, A. L., 4379 Benchimol, Samuel, 3307 Bootsma, Dirk, 2570 Bushel, Pierre, 1199, 1209, Avvedimento, Enrico V., 1033 Bender, Timothy, 5747 Borellini, Flavia, 5541 4990 Axelrod, Nancy J., 947 Bender, Timothy P., 705 Bortner, Donna M., 1 Bussey, Howard, 3013 i ii AUTHOR INDEX MOL. CELL. BIOL.

Butler, Darel A., 1153 Chen, Rey-Huei, 3204 Conrad, Susan E., 3834 de Barros Lopes, Miguel, Butler, J. Scott, 2599 Chen, Shiming, 5663 Cooper, Geoffrey M., 923, 2966 Byrne, Paul, 5663 Chen, Tung-Ti, 6642 5314, 5324 de Bruin, Derik, 3243 Chen, Xiaorong, 2111 Cooper, Jonathan A., 2528 de Bustros, Andrde, 1773 Caddle, Mark S., 6225, 6236 Chen, Yuh-Ru, 6472 Cooper, Terrance G., 3884, Deckelbaum, Richard J., 4506 Cai, Hong, 5314, 5324 Chen, Yunn-Yi, 1672 5087 Decker, Thomas, 2448 Caizergues-Ferrer, Michele, Chen, Z.-X., 3535 Copeland, Neal G., 501, 4658 Declerck, Nathalie, 4795 430, 3607 Chen, Zhi, 4555 Copeland, Terry D., 3137 Dedrick, Russell L., 593 Calderwood, Stuart K., 1234, Cheng, Alec, 5027 Corcoran, Lynn, 5464 Deeley, Roger G., 154 1600 Cheng, Jian, 5502 Cordle, Susan R., 1564 Dees, Elizabeth Claire, 28 Caligo, Maria Adelaide, 6805 Cheng, Jiu, 5215 Corley, Ronald B., 4211 DeFranco, Anthony L., 3003 Calothy, Georges, 3584 Cheng, Seng H., 5569 Cortes, Patricia, 6335 Deising, Holger, 1815 Canalis, Ernesto, 4473 Chen-Wu, Joan L.-P., 4089 Cortese, Ricardo, 2653 de Lange, Titia, 518 Canfield, Victor, 1367 Chester, Nicholas, 2539 Cortese, Riccardo, 387 DeLeon, Susan, 6460 Cantor, Charles R., 2863 Chibazakura, Taku, 4130 Corthdsy, Blaise, 3926 Della Seta, Flavio, 2437 Cao, Xinmin, 1931, 4243 Chisari, Francis V., 5728 Cortner, Janelle, 3788 Del Sal, G., 2924 Capone, J. P., 4974 Chiu, Choy-Pik, 4953 Costantini, Frank, 1116 Dent, C. L., 3258 Capra, J. Donald, 982 Choi, Paul M., 4650 Cote, Gilbert J., 84 DePamphilis, Melvin L., 1719, Carayannopoulos, Leon, 982 Choi, Y., 5822 Coulier, Francois, 4202 4685 Carlin, Cathleen R., 5521 Chorney, Michael J., 243 Courtois, Stephane J., 1811 DePinho, Ronald, 2096 Carlson, Louise, 3224 Chow, King-Lau, 528 Coutavas, Elias, 1793 Der, Channing J., 2901 Carlson, Marian, 1105, 2544, Christoph, Greg, 4406 Coutts, Margaret, 2060 Derby, Robert J., 3524 4744, 4935, 5616 Chua, Nam-Hai, 5565 Cox, David R., 518 Dermody, J. J., 5688 Carlstedt-Duke, Jan, 4712 Chung, Yang-Tsung, 206, 6172 Cox, Michael M., 235 Desautels, Lyne, 6613 Carmichael, Gordon G., 947 Ciafrd, Silvia-Anna, 2437 Crabeel, Marjolaine, 1226 Deshaies, Raymond J., 6024 Caron, Joan M., 1239 Ciardiello, Fortunato, 4027 Craig, Elizabeth A., 1622, De Simone, Vincenzo, 387 Carr, Cynthia S., 4384 Ciccarelli, Carmela, 1525 3232, 3262 DeTeresa, Patricia S., 401 Carrano, Anthony V., 6160 Cicirelli, Michael F., 458 Cridland, Nigel A., 6674 D'Eustachio, Peter, 1793 Carroll, Dana, 5849 Cieslinski, Lenora B., 2678 Croce, Carlo M., 4370 Devault, Alain, 1652 Carroll, Simon M., 4456 Ciliberto, Gennaro, 991 Cross, Frederick R., 6482 Dever, Thomas E., 1134 Carroll, Steven L., 6454 Cipriani, Ralph, 120 Cross, Sharon L., 850 Dewerchin, Marianne, 3541 Carter, Stephen G., 1822 Cladaras, Christos, 2653 Crouse, Gray F., 6003 de Wit, Carla L., 6132 Carter, Timothy, 6460 Claesson-Welsh, Lena, 801 Crouse, Joseph C., 6097 de Wit, J., 5806 Cartwright, Christine A., 361 Clark, Ira, 5927 Crow, David S., 1754 de Wit, Jan, 2570 Casadevall, Carmen, 303 Clark, Melody E., 5106 Crystal, Ronald G., 47 Dhanasekaran, N., 2931 Casale, W. L., 6654 Clark, Robin, 2901, 5977 Cuadrado, A., 2983 Dhar, Veena, 4324 Casimir, Colin M., 5388 Clarke, Catherine F., 2315 Cuadrado, Antonio, 6069 Diamond, Lisa E., 1265 Cassar, Evelyne, 4737 Clarke, Louise, 1863 Cuddy, Michael P., 4370 Diaz, J.-J., 4524 Celenza, John L., 1105 Clarke, Peter R. H., 5271 Culp, Lloyd A., 662 Dickson, Robert C., 2176, Centrella, Michael, 4473 Clarke, Steven, 5071 Cumsky, Michael G., 1873, 5128 Cerdan, Maria Esperanza, Clark-Walker, G. D., 1530 5510 Dieken, Ellen S., 4574 5921 Clayton, Christine E., 3036 Curatola, Anna Maria, 2475 Dietz, Thomas J., 4233 Chae, Chi-Bom, 585 Clayton, David A., 2191 Curiel, David T., 47 Di Fiore, Pier Paolo, 2749, Chafitz, James, 6799 Cleveland, Don W., 615 Curran, Tom, 4243, 5532 3247 Chalepakis, Georges, 625 Cleveland, J. L., 2503 Dikstein, Rivka, 3683, 4427 Chalkley, Roger, 2390, 3770, Cleveland, John L., 3325, Diller, Lisa, 5772 3782 3562 Dahl, Douglas, 1265 Diltz, Curtis D., 458 Chalupny, Jan, 1853 Coburn, Cara M., 1084 Dahlberg, James E., 3365 Di Marco, Eddi, 3247 Chambon, Pierre, 5002 Cochran, Brent H., 6809 Dailey, David, 6244 Di Nocera, Pier Paolo, 4667 Chamow, Steven M., 1507 Cockerill, Peter N., 1293 Dailey, Lisa, 6225, 6236 Dionne, Craig A., 4770 Chan, Edward K. L., 2164 Cocozza, Sergio, 1033 Damore, Michael, 422 Dircks, Lori K., 4984 Chan, Tung-On, 3280 Coffman, Robert, 1672 Dancis, Andrew, 2294 Disteche, Christine M., 1969 Chang, Ching-Jin, 6642 Cohen, Brenda L., 6586 D'Andrea, Alan D., 3675 Dixit, Vishva M., 5830 Chang, Chung-Der, 303, 3289 Cohen, Bruce, 2909 Dang, Chi V., 5914 Dixon, Wendy, 4778 Chang, Ling A., 5894 Cohen, Dalia, 3596 Dang, Qi, 5455 Doctor, John S., 3232 Chapman, John W., 1358 Cohen, Donna R., 4243 Daouk, Ghaleb H., 1476 Dodd, Jonathan, 2049 Chapman, Verne, 4987 Cohen, Hannah, 2418 Darlington, Gretchen J., 6181 Dolan, Kevin P., 3277 Char, Bharat R., 6730 Cohen, Lucie, 3987 Darnell, James E. , Jr., 1841, Donelson, John E., 2765 Charles, Catherine H., 6769 Cohen, Maurice, 4401 2448, 38% Donovan, David M., 3700, Charnay, Patrick, 3456 Cohen, Stanley N., 4345, 6348 Darrow, Andrew L., 5883 6097 Charron, Jean, 1799 Cole, Gary M., 510 Das, M. R., 2468 Doppler, Clemens, 5558 Charron-Prochownik, Denise Cole, Michael D., 1265 Dasgupta, Asim, 5106 Dorai, Thambi, 4068 C., 5333 Colicelli, John, 2539 Daub, Raymond, 4948 Dore, E., 2423, 6759 Chartrand, Pierre, 6613 Coligan, John, 6426 Dautry, F., 5865 Doree, Marcel, 3607 Chasles, Marion, 4795 Colin, Anita M., 6730 Davidson, Norman, 6141 Dorel, C., 4123 Chasman, Daniel I., 2916 Collart, Martine A., 1498 Davis, Christie T., 4996 Dorfman, David M., 4854 Chavrier, Philippe, 6578 Collins, Catherine, 4466 Davis, Ronald L., 2678 Dornburg, Ralph, 68 Chedid, Marcio, 3824 Collins, Steven J., 2154 Deagostini-Bazin, Hermine, Doss, Carol, 4007 Chen, Aoshuang, 3314 Collins, Tucker, 6051 1959 Doss, Lisa K., 3709 Chen, Dan, 6325 Compton, Debra, 1773 Dedk, Ferenc, 2432 Dostatni, Nathalie, 4431 Chen, Ding-Shinn, 6642 Condie, Brian G., 3376 Dean, Ann, 2247 Dotto, G. Paolo, 1164 Chen, Julia, 282 Connerton, Ian F., 2638 Dean, Jurrien, 1507 Downing, James R., 1664 Chen, K., 3105 Conquet, Francois, 3801 DeArmond, Stephen J., 1153 Drawbridge, Julie, 3994 VOL. 10, 1990 AUTHOR INDEX iii

Drebot, Michael A., 6356 Ezquerra, Angel, 6426 Fried, Mike, 605 Gitlin, Scott D., 4192 Driscoll, Suzanne E., 2104, Friedman, Alan, 6264 Gius, David, 4243 6103 Fagan, John B., 6408 Friedman, Jeffrey M., 6700 Givol, David, 6064 Drivas, George T., 1793 Fahrner, Timothy J., 6454 Friedman, Rosalind, 4978 Glansdorff, Nicolas, 1226 Dron, Michel, 854 Faktor, Ouriel, 3683, 4427 Friedman, Thomas B., 5114 Glaser, Robert L., 131 Druker, Brian, 2909 Falkenburg, J. H. Frederik, Friend, Stephen H., 5772 Glaser, Scott M., 1873 Dubois, Evelyne, 3541 4948 Friesel, Robert, 4770 Glass, Charles A., 2164 Dudley, J. P., 5822 Fan, Qian N., 341 Friesen, James D., 1217, 6123 Glazer, Robert I., 5541 Duester, Gregg, 5007 Fangman, Walton L., 10 Friesen, Paul D., 3067 Glimcher, Laurie H., 1347, Duigou, Gregory J., 2027 Farabaugh, Philip J., 947 Frisch, Steven M., 6524 1609 Dull, Thomas J., 3048 Farache, G., 5349 Frohlich, Mark, 3216 Glover, Claiborne V. C., 4089 Dunaway, Marietta, 2893, Faras, Anthony J., 3432 Frontali, C., 2423, 6759 Goddard, Colin, 4473 6055 Farnham, Peggy J., 653, 1390, Fu, Ying-Hui, 1056 Goff, Stephen P., 1799 Dunn, Ashley R., 4603 3788 Fueri, Josette P., 3036 Goldberg, Itzhak D., 4424 Dunn, John J., 353 Farrell, Francis X., 2349 Fujii, Hiroshi, 6204 Goldfinger, Naomi, 6565 Dunn, Stephanie M., 2950 Faure, Michel, 1921 Fujii-Kuriyama, Yoshiaki, Goldwasser, Eugene, 3591 Dunn, Teresa M., 2308 Fausto, N., 3185 1470 Gonzalez, Frank J., 4495, Dunnick, Wesley, 397 Fawell, Stephen E., 5529, Fujisawa-Sehara, Atsuko, 6216 Durbin, Russell K., 4529 6607 2562 Goodwin, Leslie O., 1729 Dureza, Raquel C., 930 Fazioli, Francesca, 2749 Fujita, Donald J., 3280 Goridis, Christo, 1959 Durviaux, Serge M., 1811 Fecker, , 2848 Fujiwara, Shigeyoshi, 1249 Gorman, Cornelia M., 1805 Duval, C., 4123 Feddersen, Rod M., 569 Fukui, Yasuhisa, 2855 Gorski, Jack, 3792 Duvall, Janet F., 4192 Feeney, Robert J., 4480 Furfine, Eric S., 3659 Goto, Koji, 958 Dy, Ruth C., 6290 Felsenfeld, Gary, 2774 Gottesdiener, Keith, 6079 Dynan, William S., 3635 Felts, Sara J., 2390 Gaber, Richard F., 643 Gottesfeld, Joel M., 5166 Feng, Junli, 1126 Gabriel, Abram, 615 Gottschalk, Lisa R., 5486 Earnshaw, William C., 6374 Ferrell, James E., Jr., 3020 Gaffney, Robert, 1931 Gounari, Fotini, 387 Earp, H. Shelton, 2973, 6290 Ferrer, Pierre, 430 Gagne, Elizabeth, 5532 Goux-Pelletan, Maria, 5036 Eberly, Susan L., 1358 Ferro-Novick, Susan, 3405 Gaillardin, Claude, 4795 Goyal, Neerja, 1041 Eckhardt, Laurel A., 1076 Fey, Georg H., 3483, 6181 Gallego, Maria E., 2133 Graf, Thomas, 2591 Eckstein, Fritz, 6046 Field, Jeffrey, 2539 Gallie, Brenda L., 6586 Grainger, James L., 3994 Edery, Isaac, 1134 Filvaroff, Ellen, 1164 Gallo, Adriana, 1033 Granner, Daryl K., 3357, Edington, Brent V., 4886 Fincham, John R. S., 2638 Galvin, Katherine, 3216 3770, 4712 Edman, Jeffrey C., 146, 4538 Fink, Gerald R., 643 Gangloff, Serge P., 3551 Grant, Barbara J., 2164 Edmonds, Mary, 846 Finley, Dan, 4905 Gangopadhyay, Suman B., Grant, Dana B., 3873 Edwards, Helen, 1633 Finley, Kim, 3663 193 Grant, Mark, 4987 Edwards, Peter A., 2315 Finley, Russell L., Jr., 5663 Garcia, Arnold, 2591 Graw, Sharon L., 6619 Efrat, Shimon, 1779 Fiorentini, Paola, 4667 Garcia-Anoveros, Jaime, 6079 Gray, Alane, 3048 Ehrlich, Kenneth C., 4957 Fischer, Edmond H., 458 Garfinkel, David J., 2882 Gray, Joe W., 401 Ehrlich, Melanie, 4957 Fischman, Kineret, 146, 5021 Garofalo, Silvio, 1033 Green, Janell M., 1969 Eichler, Duane C., 3868 Fisher, Paul A., 353 Garrity, Paul A., 5646 Green, Kenneth P., 341 Ek, Bo, 801 Fisher, Paul B., 2027 Gashler, Andrea, 1931 Green, Michael R., 1476 Ekblom, Marja, 2848 Fisher, Robert J., 1249 Gasser, Susan M., 5442 Green, Steven H., 1556 Ekblom, Peter, 2848 Fiszman, Marc Y., 5036 Gasson, J., 6084 Greene, John M., 1319 Elder, James T., 1382 FitzGerald, David J., 2443 Gaugler, Luc, 1959 Greer, Peter, 2521 Elder, Robert T., 2809 Fitzgerald, M. J., 3185 Gearhart, John D., 930 Grimaldi, Giovanna, 4667 Eldridge, Carol S., 5536 Fitzgerald, Mark, 3717 Gebhardt, Mark, 5772 Grindlay, G. Joan, 1209 Elfferich, Peter, 6132 Flanagan, James R., 3700 Geiser, Andrew, 4978 Groner, Bernd, 4027 Elgin, Sarah C. R., 4233 Fleischer, Norman, 1779 Geissler, Edwin N., 6619 Gronostajski, Richard M., Ellison, Eldora L., 3386 Flick, Jeffrey S., 4757 Gennissen, Annemieke, 4170 1041 Elliston, Jonathan F., 6607 Fogel-Petrovic, Mirjana, 5215 Gentile, Raffaele, 1033 Gros, Philippe, 1642, 1652, Emanuel, Janet Rettig, 1367 Follin, Anders, 6664 Gershon, Paul D., 5433 6036 Emr, Scott D., 4638, 6742 Forrester, William C., 1382 Gervais, Christian, 4412 Grosveld, Gerard, 4016 Eng, Wai-Kwong, 353 Forte, Michael A., 910 Gething, M.-J., 4612 Grotendorst, Gary R., 55% Engebrecht, JoAnne, 2379 Fournier, Maurille J., 1145 Gibbs, Jackson B., 1689 Groudine, Mark, 1382 Engelke, David R., 426 Fournier, Philippe, 4795 Gibson, Susan I., 5707 Grunstein, Michael, 2687, Engelman, Alan, 4365 Fournier, R. E. K., 2660, 3782 Giese, Neill, 5496 5721 Englund, Paul T., 720 Fox, Thomas D., 4590 Giger, Urs, 3268 Gruss, Peter, 4100 Enrietto, Paula J., 4788 Fraenkel, Dan G., 6389 Giguere, Vincent, 2335 Gryka, Magdalena A., 5772 Erikson, Eleanor, 2413 Frain, Monique, 991 Gilbert, David M., 4345, 6348 Gu, Yi-Zhong, 1784 Erikson, R. L., 2122, 2413, Frampton, J., 3838 Gilboa, Eli, 6512 Gubits, Ruth M., 3277 2787 Francis, Marilyn A., 4486 Gill, Grace, 681 Gudas, Jean M., 5591 Ernoult-Lange, Michele, 418 Frank, Reiner, 3456 Gillespie, Gerald A., 243 Gudas, Lorraine J., 391 Ernst, Mary, 4202 Franke, Jakob, 1921 Gillet, Germain, 3584 Guermah, Mohamed, 3584 Espino, Pearl C., 5569 Frankel, Arthur, 6257 Gilley, David, 1538 Guise, Kevin S., 3432 Estridge, J. K., 3258 Fraser, J., 6084 Gilliland, Gretchen K., 5536 Gunning, Peter W., 1095 Estruch, Francisco, 2544 Freeland, Thomas M., 5378 Gilmartin, Philip M., 5565 Guo, Zong-Sheng, 1719 Evan, Gerrard I., 4961 Freeman, Lita, 16 Gilmore, Reid, 449 Gupta, Radhey S., 5160 Evans, Claire F., 426 Fregeau, Chantal J., 4058 Gilmore, Thomas, 2840, 6244 Gupta, Shashi, 939 Evans, Janet L., 5747 Freistadt, Marion S., 5700 Gilmour, David S., 4233 Gupta, Sunil K., 2931 Ewen, Mark E., 3761 French, Randall P., 2081 Ginsberg, Idit, 1373 Gurney, Austin L., 6264 Exinger, F., 5257 Frick, Kevin K., 184 Giordano, Thomas J., 4529 Gusew, Nadine, 6613 Eyre, David, 1452 Fridell, Robert A., 1423 Giraldez, Fernando, 4110 Gustafsson, Jan-Ake, 4712 iv AUTHOR INDEX MOL. CELL. BIOL.

Gutierrez, Crisanto, 1719 Heguy, Adriana, 6204 Hopper, James E., 1415, 4623 Jans, Arnold W. H., 4518 Gutkind, J. Silvio, 3806 Heidecker, G., 2503 Horlick, Robert A., 4826 Janse, C., 6759 Guzman, Raphael C., 1593 Heidecker, Gisela, 3828 Horwitz, Susan Band, 35% Jat, Parmjit S., 6664 Gwynn, Babette, 5244 Heideman, Warren, 3873 Hougan, Linda, 217 Jay, Gilbert, 413 Heintz, Nathaniel, 6225 Housman, David E., 1600, Jaye, Michael, 4770 Ha, Ilho, 6335 Heintz, Nicholas H., 6225, 1642, 6619 Jenkins, Nancy A., 501, 4658 Haas, Martin, 5502 6236 Howard, Bruce D., 770 Jinno, Atsushi, 2261 Habener, Joel F., 1023, 4389, Held, W., 1373 Howard, Tom E., 4294 Johnson, Daniel E., 4728 6799 Heldin, Carl-Henrik, 801 Howard-Peebles, Patricia N., Johnson, David G., 982 Haber, James E., 2941 Helfman, David M., 1729 6374 Johnson, David L., 5950 Hache, Robert J. G., 154, 625 Hellmann, Utha, 5424 Hoy, C. A., 1584 Johnson, Edward M., 4899 Hack, Ethan, 3979 Henderson, Eva, 1564 Hoyt, M. Andrew, 223, 6690 Johnson, Gary L., 2931 Hackett, Perry B., 3432 Henderson, Sheryl L., 4816, Hozumi, Nobumichi, 5340 Johnson, Jeffrey J., 2081 Hadzopoulou-Cladaras, 4970 Hrachovy, Julie A., 3087 Johnson, Kyle, 1891 Margarita, 2653 Hendrickson, Eric A., 5397 Hrycyna, Christine A., 5071 Johnson, Lianna, 2687 Haffter, Pascal, 4590 Henly, John W., 10 Hsu, C.-L. L., 5822 Johnson, Paula A., 1828 Hagenbuchle, O., 254 Henning, Dale, 3253 Hsu, Stephen I-Hong, 3596 Johnston, Gerald C., 6356 Haidar, Mohammad A., 3253 Henseling, Ulf, 4100 Hu, Lan, 391 Johnston, Leland H., 1358 Hailstones, Deborah L., 1095 Hensold, Jack O., 1600 Hu, Mickey C.-T., 6141 Johnston, Mark, 4623, 4757 Hake, Laura E., 1828 Henthorn, Paula, 1382 Huang, Jianyi H., 3619, 6624 Jones, Elaine V., 5433 Haldar, Subrata, 4370 Herbst, Roy S., 3896 Huang, Manley T. F., 1805 Jones, J. E., 2983 Halden, Nancy F., 850 Hereld, Dale, 720 Huang, Zhi-Ming, 6283 Jones, Keith W., 5098 Hall, Anne L., 1921 Herman, Brian, 6290 Hubbard, Richard C., 47 Jones, Nicholas C., 6664 Hallberg, Richard L., 3979 Herman, Paul K., 4638, 6742 Huckle, William R., 6290 Jones, Nicolas C., 6192 Hamada, Kazushige, 3700 Hermine, Olivier, 3591 Hudson, Geoffrey, 3483 Jones, Nigel J., 6160 Hamaguchi, Michinari, 830 Herrero-Sanchez, Carlos, 965 Hughes, Stephen H., 3137 Jones, Patricia P., 593, 3906 Hamel, Paul A., 6586 Herrick, David, 2269 Hui, Chi-chung, 872 Jones, Steven W., 2413 Hamer, Dean, 418 Herrlich, Peter, 5857 Huleihel, M., 2503 Jones, Tania, 5365 Hamlin, Joyce L., 1338 Hershberger, Richard P., 662 Humphries, Caroline G., 3690 Josephs, Steven F., 5541 Hammerling, Ulf, 361 Herskowitz, Ira, 5927 Humphries, Eric H., 3224 Ju, Qida, 5226 Hammond, Craig, 1853 Herzenberg, Leonard A., 1697 Hung, Mien-Chie, 6306 Juan, Todd S.-C., 6181 Han, Tae-Hee, 138 Hicks, James B., 409 Hunt, Clayton R., 1600 Julius, Martin, 382 Hanafusa, Hidesaburo, 830, Hiebert, Scott W., 1989 Hunt, Jay D., 823 2855, 3813 Hiesel, Rudolf, 2428 Hunter, Tony, 2606, 2991, Kabrun, Neil, 4788 Hanahan, Douglas, 1779 Hieter, Philip, 4163 5473, 6316 Kaddurah-Daouk, Rima, 1476 Hanke, Jeffrey H., 982 Hightower, Lawrence E., Hurst, Helen C., 6192 Kadesch, Tom, 2619, 3145 Hann, Stephen R., 3952 4886 Huxley, Clare, 605 Kaelin, William G., Jr., 3761 Hanna, David E., 4089 Higuchi, Hiroshi, 3717 Hwang, Inhwan, 585 Kahn, Jeanne W., 6632 Hanson, Richard W., 480, Hill, Kathryn, 3013 Hwung, Young-Ping, 1784 Kahn, Richard A., 6690 6264 Hines, Victoria, 1399 Hyman, Robert, 4266 Kaiser, Chris A., 3163 Hanson, Robin D., 5655 Hinnebusch, Alan G., 2294, Hynes, Michael J., 3194 Kakuda, Donald, 3663 Hardon, Elizabeth, 991 2820 Hynes, Nancy E., 4027 Kaleko, Michael, 464 Harland, Richard M., 3376 Hirai, Hisamaru, 1307 Ibanez, Carlos, 2591 Kallestad, Jeffery, 1882 Harless, Michael L., 1484, Hirano, Toshio, 2757 Ibanez, Carlos E., 2285 Kalvakolanu, Dhananjaya V. 4555 Hirose, Fumiko, 872 Ihle, James N., 1259 R., 5055 Harrington, Maureen A., 4948 Hirsch, Marie-Rose, 1959 Iida, Naoko, 55% Kamata, T., 880 Harris, Joanna, 2973 Hirschfeld, Steven, 2041 Imai, Enyu, 4712 Kamens, Joanne, 2840 Harrison, P. R., 3838 Hirsh, David, 1769 Iman, Deborah S., 2027 Kamholz, John, 5586 Hartstein, Morris, 3596 Hiscott, John, 3987 Ingram, Robert S., 28 Kamiya, Hiroyuki, 1461 Hartwell, Leland H., 2202, Hishinuma, Fumio, 4130 Inman, Ross B., 235 Kamps, Mark P., 5464 6554 Ho, I-Cheng, 4720 Innis, Michael A., 4872, 5977 Kanai, Akio, 6114 Harvey, Robert, 5569 Ho, Jeong-Yau, 2966 Inoue, Kazushi, 1789 Kanamori, Akira, 486 Harwerth, Ina Maria, 4027 Hobson, Grace M., 4826, 6533 Ip, Y. Tony, 3770, 3782 Kanbe, Toshio, 2214 Hassan, Nassef F., 5586 Hockenberry, David, 1901 Isacke, Clare M., 2606 Kane, Jeffrey, 2582 Hassauer, Martin, 2738 Hodge, Martin R., 5510 Isselbacher, Kurt J., 6491 Kane, Patricia M., 3737 Hassin, David, 75 Hoeijmakers, J. H. J., 5806 Isshiki, Hiroshi, 2757 Kang, Seogchan, 5839 Hata, Yutaka, 4116 Hoeijmakers, Jan H. J., 2570 Itin, Ahuva, 5021 Kang, Yoon-Se, 2582 Hatfield, Dolph, 1940 Hoekstra, Merl F., 5473 Itzhaki, Jane E., 3036 Kanik-Ennulat, Cynthia, 898 Hatton, K. S., 4314 Hoffman, Brian L., 5521 Ivashkiv, Lionel B., 1347, Kaplan, David R., 2359 Hattori, Kazue, 1492 Hoffman, Rebecca K., 3268 1609 Kaplan, Gerardo, 5700 Hatzopoulos, Antonis K., Hoffmann, F. Michael, 2669 Ivey-Hoyle, Mona, 6152 Kaplan, J. M., 1000 4100 Hogben, Paul, 6596 Iwata, Kenneth K., 4473 Kapler, Geoffrey M., 1084 Hawley, Diane K., 5782 H6kfelt, Tomas, 4701 Kaplow, June, 4770 Hay, Rick V., 1931 Holland, Janice P., 4863, 4872 Jackson, Belinda M., 2820 Kapuscinski, Anne R., 3432 Hayman, Michael J., 4788 Holland, Michael J., 4863, Jackson, Catherine L., 2202 Kara, Catherine J., 1347, 1609 Haynes, Susan R., 316 4872 Jackson, Twila, 3709 Karby, Shulamit, 75 Hays, John B., 3505 Holmes, Edward W., 5271 Jacob, Samson T., 5177 Kardassis, Dimitris, 2653 Heasley, Lynn E., 2931 Holmes, Kevin L., 3562 Jacobs, Eric, 3541 Karin, Michael, 1492, 4778 Heberlein, Ulrike, 539 Holttfi, Erkki, 5814 Jacobson, Allan, 2269, 3441 Kasper, James, 4978 Hecht, Norman B., 1828 Holtzman, Douglas A., 4603 Jacobson, K. Bruce, 1940 Kass, Susan, 4920 Heffron, Fred, 1174 Holzman, Lawrence B., 5830 Jaenisch, Rudolf, 1452 Kassel, Jayne, 5772 Hefta, Laura J. F., 2738 Honegger, A. M., 435, 4035 Jahreis, Gerald P., 5967 Kato, Gregory J., 5914 Hegde, Ashok N., 2468 Hoodless, Pamela A., 154 Jambou, Robert C., 6632 Kato, Jun-ya, 2407 VOL. 10, 1990 AUTHOR INDEX v

Kato, Kazuto, 486, 2017 Klintworth, Gordon K., 474 Lamph, William W., 1609 Lester, Robert L., 2176 Kato, Nobuyuki, 4401 Kmetz, Peter, 2678 Land, Hartmut, 4%1 Leu, Tzeng-Horng, 1338 Katz, Richard A., 6% Knepel, Willhart, 6799 Landfear, Scott M., 6785 Lev, Sima, 6064 Katz, Wendy, 5286 Knicley, Charles L., 3247 Lane, Tracy, 2591 Levenson, Robert, 1367 Kaufman, Lon S., 842 Knight, Glenn B., 5591 Lang, Katharine M., 4942 Levin, Henry L., 6791 Kaufman, Randal J., 6709 Knowland, John, 6674 Langford, Kimberly G., 4294 Levin, Lonny R., 1066 Kaufman, Russel, 95 Knox, Jennifer, 1041 Lapeyre, Bruno, 430 Levine, Arnold J., 3343 Kavathas, Paula, 1853 Kobe, Suzanne S., 1754 LaRochelle, William J., 54% Levine, Arthur S., 2041 Kawai, Sadaaki, 3095 Kobr, Michel, 965 Latchman, D. S., 3258, 6817 Levine, Kathryn L., 1891 Kaziro, Yoshito, 4303 Koch, Norbert, 4146 Latimer, Jean J., 760 Levy, David E., 2448 Kazlauskas, Andrius, 2528 Koizumi, Shigeki, 1249 Lau, Alan F., 1754 Levy, Ronald, 4007 Kearsey, Stephen E., 265 Kolb, Janet M., 2049 Lau, Lester F., 3569, 6769 Levy, Shoshana, 4007 Kedar, Padmini S., 3852 Kolch, W., 2503 Laufer, Edward M., 4%1 Lewin, Alfred S., 1399 Kedes, Larry, 2402 Kolodziej, Peter A., 1915 Laugier, Danielle, 3584 Lewis, E. D., 1584 Kellems, Rodney E., 1484, Koltin, Yigal, 1373 Lauquin, Guy J.-M., 3551 Ley, Timothy J., 5655 4555 Kondo, Jun, 4116 Laurent, Brehon C., 1105, Li, Daijun, 5728 Keller, Elizabeth B., 206, Kondo, Naomi, 5340 5616 Li, Haodong V., 1145 6172 Kondoh, Hisato, 486, 958, Lauter, Frank R., 5064 Li, Suzanne C., 1672, 1697 Keller, Hans Joerg, 5166 2017 Lavalle, Robert, 1226 Li, Xiaoxia, 6624 Keller, Walter, 4942 Kondou, Shunzo, 4130 Lavi, Sara, 75 Liang, Li-fang, 1507 Kelly, James, 6781 Konieczny, Stephen F., 3934 Lavin, Martin F., 5279 Liao, Sha-Mei, 1915 Kemp, L. M., 3258 Kornberg, Roger D., 887, Law, Ronald, 422 Liao, Warren S. L., 3619, Kennady, P. Kavin, 1287 2916 Lawless, Denise, 1461 6624 Kenter, Amy L., 1714 Korsmeyer, Stanley J., 1901 Leach, R. J., 2660 Libermann, Towia A., 2327 Kerr, Lawrence D., 4284 Koski, Raymond A., 1931 Leavitt, John, 1818 Libermann, Towia Aron, 3155 Keshet, Eli, 5021 Kovari, lulia, 5087 Lebedev, Y. B., 3535 Libri, Domenico, 5036 Kessin, Richard H., 1921 Kovari, Ladislau, 5087 Leblanc, Jean-Francois, 3987 Lieberson, Rebecca, 1076 Kessler, Daniel S., 2448 Kozak, Christine A., 3663 Le Blancq, Sylvia, 3492 Liebman, Susan W., 1017, Keyse, Stephen M., 4967 Kozma, Lynn M., 837, 3626 LeBon, Jeanne M., 4987 6544 Khalili, Kamel, 5586 Kraft, Andrew S., 5536 LeBowitz, Jonathan H., 5464 Lillie, James W., 1476 Khan, Khuda Dad, 5150 Kralova, Jarmila, 6445 LeClair, Kenneth P., 1406 Lim, Kyu, 585 Khosla, Meenal, 918 Kramer, James M., 2081 Leder, Philip, 4406 Lim, Moon Young, 6244 Kielland-Brandt, Morten C., Kraus, Betsy, 4630 Ledwith, Brian J., 1545 Lin, Bertha B., 850 643 Krauter, K. S., 2625, 6765 Lee, Byeong J., 1940 Lin, Ching-Shwun, 1818 Kikkawa, Fumitaka, 6216 Kraynak, Andrew R., 1545 Lee, David C., 2111, 2973 Lin, Fwu-Lai M., 103, 113 Kikuchi, Akira, 2645, 4116 Krebs, Edwin G., 458 Lee, Frank, 4953 Lin, Jian-Xin, 3818 Killery, Ann M., 518 Kreider, Brent L., 4846 Lee, Gene W., 1982 Lin, Liang-In, 282 Kilpatrick, Daniel L., 3717 Kress, Michel, 418 Lee, Grace, 422 Lin, Michael C., 57 Kim, Chul G., 5958 Krimpenfort, Paul, 1452 Lee, Hy-De, 4978 Lin, Yi-Chaung, 382 Kim, Kyung Young, 1492 Krowczynska, Anna, 2060 Lee, Kevin A. W., 6192 Lindberg, Richard A., 6316 Kim, Rosalind, 5945 Kruckeberg, Arthur L., 5903 Lee, Kyu-Ho, 2237 Lindholm, Paul F., 4192 Kim, Seong-Jin, 1492, 4978 Krupitza, Georg, 4375 Lee, Mary Gwo Shu, 3492, Lindner, Ingrid J., 3727 Kim, Seung U., 5586 Krystal, Geoffrey W., 4180 4506, 6079 Lindquist, Susan, 6362 Kim, Shigekuni, 2645 Kuczek, Elizabeth S., 2950 Lee, Pauline L., 4728 Lindwall, Glen, 5150 Kim, Suil, 3224 Kudlow, Jeffrey E., 45% Lee, Ree Y., 1773 Linial, Maxine L., 1891 Kim, Sung-Hou, 5945 Kuehl, Michael, 422 Lee, Se-Jin, 3239 Linsley, Peter S., 1882 Kim, Yeong S., 1940 Kuehl, W. Michael, 705, 5747 Lee, Sheng-Chung, 6642 Linz, J. E., 6654 Kimmel, Alan R., 2367 Kumar, Ramesh, 4202 Lee, Tae H., 1982 Linzer, Daniel I. H., 6709 Kimura, Shioko, 6216 Kumar, Ravi, 3277 Lee, Thomas C., 6512 Liou, Hsiou-Chi, 1347, 1609 Kincade, Paul W., 422 Kung, H.-F., 880 Lee, William M. F., 4%1 Liou, Ruey-Fen, 1764 King, Leslie B., 4211 Kung, Hsiang-fu, 3828 Lee, Y.-J., 6654 Lipsick, Joseph, 2591 Kingston, Robert, 1476 Kung, Hsing-Jien, 3048 Lees, Jacqueline A., 5529 Lipsick, Joseph S., 2285 Kingston, Robert E., 165, 176, Kuo, M. Tien, 5728 Lees-Miller, James P., 1729 Lipson, Kenneth E., 3289 1319, 1600 Kurjan, Janet, 2582 Lees-Miller, Susan P., 6472 Lis, John T., 131, 3272, 6041 Kinnaird, Jane, 1192 Kurkinen, Markku, 2848 Leffert, H. L., 689 Littlewood, Trevor D., 4961 Kinzler, Kenneth W., 634, Kutsunai, Sally Y., 2315 Legouy, Edith, 2096 Litwak, Gregory, 5772 5408 Kwon-Chung, K. J., 4538 Legrain, Pierre, 6417 Liu, Jinsong, 480, 6264 Kipling, David, 265 Kwong, Jeffrey, 3397 LeGuellec, R., 4123 Liu, Xingquan, 5601 Kirchhausen, Tomas, 6089 Lei, Huan-Yao, 6642 Liu, Yuxi, 2909 Kirsch, Ilan R., 6426 Labbe, Jean-Claude, 3607 Leiden, Jeffrey M., 4720, 5486 Liu, Zhanjiang, 3432 Kirschner, Lawrence S., 35% Labow, Mark A., 3343 Leiting, Barbara, 3727 Livi, George P., 409, 2678 Kishimoto, Tadamitsu, 2757 Lacal, J. C., 2983 Leleiko, Neal S., 4356 Livingston, David M., 3761 Kiss, Ibolya, 2432 Lacal, Juan Carlos, 333 Lemaigre, Frederic P., 1811 Lloyd, P., 2503 Kitamoto, Katsuhiko, 2214 Lacal, Pedro M., 3806 LeMaire, Mimi F., 6059 Lo, Patrick C. H., 2492 Klamut, Henry J., 193 Lacasa, Michel, 854 Lemaire, Patrick, 3456 Lock, Peter, 4603 Klar, Amar J. S., 409 Lafontaine, Dominique A., Lemoine, Nick R., 5365 Lodish, Harvey F., 3675 Klausner, Richard K., 2294 1811 Lenardo, Michael, 3155 Loeb, Jonathan, 1680 Klein, Hannah L., 1439 LaForge, K. Steven, 5736 Lenardo, Michael J., 2950 Loh, Dennis Y., 5027 Klein, Rudiger, 4202 Lafyatis, Robert, 1492 Lengyel, Peter, 1822 Loh, Tatjana P., 4045 Klein-Hitpass, Ludger, 6607 Lai, Michael M. C., 5575 Leonard, Warren J., 850 Lois, Rodrigo, 16 Klement, John F., 6813 Laird-Offringa, Ite A., 6132 Leonnard, Philippe, 3926 Lonardo, Fulvio, 2749 Klemm, Dwight J., 480, 6264 Laloux, Isabelle, 3541 Lerach, Hans, 4016 London, Lucille, 1901 Klinken, S. Peter, 1293, 3562 Lamb, Robert A., 1989 Lesley, Jayne, 4266 Lopata, Margaret A., 4816 vi AUTHOR INDEX MOL. CELL. BIOL.

Losson, R., 5257 Martin-Zanca, Dionisio, 4202 Metzenberg, Robert L., 5839 Mueller, LeMoyne, 2154 Lothstein, Leonard, 3596 Maruya, Aiko, 2738 Meuth, Mark, 6805 Mueller, Susan G., 4596 Lou, Willard, 6460 Marzluf, George A., 1056 Meyer, Marc-Etienne, 5002 Mun, B., 5688 Love, Harold D., Jr., 6091 Mascara, Thomas, 1452 Meyerhardt, Jeffrey, 3717 Munemitsu, Susan, 3048, 5977 Lowe, D., 3105 Masison, Daniel C., 2458 Meyer-Leon, Leslie, 235 Munroe, David, 3441 Lowenstein, Daniel H., 1153 Massoglia, Sharon, 3048 Meyerowitz, Elliot, 5991 Munroe, Donald G., 3307 Lowndes, Noel F., 4990 Masson, Norma, 6192 Meyerson, Gabrielle, 361 Murakami, Takashi, 1180 Lowry, Charles V., 5921 Massone, Annalisa, 2731 Miassod, Raymond, 5455 Murialdo, Helios, 5894 Lowy, Douglas R., 3852 Mastrangelo, Molly F., 2882 Michaeli, J., 3535 Murray, Richard, 4953 Lu, John, 4728 Masurel, Remco, 2570 Michel, Denis, 3584 Muscarella, Donna E., 3386 Luche, Ralf M., 3884 Matera, A. Gregory, 5424, Middleton, Kim M., 727 Mushinski, J. Frederic, 2715 Lugo, T. G., 2660 5876 Miesfeld, Roger L., 4574 Myers, Richard M., 518, 972 Luk, Daniel, 5532 Mathews, C. K., 5688 Milbrandt, Jeffrey, 6454 Myler, P. J., 6436 Lum, Lynette S. Y., 6709 Mathieu, Colette, 430 Miles, David J., 6097 Mylin, Lawrence M., 4623 Luo, Kunxin, 5305 Mathy-Hartert, Marianne, Miller, A. Dusty, 464, 4239 Luoh, Shiuh-Wen, 681 4690 Miller, Brian R., 1873 Nabeshima, Yo-ichi, 2562 Lutzker, Stuart, 1672 Matrisian, Lynn M., 4284 Miller, Daniel G., 4239 Nabeshima, Yoko, 2562 Lyford, Kimberly A., 5244 Matsuda, Michiyuki, 830 Miller, Walter L., 6013 Nadal-Ginard, Bernardo, 2133 Lynch, M., 6084 Matsugi, Takayasu, 1259 Millette, Clarke F., 1828 Nadin-Davis, Susan A., 549 Matsui, Yasushi, 4116 Mineo, Ikuo, 5271 Naftilan, Allen J., 5536 Ma, Chi, 1338 Matsukage, Akio, 872 Mitchell, Aaron P., 2104, 6103 Nag, Dilip K., 4420 Ma, Junli, 5663 Matsumoto, Kunihiro, 4303 Mitchell, Mark T., 4826 Nagata, Shigekazu, 2002 Ma, Patrick C.-C., 3297 Matsushima, Hiroshi, 5015 Mitchell, Pamela J., 6003 Nakabayashi, Hidekazu, 1461 Maa, Ming-Chei, 1484 Matsushime, Hitoshi, 2261 Mitomo, Katsuyuki, 561 Nakafuku, Masato, 4303 Macchia, Giovanni, 2731 Matsuzawa, Yumiko, 3095 Mitts, Marijane R., 3873 Nakajima, Toshihiro, 2757 Mach, Bernard, 965 Mauxion, Fabienne, 5027 Miura, Kazunobu, 1461 Nakamura, Takafumi, 3700 MacLeod, Carol L., 3663 Maxson, Rob, 6730 Miyamoto, Shigeki, 1593 Nakanishi, Mikiye, 711 MacMurray, Armand, 138 Maxwell, Ian H., 474 Miyao, Yasuyoshi, 1461 Nakao, Kazuhiko, 1461 Madden, Stephen L., 5950 Mayeda, Carol, 5991 Miyauchi, Kumi, 577 Nakao, Mitsuyoshi, 3646 Madura, Kiran, 3256 May-Siroff, Mary, 5496 Mizel, Steven B., 3824 Nandi, Asit, 4324 Mager, Dixie, 1382 Mbonyi, Kaishusha, 4518 Mizoguchi, Akira, 2645 Nandi, Satyabrata, 1593 Mahadevan, Subramony, 4447 McAllister, William T., 4529 Moav, Boaz, 3432 Narayan, Prema, 4456 Maher, Stephen E., 5150 McBurney, Michael W., 4058, Mok, E., 5822 Nasim, Anwar, 549, 3750 Maher, Veronica M., 3945 6445 Molloy, Christopher J., 6069 Nath, Surend T., 4139 Maki, C. G., 4524 McCarthy, Philip L., Jr., 4396 Molloy, George R., 6533 Nathan, Asher T., 1714 Malavasic, Michael J., 2809 McCarthy, Thomas L., 4473 Monget, Philippe, 4690 Natori, Shunji, 6114 Maldonado, Edio, 6335 McClinton, Diana, 705 Monk, Marilyn, 4987 Nayak, Debi P., 4139 Maller, James L., 310, 1689 McConnell, D. G., 6654 Mons, B., 6759 Naylor, Susan L., 518 Maltby, Victor, 2521 McCormick, Frank, 2901, Montalvo, Ermelinda, 3397 Nazar, Ross N., 377 Malynn, Barbara A., 1799 5977 Montgomery, K. T., 2625 Needleman, Richard B., 3797 Manam, Sujata, 1545 McCormick, J. Justin, 3945 Mooney, Duane T., 2801 Neff, Norma, 898, 3397 Mancebo, Ricardo, 2492 McCraith, Stephen M., 1049 Moore, Chris C. D., 6013 Neigeborn, Lenore, 6103 Manfioletti, G., 2924 McCusker, John H., 2941 Moore, Peter D., 785, 794 Neitzel, Marianne D., 2669 Maniatis, Tom, 1329 McDonald, Vicki L., 1969 Moore, Terry L., 5747 Nelkin, Barry D., 1773 Manley, James L., 1244, 4334 McDonnell, Susan E., 4284 Morandini, Piero, 4080 Nellen, Wolfgang, 4080 Maples, Phillip B., 3591 McDonnell, Timothy J., 1901 Moreau, J., 5349 Nelms, Keats, 3843 Maquat, Lynne E., 5215 McEntee, Kevin, 3174, 5553 Morella, Karen K., 5967 Nelsen, Barbara, 3145 Mar, Janet H., 3468, 4271 McEwen, Joan E., 3027 Morello, D., 3185 Nelson, Camille E., 5772 Maran, Avudaiappan, 4424 McGowan, Clare H., 3847 Morgan, Garry T., 727 Nelson, Christopher A., 5027 Marathe, Sudhir, 2638 McHale, Megan M., 2678 Morgenstern, Jay P., 4961 Nesterov, Alexander, 5011 Marck, Christian, 2437 McKearn, John P., 1901 Mori, Masataka, 1180 Neubauer, Michael G., 1882, Marcu, Kenneth B., 382 McKenzie, Edward A., 6674 Morimoto, Richard I., 3125 1969 Mardon, Graeme, 681 McKiernan, Martin, 1931 Morisaki, J. Hiroshi, 6524 Neuman de Vegvar, Henry Margolis, B., 435 McKinley, Michael P., 1153 Morishita, Kazuhiro, 1259 E., 3365 Margolskee, Robert F., 1367 McMorris, F. Arthur, 5586 Moriuchi, Tetsuya, 872 Nevins, Joseph R., 5138 Marguet, Didier, 3551 McMullin, Thomas W., 4590 Morley, Kimberlin L., 4565, Newberry, Rodney D., 5027 Marinkovic, Sanja, 1573, 5967 McStay, Brian, 2793 5473 Newcomb, Elizabeth W., 405 Mariottini, Paolo, 430, 816 Meaden, Philip, 3013 Morris, Charles F., 1931 Newlon, Carol S., 3917 Marks, P. A., 3535 Means, Anna L., 653, 1390 Morris, David R., 5525 Newman, Anna P., 3405 Marks, Rory M., 5830 Meeker, Timothy C., 1680 Morrisey, Joanne, 6381 Ng, Davis T. W., 1989 Marquardt, Hans, 6244 Meerovitch, Karen, 1134 Morrison, Deborah K., 2359 Ni, Baofu, 3797 Marriott, Susan J., 4192 Meese, Eckart U., 4574 Morrison, Trudy, 449 Nichols, Warren W., 1545 Marshall, John, 5569 Meijer, Ingeborg, 5857 Morrow, Bernice E., 5226 Nicholson, Pamela R., 1743, Marshall-Carlson, Linda, Meisler, Miriam H., 2513 Morse, Herbert C., III, 3562 5927 1105, 4744 Mellstrom, Karin, 361, 801 Moses, Kevin, 539 Nickoloff, Jac A., 1174, 4837 Martial, Joseph A., 4690 Mdmet, Sylvie, 2049 Mosialos, George, 2840 Nielsen, David A., 371 Martin, Brian M., 4294 Mendelsohn, Laurel, 1199, Mosrin, Christine, 4737 Nikolsky, Nikolay, 5011 Martin, Christopher, 1270, 1209, 4990 Moss, Bernard, 5433 Nikovits, William, Jr., 3468 1908 Mendoza, Arthur E., 6051 Motte, Phillippe, 3216 Nimer, S., 6084 Martin, Debra J., 1950 Mensa-Wilmot, Kojo, 720 Mount, Stephen M., 2492 Nir, Uri, 146, 5021 Martin, G. Steven, 3020, 6244 Merrick, William C., 1134 Mowatt, Michael R., 3036 Nishida, Yasuyoshi, 872 Martfn-Parras, L., 3078 Mestril, Ruben, 3334 Mudd, Robert, 4770 Nishigaki, Takashi, 4334 Martinson, Harold G., 16 Metsis, Madis, 4701 Mudgett, John S., 37 Nishikura, Kazuko, 5586 VOL. 10, 1990 AUTHOR INDEX vii

Nishimoto, Takeharu, 577 Ozato, Keiko, 2041, 3700 Phi-Van, Loc, 2302 Ramirez, Manuel, 2820 Nishitani, Hideo, 577 Ozer, H. L., 5688 Phizicky, Eric M., 1049 Ramji, Dipak P., 2653 Nishiyori, Atsushi, 1180 Ozturk, Mehmet, 3216, 5772 Piaggio, Giulia, 387 Ransone, Lynn J., 4565 Nishizawa, Makoto, 3095 Piatigorsky, Joram, 3700, 6813 Rapp, U. R., 2503 Nishizawa, Mikio, 2002 Paalman, Mark H., 4816 Picci, L., 2423 Rapp, Ulf R., 3325, 3562, 3828 Nissen, Lynette, 4466 Pace, T., 2423, 6759 Pickett, Cecil B., 1841 Rashka, Kay E., 2669 Nissen, Mark S., 3067 Padmanabha, Ramesh, 4089 Picologlou, Susan, 1017 Rattray, Alison, 3492 Nitsch, Doris, 3334 Page, David C., 681 Pieler, Christian, 4473 Rauscher, Frank J., III, 4243 Noegel, Angelika A., 3727 Page, Dawne M., 3003 Pierani, Alessandra, 6204 Ravetch, Jeffrey V., 3243 Nolan, Garry P., 1697 Pahlman, Sven, 361 Pierce, Jacalyn H., 2749, Ray, Anuradha, 5736 Nomiyama, Hisayuki, 3646 Paietta, John V., 5207 3247, 3562, 4846 Ray, Peter N., 193 Nomura, Masayasu, 2049 Pallavicini, Maria G., 401 Pikaard, Craig S., 3810, 4816 Raychaudhuri, Gopa, 316 Nonaka, Masaru, 6283 Palmieri, Marta, 2554 Pilgrim, David B., 2801 Raychaudhuri, Pradip, 5138 Nonet, Michael, 1010, 1270 Pan, Bin-Tao, 923 Pinra, Benjamin, 625 Raymond, Martine, 1642, 6036 Nordan, Richard P., 2443 Pan, Julian, 243 Pine, Richard, 2448 Raymond, Victoria W., 2973 Nordeen, Steven K., 310 Pang, Qishen, 3505 Platt, Frances M., 1901 Razin, S. V., 5349 Nori, Mukund, 1254, 4155 Panganiban, Grace E. F., 2669 Platt, Terry, 2599 Read, Douglas, 4334 Norman, Barbara, 3700 Papas, Takis S., 1249 Plomp, Arianne, 5416 Reddy, Ram, 939 Northemann, Wolfgang, 3483 Papayannopoulou, Thalia, Plowman, Gregory D., 1969 Reed, John C., 4370 Novak, Thomas J., 6325 1382 Plumb, M., 3838 Reed, Randall R., 2237 Nunez, Gabriel, 1901 Pape, Louise K., 4816 Podgorski, Gregory J., 1921 Reed, Steven I., 510, 2966, Nusse, Roel, 4170 Papkoff, Jackie, 2723 Podos, Steven, 1270 3847, 4439 Nussmeier, Mariann, 6426 Parada, Luis F., 6755 Pohjanpelto, Pirkko, 5814 Reeder, Ronald H., 2793, Nye, Steven H., 5753, 5763 Pardee, Arthur B., 5591 Polakiewicz, Roberto D., 736 3810, 4816 Paris, J., 4123 Polakis, Paul, 5977 Reedijk, Michael, 5601 Obici, Silvana, 1033 Paris, Jeannie, 5634 Polisky, Barry, 1538 Reeves, Roger H., 4163 O'Brien, Melanie C., 2855 Park, Edwards A., 480, 6264 Pollard, Jeffrey W., 5187 Rego, Kim, 1199 O'Brien, Timothy P., 3569, Park, Eun-Chung, 2081, 4932 Pollard, K. Michael, 2164 Reich, Claudia, 5548 6769 Parker, Malcolm G., 5529, Pollock, Roberta, 1697 Reid, L. M., 2625 Occhiodoro, Filomena S., 6607 Pologe, Laura G., 3243 Reid, Susan, 6755 2950 Parker, Roy, 2269 Ponticelli, Alfred S., 2832 Reinberg, Danny, 6335 Ochs, Vincent, 1882 Parnaik, Veena K., 1287 Ponzi, M., 2423, 6759 Reinherz, Ellis L., 2407 Odijk, H., 5806 Parsons, Marilyn, 4545 Poon, David, 3770 Reith, Walter, 965 Odijk, Hanny, 2570 Pasco, David S., 6408 Poot, Raymond, 4678 Reitman, Marc, 2774 Offringa, Rienk, 5857 Pastan, Ira, 2443 Porter, Gregory, 2874 Remacha, Miguel, 2182 Ogawa, Nobuo, 2224 Paszkowski, Jerzy, 492 Portillo, Francisco, 4110 Remington, Mary P., 6097 Oh, Dahlkyun, 1415 Paterson, Andrew J., 4596 Porton, Barbara, 1076 Repetto, Barbara, 4221 Ohe, Yoshihide, 1461 Patinkin, Deborah, 6046 Potashkin, Judith A., 3524 Reshef, Lea, 2418 Ohmen, Jeffrey D., 3027 Patterson, James H., 4826 Potrykus, Ingo, 492 Reshetnikova, Galina, 5011 Ohta, Tsunetaka, 6491 Paul, David L., 1754 Poustka, Annemarie, 4016 Reyes, Antonio, 3314 Ohtsubo, Motoaki, 577 Paulson, K. Eric, 1841 Poyton, Robert O., 1297, 4984 Reynolds, Albert B., 837 Ohtsuka, Eiko, 1461 Pavan, William J., 4163 Pozzatti, Rudy, 413 Reynolds, Pamela J., 4266 Ohtsuka, Masahiro, 1664 Pawson, T., 2503 Prakash, Satya, 2485, 3256 Reynolds, Richard J., 4837 Okada, T. S., 958 Pawson, Tony, 2521, 5601 Prasad, Tottempudi K., 3979 Rhee, Sue Goo, 2359 Okamoto, Shuichi, 561 Peacock, James W., 3307 Pratt, M. A. Christine, 6445 Rhoads, D. D., 4524 Okamura, Sara, 1270, 1908 Pearson, Nancy J., 6097 Preer, John R., Jr., 1538 Rhoads, David B., 6491 Okuyama, Kazuhiko, 4987 Pecorino, Lauren T., 5883 Prendergast, George C., 1265 Rhodes, Simon J., 3934 Olson, Eric N., 1516 Peers, Bernard, 4690 Preston, Gregory M., 442 Richards, J., 6084 O'Mahony, D., 3105 Pell, Linda M., 2950 Preston, Robert A., 3737 Richardson, Jane, 6257 O'Malley, Bert W., 6607 Pellicer, A., 2983 Presutti, Carlo, 2437 Richardson, Paul, 2840 Omata-Yamada, Toshiko, Pellicer, Angel, 405, 1556 Pret, Anne-Marie, 1423 Richon, V. M., 3535 1822 Pelto-Huikko, Markku, 4701 Price, M., 3421 Richter, Joel D., 5609, 5634 Omilli, F., 4123 Penn, Linda J. Z., 4961 Principato, MaryAnn, 3562 Rickles, Richard J., 5883 Ordahl, Charles P., 3468, 4271 Perelman, Dalia, 3284 Prochownik, Edward V., 5333 Riehl, Robert, 273 Oren, Rachel, 4007 Peretz, Mary, 1382 Prockop, Susan, 1697 Rienhoff, Hugh Y., Jr., 3619, Oriahi, E., 3105 Perez-Stable, Carlos, 1116 Prokop, Carol A., 6290 6624 Orkin, Stuart H., 3675, 4854, Perkins, Lizabeth A., 3232 Protic, Miroslava, 2041 Rifkind, R. A., 3535 6051, 6596 Perona, Rosario, 4110 Prusiner, Stanley B., 1153 Riggs, Arthur D., 4987 Orlean, P., 4612 Perrimon, Norbert, 3232 Prystowsky, Michael B., 4846 Rijsewijk, Frans, 4170 Orlean, Peter, 5796 Perry, David J., 6408 Pyper, Joanna M., 2035 Riley, Timothy E. W., 6664 O'Rourke, Edward C., 2901 Perry, Michael, 1516 Quan, Franklin, 910 Rine, Jasper, 672, 5945 Ortiz, Daniel F., 2090 Persson, H&kan, 4701 Quilliam, Lawrence A., 2901 Rippe, R. A., 689 Osawa, Shoji, 2931 Perussia, Bice, 5586 Quinn, Patrick G., 3357, 4712 Ritzen, E. Martin, 4701 Osborn, Rebecca C., 1593 Pessara, Ulrich, 4146 Quinton, Tina J., 1891 Riva, Michel, 4737 Osborne, H. B., 4123 Petch, Leslie A., 2973 Rizzo, Maria-Giulia, 303 Oshima, Yasuji, 2224 Peterlin, B. Matija, 711 Racaniello, Vincent R., 5700 Roark, Margaret, 5991 Ostertag, Wolfram, 2302 Petersen-Bj0rn, Sara, 1217 Radcliffe, Gail, 382 Robberson, Barbara L., 84 Ostrowski, Michael C., 1 Petes, Thomas D., 4420 Radonovich, Michael F., 4192 Robbins, Keith C., 3806, 5496 Otaka, Eiko, 6544 Petrucco, S., 254 Raghavan, K. Vijay, 5991 Robbins, P. W., 4612 Ottavio, Luigi, 303, 3289 Philipson, L., 2924 Rajagopalan, Malini, 1940 Robbins, Stephen M., 918 Otte, Arie, 4170 Philipson, Lennart, 1525 Rajbhandary, Uttam L., 4486 Roberts, Anita B., 1492, 4978 Owen, Russell D., 1 Phillips, Paul D., 4846 Ramamurthy, Viraraghavan, Roberts, James, 1719 Owens, James D., 2715 Phillips, Robert A., 6586 1484 Roberts, Thomas M., 2909 viii AUTHOR INDEX MOL. CELL. BIOL.

Robertson, Elizabeth J., 1799 Sadler, Susan E., 1689 Seaton, Brent L., 3750 Silver, G., 6765 Robertson, Kent A., 2154 Sakai, Akira, 4130 Sebastian, Joseph, 4630 Silver, Julie C., 273 Robertus, Jon D., 6257 Sala-Trepat, Josd M., 991 Sefton, Bartholomew M., Simon, Ruth, 5609 Rochford, Rosemary, 4996 Salomon, David S., 4027 1853, 4266, 5305 Simons, Kai, 6578 Rodaway, Adam R. F., 5388 Sambrook, J. F., 4612 Segal, Anthony W., 5388 Simpson, Elizabeth M., 681 Rodrigues, Mabel, 3987 Samuelson, Linda C., 2513 Segatto, Oreste, 2749 Simpson, Robert T., 2247 Roebuck, Kenneth A., 341 Sancar, Gwendolyn B., 4630 Sehgal, Pravinkumar B., 5736 Simske, Jeffrey S., 6769 Roeder, G. Shirleen, 2379 Sanchez, Massimo, 1033 Seidman, Shlomo, 6046 Singer, Jeffrey D., 1174 Roeder, Robert G., 2145, Sanchez-Pozo, Antonio, 4356 Sekiguchi, Takeshi, 577 Singer, Richard A., 6356 5532, 6204 Sander, Chris, 6578 Sellers, Joan W., 5077 Singer-Sam, Judith, 4987 Roehl, Holger H., 3834 Sanders, Laura, 3569 Sellers, William, 1680 Singh, Harinder, 1406 Roesler, William J., 480, 6264 Santangelo, George M., 859 Semba, Kentaro, 3095 Singh, Kavita, 5510 Rogers, Kathleen T., 2111 Santoro, Bina, 2437 Semenza, Gregg L., 930 Singh, Ravinder, 939 Roghi, C., 4123 Santos, Cruz, 2182 Sen, Ganes C., 5055 Singh, Surinder P., 5279 Rohrschneider, Larry R., 2528 Santos, Eugenio, 3117 Sen, Ranjan, 3145, 5027 Sithanandam, G., 3325 Roman, Dragos G., 850 Sathe, Ganesh M., 2678 Sengstag, Christian, 672 Siu, Chi-Hung, 3297 Romaniuk, Paul J., 5166 Saunders, Michael J., 5721 Sengupta, Piali, 6809 Skalka, Anna Marie, 696 Rombola, Hector, 474 Sawada, Ikuhisa, 243 Sentenac, Andre, 2437, 4737 Skelly, P. J., 1530 Ron, David, 1023, 4389 Sawadogo, Michele, 3415 Seperack, Peter K., 501 Skog, Sven, 4701 Rooney, Robert J., 5138 Sawai, Shoji, 2017 Serrano, Ramon, 4110 Skoultchi, Arthur I., 4324 Rosbash, Michael, 6417 Sax, Christina M., 2349, 3700, Severinsson, Liv, 801 Skroch, Petra, 4778 Rose, Elise, 1642 6813 Sha, William C., 5027 Skurla, Robert M., Jr., 2715 Rose, John K., 1853 Saxe, Stephen A., 2367 Shackleford, Gregory M., 146 Slater, Emily P., 625 Rose, K., 3105 Scafe, Charles, 1010, 1270 Shago, Mary, 2335 Slipetz, Deborah, 3013 Rosen, Haim, 736 Scales, Jon B., 1516 Shai, Shaw-Yung, 4294 Sloan, Steven R., 405 Rosen, Ora M., 743 Scarpulla, Richard C., 5753, Shannon, M. Frances, 2950 Small, Gillian M., 1399 Rosenberg, Martin, 6152 5763 Shapiro, David J., 371 Smiley, B. L., 6436 Rosenberg, Naomi, 4365 Schaffhausen, Brian S., 2909 Sharp, Philip A., 1406, 4384, Smith, Alan E., 5569 Rosette, Caridad, 401 Schalasta, Gunnar, 5558 5562 Smith, Bruce F., 3268 Ross, S. R., 5822 Schappert, Keith T., 6123 Sharpe, Arlene, 1452 Smith, Clayton A., 6512 Rossant, Janet, 2335, 2521 Schekman, Randy, 672, 6024 Sharpe, N. G., 6817 Smith, Cynthia L., 615 Rossiter, Belinda J. F., 6805 Schenk, Paul, 4678 Shaul, Yosef, 3683, 4427 Smith, Harold E., 2104, 6103 Roth, Sharon Y., 2247 Scher, Charles D., 184 Shaulsky, Gad, 6565 Smith, Joseph, 3492 Rothblum, L. I., 3105 Scherrer, K., 5349 Shaw, Andrey S., 1853 Smith, Mark R., 3828 Rothblum, Larry, 3810 Schiestl, Robert H., 2485 Shawver, Laura K., 4155 Smith, Martin L., 6003 Rothenberg, Ellen V., 6325 Schieven, Gary L., 6244 Shay, Jerry W., 2027 Smith, Michael J., 5333 Rothman, Paul, 1672 Schildkraut, C. L., 3078, 4314 Shean, Mary Lou, 5007 Smith, S. D., 3105 Rotter, Varda, 6565 Schildkraut, Carl L., 4324 Sheer, Denise, 5365 Smith, S. David, 3810 Rottman, Fritz M., 4456 Schimke, R. T., 1584 Sheets, Michael D., 1705 Smits, Alida M., 5857 Roufa, D. J., 4524 Schimmel, Paul, 1476, 1633 Sheffery, Michael, 5958 Snow, Claudette M., 2513 Rougvie, Ann E., 6041 Schlessinger, J., 435, 4035 Shen, C.-K. James, 282 Soder, Olof, 4701 Rousseau, Guy G., 1811 Schlessinger, Joseph, 3048, Shenk, Thomas, 1244, 3343, Sogawa, Kazuhiro, 1470 Roussel, Martine F., 1664, 4770 6397 Sollner-Webb, Barbara, 615, 2407 Schlissel, Mark S., 5397 Shen-Ong, Grace L. C., 2715 4816, 4920, 4970 Rovera, Giovanni, 4846 Schmid, Carl W., 5424, 5876 Sherman, David R., 3036 Solomon, Frank, 5286, 5295 Roy, A., 5257 Schmidhauser, Thomas J., Sherr, Charles J., 1664, 2407, Sommer, Jurg M., 4545 Roy, K. L., 4379 5064 2703 Sommer, Steve S., 3013 Roy, Rabindra N., 154 Schmidt, Ann, 2176 Shibuya, Masabumi, 2261 Sonenberg, Nahum, 1134 Rozen, Florence, 1134 Schmidt, Emmett V., 4406 Shiels, Brian R., 3483 Sorce, Lilly M., 6586 Ruaro, M. E., 2924 Schmidt, Wilhelm, 4100 Shih, Andy, 1793 Soreq, Hermona, 6046 Ruden, Douglas M., 1432 Schmit, A., 4035 Shih, Cheng-Kon, 3397 Sorrentino, Vincenzo, 1525 Rudenko, Gloria, 3492 Schmitt, Jacky, 3456 Shim, Joseph, 3405 Spear, Brett T., 5047 Rudman, Bertina M., 1538 Schmitt, Manfred J., 4807 Shimada, Kazunori, 3646 Spear, David H., 2315 Ruiz, Joseph C., 3056 Schneider, C., 2924 Shimamoto, Takuya, 2757 Spector, David L., 3524 Ruoff, Berthie M., 3386 Schnieke, Angelika, 1452 Shimizu, Hiroko, 561 Sperle, Karen, 103, 113 Ruppert, J. Michael, 5408 Scholer, Hans R., 4100 Shimizu, Yuki, 4130 Spickofsky, Nancy, 1367 Ruscetti, Francis W., 4978 Schreck, Ralf, 1281 Shimotohno, Kunitada, 4401 Spiegelman, George B., 918 Rush, Mark G., 1793 Schrewe, Heinrich, 2738 Shin, Hee-Sup, 138 Sporn, Michael B., 1492, 4978 Rushmore, Tom, 1841 Schrier, Peter, 5416 Shirsat, Neelam, 4846 Spotts, Gerald D., 3952 Russell, David G., 4506 Schroetke, Robert M., 310 Shiue, Lily, 518 Spudich, James A., 3578 Russell, Paul, 3847 Schryver, Brian, 2723 Shively, John E., 2738 Sreenan, Catherine M., 3709 Russo, Vincenzo E. A., 5064 Schulte, Roberta, 4266 Shortle, David, 2308 Srivastava, Rakesh, 243 Ruth, Richard S., 1423 Schultz, Janet, 4744 Showalter, Stephen D., 3137 Srivastava, Shiv, 3117 Rutter, William J., 146, 464 Schuster, Tillman, 4905 Shoyab, Mohammed, 1969 Stacey, Dennis W., 6683 Ryan, Aimee K., 154 Schuster, Wolfgang, 2428 Shtivelman, E., 1835 Stack, Sean P., 6785 Ryan, Kenneth, 4816 Schutz, Gunther, 3334 Shulman, Marc J., 4466 Stadel, Jeffrey M., 2582 Rzeszowska-Wolny, J., 5349 Schuuring, Ed, 4170 Shuman, Jon, 6264 Stadnyk, A. W., 6436 Schvartzman, J. B., 3078 Shumard, Christine M., 3868 Stafford, Jeannine, 705 Saatcioglu, Fahri, 6408 Schwartz, David C., 615 Sibley, Carol H., 422 Stanley, Edouard, 4603 Sabina, Richard L., 5271 Schwartz, Robert J., 528 Siegall, Clay B., 2443 Stanton, Brian R., 6755 Sabol, Steven L., 3717 Schwarz, Lindsay A., 3087 Siegfried, Zahava, 6073 Stavnezer, Janet, 382, 397 Sachse, Astrid, 4080 Scott, Richard W., 4045 Sievert, Laura L., 4045 Steams, Tim, 223, 6690 Sadhale, Parag P., 2599 Searles, Lillie L., 1423 Sijts, Alice, 5416 Steele, Edward J., 5187 VOL. 10, 1990 AUTHOR INDEX ix

Stein, Bernd, 5857 Szeto, Daniel P., 341 Ting, Jenny Pan-Yun, 5747 Van Doren, Kevin, 1769 Stein, David A., 6785 Szostak, Jack W., 4932 Tipper, Donald J., 2582, 4807 Van Dyke, Michael W., 3415 Stein, Roland, 1564 Szyf, Moshe, 4396 Tisch, Roland, 5340 van Ham, Reinier C. A., 2570 Steinberg, Bettie M., 4424 Tjaden, Gabrielle, 3277 van Hoef, Angeline, 3792 Steiner, Bart, 1891 Takagaki, Yoshio, 1244 Tjoelker, Larry, 3224 Van Houten, J. Virginia, 3917 Stern, David F., 1164 Takagi, Nobuo, 2261 Todaro, George J., 1969 van Leeuwen, Aad, 5416 Sternberg, Nat, 103, 113 Takahashi, Hiroshi, 3216 Todo, Takeshi, 5991 VanLeeuwen, Donald, 4401 Sternglanz, Rolf, 353 Takahashi, Shuji, 4007 Toh-e, Akio, 4303 Van Ness, Brian, 3843 Stevens, Anne M., 3087 Takai, Yoshimi, 2645, 4116 Toledano, Michel B., 850 Van Ness, Brian G., 569, 1950 Stevens, Kimberly A., 4582 Takeda, Junji, 5027 Tondravi, M. Mehrdad, 6091 van Ooyen, Albert, 4170 Stevens, Tom H., 3737 Takiguchi, Masaki, 1180 Tonks, Nicholas K., 458 Varmus, H. E., 1000 Stevenson, Mary Ann, 1234 Talerico, Melissa, 6299 Tornow, Joanne, 859 Varmus, Harold E., 518, 1307 Stewart, A. Francis, 3334 Tam, Ming, 282 Torphy, Theodore J., 2678 Varmuza, Sue, 2335 Stewart, David A., 6097 Tam, See-Ying, 6619 Torres, Claribel, 3868 Vasa, Monika Z., 154 Stewart, Mark J., 5007 Tamanoi, Fuyuhiko, 4303 Tosu, Mariko, 5359 Vassalli, P., 1498 Stewart, Valerie, 1672, 2096 Tamaoki, Taiki, 1461 Tovey, Michael G., 854, 2554 Vassilev, Lyubomir, 4899 Stier, Larue E., 47 Tan, Eng M., 2164 Toyoshima, Kumao, 1789, Vassilev, Lyubomir T., 4685 Stiles, Charles D., 6781 Tan, John L., 3578 3095 Vauti, Franz, 4080 Stillman, David J., 1743, 5927 Tanabe, Osamu, 2757 Transy, Catherine, 2407 Veillette, Andre, 5197 Stinson, Leslie, 3232 Tanaka, Akio, 3280 Trasler, Jacquetta M., 1828 Veinot-Drebot, Lela M., 6356 Stirling, Colin, 672 Tanaka, Kazuma, 4303 Trason, Ann, 6055 Velcich, Anna, 6273 St.-Jacques, Benoit, 138 Tanaka, Kenji, 2214 Travali, Salvatore, 303, 3289 Venner, Thomas J., 5160 Stolow, David T., 5937 Tanigawa, Gary, 4396 Traystman, Monica D., 930 Vera, Juan C., 743 Stone, David E., 510, 1622, Tanooka, Hiroshi, 5359 Treger, Janet M., 3174 Verma, Inder M., 1609, 4565, 4439 Tao, Jianshi, 1373 Treitel, Michelle A., 5616 5473, 5626 Stone, Debra, 3770 Tapley, Peter, 2528 Troelstra, C., 5806 Versteeg, Rogier, 5416 Strathern, Jeffrey N., 2882 Tardiff, J., 2625 Tromvoukis. Yvonne, 4967 Vesque, Christine, 3456 Stratling, Wolf H., 2302 Targa, F. Recillas, 5349 Trotta, R., 2983 Vida, Thomas A., 4638 Strickland, Sidney, 5883 Tate, James E., 1023 Trotta, Robert J., 1556 Vijayasarathy, S., 3036 Strobel, Marjorie C., 501 Tate, Peri, 2335 Trotter, Joseph, 4266 Vijayraghavan, Usha, 324 Strobl, Jeannine S., 5378 Taverna, Daniela, 4027 Trowbridge, Ian S., 2606 Vilcek, Jan, 1982, 3818 Strommer, Judith N., 2090 Taylor, Dean P., 2678 Trudel, Pierre, 6613 Villa-Garcia, Manuel, 5914 Stromstedt, Per-Eric, 4712 Taylor, Ian C. A., 165, 176 Trumbly, Robert J., 6500 Villarreal, Luis P., 4996 Strub, Katharina, 777 Taylor, Linda, 5187 Trus, Michael, 2418 Villeponteau, Bryant, 16, 1126 Struhl, Kevin, 2832, 3859, Taylor, William D., 37 Tsai, Charles, 752 Vincent, Alice C., 5077 4256, 4447, 5077 Tchou-Wong, Kam-Meng, Tsai, Men-Hwei, 6683 Vingron, Martin, 6578 Stuart, K., 6436 4650 Tsai, Ming-Jer, 1784, 6607 Vinogradova, Nina, 5011 Studier, F. William, 353 Teahan, Carmel G., 5388 Tsai, Shin-Feng, 6596 Vogel, Jonathan, 413 Stumph, William E., 341 Teeter, Larry D., 5728 Tsai, Sophia Y., 6607 Vogelmeier, Claus, 47 Stunnenberg, Henk, 3456 Telford, John L., 2731 Tsang, Sue Y., 711 Vogelstein, Bert, 634, 5408, Stuve, Laura L., 972 Temin, Howard M., 68 Tsong, Tian Y., 1773 5772 Su, Li-Kuo, 2619 ten Dijke, Peter, 4473 Tucker, Philip W., 982, 3690 Vogt, Volker M., 3386 Su, Sophia S. Y., 6103 Ten Hagen, Kelly G., 6348 Tullius, Thomas D., 4778 von Kleist, Sabine, 2738 Subramani, Suresh, 3750 Teranishi, Yutaka, 4116 Turcotte, Bernard, 5002 von Kries, Jens P., 2302 Suen, Ting-Chung, 6306 Tereba, Allan, 823 Turner, Jennifer A., 146 von Lindern, Marieke, 4016 Sugino, Akio, 1358 Terleth, , 4678 Tushinski, Robert, 4846 Voz, Marianne L., 4690 Suh, Eun Ran, 2960 Teruya, Julie H., 2315 Tye, Bik-Kwoon, 5707 Suh, Martha, 4412 Testerman, Nile, 1254 Tyrrell, Rex M., 4967 Wada, Yoh, 2214 Sukhatme, Vikas P., 1931, Thatcher, Jack D., 6264 Tzagoloff, Alexander, 4221 Wagenaar, Els, 4170 4243 Thayer, M. J., 2660 Uchida, Sanae, 577 Wager, Ruth E., 5983 Sukumar, Saraswati, 1593 Theunissen, Henri, 4170 Uemura, Hiroshi, 6389 Wagner, Josephine, 3013 Sullenger, Bruce A., 6512 Thevelein, Johan M., 4518 Ueno, Takaki, 4495 Wagner, Richard W., 5586 Sullivan, Kevin F., 2164 Thiele, Dennis J., 426 Uetsuki, Taichi, 2562 Wahl, Geoffrey M., 3056 Sultzman, Lisa A., 6709 Thierry, Francoise, 4431 Ullrich, A., 435, 4035 Wahli, Walter, 3926 Sumrada, Roberta, 3884, 5087 Thireos, George, 4375 Ullrich, Axel, 3048, 5521, Wahls, Wayne P., 785, 794 Sun, lvon, 6460 Thissen, Julia A., 4545 5977 Wakabayashi-Ito, Noriko, Sunnerhagen, Per, 3750 Thomas, David Y., 217 Ungers, Grace E., 6512 1822 Suplick, Kathleen, 6381 Thomas, Michael J., 5378 Wakamatsu, Yoshio, 2017 Surosky, Richard T., 5707 Thompson, Craig, 1382 Vadas, Mathew A., 2950 Walker, Katherine, 377 Susek, Ronald E., 6362 Thompson, Craig B., 3224 Vaidya, Akhil B., 6381 Walker, M., 3838 Sutrave, Pramod, 3137 Thompson, E. Brad, 5580 Valentine, Marc, 823 Wall, Randolph, 422 Suzuki, Yoshiaki, 872 Thompson, John, 2738 Van Aelst, Linda, 4518 Wallace, Linda J., 785 Swain, Judith L., 3709 Thompson, L. H., 5806 Vancurova, Ivana, 6460 Wallenburg, John, 6613 Swanson, Michele S., 4935 Thompson, Larry H., 6160 van Dam, Hans, 5857 Wallrath, Lori L., 5114 Sweet, Laurel J., 2413, 2787 Thomson, T., 2983 van de Putte, Pieter, 4678 Walsh, Martin J., 4356 Sweigert, Susan E., 5849 Thomson, Timothy M., 1556 van der Eb, Alex J., 2570, Walter, Peter, 777 Swendeman, Steven L., 5958 Thorner, Jeremy, 6244 5857, 6132 Wamsley, Penny, 4565 Swerdlow, Paul S., 4905 Thummel, Carl S., 6059 van der Geer, Peter, 2606, Wands, Jack, 3216 Swergold, Gary D., 6718 Thuriaux, Pierre, 4737 2991 Wang, Chiayeng, 6781 Swick, Andrew G., 6632 Tilghman, Shirley M., 28, Van der Hoorn, Frans A., 310 Wang, Ching C., 3659, 4545 Sykes, Kathryn, 95 5047 van der Minne, Carolien, 5416 Wang, Huaming, 1743, 5927 Szab6, Piroska, 2432 Timberlake. William E., 1815, Van der Ploeg, Lex H. T., Wang, Lu-Hai, 4068 Szeberenyi, J6zsef, 5314, 5324 4912 3492, 4506, 6079 Wang, S.-Y., 6654 x AUTHOR INDEX MOL. CELL. BIOL.

Wang, Sy-Shi, 4415 Widen, Steven G., 3852 Wright, Richard M., 1297 Youssoufian, Hagop, 3675 Waring, Richard B., 2960 Wiebauer, Karin, 2513 Wu, Barbara J., 6709 Yoza, Barbara K., 2145 Warner, Jonathan R., 5226, Wiest, Debra K., 5782 Wu, Carl, 752 Yu, Chun-Li, 6683 5235 Wigler, Michael, 2539 Wu, Hong, 1452 Yu, Chun-Yuan, 282 Wasilenko, William J., 1254 Wigley, Peter L., 1705 Wu, Huey-Nan, 5575 Yu, Guo-Liang, 2070 Watanabe, Tomoo, 561 Wilde, Margaret D., 6181 Wu, Jing, 1209, 4990 Yu, Hong, 3277 Weaver, Daniel C., 6791 Wilkinson, Miles F., 3663 Wu, Yvonne Y., 57 Yu-Lee, Li-Yuan, 3087 Weaver, David T., 5397 Willard, Huntington F., 6348, Wuerffel, Robert A., 1714 Yutzey, Katherine E., 3934 Weber, Michael J., 837, 1254, 6374 Wurm, Florian M., 401 1301, 3626, 4155 Willett, Catherine E., 4872 Wyllie, Fiona S., 5365 Webster, Keith A., 2402 Williams, D. G., 6817 Wynford-Thomas, David, 5365 Weeda, Geert, 2570 Williams, E. Dillwyn, 5365 Zagorski, John, 1145 Weeks, Gerald, 918 Williams, Frederick E., 6500 Xaio, Peter, 4974 Weih, Falk, 3334 Williams, Gregg T., 3125 Xiao, Hua, 3272 Zakian, Virginia A., 4415 Weil, D., 5865 Williams, Lewis T., 2359, Xu, Haixin, 2687 Zakut, Haim, 6046 Weil, P. Anthony, 1564, 2390 4728 Xu, Hua, 2695 Zaller, Dennis M., 1076 Weiner, Alan M., 5876 Williams, R. Sanders, 5671 Xu, Yan, 1217 Zannis, Vassilis I., 2653 Weinert, Ted A., 6554 Willis, Rebecca L., 6091 Xuan, Jian-Wu, 4795 Zaret, Kenneth S., 4582 Weinstein, Brant, 5286, 5295 Wilson, Cheryl, 449 Yagle, Kevin, 5553 Zarkower, David, 846 Weinstein, I. Bernard, 4650 Wilson, David B., 4854 Yamada, Hisafumi, 1822 Zarkower, David A., 1705 Weinstock, Keith G., 2882 Wilson, Deborah R., 6181 Yamagishi, Masahiro, 2049 Zehner, Zendra E., 2349 Weis, Lisa, 6335 Wilson, Samuel H., 3852 Yamaguchi, Masamitsu, 872 Zeller, Rolf, 4406 Weissman, Sherman M., 243 Wilusz, Jeffrey, 1244, 6397 Yamamoto, Ken-ichi, 561 Zeng, Wenlin, 2765 Wek, Ronald C., 2820 Winkler, Matthew M., 3994 Yamamoto, Tadashi, 1789, Zerial, Marino, 6578 Wellauer, P. K., 254 Winston, Fred, 4935 4027 Zhang, Ji, 5177 Wells, Gerald B., 2176 Wisdom, Gregory S., 3036 Yamanashi, Yuji, 3095 Zhang, Kang, 3232 Welsh, Phil, 6257 Wisdom, Ron, 5626 Yamashiro, Carl T., 3737 Zhang, Ke, 2901 West, Robert W., Jr., 5663 Wise, Jo Ann, 2874, 5548 Yanagida, Atsushi, 1470 Zhang, Yihong, 3818 Westaway, David, 1153 Wissinger, Bernd, 2428 Yancopoulos, George D., 1697 Zhao, Allan Zijian, 6730 Westerveld, A., 5806 Witte, Michael M., 5128 Yang, George P., 3569 Zhong, Xiao-hui, 770 Westerveld, Andries, 2570 Wittekind, Michael, 2049 Yang-Yen, H.-F., 3105 Zhou, Youwen, 4529 Westphal, Heiner, 3700 Wobbe, C. Richard, 3859 Yaniv, Moshe, 4431 Wevrick, Rachel, 6374 Wojcik, B. E., 5688 Yanofsky, Charles, 5064 Zhu, Li, 3906 Whelan, James, 1564 Wolczyk, David F., 3737 Yarden, Yosef, 6064 Zieve, Gary W., 4480 White, Bruce A., 442 Wold, Barbara J., 5646 Yasumoto, Ken-ichi, 1470 Ziff, Edward B., 1982, 6073, White, Eileen, 120 Wold, William S. M., 5521 Yeh, Elaine, 5721 6273 White, Marga B., 3690 Wolfe, John H., 3268 Yen, Muh-Yong, 4990 Zilberstein, A., 435 White, Martyn K., 1301 Won, Kwang-Ai, 3965 Yen, Tim J., 615 Zilberstein, Asher, 4770 White, Roger, 5529 Wong, William M., 377 Yoo, Christopher, 5586 Zimarino, Vincenzo, 752 Whitelaw, Emma, 6596 Woon, Chee Wai, 2931 Yoshimoto, Kenneth K., 4996 Zimmerman, Kathryn, 2096 Whiteway, Malcolm, 217 Word, Charlotte J., 3690 You, Kwang H., 1940 Zimmermann, Wolfgang, 2738 Whitlock, James P., Jr., 5098 Worton, Ronald G., 193 You, Qimin, 5166 Zinn, Steven A., 3717 Whitmer, Mary E., 1705 Woychik, Nancy, 1915 Young, Dallan, 2539 Zirngibl, Ralph, 2335 Whitney, J. Andrew, 1853 Wrabetz, Lawrence, 5586 Young, Elton T., 2801 Zitomer, Richard S., 5921 Whittemore, Lisa-Anne, 1329 Wright, David A., 1484, 4555 Young, Regina M., 6051 Zoller, Mark J., 1066 Wickens, Marvin, 295, 846, Wright, Kathryn A., 4389 Young, Richard A., 1010, Zon, Leonard I., 3675 1705 Wright, Kathy A., 1023 1270, 1908, 1915 Zong, Jian, 5580 SUBJECT INDEX VOLUME 10

3' splice site specificity ABF1 factor Activating transcription factor 47 3' exon, 2960 L2 ribosomal genes, 2437 CREB correspondence, 6192 group I intron, 2960 S. cerevisiae, 2437 Acute nonlymphocytic leukemia internal guide sequence, 2960 ABFI protein t(6;9), 4016 rRNA intron S. cerevisiae ADE3 self-splicing, 2960 ENOI and EN02 enolase genes, 4872 S. cerevisiae C,-tetrahydrofolate syn- T. thermophila, 2960 RAPI, repressor activator protein, thase mutants 3-Phosphoglycerate kinase 4872 noncatalytic function, 5679 glycosomes, 4545 transcription repression or activation, Adenosine deaminase gene import into T. brucei glycosomes 4872 human in vitro assay, 4545 v-abl exon 1, 4555 T. brucei, 4545 replacement in lymphoid transformation transcriptional arrest sites, 4555 3T3-TNR9 cells bcrlabl, 4365 mouse, 1484 protein kinase C myc, 4365 transcriptional arrest in exon 1, 1484 down regulation, 2122 ras, 4365 Adenovirus 3'-Terminal exons src, 4365 E1A UV cross-linking of polypeptides, 5937 Acetate utilization AP-1 transcription factor family, 5857 4A duplication-induced of a new degradation sequence, 5609 RNA helicase activity, 1134 gene, 2638 Jun/Fos, 5857 4F N. crassa, 2638 E I A-binding domain Achlya ambisexualis retinoblastoma susceptibility gene RNA helicase activity, 1134 85-kilodalton , 273 product, 3761 5' matrix attachment region heat shock protein, 273 simian virus 40, 3761 chicken hsp85, 273 early region IA lysozyme, 2302 steroid hormone cellular proliferation, maintenance of, 5' Splice receptor complex, 273 6664 preceding intron splicing, effect on, 6299 regulation, 273 conserved region 1, 6664 SS RNA genes a,-Acid glycoprotein gene immortalized fibroblasts, 6664 X. laevis cytokine response element, 3965 simian virus 40 large T antigen, 6664 promoter elements, intragenic, 5166 rat, 3965 membrane-associated protein TFIIIA-binding site, 5166 Acid phosphatase epidermal growth factor receptor 5S rRNA chromatin S. cerevisiae down regulation, 5521 S. cerevisiae, 2390 negative regulators, 5950 retrovirus-mediated gene transfer, 12-O-tetradecanoylphorbol- 13-acetate transcriptional regulation, 5950 5521 P450scc gene repression, 6013 Acidic ribosomal N-myc regulation 18S rRNA S. pombe, 2341 posttranscriptional control, 6700 disruption of production, 1145 ACOI vector, 6700 S. cerevisiae, 1145 molecular cloning, 3551 Adenovirus Ela snR128, 1145 S. cerevisiae mitochondria, 3551 creatine kinase expression synergistic regulation by glucose and brain, 1476 U 14 small nuclear RNA, 1145 glutamate, 3551 induction, 1476 9E3 mRNA Aconitase gene induction of a cellular enzyme for chicken embryo fibroblasts, 3813 ACOI, 3551 energy metabolism, 1476 mitogenicity, 3813 molecular cloning, 3551 transforming domains, 1476 morphological alteration, 3813 S. cerevisiae mitochondria, 3551 Adenovirus EI B phosphorylation, 3813 synergistic regulation by glucose and intermediate filaments, 120 9q34 glutamate, 3551 proteins, 120 aberrant transcription Actin transformation, 120 t(6;9), 4016 SC Adenovirus type 5 64-Kilodalton protein proximal promoter, 206 progression cross-linking, 1244 D. melanogaster, 206 suppression, 2027 polyadenylation substrates, 1244 mutations, temperature-sensitive, rat embryo, 2027 70-Kilodalton heat shock protein family suppression, 2308 Adenylate cyclase calmodulin-binding domain, 1234 regulatory elements, 206 S. cerevisiae, 3873 S. cerevisiae, 2308 Adenylyl cyclase A-431 cells SAC7 attenuator function, 2931 epidermal growth factor-receptor com- null alleles, 2308 RAS-responsive domains, 2539 plexes Actin SC gene S. cerevisiae, 2539 functional state, 5011 D. melanogaster stimulation distal promoter, 6172 2931 internalization, 5011 regulatory elements, positive and neg- G, protein a subunit mutation, A23187 ative, 6172 ADH III P450scc gene repression, 6013 a-Actin import, 2801 Aa2 chromosome cis-acting promoter elements, 528 processing, 2801 d20J, 501 P-Actin gene ADHI gene dilute locus deletion mutations, 501 Cyprinus carpio, 3432 GCRI product, 859 mouse, 501 regulation, 3432 S. cerevisiae, 859 Abelson murine leukemia virus Activating transcription factor 43 TUF/GRF/RAP binding sites, 859 immunoglobulin kappa alleles CREB Adh gene promoters recombination, 569 complex formation, related polypep- D. melanogaster, 539 pre-B cells, 569 tides, 6192 D. orena, 539 xi xii SUBJECT INDEX MOL. CELL. BIOL.

Adh transcription olfactory epithelium, 2237 hypoxic consensus operator, 5921 D. melanogaster, 3512 Alpha retinoic acid receptor gene Angiotensin II Drosophila cell lines, 3512 dominant negative mutation, 6445 c-jun induction, 5536 enhancer and silencer elements, 3512 embryonal carcinoma cell protein-tyrosine phosphorylation Adipogenic differentiation retinoic acid nonresponsive, 6445 calcium dependence, 6290 colony-stimulating factor gene expres- Alpha satellite DNA Angiotensin-converting enzyme sion, 4948 partial deletion mouse testis, 4294 ADP ribosylation factor centromere protein CENP-B, 6374 transcription initiation, 4294 S. cerevisiae chromosome rearrangement, mitoti- Angiotensinogen encoded by two genes, 6690 stable, 6374 transcription essential protein, 6690 chromosome, human, 6374 glucocorticoids, role of, 4389 African green monkey kidney cells aA-CRYBPI site interleukin-I stimulation, 4389 radiation-enhanced recombination, 37 mouse Angiotensinogen gene AGP/EBP thymidine kinase promoter, species- acute-phase response element transcription factor specific lens activation, 6813 binding of two proteins, 1023 C/EBP family member, 6642 a-Fetoprotein gene Anopheles gambiae al-I albumin gene, 1461 retrotransposable element, 863 N. crassa carotenoid biosynthetic gene human hepatoma cells, 1461 Antibody-induced mitogenicity cloning, 5064 c-Ha-ras CD2-c-fms receptor, 2407 photoregulation, 5064 down regulation, 1461 Antigen receptor sequence, 5064 regulatory elements, 5047 B lymphoma cells, 3003 Albumin enhancer transcriptional activation cell cycle arrest, 3003 mouse, 3896 heterokaryons, transient, 5047 G1 phase restriction point, 3003 negative regulatory element a-Fetoprotein gene promoter Antihormones novel DNA-binding protein, interac- repression a-fetoprotein gene promoter repression, tion with, 3896 antihormones, 5002 5002 Albumin gene chimeric receptors, 5002 chimeric receptors, 5002 x-fetoprotein gene, 1461 hormones, 5002 progesterone, 5002 binding of a liver-specific factor, 991 progesterone, 5002 Antisense-fos RNA extracellular matrix proteins, 1239 a-Globin gene c-Ha-ras-transformed cells hepatocytes, 1239 matrix attachment sites partial reversion of , 1545 human, 991 erythroblasts, avian, 5349 AP-1 human hepatoma cells, 1461 erythrocytes, avian, 5349 fos, site homology, 6273 c-Ha-ras structural, 5349 AP-1 complex down regulation, 1461 transcription related, 5349 transforming growth factor , 1 transcription Alpha-tropomyosin autoinduction, 1492 induction, 1239 alternative promoters, 1729 transforming growth factor PI1 promoter Albumin genes, independent activation alternative RNA processing, 1729 v-src gene products, 4978 Xenopus oocytes brain tropomyosin isoforms, 1729 transcriptional regulation, 4978 estrogen receptor, pure, 6674 rat, 1729 AP-I transcription factor family vitellogenin genes, chromosomal, 6674 Alu domain adenovirus EIA gene, 5857 Alcohol dehydrogenase gene assembly, 777 Jun/Fos, 5857 human binding to RNA, 777 Aplysia californica C/EBP molecules, 5007 dimerization of protein components, 777 protein kinase, cyclic AMP dependent hepatoma cells, 5007 signal recognition particle, 777 catalytic subunit, relative of, 6775 TATA box, 5007 Alu subfamily spermatozoa, 6775 trans activation, 5007 human, transpositionally and transcrip- apoB Alcohol dehydrogenase presequences tionally competent, 5424 human, 2653 ADH III, 2801 a-Amanitin promoter elements, 2653 mitochondrial import and processing, transcription unit, resistant to transcription, 2653 2801 procyclic acidic repetitive protein Apoiso-l-cytochrome c al-Antitrypsin deficiency genes, 3492 S. cerevisiae al-antitrypsin Mmineral springs allele, 47 T. brucei, 3492 mitochondrial targeting, 5763 human, 47 amdR gene structural domains, functionally inde- a1-Antitrypsin gene A. nidulans, 3194 pendent, 5763 highly conserved upstream regions, 760 analysis Apoiso-l-cytochrome c fusion proteins liver-specific expression, 760 functional, 3194 S. cerevisiae mouse, 760 sequence, 3194 mitochondrial targeting, 5753 aol-Antitrypsin Mn,ner, springs allele Amino acid analogs Apolipoprotein(a) gene al-antitrypsin deficiency, 47 resistance, 2941 human emphysema, 47 S. cerevisiae, 2941 DNA-binding protein, methylated, human, 47 AMPDI 4957 al-Inhibitor III gene splicing pathway, alternative DNA-binding protein, sequence spe- rat hepatic transcription 5' splice donor site, alternative, 5271 cific, 4957 cis-acting regulatory elements, 3483 RNA intermediate, 5271 highly repeated sites, 4957 a2 repressor Amphiregulin gene ARG1 mRNA nucleosomes, 2247 human, 1969 S. cerevisiae, 1226 S. cerevisiae, 2247 Amylase transcription and stability TRP1/ARS1 chromatin, 2247 gene complex evolution, 2513 kinetic data, 1226 a Platelet-derived growth factor receptor human, 2513 ARG3 mRNA characterization, 2237 ANBI gene S. cerevisiae, 1226 isolation, 2237 S. cerevisiae transcription and stability rat constitutive activation region, 5921 kinetic data, 1226 VOL. 10, 1990 SUBJECT INDEX xiii

Arginase (CARI) gene B cell 1B Tropomysin gene S. cerevisiae differentiation cis-regulating elements, 5036 cis-acting elements, positive and nega- dexamethasone, 4211 splicing, 5036 tive, 5087 lipopolysaccharide, 4211 Bone marrow cells induced expression, 5087 B cells mature B cells and macrophages, 3562 ARS Bcl-2-immunoglobulin transgene mouse, 3562 core consensus sequence deregulation, 1901 v-raf-v-myc, 3562 mutational analysis, 3917 immunoglobulin M and D-expressing, transformation, 3562 S. cerevisiae, 3917 1901 BOSI ARS binding factor I kappa immunoglobulin interacting genes required for transport autonomously replicating sequence germ line transcripts, 1950 endoplasmic reticulum, 3405 binding macrophages, 3562 Golgi complex, 3405 telomeric and nontelomeric, 810 mature, clonally related, 3562 S. cerevisiae, 3405 S. cerevisiae, 810 mouse, 1901, 1950 Bovine papillomavirus type 1 ARS elements transformation of murine bone marrow E2 D. melanogaster cells with v-raf-v-myc, 3562 transcription activation, 4431 S. cerevisiae, 5455 B lymphoma cells Bovine papillomavirus type 1 DNA scaffold-attached regions, 5442, 5455 antigen receptor, 3003 mouse, 3078 , budding and fission, 5442 cell cycle arrest, 3003 replication, 3078 ARS mutation G, phase restriction point, 3003 B-protein domain replication origin function, 265 Bacteriophage T7 platelet-derived growth factor, 54% reversion, 265 RNA polymerase v-sis, 54% S. cerevisiae, 265 S. cerevisiae nucleus, 353 briA ARS-binding protein signal-mediated import, 353 A. nidulans, 1815 S. cerevisiae, 887 target gene transcription, 353 zinc fingers, 1815 transcription activation Baculovirus 8-Bromo-cyclic AMP synergistic, 887 integration, 3067 inositol 1,4,5-triphosphate, 57 Arterioles T. ni, 3067 MDCK cells, 57 elastases, 45% TED, 3067 byri transforming growth factor a processing, BALB 3T3 cells mating-type genes 45% transformation starvation-induced transcription, 549 Aryl hydrocarbon response element mucAB, 5359 rasl, 549 cytochrome P450IAI gene plasmid misrepair gene, enterobacte- S. pombe, 549 DNA-binding factors, 6408 rial, 5359 Aspergillus nidulans BALB/c 3T3 cells C,-tetrahydrofolate synthase amdR gene growth factor-inducible protein, 6769 S. cerevisiae mutants analysis, 3194 Pip92, 6769 ADE3 gene product, noncatalytic briA, 1815 Basic fibroblast growth factor function, 5679 developmental regulatory gene c-fos induction, 1556 folate-dependent enzyme, 5679 repression, 4912 nerve growth factor, 1556 C3 gene upstream elements, 4912 NIH 3T3 fibroblasts human phosphatidylinositol hydrolysis, 6069 58-base-pair region, 6181 initiator (Inr)-like elements, 4912 phospholipase C-y overexpression, synergistic inducibility by interleukin-l zinc fingers, 1815 6069 and -6, 6181 ATF transcription factor platelet-derived growth factor, 6069 C6 zinc finger EIA PC12 cell line, 1556 LAC9 protein of K. lactis E4F, 5138 N-ras, 1556 DNA-binding specificity and affinity, ATF/CREB-like repressor, 5077 BCL2 5128 Autonomously replicating sequence malignant transformation of rat embryo PPR1 protein of S. cerevisiae ARS binding factor I, 810 fibroblasts, 4370 DNA-binding specificity and affinity, binding Bcl-2-immunoglobulin transgene 5128 telomeric and nontelomeric, 810 B-cell population C/EBP S. cerevisiae, 810 immunoglobulin M and D-expressing, hepatitis B virus enhancer, 4427 Autonomously replicating sequence 1901 rat liver, 4427 mutation deregulation, 1901 C/EBP family replication origin function, 265 mouse, 1901 AGP/EBP transcription factor, 6642 reversion, 265 bcrlabl C/EBP-binding sequences S. cerevisiae, 265 v-abl replacement serum amyloid A3 gene, mouse Autophosphorylation lymphoid transformation, 4365 cell-specific expression, 6624 epidermal growth factor, 4035 BET] Caenorhabditis elegans p561ck activation, 5197 interacting genes required for transport collagen, 2081 p56lck site, 5305 endoplasmic reticulum, 3405 mRNA Avian very-low-density apolipoprotein Golgi complex, 3405 trans-splicing, 1764, 1769 gene S. cerevisiae, 3405 trimethylguanosine cap, 1764, 1769 liver-specific factor Beta interferon 0. volvulus developmental changes, 154 enhanson domains, synergism between, transcribed regions, 2765 A/WSN/33 influenza virus 3987 rol-6, 2081 polymerase basic protein 1 gene regulation, 1329 spliced leader sequence, 2765 nuclear localization, 4139 human, 854, 3987 sqt-J, 2081 postinduction turnoff of expression, 1329 Calcitonin gene B2 transcripts, 4058 priming, 854 regulatory DNA sequences murine embryonal carcinoma cells, 4058 promoter activity, 854 differential utilization, 1773 xiv SUBJECT INDEX MOL. CELL. BIOL.

medullary thyroid carcinoma, 1773 2966 topoisomerase 1I sites, 2774 small-cell lung carcinoma, 1773 S. cerevisiae, 2966 glycoprotein tyrosine phosphorylation, Calcium regulation CDC39 837 prolactin gene, 442 CDC36, 2966 heat shock (stress) protein, small rat, 442 mating pheromone response pathway, induction, 4886 CAR] (arginase) gene 2966 posttranscriptional regulation, multi- cis-acting element, 3884 S. cerevisiae, 2966 level, 4886 repressor protein binding site, 3884 CDC42 insulinlike growth factor I receptor S. cerevisiae, 3884 S. cerevisiae phosphorylation, 3626 cis-acting elements, positive and nega- G25K cDNA, 5977 L23, 2562 tive, 5087 human homolog, 5977 lysozyme, 2302 induced expression, 5087 cDNA N-mnyc gene Carcinoembryonic antigen gene cysteine-rich cell surface protein expression, 2017 cloning, 2738 characterization, 4506 organization, 2017 Carcinogen T. brucei flagellar pocket, 4506 myosin light-chain gene Chinese hamster cells, 75 genome-free retroviruses, 1891 regulation, 2562 DNA amplification, 75 integrated, 1891 phosphatidylinositol kinase type I Carcinoma cDNA gene formation activity, 3280 calcitonin gene regulatory DNA pseudogenes, 68 pp6 c-src sequences retroviral vector particle infection, 68 human, 3280 differential utilization, 1773 Cell cycle mutant forms, 3280 embryonal cells DBF2 ppgorsk 2413 Moloney murine leukemia virus periodic expression in cell cycle, 1358 ribosomal protein S6 kinase expression, 4045 product homologous with protein mitogen-responsive, 2413 medullary thyroid, 1773 kinases, 1358 Rous sarcoma virus transformation, 837 small-cell lung, 1773 S. cerevisiae, 1358 S6 phosphorylation, 2787 Cardiac myocyte hyperplasia osteosarcomas skeletal muscle c-myc, 3709 p53 function, 5772 non-tyrosine protein kinase product, transgenic mice, 3709 Cell cycle arrest 4068 CArG elements antigen receptor, 3003 c-src gene product, 4068 Fos B lymphoma cells, 3003 c-ski proteins C terminus, 4243 DNA damage characterization, 3137 repression, 4243 S. cerevisiae RAD9, 6554 Ul enhancer transcriptional activation, 4243 G, phase restriction point, 3003 octamer and SPH motifs, 341 Carotenoid biosynthetic gene Cell division U I RNA gene expression, 341 al-I human placenta protein, 458 Xenopus S6 kinase II, 2413 cloning, 5064 tyrosine phosphatase microinjection, 458 Chicken embryo fibroblast cells photoregulation, 5064 Xenopus oocytes, 458 avian retroviruses, 3095 sequence, 5064 Cell surface protein efn gene N. crassa al-I, 5064 cysteine-rich human, 3095 Cartilage matrix protein gene T. brucei flagellar pocket, 4506 transformation, 3095 regulatory elements, 2432 Centromere Chimeric protein P-Casein gene human 1L6-PE40 epidermal growth factor activation, 4027 replication timing of associated DNA cell-specific toxicity, 2443 c-ERBB-2 activation, 4027 sequences, 6348 tumor cells, 2443 lactogenic hormone induction, 4027 protein CENP-B Chimeric tRNA-driven antisense tran- murine mammary epithelial cells, 4027 alpha satellite DNA, partial deletion, scripts Casein kinase II 6374 Moloney murine leukemia virus resis- S. cerevisiae, 4089 chromosome rearrangement, mitoti- tance, 6512 CCAAT/enhancer-binding protein cally stable, 6374 NIH 3T3 cells, 6512 phosphoenolpyruvate carboxykinase S. pombe, 1863 Chinese hamster cell line gene transcriptional regulation, 6264 S. cerevisiae B4-2-1 CCAAT-box-binding factor chromatin structure, 5721 complementation by S. cerevisiae hsp70 promoter nucleosome depletion, 5721 DPMI, 4612 human, 6709 Chicken dihydrofolate reductase amplicons, 1338 human 5' matrix attachment region, 2302 methotrexate-resistant, 1338 hsp70 promoter, stimulation of tran- 9E3 mRNA expression replication origins, 1338 scription from, 6709 mitogenicity, 3813 Chinese hamster cells CD2-c-fms receptor morphological alteration, 3813 carcinogen-induced DNA amplification, antibody-induced mitogenicity, 2407 phosphorylation, 3813 75 CD4 cells transformed by src, 3626 simian virus 40 CD8, 1853 chromatin origin region overreplication, 75 CD8 cross-linking, 5305 methylated, DNase I-resistant, 16 simian virus 40 replication, 4345 p56lck 1853 cooperativity between U1 gene enhancer Chinese hamster ovary cells p56lck phosphorylation, 5305 motifs, 341 DNA replication origin CD8 embryo, 2562 single-copy locus, 4685 CD4, 1853 embryo fibroblast cells, 3280 hsp70, 5160 CD4 cross-linking, 5305 embryo fibroblasts, 837, 2413, 2787, 3813 major heat shock protein family mem- p56lck 1853 human glucose transporter, 1301 ber, 5160 p561ck phosphorylation, 5305 src regulation, 1301 microtubule inhibitor-resistant mutants, CDC36 P-globin gene, 16 5160 CDC39, 2966 P-globin locus protein synthesis-dependent mRNA in- mating pheromone response pathway, DNase I-hypersensitive sites, 2774 crease VOL. 10, 1990 SUBJECT INDEX xv

c-jun, 5814 Chromosome 8 kinase insert, 5601 c-myc, 5814 murine T cells, 3663 macrophage lineage switching, 2703 ornithine decarboxylase, 5814 novel gene mouse, 2703 ribonucleotide reductase activity, ther- ecotropic retroviral receptor, closely phosphatidylinositol kinase, 5601 molabile, 5688 related to, 3663 phosphorylation, ligand-induced temperature-sensitive DNA mutant, 5688 isolation, 3663 intermolecular reaction, 1664 [3H]thymidine labeling protocols Chromosome ends receptor down modulation, 1664 cell cycle progression, 1584 human, 518 pre-B lymphoid cells expressingfms DNA replication, 1584 structure and variability, 518 genes, 2703 Cholinesterase gene expression Chromosome instability mutants Colony-stimulating factor genes manipulation microtubule function, 223 expression megakaryocytopoiesis, modulation of, S. cerevisiae, 223 myogenic and adipogenic differentia- 6046 Chromosome organization tion, 4948 Chromatid exchange T. brucei, 6079 Connexin43 gap junction protein XRCCJ, 6160 Chronic granulomatous disease, autosomal mouse fibroblasts, 1754 Chromatin 47-kilodalton protein phosphorylation, 1754 chicken, 16 retinoic acid, 5388 vole fibroblasts ,3-globin gene tissue-specific expression, 5388 uninfected and RSV-transformed, 1754 transcription, 16 transcriptional control by retinoic Conversion of mitochondrial DNA methylated, DNase I-resistant, 16 acid, 5388 S. cerevisiae, 1530 Chromatin assembly cis regulation Copy choice nucleosome assembly, 2863 myosin light-chain 1/3 gene immunoglobulin heavy-chain simian virus 40 DNA, 2863 alternative splicing, 2133 switch recombination, 397 Chromatin structure cis-Acting DNA element Courtship rat, 3334 P-450c gene in rats, 1470 cell-cell interaction, 2202 S. cerevisiae cis-Acting elements mating, 2202 centromeres, 5721 rat, 3334 S. cerevisiae, 2202 nucleosome depletion, 5721 S. cerevisiae CAR] (arginase) gene COXSB tyrosine aminotransferase gene expression, 5087 S. cerevisiae cis-acting elements, 3334 tyrosine aminotransferase gene transcription, 5510 Chromatin-assembled DNA chromatin structures, 3334 upstream activation and repression potentiation, 3926 cis-Acting promoter elements elements, 5510 X. laevis vitellogenin Bl promoter, 3926 a-actin gene COX6 Chromatin-binding protein transcription regulation, 528 glucose repression, 1297 phosphoenolpyruvate carboxykinase cis-Acting regulatory elements, 6533 S. cerevisiae, 1297 extinction of gene expression, 3782 al-inhibitor III gene SNFI, 1297 Chromosomal destabilization rat hepatic transcription, 3483 SSN6, 1297 gene amplification, 3056 novel combination, 3483 CPI Chromosomal DNA cis-Regulating elements centromere-binding protein, 2458 c-myc gene 1 tropomysin gene splicing, 5036 S. cerevisiae, 2458 cells, 4899 CIT2 CpG-rich islands and genes replication origin, 4899 citrate synthase mouse, 605 Chromosomal position effect peroxisomal, 1399 surfeit locus, 605 foreign gene, 1192 S. cerevisiae, 1399 Creatine kinase mouse, 1192 Citrate synthase adenovirus Ela transforming domains, Chromosome CI72, 1399 1476 human peroxisomal, 1399 induction of expression by adenovirus alpha satellite DNA, partial deletion, S. cerevisiae, 1399 EIA, 1476 6374 CKA2 Creatine kinase gene, brain centromere protein CENP-B, 6374 S. cerevisiae, 4089 rat rearrangement, mitotically stable, 6374 Clathrin-associated protein complexes cis-acting regulatory elements, 6533 P. berghei 1 chain, mammalian promoter region, 6533 size polymorphism, 6759 homolog, 6089 Creatine kinase genes telomeres, long insertions within, 6759 CLN gene brain, 4826 premature chromosome condensation, S. cerevisiae muscle, 4826 577 cell cycle arrest, 6482 TA-rich recognition protein-binding reg- RCCI gene, 577 mating-pheromone signalling pathway, ulatory elements, 4826 tsBN2 gene, 577 6482 CREB vitellogenin genes, activation START-I arrest, 6482 Xenopus oocytes, 6674 Collagen activating transcription factor 43 yeast artificial C. elegans, 2081 complex formation, related polypep- human-derived insert, 4163 rol-1, 2081 tides, 6192 modification, 4163 sqt-J, 2081 activating transcription factor 47 transfer, 4163 Collagen type I heterotrimer correspondence, 6192 Chromosome 2 embryonic mouse development, 1452 cyclic AMP response element-binding human, 823 human-mouse interspecies, 1452 protein N-myc excision, 823 Colony-stimulating factor 1 human brain, preferentially expressed neuroblastoma cells, 823 murine macrophage cell line, 2991 in, 1347 Chromosome 6 receptor domain swapping, 4565 immunoglobulin kappa light-chain genes, tyrosine phosphorylation, 2991 Crithidia fasciculata 4314 Colony-stimulating factor 1 receptor miniexon gene locus, 615 mouse, 4314 GAP-associated proteins, 5601 retrotransposon replicating regions, early and late, 4314 GTPase-activating protein, 5601 rapidly rearranging, 615 xvi SUBJECT INDEX MOL. CELL. BIOL.

Cryptococcus neoformans var. neoformans Cyclic AMP-responsive element DdrasG gene URA5 gene c-fos, 2402 D. discoideum, 918 isolation, 4538 pancreatic islet cells regulation of expression, 918 marker for transformation, 4538 glucagon gene, rat, activation, 6799 Deletion-type hereditary persistence otA-Crystallin Cyclin gene erythroid-specific hypersensitive site, gene expression, 3700 binding of homeodomain proteins, 872 1382 mouse, 3700 D. melanogaster, 872 fetal hemoglobin, 1382 81-Crystallin enhancer expression during development, 872 Developmental regulatory gene lens-specific elements, 958 proliferating cell nuclear antigen gene, A. nidulans nonspecific elements, 958 872 initiator (Inr)-like elements, 4912 CSP-B cytotoxic serine protease gene structure, 872 repression, 4912 human CYPIAI gene upstream elements, 4912 T lymphocytes, 5655 transcriptional promoter, 5098 DhfrlRep-3 major promoter region transcriptional activation, 5655 CYP2EI gene mouse C-terminal domain rat, 4495 DNase I footprinting, 6003 oncostatin M transcriptional control, 4495 internal deletion mutations, 6003 growth-inhibitory activity, 1882 Cyprinus carpio linker-scanning mutations, 6003 CUP2 ,B-actin gene Diabetes DNA binding, 4778 regulation, 3432 induction in male transgenic mice, 1779 metal dependence, 4778 cyr6l expression, 3569 H-ras oncoprotein expression in S. cerevisiae, 4778 mouse, 3569 pancreatic 3-cells, 1779 single amino acid change, 4778 Cytochrome b locus Diacylglycerol production CYCI 0. berteriana, 2428 p2lras microinjection, 333 glucose repression, 1297 RNA editing, 2428 phosphatidylcholine metabolism, 333 S. cerevisiae, 1297 Cytochrome c oxidase X. laevis oocytes, 333 SNF1, 1297 presubunit Va, 1873 Dictyostelium discoideum SSN6, 1297 S. cerevisiae, 1873 cyclic AMP receptor Cyclic AMP mitochondrial import, 4984 pharmacologically distinct, 3297 analogs subunit Vaw leaderless form, 4984 regulation of gp8O expression, 3297 F9 teratocarcinoma cells, 391 Cytochrome P450d DdrasG gene glucose-induced hyperaccumulation rat regulation of expression, 918 S. cerevisiae, 4518 aryl hydrocarbon induction, 6765 discoidin I -y gene P450scc gene induction, 6013 increased precursor kNA processing, promoter elements, negative and posi- promoter elements mediating transcrip- 6765 tive, 4080 tion induction and repression Cytochrome P450IAI gene GTP-binding protein genes, 2367 D. discoideum, 4080 aryl hydrocarbon response element phosphodiesterase gene discoidin I y gene, 4080 DNA-binding factors, 6408 structure, 1921 retinoic acid Cytokine LD78 plasmid Ddp2 receptor a, 3, and -y mRNAs, 391 genes extrachromosomal replication, 3727 Cyclic AMP phosphodiesterase protein-tyrosine kinase genes cDNA, 2678 expression, 3646 developmentally regulated, 3578 cloning and expression, 2678 structure, 3646 SASI, 2367 human, 2678 human, 3646 SAS2, 2367 low-Km and rolipram-sensitive, 2678 Cytokine response element sequence similarity stimulation by transforming ras proteins, rat a,-acid glycoprotein gene, 3965 essential genes, 2367 1689 Cytokines S. cerevisiae, 2367 Xenopus oocytes, 1689 immediate-early response gene induc- Differentiation inducer Cyclic AMP receptor tion, 5830 hexamethylene bisacetamide, 3535 D. discoideum, 3297 Cytomegalovirus enhancer mouse erythroleukemia cells, 3535 pharmacologically distinct, 3297 transgenic mice, 4406 resistance and sensitivity regulation of gp8O expression, 3297 conversion, 3535 Cyclic AMP response element d20J Dihydrofolate reductase c-Jun, 1609 Aa2 chromosome, 501 HIPI, 653 mXBP/CRE-BP2, 1609 dilute locus deletion mutations, 501 promoter, 653 12-O-tetradecanoylphorbol-13-acetate mouse, 501 transcription initiation, 653 response element, 1609 D' core protein Dihydrofolate reductase amplicons Cyclic AMP response element-binding small nuclear ribonucleoprotein particle, Chinese hamster cell line protein 4480 methotrexate-resistant, 1338 CREB, 1347 DBF2 replication origins, 1338 human brain, preferentially expressed in, periodic expression in cell cycle, 1358 Dihydrofolate reductase gene 1347 with mouse, 1390 Cyclic AMP-dependent protein kinase product homologous protein promoter activity, 1390 binding of nuclear factors to cAMP regu- kinases, 1358 sequences downstream of transcription latory element, 3357 S. cerevisiae, 1358 initiation site, 1390 negatively charged side group, 1066 Ddp2 Dihydrolipoyl transsuccinylase phosphoenolpyruvate carboxykinase extrachromosomal replication S. cerevisiae, 4221 regulation of transcription, 3357 cis-acting element, 3727 Dilute locus deletion mutations phosphorylation, 3357 trans-acting factor, 3727 Aa2 chromosome, 501 reduced activity in S. cerevisiae, 4518 DDR48 d20J, 501 subunit association, 1066 function, 3174 mouse, 501 Cyclic AMP-dependent protein kinases mutagenesis, 3174 Dimorphic fungus interleukin- 1 S. cerevisiae, 3174 M. racemosus signal transduction pathway, 3824 structure, 3174 ras gene similarity in gene family, VOL. 10, 1990 SUBJECT INDEX xvii

6654 DNA unwinding alternate splicing, 910 DIN] SV40 origin auxiliary sequences, 1719 cyclin gene, 872 S. cerevisiae T-antigen binding, 1719 D. orena, 539 DNA damage induction, 5562 DNA-binding protein developmental expression, 3272 ribonucleotide reductase regulatory activation DNA sequences subunit, 5562 gamma radiation, 5279 closely related, 3272 RNR3, 5562 human cells, 5279 dpp protein, 2669 Diphtheria toxin A g-ene damage-specific, 2041 E74A transcription genetic ablation, 474 human, 5279 splicing precedes polyadenylation, transgenic mice, 474 immunoglobulin switch region-specific, 6059 Discoidin I -y gene 1714 Gsa forms, 910 D. discoideum, 4080 methylated heat shock cognate 4 gene, 3232 promoter elements, positive and nega- apolipoprotein(a) gene, human, 4957 hsc4, 3232 tive, 4080 sequence specific, 4957 hsp26 gene, 131 DMP1 gene mouse splenic B cells, 1714 human immunodeficiency virus type I S. cerevisiae novel gpl60 complementation of glycosylation-de- mouse albumin enhancer negative reg- Rev-dependent expression, 6152 fective hamster cells, 4612 ulatory element, 38% postinitiation transcriptional control, DNA primate cells 6041 amplification, 75 UV-irradiated, 2041 pre-rRNA carcinogen-induced DNA amplification, S. cerevisiae, 1743 transcription activation, 4667 75 SIN3-dependent, 1743 proliferating cell nuclear antigen gene, Chinese hamster cells, 75 T-cell receptor ,B enhancer, mouse, 5027 872 hormonal induction of transfected genes, transcriptional regulation, 1743 regulatory elements, 131, 206 625 DNase I hypersensitivity ribosomal protein mitochondrial chicken, 2774 function in mammalian cells, 4524 conversion, 1530 ,-globin locus, 2774 S14, 4524 S. cerevisiae, 1530 topoisomerase II sites, 2774 scaffold-attached regions stability Dog ARS elements, 5442 mammalian cells, 401 differentiation, 57 autonomous replication, 5455 methotrexate, 401 gene transfer nuclear scaffold binding, 5442 SV40 origin region overreplication, 75 retroviral vectors, 3268 S. cerevisiae, 5455 topology, 625 inositol 1,4,5-triphosphate, 57 X chromosome, 5455 DNA bending enhancement MDCK cells, 57 yeasts, budding and fission, 5442 RIP60 myoblasts, 3268 Sgs-3 glue gene dihydrofolate reductase origin of repli- myotubes, 3268 fine-structure mutational analysis, cation, 6236 phospholipid metabolism, 57 5991 DNA binding prostaglandin E2, 57 promoter elements, stage and tissue CUP2 Dolichol phosphate mannose synthase specific, 5991 metal dependence, 4778 S. cerevisiae, 4612 spacer promoters S. cerevisiae, 4778 glycosyl phosphatidylinositol mem- pre-rRNA transcription activation, estrogen receptor brane anchoring, 57% 4667 dimerization-defective mutants, 5529 N glycosylation, 57% spermatocytes, 131 DNA damage O mannosylation, 57% Ul 70K protein agents, 4630 Domain swapping gene expression, 2492 S. cerevisiae PHRI, induction of expres- CREB, 4565 gene structure, 2492 sion, 4630 Fos, 4565 urate oxidase gene DNA damage-inducible gene Jun, 4565 ecdysone repression, 5114 DDR48 Dorsal protein Malpighian tubules, expression in, function, 3174 Rel protein, 2840 5114 mutagenesis, 3174 vRel vermilion gene and mutant alleles structure, 3174 oncogenic transformation, 2840 structure, 1423 S. cerevisiae, 3174 dpp protein transcription, 1423 DNA excision repair D. melanogaster, 2669 Drosophila orena ERCC-6, 5806 DRA promoter Adh gene promoters, 539 DINA methylation and demethylation cis-acting sequences, 711 D. melanogaster, 539 events trans-acting factor, 711 Drosophila sp. meiotic prophase in mouse testis, 1828 Drosophila cell lines even-skipped promoter, 4334 DNA replication Adh transcription Drosophila species chromosome enhancer and silencer elements, 3512 Al protein, 316 HeLa cells, 4899 Drosophila embryos Hrb98DE locus initiation zone, 4899 hsp7O promoter protein isoforms, 316 c-myc gene, 4899 polypeptide binding, 4233 ribonucleoprotein complexes, 316 DNA replication origin UV cross-linking, 4233 Duchenne muscular dystrophy gene Chinese hamster ovary cells, 4685 Drosophila melanogaster promoter region, 193 mapping, 4685 actin SC gene Duplication-induced mutation single-copy locus, 4685 distal promoter, 6172 N. crassa, 2638 DNA sequences regulatory elements, positive and neg- new gene required for acetate utilization, closely related, 3272 ative, 6172 2638 D. melanogaster actin 5C proximal promoter, 206 developmental expression, 3272 Adh gene promoters, 539 EIA DNA strand break repair Adh transcription adenovirus XRCCJ, correction by, 6160 enhancer and silencer elements, 3512 AP-1 transcription factor family, 5857 xviii SUBJECT INDEX MOL. CELL. BIOL.

ATF transcription factor Endothelium c-ERBB-2 E4F, 5138 immediate-early response gene, novel activation degradation sequence, 5609 cytokines, induction by, 5830 ,-casein gene, 4027 E4F transcription factor secreted protein, 5830 ERCC-3 ATF, 5138 tumor necrosis factor a, induction by, biological characterization, 2570 trans-activation, 5138 5830 human, 2570 HSP70 gene promoter substitution Enhancerlike positive regulatory element molecular cloning, 2570 mutants, 176 interleukin-2 receptor a-chain gene, 850 ERCC-6 human, 176 ENO] and EN02 enolase genes human Jun/Fos, 5857 S. cerevisiae DNA excision repair, 5806 TATA elements, 176 ABFI protein, 4872 molecular cloning, 5806 transactivation, 176, 5138 RAPI, repressor activator protein, Erythroblasts upstream elements, 176 4872 avian E2 transcription repression or activation, a-globin gene matrix attachment sites, bovine papillomavirus type I 4872 5349 transcription activation, 4431 upstream activation sites, 4872 Erythrocytes E4F transcription factor EN02 gene avian EIA S. cerevisiae a-globin gene matrix attachment sites, ATF, 5138 GCRI gene, 4863 5349 trans-activation, 5138 repression, 4863 Erythroid cell nuclear factors E74A upstream activation site, 4863 a-globin gene transcription regulation, D. melanogaster Enolase genes 5958 splicing precedes polyadenylation, S. cerevisiae Erythroid transcription factor GATA-1 6059 ENO] and EN02, 4872 expression transcription, 6059 ephlelk mouse, developing, 65% Ecdysone protein-tyrosine kinase family, 6316 Erythroid-specific hypersensitive site D. melanogaster Epidermal growth factor deletion-type hereditary persistence, urate oxidase gene repression, 5114 activation 1382 eck ,-casein gene, 4027 fetal hemoglobin, 1382 protein-tyrosine kinase epidermal growth factor-receptor com- Erythroleukemia ephlelk family, 6316 plexes Friend virus-induced, 3307 epithelial cell receptor, 6316 A-431 cells, internalization, 5011 p53, inactivation of, 3307 Effector cells functional state, 5011 Erythroleukemia cells c-fgr, 1789 intermolecular autophosphorylation of differentiation, 705 human, 1789 EGF receptors, 4035 differentiation inducer resistance and natural immunity, 1789 Epidermal growth factor receptor sensitivity Egr-1 gene product activation, 3048 conversion, 3535 characterization, 1931 activity ,-globin promoter DNA-binding zinc finger protein, 1931 regulation, 2749 transcription regulation, 972 identification, 1931 adenovirus hexamethylene bisacetamide, 3535 Elastases membrane-associated protein, 5521 mouse, 705, 972, 3535, 3952 biosynthesis c-myb transgene, 705 arterioles, 4596 inhibition, 1254 Erythroleukemia differentiation transforming growth factor a processing, pp60v-src, 1254 inhibition 4596 carboxy-terminal domain, 2749 leucine zipper, 5333 Embryonic stem cell differentiation cytoplasmic domain mutations, 3048 c-Myc, 5333 small nuclear ribonucleoprotein particle down regulation, 5521 Erythroleukemic cell lines protein erbB-2, 2749 a- and ,B-globin genes SmN, 6817 phospholipase C-y association, 435 differential expression, 3591 Emphysema rat tissue, 2973 mouse, 3591 al-antitrypsin Mminerai springs allele, 47 retrovirus-mediated gene transfer, 5521 Erythropoiesis human, 47 transformation mouse, developing, 6596 Endonuclease ligand-independent, 3048 Erythropoietin gene group I intron truncated, secreted form, 2973 cis-acting regulatory elements, 930 homing of, 3386 tyrosine kinase activity, 435 expression in transgenic mice, 930 intron-encoded, 3386 tyrosine kinase function, 2749 human, 930 I-Ppo, 3386 Epidermal growth factor-receptor com- transcription initiation sites, 930 P. polycephalum ribosomal DNA, 3386 plexes Erythropoietin receptor gene Endoplasmic reticulum A-431 cells, internalization, 5011 mouse, 3675 interacting genes required for transport functional state, 5011 structure, 3675 3405 Epithelial cell line BET], YPTl/SEC4-related cDNAs transcription, 3675 BOSI, 3405 cloning, 6578 Escherichia coli SEC22, 3405 Epithelial cell receptor ACEI transcription factor, 426 S. cerevisiae, 3405 protein-tyrosine kinase amber suppressor in S. cerevisiae, 1633 protein import, 6024 eck, cDNA cloning and characteriza- aminoacyl-tRNA synthetase, 1633 Sec62p, 6024 tion, 6316 SS ram protein transport to Golgi complex, 3405 ephlelk family, 6316 S. cerevisiae ribosomal protein, se- Endoplasmic reticulum protein erbB-2 quence and functional similarity, (l-*6)-P-D-glucan synthesis, 3013 carboxy-terminal domain, 2749 6544 KRE5 gene, 3013 epidermal growth factor receptor, 2749 S. cerevisiae metallothionein probable, 3013 regulation, 2749 gene transcription, 426 S. cerevisiae, 3013 tyrosine kinase function, 2749 upstream activation sequences, 426 VOL. 10, 1990 SUBJECT INDEX xix

Estradiol fer epidermal growth factor stimulation minivitellogenin mRNA, 371 mouse, 146 stromelysin mRNA, 4284 X. laevis, 371 protein, 146 promoter plasmids Estrogen-mediated stabilization spermatogenesis, 5021 NIH 3T3 cells, v-raf transformed, minivitellogenin mRNA, 371 testis-specific transcript, 146 6073 X. laevis, 371 testis-specific transcript (ferT), 5021 transcriptional activity, altered, 6073 Estrogen receptor Ferric reductase serum response factor, 5553 chromosomal vitellogenin genes, activa- iron uptake, 2294 transcription inhibition tion, 6674 S. cerevisiae, 2294 phospholipase C-type reaction inhibi- dimerization-defective mutants K-fgf tor, 5553 22-amino-acid peptide, 5529 embryonal carcinoma cells, 2475 c-fos induction DNA-binding activity, 5529 expression, 2475 basic fibroblast growth factor, 1556 transcription mechanism regulatory elements, 2475 nerve growth factor, 1556 cell-free system, 6607 c-fgr PC12 cell line, 1556 Estrogen receptor-dependent transcription effector cells N-ras, 1556 cell-free system, 6607 natural immunity, 1789 c-fos regulation ETS-2 protein human, 1789 c-jun regulation, 3185 phosphorylation, 1249 Fibrillarin liver T-cell antigen receptor-CD3 complex autoimmune disease, 430 regenerating, 3185 regulation, 1249 X. laevis, 430 mouse, 3185 Eucaryotic translation initiation factors 4A Fibroblast growth factor c-myc regulation, 3185 and 4F acidic and basic v-fos RNA helicase activity, 1134 receptor, diverse forms, 4728 rat fibroblasts Euplotes crassus Fibroblast growth factor, acidic revertants, 5626 telomere acidic fibroblast growth factor, 4770 transformation composition, 3421 heparin-binding growth factor 1, 4770 suppression, dominant, 5626 DNA-protein interactions, 3421 phospholipase C-y, 4770 c-fpslfes structure, 3421 Fibroblasts human, 2521 telomere-binding protein, 3421 proliferation mouse, 2521 Even-skipped promoter adenovirus early region 1, mainte- myeloid expression, 2521 Drosophila sp., 4334 nance by, 6664 Friend virus-induced erythroleukemia factor-binding sites, 4334 simian virus 40, conditional immortal- p53 transcription, 4334 ization, 6664 inactivation, 3307 Evi-J myeloid transforming gene rat Frog zinc finger protein v-fos transformed, 5626 UBF homologs, 3810 DNA-binding activity, 1259 suppression of transformation, domi- xUBF identification, 1259 nant, 5626 DNase footprints, 3810 nuclear localization, 1259 Fibronectin fyn gene Evi-2 human, 662 avian retroviruses, 3095 integration site, 4658 IIICS mRNA variant expression, 662 chicken embryo fibroblast cells murine myeloid leukemogenesis, 4658 Flagellar pocket protein transformation, 3095 Excision repair T. brucei, 4506 human, 3095 UV-irradiated plasmids, 3505 FLP protein transforming activity, 3095 X. laevis oocytes, 3505 Holliday structures, 235 235 Exon site-specific recombination, phase RNAs with multiple exons, 84 Fluorescence-based system for assaying G, splice site selection, 84 and separating live cells antigen receptor, 3003 Extracellular matrix proteins VDJ recombinase, 1697 B lymphoma cells, 3003 albumin gene transcription c-fms proteins cell cycle arrest, 3003 induction, 1239 expression in FDC-PI and BALB/c 3T3 restriction point, 3003 hepatocytes, 1239 cells, 2528 G,-S-phase-regulated region Extrachromosomal DNA tyrosine phosphorylation human, 3834 P. yoelii macrophage colony-stimulating factor- thymidine kinase gene promoter, 3834 mitochondrial functions, 6381 induced, 2528 G2 arrest fos S. cereW'siae F9 teratocarcinoma cells AP-1 site homology, 6273 rad mutants, 4678 cyclic AMP analogs, 391 cell type-specific transcriptional prop- UV damage repair, 4678 differentiation erties, 6273 UV irradiation, 4678 retinoic acid, 5883 C terminus G25K cDNA CArG elements, 4243 human Spl, 5883 domain swapping, 4565 tissue plasminogen activator gene, S. cerevisiae CDC42 homolog, 5977 Jun cooperation G 5883 heterologous activation domains, 5532 protein retinoic acid transcriptional regulation, 5532 coupling, 3117 receptor a, f3, and y mRNAs, 391 repression, 4243 phosphoinositide signaling pathways Farnesyl cysteine C-terminal methyltrans- transcriptional activation, 4243 oncogenes, 3117 ferase c-fos transformed cells, 3117 S. cerevisiae chromatin structure S. cerevisiae STE14 gene product dependence, 5071 DNase I sensitivity, 1126 pheromone response, 4439 Farnesyl pyrophosphate synthetase reversible changes, 1126 G protein subunits mRNA, 2315 cyclic AMP-responsive element, 2402 mating pheromone rat, 2315 enhancer signal transduction pathway, 510 transcription initiation sites, 2315 serum stimulation, 1126 S. cerevisiae, 510 xx SUBJECT INDEX MOL. CELL. BIOL.

GAL] promoter binding site mutations, 5077 ,B-Globin gene S. cerevisiae optimal half-site for binding, 5077 chicken, 16, 2774 glucose repression, 4757 GCN4 expression chromatin GAL4 GCN2 protein kinase methylated, DNase I-resistant, 16 phosphorylated, 4623 positive-acting domains, 2820 DNase I-hypersensitive sites, 2774 transcription activation, 4623 S. cerevisiae, 2820 topoisomerase II sites, 2774 GAL4 protein GCN4 mRNA transcription, 16 association with GAL80 protein, 2916 translational activation e-Globin gene conserved domain structure, 2916 uncharged tRNAs, 4375 Alu repetitive element, 1209 purification, 2916 GCRI gene DNase I-hypersensitive sites, 1199 S. cerevisiae, 2916 S. cerevisiae human, 1199, 1209 GAL4-binding sites EN02 repression, 4863 negative regulation, 1209 S. cerevisiae, 1432 EN02 upstream activation site, 4863 promoters, 1199 S. pombe transcription factor PGA4, null mutation, 4863 Globin gene expression 1432 GCRI product P-globin 3' enhancer, 1116 GAL80 protein ADH1 gene, 859 G-y-globin promoter elements, 1116 association with GAL4 protein, 2916 S. cerevisiae, 859 stage-specific, 1116 GAL genes TUF/GRF/RAP binding sites, 859 a- and ,-Globin genes S. cerevisiae gcr2 differential expression, 3591 UASG, opposing transcriptional regu- S. cerevisiae murine erythroleukemic cell lines, 3591 latory elements, 5663 glycolytic gene expression, 6389 P-Globin promoter Galactose GDI transcription in murine erythroleukemia metabolic pathway primary structure, 4116 cells, 972 mouse liver cells, 4582 smg p25A regulatory protein, 4116 (-Globin variants, 4582 Gene amplification human, 282 Ga chromosomal destabilization, 3056 NF-E1, 282 hybrid mammalian-yeast Ga proteins, serial selection promoter 2582 base substitutions, increased rate, protein-DNA interactions, 282 pheromone response 6805 Spl displacement, 282 signal transduction pathway, 2582 hamster mutator strain, 6805 Glucagon S. cerevisiae, 2582 Gene transfer p38 y2A gene expression infection, 4239 enhanced phosphorylation, 2468 heavy-chain enhancer, 1076 retrovirus vectors, 4239 rat liver cells, 2468 Gamma globin gene mutation Genetic ablation Glucagon gene human, 95 transgenic mice rat Spl binding activity enhancement, 95 diphtheria toxin A gene, 474 cyclic AMP-responsive element in Gamma radiation Germ line immunoglobulin a heavy-chain pancreatic islet cells, 6799 DNA-binding protein activation, 5279 RNA transcriptional activation, 6799 human cells, 5279 polysome, 382 (I--+6)-P-D-Glucan synthesis Gap junction protein endoplasmic reticulum protein, 3013 GHF-I 3013 connexin43 phosphorylation, 1754 growth hormone gene promoter KRE5 gene, mouse fibroblasts, 1754 S. cerevisiae, 3013 vole fibroblasts transcription stimulation, 1811 Glucocorticoid receptor uninfected and RSV-transformed, 1754 Spl, 1811 mouse, 4574 GAP-associated proteins Giardia lamblia nt' colony-stimulating factor-1 receptor, G. lamblia RNA virus amino-terminal transcriptional modula- 5601 RNA transfection, 3659 tory domain, 4574 GTPase activity protein, 5601 Giardia lamblia RNA virus Glucocorticoid receptor gene phosphatidylinositol kinase, 5601 G. lamblia, 3659 human gas gene RNA transfection, 3659 consensus glucocorticoid receptor ele- membrane protein, 2924 GLI ment sites, 5580 GATA-1 GLI3 190-kilodalton protein similarity, exon, first untranslated, 5580 expression 5408 GC rich, 5580 mouse, developing, 6596 GLI3 promoter, 5580 GATA-binding protein, nonerythroid 190-kilodalton protein Glucocorticoid response unit endothelial cells, 4854 GLI similarity, 5408 characterization, 4712 human, 4854 GLI gene phosphoenolpyruvate carboxykinase preproendothelin-1 promoter, 4854 human, 634 gene, 4712 GC box nuclear protein binding specific Glucocorticoid-induced cell death, 4574 TATAA-less promoter, 6632 sequences, 634 Glucocorticoids transcriptional activation, 6632 interleukin-1 stimulation of angiotensino- P-Globin 4389 GCN2 protein kinase domain gen gene transcription, GCN4 expression, 2820 interleukin-6 promoter positive-acting domains, 2820 nuclease-hypersensitive sites, 4324 enhancer occlusion, 5736 S. cerevisiae, 2820 human, 4324 Inr motif occlusion, 5736 GCN4 Globin chains repression, 5736 activation, 4256 expression RNA start site occlusion, 5736 nucleosome-positioning sequence, 4256 mouse, developing, 6596 TATA box occlusion, 5736 TATA element, 4256 a-Globin gene Glucose GCN4 activator protein transcription regulation defective repression in S. cerevisiae, S. cerevisiae erythroid cell nuclear factors, 5958 4518 ATF/CREB-like repressor binding site in vitro, 5958 induction of cyclic AMP hyperaccumula- similarity, 5077 promoter elements, 5958 tion in S. cerevisiae, 4518 VOL. 10, 1990 SUBJECT INDEX xxi

Glucose repression mouse hematopoietic progenitor cell dif- posttranscriptional regulation, 2687 S. cerevisiae GAL] promoter, 4757 ferentiation, 4846 S. cerevisiae, 2687 Glucose transport gro trans-activator protein S. cerevisiae human viral, 3258 HXT2 gene, 5903 cloning, 55% transcription inhibition, 3258 Glucose transporters leukocytes, 55% H2B histone gene LLC-PK1 cells monocytes, 55% sea urchin embryo D-glucose and monosaccharides, ef- sequencing, 55% 3' enhancer element, unusual, 6730 fects of, 6491 wound tissue, 55% late activation, 6730 Glutamic acid decarboxylase Growth arrest-specific gene H-2KItw' region rat gas histidine-rich charge clusters, 138 neurotransmitter synthesis, 4701 membrane protein, 2924 mouse, 138 testis, 4701 mouse fibroblasts, 1525 transmembrane protein, 138 Glutathione S-transferase Ya gene regulation, 1525 H4 upstream elements, 1841 Growth factor receptor target histone Glycerol-3-phosphate dehydrogenase pro- pp85, 2909 HML mating type locus, silent, 4932 moter Growth factor-inducible gene point mutations, 4932 human, 5244 cyr6l, 3569 S. cerevisiae, 4932 mouse, 5244 mouse, 3569 Hl9 gene product sequence conservation, 5244 Growth hormone mouse, 28 structural organization, 5244 gene promoter Hamster Glycolytic gene expression transcription stimulation, 1811 herpes simplex virus type 2 transformed S. cerevisiae GHF-1, 1811 cells, 4412 gcr2 mutation, 6389 Spl, 1811 neuropathological features, 1153 Glycoprotein Growth hormone gene premature chromosome condensation, novel recycling transmembrane, 2606 rat 577 p60v_src, 830 promoter, 5378 proteins, 1153 p180, 2606 Z-DNA, 5378 RCC1 gene plasma membrane matrix, 830 Growth stimulation point mutation, 577 Glycoprotein tyrosine phosphorylation ornithine decarboxylase gene expres- scrapie, 1153 chicken embryo fibroblasts, 837 sion, 5525 serum amyloid A protein-related mR- Rous sarcoma virus transformation, 837 G, protein NAs, 4412 Glycosomes adenylyl cyclase stimulation, 2931 tsBN2 gene, 577 T. brucei a subunit Hamster mutator strain 3-phosphoglycerate kinase import as- mutation, 2931 base substitution, increased rate, 6805 say, 4545 attenuator function, 2931 gene amplification, serial selection for, Glycosyl phosphatidylinositol Gsa forms 6805 S. cerevisiae alternate splicing, 910 Haptoglobin gene dolichol phosphate mannose synthase, D. melanogaster, 910 interleukin-6- and dexamethasone- 5796 Gs-a RNA responsive element membrane anchoring, 5796 nerve growth factor regulation, 3277 hormonal regulation, 1573 Golgi complex pheochromocytoma 12 cells, 3277 identification, 1573 interacting genes required for transport GTPase-activating protein structure, 1573 BET], 3405 colony-stimulating factor-1 receptor, rat, 1573 BOSI, 3405 5601 interleukin-1 and interleukin-6 re- SEC22, 3405 GAP-associated proteins, 5601 sponse elements, 5967 S. cerevisiae, 3405 human, 2901 H+-ATPase transport from endoplasmic reticulum, inhibition fibroblasts 3405 lipids, 6683 pH homeostasis, 4110 gp8O NIH 3T3 cells, serum stimulation, transformation, 4110 regulation of expression 6683 genetic analysis, 3737 cyclic AMP receptor, 3297 phosphatidylinositol kinase, 5601 S. cerevisiae vacuolar network, 3737 D. discoideum, 3297 raplA regulation, 2901 vacuolar acidification Granulocyte colony-stimulating factor raplA/Krev-1, 2901 role in protein sorting and zymogen granulocyte-macrophage colony-stimulat- GTP-binding protein genes activation, 3737 ing factor receptor, induction of, D. discoideum, 2367 yeast, 4110 4846 SASI, 2367 hck gene mouse hematopoietic progenitor cell dif- SAS2, 2367 mouse, 4603 ferentiation, 4846 sequence similarity promoter region promoter, 2002 essential genes, 2367 functional analysis, 4603 regulatory elements, 2002 S. cerevisiae, 2367 sequence, 4603 Granulocyte-macrophage colony-stimulat- Heat shock ing factor S. cerevisiae HSP26 promoter activity H2A transcriptional derepression, 6362 CATT(AtT) repeat requirement, 6084 S. cerevisiae Heat shock cognate 4 gene Granulocyte-macrophage colony-stimulat- growth requirement, 4905 characterization ing factor gene ubiquitination site, conserved, 4905 developmental, 3232 NF-KB H2A. I molecular, 3232 transcriptional activator, 1281 histone, 2848 D. melanogaster, 3232 Granulocyte-macrophage colony-stimulat- mRNA, 2848 hsc4, 3232 ing factor receptor H2B Heat shock element granulocyte colony-stimulating factor, cell growth inhibition, 3258 heat shock factor induction by, 4846 mRNA DNA binding, 1600 xxii SUBJECT INDEX MOL. CELL. BIOL.

transcriptional activation, 1600 Hemopoiesis Hexose transporters murine erythroleukemia cells, 1600 mouse blastocysts insulin receptor, 743 Heat shock factor interleukin-6 gene, 4953 insulin signaling pathway, 743 activation, 752 leukemia inhibitory factor gene, 4953 X. laevis, 743 heat shock element Hemopoietic cells HIPI DNA binding, 1600 octamer-binding genes, 1293 dihydrofolate reductase promoter, 653 murine erythroleukemia cells, 1600 Hemopoietic growth factor gene transcription initiation, 653 transcriptional activation, 1600 regulatory element, 2950 his3 Heat shock protein tumor necrosis factor-responsive tran- S. cerevisiae, 2832 85-kilodalton heat shock protein, 273 scription factor, 2950 transcription in vitro, 2832 A. ambisexualis, 273 Heparin-binding growth factor I HIS3 gene Chinese hamster ovary cells fibroblast growth factor, acidic, 4770 S. cerevisiae microtubule inhibitor-resistant mu- phospholipase C-y, 4770 Tc, 4447 tants, 5160 tyrosine kinase activation, 4770 Histone HSP70, 1622, 5160 Hepatitis B virus enhancer H2A.1 mRNA, 2848 hsp85, 273 C/EBP, 4427 H2B S. cerevisiae, 1622 functional organization, 3683 cell growth inhibition, 3258 self-regulation, 1622 rat liver, 4427 transcription inhibition, 3258 steroid hormone Hepatitis delta virus H2B gene receptor complex, 273 RNA self-cleavage 3' enhancer element, unusual, 6730 regulation, 273 conformational requirements, 5575 late activation, 6730 Heat shock protein family Hepatocellular carcinomas sea urchin embryo, 6730 70-kilodalton. 1234 mouse trans-activator protein calmodulin-binding domain, 1234 chemically induced, 5728 viral, 3258 Heat shock (stress) protein, small mdr3 overexpression, 5728 Histone gene chicken multidrug resistance gene overexpres- induction induction, 4886 sion, 5728 S. cerei'siae, 6356 posttranscriptional regulation, multi- spontaneous, 5728 stationary-phase cells, stimulation of, level, 4886 Hepatocytes 6356 Heavy-chain antibody albumin gene transcription rat, 585 variable-region genes, rearranged induction, 1239 testis-specific H2B (TH2B) mutation distribution, 5187 DNA-mediated gene transfer, 689 regulatory elements, 585 HeLa cell nuclei extracellular matrix proteins, 1239 Histone H2A protein kinase, DNA activated, 6460 rat, 689 S. cerevisiae HeLa cells Hepatoma cells growth requirement, 4905 c-myc gene human ubiquitination site, conserved, 4905 chromosomal DNA replication initia- alcohol dehydrogenase gene trans acti- Histone H4 gene tion, 4899 vation, 5007 S. cerevisiae poliovirus-infected C/EBP molecules, 5007 HML mating type locus, silent, 4932 TFIIIC modification, 5106 TATA box, 5007 point mutations, 4932 Helix-loop-helix protein Herpes simplex virus type 1 HL-60 leukemia cells immunoglobulin E box-binding proteins, transactivator Vmw65 doxorubicin resistance, 5541 4384 Oct-I, 4974 Spl transcription factor Hemagglutinin-neuraminidase protein-DNA complex assembly, 4974 DNA-binding activity, 5541 assembly, 1989 HERV-R mRNAs expression, 5541 folding, 1989 down regulation, 4401 HL-60 myeloid leukemia cells glycoprotein human choriocarcinoma, 4401 differentiation Newcastle disease virus, 449 zinc finger protein, 4401 retinoic acid-induced, 2154 glycosylation, 1989 Heteroduplex formation RARa, 2154 N-linked oligosaccharide chains, 1989 dispersed repeated genes retinoic acid, 2154 simian virus 5, 1989 meiotic recombination, 4420 HLA-H transport, 1989 S. cerevisiae, 4420 human, 243 Hematopoietic cells Heterogeneous nuclear ribonucleoprotein HML transforming growth factor ,31 C protein S. cerevisiae, 409 phorbol ester-regulated ribonuclease polyadenylation signal, downstream ele- HMR system, 5983 ment S. cerevisiae, 409 Hematopoietic stem cells uridylate tract substitution. 6397 HO Ly6E/A differentiation antigen RNA cross-linking S. cerevisiae interferon induction, 5150 uridylate tract mediation, 6397 SIN3, negative regulation by, 5927 promoter elements, 5150 Heterokaryons, transient HO nuclease recognition site Heme oxidase gene x-fetoprotein gene S. cerevisiae, 1174 human activation, 5047 HOLI mutations fibroblasts, skin, cultured, 4967 regulatory elements, 5047 ion transport, 643 oxidant stress, 4967 Heterologous activation domains S. cerevisiae, 643 transcriptional activation, 4967 Fos, 5532 Holliday structures Hemoglobin Jun, 5532 FLP protein-promoted site-specific fetal Hexamethylene bisacetamide recombination, 235 deletion-type hereditary persistence, differentiation inducer resistance and Homeobox 1382 sensitivity Xhox 36 transcripts in Xenopus embryos erythroid-specific hypersensitive site, conversion, 3535 homeodomain protein, 3376 1382 mouse erythroleukemia cells, 3535 noncoding, 3376 VOL. 10, 1990 SUBJECT INDEX xxiii

Homeodomain protein hsp85 protein, 1347 noncoding, 3376 A. ambisexualis, 273 brain, preferentially expressed in, 1347 Xhox 36 transcripts in Xenopus em- steroid hormone DNA-binding protein bryos, 3376 receptor complex, 273 activation, 5279 Homologous junctions regulation, 273 gamma radiation, 5279 nonconservative HSP86 methylated, 4957 mammalian cells, 6613 mouse sequence specific, 4957 Homologous recombination male germ cells, 3239 Ela transactivation, 176 human B cells, 3690 HT29 colon cancer cells effector cells hybridoma cells, 4466 protein kinase C overexpression natural immunity, 1789 immunoglobulin D switching, 3690 growth inhibition, 4650 emphysema, 47 mammalian cells, 6613 tumor suppression, 4650 endothelial cells Homologous recombination enhancement Human GATA-binding protein, nonerythroid, simian virus 40 T antigen, 794 adenosine deaminase gene 4854 Z-DNA motif d(TG)30, 794 exon 1, 4555 preproendothelin-l promoter, 4854 Hormonal induction transcriptional arrest sites, 4555 ERCC-3 transfected genes albumin gene, 1461 biological characterization, 2570 DNA topology, 625 binding of a liver-specific factor, 991 molecular cloning, 2570 Hormones al-antitrypsin deficiency, 47 ERCC-6 a-fetoprotein gene promoter repression, al-antitrypsin Minr springs allele, 47 DNA excision repair, 5806 5002 a-fetoprotein gene, 1461 molecular cloning, 5806 antihormones, 5002 Alu subfamily, transpositionally and erythropoietin gene chimeric receptors, 5002 transcriptionally competent, 5424 cis-acting regulatory elements, 930 HPRI amphiregulin gene, 1%9 expression in transgenic mice, 930 intrachromosomal excision recombina- amylase gene complex transcription initiation sites, 930 tion, prevention of, 1439 evolution, primate, 2513 c-fgr, 1789 S. cerevisiae, 1439 apoB fibroblasts, 1982, 3818 Hrb98DE locus promoter elements, 2653 fibronectin IIICS mRNA variant Al protein, 316 transcription, 2653 expression, 662 Drosophila species, 316 apolipoprotein(a) gene G,-S-phase-regulated region, 3834 protein isoforms, 316 highly repeated sites, 4957 G25K cDNA ribonucleoprotein complexes, 316 autoimmune disease S. cerevisiae CDC42 homolog, 5977 hsc4 X. laevis fibrillarin, 430 gamma globin gene mutation, 95 characterization B cells, 3690 genomic footprinting, 2554 developmental, 3232 beta interferon gene GLI gene molecular, 3232 enhanson domains, synergism be- nuclear protein binding specific D. melanogaster, 3232 tween, 3987 sequences, 634 hsp26 gene beta interferon promoter activity, 854 6-globin gene D. melanogaster spermatocytes, 131 ,B-globin, 4324 Alu repetitive element, 1209 regulatory elements, 131 brain, 2035 DNase I-hypersensitive sites, 1199 S. cerevisiae C3 gene negative regulation, 1209 transcriptional derepression during 58-base-pair region, 6181 6-globin heat shock, 6362 synergistic inducibility by interleukin-l protein-DNA interactions, 282 hsp28 and -6, 6181 upstream promoter region, 282 mammalian, 1276 CACCC factor, 3838 glucocorticoid receptor gene phosphorylation, 1276 cAMP-regulated c-myc expression, 184 consensus glucocorticoid receptor ele- tumor necrosis factor, 1276 CCAAT-box-binding factor ment sites, 5580 hsp6O hsp70 promoter, stimulation of tran- exon, first untranslated, 5580 Z. mays mitochondrial chaperonin, 3979 scription from, 6709 GC rich, 5580 HSP70 cells and tissues promoter, 5580 gene promoter poliovirus receptor-related proteins, glucose transporter factor substitution, 165 heterogeneous expression, 5700 expression in chicken embryo gene promoter substitution mutants centromeres fibroblasts, 1301 Ela transactivation, 176 replication timing of associated DNA glycerol-3-phosphate dehydrogenase pro- human, 165, 176 sequences, 6348 moter, 0 TATA elements, 176 choriocarcinoma, 4401 sequence conservation with mouse TATA-dependent and TATA-indepen- chromosome 2, 823 promoter, 5244 dent interactions, 165 chromosome ends gro transcript upstream elements, 176 structure and variability, 518 cloning, 55% HSP70 gene chromosome rearrangement expression in leukocytes and wound S. cerevisiae, 3262 alpha satellite DNA, partial deletion, tissue, 55% SSA3 6374 sequencing, 55% transcriptional regulation, 3262 centromere protein CENP-B, 6374 hemato-lymphoid cell lines, 1680 HSP70 promoter mitotically stable, 6374 heme oxidase gene human, 3125 CREB, 1347 fibroblasts, skin, cultured, 4%7 CCAAT-box-binding factor, 6709 CSP-B cytotoxic serine protease gene oxidant stress, 4%7 interactions between TATA element and T lymphocytes, 5655 transcriptional activation, 4%7 other sequence elements, 1319 transcriptional activation, 5655 hepatocellular carcinoma, 3216 stress induction cyclic AMP phosphodiesterase hepatoma cells, 1461 basal promoter requirements, 3125 cDNA, 2678 alcohol dehydrogenase gene trans acti- TATA-dependent and TATA-indepen- cloning and expression, 2678 vation, 5007 dent function of basal and heat low-Km and rolipram-sensitive, 2678 C/EBP molecules, 5007 shock elements, 1319 cyclic AMP response element-binding rat haptoglobin gene, 5%7 xxiv SUBJECT INDEX MOL. CELL. BIOL.

TATA box, 5007 c-myc protein intron -1 element, 4990 HERV-R mRNAs autosuppression, 4961 transcriptional readthrough block, down regulation, 4401 ras cooperation, 4961 4990 zinc finger protein, 4401 c-myc RNA accumulation, 184 ras gene high-level-inducible gene expression sys- myosin M. racemosus gene family, similarity, tem, 6141 isoform evolution and function, 1095 6654 HLA-H, 243 light chains 1sa and 3nm, 1095 ras-like genes, 1793 HSP70 gene promoter nerve growth factor SCL gene factor substitution, 165 neuroblastoma cells, 5015 formation from a transcriptionally substitution mutants, 176 neuronal differentiation, induction of, complex locus, 6426 HSP70 promoter, 3125 5015 Spl binding activity enhancement, 95 CCAAT-box-binding factor, 6709 neuroblastoma cells, 361, 823 Spi displacement, 282 interactions between TATA element NF-EI, 282 C-SRC exon, 2035 and other sequence elements, NF-E1 erythroid-specific transcription src regulation, 1301 1319 factor, 3838 stress induction TATA-dependent and TATA-indepen- normal tissues, 2554 basal promoter requirements, 3125 dent function of basal and heat nucleolar antigen, 3253 synergy between NF-Ei and CACCC shock elements, 1319 nucleotide excision repair, 3945 factor, 3838 immunoglobulin D switching osteosarcoma cells, 184 TATA elements, 176 homologous recombination, 3690 p36 TATA-binding proteins initiator tRNA gene enhanced expression, 3216 specificity, 3859 expression and function in S. cerevi- p120, 3253 TATA-dependent and TATA-indepen- siae, 4486 P450scc gene dent interactions, 165 insulinlike growth factor I receptor over- 12-O-tetradecanoylphorbol- 13-acetate, T-cell line, 2164 expression repression by, 6013 T-cell receptor a gene neoplastic transformation, 464 A23187, repression by, 6013 enhancer elements, hypomethylated, interferon a-1 gene cis elements, independent, 6013 4720 regulatory proteins, putative, 2554 cyclic AMP, induction by, 6013 enhancer regulation, 4720 interleukin-2 gene promoter PCNA regulation, 303 nuclear proteins, T-cell specific, 4720 activation, 5464 phosphatidylinositol-3 kinase T-cell receptor 1B gene Oct-2 expression, 5464 p59tfv, 3806 nuclear protein interaction, 5486 octamer-binding sites, 5464 p60c-src, 3806 T-cell receptor a gene, 5486 interleukin-6 induction thrombin-dependent association, 3806 transcriptional enhancer, 5486 interleukin-1, 3818 Pim-1 telomeres NF-KB-like factor, 3818 selective transcription of, 1680 tumor necrosis factor, 3818 placenta protein replication timing of associated DNA intrachromosomal homologous recombi- tyrosine phosphatase microinjection, sequences, 6348 nation 458 teratocarcinoma cell line, 1793 1-nitrosopyrene, 3945 Xenopus oocyte cell division, 458 thyroid epithelial cells UV, 3945 plastin isoforms immortalization, conditional, 5365 introns, 303 calcium-binding domain, potential, oncogene action, 5365 kappa light-chain enhancer 1818 thyroid peroxidase gene octamer-binding site, 3843 N-terminal sequences, 1818 thyroid-specific enhancer, 6216 lac operator-repressor system, 6141 platelet-derived growth factor, 184 transcription factor TFIID, partially pro- lamin B platelets, 3806 teolyzed in vitro modification, 2164 polymerase chain reaction, anchored, DNA-binding and transcriptional prop- LD78 genes 1818 erties, 3415 expression, 3646 1-polymerase promoter trk oncogenes structure, 3646 ras-responsive element, 3852 activation, 4202 leukemia T-cell lines porphobilinogen deaminase gene tyrosine kinase domain, 4202 p53 tumor suppressor gene mutations, erythroid-specific promoter, 3838 tumor necrosis factor-induced gene 5502 pp6Orc kinase activation, 361 sequences, 1982 leukocyte antigen class I gene, 243 priming, 854 type IV collagenase leukocyte antigen class II genes prolactin gene transcriptional elements, positive and B lymphocytes, 3792 expression, 4690 negative, 6524 transcription analysis using polymer- pituitary, 4690 upstream elements, 176 ase chain reaction, 3792 regulatory elements, 4690 wound tissue leukocytes proliferating cell nuclear antigen gene, gro transcript expression, 5596 gro transcript expression, 5596 303 XRCCI LINE-I promoter protein kinase, DNA activated gene cell specificity, 6718 human Ku autoantigen phosphoryla- DNA strand break repair correction, identification and characterization, tion, 6472 6160 6718 mouse p53 phosphorylation, 6472 molecular cloning, 6160 monocytes, activated simian virus 40 T antigen phosphoryla- sister chromatid exchange, 6160 gro transcript cloning and sequencing, tion, 6472 Z-DNA motif d(TG)30 5596 protein kinases A and C, 184 recombinational hotspot, 785 M-phase promoting factor Raf-l promoter region Human cell lines biosynthesis, 3847 molecular organization, 3325 nuclear factor I cell cycle, 3847 rapIA regulation multiple forms, 1041 p34, 3847 GTPase-activating proteins, 2901 Human immunodeficiency virus type I c-myb RNA raplA/Krev-1, 2901 gpl60 alternative splicing, 2715 c-Ha-ras Rev-dependent expression in D. mela- N-myc excision, 823 down regulation, 1461 nogaster cells, 6152 VOL. 10, 1990 SUBJECT INDEX xxv

Human leukocyte antigen heavy-chain E transcripts Insulinlike growth factor I receptor neuroblastoma cells expression, 1672 chicken cells transformed by src, 3626 N-myc, 5416 structure, 1672 overexpression somatic cell fusion, 5416 heavy-chain gene expression human, 464 Human T-cell leukemia/lymphoma virus regulation, 3155 neoplastic transformation, 464 type I I,u sterile transcription, 2619 phosphorylation, 3626 TAX, interleukin-4 and lipopolysaccharide- int-i promoter indirect interaction with long terminal directed switching to Cr, 1672 mouse mammary tumor virus, 4170 repeat, 4192 kappa Wnt-I promoter, 4170 Human T-lymphotropic virus type I germ line transcripts, 1950 int-i protein neoplastic transformation, 413 kappa light-chain genes, 4314 cell surface, 2723 ras oncogene, 413 light-chain gene mouse, 2723 rat embryo fibroblasts, 413 ongoing diversification, 3224 Interferon tax gene, 413 lymphoid-specific enhancer element, alpha, 5055 HXT2 gene 3155 gamma, 5055 S. cerevisiae mouse, 1950 gene induction by, 5055 glucose transport, high affinity, 5903 mouse chromosome 6 Ly6E/A differentiation antigen induction, Hybridoma cells replicating regions, early and late, 5150 homologous recombination, 4466 4314 c-Ha-ras gene expression, induction of, 3-Hydroxy-3-methylglutaryl coenzyme A mouse splenic B cells, 1714 4424 reductase p heavy-chain gene enhancer synergy, alpha and gamma, 5055 membrane topology, 672 regulation, 3145 trans-acting factors S. cerevisiae, 672 p.B, 3145 functional complementation, 5055 transmembrane domains, 672 OTF2, 2145 induction by alpha and gamma inter- Hypoxanthine-guanine phosphoribosyl- switch region-specific DNA-binding feron, 5055 transferase gene protein, 1714 Interferon a-i gene cis-acting element, 4356 Immunoglobulin a heavy-chain genes genomic footprinting, 2554 rat, 4356 germ line RNA, 382 human transcription polysome, 382 normal tissues, 2554 cell type-specific, 4356 Immunoglobulin D switching putative regulatory proteins, 2554 purine-mediated, 4356 homologous recombination, 3690 Interferon-regulatory factor I Hypoxic consensus operator human B cells, 3690 prolactin induction, 3087 S. cerevisiae Immunoglobulin 8 Interferon-stimulated gene factor 2 ANBI gene regulation, 5921 heavy-chain gene expression, 5340 cloning, 2448 Immunoglobulin gene transcription purification, 2448 IL6-PE40 octamer-binding protein, 982 Interleukin-1 cell-specific toxicity, 2443 Immunoglobulin X2-chain gene angiotensinogen gene transcription, stim- tumor cells, 2443 mouse ulation of IMEI nuclear protein interaction, 5894 glucocorticoids, role of, 4389 IME2, 2104 palindromic sequence, 5894 gene expression, 2731 S. cerevisiae, 2104 promoter, 5894 human C3 gene meiosis regulation, 6103 transcription, 5894 synergistic inducibility with interleu- sporulation-specific genes Immunoglobulin promoter kin-6, 6181 activation, 2104 transcription human fibroblasts, 3818 positive control, 2104 B-cell-specific component require- IL-I-inducible factors, 2757 IME2 ment, 6204 IL-I-responsive element, 2757 IMEI, 2104 octamer-binding transcription factors, induction, 2731 S. cerevisiae, 2104 6204 interleukin-6 gene, 2757 sporulation-specific genes Ip. sterile transcription interleukin-6 induction, 3818 activation, 2104 immunoglobulin heavy-chain enhancer, mouse factor B gene enhancement, 6283 positive control, 2104 2619 NFKB-like hepatoma nuclear factor, Immediate-early response gene Influenza virus 6283 endothelium AIWSN/33 phosphoinositide pathway agonists, syn- cytokines, induction by, 5830 polymerase basic protein 1, nuclear ergy with secreted protein, 5830 localization of, 4139 costimulation, molecular basis of, 6325 tumor necrosis factor a, induction by, Initiator (Inr)-like elements interleukin-2 gene induction, 6325 5830 A. nidulans, 4912 protein kinase C, 2731 Immortalization, conditional Inositol 1,4,5-triphosphate signal transduction, 2731 human thyroid epithelial cells, 5365 MDCK cells, 57 signal transduction pathway oncogene action, 5365 Insulin II gene cAMP-dependent protein kinases, Immunoglobulin rat, 1784 3824 bursal lymphoma cell line, 3224 sequence element cooperativity, 1784 Interleukin-l and interleukin-6 response E box-binding proteins tissue specificity, 1784 elements Insulin gene transcription factor rat haptoglobin gene helix-loop-helix protein, related, 4384 pancreatic ,-cells, 1564 hepatoma cells, 5967 y2A gene expression, 1076 Insulin receptor regulation, 5967 germ line, 1672 hexose transporters, 743 Interleukin-2 heavy-chain insulin signaling pathway, 743 tumor necrosis factor p expression, 5865 copy choice, 397 X. laevis, 743 Interleukin-2 gene promoter, 2145 Insulin signaling pathway induction switch recombination, 397 hexose transporters, 743 costimulation, molecular basis of, 6325 transcription, 2145 insulin receptor, 743 interleukin-l synergy with phosphoi- heavy-chain enhancer, 1076, 2619 X. laevis, 743 nositide pathway agonists, 6325 xxvi SUBJECT INDEX MOL. CELL. BIOL.

Interleukin-2 gene promoter Invariant chain KGD2 human major histocompatibility complex class regulation, 4221 activation, 5464 II genes, 3906 S. cerevisiae, 4221 Oct-2 expression, 5464 promoter and enhancer elements, 3906 structure, 4221 octamer-binding sites, 5464 transcriptional control, 3906 Killer virus K28 Interleukin-2 receptor Ion transport S. cerevisiae, 4807 a-chain gene HOLI mutations, 643 c-kit enhancerlike positive regulatory S. cerevisiae, 643 chimeric proto-oncogene element, 850 I-Ppo ligand-dependent transforming poten- Interleukin-4 and lipopolysaccharide- characterization, 3386 tial, 6064 directed switching to CE intron-encoded endonuclease receptor functions, 6064 germ line immunoglobulin heavy-chain group I intron, homing of, 3386 Kluyveromyces lactis £ transcripts P. polycephalum ribosomal DNA, 3386 LAC9 protein expression, 1672 IRA2 C6 zinc finger, 5128 structure, 1672 RAS, negative regulator of, 4303 DNA-binding specificity and affinity, Interleukin-6 S. cerevisiae, 4303 5128 gene expression Iron uptake KP6 killer toxin activation, 2327 ferric reductase, 2294 expression in S. cerevisiae, 1373 human C3 gene S. cerevisiae, 2294 relationship to other cellular toxins, 1373 synergistic inducibility with interleu- structure, 1373 kin-1, 6181 J774.2 cells U. maydis, 1373 NF-KB, 2327 mdrla KRE5 gene Interleukin-6- and dexamethasone-respon- structural analysis, 3596 endoplasmic reticulum protein, 3013 sive element transcript heterogeneity, 3596 (1-*6)-P3-D-glucan synthesis, 3013 hormonal regulation, 1573 mouse, 3596 S. cerevisiae, 3013 identification, 1573 P-glycoprotein, 3596 Krox-20 rat haptoglobin gene, 1573 Jun transcription initiation site, serum-re- structure, 1573 domain swapping, 4565 sponsive, 3788 Interleukin-6 gene Fos cooperation zinc finger gene, 3788 activation, 561 heterologous activation domains, 5532 Krox-24 interleukin- I transcriptional regulation, 5532 mouse, 3456 IL-1-inducible factors, 2757 c-jun transcriptional activator Krox-24, 3456 IL-i-responsive element, 2757 angiotensin II, induction by, 5536 Ku autoantigen leukemia inhibitory factor gene, 4953 Chinese hamster ovary cells human lymphokines protein synthesis-dependent mRNA phosphorylation, 6472 inflammatory, 561 increase, 5814 mouse blastocysts cyclic AMP response element, 1609 L2 ribosomal protein genes hemopoiesis, 4953 epidermal growth factor stimulation ABFI factor, 2437 NF-KB-like transcription factor, 561 stromelysin mRNA, 4284 S. cerevisiae, 2437 regulation, 2757 mXBP/CRE-BP2, 1600 L23 Interleukin-6 induction 12-O-tetradecanoylphorbol- 13-acetate human fibroblasts, 3818 response element, 1609 chicken embryo, 2562 interleukin-l, 3818 c-jun regulation myosin light-chain gene NF-KB-like factor, 3818 c-fos regulation, 3185 regulation, 2562 tumor necrosis factor, 3818 liver L30 Interleukin-6 promoter regenerating, 3185 ribosomal protein, 5235 glucocorticoids, repression by mouse, 3185 S. cerevisiae, 5235 enhancer occlusion, 5736 c-myc regulation, 3185 LAC9 protein Inr motif occlusion, 5736 Jun/Fos K. lactis RNA start site occlusion, 5736 AP-1 transcription factor family C6 zinc finger, 5128 TATA box occlusion, 5736 adenovirus EIA gene, 5857 DNA-binding specificity and affinity, Intermediate filaments 5128 adenovirus EIB proteins, 120 K28 lac operator-repressor system transformation, 120 S. cerevisiae derepression, 6141 Intron killer virus, double-stranded RNA, metallothionein-IIA promoter, human, 3' exon, 2960 4807 6141 3' splice site specificity, 2960 Kappa immunoglobulin positive induction by glucocorticoid and group I, 2960 germ line transcripts, 1950 metal ions, 6141 homing of, 3386 mouse, 1950 lac repressor internal guide sequence, 2960 Kappa immunoglobulin gene enhancers conversion to an activator, 3343 I-Ppo, 3386 class I mammalian cells, 3343 P. polycephalum ribosomal DNA, 3386 major histocompatibility complex rRNA enhancer-binding protein 1, 1406 Lactate dehydrogenase self-splicing, 2960 gene enhancers, 1406 PC12 pheochromocytoma cell nuclei, T. thermophila, 2960 zinc finger domain-containing protein, 770 U6 1406 phosphotyrosine, 770 evolutionary origin, 5548 Kappa light-chain enhancer Lamin B small nuclear RNA, 5548 human, 3843 human T-cell line, 2164 Intron-encoded endonuclease octamer-binding site, 3843 in vitro modification, 2164 group I intron Keratinocyte Ick mRNAs homing of, 3386 differentiation, 1164 mouse, 4266 I-Ppo, 3386 primary, 1164 T-cell maturation, 4266 P. polycephalum ribosomal DNA, 3386 tyrosine phosphorylation, 1164 types I and II, 4266 VOL. 10, 1990 SUBJECT INDEX xxvii

LD78 Lymphoma cell line conversion to an activator, 3343 expression, 3646 bursal, 3224 methotrexate, 401 human, 3646 immunoglobulin light-chain gene mRNA synthesis, 4529 structure, 3646 ongoing diversification, 3224 T3 RNA polymerase, 4529 Leishmania enrietii L YS5 Marker membrane transport protein Y. lipolvtica C. neoformans var. neoformans, 4538 structural isoforms, 6785 overlapping reading frames, 4795 URA5 gene, 4538 Leishmania major Lysozyme Mating pheromone transfection 5' matrix attachment region, 2302 G protein subunits, 510 stable, 1084 chicken, 2302 S. cerev'isiae, 510 Leucine zipper signal transduction pathway, 510 c-Myc Macrophage Mating response erythroleukemia differentiation inhibi- colony-stimulating factor 1 receptors cell cycle arrest, 217 tion, 5333 differentiation, 2703 S. cerevisiae, 217 Leukemia cells fms genes, 2703 STE4 overexpression, 217 HL-60 lineage switching, 2703 Mating-pheromone signalling pathway doxorubicin resistance, 5541 mouse, 2703 S. cerevisiae, 6482 Spl transcription factor, 5541 pre-B lymphoid cells, 2703 Mating-type genes Leukemia inhibitory factor gene tumor necrosis factor alpha transcription byri, 549 developmental expression, 3801 regulation rasi, 549 interleukin-6 gene, 4953 KB-like motifs, 1498 S. pombe, 549 mouse NF-KB forms, constitutive and induc- starvation-induced transcription, 549 extraembryonic tissue, 3801 ible, 1498 Matrix attachment region preimplantation blastocysts, 3801 Macrophage colony-stimulating factor chicken mouse blastocysts BALB/c 3T3 cells, 2528 lysozyme, 2302 hemopoiesis, 4953 FDC-PI cells, 2528 M-CAT binding factor Leukemia T-cell lines c-fms proteins, 2528 muscle-specific transcription, 4271 human tyrosine phosphorylation, 2528 mcm3 p53 tumor suppressor gene mutations, Macrophages S. cerevisiae 5502 B cells minichromosome maintenance mutant, LINE-l promoter mature, clonally related, 3562 5707 human transformation of murine bone marrow MDCK cells cell specificity, 6718 cells with v-raf-v-myc, 3562 differentiation, 57 identification and characterization, Maize transposable element inositol 1,4,5-triphosphate, 57 6718 Adh mutants phospholipid metabolism, 57 Lipopolysaccharide-unresponsive mutant polyadenylation, 2090 prostaglandin E2, 57 pre-B cells splicing, 2090 mdrl promoter NF-KB activation, 422 Mul, 2090 mouse Liver Major histocompatibility complex cell-specific activity, 6036 mouse H2.35 cell line class II elements and factors, 593 cis-acting elements, 6036 galactose metabolic pathway, 4582 class II genes mdrla promoter Liver-specific factor promoter and enhancer elements, 3906 5' and 3' transcript heterogeneity, 3596 avian very-low-density apolipoprotein class 1I promoters murine J774.2 cells, 3596 gene, 154 differential protein binding, %5 3596 developmental changes, 154 class II-associated invariant chain P-glycoprotein, LLC-PK, cells expression structural analysis, 3596 glucose transporters tumor necrosis factor a, 4146 transcript heterogeneity, 3596 D-glucose and monosaccharides, ef- mouse, 593 mdr3 multidrug resistance gene fects of, 6491 Major histocompatibility complex class I mouse Ltk- cells enhancer-binding protein 1, 1406 hepatocellular carcinomas, 5728 intermolecular recombination gene enhancers, 1406 overexpression, 5728 nonconservative, 103 kappa immunoglobulin gene enhancers, mdr gene family recombination models, 103, 113 1406 amplification, 1642 repair of double-stranded breaks, 113 transcription factor inactive in tumori- drug specificities, 1652 Ly6E/A differentiation antigen genic cells, 4100 mouse, 1642, 1652 hematopoietic stem cells, 5150 zinc finger domain-containing protein, multidrug resistance, 1652 interferon induction, 5150 1406 multidrug-resistant cells, 1642 promoter elements, 5150 mak overexpression, 1642 T cells, activated, 5150 mammalian protein kinase gene, 2261 physical mapping, 1642 Lymphoid transformation testicular germ cells, 2261 Megakaryocytopoiesis v-abl replacement MAL mouse bcrlabl, 4365 S. cerevisiae, 3797 cholinesterase gene expression, ma- myc, 4365 3797 nipulation of, 6046 ras, 4365 upstream activating sequence, 6046 src, 4365 MAL63 activator modulation, Lymphoid-specific enhancer element binding sites, 3797 Meiosis immunoglobulin heavy-chain gene S. cerevisiae, 3797 S. cerevisiae, 2809 expression Malpighian tubules IMEJ, 6103 regulation, 3155 D. melanogaster urate oxidase gene regulation, 6103 Lymphokines expression, 5114 SP012, 2809 inflammatory, 561 Mammalian cells SP016, 2809 interleukin-6 gene activation, 561 DNA stability, 401 Membrane attachment NF-KB-like transcription factor, 561 lac repressor src protein, 1000 xxviii SUBJECT INDEX MOL. CELL. BIOL.

Membrane topology Mitochondria deregulation, 1901 3-hydroxy-3-methylglutaryl coenzyme A mRNA-specific translational activator, blastocysts, 4953 reductase, 672 4590 bone marrow cells, transformation of, S. cerevisiae, 672 P. yoelii 3562 transmembrane domains, 672 extrachromosomal DNA, 6381 bovine papillomavirus type I DNA Membrane transport proteins S. cerevisiae replication, 3078 L. enriettii apoiso-l-cytochrome c, 5763 BXH-2 structural isoforms, 6785 apoiso-l-cytochrome c fusion protein, Evi-2, 4658 MERI 5753 myeloid leukemogenesis, 4658 chromosome pairing, 2379 ribosomal protein, 4590 ,B-casein gene genetic recombination, 2379 Mitochondrial DNA epidermal growth factor activation, S. cerevisiae, 2379 conversion, 1530 4027 Mesenchymal tissue mouse striated muscle c-ERBB-2 activation, 4027 ontogeny, 736 expression, 5671 lactogenic hormone induction, 4027 proenkephalin A, 736 structure, 5671 cell surface, 2723 rat, 736 [rho-], 10 chromosomal position effect, 1192 Metallothionein-IIA promoter S. cerevisiae, 10, 1530 chromosome 6 human Mitochondrial import replicating regions, early and late, high-level-inducible gene expression cytochrome c oxidase 4314 system, 6141 leader peptide requirement, 4984 chromosome 8 lac operator-repressor system, 6141 subunit Va, leaderless form, 4984 novel gene, 3663 Methotrexate S. cerevisiae, 4984 collagen I heterotrimer mammalian cells Mitochondrial inner membrane protein human-mouse interspecies, 1452 transfected DNA stability, 401 cytochrome c oxidase colony-stimulating factor I receptors, N6-methyladenosine presubunit Va, 1873 2703 prolactin S. cerevisiae, 1873 tyrosine phosphorylation, 2991 pre-mRNA, 4456 Mitochondrial RNA sequences colony-stimulating factor gene expres- Methylation patterns RNase MRP sion, 4948 mouse embryonic stem cells, 4396 site-specific cleavage, 2191 connexin43 gap junction protein Thy-l gene, 43% substrate recognition, 2191 fibroblasts, 1754 N-methyl-N-nitrosourea Mitogenic signal transduction phosphorylation, 1754 mouse mammary carcinogenesis, 1593 inhibition, 5314 vole fibroblasts, uninfected and RSV- c-Ki-ras, 1593 NIH 3T3 cells, 5314 transformed, 1754 transforming c-Ki-ras mutation, 1593 Ha-ras, 5314 c-rel protein Microtubule function Moloney murine leukemia virus C-terminal transcriptional transactiva- chromosome instability mutants, 223 embryonal carcinoma cells, 4045 tion domain, 5473 S. cerevisiae, 223 expression, 4045 N-terminal regulatory domain, 5473 Microtubule inhibitors NIH 3T3 cells aA-crystallin gene expression, 3700 Chinese hamster ovary cells chimeric tRNA-driven antisense tran- cyr6l expression, 3569 5160 scripts, 6512 developing hsp70, resistance, 6512 erythroid transcription factor GATA-1 major heat shock protein family mem- Mosquito expression, 6596 ber, 5160 retrotransposable element, 863 erythropoiesis, 65% resistant mutants, 5160 Mouse GATA-1 expression, 6596 Microtubules Abelson murine leukemia virus, 569 globin chain expression, 6596 S. cerevisiae adenosine deaminase gene DhfrlRep-3 major promoter region assembly, 5286 transcriptional arrest in exon 1, 1484 DNase I footprinting, 6003 tubulin regulation, 5286 adipogenic differentiation, 4948 internal deletion mutations, 6003 Middle-T antigen-tyrosine kinase complex albumin enhancer linker-scanning mutations, 6003 polyomavirus negative regulatory protein, 3896 diabetes induced in male transgenic cellular components, 5569 ao-antitrypsin gene mice, 1779 stoichiometry, 5569 highly conserved upstream regions, 760 differentiation inducer resistance and viral components, 5569 liver-specific expression, 760 sensitivity Minichromosome maintenance a1-protease inhibitor genes conversion, 3535 DNA replication-defective mutants, 5707 cis-acting elements, 2625 dihydrofolate reductase gene mcm3, 5707 negative and positive control, 2625 promoter activity, 1390 S. cerevisiae mcm3 mutants, 5707 axA-CRYBPl site sequences downstream of transcrip- Miniexon gene locus thymidine kinase promoter, species- tion initiation site, 1390 C. fasciculata, 615 specific lens activation, 6813 dilute locus deletion mutations tissue specificity, loss of by multimer- Aa2 chromosome, 501 retrotransposon ization, 6813 dj2OJ, 501 rapidly rearranging, 615 angiotensin-converting enzyme, 4294 DNA methylation and demethylation Minimal transforming sequence B2 transcripts, 4058 events, 1828 definition, 2503 B cells, 1950 DNA-binding protein c-raf-1 immunoglobulin M and D-expressing, immunoglobulin switch region-specific, mutational activation, 2503 1901 1714 Mini-Tyl elements splenic, mitogen-stimulated, 1714 drug specificities, 1652 S. cerevisiae, 2695 BALB 3T3 cells embryo, 2335 Tyl element transposition, 2695 mucAB, 5359 embryonal carcinoma cells, 4058 Minivitellogenin mRNA plasmid misrepair gene, enterobacte- embryonic stem cells, 4396 estradiol and estrogen receptor-depen- rial, 5359 N-myc allele, inactive, 6755 dent stabilization, 371 transformation, 5359 embryonic stem and pre-B cell lines, X. laevis, 371 Bcl-2-immunoglobulin transgene 1799 VOL. 10, 1990 SUBJECT INDEX xxix

erythroleukemia cell differentiation, 705 intermolecular recombination, 103 nt' mutant, 4574 erythroleukemia cells, 972, 1600, 3952 J774.2 cells, 35% p53 phosphorylation erythroleukemic cell lines, 3591 c-jun regulation, 3185 human protein kinase, DNA activated, erythropoietin receptor gene kappa immunoglobulin germ line 6472 structure, 3675 mRNAs, 1950 pancreatic mRNA synthesis, 254 transcription, 3675 Krox-24, 3456 P-glycoprotein promoter, 35% extraembryonic tissue, 3801 Ick mRNAs poly(A)+ RNA factor B gene types I and II, 4266 transcriptional machinery, reprogram- interleukin-l-mediated enhancement, leukemia inhibitory factor gene, 4953 ming of, 6055 6283 leukemia inhibitory factor gene, myeloid X. laevis oocytes, 6055 NFKB-like hepatoma nuclear factor, developmental expression, 3801 pre-B cells, 569 6283 liver pre-B lymphoid cells, 2703 fer protein, 146 galactose metabolic pathway, 4582 preimplantation blastocysts, 3801 fer testis-specific transcript, 146 H2.35 cell line, 4582 proenkephalin genes fibroblasts, 1525 regenerating, 3185 germ cell transcription, 3717 fms genes, 2703 Ltk- cells, 103, 113 transcription initiation sites, 3717 foreign gene, 1192 macrophage lineage switching, 2703 proto-oncogene regulation, 3185 c-fos regulation, 3185 major histocompatibility complex class PTFI c-fpslfes II elements and factors, 593 DNA-binding activity, 254 human, 2521 male germ cells, 3239 v-raf-v-myc, 3562 myeloid expression, 2521 mammary carcinogenesis ras, I gamma radiation, 405 preneoplastic event, 1593 c-Ki-ras, 1593 a- and 3-globin genes mammary epithelial cells, 4027 ras mutations, 405 differential expression, 3591 mature B cells and macrophages, 3562 H-ras oncoprotein expression in pancre- ,B-globin promoter mdri promoter atic 3-cells, 1779 transcription regulation, 972 cell-specific activity, 6036 recombination models, 103, 113 glucocorticoid receptor, 4574 cis-acting elements, 6036 repair of double-stranded breaks, 113 glycerol-3-phosphate dehydrogenase pro- mdrla promoter retinoic acid receptorly moter structural analysis, 3596 isoform, 2335 sequence conservation with human transcript heterogeneity, 35% retinoic acid-induced differentiation, 486 promoter, 5244 mdr gene family, 1652 ribosomal DNA promoter, 4970 structural organization, 5244 amplification, 1642 RNA polymerase I enhancers growth arrest-specific genes overexpression, 1642 ribosomal DNA, 4816 regulation, 1525 physical mapping, 1642 SAAI, 3619 growth factor-inducible gene, 3569 megakaryocytopoiesis SAA2, 3619 H-2KIt/w region, 138 cholinesterase gene expression, ma- SAA3, 3619 H19 gene product, 28 nipulation of, 6046 serum amyloid A3 gene hck gene modulation, 6046 C/EBP-binding sequences, 6624 promoter region, 4603 meiotic prophase, 1828 cell-specific expression, 6624 heat shock factor methylation patterns, 43% serum amyloid A gene DNA binding to heat shock element, N-methyl-N-nitrosourea, 1593 regulation, 3619 1600 Mov13 mutant embryos, development spermatogenic and somatic cells, 3717 transcriptional activation, 1600 of, 1452 surfeit locus hematopoietic progenitor cell multidrug resistance, 1652 CpG-rich islands and genes, 605 differentiation, 4846 multidrug resistance gene, 6036 T cells, 3663 granulocyte colony-stimulating factor, multidrug-resistant cells, 1642 T-cell maturation, 4266 4846 muscle, striated T-cell receptor P enhancer granulocyte-macrophage colony-stimu- mitochondrial DNA structure and DNA-binding proteins, 5027 lating factor receptor, 4846 expression, 5671 functional analysis, 5027 hemopoiesis, 4953 specialized subtypes, 5671 teratocarcinoma stem cells, 486 hepatocellular carcinomas c-myb transgene, 705 testis, 1828, 4294 chemically induced, 5728 N-myc allele, inactive Thy-I gene mdr3 overexpression, 5728 germ line transmission, 6755 DNA signal, 43% multidrug resistance gene overexpres- homologous recombination, generation transcriptional activator Krox-24, 3456 sion, 5728 by, 6755 transforming c-Ki-ras mutation, 1593 spontaneous, 5728 N-myc expression, 486 transgenic hepatoma cells, 3619 N-myc gene cardiac myocyte hyperplasia, 3709 hexamethylene bisacetamide, 3535 differential regulation, 2096 cytomegalovirus enhancer, 4406 high-frequency disruption, 1799 N-myc, 1799 diphtheria toxin A gene, 474 histidine-rich charge clusters, 138 c-myc proteins genetic ablation, 474 homologous recombination, 1799 translation and turnover, 3952 human erythropoietin gene expression, HSP86, 3239 c-myc regulation, 3185 930 immunoglobulin kappa alleles myogenic differentiation, 4948 mouse mammary tumor virus expres- recombination, 569 Na,K ATPase al gene sion, 5822 immunoglobulin kappa light-chain genes, genomic DNA sequences, functional c-myc, 3709 4314 expression, 6619 transmembrane protein, 138 immunoglobulin X2-chain gene overlapping genomic DNA segments, tumor necrosis factor i nuclear protein interaction, 5894 cotransfection, 6619 interleukin-2, 5865 palindromic sequence, 5894 neutron radiation, 405 limiting step, 5865 promoter, 5894 novel gene RNA processing, 5865 transcription, 5894 ecotropic retroviral receptor, closely VL30 activation, I int-i protein, 2723 related to, 3663 Zfx protein, 681 interleukin-6 gene, 4953 isolation, 3663 Zfy-2 protein, 681 xxx SUBJECT INDEX MOL. CELL. BIOL.

zinc finger domains, 418 stable, 2269 v-myb zona pellucida genes synthesis trans activation, 2285, 2591 developmental regulation, 1507 mammalian cells, 4529 transformation, 2591 Zp-2 T3 RNA polymerase, 4529 c-Myc oocyte-specific expression, 1507 trans-splicing, 1764, 1769 amino-terminal domain Mouse mammary tumor virus trimethylguanosine cap, 1764, 1769 neoplastic transformation, 5914 gene expression triosephosphate isomerase transcription activation, 5914 dexamethasone, 4211 penultimate exon, 5215 cAMP-regulated, 184 lipopolysaccharide, 4211 translation, 5215 cardiac myocyte hyperplasia, 3709 int-i promoter, 4170 unstable, 2269 Chinese hamster ovary cells transgenic mice X. Iaevis, 816 protein synthesis-dependent mRNA negative regulation, 5822 X. laevis embryos, 4123 increase, 5814 tissue-specific expression, 5822 MRP human, 184 Wnt-J promoter, 4170 mitochondrial RNA sequences leucine zipper M-phase promoting factor interaction, 2191 erythroleukemia differentiation inhibi- biosynthesis, 3847 site-specific cleavage, 2191 tion, 5333 cell cycle, 3847 Mul mRNA degradation human, 3847 AdhJ mutants poly(A) tail shortening, 6132 p34, 3847 polyadenylation, 2090 translation-dependent step, 6132 mrl splicing, 2090 osteosarcoma cells, 184 c-myc-regulated, 1265 maize transposable element, 2090 protein kinases A and C, 184 plasminogen activator inhibitor 1, 1265 ,uB RNA accumulation, 184 MRF4 immunoglobulin ,u heavy-chain enhancer transgenic mice, 3709 trans activation, 3934 regulation, 3145 c-myc gene mRNA mucAB HeLa cells 3'-end processing, 2599 BALB 3T3 cells chromosomal DNA replication initia- 5' untranslated region, 816 transformation, 5359 tion, 4899 association with nuclease activity, 2060 plasmid misrepair gene, enterobacterial, c-myc promoter C. elegans, 1764, 1769 5359 T-lymphocytic cell lines cyclic AMP analogs, 391 Mucor racemosus c-Myb, trans-activation by, 5747 decay, 2060, 2269 ras gene, human c-myc protein degradation dimorphic fungus, 6654 human c-myc, 6132 gene family, similarity, 6654 autosuppression, 4961 poly(A) tail shortening, 6132 Multidrug resistance gene ras cooperation, 4%1 translation-dependent step, 6132 mouse c-myc proteins down regulation by v-src, 3584 mdrl, 6036 murine erythroleukemia cells, 3952 enhancer of translational initiation, 3441 Murine cell lines translation and turnover, 3952 enzyme that adds poly(A), 846 nuclear factor I c-myc regulation F9 teratocarcinoma cells, 391 c-fos regulation, 3185 farnesyl pyrophosphate synthetase multiple forms, 1041 transcription initiation sites, 2315 Muscle, striated c-jun regulation, 3185 mammalian, 2060 mouse liver N-myc sense-antisense RNA duplexes, mitochondrial DNA structure and regenerating, 3185 4180 expression, 5671 mouse, 3185 nuclear transport of proteins, 1287 specialized subtypes, 5671 N-myc p60vsrc, 3584 Muscle-specific activity embryonic stem and pre-B cell lines, poly(A) polymerase, 846 skeletal troponin I promoter 1799 poly(A) tail, 3441 interaction between regulatory se- high-frequency disruption, 1799 enhancer of translational initiation, quences and elements, 3468 homologous recombination, 1799 3441 Muscle-specific promoter region inactive allele polyadenylation Duchenne muscular dystrophy gene, 193 germ line transmission, 6755 2' hydroxyl requirement, 1705 Mutagenesis homologous recombination, generation minimal substrates, 1705 p60c-src activation, 1307 by, 6755 pre-mRNA SH2- and SH3-coding domains, 1307 mouse embryonic stem cells, 6755 ordered splicing, 5591 site-directed mouse, 486, 1799 S phase of cell cycle, 5591 c-src, 1307 neural cell adhesion molecule thymidine kinase, 5591 mXBP/CRE-BP2 suppression, 2012 pre-mRNA splicing, 324, 4942 cyclic AMP response element, 1609 neuroblastoma cells PRP18, 324 c-Jun, 1609 human leukocyte antigen, 5416 quail neuroretina cells, 3584 12-O-tetradecanoylphorbol- 13-acetate somatic cell fusion, 5416 rat, 2315 rat retinoic acid receptor a, p, and -y response element, 1609 mRNAs, 391 myb neuroblastoma, 2012 ribosomal protein S19, 816 REBI resemblance, 5226 regulation RNA modification-exclusion technique, c-Myb adenovirus vector, 6700 4942 T-lymphocytic cell lines posttranscriptional control, 6700 RNA processing, 2599 c-myc promoter trans-activation, 5747 retinoic acid-induced differentiation, 486 S. cerevisiae, 324, 2269, 2599 c-myb RNA sense-antisense RNA duplexes, 4180 mitochondrial translation, 4590 alternative splicing, 2715 teratocarcinoma stem cells, 486 ribosomal protein interaction, 4590 human, 2715 N-myc excision translational activator, 4590 c-myb transgene chromosome 2, 823 SP6 plasmid-generated, 1287 mouse erythroleukemia cell human, 823 stability of maternal mRNAs, 4123 differentiation, 705 neuroblastoma cells, 823 VOL. 10, 1990 SUBJECT INDEX xxxi

N-myc gene neu gene NF-KB-like factor chicken, 2017 rat, 3247, 6306 activation, 3818 differential regulation, 2096 regulation human fibroblasts, 3818 expression, 2017 cis- and trans-acting elements, 6306 interleukin-6 induction, 3818 mouse, 2096 transformation, 3247 NFKB-like hepatoma nuclear factor organization, 2017 Neural cell adhesion molecule interleukin-1, 6283 Myeloid leukemia 5' region mouse factor B gene enhancement, 6283 Evi-2 integration site, 4658 structural region, 3314 NF-KB-like transcription factor mouse, 4658 transcription initiation sites, 3314 interleukin-6 gene activation, 561 MyoD1 N-myc, 2012 lymphokines somite formation in early Xenopus promoter, 1959 inflammatory, 561 embryogenesis, 1516 rat, 3314 NGFI-B protein trans activation, 3934 rat neuroblastoma, 2012 thyroid/steroid receptor family Xenopus genes with homology to, 1516 regulatory elements, 1959 posttranslational modification, rapid, Myogenic differentiation suppression, 2012 6454 colony-stimulating factor gene expres- Neuroblastoma cells Nicotiana tabacum sion, 4948 chromosome 2, 823 recombination Myogenin human, 361, 823 homologous, 492 trans activation, 3934 nerve growth factor, 5015 intermolecular, 492 Myosin nerve growth factor receptor cDNA NIH 3T3 cells cis regulation, 2133 transfection, 5015 c-fos promoter plasmids human, 1095 neuronal differentiation, induction of, transcriptional activity, altered, 6073 isoform evolution and function, 1095 5015 Moloney murine leukemia virus light chains Isa and 3nm, 1095 human leukocyte antigen expression, chimeric tRNA-driven antisense tran- light-chain 1/3 gene 5416 scripts, 6512 alternative splicing, 2133 N-myc excision, 823 resistance, 6512 Myosin light-chain gene N-myc expression, 5416 v-raf transformed, 6073 chicken embryo, 2562 pp60src kinase activation, 361 Ha-ras L23, 2562 somatic cell fusion, 5416 mitogenic signal transduction, 5314 regulation, 2562 Neuronal differentiation mutation, dominant inhibitory, 5314 Myristylation inhibition, 5324 serum stimulation, 0, TO p56Ick activation, 5197 PC12 cells, 5324 lipid production, induction of, 6683 Ha-ras, 5324 NIH 3T3 cells transformed with c-H-ras N glycosylation Neuroretina cells recessive (mediator-) revertants, 1822 S. cerevisiae mRNAs NIH 3T3 fibroblasts dolichol phosphate mannose synthase, down regulation by v-src, 3584 phospholipase C--y overexpression 5796 p60v-src, 3584 basic fibroblast growth factor, 6069 Na,K ATPase al gene quail embryos, 3584 phosphatidylinositol hydrolysis, 6069 mouse Neurospora crassa platelet-derived growth factor, 6069 genomic DNA sequences, functional acetate utilization, 2638 nit-2 expression, 6619 N. crassa, 1056 overlapping genomic DNA segments, al-I 1-Nitrosopyrene cotransfection, 6619 carotenoid biosynthetic gene, 5064 intrachromosomal homologous recombi- Na,K-ATPase a2 isoform cloning, 5064 nation in human cells, 3945 ouabain-resistant mutants, 1367 photoregulation, 5064 nt' rat, 1367 sequence, 5064 glucocorticoid receptor Negative element duplication-induced mutation of a new amino-terminal transcriptional modula- vimentin gene expression, 2349 gene, 2638 tory domain, 4574 Neoplastic transformation nit-2, 1056 nuc-lJ human, 464 nuc-l + N. crassa human T-lymphotropic virus type I, 413 molecular analysis, 5839 molecular analysis, 5839 insulinlike growth factor I receptor over- phosphorus acquisition, 5839 phosphorus acquisition, 5839 expression, 464 scon-2 negative regulatory gene, 5207 Nuclear factor I c-Myc amino-terminal domain, 5914 Newcastle disease virus human cell lines, 1041 ras oncogene, 413 hemagglutinin-neuraminidase glycopro- multiple forms, 1041 rat embryo fibroblasts, 413 tein, 449 murine cell lines, 1041 tax gene, 413 NF-I gene Nuclear factors transcription activation, 5914 promoter transcription, 387 binding to cAMP regulatory element, Nerve growth factor rat, 387 3357 basic fibroblast growth factor, 1556 NF-El phosphoenolpyruvate carboxykinase c-fos induction, 1556 4-globin promoter gene, 3357 Nuclear phosphoprotein SSN6 G.-a RNA, 3277 protein-DNA interactions, 282 S. cerevisiae human human, 282 functional domain, 4744 nerve growth factor receptor cDNA Spl displacement, 282 N-terminal TPR, 4744 transfection, 5015 NF-KB Nuclear protein neuroblastoma cells, 5015 activation, 422 S. cerevisiae neuronal differentiation, induction of, granulocyte-macrophage colony-stimulat- SPT6 gene, 4935 5015 ing factor gene, 1281 transcription, 4935 PC12 cell line, 1556 interleukin-6 gene expression Nuclear proteins pheochromocytoma cells, 3277 activation, 2327 T-cell receptor a gene regulation, 4720 N-ras, 1556 pre-B cells, 422 T-cell specific regulation, 3277 transcriptional activator, 1281 enhancer elements, hypomethylated, xxxii SUBJECT INDEX MOL. CELL. BIOL.

interaction, 4720 Oenothera berteriana p53 Nuclear transport cytochrome b locus Friend virus-induced erythroleukemia, proteins RNA editing, 2428 3307 SP6 plasmid-generated mRNAs, 1287 Onchocerca volvulus inactivation, 3307 S. cerevisiae nucleus, 353 C. elegans mouse T7 RNA polymerase spliced leader sequence, 2765 phosphorylation, 6472 signal-mediated import, 353 transcribed regions, 2765 osteosarcomas target gene transcription, 353 Oncogene action cell cycle control, 5772 Nuclease activity human thyroid epithelial cells p53 protein mRNA immortalization, conditional, 5365 nuclear accumulation decay, 2060 Oncogene target nuclear localization signals, 6565 mammalian, 2060 pp85, 2909 tumorigenesis, 6565 Nuclei Oncostatin M p53 tumor suppressor gene pre-mRNA processing C-terminal domain, 1882 human factors involved in, distribution of, growth-inhibitory activity, 1882 mutations, 5502 3524 Opal suppressor pS6lck activation S. cerevisiae nuclei, 3524 construction autophosphorylation, 5197 S. pombe nuclei, 3524 oligonucleotide-directed mutagenesis, myristylation, 5197 small nuclear ribonucleic acids, 3524 4379 regulatory carboxy-terminal tyrosine, Nucleolar antigen S. cerevisiae, 4379 5197 human, 3253 tRNATrIp gene, 4379 p59fyfn p120, 3253 Origin control sequences phosphatidylinositol-3 kinase Nucleolin amplification, 2070 thrombin-dependent association, 3806 p34cdc2 protein kinase, 3607 ribosomal DNA replicons, 2070 p60c-src phosphorylation, 3607 T. thermophila, 2070 activation of proto-oncogene Nucleosome assembly Ornithine decarboxylase point mutations in SH2, 2855 chromatin assembly, 2863 Chinese hamster ovary cells phosphatidylinositol-3 kinase simian virus 40 DNA, 2863 protein synthesis-dependent mRNA thrombin-dependent association, 3806 Nucleosome depletion increase, 5814 p60c-src activation S. cerevisiae Ornithine decarboxylase gene SH2- and SH3-coding domains, 1307 centromeres, 5721 expression regulation c-src chromatin structure, 5721 cell type specific, 5525 site-directed mutagenesis, 1307 Nucleosome-positioning sequence growth stimulation, 5525 p60v-src GCN4 activation, 4256 Ornithine transcarbamylase gene glycoprotein, 830 Nucleosomes hepatoma cells, 1180 major potential substrate, 830 a2 rat, 1180 mRNAs repressor, 2247 regulatory elements, 1180 down regulation by v-src, 3584 S. cerevisiae, 2247 Osteoblasts plasma membrane matrix, 830 TRPl/ARSI chromatin, 2247 transforming growth factor 03, 4473 quail neuroretina cells, 3584 Nucleotide excision repair Osteosarcoma cells p120 human cells, 3945 cAMP-regulated c-myc expression, 184 human nucleolar antigen, 3253 intrachromosomal homologous recombi- human, 184 p180 nation c-myc RNA accumulation, 184 novel recycling transmembrane glyco- l-nitrosopyrene, 3945 platelet-derived growth factor, 184 protein, 2606 UV, 3945 protein kinases A and C, 184 P450scc gene Osteosarcomas human O mannosylation p53 12-O-tetradecanoylphorbol- 13-acetate, S. cerevisiae cell cycle control, 5772 repression by, 6013 dolichol phosphate mannose synthase, OTF2 A23187, repression by, 6013 57% immunoglobulin heavy-chain promoter cis elements, independent, 6013 Oct- I transcription, 2145 cyclic AMP, induction by, 6013 herpes simplex virus type I transactiva- oxidant stress Pancreatic P-cells tor Vmw65, 4974 heme oxidase gene, human, 4967 diabetes induction in male transgenic protein-DNA complex assembly, 4974 mice, 1779 Oct-2 p34 insulin gene transcription factor, 1564 interleukin-2 gene promoter activation, human, 3847 H-ras oncoprotein expression, 1779 5464 M-phase promoting factor, 3847 Pancreatic islet cells Octamer-binding protein p34cdc2 protein kinase rat hemopoietic cells, 1293 activation cyclic AMP-responsive element, 6799 immunoglobulin gene transcription, 982 Ha-rasva l2Thr59 310 glucagon gene activation, 6799 Octamer-binding transcription factor I S6 kinase activation, 310 Pancreatic mRNA synthesis immunoglobulin promoter transcription Xenopus oocytes, 310 mouse, 254 B-cell-specific component require- nucleolin, phosphorylation of, 3607 PTFI ment, 6204 p36 DNA-binding activity, 254 octamer-containing promoter activation, enhanced expression, 3216 Paramecium tetraurelia 6204 human surface antigen gene expression Octamer-binding transcription factor 2 hepatocellular carcinoma, 3216 multilevel regulation, 1538 immunoglobulin promoter transcription p38 Parasites B-cell-specific component require- glucagon, 2468 stable transfection of L. major, 1084 ment, 6204 p21 ras, 2468 parp genes octamer-containing promoter activation, phosphorylation, 2468 T. brucei, 3036 6204 rat liver cells, 2468 transcription, 3036 VOL. 10, 1990 SUBJECT INDEX xxxiii

PC12 cell line Phosphatidylinositide metabolism NIH 3T3 fibroblasts, 6069 basic fibroblast growth factor, 1556 ras-induced Xenopus oocyte maturation, platelet-derived growth factor c-fos induction, 1556 923 receptor signaling complex, 2359 nerve growth factor, 1556 Phosphatidylinositol-3 kinase tyrosine kinase, 4770 N-ras, 1556 human platelets, 3806 tyrosine kinase activity, 435 PC12 cells thrombin-dependent association Phospholipase C-type reaction growth factor-inducible protein, 6769 p59&fl, 3806 inhibitor Pip92, 6769 p60c-src, 3806 c-fos transcription inhibition, 5553 Ha-ras Phosphatidylinositol hydrolysis serum response factor phosphoryla- mutation, dominant inhibitory, 5324 NIH 3T3 fibroblasts, 6069 tion, 5553 neuronal differentiation, 5324 phospholipase C-y overexpression, 6069 Phosphorus acquisition PC12 pheochromocytoma cell nuclei Phosphatidylinositol kinase N. crassa lactate dehydrogenase, 770 colony-stimulating factor-1 receptor, nuc-l +, 5839 phosphotyrosine, 770 5601 Phosphorylation PCNA regulation GAP-associated proteins, 5601 ETS-2 protein human, 303 GTPase-activating protein, 5601 regulation, 1249 introns, 303 Phosphatidylinositol kinase type I activity T-cell antigen receptor-CD3 complex, Pea chicken embryo fibroblast cells, 3280 1249 rbcS-3A pp60c-src GAL4, 4623 phytochrome-responsive element, 5565 human, 3280 hsp28, 1276 upstream region, 5565 mutant forms, 3280 nucleolin, 3607 PEA3 and PEAl sites Phosphodiesterase gene p34cdc2 protein kinase, 3607 polyomavirus DNA replication, 4996 D. discoideum, 1921 p38 Pea leaf development structure, 1921 glucagon- and ras-enhanced, 2468 rRNA gene activity, 842 Phosphoenolpyruvate carboxykinase rat liver cells, 2468 PETJ22 locus binding of nuclear factors to cAMP regu- Phosphotyrosine divergent overlapping transcripts, 3027 latory element, 3357 lactate dehydrogenase, 770 S. cerevisiae, 3027 chimeric genes PC12 pheochromocytoma cell nuclei, PGA4 regulation, 2660 770 binding to S. cerevisiae GAL4-binding enhancer upstream of gene, 3770 Phosphotyrosyl protein sites, 1432 extinction of gene expression 42-kilodalton protein, 3020 S. cerevisiae GAL4-binding sites, 1432 chromatin-binding protein, 3782 S. cerevisiae S. pombe, 1432 phosphorylation, 3357 protein-tyrosine kinase activity, 6244 P-glycoprotein promoter, 2418 YPKI gene product, 6244 mdrla promoter elements, 480 serine(threonine) protein kinase, 3020 structural analysis, 3596 rat, 3770 PHRI transcript heterogeneity, 3596 rat liver DNA damage, induction of expression, murine J774.2 cells, 3596 nuclear factors, 2418 4630 Pheochromocytoma 12 cells rat liver extracts, 480 S. cerevisiae, 4630 Gs-a RNA, 3277 transcription regulation, 480 Physarum polycephalum nerve growth factor regulation, 3277 transcription, regulation of intron-encoded endonuclease Pheochromocytoma cells cyclic AMP-dependent, 3357 lactate dehydrogenase, 770 TSE1, 2660 group I intron, homing of, 3386 nuclei, 770 Phosphoenolpyruvate carboxykinase gene I-Ppo, 3386 PC12, 770 glucocorticoid response unit, 4712 ribosomal DNA, 3386 phosphotyrosine, 770 transcriptional regulation Phytochrome-responsive element Pheromone response element CCAAT/enhancer-binding protein, rbcS-3A S. cerevisiae 6264 pea, 5565 PQ box, 6809 Phosphoglucomutase Pim-l Pheromone response pathway isozyme gene, 1415 human hemato-lymphoid cell lines, 1680 Ga, 2582 S. cerevisiae, 1415 selective transcription of, 1680 hybrid mammalian-yeast Ga proteins, transcription Pip92 2582 galactose inducible, 1415 BALB/c 3T3 cells, 6769 S. cerevisiae, 2582 glucose repressible, 1415 growth factor-inducible protein, 6769 signal transduction pathway, 2582 Phosphoinositide pathway agonists PC12 cells, 6769 PHO4 costimulation, molecular basis of, 6325 Pituitary phosphatase regulon interleukin-1, synergy with, 6325 human transcriptional control, 2224 interleukin-2 gene induction, 6325 prolactin gene expression, 4690 S. cerevisiae, 2224 Phosphoinositide signaling pathways Plasma membrane matrix Phorbol ester G-protein coupling, 3117 glycoprotein, 830 ribonuclease system regulation, 5983 oncogenes, 3117 transformed cells, 3117 p60Vsrc 830 Phosphatase Phospholipase C Plasmid S. cerevisiae, 1049 chromosomal localization, 720 high-copy-number tRNA splicing, 1049 developmental regulation, 720 proteolipid gene, 3397 Phosphatase regulon genomic organization, 720 S. cerevisiae, 3397 PHO4, 2224 T. brucei, 720 trifluoperazine resistance, 3397 positive regulatory protein, 2224 Phospholipase C-y Plasmid repair and recombination S. cerevisiae, 2224 epidermal growth factor receptor X. laevis oocytes transcriptional control, 2224 association, 435 X-irradiated plasmids, 5849 Phosphatidylcholine metabolism fibroblast growth factor, acidic, 4770 Plasmid-chromosome recombination diacylglycerol production, 333 heparin-binding growth factor 1, 4770 African green monkey kidney cells, 37 X. Iaevis oocytes, 333 overexpression radiation enhancement, 37 xxxiv SUBJECT INDEX MOL. CELL. BIOL.

Plasminogen activator inhibitor I Polyadenylation activation, 3204 mrl heterogeneous nuclear ribonucleoprotein phosphorylation, 3204 c-myc-regulated, 1265 C protein-RNA cross-linking, 6397 X. Iaevis, 3204 Plasmodium berghei maturation specific Xenopus S6 kinase II, 2413 chromosome cytoplasmic elements, 5634 PPRl protein size polymorphism, 6759 poly(A) tail size diversity, 5634 S. cerevisiae telomeres, long insertions within, 6759 stable complexes, 5634 C6 zinc finger, 5128 organization, 2423 mRNA DNA-binding specificity and affinity, subtelomeric repeats, 2423 2' hydroxyl requirement, 1705 5128 Plasmodium falciparum minimal substrates, 1705 PQ box A and T homopolymeric stretches, 3243 uridylate tract substitution, 6397 S. cerevisiae DNA inversion, 3243 Polyadenylation substrates pheromone response element, 6809 Plasmodium yoelii 64-kilodalton protein, 1244 Pre-18S rRNA extrachromosomal DNA cross-linking, 1244 processing in vitro, 3868 complex transcription, 6381 Polyadenylation-specific complexes Pre-B cells mitochondrial functions, 6381 poly(A) tail polymerization, 295 Abelson murine leukemia virus, 569 Plastin Poly(A)-binding proteins immunoglobulin kappa alleles calcium-binding domain, potential, 1818 S. purpuratus, 3994 recombination, 569 human, 1818 Polymerase basic protein 1 lipopolysaccharide-unresponsive mutant, isoforms, 1818 AIWSN/33 influenza virus, 4139 422 N-terminal sequences, 1818 nuclear localization, 4139 mouse, 569 polymerase chain reaction, anchored, ,-Polymerase NF-KB activation, 422 1818 human, 3852 Pre-mRNA Platelet-derived growth factor promoter prolactin A-chain transcripts ras-responsive element, 3852 N6-methyladenosine, 4456 alternative splicing, 6051 Polyomavirus thymidine kinase normal cellular proteins, 6051 DNA replication ordered splicing, 5591 tumor specificity, 6051 PEA3 and PEAI site synergy, 4996 S phase of cell cycle, 5591 a-receptor gene subenhancer requirements, 4996 Pre-mRNA processing retinoic acid, 6781 enhancer and promoter elements factors involved in, distribution of, 3524 transcription promotion, 6781 substitution for an upstream activation S. cerevisiae, 3524 ,-receptor sequence in S. cerevisiae, 947 S. pombe, 3524 kinase insert sequence deletion, 801 middle-T antigen-tyrosine kinase com- Pre-mRNA splicing, 4942 B-protein domain plex Preproendothelin- 1 promoter conformational changes, 5496 cellular components, 5569 endothelial cells, 4854 receptor interaction, 5496 stoichiometry, 5569 GATA-binding protein, nonerythroid, transforming activity, 5496 viral components, 5569 4854 cAMP, 184 Polypeptide binding human, 4854 human, 184 Drosophila hsp7O promoter, 4233 Pre-rRNA c-myc RNA accumulation, 184 UV cross-linking, 4233 D. melanogaster, 4667 NIH 3T3 fibroblasts Polysome processing basic fibroblast growth factor, 6069 immunoglobulin a heavy-chain RNA, first event, 4920 phosphatidylinositol hydrolysis, 6069 382 large complex, 4920 phospholipase C--y overexpression, Porphobilinogen deaminase gene Primate 6069 erythroid-specific transcription factor, U2 small nuclear RNA osteosarcoma cells, 184 3838 evolution, 5876 phospholipase C-y, 2359 human, 3838 gene amplification, 5876 protein kinases A and C, 184 synergy between NF-El and CACCC multigene family, 5876 receptor kinase activity, 801 factor, 3838 natural selection, 5876 receptor signaling complex, 2359 Postinitiation transcriptional control structure, 5876 signal transduction, 801 D. melanogaster, 6041 Primate cells v-sis, 5496 pp60c-src DNA-binding protein Poliovirus chicken embryo fibroblast cells, 3280 damage-specific, 2041 HeLa cell infection human, 3280 UV-irradiated, 2041 TFIIIC modification, 5106 mutant forms, 3280 Priming Poliovirus receptor-related proteins phosphatidylinositol kinase type I beta interferon promoter activity, 854 human cells and tissues activity, 3280 human, 854 heterogeneous expression, 5700 pp6Osrc Prion proteins Poly(A) polymerase, 846 kinase activation hamster, 1153 Poly(A)+ RNA human, 361 scrapie, 1153 mouse neuroblastoma cells, 361 Procyclic acidic repetitive protein transcriptional machinery, reprogram- pp60v-src a-amanitin-resistant transcription unit, ming of, 6055 epidermal growth factor receptor 3492 X. laevis oocytes, 6055 biosynthesis, 1254 promoter analysis, 3492 Poly(A) tail pp85 T. brucei, 3492 enhancer of translational initiation, 3441 growth factor receptor target, 2909 Procyclic acidic repetitive protein genes maturation-specific polyadenylation, oncogene target, 2909 parp genes, 3036 5634 pp9orsk T. brucei, 3036 mRNA, 3441 chicken embryo fibroblasts, 2413 transcription, 3036 c-myc mRNA degradation, 6132 regulation in somatic cells, 3204 Proenkephalin size diversity, 5634 ribosomal protein S6 kinase germ cell transcription, 3717 Poly(A) tail polymerization mitogen-responsive, 2413 mouse cells, spermatogenic and somatic, polyadenylation-specific complexes, 295 S6 protein kinase II homologs 3717 VOL. 10, 1990 SUBJECT INDEX xxxv

rat cells, spermatogenic and somatic, stromelysin mRNA, 4284 Proto-oncogene regulation 3717 HT29 colon cancer cells c-fos regulation, 3185 transcription initiation sites, 3717 growth inhibition, 4650 c-jun regulation, 3185 Proenkephalin A overexpression, 4650 liver mesenchymal ontogeny, 736 tumor suppression, 4650 regenerating, 3185 rat, 736 interleukin-l mouse, 3185 Progesterone gene expression, 2731 c-myc regulation, 3185 a-fetoprotein gene promoter repression, induction, 2731 Protozoan 5002 signal transduction, 2731 T. brucei antihormones, 5002 neuronal differentiation, 2983 flagellar pocket protein, 4506 chimeric receptors, 5002 N-ras, 2983 PRP4 protein Progression phenotype regulation, 2983 S. cerevisiae, 1217 adenovirus type 5, 2027 Protein kinase, cyclic AMP dependent U4 small nuclear RNA, 1217 rat embryo, 2027 catalytic subunit PRP6 suppression, 2027 Aplysia spermatozoa, relative in, 6775 S. cerevisiae Prolactin Protein kinase, DNA activated PRP9, 6417 pre-mRNA HeLa cell nuclei, 6460 U4/U6 small nuclear ribonucleoprotein N6-methyladenosine, 4456 human particle protein, 6417 Prolactin gene human Ku autoantigen phosphoryla- PRP9 calcium regulation, 442 tion, 6472 S. cerevisiae human mouse p53 phosphorylation, 6472 PRP9, 6417 expression, 4690 simian virus 40 T antigen phosphoryla- U2 small nuclear ribonucleoprotein pituitary, 4690 tion, 6472 particle binding, 6417 regulatory elements, 4690 Protein kinases A and C PRP18 rat, 442 cAMP-regulated c-myc expression, 184 184 S. cerevisiae, 324 Prolactin induction human, splicing, 324 interferon-regulatory factor 1, 3087 c-myc RNA accumulation, 184 Proliferating cell nuclear antigen gene osteosarcoma cells, 184 Pseudogenes binding of homeodomain proteins, 872 Protein localization cDNA genes, 68 cyclin gene, 872 diversity, 3163 retroviral vector particles, 68 D. melanogaster, 872 efficiency, 3163 PTFI expression during development, 872 random signal sequences, 3163 DNA-binding activity, 254 growth regulation, 303 Protein sorting mouse, 254 human, 303 H+-ATPase pancreatic mRNA synthesis, 254 introns, 303 genetic analysis, 3737 PVT regulation S. cerevisiae vacuolar network, 3737 transcription, effects of translocations posttranscriptional, 3289 vacuolar acidification, 3737 on, 1835 transcriptional, 3289 Protein-binding domains translocation, 1835 structure, 872 yeast, Drosophila, and mammalian pro- Promoter teins Quail hck gene, 4603 T. brucei trypanosome leucine repeat mRNAs Promoter elements gene, 6436 down regulation by v-src, 3584 a-actin gene, 528 Protein-tyrosine kinase neuroretina cells, 3584 cis-acting, 528 epithelial cell receptor 3584 Promoter region analysis eck, cDNA cloning and characteriza- p60v_src Duchenne muscular dystrophy gene, 193 tion, 6316 Prostaglandin E2 ephlelk family, 6316 radl inositol 1,4,5-triphosphate, 57 S. cerevisiae analysis, 3750 MDCK cells, 57 YPKI gene product, 6244 cloning, 3750 ao-Protease inhibitor genes Protein-tyrosine kinase genes RADIO, 2485 cis-acting elements, 2625 D. discoideum, 3578 S. cerevisiae, 2485 mouse, 2625 developmentally regulated, 3578 S. pombe, 3750 negative and positive control, 2625 Protein-tyrosine phosphorylation RAD2 Protein kinase angiotensin II regulation, 3256 binding of nuclear factors to cAMP regu- calcium dependence, 6290 S. cerevisiae, 3256 latory element, 3357 Proteolipid gene RAD6 cAMP-dependent, 3824 high-copy-number plasmid, 3397 retrotransposition, 1017 cyclic AMP dependent S. cerevisiae, 3397 S. cerevisiae, 1017 reduced activity, 4518 trifluoperazine resistance, 3397 Ty transposition, 1017 cyclic AMP-dependent, 3357 Proton-translocating ATPase ubiquitin-conjugating enzyme, 1017 interleukin-l genetic analysis, 3737 RAD9 signal transduction pathway, 3824 S. cerevisiae vacuolar network, 3737 acidification S. cerevisiae mak, 2261 vacuolar 6554 mammalian, 2261 role in protein sorting and zymogen characterization, phosphoenolpyruvate carboxykinase activation, 3737 posttranslational action in cell cycle regulation of transcription, 3357 Proto-oncogene arrest after DNA damage, 6554 serine(threonine), 3020 K-fgf RADIO testicular germ cells, 2261 expression, 2475 RADI, 2485 tyrosine-phosphorylated, 3020 regulatory elements, 2475 S. cerevisiae, 2485 Protein kinase C c-kit rad mutants 3T3-TNR9 cells, 2122 ligand-dependent transforming poten- S. cerevisiae down regulation, 2122 tial, 6064 G2 arrest, 4678 epidermal growth factor stimulation receptor functions, 6064 UV damage repair, 4678 xxxvi SUBJECT INDEX MOL. CELL. BIOL.

Radiation induction of gene expression creatine kinase gene, brain gamma, 405 double-stranded RNA, 4424 cis-acting regulatory elements, 6533 mouse, 405 interferon, 4424 promoter region, 6533 neutron, 405 malignant transformation of rat embryo CYP2EI gene ras mutations, 405 fibroblasts, 4370 transcriptional control, 4495 Radiation-enhanced recombination transformed phenotypes cytochrome P-450d African green monkey kidney cells, 37 antisense-fos RNA, 1545 aryl hydrocarbon induction, 6765 c-raf-l partial reversion, 1545 increased precursor RNA processing, minimal transforming sequence c-Ki-ras 6765 definition, 2503 N-methyl-N-nitrosourea, 1593 DNA-mediated gene transfer, 689 mutational activation, 2503 mouse mammary carcinogenesis embryo Raf-J promoter region preneoplastic event, 1593 adenovirus type 5, 2027 human, 3325 Ha-ras progression phenotype, suppression, molecular organization, 3325 mitogenic signal transduction 2027 raf proteins inhibition, 5314 embryo fibroblasts, malignant transfor- DNA synthesis, induction of, 3828 mutation, dominant inhibitory, 5314 mation of transformation, induction of, 3828 NIH 3T3 cells, 5314 BCL2, 4370 v-raf neuronal differentiation C-HA-RAS, 4370 NIH 3T3 cells, transformed inhibition, 5324 epidermal growth factor receptor c-fos promoter plasmids, 6073 mutation, dominant inhibitory, 5324 truncated, secreted form, 2973 v-raf-v-myc PC12 cells, 5324 farnesyl pyrophosphate synthetase mature B cells and macrophages, 3562 K-ras mRNA, 2315 murine bone marrow cells, transforma- activation, 405 transcription initiation sites, 2315 tion of, 3562 neutron radiation, 405 fibroblasts, 4284 Random signal sequences ras mutations, 405 v-fos transformed, 5626 protein localization, 3163 ras mutations suppression of transformation, domi- raplA/Krev-l gamma radiation, 405 nant, 5626 human, 2901 neutron radiation, 405 gene transfer raplA regulation K-ras, 405 retroviral vectors, 3268 GTPase-activating proteins, 2901 N-ras glucagon, 2468 RAR-a basic fibroblast growth factor, 1556 glucagon gene HL-60 myeloid leukemia cells, 2154 c-fos induction, 1556 cyclic AMP-responsive element in retinoic acid nerve growth factor, 1556 pancreatic islet cells, 6799 induction of granulocytic differentia- neuronal differentiation, 2983 transcriptional activation, 6799 tion, 2154 PC12 cell line, 1556 growth hormone gene ras protein kinase C activity promoter, 5378 glucagon, 2468 regulation, 2983 Z-DNA, 5378 human H-ras oncoprotein haptoglobin gene M. racemosus gene family, similarity, diabetes induction in male transgenic interleukin-1 and interleukin-6 re- 6654 mice, 1779 sponse elements, 5967 IRA2, 4303 human interleukin-6- and dexamethasone- mammalian pancreatic p-cells, 1779 responsive element, 1573 prenylation, 5945 c-ras p21s hepatitis B virus enhancer, 4427 X. laevis oocytes, 5945 smg-211rapllKrev-1 proteins hepatocytes in primary culture, 689 mouse, I subcellular distribution, 2645 hepatoma cells, 1180, 5967 c-myc protein, human tissue distribution, 2645 histone gene cooperation, 4961 ras proteins regulatory elements, 585 negative regulator of, 4303 cyclic AMP phosphodiesterase stimula- testis-specific H2B (TH2B), 585 nuclear target, I tion, 1689 human T-lymphotropic virus type I, 413 p21, 2468 hormone-induced maturation, 1689 hypoxanthine-guanine phosphoribosyl- p38 transforming, 1689 transferase gene enhanced phosphorylation, 2468 Xenopus oocytes, 1689 cis-acting elements, 4356 rat liver cells, 2468 ras-induced maturation a,-inhibitor III gene S. cerevisiae, 4303 phosphatidylinositide metabolism, 923 cis-acting regulatory elements, 3483 transformation, I Xenopus oocytes, 923 hepatic transcription, 3483 VL30 transcriptional element activity, I ras-like genes insulin II gene, 1784 rasl human teratocarcinoma cell line, 1793 liver, 4427 byri, 549 ras-responsive element liver cells, 2468 mating-type genes human, 3852 liver extracts, 480 starvation-induced transcription, 549 P-polymerase promoter, 3852 liver nuclear factors, 2418 S. pombe, 549 Rat mesenchymal ontogeny, 736 c-H-ras al-acid glycoprotein gene N-myc, 2012 recessive (mediator-) revertants, 1822 cytokine response element, 3965 myoblasts, 3268 transformation of NIH 3T3 cells, 1822 a platelet-derived growth factor receptor myotubes, 3268 c-Ha-ras characterization, 2237 Na,K-ATPase a2 isoform albumin gene, 1461 isolation, 2237 ouabain-resistant mutants, 1367 a-fetoprotein gene, 1461 angiotensinogen gene neoplastic transformation, 413 down regulation, 1461 acute-phase response element, 1023 neu gene, 3247 human binding of two proteins, 1023 cis- and trans-acting elements, 6306 intr, 0, 4990 angiotensinogen gene transcription regulation, 6306 transcriptional readthrough block, glucocorticoids, role of, 4389 neural cell adhesion molecule 4990 interleukin-I stimulation, 4389 suppression, 2012 human hepatoma cells, 1461 C/EBP, 4427 neural cell adhesion molecule gene, 5' VOL. 10, 1990 SUBJECT INDEX xxxvii

region human B cells, 3690 Retinoic acid receptor, alpha structural organization, 3314 immunoglobulin D switching, 3690 dominant negative mutation, 6445 transcription initiation sites, 3314 human cells, 3945 embryonal carcinoma cell neuroblastoma, 2012 intermolecular, 492 retinoic acid nonresponsive, 6445 NF-I promoter transcription, 387 intrachromosomal homologous Retrogene olfactory epithelium, 2237 1-nitrosopyrene, 3945 integrated, 1891 ornithine transcarbamylase gene nucleotide excision repair, 3945 structure, 1891 regulatory elements, 1180 UV, 3945 Retrotransposable element p21 ras, 2468 N. tabacum, 492 Anopheles gambiae, 863 P-450c gene plasmid-chromosome, 37 mosquito, 863 cis-acting DNA element, 1470 radiation enhancement, 37 Retrotransposition phosphoenolpyruvate carboxykinase Recombination models RAD6, 1017 gene, 480 Ltk- cells, 113 S. cerevisiae, 1017 upstream enhancer, 3770 mouse, 113 Ty transposition, 1017 phosphoenolpyruvate carboxykinase nonconservative intermolecular Retrotransposon promoter, 2418 Ltk- cells, 103 baculovirus genome phosphorylation, 2468 repair of double-stranded breaks, 113 integration, 3067 proenkephalin A, 736 Recombination, homologous C. fasciculata, 615 proenkephalin genes mammalian cells, 4837 miniexon gene locus, 615 germ cell transcription, 3717 transcription, stimulation by, 4837 rapidly rearranging, 615 transcription initiation sites, 3717 Regulatory elements S. cerevisiae, 2882 prolactin gene actin SC proximal promoter, 206 S. pombe calcium regulation, 442 D. melanogaster, 206 two related families, 6791 ras oncogene, 413 Regulatory proteins T. ni, 3067 ribosomal DNA genomic footprinting, 2554 TED factors directing transcription, 3105 human gene organization, 3067 ribosomal gene transcription normal tissues, 2554 transcription, 3067 promoter element, enhancer and core, interferon a-i gene, 2554 Ty 5177 c-rel multimeric arrays, 2882 stimulating factor, 5177 promoter insertion, 4788 Retroviral RNA splicing control RNA polymerase I transcription factors, c-rel protein suboptimal processing signals, 696 3105 mouse Retroviral vector particles rUBF C-terminal transcriptional transactiva- cDNA gene formation, 68 DNase footprints, 3810 tion domain, 5473 pseudogenes, 68 sequence element cooperativity, 1784 N-terminal regulatory domain, 5473 Retrovirus Spl recognition site, 387 Repair adenovirus membrane-associated protein spermatogenic and somatic cells, 3717 double-stranded DNA breaks in mouse epidermal growth factor receptor stromelysin mRNA Ltk- cells, 113 down regulation, 5521 epidermal growth factor stimulation, Repressor protein binding site gene transfer, 5521 4284 CAR1, 3884 avian, 3095 tax gene, 413 S. cerevisiae, 3884 chicken embryo fibroblast cells testis Retinoblastoma gene product transformation, 3095 glutamic acid decarboxylase expres- hyperphosphorylation fyn gene sion, 4701 simian virus 40 large-T-antigen-binding human, 3095 tissue specificity, 1784 domains, 6586 Retrovirus vectors transcription regulation, 480 Retinoblastoma susceptibility gene product gene transfer, 4239 transformation, 3247 minimal T- and ElA-binding domain, infection, 4239 transforming growth factor alpha gene 3761 RGR1 characterization, 2111 simian virus 40, 3761 S. cerevisiae promoter sequences, 2111 Retinoic acid glucose repression, 4130 tyrosine aminotransferase gene chronic granulomatous disease, autoso- [rho-] chromatin structures, 3334 mal mitochondrial DNA, 10 cis-acting elements, 3334 transcriptional control of 47-kilodalton S. cerevisiae, 10 UBF homologs, 3810 protein, 5388 Ribonuclease system rbcS-3A cyclic AMP analogs, 391 hematopoietic cells, 5983 pea differentiation, 486 phorbol ester, regulation by, 5983 phytochrome-responsive element, 5565 F9 teratocarcinoma cells, 391 transforming growth factor i1 expres- upstream region, 5565 granulocytic differentiation, 2154 sion, 5983 RCC1 gene HL-60 myeloid leukemia cells, 2154 Ribonucleoprotein point mutation mouse, 486 Drosophila species, 316 premature chromosome condensation, N-myc expression, 486 heterogeneous nuclear ribonucleoprotein 577 platelet-derived growth factor a-receptor complexes, 316 REB 1 gene Hrb98DE locus, 316 S. cerevisiae transcription promotion, 6781 protein isoforms, 316 cell growth requirement, 5226 RAR-a, 2154 Ribonucleotide reductase activity, thermo- DNA-binding protein, 5226 receptor a, 3, and y mRNAs, 391 labile myb oncogene resemblance, 5226 teratocarcinoma stem cells, 486 Chinese hamster ovary cells Recombination tissue plasminogen activator gene temperature-sensitive DNA mutant, African green monkey kidney cells, 37 expression, induction of, 5883 5688 FLP protein-promoted site-specific Retinoic acid receptor y Ribosomal DNA recombination, 235 isoform mouse, 4970 Holliday structures, 235 novel, 2335 RNA polymerase I enhancers, 4816 homologous, 492 mouse embryo, 2335 promoter, 4970 xxxviii SUBJECT INDEX MOL. CELL. BIOL.

Ribosomal DNA replicons cAMP-regulated c-myc expression, RPB1, 1908 origin control sequences 184 RPB2, 1908 amplification, 2070 human osteosarcoma cells, 184 S. cerevisiae, 1270, 1908, 1915 T. thermophila, 2070 platelet-derived growth factor, 184 stoichiometry, 1915 Ribosomal gene transcription protein kinases A and C, 184 RNA polymerase C (III) rat RNA accumulation, 184 S. cerevisiae promoter elements, enhancer and RNase MRP RPC31 gene, 4737 core, 5177 site-specific cleavage, 2191 subunit with acidic tail, 4737 stimulating factor, 5177 substrate recognition, 2191 RNA polymerase gene Ribosomal protein small nuclear RNA precursors eucaryotic transcription elongation fac- D. melanogaster nucleocytoplasmic transport, 3365 tor similarity, 5433 function in mammalian cells, 4524 processing, 3365 rpo30, 5433 S14, 4524 X. laevis oocytes, 3365 vaccinia virus, 5433 S. cerevisiae transfection RNA processing E. coli S5 ram protein, sequence and G. lamblia, 3659 mRNA functional similarity, 6544 G. lamblia RNA virus, 3659 3'-end processing, 2599 mitochondria, 4590 RNA helicase activity S. cerevisiae, 2599 mRNA-specific translational activator, eucaryotic translation initiation factors RNA self-cleavage 4590 4A and 4F, 1134 hepatitis delta virus S. cerevisiae L30, 5235 RNA modification-exclusion technique, conformational requirements, 5575 Ribosomal protein genes 4942 RNA, double-stranded ABFI factor, 2437 RNA polymerase modifying activity, ubiquitous, 5586 L2, 2437 T3 unwinding activity, ubiquitous, 5586 S. cerevisiae, 2437 mammalian cells, 4529 RNAs with multiple exons duplicated linked pair, 6097 mRNA synthesis, 4529 exon definition, 84 functional analysis, 6097 RNA polymerase I splice site selection, 84 Ribosomal protein S6 rat, 3105 RNase MRP phosphorylation, 880 RPA190 mitochondrial RNA sequences protein kinase C, 880 conditional expression, 2049 interaction, 2191 ras protein microinjection, 880 S. cerevisiae, 2049 site-specific cleavage, 2191 Xenopus oocytes, 880 termination, 2793 substrate recognition, 2191 Ribosomal protein S6 kinase transcription factors, 3105 RNR3 chicken embryo fibroblasts, 2413 X. laevis, 2793 S. cerevisiae mitogen-responsive, 2413 RNA polymerase I and II DINI, 5562 ppgorsk 2413 gene transcription, 2893 rol-6 Xenopus S6 kinase II, 2413 topoisomerase II inhibition, 2893 C. elegans, 2081 Ribosomal protein S19 Xenopus oocytes, 2893 collagen, 2081 mRNA RNA polymerase I enhancers sqt-1, 2081 5' untranslated region, 816 mouse Rous sarcoma virus X. laevis, 816 ribosomal DNA, 4816 chicken embryo fibroblasts Ribosomal proteins RNA polymerase I transcription factor glycoprotein tyrosine phosphorylation, acidic, 2182, 2341 rUBF 837 S. cerevisiae, 2182 DNase footprints, 3810 transformation, 837 S. pombe, 2341 rat, 3810 RPA190 single-copy genes UBF homologs, 3810 conditional expression, 2049 disruption, 2182 xUBF RNA polymerase I, 2049 Ribosomes DNase footprints, 3810 S. cerevisiae, 2049 inactivation, enzymatic frog, 3810 RPB1 ricin toxin A chain Arg-180 and Glu- RNA polymerase II RNA polymerase II subunits, 1908 177, 6257 largest subunit RPB2, 1908 Ricin toxin A chain C-terminal domain, lacking, 5558 S. cerevisiae, 1908 ribosome inactivation, enzymatic, 6257 transcription initiation complexes, RPB2 RIP60 5558 RNA polymerase II subunits, 1908 DNA bending enhancement upstream activation, 5558 RPB1, 1908 dihydrofolate reductase origin of repli- mammalian, 6335 S. cerevisiae, 1908 cation, 6236 mutants defective in transcription, 1010 RPC31 gene DNA binding, origin specific, 6225, 6236 S. cerevisiae, 1010 S. cerevisiae DNA helicase activity, ATP-dependent, mutation, 6123 RNA polymerase C (III) subunit, 4737 6225 RNA polymerases I and III, 6123 rpo3O RIP100, 6225 subunit, common, 6123 vaccinia virus RNA polymerase gene RIPIOO suppressor, 6123 eucaryotic transcription elongation DNA binding, origin specific, 6225 specific transcription factor similarity, 5433 DNA helicase, ATP-dependent, 6225 transcription factors IIA, IID, and RPO41 RIP60, 6225 IIB, 6335 S. cerevisiae, 10 RNA transcription-competent complex for- rRNA antisense-fos mation, 6335 SS, 2390 partial reversion of phenotypes, 1545 transcription termination site D. melanogaster pre-rRNA c-Ha-ras-transformed cells, 1545 in vitro analysis, 5782 spacer promoters, 4667 double-stranded RNA polymerase II subunit transcription activation, 4667 c-Ha-ras gene expression, induction composition, 1915 pre-18S rRNA processing in vitro, 3868 of, 4424 conditional mutations, 1270 pre-rRNA processing complex, 4920 mitochondrial, 2191 interactive domains, 1908 S. cerevisiae, 2390 c-myc phosphorylation, 1915 transcription activation, 4667 VOL. 10, 1990 SUBJECT INDEX xxxix rRNA gene activity ANBI gene CPI, 2458 pea leaf development, 842 constitutive activation region, 5921 CUP2 rUBF hypoxic consensus operator, 5921 DNA binding, 4778 DNase footprints, 3810 apoiso-l-cytochrome c metal dependence, 4778 rat, 3810 mitochondrial targeting, 5763 single amino acid change, 4778 UBF homologs, 3810 structural domains, functionally inde- CYCI, 1297 pendent, 5763 cytochrome c oxidase S5 ram protein apoiso-l-cytochrome c fusion proteins mitochondrial import, 4984 E. coli mitochondrial targeting, 5753 presubunit Va, 1873 S. cerevisiae ribosomal protein, se- ARGI mRNA, 1226 subunit Va, leaderless form, 4984 quence and functional similarity, ARG3 mRNA, 1226 D. melanogaster scaffold-attached re- 6544 arginine-specific repression, 1226 gions S6 kinase ARS binding factor I, 810 autonomous replication, 5455 activation ARS core consensus sequence DBF2 gene product homologous with p34cdc2 kinase activation, 310 mutational analysis, 3917 protein kinases, 1358 Ha-rasva- 12,Thr-59 310 ARS mutations, 265 DDR48 Xenopus oocytes, 310 ARS-binding protein function, 3174 S6 phosphorylation transcription activation, synergistic, mutagenesis, 3174 biphasic, 2787 887 structure, 3174 chicken embryo fibroblasts, 2787 ATF/CREB-like repressor defective glucose repression, 4518 S6 protein kinase II homologs GCN4 activator protein binding site dihydrolipoyl transsuccinylase, 4221 activation, 3204 similarity, 5077 DIN] phosphorylation, 3204 autonomously replicating sequence DNA damage induction, 5562 pp9orsk binding ribonucleotide reductase regulatory regulation in somatic cells, 3204 telomeric and nontelomeric, 810 subunit, 5562 X. laevis, 3204 autonomously replicating sequence RNR3, 5562 S6 ribosomal protein mutations, 265 dispersed repeated genes, 4420 phosphorylation, 880 BET], 3405 DNA repair gene, 3256 protein kinase C, 880 BOSI, 3405 DNA replication-defective mutants, 5707 ras protein microinjection, 880 C,-tetrahydrofolate synthase mutants DNA-binding protein Xenopus oocytes, 880 ADE3 gene product, noncatalytic SIN3-dependent, 1743 S14 function, 5679 transcriptional regulation, 1743 D. melanogaster, 4524 folate-dependent enzyme, 5679 dolichol phosphate mannose synthase, lack of introns, 3284 CAR] 4612 ribosomal protein, 4524 cis-acting element, 3884 glycosyl phosphatidylinositol mem- ribosomal protein gene, 3284 repressor protein binding site, 3884 brane anchoring, 5796 T. brucei, 3284 CARI (arginase) gene N glycosylation, 5796 SAAI cis-acting elements, positive and nega- 0 mannosylation, 57% murine hepatoma cells, 3619 tive, 5087 DPMI gene regulation of gene expression, 3619 induced expression, 5087 complementation of glycosylation-de- SAA2 casein kinase II, 4089 fective hamster cells, 4612 murine hepatoma cells, 3619 CDC36, 2966 E. coli regulation of gene expression, 3619 CDC39, 2966 amber suppressor, 1633 SAA3 CDC42 aminoacyl-tRNA synthetase, 1633 murine hepatoma cells, 3619 G25K cDNA, 5977 endoplasmic reticulum regulation of gene expression, 3619 human homolog, 5977 protein import, 6024 SAC7 cell cycle, 1358 Sec62p, 6024 actin mutations, temperature-sensitive, cell cycle arrest, 217 endoplasmic reticulum protein, 3013 suppression, 2308 cell-cell interaction, 2202 ENOI and EN02 enolase genes null alleles, 2308 centromere-binding protein, 2458 ABFI protein, 4872 S. cerevisiae, 2308 centromeres RAPI, repressor activator protein, chromatin structure, 5721 4872 5S rRNA chromatin, 2390 nucleosome depletion, 5721 transcription repression or activation, ABFI factor, 2437 chromosome instability mutants, 223 4872 acid phosphatase chromosome pairing, 2379 upstream activation sites, 4872 negative regulators, 5950 CIT2, 1399 EN02 gene transcriptional regulation, 5950 citrate synthase repression, 4863 ACOI, 3551 peroxisomal, 1399 upstream activation site, 4863 aconitase gene CKA2, 4089 farnesyl cysteine C-terminal methyl- mitochondrial, 3551 clathrin-associated protein complexes transferase mammalian ,-chain homolog, 6089 STEJ4 gene product dependence, 5071 synergistic regulation by glucose and CLN gene ferric reductase, 2294 glutamate, 3551 cell cycle arrest, 6482 G protein, 4439 actin mutations, temperature-sensitive, mating-pheromone signalling pathway, G protein subunits, 510 suppression, 2308 6482 GAL] promoter adenylate cyclase, 3873 START-I arrest, 6482 glucose repression, 4757 adenylyl cyclase conversion to mitochondrial DNA, 1530 GAL4 protein RAS-responsive domains, 2539 courtship, 2202 association with GAL80 protein, 2916 ADHI gene, 859 COX5b conserved domain structure, 2916 ADP ribosylation factor transcription, 5510 purification, 2916 encoded by two genes, 6690 upstream activation and repression GAL4-binding sites, 1432 essential protein, 6690 elements, 5510 GAL genes a2 repressor, 2247 COX6, 1297 UASG, opposing transcriptional regu- xl SUBJECT INDEX MOL. CELL. BIOL.

latory elements, 5663 ion transport, 643 DNA-binding specificity and affinity, Ga, 2582 IRA2, 4203 5128 GCN2 protein kinase iron uptake, 2294 PQ box, 6809 positive-acting domains, 2820 K28, double-stranded RNA killer virus, pre-mRNA processing in nuclei GCN4 activator protein 4807 distribution of factors involved in, ATF/CREB-like repressor, 5077 KGD2 3524 binding site mutations, 5077 regulation, 4221 pre-mRNA splicing, 324 optimal half-site for binding, 5077 structure, 4221 protein sorting, 3737 GCN4 expression, 2820 KRE5 gene, 3013 proteolipid gene, 3397 GCR1 gene L2 ribosomal protein genes, 2437 PRP4 protein, 1217 EN02 repression, 4863 L30, 5235 PRP6 gene null mutation, 4863 MAL U4/U6 small nuclear ribonucleoprotein GCRJ product, 859 upstream activating sequence, 3797 particle protein, 6417 gcr2 mutation MAL63 activator PRP9 gene glycolytic gene expression, 6389 binding sites, 3797 U2 small nuclear ribonucleoprotein genes necessary for meiosis, 2809 mating, 2202 particle binding, 6417 genetic recombination, 2379 mating pheromone PRP18, 324 (l->6)-P-D-glucan synthesis, 3013 signal transduction pathway, 510 RADI, 2485 glucose-induced hyperaccumulation of mating pheromone response pathway, RAD2, 3256 cyclic AMP, 4518 2966 RAD6, 1017 glucose repression, 1297, 4130, 6500 mating response, 217 RAD9 glycolytic gene expression, 6389 mcm3, 5707 characterization, 6554 H2B mRNA meiosis, 6103 posttranslational action in cell cycle posttranscriptional regulation, 2687 meiotic recombination, 4420 arrest after DNA damage, 6554 H+-ATPase membrane topology, 672 RADIO, 2485 genetic analysis, 3737 MERJ, 2379 rad mutants heat shock proteins metallothionein G2 arrest, 4678 self-regulation, 1622 E. coli ACEI transcription factor, 426 UV damage repair, 4678 heteroduplex formation, 4420 gene transcription, 426 RAS, negative regulator of, 4303 high-copy-number plasmid, 3397 upstream activation sequences, 426 REBI his3 microtubule assembly, 5286 cell growth requirement, 5226 transcription in vitro, 2832 microtubule function, 223 DNA-binding protein, 5226 HIS3 gene minichromosome maintenance mutant myb oncogene resemblance, 5226 Tc, 4447 mcm3, 5707 reduced activity of cyclic AMP-depen- histone gene induction mini-Tyl elements, 2695 dent protein kinase, 4518 stationary-phase cells, stimulation of, mitochondria replication origin function, 265 6356 ribosomal protein, 4590 retrotransposition, 1017 histone H2A mitochondrial inner membrane protein, retrotransposon, 2882 growth requirement, 4905 1873 RGRI, 4130 ubiquitination site, conserved, 4905 mitotic recombination, 2485 [rho-] mitochondrial DNA, 10 histone H4 gene mRNA ribosomal protein, 5235 HML mating type locus, silent, 4932 3'-end processing, 2599 E. coli S5 ram protein, sequence and point mutations, 4932 decay, 2269 functional similarity, 6544 HML, 409 stable, 2269 ribosomal protein genes HMR, 409 translational activator, 4590 duplicated linked pair, 6097 HO nuclease recognition site, 1174 unstable, 2269 functional analysis, 6097 HOLI mutations, 643 mutant strains, 2176 ribosomal proteins HPR1 mutations conferring resistance to amino acidic, 2182 carboxy-terminal homology to TOP], acid analogs, 2941 RNA polymerase I, 2049 1439 nuclear phosphoprotein SSN6 RNA polymerase II prevention of intrachromosomal functional domain, 4744 mutants defective in transcription, excision recombination, 1439 N-terminal TPR, 4744 1010 suppression of repeat recombination, nuclear protein, 2544 mutation, 6123 1439 nuclear transport, 353 RNA polymerases I and III, 6123 HSP26 gene nucleosomes, 2247 subunit, common, 6123 transcriptional derepression during PETJ22 locus suppressor, 6123 heat shock, 6362 divergent overlapping transcripts, 3027 RNA polymerase II subunit HSP70, 1622 pheromone response, 4439 composition, 1915 human initiator tRNA gene signal transduction pathway, 2582 phosphorylation, 1915 expression and function, 4486 pheromone response element, 6809 stoichiometry, 1915 HXT2 gene PHO4, 2224 RNA polymerase II subunits, 1908 glucose transport, high affinity, 5903 phosphatase, 1049 conditional mutations, 1270 hybrid mammalian-yeast Ga proteins, phosphatase regulon RNA processing, 2599 2582 transcriptional control, 2224 RNR3 3-hydroxy-3-methylglutaryl coenzyme A phosphoglucomutase isozyme gene DIN], 5562 reductase, 672 transcription, galactose inducible and RPA190 IMEJ, 2104 glucose repressible, 1415 conditional expression, 2049 meiosis regulation, 6103 PHR1 RPB1, 1908 IME2, 2104 damage inducibility, 4630 RPB2, 1908 interacting genes required for transport polyomavirus promoters, 947 RPC31 gene endoplasmic reticulum, 3405 positive regulatory protein, 2224 RNA polymerase C (III) subunit, 4737 Golgi complex, 3405 PPR1 protein RP041, 10 interactive domains, 1908 C6 zinc finger, 5128 S. pombe transcription factor PGA4, VOL. 10, 1990 SUBJECT INDEX xli

1432 Ty acidic, 2341 SAC7 multimeric arrays, 2882 S. cerevisiae GAL4-binding sites, 1432 null alleles, 2308 transposition, 1017 small nuclear ribonucleic acids SEC22, 3405 Tyl element, 2695 distribution, 3524 Sec62p Tyl and Tyl-mediated gene expression transcription factor PGA4, 1432 endoplasmic reticulum, 6024 activation, 3541 U 1 small nuclear RNA, 2874 membrane bound, 6024 U4 small nuclear RNA, 1217 scid pre-B cells structure and function, 6024 U14 small nuclear RNA V(D)J recombination, 5397 sequence similarity to essential genes 18S rRNA production, 1145 SCL gene D. discoideum, 2367 ubiquitin-conjugating enzyme, 1017 human SASI, 2367 upstream activation sequence, 947 formation from a transcriptionally SAS2, 2367 URA3 promoter, 0, 0 complex locus, 6426 silent mating-type genes, 409 vacuolar acidification, 3737 scon-2 negative regulatory gene simian virus 40 promoters, 947 vacuolar morphogenesis and function, N. crassa, 5207 SIN3 gene 2214 Sea urchin embryos amphipathic helix motifs, 5927 vacuolar protein sorting H2B histone gene activation, late HO, negative regulator of, 5927 VPS34 gene, 6742 3' enhancer element, unusual, 6730 single-copy genes vacuole SEC22 disruption, 2182 biogenesis, 4638 interacting genes required for transport SLPI, 2214 protein sorting, 4638 endoplasmic reticulum, 3405 small nuclear ribonucleic acids vacuole segregation Golgi apparatus, 3405 distribution, 3524 VPS34 gene, 6742 S. cerevisiae, 3405 SNFI, 1297 vanadate-resistant mutants Sec62p SNF3 glucose transporter, 1105 growth control, 898 endoplasmic reticulum SNF5 protein protein phosphorylation, 898 protein import, 6024 glutamine and proline rich, 5616 Vps33p S. cerevisiae transcriptional activator, 5616 characterization, 4638 endoplasmic reticulum, 6024 SNF6, 2544 YPKI gene product membrane bound, 6024 snRl28 phosphotyrosyl protein, 40 kilodalton, structure and function, 6024 18S rRNA production, 1145 6244 Selenocysteine tRNA[Srr]Sec gene, 1940 sphingolipids, 2176 protein-tyrosine kinase activity, 6244 SerH3 SP012, 2809 zymogen activation, 3737 T. thermophila SP016, 2809 Sarcophaga peregrina temperature-regulated surface antigen, sporulation-specific genes antibacterial proteins 6091 activation, 2104 sarcotoxin II gene cluster, 6114 Serine(threonine) protein kinase positive control, 2104 Sarcotoxin II 42-kilodalton phosphotyrosyl protein, SPT6 gene gene cluster, 6114 3020 amino terminus, acidic, 4935 S. peregrina antibacterial proteins, 6114 tyrosine-phosphorylated, 3020 nuclear protein, 4935 SAS] Serum amyloid A SSA3 D. discoideum, 2367 murine hepatoma cells, 3619 gene, 2367 HSP70 3262 SAS2, regulation of gene expression, 3619 transcriptional regulation, 3262 sequence similarity SSN6, 1297 essential genes, 2367 SAA1, 3619 STE4 overexpression, 217 S. cerevisiae, 2367 SAA2, 3619 sum]-l mutation, 409 SAS2 SAA3, 3619 T7 RNA polymerase D. discoideum, 2367 Serum amyloid A3 gene signal-mediated import, 353 SAS], 2367 mouse target gene transcription, 353 sequence similarity C/EBP-binding sequences, 6624 TATA-binding proteins essential genes, 2367 cell-specific expression, 6624 specificity, 3859 S. cerevisiae, 2367 Serum amyloid A protein TECI Scaffold-attached regions hamster cells, 4412 cloning, 3541 D. melanogaster herpes simplex virus type 2 transforma- molecular analysis, 3541 ARS elements, 5442 tion, 4412 transcription, 4935 autonomous replication, 5455 mRNAs, related, 4412 transmembrane domains, 672 nuclear scaffold binding, 5442 Serum response factor trifluoperazine resistance, 3397 S. cerevisiae, 5455 c-fos, 5553 tRNA splicing, 1049 X chromosome, 5455 phosphorylation tRNA synthesis, 4737 yeasts, budding and fission, 5442 phospholipase C-type reaction inhibi- tRNATrP gene Schizosaccharomyces pombe tor, 5553 oligonucleotide-directed mutagenesis, byri, 549 1863 Sgs-3 glue gene 4379 centromere, D. melanogaster opal suppressor, 4379 mating-type genes TRPI/ARSI chromatin, 2247 starvation-induced transcription, 549 fine-structure mutational analysis, tubulin pre-mRNA processing in nuclei 5991 alpha-tubulin, 5295 distribution of factors involved in, promoter elements, stage and tissue beta-tubulin, 5295 3524 specific, 5991 gene copy number, 5286 radl SH2 domain overproduction, 5295 analysis, 3750 p60csrc, 2855 phenotype, 5295 cloning, 3750 point mutations, 2855 regulation, 5286 rasi, 549 SH2- and SH3-coding domains TUF/GRF/RAP binding sites, 859 retrotransposons p6oc-src activation, 1307 TUPI two related families, 6791 c-src glucose repression, 6500 ribosomal proteins site-directed mutagenesis, 1307 xlii SUBJECT INDEX MOL. CELL. BIOL.

Signal recognition particle muscle-specific activity, 3468 transcription stimulation, 1811 Alu domain c-ski proteins tissue plasminogen activator gene assembly, 777 characterization, 3137 F9 teratocarcinoma cell differentiation, binding to RNA, 777 chicken, 3137 5883 dimerization of protein components, 777 SLPI retinoic acid induction, 5883 Signal transduction pathway S. cerevisiae, 2214 transcription factor, 5883 cAMP-dependent protein kinases, 3824 vacuolar morphogenesis and function, Spl binding activity interleukin-l, 3824 2214 enhancement, 95 Simian virus 5 Small nuclear ribonucleic acids gamma globin gene mutation, 95 hemagglutinin-neuraminidase distribution in yeast cell nucleus, 3524 human, 95 assembly, 1989 S. cerevisiae, 3524 Spl displacement folding, 1989 S. pombe, 3524 (-globin promoter glycosylation, 1989 Small nuclear ribonucleoprotein protein-DNA interactions, 282 N-linked oligosaccharide chains, 1989 autoimmune disease, 430 human, 282 transport, 1989 fibrillarin, 430 NF-E1, 282 Simian virus 40 U3, 430 Spl transcription factor aberrant splicing, 1805 X. laevis, 430 HL-60 leukemia cells carcinogen-induced DNA amplification, Small nuclear ribonucleoprotein particle DNA-binding activity, 5541 75 D' core protein, 4480 expression, 5541 Chinese hamster cells, 75, 4345 D. melanogaster, 2492 SP6 plasmid-generated mRNAs chromatin assembly, 2863 U 1 70K protein nuclear transport of proteins, 1287 downstream promoter element, 3635 gene expression, 2492 Spermatocyte enhancer and promoter elements gene structure, 2492 D. melanogaster, 131 substitution for an upstream activation Small nuclear ribonucleoprotein particle hsp26 gene, 131 sequence in S. cerevisiae, 947 protein regulatory elements, 131 homologous recombination enhance- SmN Spermatozoa ment, 794 embryonic stem cell differentiation, A. californica large T antigen 6817 protein kinase, cyclic AMP depen- adenovirus early region 1, 6664 Small nuclear RNA dent, 6775 fibroblasts, conditional immortaliza- precursors Sphingolipids tion of, 6664 nucleocytoplasmic transport, 3365 S. cerevisiae large-T-antigen-binding domains processing, 3365 mutant strains, 2176 retinoblastoma gene product hyper- X. laevis oocytes, 3365 Splice site selection phosphorylation, 6586 U6 exon definition, 84 nucleosome assembly, 2863 evolutionary origin, 5548 RNAs with multiple exons, 84 origin auxiliary sequences intron, 5548 Splicing DNA unwinding, 1719 Small-t intron AMPDI T-antigen binding, 1719 aberrant splicing, 1805 5' splice donor site, alternative, 5271 origin region overreplication, 75 simian virus 40, 1805 alternative pathway, 5271 preinitiation complex, assembly of, 3635 smg-211rapllKrev-1 proteins RNA intermediate, 5271 replication c-ras p2ls, 2645 pre-mRNA chromosomally replicated SV40, 4345 subcellular distribution, 2645 PRP18, 324 retinoblastoma susceptibility gene prod- tissue distribution, 2645 S. cerevisiae, 324 uct smg p25A SP012 minimal T- and ElA-binding domain, GDI, 4116 S. cerevisiae, 2809 3761 regulatory protein, 4116 SP016 small-t intron, 1805 SmN S. cerevisiae, 2809 T antigen, 794 small nuclear ribonucleoprotein particle Sporulation-specific genes T antigen phosphorylation protein activation, 2104 human protein kinase, DNA activated, embryonic stem cell differentiation, IMEI, 2104 6472 6817 IME2, 2104 Z-DNA motif d(TG)30, 794 SNFI positive control, 2104 SIN3 gene COX6, 1297 S. cerevisiae, 2104 S. cerevisiae CYCi, 1297 SPT6 gene amphipathic helix motifs, 5927 S. cerevisiae, 1297 S. cerevisiae HO, negative regulator of, 5927 SSN6, 1297 amino terminus, acidic, 4935 SIN3-dependent DNA-binding protein SNF3 glucose transporter nuclear protein, 4935 S. cerevisiae, 1743 S. cerevisiae, 1105 transcription, 4935 transcriptional regulation, 1743 SNF5 protein sqt-J Single-copy genes S. cerevisiae C. elegans, 2081 disruption, 2182 glutamine and proline rich, 5616 collagen, 2081 ribosomal proteins transcriptional activator, 5616 rol-6, 2081 acidic, 2182 SNF6 src S. cerevisiae, 2182 nuclear protein, 2544 v-abl replacement v-sis S. cerevisiae, 2544 lymphoid transformation, 4365 B-protein domain snR128 insulinlike growth factor I receptor conformational changes, 5496 18S rRNA production, 1145 phosphorylation, 3626 receptor interaction, 5496 S. cerevisiae, 1145 regulation transforming activity, 5496 Somatic cell fusion chicken embryo fibroblasts, 1301 platelet-derived growth factor, 5496 neuroblastoma cells, 5416 human glucose transporter, 1301 Skeletal troponin I promoter Spi Swiss 3T3 cell line, resistant, 4155 interaction between regulatory se- GHF-1 displacement, 1811 transformation quences and elements, 3468 growth hormone gene promoter chicken cells, 3626 VOL. 10, 1990 SUBJECT INDEX xliii c-src Surfeit locus TATA-dependent and TATA-independent chicken skeletal muscle, 4068 CpG-rich islands and genes, 605 interactions non-tyrosine protein kinase product, mouse, 605 HSP gene promoter 4068 Swiss 3T3 cell line factor substitution, 165 p6f,c-src activation, 1307 resistance to src and TPA, 4155 human, 165 SH2- and SH3-coding domains, 1307 TATA-dependent/TATA-independent pro- site-directed mutagenesis, 1307 t(6;9) moter C-SRC exon acute nonlymphocytic leukemia, 4016 tissue-specific expression, 5646 human brain, 2035 transcription of gene on 9q34, 4016 TAX, v-src gene products T3 human T-cell leukemia/lymphoma virus transforming growth factor 131 promoter RNA polymerase type I AP-1 complex, 4978 mRNA synthesis, 4529 indirect interaction with long terminal transcriptional regulation, 4978 T7 RNA polymerase repeat, 4192 src protein nuclear transport, 353 Tc membrane attachment, 1000 S. cerevisiae nucleus, 353 S. cerevisiae HIS3 gene, 4447 SSA3 signal-mediated import, 353 T-cell antigen receptor-CD3 complex ETS-2 protein S. cerevisiae, 3262 target gene transcription, 353 transcriptional regulation, 3262 T antigen- and ElA-binding domain phosphorylation, 1249 SSN6 T-cell receptor a gene retinoblastoma susceptibility gene prod- human COX6, 1297 uct, 3761 CYCI, 1297 enhancer elements, hypomethylated, S. cerevisiae, 1297 simian virus 40, 3761 4720 SNFI, 1297 T cell enhancer regulation, 4720 SSN6 nuclear phosphoprotein CD4 and CD8 cross-linking, 5305 nuclear protein interaction, 5486 functional domain, 4744 maturation nuclear proteins, T-cell specific, 4720 N-terminal TPR, 4744 lck mRNAs, 4266 T-cell receptor P gene, 5486 S. cerevisiae, 4744 mouse, 4266 transcriptional regulatory elements, START-I arrest mouse 5486 S. cerevisiae novel gene on chromosome 8, 3663 T-cell receptor a enhancer CLN gene, 6482 p56Ick phosphorylation, 5305 mouse Stationary-phase cells, stimulation of, 6356 surface molecules, 5305 DNA-binding proteins, 5027 S. cerevisiae, 6356 tyrosine protein kinase, 5305 functional analysis, 5027 histone gene induction, 6356 T cells, activated T-cell receptor a gene STE4 overexpression Ly6E/A differentiation antigen human cell cycle arrest, 217 interferon induction, 5150 nuclear protein interaction, 5486 mating response, 217 promoter elements, 5150 T-cell receptor a gene, 5486 S. cerevisiae, 217 T lymphocytes transcriptional enhancer, 5486 STE14 gene human TECI S. cerevisiae cloning, 3541 serine protease gene, farnesyl cysteine C-terminal methyl- CSP-B cytotoxic molecular analysis, 3541 transferase, 5071 5655 S. cerevisiae, 3541 Steroid hormone T-antigen binding Tyl and Tyl-mediated gene expression 85-kilodalton heat shock protein, 273 DNA unwinding, 1719 activation, 3541 A. ambisexualis, 273 SV40 origin auxiliary sequences, 1719 TED heat shock protein, 273 tapa-l baculovirus genome hsp85, 273 cloning, 4007 integration, 3067 receptor complex, 273 transmembrane proteins, a new family gene organization, 3067 regulation, 273 of, 4007 T. ni, 3067 Stress induction TA-rich recognition protein-binding regula- transcription, 3067 basal promoter requirements, 3125 tory elements Telomere HSP70 promoter, 3125 creatine kinase genes composition, 3421 human, 3125 brain, 4826 DNA-protein interactions Stress response, avian, 4886 muscle, 4826 characterization, 3421 Stromelysin mRNA TATA box E. crassus, 3421 epidermal growth factor stimulation alcohol dehydrogenase gene, human human c-fos, 4284 C/EBP binding, 5007 replication timing of associated DNA c-jun, 4284 trans activation, 5007 sequences, 6348 protein kinase C, 4284 TATA element structure, 3421 rat fibroblasts, 4284 GCN4 activation, 4256 telomere-binding protein Strongylocentrotus purpuratus TATA elements isolation, 3421 poly(A)-binding proteins, 3994 HSP70 gene promoter substitution Teratocarcinoma Subtelomeric repeats mutants mouse, 486 organization, 2423 P. berghei, 2423 Ela transactivation, 176 N-myc expression, 486 suml-l mutation human, 176 retinoic acid-induced differentiation, 486 176 Teratocarcinoma cell line S. cerevisiae, 409 upstream elements, silent mating-type gene, 409 TATAA-less promoter human, 1793 Surface antigen gene expression GC box, 6632 ras-like genes, 1793 multilevel regulation, 1538 transcriptional activation, 6632 Termination region P. tetraurelia, 1538 TATA-binding proteins T. lanuginosus, 377 Surface antigen, temperature regulated human, 3859 Testicular germ cells T. thermophila S. cerevisiae, 3859 mak, 2261 SERH3, 6091 specificity, 3859 mammalian protein kinase gene, 2261 xliv SUBJECT INDEX MOL. CELL. BIOL.

Testis Thyroid epithelial cells Transcription elongation factor, eucaryotic rat human vaccinia virus rpo3O RNA polymerase glutamic acid decarboxylase expres- immortalization, conditional, 5365 gene similarity, 5433 sion, 4701 oncogene action, 5365 Transcription factor spermatogenesis, 5021 Thyroid peroxidase gene AGP/EBP tyrosine kinase FER human C/EBP family member, 6642 testis-specific transcript (ferT), 5021 thyroid-specific enhancer, 6216 inactive in tumorigenic cells, 4100 Testis-specific H2B (TH2B) histone gene Thyroid/steroid receptor family PTF1 rat, 585 NGFI-B protein DNA-binding activity, 254 regulatory elements, 585 posttranslational modification, rapid, mouse, 254 12-O-tetradecanoylphorbol- 13-acetate re- 6454 pancreas-specific mRNA synthesis, sponse element Tissue plasminogen activator gene 254 cyclic AMP response element, 1609 retinoic acid, induction of expression by, TFIID, partially proteolyzed c-Jun, 1609 5883 DNA-binding and transcriptional prop- mXBP/CRE-BP2, 1609 F9 teratocarcinoma cell differentiation, erties, 3415 Tetrahymena thermophila 5883 human, 3415 3' exon, 2960 Spi, 5883 Transcription factors IIA, IID, and IIB 3' splice site specificity, 2960 transcription factor, 5883 specific transcription, 6335 group I intron, 2960 T-lymphocytic cell lines mammalian, 6335 internal guide sequence, 2960 c-Myb transcription-competent complex, 6335 origin control sequences c-myc promoter trans-activation, 5747 Transcription initiation amplification, 2070 TOPI dihydrofolate reductase promoter, 653 ribosomal DNA replicons, 2070 carboxy-terminal homology, 1439 HIPI, 653 rRNA intron HPRI Transcription initiation complexes self-splicing, 2960 carboxy-terminal homology, 1439 RNA polymerase II SerH3 gene suppression of repeat recombination, C-terminal domain of largest subunit, temperature-regulated surface antigen, 1439 lacking, 5558 6091 Topoisomerase II upstream activation, 5558 TFIID inhibition, 2893 Transcription termination site DNA-binding and transcriptional proper- RNA polymerase I and II genes, 2893 RNA polymerase II ties, 3415 Xenopus oocytes, 2893 in vitro analysis, 5782 human, 3415 Topoisomerase II sites Transcriptional activator Krox-24 proteolyzed, partially, 3415 chicken, 2774 Krox-24, 3456 TFIIIA-binding site DNase I-hypersensitive sites, 2774 mouse, 3456 5S RNA gene, 5166 ,B-globin locus, 2774 Transcriptional arrest sites X. Iaevis, 5166 TPR human TFIIIC S. cerevisiae adenosine deaminase gene, 4555 transcriptionally active functional domain, 4744 Transformation HeLa cells, poliovirus-infected, modi- nuclear phosphoprotein SSN6, 4744 marker fication in, 5106 trans activation C. neoformans var. neoformans URA5 TH2B gene alcohol dehydrogenase gene, human, gene, 4538 rat, 585 5007 Transforming growth factor a regulatory elements, 585 MRF4, 3934 processing Thermomyces lanuginosus v-myb, 2285 arterioles, 4596 rRNA, 377 MyoDI, 3934 cell surface, 4596 termination region, 377 myogenin, 3934 elastases, 4596 Thy-l gene trans-Acting factor precursor, 4596 DNA signal, 4396 M-CAT binding factor, 4271 Transforming growth factor alpha gene methylation patterns, 4396 trans-Acting factors characterization, 2111 mouse embryonic stem cells, 4396 functional complementation, 5055 promoter sequences, 2111 Thymidine kinase interferons, induction by, 5055 rat, 2111 pre-mRNA trans-Activator protein Transforming growth factor 1P ordered splicing, 5591 H2B AP-1 complex, 1492 S phase of cell cycle, 5591 cell growth inhibition, 3258 autoinduction, 1492 Thymidine kinase gene transcription inhibition, 3258 hematopoietic cells G,-S-phase-regulated region, 3834 viral, 3258 gene expression, 5983 human, 3834 Transactivator Vmw65 phorbol ester-regulated ribonuclease promoter, 3834 herpes simplex virus type 1 system, 5983 kinase Oct-l, 4974 Transforming growth factor 1P promoter Thymidine promoter protein-DNA complex assembly, 4974 transcriptional regulation lens activation, species specific Transcription AP-1 complex, 4978 mouse aA-CRYBPI site, 6813 activation v-src gene products, 4978 tissue specificity, loss of by multimer- GAL4, 4623 Transforming growth factor 13 ization, 6813 control, 4495 biological activities, 4473 [3H]thymidine labeling protocols CYP2EI gene, 4495 osteoblasts, 4473 cell cycle progression, 1584 D. melanogaster pre-rRNA, 4667 receptor-binding properties, 4473 Chinese hamster ovary cells, 1584 mammalian cells, 4837 Transforming growth factor 13 family DNA replication, 1584 premature termination D. melanogaster, 2669 Thyroglobulin promoter ax-tubulin gene, 727 dpp protein, 2669 gene expression in hybrid cells, 1033 X. laevis oocytes, 727 Translational control Thyroid cells recombination, homologous, stimulation maturation specific hybrids, 1033 of, 4837 cytoplasmic polyadenylation elements, thyroglobulin promoter, 1033 spacer promoters, activation, 4667 5634 VOL. 10, 1990 SUBJECT INDEX xIv

poly(A) tail size diversity, 5634 parp genes, 3036 Tumor necrosis factor-responsive tran- stable polyadenylation complexes, phospholipase C scription factor 5634 chromosomal localization, 720 hemopoietic growth factor genes, 2950 Translational initiation developmental regulation, 720 regulatory elements, 2950 enhancer of, 3441 genomic organization, 720 Tumorigenesis poly(A) tail of mRNA, 3441 procycic acidic repetitive protein p53 protein Transmembrane protein a-amanitin-resistant transcription unit, nuclear accumulation, 6565 H-2KItws region, 138 3492 TUPI histidine-rich charge clusters, 138 promoter analysis, 3492 S. cerevisiae mouse, 138 procyclic acidic repetitive protein genes glucose repression, 6500 new family, 4007 transcription, 3036 Ty TAPA-1, 4007 ribosomal protein gene, 3284 multimeric arrays, 2882 trans-Splicing S14 retrotransposon, 2882 C. elegans mRNAs, 1764, 1769 lack of introns, 3284 S. cerevisiae, 2882 trimethylguanosine cap, 1764, 1769 trypanosome leucine repeat gene Tyl element Trichoplusia ni protein-binding domains of yeast, mini-Tyl elements, 2695 baculovirus genome Drosophila, and mammalian pro- S. cerevisiae, 2695 integration, 3067 teins, resemblance to, 6436 Tyl and Tyl-mediated gene expression retrotransposon, 3067 putative metal-binding domain, 6436 activation TED, 3067 variant surface glycoprotein expres- TECI, 3541 Trifluoperazine resistance sion site, 6436 S. cerevisiae, 3541 high-copy-number plasmid, 3397 Trypanosome leucine repeat gene Type IV collagenase proteolipid gene, 3397 T. brucei human S. cerevisiae, 3397 protein-binding domains of yeast, transcriptional elements, positive and Trimethylguanosine cap Drosophila, and mammalian pro- negative, 6524 C. elegans mRNAs, 1764, 1769 teins, resemblance to, 6436 Tyrosine Triosephosphate isomerase putative metal-binding domain, 6436 colony-stimulating factor I receptor, mRNA translation variant surface glycoprotein expres- 2991 penultimate exon, 5215 sion site, 6436 mouse, 2991 Tritiated thymidine labeling protocols tsBN2 gene phosphorylation, 2991 cell cycle progression, 1584 premature chromosome condensation, Tyrosine aminotransferase gene Chinese hamster ovary cells, 1584 577 chromatin structures, 3334 DNA replication, 1584 TSE1 cis-acting elements, 3334 trk oncogenes phosphoenolpyruvate carboxykinase rat, 3334 activation, 4202 genes Tyrosine kinase human, 4202 regulation, 2660 epidermal growth factor receptor-phos- tyrosine kinase domain, 4202 Tubulin pholipase C-y association, 435 tRNA S. cerevisiae fibroblast growth factor, acidic, 4770 gene, 4486 alpha-tubulin, 5295 heparin-binding growth factor 1, 4770 human initiator, 4486 beta-tubulin, 5295 phospholipase C--y, 4770 tRNA splicing gene copy number, 5286 phospholipase C-y-epidermal growth S. cerevisiae phosphatase, 1049 microtubule assembly, 5286 factor receptor association, 435 tRNA synthesis overproduction, 5295 S. cerevisiae, 4737 phenotype, 5295 Tyrosine kinase FER tRNA[SerlSec regulation, 5286 spermatogenesis, 5021 selenocysteine, 1940 a-Tubulin gene testis-specific transcript (ferT), 5021 tRNATrp premature transcription termination, 727 Tyrosine phosphorylation oligonucleotide-directed mutagenesis, X. laevis oocytes, 727 BALB/c 3T3 cells, 2528 4379 TUF/GRF/RAP binding sites FDC-PI cells, 2528 opal suppressor, 4379 ADHI gene, 859 c-fms proteins, 2528 S. cerevisiae, 4379 GCRI product, 859 keratinocyte differentiation, 1164 Tropomyosin S. cerevisiae, 859 macrophage colony-stimulating factor, alpha-tropomyosin gene, 1729 Tumor necrosis factor 2528 alternative promoters, 1729 hsp28 Tyrosine protein kinase alternative RNA processing, 1729 phosphorylation, 1276 CD4, 1853 isoforms, 1729 human fibroblasts, 1982, 3818 CD8, 1853 rat brain, 1729 induction of gene sequences, 1982 p56ck, 1853 Troponin I promoter interleukin-6 induction, 3818 autophosphorylation site, 5305 interaction between regulatory se- a CD4 and CD8 cross-linking, 5305 3468 Tumor necrosis factor quences and elements, immediate-early response gene induc- phosphorylation, 5305 muscle-specific activity, 3468 T cells, 5305 skeletal, 3468 tion, 5830 TRPl/ARSl chromatin major histocompatibility complex class a2 repressor, 2247 II-associated invariant chain, 4146 U 1 70K protein nucleosomes, 2247 transcription regulation in macrophages D. melanogaster, 2492 S. cerevisiae, 2247 KB-like motifs, 1498 gene expression, 2492 Trypanosoma brucei NF-KB forms, constitutive and induc- gene structure, 2492 3-phosphoglycerate kinase import ible, 1498 Ul RNA gene glycosomes, 4545 Tumor necrosis factor K chicken, 341 in vitro assay, 4545 mouse cooperativity between Ul gene enhancer chromosome organization, 6079 interleukin-2, 5865 motifs, 341 flagellar pocket limiting step, 5865 enhancer cysteine-rich cell surface protein, 4506 RNA processing, 5865 octamer and SPH motifs, 341 xlvi SUBJECT INDEX MOL. CELL. BIOL.

Ul small nuclear RNA polypeptides sis, 4638 S. pombe, 2874 3'-terminal exons, 5937 vRel U2 small nuclear ribonucleoprotein particle UV damage Dorsal protein, 2840 binding S. cerevisiae Rel protein, 2840 S. cerevisiae PRP9, 6417 G2 arrest, 4678 transformation U2 small nuclear RNA rad mutants, 4678 oncogenic, 2840 primate repair, 4678 evolution, 5876 UV irradiation Wnt-i promoter gene amplification, 5876 DNA-binding protein int-i promoter, 4170 multigene family, 5876 damage-specific, 2041 mouse mammary tumor virus, 4170 natural selection, 5876 primate cells, 2041 structure, 5876 UV-irradiated plasmids Xenopus embryos U3 excision repair, 3505 Xhox 36 transcripts small nuclear ribonucleoprotein X. laevis oocytes, 3505 homeobox-containing, 3376 autoimmune disease, 430 noncoding, 3376 fibrillarin, 430 Vaccinia virus Xenopus laevis X. laevis, 430 rpo3O RNA polymerase gene 5S RNA genes U4 small nuclear RNA eucaryotic transcription elongation promoter elements, intragenic, 5166 PRP4 protein, 1217 factor similarity, 5433 TFIIIA-binding site, 5166 S. cerevisiae, 1217 Vacuolar protein sorting autoimmune disease, 430 U4/U6 small nuclear ribonucleoprotein S. cerevisiae cell division, 458 particle protein VPS34 gene, 6742 diacylglycerol production, 333 S. cerevisiae PRP6, 6417 Vacuole early embryogenesis, 1516 U6 intron biogenesis, 4638 embryos, 4123 small nuclear RNA morphogenesis and function, 2214 excision repair evolutionary origin, 5548 protein sorting, 4638 UV-irradiated plasmids, 3505 U6 small nuclear RNA S. cerevisiae, 2214 fibrillarin, 430 capping SLPI, 2214 genes with homology to MyoDI, 1516 sequence-dependent, 939 Vacuole segregation hexose transporters, 743 U14 small nuclear RNA S. cerevisiae human placenta protein, 458 18S rRNA production, 1145 VPS34 gene, 6742 insulin receptor, 743 S. cerevisiae, 1145 Vanadate-resistant mutants insulin signaling pathway, 743 UASG growth control, 898 minivitellogenin mRNA, 371 transcription regulation protein phosphorylation, 898 mRNA S. cerevisiae GAL genes, 5663 S. cerevisiae, 898 5' untranslated region, 816 UBF homologs Variable-region genes stability of maternal mRNAs, 4123 DNase footprints, 3810 heavy-chain antibody oocytes, 333, 458, 727, 880, 923, 2893, rUBF, 3810 mutation distribution, 5187 3365, 3505 xUBF, 3810 VDJ recombinase plasmid repair and recombination, Ubiquitination fluorescence-based system for assaying 5849 S. cerevisiae and separating live cells, 1697 poly(A)+ RNA, mouse, injection of, conserved sequence, 4905 Vermilion gene and mutant alleles 6055 histone H2A, 4905 D. melanogaster, 1423 Ras, mammalian, prenylation of, 5945 Upstream activation sequence structure, 1423 transcriptional machinery, reprogram- E. coli transcription, 1423 ming, 6055 ACEI transcription factor, 426 Vimentin X-irradiated plasmids, 5849 metallothionein, 426 gene expression, 2349 p2lras microinjection, 333 polyomavirus promoters, 947 negative element, 2349 phosphatidylcholine metabolism, 333 S. cerevisiae, 426, 947 Vitellogenin B1 promoter phosphatidylinositide metabolism, 923 simian virus 40 promoters, 947 chromatin-assembled DNA, potentiation pp90k URA3 promoter of, 3926 regulation in somatic cells, 3204 S. cerevisiae, 0, 0 X. laevis, 3926 premature transcription termination, 727 URAS gene Vitellogenin genes, activation protein kinase C, 880 isolation from C. neoformans var. neo- Xenopus oocytes ras protein microinjection, 880 formans, 4538 albumin genes, independent activa- ras-induced maturation, 923 marker for transformation, 4538 tion, 6674 ribosomal protein S6 phosphorylation, Urate oxidase gene estrogen receptor, pure, 6674 880 D. melanogaster V(D)J recombination ribosomal protein S19, 816 ecdysone repression, 5114 scid pre-B cells, 5397 RNA polymerase I Malpighian tubules, expression in, VL30 transcriptional element termination, 2793 5114 mouse, 1 RNA polymerase I and II genes, 2893 Ustilago maydis S6 kinase II KP6 killer toxin ras activation, 1 protein homologs expression in S. cerevisiae, 1373 Vole activation, 3204 relationship to other cellular toxins, connexin43 gap junction protein phosphorylation, 3204 1373 fibroblasts, uninfected and RSV-trans- small nuclear RNA precursors structure, 1373 formed, 1754 nucleocytoplasmic transport, 3365 UV mouse fibroblasts, 1754 processing, 3365 intrachromosomal homologous recombi- phosphorylation, 1754 somite formation, 1516 nation in human cells, 3945 Vps33p topoisomerase II inhibition, 2893 UV cross-linking S. cerevisiae a-tubulin gene, 727 polypeptide binding characterization, 4638 tyrosine phosphatase microinjection, 458 Drosophila hsp7O promoter, 4233 vacuolar protein sorting and biogene- U3 small nuclear ribonucleoprotein, 430 VOL. 10, 1990 SUBJECT INDEX xlvii

vitellogenin B1 promoter, 3926 UBF homologs, 3810 Zfy-2 protein chromatin-assembled DNA, potentia- mouse, 681 tion of, 3926 Yarrowia lipolytica Zfx protein, 681 Xenopus oocytes L YS5 Zinc finger domain-containing protein albumin genes, activation, 6674 overlapping reading frames, kappa immunoglobulin gene enhancers, chromosomal vitellogenin genes, activa- 4795 1406 tion, 6674 Yeast major histocompatibility complex class I albumin genes, independent activa- H+-ATPase, 4110 gene enhancers, 1406 tion, 6674 1406 estrogen receptor, pure, 6674 Yeast artificial chromosome enhancer-binding protein 1, cyclic AMP phosphodiesterase stimula- human-derived insert, 4163 Zinc finger domains tion, 1689 modification, 4163 mouse, 418 hormone-induced maturation, 1689 transfer, 4163 Zinc finger gene c-mosx', 310 YPKI gene product Krox-20 p21, 310 S. cerevisiae transcription initiation site, serum- p34cdc2 kinase activation, 310 phosphotyrosyl protein, 40 kilodalton, responsive, 3788 ras proteins 6244 Zinc finger protein transforming, 1689 protein-tyrosine kinase activity, DNA-binding activity, 1259 Ha-rasval-l2Thr-59, 310 6244 Egr-I gene product, 1931 S6 kinase activation, 310 YPTI/SEC4 Evi-l myeloid transforming gene, Xenopus S6 kinase II epithelial cell line, 6578 1259 chicken embryo fibroblasts, 2413 related cDNAs HERV-R mRNAs, 4401 pp9QrSk 2413 cloning, 6578 identification, 1259 ribosomal protein S6 kinase Kruppel, related to, 4401 mitogen-responsive, 2413 Z-DNA nuclear localization, 1259 Xhox 36 transcripts d(TG)30 motif, 794 Zinc fingers homeobox-containing, 3376 growth hormone gene promoter, rat, A. nidulans, 1815 homeodomain protein, 3376 5378 briA, 1815 noncoding, 3376 homologous recombination enhance- Zona pellucida genes Xenopus embryos, 3376 ment, 794 developmental regulation, 1507 X-irradiated plasmids repair and recombination simian virus 40 mouse oocytes, 1507 X. laevis oocytes, 5849 T antigen, 794 Zp-2, 1507 XRCCI Z-DNA motif d(TG)30 Zp-2 human human cells, 785 mouse oocytes, 1507 DNA strand break repair correction, recombinational hotspot, 785 zona pellucida genes 6160 Zea mays developmental regulation, 1507 molecular cloning, 6160 hsp60, 3979 Zymogen activation sister chromatid exchange, 6160 mitochondrial chaperonin, 3979 H+-ATPase xUBF Zfx protein genetic analysis, 3737 DNase footprints, 3810 mouse, 681 S. cerevisiae vacuolar network, 3737 frog, 3810 Zfy-2 protein, 681 vacuolar acidification, 3737