CURRICULUM VITAE

RONGJUN , MD, PhD

EDUCATION Pathologist Hamamatsu University (PhD) Hamamatsu, Japan Consultants in Laboratory Medicine is privileged to include Rongjun Guo, M.D., Beijing Medical University (MS) Ph.D., as a member of our medical staff. Dr. Beijing, China Guo has extensive hospital experience with Zhengzhou University (MD) a remarkable international education and Zhengzhou, China teaching background.

POSTGRADUATE TRAINING Dr. Guo received his medical degree from Molecular Genetic Pathology Fellowship Zhengzhou University in China, where subsequently served as Baylor College of Medicine Houston, TX an Internal Medicine Physician. He then graduated from the Beijing Medical University in China with his Master of Science degree in Surgical Pathology Fellowship anatomic pathology. He received his Ph.D. in molecular pathology UT MD Anderson Cancer Center Houston, TX from Hamamatsu University in Japan as a Visiting Research Scholar before relocating to the United States for his postgraduate training. Anatomical and Clinical Pathology Residency University at Buffalo Dr. Guo went on to serve a four-year anatomic and clinical Buffalo, NY pathology residency at the University of Buffalo in New York. BOARD CERTIFICATIONS He later completed a surgical pathology fellowship at the MD Anatomical and Clinical Pathology Anderson Cancer Center of the University of Texas in Houston, Molecular Genetic Pathology followed by a molecular genetic pathology fellowship at the Baylor College of Medicine in Houston. PROFESSIONAL MEMBERSHIPS American Association for Clinical Pathology Upon concluding his medical education, Dr. Guo began serving as Association of Molecular Pathology an Assistant Professor of Pathology and a Staff Pathologist at the United States and Canadian Academy of University of Alabama at Birmingham, where he worked for four Pathology years. He has since worked as a Staff Pathologist with Consultants in Laboratory Medicine.

Dr. Guo is a member of the American Society for Clinical Pathology, the Association of Molecular Pathology and the United States and Canadian Association of Pathologists. He currently holds full medical licensure in Maryland, Michigan, New York, Ohio, Virginia and Washington, DC. He is board certified by the American Board of Pathology in anatomic and clinical pathology and molecular genetic pathology.

Dr. Guo has coauthored nearly two dozen abstracts, articles and book chapters that have subsequently been published in peer-reviewed medical journals and textbooks. He has also delivered numerous oral and poster presentations at professional medical conferences.

(See reverse for a sampling of published works.)

2130 W. Central Ave., Suite 300 Toledo, OH 43606 T 419.534.3500 F 419.534.2608 www.auroradx.com SAMPLING OF RONGJUN PUBLISHED WORKS GUO, MD, PhD

Pathologist

PUBLICATIONS

• Guo RJ, Y, Kaneko E, Wang DY, Arai H, Hanai H, Takenoshita S, Hagiwara K, Harris CC, and Sugimura H. Analyses of mutations and loss of heterozygosity of coding sequences of the entire transforming growth factor beta type II receptor gene in sporadic human gastric cancer. Carcinogenesis. 1998;19:1539-44.

• Guo RJ, Arai H, Kitayama Y, Igarashi H, Hemmi H, Arai T, Hanai H, and Sugimura H. Microsatellite instability of papillary subtype of human gastric adenocarcinoma and hMLH1 promoter hypermethylation in the surrounding mucosa. Pathol Int. 2001 Apr;51(4):240-7.

• Wang Y, Shinmura K, Guo RJ, Isogaki J, Wang DY, Kino I, and Sugimura H. Mutational analyses of multiple target genes in histologically heterogeneous gastric cancer with microsatellite instability. Japanese Journal of Cancer Research. 1998;89:1284-91.

• Yasumi K, Guo RJ, Hanai H, Arai H, Kaneko E, Konno H, Takenoshita S, Hagiwara K, and Sugimura H. Transforming growth factor beta type II receptor (TGF beta RII) mutation in gastric lymphoma without mutator phenotype. Pathol Int. 1998;48:134-7.

• Yoshii S, Tanaka M, Otsuki Y, Wang DY, Guo RJ, Y, Takeda R, Hanai H, Kaneko E, and Sugimura H. alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase. Oncogene. 1999;18(41):5680-90.

• JP, Kitayama Y, Igarashi H, Guo RJ, Wang RJ, Kobayashi T, Konno H, Kataoka H, Tanaka M, and Sugimura H. Centromere numerical abnormality in the papillary, papillotubular type of early gastric cancer, a further characterization of a subset of gastric cancer. Int J Oncol. 2002;21(6):1205-11.

• Govindarajan R, S, Song XH, Guo RJ, Wheelock M, Johnson KR, and Mehta PP. Impaired trafficking of connexins in androgen-independent human prostate cancer cell lines and its mitigation by alpha-catenin. J Biol Chem. 2002;277(51):50087-97.

• Lynch J, Keller M, Guo RJ, D, and Traber P. Cdx1 inhibits the proliferation of human colon cancer cells by reducing cyclin D1 gene expression. Oncogene. 2003;22:6395-407.

• Guo RJ, E, Ezaki T, Patel N, Sinclair K, J, Klein P, Suh ER, and Lynch JP. Cdx1 inhibits human colon cancer proliferation by reducing beta- catenin/T-cel factor transcriptional activity. Journal of Biological Chemistry. 2004;279(35):36865-75.

• Keller M, Ezaki T, Guo RJ, and Lynch JP. Cdx1 or Cdx2 expression activates E-cadherin-mediated cell-cell adhesion and compaction in human COLO 205 cells. Am J Physiol Gastrointest Liver Physiol. 2004;287(1):G104-14.

• Guo RJ, Suh ER, and Lynch JP. The role of Cdx proteins in intestinal development and cancer. Cancer Biology and Therapy. 2004;3(7):593-601.

• Ezaki T, Guo RJ, H, Reynolds AB, and Lynch JP. The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylation. Am J Physiol Gastrointest Liver Physiol. 2007;293(1):G54-65.

• Funakoshi S, Ezaki T, J, Guo RJ, and Lynch JP. Repression of the desmocollin 2 gene expression in human colon cancer cells is relieved by the homeodomain transcription factor Cdx1 and Cdx2. Mol Cancer Res. 2008;6(9):1478-90.

• Crissey , Guo RJ, Fogt F, Li H, Katz JP, Silberg DG, Suh ER, and Lynch JP. The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine. Neoplasia. 2008;10(1):8-19.

• Guo RJ, F, and Heffner R. A giant atypical neurofibroma in the right thoracic cavity of a 57-year-old man: a case report with review of the literature. North American Journal of Medicine and Science. 2009;2(4):135-6.

• Guo RJ, Funakoshi S, Lee HH, Kong J, and Lynch JP. The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting beta-catenin/TCF protein complex. Carcinogenesis. 2010;31(2):159-66. [16869] CLM RGCV 1219

2130 W. Central Ave., Suite 300 Toledo, OH 43606 T 419.534.3500 F 419.534.2608 www.auroradx.com