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Rabbit Anti-SMCR7L/FITC Conjugated antibody
SL12634R-FITC
Product Name: Anti-SMCR7L/FITC Chinese Name: FITC标记的SMCR7L蛋白抗体 dJ1104E15.3; HSU79252; Hypothetical protein LOC54471; MID51; MIEF1; mitochondrial dynamic protein MID51; mitochondrial dynamic protein of 51 kDa; mitochondrial dynamics protein MID51; mitochondrial dynamics protein of 51 kDa; Alias: mitochondrial elongation factor 1; SMC7L_HUMAN; SMCR7-like protein; Smcr7l; Smith Magenis syndrome chromosome region candidate gene 7 protein like; Smith- Magenis syndrome chromosomal region candidate gene 7 protein-like; Smith-Magenis syndrome chromosome region, candidate 7-like. Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse,Rat,Chicken,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep, ICC=1:50-200IF=1:50-200 Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 51kDa Form: Lyophilized or Liquid Concentration: 1mg/mlwww.sunlongbiotech.com immunogen: KLH conjugated synthetic peptide derived from human SMCR7L Lsotype: IgG Purification: affinity purified by Protein A Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Function: Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes Product Detail: the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.
Subcellular Location: Membrane.
Tissue Specificity: Expression is relatively high in heart, skeletal muscle, pancreas and kidney.
Similarity: Belongs to the SMCR7 family.
Database links:
Entrez Gene: 54471 Human
Entrez Gene: 239555 Mouse
Entrez Gene: 315141 Rat
Omim: 615497 Human
SwissProt: Q9NQG6 Human
SwissProt: Q8BGV8 Mouse
SwissProt: Q5XIS8 Rat Unigene:www.sunlongbiotech.com 714252 Human Unigene: 728085 Human
Unigene: 307163 Mouse
Unigene: 62655 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.