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Graduate Studies The Vault: Electronic Theses and Dissertations

2014-02-05 Expression Study Of Mycobacterium avium subspecies paratuberculosis Infected Cows – “A road to identify transcripts that could serve as biomarkers for early diagnosis of Johne’s disease”

David, Joel

David, J. (2014). Study Of Mycobacterium avium subspecies paratuberculosis Infected Cows – “A road to identify transcripts that could serve as biomarkers for early diagnosis of Johne’s disease” (Unpublished master's thesis). University of Calgary, Calgary, AB. doi:10.11575/PRISM/26265 http://hdl.handle.net/11023/1368 master thesis

University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. Downloaded from PRISM: https://prism.ucalgary.ca List of Upstream regulators associated with the differentially expressed © 2000-2013 Ingenuity Systems, Inc. All rights reserved. Upstream Regulator Molecule Type Predicted Activation State Activation z-score p-value of overlap Target molecules in dataset MYCN transcription regulator Activated 3.590 1.35E-02 CCNH,COL5A2,FGFR2,HDAC2,HSPD1,RPL13,RPL18A,RPL19,RPL21,RPL28,RPL29,RPL35,RPLP0,RPS12,RPS15,RPS19,RPS2,RPS3,SLIT3,TGM2,WAC,ZYX benzyloxycarbonyl-Leu-Leu-Leu aldehyde chemical - protease inhibitor Activated 2.163 3.10E-02 ABL1,ATP1A1,BIRC3,CFLAR,CHUK,CLU,CYP1A1,ESR1,HSF2,HSF4,HSP90AA1,HSPD1,MAPK6,NR3C1,PDGFRA,PPARA,PRDM1,RB1,RHOBTB2,RPLP0,SMAD2,STAT2 metribolone chemical reagent Activated 2.120 4.42E-02 ACSL3,ACTN1,ITGA6,KLK1,NEDD4L,NOS3,PFKFB2,PGM3,RDH11,SCAP,SMS,TACC2,UGDH INSR kinase Activated 2.355 5.02E-02 ACADM,ACOT13,ANP32A,ARHGDIA,CCNG2,CRY1,ETFA,FBP1,FH,GMCL1,HSD17B4,HSPD1,IDH3A,ITGA5,MCM5,NOS3,NPPA,PFDN6,PPARA,PSPC1,RAB18,RNF103,RWDD4,SIRT1,TGIF1,TOMM40 carbon tetrachloride chemical toxicant Activated 2.040 5.67E-02 COL3A1,FGFR4,GCLC,HDGF,HSP90AA1,HSPD1,IGF2R,MAPK14,PDGFRA,PPARD,PTP4A1,RB1,S1PR2,SKIL,SLC8A1,SMAD2,TIMP1 benzo(a)pyrene chemical toxicant Activated 2.132 1.46E-01 AGTPBP1,ALG2,ARHGDIA,CAMLG,CYP1A1,FGFR3,GCLC,GNAO1,HDAC2,LDB1,MAD2L1,NOS3,PSENEN,SOD3,TAF6,ZWINT VEGFA growth factor Activated 2.010 1.63E-01 ACADM,ANP32A,ARG2,ATP5G2,BCL6B,ETFA,LDB1,NOS3,PLAT,PPA1,PTGS1,SET,SLC25A17,TOMM20,TOMM22,TOMM70A dihydrotestosterone chemical - endogenous mammalian Activated 2.181 1.90E-01 ADRB3,CDK2,CLIC6,COL3A1,COL5A2,DDX5,ESR1,GLRX3,GOSR1,Hmgn1,HSP90AA1,KLK1,LIPE,MCM5,NOS3,NR3C1,PPARA,RAB2A,RAD21,RARRES2,RB1,ROM1,RPL19,RPL28,RPS12,SOD3,SQLE,SRD5A1,TACC2,TGM2,UGDH dexamethasone chemical drug Activated 2.258 3.67E-01 ACADM,ADAM10,ADHFE1,ADRB3,AMIGO2,ARG2,ARHGDIA,ARMC8,ATP1A1,AXIN2,BCLAF1,BIRC3,BMP1,C3orf37,CAMP,CBR3,CCNG2,CDCA7L,CDK2,CEP70,CES2,CFLAR,CHGA,COL10A1,COL11A1,COL4A2,CSN2,CYP1A1,DRD5,EGLN3,ETFA,FDX1,FILIP1L,GCLC,GHRL,HDAC2,HMGB1,HSD11B2,IFNGR2,IFRD1,IL17A,IL17RB,IL4R,IL7,IP6K3,ITGA5,KRT8,LAGE3,LAMB2,LIPE,LMO4,LTA,MUT,NET1,NPPA,NPPC,NPY2R,NR3C1,NUP50,OSBPL1A,PDCD1,PLAT,PNRC2,PPA1,PPARA,PPARD,PRKAR1A,PTGS1,RACGAP1,RB1,RCN2,RPLP0,SEC22B,SERPINA3,SFTPA1,SLC46A1,SNAPC1,SRSF11,SSTR2,ST6GAL1,STK38,TAF6,TERF1,TGM2,TIMP1,TSN,VARS,ZNF189 MYOD1 transcription regulator Activated 2.606 5.39E-01 CDK2,ESR1,HDAC11,ITGA7,PRKAR1A,RB1,SLC12A2,STAM,STAM2,ZNF238 H89 chemical - kinase inhibitor Activated 2.213 1.00E00 ABCA1,ADSS,CHGA,NR4A2,PPARD E. coli B4 lipopolysaccharide chemical toxicant Activated 2.170 1.00E00 C12orf49,CSF3,ELF1,ESR1,EXOC6,IL17A,PDCD1,PPARA,SIKE1,TRAF5 CXCL12 cytokine Activated 2.000 1.00E00 BMP1,CDK2,ERCC1,GSR,IFNGR2,NCK1,STRAP,TDG miR-590-3p (miRNAs w/seed AAUUUUA) mature microRNA Inhibited -4.559 9.64E-09 AGPAT5,AKAP5,ALG13,ALPK3,ANKRD40,APBB2,ARHGAP5,ATXN2L,AXIN2,AZIN1,BCAP29,BCL10,C11orf58,C12orf49,C5orf30,CAMKK1,CCDC149,CCNY,CDC73,CEP70,CLSTN1,COL5A2,COQ10A,CREBZF,CUL3,CUL5,CYLD,DARS,DCP1A,DDHD1,DENR,DR1,EID1,ESR1,FAM208A,FNBP4,G2E3,GATC,H2AFV,HDAC2,HDGF,IMPAD1,INSIG2,IP6K3,ITGA6,KIAA1715,KIAA2026,KLHL5,KPNA3,LAMP2,LATS1,MAPK6,MARCH5,MCTS1,MRPL44,MRPS25,NAA50,NAB2,NCK1,NDFIP2,NFIB,NMD3,NOL8,NR3C1,NR4A2,OLA1,OSMR,PDZK1,PFKFB2,PHAX,PHF1,PLAA,POLK,PPA1,PPM1B,PPP1R15B,PTGS1,PTP4A1,PTPN11,RAB12,RAB2A,RAD21,RAD23B,RBM12B,RCHY1,REEP5,RETSAT,RICTOR,RNF130,RNF7,RYBP,SAV1,SEL1L3,SERP1,SLC8A1,SMAD2,SPAG9,SPTLC1,SRSF1,STAM2,STRADA,STX17,SYNCRIP,TBC1D7,TM9SF1,TMED7,TMEM242,TMEM251,TSHZ2,UBE2I,UFL1,UGDH,VAMP4,VPS36,WAC,WASL,YAF2,ZNF146,ZNF238 miR-340-5p (miRNAs w/seed UAUAAAG) mature microRNA Inhibited -6.304 6.79E-07 ABAT,ABCA1,ACOX1,ADPGK,AGPAT2,AGPAT5,ANKIB1,ANKRD40,ANP32E,ARHGAP5,ARMC8,ATAD1,ATF1,ATG4C,BCL10,C1orf43,C2CD5,C8orf37,CACNB4,CADM3,CASD1,CCNG2,CDC73,CEP350,CEP70,CHUK,CLINT1,COQ10A,CREBZF,CRNKL1,CYLD,CYP4V2,DCUN1D5,DDHD1,DDX5,DHX40,DNAJB6,DR1,DRD1,EIF3J,FAM13B,FAR1,FBXO3,FDX1,FGFR4,G2E3,GLIS2,GNPDA2,GOSR1,H1F0,HLTF,HMGB1,HOXB2,IGF2BP3,IMPAD1,ITGA6,IVNS1ABP,KCNQ3,KIAA1432,KPNA3,MARCH2,MCMBP,MED17,MEMO1,MZT1,NDFIP2,NET1,NFIB,NR3C1,NR4A2,NUDT11,NUPL1,ODZ3,OTUD4,PDGFRA,PLAT,POLK,PPM1B,PRPF40B,PRRC1,PTP4A1,PTPN5,RAB11A,RAB27B,RB1CC1,RCN2,RNF7,RWDD4,RYBP,SAP30L,SBDS,SEC23IP,SELT,SLC12A2,SLC30A6,SLC33A1,SLC38A3,SMAD2,SMARCAD1,SMOC1,SMURF1,SPAG9,STAM2,STIM2,STX7,SYNCRIP,TERF1,TMED7,TMEM64,TMOD1,TOMM40,TOPORS,TSEN15,TSHZ2,UBE2E3,UGDH,VAMP4,VGLL4,VPS37A,WDR43,WDR76,WNT11,XPOT,YAF2 miR-19b-3p (and other miRNAs w/seed GUGCAAA) mature microRNA Inhibited -2.477 2.50E-05 ABCA1,ACBD5,ACSL3,ACTN1,ADSS,AGPAT5,ALG13,ALG2,ANKIB1,ARHGAP5,ARIH2,ARMC8,BAG5,BTBD7,BTF3L4,C14orf129,C2CD5,C5orf30,CAND1,CARD10,CDC73,CEP350,CLIP1,CREBZF,CUL5,CYLD,DDHD1,DHX40,EMX2,ESR1,FKBP15,G2E3,GIGYF1,GLIS2,GRSF1,IGF2R,INSIG2,IREB2,ITGA6,IVNS1ABP,KIAA1468,KIAA2026,KPNA3,LGALSL,MAP3K12,MAPK14,MAPK6,MARK2,MEMO1,MFSD6,MTMR6,NDFIP2,NFIB,NR4A2,NUP54,PATL1,PHAX,PHF12,PLAA,PNRC1,PPARA,PPP1R15B,PRC1,PTGES3,PTP4A1,RAB18,RACGAP1,RAD23B,RGL1,RIC3,RICTOR,RNF11,RNF19A,RYBP,S1PR2,SCN1B,SEC22B,SEL1L3,SLC8A1,SMOC1,SMURF1,STAM2,STAT2,STK38,SV2A,SYNCRIP,TGIF1,TGM2,TMEM63B,TMEM64,TNRC6A,UBE2D2,USP33,USP8,VGLL4,VPS37A,WAC,WHSC1L1,YAF2,ZER1,ZNF238 chromium chemical drug Inhibited -2.728 7.14E-05 AGTPBP1,ALG2,ARHGDIA,CAMLG,CYP1A1,ESR1,GCLC,PSENEN,SOD3,TAF6,ZWINT miR-203-3p (and other miRNAs w/seed UGAAAUG) mature microRNA Inhibited -3.443 5.21E-04 ABL1,ACSL3,ADAMTS8,ADPGK,AMFR,ANP32A,ANP32E,APBB2,BAHD1,BTBD7,C14orf129,C1orf122,CASC4,CCNG2,CCNY,CREBZF,CSN2,DCP1A,DCUN1D5,DR1,ESR1,FAM208A,FASTKD2,FKBP7,FUBP3,GATC,GOSR1,GRSF1,IGF2R,IVNS1ABP,KHDRBS1,LAMP2,LGALSL,LMO4,MAGI1,MATR3,N4BP3,NAA30,NAA50,NEDD4L,NFIB,NSL1,OSBPL1A,PARP16,PDGFRA,PHF12,PLAA,PPP1CB,PTGS1,PTP4A1,PTPN1,RAB27B,RAVER2,RCN2,RWDD4,SAV1,SELT,SLC12A2,SLC30A6,SLMO2,SMURF1,SPATA5,SRSF1,SRSF3,SYNCRIP,TMEM242,TSHZ2,UBE2I,VGLL4,VPS37A,WAC,ZNF281,ZNF608 miR-137-3p (and other miRNAs w/seed UAUUGCU) mature microRNA Inhibited -2.025 7.46E-04 ADO,ALPK3,ARHGAP5,AXIN1,AZIN1,BCORL1,BMP7,CACFD1,CACNA1H,CCNG2,CCNY,CDC37L1,CDCA7L,CHGA,CNN2,CNST,CSNK1G3,CTDSPL,CUL3,DCP1A,DHX40,DR1,DUS2L,ERBB2IP,FAM20C,FBXL7,GIGYF1,GLIS2,GLRX3,GPR88,GPRC5A,HCRT,HLTF,HNRPDL,IBTK,ITGA5,JPH2,KIAA1432,KIF3B,MAPKAPK2,MARCH9,MCTS1,MXRA7,NAB2,NCK1,NCOA2,NECAP1,NFIB,NR3C1,PDGFRA,PIAS2,PLXNB2,PPP1CB,PRDM1,PRKD3,PTP4A3,PTPN5,RAB11A,RAVER2,RICTOR,RPL28,RWDD4,SCN1B,SELT,SERP1,SERPINA3,SGOL1,SLC12A2,SLC8A1,SMURF1,SNAPC1,SPTLC1,SSR1,ST13,STK3,STK38,STX17,SV2A,SYNCRIP,TBC1D1,TBCE,TMX1,TSN,USP38,VARS,VMA21,VPS36,VPS37A,ZMYM5,ZNF238,ZNF326 miR-130a-3p (and other miRNAs w/seed AGUGCAA) mature microRNA Inhibited -3.381 8.77E-04 ABCA1,ACBD5,ALDH3A2,ALG13,ANKIB1,BAG5,BAHD1,BTBD7,BTF3L4,C5orf30,CASD1,CCNY,CDC73,CEP120,CHMP3,CLIP1,CMPK1,CUL3,CYLD,EGLN3,EMX2,ERBB2IP,ESR1,FAM35A,FAM45A,HABP4,KIAA1468,LGALSL,MAGI1,MAP3K12,MEMO1,MFSD6,MTMR6,N4BP1,NAA30,NAA50,NEDD4L,NFIB,NIPA2,PANK3,PDGFRA,PHAX,PHF12,PLAA,PLEKHF2,PNRC1,PPP1R15B,PRKD3,PTGES3,PTP4A1,RACGAP1,RASAL1,S1PR2,SCML4,SEL1L3,SLC8A1,SMOC1,SNX5,SRSF2,STIM2,STX7,SYNCRIP,TMEM63B,TMOD1,TNRC6A,UBE2D2,UBE3B,USP33,USP8,UXS1,VGLL4,VPS37A,WASL,WHSC1L1,ZNF238,ZNF800 miR-124-3p (and other miRNAs w/seed AAGGCAC) mature microRNA Inhibited -2.654 1.06E-03 ABCA1,ADI1,AGPAT5,ALG2,ANKIB1,ANKLE2,AP1M2,APBB2,ARHGDIA,ARRDC1,ATAD1,ATP1A1,AXIN1,BAHD1,BLOC1S6,BTBD7,C12orf23,CACFD1,CACNB4,CAPNS1,CASC4,CCNY,CDC73,CDCA7L,CDK2,CEP350,CLIC6,CLMN,CMPK1,CMTM4,CPNE3,CSDE1,CTDSPL,CUL5,DCP1A,DCUN1D2,DCUN1D5,DGAT2,FAM174B,FAM210A,FAM35A,FAR1,FARP1,FGFR1OP,FKBP15,FRMD8,GALNT12,GLIS2,GMCL1,GNPDA2,GRSF1,IMPAD1,INSIG2,ITGA7,KATNA1,KCNQ3,KIAA1468,KIAA1715,KPNA3,LIPE,LMO4,MAP3K3,MAPK14,MTMR6,MYCBP,MYLK2,N4BP1,NAP1L5,NFIB,NR3C1,NUPL1,OSBPL11,OTUD4,PARP16,PDXK,PLEKHF2,PLXNB2,PNN,POC1B,PPARA,PRR3,PRRC1,PTPN1,PTPN11,RAB11A,RAB11FIP5,RAB2A,RAVER2,RB1CC1,REEP2,RNF19A,RWDD4,RYBP,SAP30L,SCML4,SDAD1,SERP1,SGPP1,SLC12A2,SLC33A1,SLC35F5,SLC6A2,SMARCAD1,SPAG9,SPTLC1,SSR1,STK36,STK38,STX17,SUCLG2,SYNCRIP,TACC2,TBC1D1,TBC1D20,TDG,TMEM168,TMOD1,TRABD,TSHZ2,TSN,UBE2O,USP38,VAMP4,WDR81,WIPF2,ZBTB7C,ZNF189,ZNF608,ZWINT miR-26a-5p (and other miRNAs w/seed UCAAGUA) mature microRNA Inhibited -5.048 1.13E-03 ABCA1,ACBD5,ACSL3,AGPAT5,ANKIB1,BTBD7,C2CD5,CACNB4,CCDC28A,CCNE2,CDK8,CEP350,CHAC1,CMTM4,COL10A1,COL11A1,COL22A1,CREBZF,ESR1,FAM208A,FAM45A,FGD1,FPGT,G2E3,GRSF1,GSR,IMPAD1,ITGA5,ITGA6,KIAA1468,KPNA3,MAPK6,MATR3,MFAP3,MFSD6,MYCBP,NAP1L5,NUDT11,NUP50,OSBPL11,OTUD4,PFKFB2,PHAX,PPM1B,PPP1R15B,PRDX3,PTP4A1,RAB11A,RB1,RBM12B,RCN1,RCN2,RDH14,SCML4,SERP1,SLC12A2,SLC33A1,SLC35A3,SMAD2,SRSF3,TANK,TMEM64,TMEM68,TNRC6A,USP3,VGLL4,VMA21,WIPF2,XPR1,YAF2,ZNF238,ZNF462,ZNF608 miR-23a-3p (and other miRNAs w/seed UCACAUU) mature microRNA Inhibited -3.136 1.24E-03 ABCA1,ALG6,ARHGAP5,B3GNT1,BCLAF1,BTBD7,C12orf23,C12orf49,CADM3,CASD1,CDC40,CEP350,CHUK,CLDN12,CNN2,CNNM1,CREBZF,CRLF3,CSNK1G3,CSNK2A2,CTDSPL,CUL3,CYBRD1,DCUN1D5,DDX5,DLD,ERBB2IP,FAM208A,FGFR3,FKBP7,GALNT12,GNPDA1,ISCA2,KLHL5,KPNA3,MAGI1,MAP3K3,MYCBP,N4BP1,NAA50,NAP1L5,NCOA6,NDFIP2,NEDD4L,NFIB,NUP50,OLA1,OTUD4,PCMTD2,PLEKHF2,PNRC1,PNRC2,PPP1CB,PRDM1,PRDX3,PRKD3,PTGR2,PTPN11,RAD23B,RBM12B,RCHY1,RCN1,RNF219,SEC23IP,SET,SLC12A2,SLC6A2,SMS,SNX5,STARD3NL,STX17,SV2A,SYNGAP1,TGIF1,TMED7,TMEM101,TMEM64,TMEM68,TMOD1,TNRC6A,TPST1,UBA6,UBE2O,USP5,WAC,WASL,WBP4,WIPF2,YWHAG,ZNF238,ZNF572 miR-381-3p (and other miRNAs w/seed AUACAAG) mature microRNA Inhibited -2.994 1.35E-03 ACBD5,ACSL3,ARHGAP5,ARMC8,AZIN1,BTBD7,BTF3L4,C11orf58,CASD1,CCNY,CDC73,CMTM4,CNBP,COL11A1,CREBZF,CUL3,CUL5,DCUN1D5,DHX40,ESR1,FAM208A,FGF1,FGFR2,FILIP1L,FNBP4,HMGB1,IREB2,ITGA6,KCNQ3,KHDRBS1,KPNA3,LMO4,MAGI1,MAPRE2,MAVS,MYCBP,NAP1L5,NASP,NFIB,NOC3L,NR3C1,NR4A2,PAPOLA,PATL1,PNN,PNRC1,PPP1CB,PTP4A1,RAB2A,RBM12B,RICTOR,RNF19A,RNF40,RRN3,RYBP,SMARCAD1,SMOC1,SNRNP40,SPPL3,SRSF1,SYNCRIP,TMED7,TMEM168,TMEM68,TNRC6A,TSHZ2,VPS37A,WAC,XPO1,XPR1,ZMYM6,ZNF238 miR-3935 (miRNAs w/seed GUAGAUA) mature microRNA Inhibited -2.401 1.41E-03 DNAJC10,MAPK6,RAPGEF6,RNF115,SLC35A3,SNX5 miR-292-5p (and other miRNAs w/seed CUCAAAC) mature microRNA Inhibited -2.858 1.50E-03 ACSL3,AXIN2,BAG5,BAHD1,BCLAF1,BCORL1,BTF3L4,C11orf58,CCNY,CDC73,CUL3,CYBRD1,CYLD,DCP1A,FLI1,IMPAD1,KIF3B,MCTS1,MIOS,NAA50,PRUNE,RAB11A,RAD23B,SAE1,SET,SIKE1,SLC35F2,SPAG9,SPRYD7,SRSF3,SSR1,TSEN15,TSHZ2,USP33,XPO1,YAF2 miR-421-3p (and other miRNAs w/seed UCAACAG) mature microRNA Inhibited -2.211 1.53E-03 ABAT,ACSL3,APBB2,ARHGAP5,ARMC8,BCLAF1,BLOC1S6,C2CD5,CACNB4,CASD1,CMTM4,CREBZF,CSNK2A2,CUL3,DMBT1,EIF2S2,FAR1,HNRPDL,IREB2,KIAA2026,MARCH5,MCMBP,MED4,MFSD6,NAA50,NFIB,PDGFRA,PFKFB2,PIPOX,POLR1B,POLR2D,RIC3,SAP30L,SMARCAD1,SRSF1,SSR1,STAM2,TBC1D22A,TOMM20,TOMM70A,TSN,UBE2O,WAC miR-1 (and other miRNAs w/seed GGAAUGU) mature microRNA Inhibited -2.447 1.65E-03 ABCA1,ADPGK,ANKIB1,ANP32E,ARG2,AZIN1,C12orf49,C2CD5,C3orf45,CAND1,CASKIN2,CCDC149,DDX5,ESR1,FPGT,FUBP3,G2E3,GCLC,GDF6,GLIS2,GNPDA2,GOSR1,HSPD1,KDM5C,KIF3B,KLHL5,LAMP2,MATR3,MBLAC2,MLL5,NAP1L5,NDFIP2,NEDD4L,NET1,NR3C1,NR4A2,NUP50,PAX8,PEX2,PFKFB2,PHAX,PRRC1,PTPN1,RIC3,RICTOR,RNF40,RYBP,SEC22B,SEC23IP,SELT,SEPT2,SERP1,SLC38A3,SLC8A1,SMAD2,SMARCA4,SRSF1,SRSF3,SRXN1,SYNCRIP,TMEM178A,TMX1,TOMM70A,TPM4,USP33,VAMP4,VGLL4,VPS45,WASL,WIPF2,XPO6,ZNF146,ZZZ3 miR-495-3p (and other miRNAs w/seed AACAAAC) mature microRNA Inhibited -3.647 1.75E-03 AGPAT5,ANKRD40,ARHGAP5,ARMC8,ATG4C,BCAP29,BCLAF1,BCORL1,BMP7,BTF3L4,C11orf58,C17orf75,CDC73,CEP350,CFLAR,CLMN,CNBP,CREBZF,CYLD,DCAF6,DDHD2,DHX40,EID1,EMX2,EPB41L2,FGFR1OP,HMGB1,HSP90AA1,IP6K3,IREB2,KIAA1033,KLHL5,MANEA,MBLAC2,MCMBP,MYCBP,NAB2,NDFIP2,NEDD4L,NFIB,OTUD4,PHF1,PNRC1,PPP1CB,PRKAR1A,PRUNE,PTP4A1,RAB2A,RAPGEF6,RHEB,RICTOR,RYBP,SEC23IP,SET,SGCE,SLC12A2,SLC8A1,SLMO2,SMOC1,SMURF1,SPG11,SPPL3,SPRYD7,SRSF1,SSR1,STX7,TMEM101,TNRC6A,TRIM13,TSHZ2,VGLL4,ZNF238,ZNF281 miR-144-3p (miRNAs w/seed ACAGUAU) mature microRNA Inhibited -3.784 1.96E-03 ABCA1,ARHGAP5,ATP5G2,AXIN2,C11orf58,CCNE2,CCNG2,CDC73,CEP350,COL10A1,COL5A2,CREBZF,CRTC1,CUL3,CUL5,DDHD1,FKBP7,FLI1,FPGT,FUBP3,GCLC,GRSF1,H2AFV,HSF2,IGF2R,KIAA1033,KPNA3,LRPPRC,MAPK6,MED4,MFSD6,MLL5,NET1,NFIB,NR3C1,NUDT11,ODZ3,OLA1,PANK3,PAX8,PFDN6,PGGT1B,PLAT,PNRC1,PPARA,PRKD3,PTP4A1,RAB2A,RBM43,RGL1,RGS14,SAP30L,SELT,SENP7,SLC12A2,SLC25A15,SLC35A3,SMARCA4,SOBP,STAM,STAMBP,SYNCRIP,SYNGAP1,TDG,TGIF1,TNRC6A,TSHZ2,UBE2D2,USP38,YLPM1,YWHAG,ZNF238,ZNF800 miR-539-5p (miRNAs w/seed GAGAAAU) mature microRNA Inhibited -3.716 2.73E-03 AKAP5,AXIN1,BTBD7,C11orf58,CDCA7L,CLIC6,CMTM4,DCP1A,DDHD1,DDX5,ESR1,ETAA1,FAM208A,FBXL7,FNBP4,GCNT1,KDM5C,KPNA3,LATS1,MANEA,MAP3K12,MAPRE2,MARK2,MAVS,MFAP3,N4BP1,NECAP1,NFIB,NR4A2,ODZ3,PAPOLA,PARP16,PFKFB2,PHAX,PISD,PPARA,PPP1CB,RAB11A,RIC3,RRAGB,RWDD4,SEC23IP,SMARCAD1,SMURF1,SPAG9,STAMBP,SYNGAP1,TMED7,TMEM64,TMX1,TOMM20,TSHZ2,UBA6,VAMP4,VPS36,WBP4,XPO6,XPR1 miR-145-5p (and other miRNAs w/seed UCCAGUU) mature microRNA Inhibited -2.185 2.90E-03 ABCA1,ADPGK,ADRB3,ARHGAP5,ATF1,BLOC1S6,BNIP3,BTF3L4,C11orf58,C5orf15,CABP4,CAMKK1,CCNG2,CDC37L1,CLINT1,CLIP1,CLMN,CRTC1,CSN2,CUL5,DDR1,DFFA,EIF3J,FAM108B1,FAM174B,FLI1,FZD9,GIGYF1,HABP4,HLTF,IFNGR2,IVNS1ABP,KIAA1715,LAMP2,LDB1,LPIN2,MAP3K3,NAA30,NAA50,NDFIP2,NEDD4L,NET1,NFIB,NR4A2,PGM3,PHRF1,PRKD3,PTGR2,SAP30L,SIKE1,SLC38A11,SMAD2,STAM,STIM2,TMEM178A,TMEM63B,TMOD1,TPM4,TSHZ2,UBA6,UXS1,VAMP4,VGLL4,VSTM4,YWHAG miR-101-3p (and other miRNAs w/seed ACAGUAC) mature microRNA Inhibited -3.168 3.83E-03 ABCA1,ATP5G2,AXIN2,BLOC1S6,CCNG2,CDK8,CEP350,COL10A1,CREBZF,CSRP2,CUL3,CUL5,DDHD1,DR1,ERBB2IP,FAM108B1,FGFR3,FKBP7,FLI1,GCLC,GRSF1,GSR,H2AFV,ICOS,IGF2R,KIAA1432,KPNA3,MAGI1,MAPK6,MFSD6,N4BP1,NFIB,NUDT11,ODZ3,OTUD4,PANK3,PAX8,PLAT,PNRC1,PPARA,PRR3,RCN2,RGL1,RNF219,SAP30L,SELT,SLC12A2,SLC33A1,SLMO2,SMAD2,SMARCA4,SOBP,SPG11,STAMBP,STIM2,SYNCRIP,SYNGAP1,TDG,TGIF1,TMEM68,TSHZ2,UBE2D2,USP38,XPR1,YAF2,YLPM1,ZNF238 miR-200b-3p (and other miRNAs w/seed AAUACUG) mature microRNA Inhibited -2.433 5.07E-03 ABAT,ABCA1,AMFR,ARHGDIA,ARIH2,B3GNT1,BAG5,BTF3L4,CASC4,CASD1,CCNE2,CDC73,CDK2,CEP350,CLIP1,CNST,COPS8,CSNK1G3,CUL5,ERBB2IP,FARP1,FGD1,FLI1,FNBP4,FUBP3,G2E3,GDF6,GIGYF1,GLIS2,GNPDA1,IGF2R,IMPAD1,INTS8,KCNQ3,KIAA1432,LIN7B,LMO4,LPIN2,MATR3,MBLAC2,MLL5,MRPS25,NAP1L5,NCOA2,NEDD4L,NFIB,NR3C1,OSBPL11,OSMR,PISD,POLK,PPM1B,PPP1CB,PPP4R2,PRDM1,PRKAR1A,PRR3,PTP4A1,PTPN11,RAB18,RAVER2,RBM12B,RELN,RGL1,SGCE,SIKE1,SMAD2,SMARCAD1,SMURF1,SNAPC1,SPAG9,SRSF1,SRSF2,SYNCRIP,TMBIM4,TMEM178A,TTC33,TTC5,UBA6,UBE2I,YWHAG miR-141-3p (and other miRNAs w/seed AACACUG) mature microRNA Inhibited -2.450 5.37E-03 ANKLE2,ANP32E,APBB2,BAHD1,BCAP29,CASC4,CCNE2,CEP120,CNBP,CNP,CRLF3,CSF3,CSNK1G3,CUL3,DDX5,DR1,ERBB2IP,FAM210A,GDF6,GIGYF1,HMGCS1,IFNAR1,ITGA6,KCTD20,KIAA1430,KIAA1715,KPNA3,LGALSL,LPIN2,MAP3K3,MAPRE2,NAA50,NDFIP2,NR3C1,ODZ3,OSBPL11,PANK3,PIGW,PLCB4,PPARA,PPP1R15B,PRKAR1A,PTP4A1,RAB38,RAD23B,RANBP6,RHEB,RNF185,RWDD4,RYBP,SIRT1,SOBP,SPAG9,SYNCRIP,UBA6,WDR43,WDR81,YAF2,YWHAG,ZCCHC3,ZNF238,ZSCAN29 miR-935 (miRNAs w/seed CAGUUAC) mature microRNA Inhibited -2.412 5.92E-03 C12orf23,CSNK1G3,IREB2,MBLAC2,RELN,SLC12A2 miR-217-5p (and other miRNAs w/seed ACUGCAU) mature microRNA Inhibited -2.182 7.09E-03 ACOX1,ADSS,AKAP10,ATF1,CREBZF,CSGALNACT2,CUL5,FGFR2,GRSF1,INSIG2,KATNA1,KIAA2026,MED17,NR4A2,NUPL1,PANK3,PNRC2,PPARA,PPP1CB,PPP4R2,PTP4A1,RAD23B,RAPGEF6,REEP5,RICTOR,SEC23IP,SENP7,SIRT1,TACC2,TDG,TMEM178A,TMEM68,TOPORS,TRIM13,USP38,YAF2,YWHAG miR-30c-5p (and other miRNAs w/seed GUAAACA) mature microRNA Inhibited -3.713 7.43E-03 ABL1,ACTN1,ADO,ADPGK,AKAP10,ALPK3,ATF1,AZIN1,BAHD1,BMP7,BTBD7,C14orf129,C1orf174,CCNE2,CCNY,CDC37L1,CEP350,CMTM4,CYLD,DCP1A,DHX40,GCLC,GIGYF1,GNAO1,GNPDA1,IFRD1,IGF2R,INSIG2,IP6K3,ITGA5,ITGA6,KCTD3,KIAA1033,KIAA1715,KIAA2026,KPNA3,LRRC8D,LYST,MAP3K12,MATR3,MCTS1,MFSD6,MPL,MRPS25,MZT1,NECAP1,NEDD4L,NFIB,NR3C1,NR4A2,ODZ3,PAAF1,PAPOLA,PARP16,PCMTD2,PDP2,PGGT1B,PGM3,PLCB4,PNN,PPIP5K2,PRDM1,PRKAR1A,PTP4A1,RAB11A,RAB27B,RAB38,RAD23B,RASL12,RAVER2,RGL1,RNF7,RWDD4,SDAD1,SEC23IP,SEL1L3,SIRT1,SMAD2,SOBP,SPAG9,STIM2,STX17,STX7,SUCLG2,SYNCRIP,TANK,TASP1,TDG,TMED7,TNRC6A,TPM4,UBE2D2,UBE2I,UBE2O,VSTM4,XPO1,XPR1,YAF2,ZNF200,ZNF238,ZNF608,ZSCAN29 miR-3120 (and other miRNAs w/seed ACAGCAA) mature microRNA Inhibited -2.318 8.48E-03 APBB2,COL10A1,DDX20,EID1,ERBB2IP,HMGB1,KIAA1143,MRPL44,PPM1B,PRKAR1A,WASL,ZNF567,ZNF608 miR-9-5p (and other miRNAs w/seed CUUUGGU) mature microRNA Inhibited -3.331 8.83E-03 ABAT,ABCA1,ADAM10,ADPGK,ALG6,ANKRD40,ARHGDIA,ATF1,BAHD1,BCLAF1,BTBD7,C11orf58,C14orf129,C5orf30,CCNE2,CD46,CDC73,CEP350,CLMN,CNNM1,CNP,COG6,COL4A2,CREBZF,DCP1A,DDHD2,DHX40,DONSON,DR1,DSE,EGLN3,ERBB2IP,FARP1,FKBP7,FTSJD1,GALNTL1,GIGYF1,GOSR1,GRSF1,HLTF,HSP90AA1,ICA1,IGF2BP3,IGF2R,IMPAD1,ITGA6,KIAA1468,LGALSL,MAGI1,MAP3K3,MAPKAPK2,MCMBP,MTHFD1L,MYCBP,MYPN,NFIB,NPY2R,OSBPL11,PALMD,PANK3,PDZK1,PPARA,PPARD,PPIP5K2,PRC1,PRDM1,PRKD3,PRUNE,RAB27B,RNF11,RNF19A,RYBP,SAP30L,SEC23IP,SIRT1,SLC33A1,SLC6A2,SLC8A1,SMURF1,SNAP23,SPAG9,SRSF1,STAM,STK3,TBC1D22A,TOMM20,TRAM1,TSHZ2,VGLL4,ZBTB1 miR-181a-5p (and other miRNAs w/seed ACAUUCA) mature microRNA Inhibited -3.710 9.10E-03 ADO,ANP32A,AP1AR,BCLAF1,BLOC1S6,C14orf129,C2CD5,C7orf41,CAMKK1,CASC4,CDC73,CDK8,CEP350,CHMP3,CLIP1,CLMN,CREBZF,CSNK1G3,CTDSPL,CUL3,CUL5,CYLD,DCP1A,DDX5,EMX2,EPB49,ESR1,FAM13B,FAM3C,FAR1,FGFR3,FNBP4,GALNTL1,GATC,GIGYF1,GNAO1,IGF2BP3,ITGA6,KIAA1715,KIF3B,KLHL5,L1CAM,LGALSL,LRRC8D,MAP3K3,MBLAC2,MFSD6,MYCBP,NAA50,NAP1L5,NCOA2,NFIB,NOL8,NR3C1,OTUD4,PANK3,PDGFRA,PNRC2,PPARA,PPIP5K2,PPM1B,PPP1CB,PRDM1,PTGR2,RAB11A,RAB27B,RAD21,RAD23B,RALA,RBM22,RBM26,SIRT1,SLC6A2,SMAD2,SPAG9,STIM2,TBC1D1,TMEM242,TMEM64,USP33,USP8,VGLL4,YLPM1,YWHAG,ZCCHC3,ZNF200,ZNF800,ZZZ3 miR-148b-3p (and other miRNAs w/seed CAGUGCA) mature microRNA Inhibited -3.293 9.77E-03 ABCA1,ALG13,ATP4B,ATP6AP2,C5orf30,CAND1,CDK8,CNN1,COL2A1,CUL5,DCP1A,DDHD2,EMX2,ESR1,GDF6,HDGF,ITGA5,KIAA1468,KLC2,KLHL5,MAGI1,MPL,MRPS25,MTMR6,OSBPL11,OTUD4,PATL1,PHAX,PLAA,PNRC2,PPARD,PPP1CB,PTGES3,PTGS1,RAB12,RASAL1,RICTOR,RNF219,SCAP,SELT,SMAD2,SMS,SOBP,SPRYD7,SRSF11,SSR1,SYNCRIP,TMED7,TMEM63B,TNRC6A,TOMM70A,TSPYL1,UBA6,UBE3B,USP33,VPS37A,WASL,ZNF238 miR-155-5p (miRNAs w/seed UAAUGCU) mature microRNA Inhibited -3.194 9.95E-03 AMIGO2,APBB2,BAG5,BCL10,BCORL1,CDC73,CTLA4,DCUN1D2,DHX40,FAR1,G2E3,GCNT1,GDF6,GRSF1,HERC4,KCTD3,KIAA1715,LAMP2,MARK2,MATR3,MFAP3,N4BP1,NAA50,ODZ3,PRKAR1A,RAB27B,RCN2,RGL1,RHEB,RICTOR,RNF123,RRAGB,SAP30L,SIRT1,SLC33A1,SLC35F5,SMAD2,SMARCA4,SMARCAD1,TERF1,TOMM20,TRAM1,UFL1,USP8,VMA21,ZNF238 miR-543-3p (and other miRNAs w/seed AACAUUC) mature microRNA Inhibited -3.026 1.03E-02 ACOX1,AKAP5,ANKRD40,ARMC8,ATF1,C12orf23,C5orf30,CACNB4,CASKIN2,CEP350,CLMN,CTDSPL,CUL3,CYLD,DCAF17,DCP1A,DGAT2,DNAJC10,FAM13B,FAM189B,FGFR2,GDF6,GNAO1,GORAB,HERC4,IREB2,KLHL5,LPIN2,LRRC8D,MAGI1,MARK2,MATR3,MRPS25,NFIB,NR3C1,PANK3,PPP1CB,PTGR2,PTP4A1,RAB11A,RAD21,RB1CC1,RBM26,RCHY1,SELT,SIRT1,SPAG9,STAM,TBC1D1,TMEM242,TSHZ2,TSPAN7,UBE2M,VSTM4,WASL,ZNF281,ZZZ3 miR-142-3p (miRNAs w/seed GUAGUGU) mature microRNA Inhibited -2.908 1.12E-02 ACBD5,ANKRD40,BCLAF1,BTBD7,CEP192,CHMP3,CLDN12,CUL5,FBXO3,GTF2A1,HMGB1,MZT1,NFIB,NR3C1,NUDT11,PLRG1,PPARA,RAB11A,RAB2A,RAB3A,RHEB,RICTOR,SH2B1,SLC35F5,STAM,STAM2,STX7,TPM4,WASL,WIPF2,XPO1,ZZZ3 miR-17-5p (and other miRNAs w/seed AAAGUGC) mature microRNA Inhibited -3.288 1.16E-02 ABCA1,ACBD5,ANKIB1,APBB2,BAHD1,BCL6B,BTBD7,C7orf41,CCNG2,CDC37L1,CDC40,CEP120,CIC,CMPK1,CMTM4,CNN1,CROT,CTDSPL,CUL3,CYBRD1,CYLD,DDHD1,DDX5,DNAJB6,DRD1,EGLN3,ESR1,FAM210A,FAM3C,FAM45A,FGD1,FTSJD1,GGCX,GIGYF1,GMCL1,GNPDA2,GOSR1,HABP4,KIF3B,KPNA3,LYST,MAP3K12,MAP3K3,MARK4,MED17,NAA30,NEDD4L,NFIB,NR4A2,PANK3,PAPOLA,PDGFRA,PHF1,PPARA,PPARD,PPP1R15B,RAB11FIP5,RAB12,RACGAP1,RAD23B,RANBP6,RASL12,RB1,RB1CC1,RGL1,RYBP,SEPT2,SERP1,SIKE1,SLC33A1,SMOC1,SMURF1,SOBP,SPATA5,STK38,SYNCRIP,TBC1D20,TMEM168,TMEM64,TNRC6A,TOPORS,TSHZ2,USP3,UXS1,WAC,WIPF2,ZNF238,ZNF800,ZNFX1 miR-377-3p (miRNAs w/seed UCACACA) mature microRNA Inhibited -2.120 1.31E-02 AGPAT5,AKAP5,ARMC8,AXIN1,AZIN1,BTBD7,C8orf37,CCNG2,CHUK,COQ10A,CREBZF,DARS2,DCP1A,EPB49,FAM208A,GOSR1,GRSF1,IREB2,IRX3,ITGA6,LRPPRC,MCTS1,MYCBP,NAP1L5,NCOA6,NFIB,NR3C1,NT5C3L,ODZ3,PCF11,PCMTD2,PDGFRA,PDP1,PTGS1,RBM18,SEC23IP,SGOL1,SPPL3,SPTLC1,SRSF1,SV2A,TCOF1,TMED7,TMX1,TREML2,UBE2D2,UBE2O,YAF2,ZER1,ZNF462,ZZZ3 miR-194-5p (miRNAs w/seed GUAACAG) mature microRNA Inhibited -2.629 1.33E-02 AKAP5,ARHGAP5,BCLAF1,BTBD7,C12orf23,CEP350,CTDSPL,DCUN1D5,FGFR3,FLI1,GDF6,GIGYF1,GORAB,LPIN2,MAP3K3,MCTS1,NAA50,NSL1,PANK3,PGM3,PHF1,PRKAR1A,RAB38,RHEB,RYBP,SDAD1,SET,SGCE,SLC8A1,SMURF1,SPPL3,TMBIM4,TSPAN7 miR-4777-5p (miRNAs w/seed UCUAGAU) mature microRNA Inhibited -2.000 1.34E-02 BTBD7,COG6,MTMR6,NAA50 miR-135a-5p (and other miRNAs w/seed AUGGCUU) mature microRNA Inhibited -2.475 1.47E-02 ABAT,ACOX1,ADO,ANKRD40,ANP32E,BCAP29,BMPER,C7orf41,CADM3,CCNG2,CDC40,CEP350,CIC,CMTM3,CSNK1G3,DCP1A,FARP1,GCLC,KIAA1033,KIAA1432,KIF3B,KPNA3,LATS1,MAN1A1,MAP3K3,MAPRE2,MRPS25,NDFIP2,NET1,PATL1,PCMTD2,PDP1,PEX7,PGGT1B,PRKD3,PTPN1,RAPGEF6,RAVER2,RGL1,RICTOR,RYBP,SCML4,SEC22B,SIRT1,SLC30A6,SRSF3,SSR1,STAB2,STAMBP,SYNCRIP,SYNGAP1,TMEM168,TOPORS,TSHZ2,VGLL4,WAC,ZCCHC3 miR-186-5p (miRNAs w/seed AAAGAAU) mature microRNA Inhibited -2.611 1.54E-02 ACSL3,AGPAT5,APBB2,ARHGAP5,ARMC8,BAHD1,C2CD5,CAMLG,CD46,CDC73,CDK2,CREBZF,CUL3,CUL5,CYLD,DCP1A,DHX40,EIF2S2,FAR1,FASTKD2,FGFR3,FRMD8,G2E3,GOSR1,HOXB2,LAMP2,MAPK6,MAPKAPK5,MBLAC2,MFAP3,MTMR6,NASP,NCOA2,NFIB,NR4A2,OTUD4,PDP2,PGGT1B,PGM3,PPM1B,PPP1CB,PRDM1,PTGES3,PTPN11,RAB11A,RAB2A,RAD23B,RB1CC1,RBM26,RNF11,SLC12A2,SPATA5,SPRYD7,SYNCRIP,TERF1,TMEM242,TMOD1,TSPYL1,UNC45B,VPS37A,WAC,YAF2,ZNF608,ZZZ3 miR-147-5p (and other miRNAs w/seed GGAAACA) mature microRNA Inhibited -2.016 1.57E-02 GOSR1,KIAA1033,MATR3,PGM3,RBM18,SERP1,WAC miR-873-5p (and other miRNAs w/seed CAGGAAC) mature microRNA Inhibited -2.597 1.60E-02 ABAT,AGPAT5,ALG1,ARMC8,BMP7,COX6C,DDX5,EGLN3,FBXO3,GATC,GGACT,GRSF1,HDGF,KPNA3,MARK2,MATR3,MCMBP,NEDD4L,NFIB,PATL1,PHRF1,PPARA,SERP1,SMG6,SRSF11,SSR1,TACC2,TERF1,TSHZ2,YAF2,YIPF5,ZNF238 miR-183-5p (miRNAs w/seed AUGGCAC) mature microRNA Inhibited -2.092 1.68E-02 ABAT,ABCA1,AGAP3,AGPAT5,AMIGO2,CTDSPL,ERBB2IP,ICA1,KIF3B,MARK2,MFAP3,MFSD6,MTMR6,NARS2,NR3C1,NR4A2,OTUD4,PANK3,PLCB4,PPP2CB,RAB27B,RALA,RCN2,SERP1,SLC25A15,SOBP,SRSF11,SRSF2,STX7,TMED7,TOMM70A,TRIM5,VPS37A,XPOT,XPR1,YAF2 miR-490-3p (miRNAs w/seed AACCUGG) mature microRNA Inhibited -2.727 1.75E-02 ANKRD40,CACNA1H,CDC73,CDK2,CIC,COMMD10,CREBZF,CSNK1G3,GATC,GOSR1,MAVS,PAPOLA,PDP2,POLR1B,PPP1R15B,PRR3,RIC3,SLC25A17,SLMO2,STAMBP,VGLL4 miR-92a-3p (and other miRNAs w/seed AUUGCAC) mature microRNA Inhibited -2.464 1.84E-02 ACOX1,ADAM10,ADO,ALPK3,ANKIB1,ANP32E,AP1AR,AZIN1,BMP7,C5orf30,CACNA1H,CASD1,CCNE2,CDCA7L,CEP350,CHGA,CIC,CUL3,DCAF6,DCP1A,DDHD2,DUS2L,ERBB2IP,FAM20C,FAR1,FARP1,FNBP4,GNPDA2,GPRC5A,HERC4,IBTK,ITGA5,ITGA6,JPH2,KIAA1432,KIF3B,LAMP2,LYST,MRPS25,NAA50,NECAP1,NEDD4L,NFIB,OTUD4,PANK3,POLK,RAD21,RGL1,RNF11,RRN3,SEL1L3,SELT,SLC12A2,SLC38A11,SMURF1,SNAPC1,SOBP,SRSF3,STIM2,STX17,TACC2,TGIF1,TPM4,WASL,WDR81,XPR1,ZNF238 miR-921 (miRNAs w/seed UAGUGAG) mature microRNA Inhibited -2.404 1.88E-02 NDFIP2,NIPA2,PGM3,VPS36,ZNF238,ZNF572 miR-204-3p (and other miRNAs w/seed CUGGGAA) mature microRNA Inhibited -2.243 2.01E-02 BAHD1,C7orf57,CNGB1,COQ10A,DDHD2,GALNT12,MCMBP,MTHFD1L,NAP1L5,NR3C1,PRRC1,UNC45B miR-1243 (miRNAs w/seed ACUGGAU) mature microRNA Inhibited -2.214 2.14E-02 CLINT1,FAM210A,GNPDA1,OSBPL11,PRRC1,RAD21,SMAD2,TMEM30A,TSTD2 miR-320b (and other miRNAs w/seed AAAGCUG) mature microRNA Inhibited -2.903 2.55E-02 APBB2,ARHGAP5,BAHD1,BCAP29,C17orf75,CDC73,CHGA,CMPK1,CMTM4,CNBP,CSNK1G3,CTPS1,CYBRD1,CYLD,DCP1A,DHX40,FAM208A,FAR1,GGCX,GMCL1,GPR88,HLTF,IGF2BP3,KIAA1715,MAGI1,MBLAC2,MCTS1,MRPS25,MUT,MZT1,N4BP1,NAP1L5,NEDD4L,NR3C1,OLA1,PFKFB2,PHF1,PPP1CB,PRKAR1A,RAB11A,RAD21,RAD23B,RCN2,RETSAT,SAP30L,SMURF1,SOBP,STIM2,SYNCRIP,TMEM64,TOMM70A,VPS36,VSTM4,WAC,XPO1,YAF2,YIPF5,YWHAG,ZNF281 miR-4660 (miRNAs w/seed GCAGCUC) mature microRNA Inhibited -3.156 2.67E-02 AGAP3,ALG13,CACNB1,ELMOD3,HABP4,MARK4,METTL14,MRPS25,NARFL,NR3C1,PTGS1,RAVER2,RNF40,SLC46A1,STK19,TREML2,TSTD2,WAC miR-486-5p (and other miRNAs w/seed CCUGUAC) mature microRNA Inhibited -2.238 3.04E-02 ARHGAP5,ARMC8,BCORL1,CEP350,CTDSPL,FAM108B1,KCNQ3,MYLK2,NCOA6,NR3C1,NUDT11,PRKD3,SIRT1,SMAD2,SMOC1,SRSF1,SRSF3,TMOD1,UTP15,ZNF37A miR-132-3p (and other miRNAs w/seed AACAGUC) mature microRNA Inhibited -2.047 3.13E-02 ANKRD40,ANP32A,ARHGAP5,BTBD7,CDC40,CLMN,CLYBL,COL5A2,CRTC1,CSDE1,FGFR3,GIGYF1,GRSF1,KDM5C,MAP3K3,NET1,NFIB,NR4A2,PAPOLA,PPP2CB,RB1,SAP30L,SERP1,SIRT1,SLC30A6,SMAD2,SPPL3,SPRYD7,SRSF1,SV2A,TSHZ2,USP38,YIPF5,YWHAG,ZNF238 miR-4643 (miRNAs w/seed ACACAUG) mature microRNA Inhibited -2.157 3.45E-02 ATAD1,CLMN,DRD1,FAM3C,MBIP,RGL1,SERP1,ZNF326 miR-361-5p (miRNAs w/seed UAUCAGA) mature microRNA Inhibited -2.611 3.47E-02 ARMC8,BCORL1,CCNY,DCUN1D5,GGACT,HERC4,HSP90AA1,MAGI1,MFAP3,MYCBP,NFIB,NR4A2,OSBPL11,PGM3,PHAX,RAD23B,RCHY1,RDH11,RRAGB,SYNCRIP,TMEM64,ZNF238 miR-3074-5p (miRNAs w/seed UUCCUGC) mature microRNA Inhibited -2.763 3.71E-02 DSE,FBXO3,KCTD20,MAGI1,MFSD1,MZT1,RAPGEF6,VGLL4,VTA1,WAC,ZNF37A miR-139-5p (miRNAs w/seed CUACAGU) mature microRNA Inhibited -2.167 3.85E-02 ARMC8,ATAD1,AZIN1,CLPX,CUL3,DENR,DNAJC10,FBXL7,FPGT,H2AFV,HDGF,KIAA1033,KLC2,LMO4,MED4,MFSD6,MRPS25,MUT,MYCBP,NFIB,PFDN6,PRKD3,SMARCA4,SRSF1,STAMBP,SV2A,TGIF1,UBE2E3,YAF2,YWHAG miR-199a-5p (and other miRNAs w/seed CCAGUGU) mature microRNA Inhibited -3.055 3.90E-02 ABCA1,ARIH2,B3GNT1,CDC73,CDCA7L,CEP350,CLIP1,CNN1,DDR1,GOSR1,GPRC5A,KIF3B,LAGE3,MAP3K12,MARK4,MFSD6,MRPS25,NAB2,NCOA2,NUPL1,PPM1B,RAD23B,REEP2,RHEB,RNF11,SET,SIRT1,SMARCA4,SMARCAD1,SMC4,SPRYD7,SRSF1,ST6GAL1,TIMM10,TMEM63B,TSPYL1,TXNL1,VPS26A,WDR76,YAF2,ZNF238 miR-129-5p (miRNAs w/seed UUUUUGC) mature microRNA Inhibited -2.643 4.00E-02 ACTN1,ADO,ALG6,CACNA1A,CACNB1,CACNB4,CNBP,CREBZF,DSE,ESR1,GALNT12,GORAB,HDAC2,HDGF,HMGB1,INSIG2,KCTD20,L1CAM,MAN1A1,MATR3,NFIB,NR4A2,NUP50,OLA1,PHAX,PTP4A1,PTPN11,RHOBTB2,RICTOR,SCML4,SSTR2,TOMM40,TSHZ2,UBA6,UBE2O,VPS36,XPR1,YAF2,ZNF238,ZNF281,ZNF608 miR-190a-5p (and other miRNAs w/seed GAUAUGU) mature microRNA Inhibited -2.155 4.43E-02 AZIN1,BLOC1S6,ESR1,KIAA1033,KIAA1432,MED4,MFAP3,MTMR6,NFIB,OTUD4,PLCB4,RGL1,SMAD2,SRSF1,SYNGAP1,TNRC6A,TOMM5,XPO1 miR-224-3p (and other miRNAs w/seed AAAUGGU) mature microRNA Inhibited -2.186 4.53E-02 MZT1,PTPN11,RAPGEF6,RSL24D1,SDE2 let-7a-5p (and other miRNAs w/seed GAGGUAG) mature microRNA Inhibited -2.613 4.57E-02 ADAMTS8,ADRB3,AKAP5,ALPK3,ARG2,ARMC8,B3GNT1,BAHD1,BCAP29,BLOC1S6,BTF3L4,CACFD1,CCNY,CEP120,CHUK,CLDN12,COL11A1,COL14A1,COL3A1,COL4A2,COL5A2,CSDE1,CTPS1,DCUN1D2,EIF2S2,EIF3J,FAM208A,FAM96A,FARP1,GDF6,GRPEL2,H2AFV,HABP4,HTR4,ICOS,IFRD1,IGF2BP3,LAMP2,LOXL4,MAP3K3,MAPK6,MARCH9,MEIS3,MRPS24,MYCBP,NAA30,NEDD4L,NEK3,OSMR,PDP2,PLD3,POLR2D,PPARA,PPP1R15B,PRDM1,RB1,RCN1,RICTOR,RNF20,RNF7,SAP30L,SLC30A6,SMAD2,SMARCAD1,SNAP23,SPRYD7,STAB2,STARD3NL,STX17,SUCLG2,SYNCRIP,TBKBP1,TRABD,USP38,UTP15,WASL,YAF2,YIPF1,ZCCHC3,ZCCHC9,ZNF200 miR-96-5p (and other miRNAs w/seed UUGGCAC) mature microRNA Inhibited -3.745 4.59E-02 ABAT,ABCA1,ALG2,ANKIB1,ARHGDIA,C5orf30,C7orf41,CACNB1,CACNB4,CAPNS1,CCNG2,CCNY,CPNE3,CROT,CRYGS,CTDSPL,CUL5,CYLD,DDHD1,DENR,DLAT,EIF3J,FARP1,GCNT1,HSP90AA1,IMPAD1,INSIG2,KPNA3,L1CAM,LOXL4,MAGI1,MAP3K3,MBLAC2,MCMBP,MCTS1,MFAP3,N4BP1,NAA50,NUP50,PDGFRA,PGGT1B,PLCB4,PRC1,PRKAR1A,PRR3,PTP4A1,RAB11FIP5,RAB2A,RAD23B,RAVER2,RDH11,RICTOR,RWDD4,S1PR2,SAP30L,SBDS,SCML4,SLC12A2,SLC33A1,SLC46A1,SNAP23,ST6GAL1,STAM2,STK19,TBC1D22A,TMX1,TNRC6A,TOPORS,TRIM56,TSHZ2,USP5,YWHAG,ZCCHC3,ZER1,ZNF175 miR-1953 (and other miRNAs w/seed GGGAAAG) mature microRNA Inhibited -2.153 4.64E-02 ATXN2L,CNP,PANK3,PPIP5K2,RAVER2,STRADA,TERF1,TRIM68 miR-7a-5p (and other miRNAs w/seed GGAAGAC) mature microRNA Inhibited -2.271 4.82E-02 BCAP29,BLOC1S4,CACNB4,CADM3,CNOT8,CNP,COL2A1,CTDSPL,CUL5,FBXL7,FPGT,GATA5,GIGYF1,GOSR1,H2AFV,NDFIP2,NFIB,OSBPL11,PATL1,RAB11FIP5,RB1,RNF20,SEC23IP,SERP1,SLC12A2,SLC25A15,SMARCA4,SMG6,SPAG9,SRSF1,STAMBP,TBKBP1,TNRC6A,VMA21,VPS26A,WIPF2,ZSCAN29 AKT1 kinase Inhibited -2.411 1.09E-01 BIRC3,CDK2,CFLAR,CSN2,ESR1,GCLC,HMGCS1,MATR3,MUT,NPPA,PDGFRA,PPARA,PRKAR1A,RAB11A,TIMP1,ZWINT caffeic acid phenethyl ester chemical toxicant Inhibited -2.178 1.36E-01 ABL1,BIRC3,CDK2,ERCC1,ESR1,GSR,RB1,ST13 RHOA enzyme Inhibited -2.207 2.03E-01 COL10A1,COL3A1,ESR1,NOS3,NPPA,PPARA SRF transcription regulator Inhibited -2.179 2.44E-01 Cald1,CAMP,CNN1,CNN2,CSRP2,CYLD,FGF1,FILIP1L,GLRX3,ITGA6,MPL,MTMR6,NPPA,NR4A2,RAB27B,SCAP,SERPIND1,SLC8A1,TMBIM4,ZYX ADIPOQ other Inhibited -2.183 2.67E-01 ACOX1,COL3A1,CSF3,IL17A,IL4R,PPARA,PPARD,PRDX3,TIMP1 ERK group Inhibited -2.170 3.35E-01 ACTN1,ADAM10,ARG2,CLDN4,CLU,CYP1A1,GCLC,IFNAR1,IL17A,PPARD,PRDM1,TGM2,TIMP1 FIGLA other Inhibited -2.000 4.04E-01 HDAC2,IVNS1ABP,NLRP5,PDZK1 Mek group Inhibited -2.580 4.37E-01 CLU,DDR1,DDX21,ESR1,ITGA6,PDGFRA,RETSAT,ST6GAL1 zinc chemical drug Inhibited -2.216 4.86E-01 CNN1,IL17A,IREB2,RB1,TGM2 CD28 transmembrane receptor Inhibited -2.052 1.00E00 CDK2,CFLAR,CLIP1,COX6C,CTLA4,GTF2IRD1,GTPBP4,HDAC2,ICOS,IL17A,IL7,LTA,NDFIP2,NOS3,PPA1,RAB2A,RAD23B,RPS14 kainic acid chemical toxicant Inhibited -2.162 1.00E00 HDC,NR3C1,NR4A2,RELN,TIMP1 hydrogen peroxide chemical - endogenous mammalian Inhibited -2.518 1.00E00 CCNH,CLU,COX6C,CYP1A1,DPAGT1,EID1,FXYD2,HDAC2,HDC,HMGB1,ITGA6,MAPK14,NAT10,NOS3,PDGFRA,RCN1,RPL21,SIRT1,SQLE,TGM2 HNF4A transcription regulator 0.786 8.82E-09 ABCB8,ACOT13,ACOX1,ACTN1,ADSS,AGTPBP1,ARG2,ARMC8,ASUN,ATG4C,AXIN2,BCLAF1,BLOC1S6,BMP7,BNIP1,BRD8,C11orf58,C12orf49,CAPZA2,CBR3,CBS,CCDC115,CCNE2,CCNG2,CCNH,CCT8,CD46,CDCA7L,CDK2,CDK5,CDK8,CEP19,CES2,CLDN12,CLPX,CLYBL,CNBP,CNOT3,COPB1,COPS8,CROT,CRY1,CUL5,CYB561D2,CYLD,CYP1A1,DDOST,DDX10,DPAGT1,EID1,ELMOD3,ELP2,FASTKD2,FBP1,FBXL7,FDX1,FH,GGCX,GSTM4,HMGB1,HSD17B4,IFNAR1,ITGA6,IVNS1ABP,KDM5C,KHDRBS1,KIF20A,KIF3B,KLC4,KRT8,LATS1,LDB1,MADCAM1,MAP3K3,MFSD1,MICU1,MRPL43,MRPL44,MRPL46,MRPL53,MUT,NAA50,NARS2,NAT10,NCK1,NECAP1,NOC3L,NOL7,NSL1,NUDT11,NUP54,OSBPL11,OSMR,P2RY14,PAAF1,PALMD,PAPOLA,PARP4,PDZK1,PFDN6,PGGT1B,PGM3,PLAA,POLR1B,PPARA,PPARD,PPIP5K2,PPP1R15B,PRMT7,PRR3,PTGES3,PTPN11,RAB11A,RAB18,RAB2A,RABAC1,RASL12,RBM18,RDH11,RFC5,RNF40,RPL18A,RSL24D1,SAP30L,SEC11C,SEC23IP,SERPINA3,SF3B1,SGCE,SLC33A1,SLC35A3,SLMO2,SNAP23,SNAPC1,SNX5,SPATA5L1,SRSF1,SRSF11,SRSF2,ST13,STAM,STAM2,STAMBP,STK19,STRAP,STX17,TAF6,TBC1D10A,TDRKH,TERF2IP,THOC3,TMEM101,TMEM208,TMEM30A,TSN,TXNL1,UBE2M,USP5,UTP18,WASL,WBP4,WNT11,XPO1,XPR1,ZCCHC9,ZNF146,ZNF175,ZNF189,ZNF281 pitavastatin chemical drug -0.633 1.45E-04 ABCA1,ACADM,ACOX1,HMGCS1,NOS3,SIRT1,SQLE miR-450b-3p (and other miRNAs w/seed UGGGAUC) mature microRNA -0.211 2.75E-04 ABAT,BAHD1,C12orf49,C5orf15,CDK2,CFLAR,H2AFV,PPIE,RCN1,SCML4,SELT,SYNCRIP,TGM2,TSTD2 miR-365-3p (and other miRNAs w/seed AAUGCCC) mature microRNA -1.968 2.78E-04 DCUN1D5,DLAT,FAM3C,FGF1,FLI1,GRPEL2,HMGCS1,IMPAD1,KIAA2026,KIRREL,LAMP2,LDB1,MARK2,MLL5,MYCBP,NAA50,NFIB,NR3C1,NSL1,PANK3,PCMTD2,PHF12,PLCB4,PRDM1,RHEB,RICTOR,SET,SMAD2,SRSF1,SSTR2,TMEM106C,TRAM1,USP33,VGLL4,VPS36 miR-644a (miRNAs w/seed GUGUGGC) mature microRNA -1.356 3.65E-04 ANKRD22,BNIP1,CLUAP1,DAK,DRD1,FBXO2,GALNTL1,GPR88,HABP4,IMPAD1,KIRREL,KRT25,MXRA7,MYLK2,PDP1,PPARA,RAB11FIP5,RNF130,SAMD11,TBC1D20,TSPAN7,ZNF37A XBP1 transcription regulator 1.969 5.84E-04 ALG2,APBB2,COG6,COL10A1,COL2A1,COPB1,DDOST,DNAJC10,ESR1,FKBP7,GGCX,PRDM1,RAB3A,RABAC1,Rrbp1,SEC11C,SEC22B,SERP1,SSR1,SSR4,TRAM1,VAMP4,YIPF5 sirolimus chemical drug -1.136 9.60E-04 ACADM,ADSS,ATP1A1,BCORL1,CFLAR,COX6C,CSF3,CSN2,ERCC1,GCLC,HMGB1,HSP90AA1,HSPD1,IL4R,NOS3,PDGFRA,PPARD,PRKAR1A,PTP4A1,RPL18A,RPL19,RPL21,RPL29,RPL35,RPLP0,RPS10,RPS12,RPS14,RPS15,RPS19,RPS2,RPS3,RPSA,SIRT1,SLC38A3,SQLE,SRSF3 miR-297a-5p (and other miRNAs w/seed UGUAUGU) mature microRNA -1.294 1.09E-03 ABO,C8orf37,FAM108B1,FKBP7,PNRC1,PRDX3,RNF11,TOMM20 miR-494-3p (and other miRNAs w/seed GAAACAU) mature microRNA -1.707 1.22E-03 ADAM10,ANKRD40,ARHGAP5,ATP5G2,BCAP29,C12orf23,CBS,CCNY,CNBP,CREBZF,CUL3,DCP1B,DLD,ELF1,FGFR2,GATC,GOSR1,HDGF,HMGCS1,KDM5C,LAMP2,LGALSL,LMO4,NEDD4L,NFIB,PARP16,PDGFRA,PPM1B,PTPN11,PUS7L,RAD23B,RWDD4,SERP1,SIRT1,SLC12A2,SLC35F5,SLC6A2,SOBP,SPATA5,SPPL3,STAM,SYNCRIP,TACC2,TMOD1,TSHZ2,UFL1,UNC45B,YAF2,ZNF281,ZRANB3,ZZZ3 miR-4421 (and other miRNAs w/seed CCUGUCU) mature microRNA -1.136 1.32E-03 C12orf49,C3orf45,CHUK,CLMN,CSF3,EGLN3,EMX2,H1F0,PRR3,SEC23IP,SRSF1,TDRKH,UBE3B,VPS36,ZSCAN29 miR-95 (miRNAs w/seed UCAACGG) mature microRNA -1.248 1.43E-03 DUS2L,EID1,FKBP7,HDGF,LAMC3,MATR3,SMAD2 ESRRA ligand-dependent nuclear receptor 1.836 1.50E-03 ACADM,ACOX1,CSRP2,DLAT,FAM100A,FBP1,HMGCS1,HSD17B4,HSD3B2,IDH3A,LIPE,PDP1,PPA1,PPARA,PPM1B,SIRT1,SMARCA4,WNT11 darusentan chemical drug 1.65E-03 COL3A1,NOS3,NPPA methylnitrosourea chemical toxicant 1.75E-03 ATP1A1,CDK2,CLU,MNAT1,PSME1,RPS11,RPS12 beta-estradiol chemical - endogenous mammalian -0.560 1.86E-03 ABCA1,ACADM,ACOX1,ALDH7A1,ART3,BCL10,BLOC1S6,CACNB1,CCNE2,CCNG2,CDK2,CDK5,CHGA,CLDN4,CLU,CLYBL,CNBP,CNN1,CNN2,CNP,COL3A1,CRHR2,CRNKL1,CSN2,CTLA4,CTPS1,CYP1A1,DDOST,DDR1,DRD1,DRD5,EIF3J,ELF1,ESR1,FGFR2,FGFR3,FMO5,GCLC,GPR88,GPRC5A,GSR,GTF2IRD1,HCRT,HDAC11,HDGF,HMGCS1,HSD11B2,HSD17B4,HSPD1,HTR4,IFNGR2,IFRD1,IGF2R,IL17A,IL4R,IL7,INPP4B,INSIG2,KLK1,KRT8,L1CAM,LAGE3,LAMB2,MAPK14,MCM5,NCOA2,NEDD4L,NOS3,NPPA,NR3C1,PDGFRA,PDZK1,PLAA,PLAT,PNRC2,PPARA,PPP2CB,PRC1,PTGS1,PTP4A1,PTPN1,PTPN11,PTPN5,RAB2A,RALA,RB1,RCN2,RPL21,RPS11,Rrbp1,RYBP,S100A2,SERPINA3,SET,SIRT1,SLC12A2,SLC25A15,SLC8A1,SPAG9,SQLE,SRD5A1,SRSF1,SRSF2,SSR1,SSTR2,STK3,TANK,TREML2,TXNL4A,WNT11,XPO1,ZNF238,ZYX miR-4323 (miRNAs w/seed AGCCCCA) mature microRNA -1.138 1.92E-03 AMIGO2,BAHD1,CAMKK1,CIAPIN1,CMTM4,CNN2,CNP,EXOC6,FGF1,GPRC5A,GRSF1,HDGF,KIF3B,MARK4,MCTS1,ME3,NASP,PFKFB2,RANBP6,RCN2,RELN,RGL1,RPL13,S1PR2,TNRC6A,ZBTB7C miR-764 (miRNAs w/seed CAGGUGC) mature microRNA -1.499 1.98E-03 ADO,ALG1,ALG6,ANKRD40,BOK,C1orf43,CLIP1,GPN3,MAPRE2,PDCD1,PDP2,PTGS1,RCN2,SLC33A1,UBE2E3,ZNF572 gentamicin chemical drug 0.200 2.14E-03 ABAT,ACADM,ACSL3,AZIN1,CAND1,CBS,CLU,CSRP2,CYP1A1,DDX50,HSD11B2,HSD17B4,HSP90AA1,IFRD1,KLK1,LIG4,MAPK6,MYBBP1A,MYO1G,NUPL1,PHAX,PNN,PTP4A1,PTPN1,TIMP1 TP73 transcription regulator 0.224 2.46E-03 BMP7,CAMLG,CCNG2,CLMN,COL5A2,IL4R,IL7,MFAP3,PNRC1,PPP4R2,PROCR,PTP4A3,RB1,RB1CC1,RELN,S100A2,TP53I3,TSPYL1,XRCC1,ZNF175 miR-382-5p (miRNAs w/seed AAGUUGU) mature microRNA -1.136 2.82E-03 ARIH2,BCORL1,BTBD7,CNBP,FAM45A,FLI1,GATC,GGACT,KCNQ3,MATR3,NCOA2,NDFIP2,NFIB,OLA1,PLEKHF2,PTP4A1,RNF19A,SMARCAD1,SMOC1,SRSF1,SSR1,SYNCRIP,USP8,XPR1 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine chemical drug 0.478 2.91E-03 CCT8,CSN2,HSP90AA1,HSPD1,PSME1,RAB11A,RAB2A,RB1 miR-374b-5p (and other miRNAs w/seed UAUAAUA) mature microRNA -0.820 3.04E-03 ABAT,ACTN1,ADAM10,ARHGAP5,ATP1A1,AXIN2,BCAP29,BMPER,BTBD7,C11orf58,CAPZA2,CEP350,CNOT8,CNST,CYBRD1,DGAT2,EIF2S2,FECH,FGFR2,G2E3,HERC4,KIAA1143,KIAA1432,KIAA1468,KIF20A,L1CAM,LMO4,LYST,MAPK6,MBLAC2,MZT1,NCK1,NCOA6,NEDD4L,NFIB,NR3C1,NR4A2,PCF11,PDP2,PHRF1,PNRC1,PRDX3,PTPN11,RGS14,RYBP,SEC23IP,SLIT3,SMARCAD1,SPPL3,SPTLC1,STX17,TNRC6A,UBE2E3,WASL,WRN,ZER1 miR-433-3p (and other miRNAs w/seed UCAUGAU) mature microRNA -1.671 3.04E-03 AGPAT5,ATAD1,AZIN1,C7orf41,CLINT1,CLIP1,CLYBL,CMTM4,CRLF3,CUL5,FAM208A,FTSJD1,GCLC,IMPAD1,KIAA1432,NAA30,NR3C1,NSL1,PDP2,RAD21,RWDD4,SCN1B,SLC25A46,SLC30A6,SMAD2,SRSF3,STK38,SYNCRIP,UBE2D2,UXS1,YWHAG,ZNF567 AGXT enzyme 3.19E-03 COL3A1,NPPA dexrazoxane chemical drug 3.19E-03 DPAGT1,NPPA TP53 transcription regulator -0.888 3.24E-03 ABAT,ACSL3,ACTN1,ARHGAP5,ATP1A1,BIRC3,BMP1,BNIP3,BOK,Cald1,CAMLG,CAND1,CAPNS1,CCNE2,CCNG2,CDK2,CES2,CFLAR,CHUK,CLU,CNN1,CNN2,COL14A1,COL2A1,COL3A1,COL5A2,COPB1,CYP1A1,DDR1,DLD,ERCC1,ESR1,ETFA,FAM3C,GSR,HDAC2,HDC,HMGB1,HMGCS1,HSP90AA1,HSPD1,IL7,KNTC1,KRT8,LAMB2,MAD2L1,MCM5,MRPL46,NOS3,PDGFRA,PDP1,PEX2,PGM3,PIAS2,PIK3R4,PLXNB2,PPARD,PPM1B,PPP4R2,PRC1,PRDM1,PRDX3,PTGS1,PTP4A1,PTP4A3,PTPN1,PTPN11,RACGAP1,RB1,RB1CC1,RECQL4,RPSA,S100A2,SIRT1,SMC4,SMURF1,SNX5,SQLE,SRSF3,STAMBP,TANK,TDG,TGM2,TMED7,TP53I3,TRAP1,UGDH,XPO1,ZNF175,ZYX SMURF2 enzyme 3.48E-03 AXIN1,SKIL,SMAD2,TGIF1 TGFB1 growth factor -0.245 3.62E-03 ABCA1,ABL1,ACSL3,ACSS1,ACTN1,ADAM10,ADI1,ALDH3A2,ANKLE2,ASUN,B3GNT1,BMP1,BMP7,CAMP,CAPNS1,CBR3,CCDC28A,CCNE2,CCNG2,CD46,CDK2,CENPE,CHMP3,CLDN4,CLU,CNN1,CNN2,COL11A1,COL2A1,COL3A1,COL4A2,CRHR2,CRYGS,CSRP2,CTLA4,CTPS1,CUL5,DDX21,DDX5,DNAJB6,EPB49,FGFR2,FILIP1L,FLI1,GCLC,GCNT1,GDF6,GNAO1,GPRC5A,HDAC2,HDGF,HLTF,HNRPDL,HSP90AA1,IFRD1,IL17A,IL17RB,IL4R,ITGA5,ITGA6,ITGA7,KCNQ3,KPNA3,KRT8,L1CAM,LDB1,MAPK14,MAPK6,MAPKAPK2,NAB2,NET1,NFIB,NIPA2,NOC3L,NOS3,NPPA,NR4A2,P2RY14,PAX8,PDXK,PPARD,PRC1,PTGS1,RAB18,RACGAP1,RAD21,RB1,RDH11,RFC5,RYBP,SAE1,SERP1,SERPINA3,SKIL,SLIT3,SMAD2,SMC4,SMURF1,SOD3,SRSF2,SRSF3,SSTR2,STRAP,TACC2,TBC1D1,TGIF1,TGM2,TIMP1,TSPAN7,TTLL3,ZWINT,ZYX miR-582-5p (miRNAs w/seed UACAGUU) mature microRNA -1.400 3.88E-03 AZIN1,CDC40,FAM108B1,FPGT,GCLC,INSIG2,MLL5,PGGT1B methylselenic acid chemical reagent 0.762 3.90E-03 ACSL3,ALDH3A2,BIRC3,CDK2,CDK5,CFLAR,CLU,ERCC1,ESR1,H1F0,INPP4B,MAPK14,MCM5,NEDD4L,PLCB4,PPM1B,RABAC1,RB1,RDH11,RFC5,STX7,TAF6,TNFRSF25,UGDH,UXS1 miR-4512 (miRNAs w/seed AGGGCCU) mature microRNA -1.978 4.22E-03 ABL1,BAHD1,C11orf58,C5orf30,CDC40,CNBP,CRYL1,DARS,DDHD2,GSTM4,MRPL45,RNF123,SLC38A3,SYNGAP1,TMED7,TMEM242,TSTD2 miR-28-3p (and other miRNAs w/seed ACUAGAU) mature microRNA -1.387 4.34E-03 CMPK1,CNGB1,GNPDA1,SRXN1,WASL miR-4742-5p (miRNAs w/seed CAGGCAA) mature microRNA -0.499 4.64E-03 C2CD5,CFLAR,CHMP3,CSDE1,CSNK1G3,FAM35A,LAMP2,OIP5,PLEKHF2,PPM1B,SPATA5L1,VGLL4 miR-4301 (miRNAs w/seed CCCACUA) mature microRNA 0.025 4.67E-03 CACFD1,CDC73,CREBZF,GCNT1,RNF11,SEC23IP,SRXN1,TSEN15,VAMP4,ZNF146 FSH complex 0.966 5.14E-03 ACTN1,ALDH3A2,CARD10,CENPI,CFLAR,CHUK,CLIP1,CREBZF,ESR1,FDX1,FILIP1L,GCLC,GPRC5A,HSD3B2,HSF2,ITGA5,MAPK14,MAPK6,MAPRE2,NPPC,PDXK,PLAT,PPARA,PPP1CB,PRKAR1A,PTGS1,PTP4A1,PTPN1,RAB2A,SMAD2,SMARCA4,SNAP23,SRD5A1,TIMP1 abatacept biologic drug 5.30E-03 ICOS,IL17A,PDCD1 RLN1 other 5.30E-03 ESR1,NPPA,PRKAR1A miR-4668-3p (miRNAs w/seed AAAAUCC) mature microRNA 5.30E-03 BCL10,CUL5,EXOC6 miR-4284 (miRNAs w/seed GGCUCAC) mature microRNA -1.560 5.55E-03 ACOT13,ADO,ALG2,ALKBH4,APBB2,C17orf75,CDK20,CNN2,COMMD10,CUL3,GATA5,GCLC,GSTM4,METTL2A,NAP1L5,OSMR,PDP2,PPARD,PRR3,RBM43,S1PR2,SGOL1,STAT2,TMEM180,TRIM13,TSPYL1,UGDH miR-4662a-5p (miRNAs w/seed UAGCCAA) mature microRNA -1.539 5.57E-03 C7orf57,CEP120,DFFA,FECH,GMCL1,HDAC2,IRX3,PTP4A1,SOBP miR-4280 (miRNAs w/seed AGUGUAG) mature microRNA -0.059 5.92E-03 BCLAF1,C3orf45,CEP192,RAB12,SLC38A11,TOMM20 miR-4671-3p (miRNAs w/seed UAGUGCA) mature microRNA -1.688 6.22E-03 ALDH3A2,CCNY,CLIP1,FAM13B,FNBP4,LGALSL,LIG4,MAPK6,NIPA2,PTPN1,STIM2,TMOD1,ZNF800 miR-196a-5p (and other miRNAs w/seed AGGUAGU) mature microRNA -1.642 6.57E-03 ABL1,BLOC1S6,CDC73,CEP350,COL14A1,COL3A1,CTPS1,DDHD1,EIF2S2,GRPEL2,HABP4,ICOS,IGF2BP3,IMPAD1,NEDD4L,OSMR,PDGFRA,PPP1R15B,RAD23B,RAVER2,RBM12B,RICTOR,SAP30L,SERP1,SLC30A6,SMURF1,SSR1,SYNCRIP,TMX1,ZCCHC3,ZNF200 miR-499b-5p (miRNAs w/seed CAGACUU) mature microRNA -1.495 7.39E-03 AGPAT5,C17orf75,CNOT8,GORAB,NIPA2,RWDD4,SRXN1,TDG miR-3675-5p (miRNAs w/seed AUGGGGC) mature microRNA 0.135 7.42E-03 ALG13,ALKBH4,AMFR,C17orf75,CDK2,CHMP3,DFFA,DLD,ELMOD3,FGFR2,HTR4,KNTC1,LGALSL,PATL1,SYNGAP1,TBC1D20 miR-1179 (miRNAs w/seed AGCAUUC) mature microRNA -1.977 7.50E-03 ANKIB1,FANCL,GDF6,PTGR2,SNAPC1,TUBD1,UBA6 MGEA5 enzyme -0.426 7.54E-03 CCNG2,CDCA7L,CDK2,CDK5,CIAPIN1,CLDN12,CNOT3,ELF1,FBP1,FGFR1OP,FGFR4,GTF2IRD1,HMGCS1,HSF2,IFNGR2,IGF2BP3,LPXN,MAP3K3,RB1,S100A2,TIMP1,WNT11 MYC transcription regulator 1.440 7.57E-03 ACTN1,AIMP2,C12orf49,C1QBP,Cald1,CAPNS1,CCNE2,CCNG2,CDK2,CFLAR,CLEC3B,CLU,CNBP,CNP,COL14A1,COL2A1,COL3A1,COL4A2,COL5A2,CSDE1,CSRP2,DDX21,DDX5,EIF2S2,FECH,GCLC,Gm10052/Gm5803,GSR,HDAC2,HSP90AA1,HSPD1,IREB2,ITGA6,KLK1,LAMB2,LAMP2,MAD2L1,MAPKAPK5,MCM5,MYBBP1A,NPPA,POLR1B,PPARD,PRDX3,RB1,RPL13,RPL19,RPL21,RPL35,RPS12,RPS19,SARDH,SMS,SRSF2,TDG,TIMP1,TP53I3,TRAP1,TSPAN7,VARS,WRN,XPO1 miR-4645-3p (miRNAs w/seed GACAGUA) mature microRNA -1.177 7.75E-03 ATF1,CCT8,MANEA,MLL5,NAA50,NAP1L5,REEP5,SIKE1,TOMM70A,WRN GnRH analog biologic drug 0.000 8.05E-03 ABO,ACTN1,AKAP10,ANKLE2,CACNB1,CAPNS1,CDK5,CUL5,DDOST,HNRPDL,MED24,MICU1,MRPS31,MXRA7,N4BP1,NCOA6,NPPA,NR4A2,PLD3,PPP2CB,RALA,RELN,SEC22B,SLC35A3,SMAD2,SRSF3,SSR1,TERF1,UBE2M,ZBTB1 SOX5 transcription regulator 8.13E-03 COL2A1,FGFR3,LIPE miR-4662a-3p (miRNAs w/seed AAGAUAG) mature microRNA 8.13E-03 LAMP2,PRDM1,USP38 BCAR1 enzyme 8.13E-03 ESR1,NAB2,RALA PBX2 transcription regulator 8.13E-03 COL5A2,HOXB2,PDGFRA selenomethylselenocysteine chemical - endogenous mammalian -0.447 8.18E-03 ATP1A1,CLU,PSME1,RPS11,RPS12 SPRY2 other -1.387 8.18E-03 AXIN2,FGFR3,LMO4,PTPN1,SFTPA1 miR-374c-5p (and other miRNAs w/seed UAAUACA) mature microRNA -1.452 8.18E-03 C11orf58,C8orf37,CASC4,FNBP4,IL7 TFAP2A transcription regulator 0.478 8.22E-03 ABCA1,BIRC3,BLOC1S6,BOK,DRD1,FGFR4,MCM5,PPARD,RAB27B,RPLP0,STX7 miR-3118 (and other miRNAs w/seed GUGACUG) mature microRNA -1.217 8.36E-03 APBB2,CRY1,GATC,GGCX,GNAO1,GRPEL2,HABP4,HSP90AA1,IDH3A,KPNA3,MAGIX,N4BP1,NDFIP2,OSMR,PAX8,PCMTD2,PISD,PPP1R8,RBM22,RNF185,SEC22B,SRSF2,TMOD1,WWOX miR-4291 (and other miRNAs w/seed UCAGCAG) mature microRNA -1.423 8.38E-03 ARPC5L,COG6,FGF1,KIAA1432,LGALSL,NAA30,OTUD4,PGGT1B,PNRC2,SDAD1,SLC35A3,TMEM30A,VSTM4,ZBTB1 LTA cytokine -0.640 8.58E-03 CCL19,COL2A1,CSN2,HDC,IL17A,ITGA5,MADCAM1 HGF growth factor -1.068 8.61E-03 AIMP2,ANP32A,BIRC3,CCNE2,CCNG2,CD46,CDK2,CFLAR,CNBP,COL2A1,COL3A1,COPB1,CRY1,CUL3,DDX21,FAM3C,HDGF,ITGA6,L1CAM,LATS1,LTA,MAD2L1,MAPK14,MAPKAPK2,MCM5,MELK,NAB2,NCOA2,NEK3,NOS3,NR4A2,OSMR,PLK4,PNRC1,PPARD,PRC1,RARRES2,RNF103,SKIL,TIMP1 EMP2 other 9.21E-03 ITGA5,ITGA6 miR-369-3p (miRNAs w/seed AUAAUAC) mature microRNA 9.21E-03 C8orf37,SLC35F5 S100A1 other 9.21E-03 NPPA,SLC8A1 5R,11R-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol chemical reagent 9.21E-03 CRHR2,ESR1 miR-515-5p (and other miRNAs w/seed UCUCCAA) mature microRNA -1.289 9.74E-03 COPS8,FGFR2,MATR3,NDFIP2,PDGFRA,POLR2D,RBM43,RWDD4,SLC35A3,TMEM242,ZWINT miR-3589 (and other miRNAs w/seed AGGAAAC) mature microRNA -1.023 9.87E-03 CCNG2,CLMN,PLCB4,SGOL1,WAC COL4A3 other 9.87E-03 COL3A1,COL4A2,DDR1,MAPK14,TIMP1 miR-562 (miRNAs w/seed AAGUAGC) mature microRNA -0.059 1.11E-02 CRNKL1,DLAT,DLD,GPN3,NOC3L,PTGR1 n-nitrosomethylbenzylamine chemical toxicant 1.13E-02 ALDH3A2,BLOC1S4,CCDC115,DDX5,FTSJ3,HSP90AA1,LAMP2,MAPK6,PIAS2,PRKAR1A,PTGS1,RAD23B,RB1,RRAGB,TXNL1 miR-143-3p (and other miRNAs w/seed GAGAUGA) mature microRNA -0.614 1.15E-02 BCORL1,CACNA1A,CCDC149,CNNM1,COL5A2,CREBZF,CRLF3,CSNK1G3,FAM108B1,FAR1,FGF1,GCNT1,GSR,IGF2R,ITGA6,KIF3B,KLC2,LMO4,LOXL4,MARK2,MFAP3,MFSD6,NECAP1,OTUD4,PDGFRA,PRC1,PTPN11,RAB2A,RICTOR,SLC25A15,SMNDC1,SOBP,SRSF11,TPM4,UBE2E3,VPS37A,ZNF182 ALDH1A1 enzyme 1.17E-02 ACADM,PPARA,PPARD HGS other 1.17E-02 ESR1,STAM,STAM2 HSPG2 enzyme 1.17E-02 COL10A1,COL2A1,FGFR3 poloxamer chemical reagent 1.17E-02 ACADM,ACOX1,PPARA miR-1253 (miRNAs w/seed GAGAAGA) mature microRNA -0.391 1.18E-02 C17orf75,FBXL7,KIAA1432,SOBP,UNC45B ramipril chemical drug -0.447 1.18E-02 COL3A1,COL4A2,DDR1,MAPK14,TIMP1 S-nitroso-N-acetyl-DL-penicillamine chemical reagent -1.109 1.18E-02 BNIP3,NOS3,PPARD,PRDM1,TIMP1 miR-2861 (and other miRNAs w/seed GGGCCUG) mature microRNA -0.840 1.18E-02 ABL1,ARHGDIA,BMP1,C1orf43,CACNA1H,CAPNS1,CCDC149,CLU,CMTM4,COQ10A,EMID1,FBXL7,GLIS2,GNAO1,GSTM4,H2AFV,L1CAM,LAMC3,LTA,MAP3K12,MARCH2,MARK2,MRPL28,MYLK2,NOC3L,PDCD1,PEX2,POLR2D,PPARA,REEP2,RPL28,SEC22B,SERPIND1,SLC46A1,SNRNP40,SOBP,TBC1D20,TBKBP1,TCOF1,TMEM101,UBE2O,UBE3B,ZBTB7C,ZNFX1 miR-4436b-5p (miRNAs w/seed UCCACUU) mature microRNA -1.881 1.22E-02 ALG13,BCAP29,CDK20,NCK1,PHF10,PTP4A1,RBM26,SLC12A2,TM9SF1,ZNF37A miR-879-5p (and other miRNAs w/seed GAGGCUU) mature microRNA -0.948 1.24E-02 COQ10A,CROT,CSF3,ERBB2IP,GORAB,GSTM4,MNAT1,PRSS12,RICTOR,SENP7,TDRKH,TTC5 miR-488-3p (miRNAs w/seed UGAAAGG) mature microRNA -0.904 1.30E-02 ACOX1,AKAP5,AP1AR,APBB2,ARIH2,BTBD7,C11orf58,C7orf41,CEP70,CLINT1,CREBZF,CTDSPL,CYBRD1,DLD,EIF2S2,FGD1,FGFR3,GORAB,GRPEL2,KCNQ3,KCTD20,MAVS,NFIB,OTUD4,RYBP,SMAD2,SOBP,SPAG9,SRSF1,STAM,STX7,UTP15,VAMP4,ZNF281 miR-216a-5p (miRNAs w/seed AAUCUCA) mature microRNA -0.914 1.31E-02 ACOX1,BAHD1,CIC,CLDN12,CLMN,CLYBL,CMPK1,FAM210A,FAM45A,FGF1,FTSJD1,HNRPDL,IMPAD1,MAPRE2,MATR3,NAA50,NR3C1,PDP2,PHAX,PLAA,PNRC1,PTP4A1,RAB11A,RNASEH1,SEC22B,SIKE1,YLPM1 miR-616-3p (miRNAs w/seed GUCAUUG) mature microRNA 0.000 1.34E-02 COL5A2,MZT1,RAB27B,RDH11 glutamyl-Se-methylselenocysteine chemical - endogenous mammalian 0.000 1.34E-02 ATP1A1,CLU,PSME1,RPS11 ENG transmembrane receptor 1.34E-02 ITGA5,ITGA6,NOS3,SMAD2 App other -1.912 1.43E-02 CSNK2A2,CUL3,ELMOD3,L1CAM,MAGI1,NARS2,PRPF40B,RELN miR-4717-5p (miRNAs w/seed AGGCCAC) mature microRNA -0.735 1.45E-02 BCLAF1,CEP350,FBXO3,FLI1,GGCX,LOXL4,MYLK2,NOC3L,NUP50,OSMR,PARP16,PGGT1B,RBM22,RNASEH1,TSTD2 mono-(2-ethylhexyl)phthalate chemical toxicant 1.463 1.53E-02 ACADM,ACOX1,CYP1A1,DGAT2,EIF3J,FH,IDH3A,LIPE,MUT,N4BP1,NFIB,PPA1,PPARA,PPARD,SUCLG2,WDR43 S1PR2 G- coupled receptor 1.60E-02 NOS3,S1PR2,TIMP1 abscisic acid chemical - endogenous non-mammalian 1.60E-02 NCOA6,NOS3,PIAS2 levamisole chemical drug 1.60E-02 CLU,DRD1,NOS3 isoproterenol chemical drug 0.909 1.70E-02 ABL1,ACSL3,ADRB3,ALDH3B1,ATP1A1,CDK5,NPPA,PLAT,PRKD3,RAB18,TBC1D10A,TIMP1,XRCC1 miR-1273e (miRNAs w/seed UGCUUGA) mature microRNA -0.368 1.74E-02 DDHD1,DR1,NEDD4L,POC1B,POLR3B,RRN3,SOBP,TPM4 FEZF1 other 1.77E-02 CDK2,TIMP1 nebivolol chemical drug 1.77E-02 NOS3,PTGS1 KLF16 transcription regulator 1.77E-02 CYP1A1,DRD1 LRP8 transmembrane receptor 1.77E-02 ABCA1,CLU RGL2 other 1.77E-02 NPPA,RALA GAL3ST1 enzyme 1.77E-02 ITGA5,ITGA6 PDCD6IP other 1.77E-02 DRD1,ESR1 DBI other 1.77E-02 PPARA,PPARD HESX1 transcription regulator 1.77E-02 AXIN2,IL17A coenzyme Q10 chemical drug 1.77E-02 NOS3,PPARA cilazapril chemical drug 1.77E-02 COL3A1,NPPA 5-fluorouracil chemical drug -0.608 1.81E-02 BNIP3,CAPNS1,CDK2,CES2,CFLAR,CLU,COPS8,COX6C,EIF2S2,FGFR2,PRC1,PSME1,PTGES3,RPL19,RPL21,RPL35,SMS,SRSF2,SSR4,XPOT miR-4520a-3p (miRNAs w/seed UGGACAG) mature microRNA 0.715 1.83E-02 CADM3,GRSF1,KCNQ3,MAPKAPK2,NEDD4L,RASL12,RHEB,SIKE1,SLC25A15,ZNF572 miR-3622a-3p (and other miRNAs w/seed CACCUGA) mature microRNA -0.184 1.83E-02 AOC3,ATAD1,BOK,CCDC149,CMTM4,NUDT11,PLEKHF2,SIKE1,TMEM30A,TOPORS miR-3136-5p (and other miRNAs w/seed UGACUGA) mature microRNA -0.835 1.83E-02 ANKRD22,CMTM4,CRLF3,DNAJC10,DRD5,ICOS,KIAA1432,KLHL5,NADSYN1,SERP1 miR-718 (miRNAs w/seed UUCCGCC) mature microRNA 0.640 1.88E-02 BOK,FRMD8,KIF3B,PARP16,SLC6A2,VPS26A miR-3673 (miRNAs w/seed UGGAAUG) mature microRNA -1.387 1.89E-02 ALG2,FPGT,KIAA1432,SERP1,SRXN1 miR-452-5p (and other miRNAs w/seed ACUGUUU) mature microRNA -1.400 1.89E-02 CASD1,LIG4,MTMR6,PNN,STAM2 miR-3082-5p (and other miRNAs w/seed ACAGAGU) mature microRNA -0.397 1.91E-02 AKAP5,C17orf75,C5orf30,C8orf37,FAM96A,GORAB,PDZK1,TRAF5 miR-4733-5p (miRNAs w/seed AUCCCAA) mature microRNA -1.420 1.91E-02 C5orf30,CNGA1,DPAGT1,GRSF1,MRPL43,RACGAP1,RDH14,ZNF238 streptozocin chemical drug -0.041 1.92E-02 ALDH3A2,ATP1A1,CBS,CLU,COL3A1,DRD1,FGFR4,GHRL,HSD11B2,HSPD1,INSIG2,NOS3,NPPA,PDGFRA,PPARD,SLC25A11,SLC6A2,SOD3 miR-3547 (and other miRNAs w/seed GAGCACC) mature microRNA -1.060 1.92E-02 CMPK1,COL11A1,COL22A1,COL3A1,GRPEL2,HPS1,IL4R,MAPKAPK2,MRPL46,OSBPL11,RIC3,RPL13,SCML4,ST6GAL1,TBC1D7,TOMM20,VAMP4,WDR43 Angiotensin II receptor type 1 group 1.99E-02 ATP1A1,HCRT,NOS3,TIMP1 PKNOX1 transcription regulator 1.99E-02 COL5A2,HOXB2,MYBBP1A,PTPN11 E2F1 transcription regulator -0.813 2.01E-02 BNIP3,BOK,CCNE2,CDK2,CFLAR,COL10A1,COL2A1,COPS8,CSDE1,FGFR2,FGFR3,HLTF,HMGB1,MAD2L1,MAPK14,MCM5,PPP1R8,RACGAP1,RB1,RHOBTB2,RYBP,SMC4,SRSF1,SRSF2,STAM,TRAP1,TXNL1,UGDH,WWOX E2F4 transcription regulator 2.07E-02 BNIP3,CCNE2,CDK2,CENPE,CSDE1,FPGT,HLTF,HMGB1,KHDRBS1,MAD2L1,MCM5,NASP,OIP5,PPP1R8,PRC1,RB1,SMC4,SRSF2,STAM,WDR76 4-hydroxytamoxifen chemical drug 0.137 2.09E-02 CLU,CNBP,DDX21,ESR1,HDGF,MAPK14,PDZK1,PTPN11,RB1,RHOBTB2,TMOD1 APC enzyme 2.09E-02 AXIN2,CHGA,CLU,FH,GHRL,IL17A,PPARA,PPARD,PTGS1,SUCLG2,TIMP1 mir-22 microRNA 2.11E-02 ERAL1,ESR1,MYCBP cytochalasin D chemical toxicant 0.651 2.12E-02 CNP,COL2A1,HOXB2,NOS3,RPLP0,SLC9A5 miR-520a-5p (and other miRNAs w/seed UCCAGAG) mature microRNA -1.621 2.15E-02 ASUN,CD46,CDC73,CEP19,EXOC6,KIAA1033,KLHL5,MRPS25,NUPL1,RB1,TLR7,USP5,UTP15,VMA21,ZNF182 miR-875-3p (miRNAs w/seed CUGGAAA) mature microRNA 0.342 2.15E-02 EGLN3,MTMR6,NDFIP2,PPIP5K2,RNF20,SPATA5,ZYX KAT5 transcription regulator 0.000 2.38E-02 ERCC1,HSPD1,MAD2L1,NPPA,SRSF2,TDG miR-223-3p (miRNAs w/seed GUCAGUU) mature microRNA -1.259 2.47E-02 ACSL3,ANKRD40,ARHGAP5,C17orf75,CHUK,CLSTN1,CLYBL,COPS8,CREBZF,CYP4V2,FGFR2,KPNA3,NAA50,NFIB,OTUD4,PRDM1,RCN2,RYBP,SELT,SEPT2,SLC8A1,SLMO2,SMOC1,SYNCRIP,TMEM64,WDR43,XPR1,ZNF238,ZZZ3 26s Proteasome complex -0.854 2.49E-02 ESR1,HSD3B2,MPL,RB1,SFTPA1,SKIL,SMAD2,UBE2I miR-4717-3p (miRNAs w/seed CACAUGG) mature microRNA -1.193 2.51E-02 ABCA1,CMTM4,GEMIN4,IFNAR1,MAGI1,MCMBP,PEX2,PRKD3,PUS7L miR-218-5p (and other miRNAs w/seed UGUGCUU) mature microRNA -1.667 2.58E-02 ACTN1,ADO,ANKRD40,ARHGAP5,ARMC8,BAHD1,C14orf129,C5orf15,C7orf41,CACNB4,CAMKK1,CDCA7L,CNN1,COL10A1,CREBZF,CSDE1,CTDSPL,CUL3,DDX5,EGLN3,EID3,FAM3C,GATC,GNAO1,HMGB1,IDH3A,IMPAD1,KCNQ3,LAMP2,LGALSL,MARK2,MBLAC2,MED17,N4BP1,NUP50,ODZ3,OLA1,PAPOLA,PCMTD2,PDGFRA,PLEKHF2,PPP1CB,PRMT3,PTP4A1,PTPN11,RBM18,RELN,RIC3,RICTOR,RNF103,RNF219,RYBP,SERP1,SLC12A2,SPAG9,SSR1,STAM2,STK38,SV2A,THTPA,TMEM178A,TMEM68,TMX1,TNIK,TRAF5,TSHZ2,WIPF2,ZNF37A,ZNFX1 HSF1 transcription regulator 0.000 2.66E-02 BCL10,BMP7,CCT8,CFLAR,CLU,CSF3,CSRP2,FGF1,HMGB1,HSP90AA1,HSPD1,KNTC1,MADCAM1,SGOL2,ST13 COBRA1 other 2.70E-02 MAD2L1,RPLP0,RPS3 SPRY1 other 2.70E-02 AXIN2,FGFR3,LMO4 CAV1 transmembrane receptor -0.555 2.75E-02 BLOC1S6,CRNKL1,CSN2,ESR1,KRT8,NEDD4L,NOS3,NPPA,RALA,SLC12A2,SPAG9,TXNL4A Insulin group -1.358 2.80E-02 ACADM,ADRB3,ARG2,ATP5G2,CDK2,CDK8,CFLAR,CYP1A1,FER,FGFR4,GCLC,HSD3B2,LIPE,NOS3,NR4A2,PLB1,PPARA,PPARD,PTPN11,RDH5,SLC25A11,SLC38A3,SQLE,SRD5A1 FABP4 transporter 1.000 2.81E-02 ABCA1,LIPE,PPARA,PPARD NF1 other 2.81E-02 CBS,NPPA,RPL21,RPS19 ILX-23-7553 chemical drug 2.84E-02 CLU,NPPA GPR39 G-protein coupled receptor 2.84E-02 CLU,LIPE 7S NGF complex 2.84E-02 CLU,GCLC HMGB2 transcription regulator 2.84E-02 COL10A1,COL2A1 PSAP other 2.84E-02 BIRC3,ESR1 itraconazole chemical drug 2.84E-02 CAMP,CYP1A1 2,3,7,8-tetrachlorodibenzofuran chemical toxicant 2.84E-02 CYP1A1,ESR1 Hg2+ chemical - endogenous non-mammalian 2.84E-02 CYP1A1,FXYD2 mercury chemical toxicant 2.84E-02 ESR1,PLAT miR-3942-3p (miRNAs w/seed UUCAGAU) mature microRNA -1.432 2.85E-02 ATG4C,AZIN1,CSGALNACT2,HMGB1,PLEKHF2 miR-512-3p (and other miRNAs w/seed AGUGCUG) mature microRNA -0.373 2.88E-02 AKAP10,CFLAR,CSGALNACT2,DHX40,IVNS1ABP,PPARA,USP3 miR-4502 (miRNAs w/seed CUGAUGA) mature microRNA -0.186 2.95E-02 GORAB,GRPEL2,KIAA1033,PIAS2,STAM2,ZNF37A miR-193a-3p (and other miRNAs w/seed ACUGGCC) mature microRNA 0.596 2.98E-02 C1orf122,CLSTN1,CNBP,CRTC1,ESR1,FARP1,FGF1,FLI1,GNAO1,GSR,ICOS,KDM5C,LAMP2,LOXL4,MAP3K3,MARK2,N4BP3,NEDD4L,NUP50,OSMR,PARP16,RAPGEF6,RGL1,SMG6,SRSF2,TBC1D20,TMEM30A,TREML2 miR-10a-5p (and other miRNAs w/seed ACCCUGU) mature microRNA -1.293 2.98E-02 ARG2,ARIH2,CEP350,CNN1,CNST,CRLF3,CTDSPL,KLC2,LGALSL,MBLAC2,MCMBP,MYCBP,NCOA6,NUP50,PISD,PPARA,RB1CC1,RHOBTB2,SMAD2,SMURF1,SOBP,SPAG9,SRSF1,TMOD1,TPM4,UBE2I,YAF2,ZNF608 miR-663b (miRNAs w/seed GUGGCCC) mature microRNA -1.587 3.02E-02 AGPAT2,BAHD1,BRD8,C3orf45,CACFD1,CACNA1A,CCDC134,CIC,CRHR2,CRTC1,CYLD,CYP1A1,DPAGT1,FAM208A,GALNTL1,GPIHBP1,MAPKAPK2,PDGFRA,RAB38,RDH11,RNF123,SAMD11,SLC38A3,TBC1D22A,TMOD1,TTC5,UNC45B,VSTM4,WNT11,ZNF74 miR-4802-3p (miRNAs w/seed ACAUGGA) mature microRNA 0.217 3.09E-02 BAHD1,CHMP3,FECH,LAMP2,PRUNE,RAB11A,RNF19A,RYBP,SGOL1,TTC33,UTP15 miR-4686 (miRNAs w/seed AUCUGCU) mature microRNA -1.664 3.15E-02 CLINT1,CYBRD1,IREB2,PDZK1,RBM43,SELT,ZBTB1 miR-660-5p (miRNAs w/seed ACCCAUU) mature microRNA -0.863 3.19E-02 AOC3,COG6,CYP4V2,PFKFB2,RNF219,SMOC1,YAF2,ZNF326 ritonavir chemical drug 3.24E-02 AXIN2,BMP1,CDCA7L,CEP70,CYP1A1,IFRD1,LIPE,NOS3,PNRC2,RACGAP1,RDH11,SQLE,TSN miR-18a-5p (and other miRNAs w/seed AAGGUGC) mature microRNA -1.937 3.25E-02 C5orf30,CDK2,CTDSPL,ESR1,FAM166B,FAM3C,FGF1,FGFR3,GCLC,GIGYF1,GNPDA2,HMGCS1,HSF2,KIF3B,LMO4,MARCH5,NAA50,NCOA2,NR3C1,ODZ3,PTP4A3,SMAD2,STAM2,SYNCRIP,TMEM230,VMA21,ZCCHC3 nicotinic acid chemical - endogenous mammalian 0.277 3.28E-02 ABCA1,HMGB1,LIPE,PPARA paroxetine chemical drug 0.000 3.28E-02 ABCA1,BNIP3,INSIG2,RBM12B CaMKII complex 3.36E-02 BIRC3,NOS3,SYNGAP1 ZIC3 transcription regulator 3.36E-02 KLK1,NPPA,PDGFRA SIM2 transcription regulator 3.36E-02 BNIP3,CSN2,ICT1 miR-548d-3p (and other miRNAs w/seed AAAAACC) mature microRNA 3.36E-02 FUBP3,PTGR2,SGOL2 miR-4504 (miRNAs w/seed GUGACAA) mature microRNA -1.091 3.44E-02 CLU,EXOC6,NIPSNAP3A,OSMR,SLC33A1,SNAP23,STAM2 miR-3181 (miRNAs w/seed UCGGGCC) mature microRNA -0.108 3.45E-02 APBB2,CAMKK1,CLSTN1,IDH3A,L1CAM,LIPE,SAE1,SAP30L miR-3929 (and other miRNAs w/seed AGGCUGA) mature microRNA -0.149 3.47E-02 CCDC132,LPIN2,OTUD4,PDP2,PRUNE,SDAD1,TBC1D20,TOMM22,VTA1,YAF2 miR-4314 (miRNAs w/seed UCUGGGA) mature microRNA -0.835 3.47E-02 ACSS1,BAHD1,C7orf57,CD58,CNGB1,COQ10A,HTR4,MTHFD1L,NAP1L5,NR3C1,OSBPL11,TRAF5,UNC45B,VSTM4,WHSC1L1,ZNF146,ZZZ3 miR-4437 (miRNAs w/seed GGGCUCA) mature microRNA -0.499 3.67E-02 ABCB8,ACADM,ALPK3,BCL6B,BIRC3,BOK,CABP4,CACNB1,CFLAR,CHAC1,CMTM3,DCAF17,FGFR1OP,HPS1,HSD11B2,IFRD1,MAVS,PDCD1,PRDM1,RNF11,SART1,SGOL2,ST6GAL1,STAMBP,UBE2D2,VPS45 SPDEF transcription regulator -0.378 3.73E-02 BIRC3,COL4A2,COL5A2,ITGA5,ITGA6,LAMB2,SFTPA1,SMAD2 miR-4733-3p (miRNAs w/seed CACCAGG) mature microRNA -1.211 3.75E-02 ALPK3,BMP1,C11orf31,COG6,GPIHBP1,RALA,RIC3,RNF185,RPL28,RWDD4,TIMM10,TMEM168,TRAF5,UBE3B,ZZZ3 SYVN1 transporter -0.277 3.80E-02 ACSL3,ATP1A1,CD46,CTPS1,GGCX,GPRC5A,ITGA6,L1CAM,NDFIP2,PPP1R15B,SNAP23,USP5,ZNF281 ochratoxin A chemical toxicant -0.211 3.80E-02 COL3A1,GCLC,NOS3,TIMP1 IL2 cytokine 0.690 3.87E-02 ARHGDIA,BIRC3,CARD10,CCNE2,CCNG2,CD46,CD58,CDK2,CFLAR,CSF3,CSN2,CTLA4,CTPS1,CYP1A1,DARS2,DDX21,ELF1,GCNT1,HSPD1,ICOS,IFNGR2,IL17A,IL17RB,IL4R,LTA,MAPKAPK2,NAB2,PDCD1,POLR1B,POLR2D,PRDM1,RPL21,SNAP23,STAM,TIMP1,TRAF5 GH1 growth factor -0.282 3.93E-02 ADRB3,ATP5G2,CLU,COL3A1,CROT,CSN2,GCLC,GHRL,IL4R,LIPE,NPPA,PPARA,PRDX3,RAD23B,SIRT1,SMARCA4,UGDH,XRCC1 miR-499-3p (and other miRNAs w/seed ACAUCAC) mature microRNA -0.000 4.01E-02 HNRPDL,IVNS1ABP,MAGI1,MUT,PSMG4,STIM2,TMX1,UBE2E3 miR-4257 (miRNAs w/seed CAGAGGU) mature microRNA -0.113 4.01E-02 ADSS,CEP350,PPIE,SLC25A17,SPRYD7,ST13,TOMM70A,UBA6 miR-516a-5p (miRNAs w/seed UCUCGAG) mature microRNA 0.200 4.07E-02 MASP2,PIK3R4,SCFD2,SMAD2,SPPL3 miR-4682 (miRNAs w/seed CUGAGUU) mature microRNA -1.446 4.07E-02 CAMLG,FPGT,METTL14,SSR1,STAMBP miR-549a (miRNAs w/seed GACAACU) mature microRNA -1.664 4.07E-02 FASTKD2,MBLAC2,PNRC2,PRMT3,SERP1,TTC33,VPS37A DOT1L phosphatase 4.10E-02 RPL19,RPLP0,RPS2 mir-122 microRNA 4.10E-02 MAP3K12,MAP3K3,RAD21 ACTB other 4.10E-02 Cald1,MYLK2,RACGAP1 acetaldehyde chemical - endogenous mammalian 4.10E-02 PPARA,SIRT1,TIMP1 HOXB1 transcription regulator 4.11E-02 COL5A2,HOXB2 miR-3149 (miRNAs w/seed UUGUAUG) mature microRNA 4.11E-02 FKBP7,PNRC1 PAX1 transcription regulator 4.11E-02 COL2A1,PDGFRA ADIPOR2 other 4.11E-02 ACOX1,PPARA AIP transcription regulator 4.11E-02 CYP1A1,PPARA CAMK2G kinase 4.11E-02 BIRC3,NPPA SLC6A2 transporter 4.11E-02 CLSTN1,SLC6A2 CCDC80 other 4.11E-02 AXIN2,BCLAF1 ZYX other 4.11E-02 Cald1,ITGA5 muromonab-CD3 biologic drug 4.11E-02 ICOS,IL17A paraquat chemical toxicant -0.986 4.16E-02 BNIP3,CCL19,GCLC,GSR,LPIN2,MARCH9,NFIB,SIRT1,SLC8A1,SOD3,TIMP1 MAPK9 kinase -0.798 4.20E-02 BIRC3,BMP1,CYP1A1,FXYD2,HDC,LTA,NOS3,PLAT,PPARA,RAD23B,RPSA,SOD3,ZYX AHR ligand-dependent nuclear receptor 0.361 4.29E-02 ACOX1,ACTN1,ARG2,CBR3,CCNG2,CDK2,COL11A1,COL14A1,COL3A1,COL4A2,COL5A2,CYP1A1,ESR1,FGFR2,HMGB1,HSP90AA1,IL17A,INSIG2,ITGA5,ITGA6,ITGA7,LYST,PDGFRA,PLAT,SIRT1 miR-342-3p (miRNAs w/seed CUCACAC) mature microRNA -1.479 4.32E-02 AAMP,ANKLE2,APBB2,BMP7,BTBD7,DDX50,ETAA1,FAM208A,GOSR1,HERC4,IBTK,KIAA1033,KIAA1715,MAGIX,MTMR6,PDGFRA,PLAA,PRPF40B,RAD23B,RICTOR,SPAG9,SRSF3,SV2A,TDG,UBE2D2,UXS1,ZZZ3 miR-4720-3p (miRNAs w/seed GCUUAAG) mature microRNA -1.969 4.37E-02 ACOT13,CSN2,IGF2BP3,PUS7L PTGES enzyme 4.37E-02 CDK5,ITGA6,NOS3,NPPA,PPA1,RPS19 PPARA ligand-dependent nuclear receptor -0.662 4.43E-02 ABCA1,ACADM,ACOX1,ALDH3A2,ARHGDIA,CDK2,CROT,CSN2,CYP1A1,ENDOG,HMGCS1,Hmgn1,HSD17B4,HSD3B2,INSIG2,KHK,KIF20A,KRT8,MAD2L1,MASP2,NPPA,PPA1,PPARA,PPARD,PRC1,PTGR1,RETSAT,SARDH,SMC4,SQLE,TDG miR-874-3p (and other miRNAs w/seed UGCCCUG) mature microRNA -1.088 4.43E-02 ABAT,ALG1,CNP,DONSON,EPB49,ESR1,FARP1,FGF1,GGACT,GGCX,GORAB,KIAA1432,KIF3B,LDB1,LMO4,MADCAM1,MARCH9,MBLAC2,NUPL1,PAAF1,PLD3,PRDM1,RAB11FIP5,RUNDC3A,SCFD2,SLC46A1,TOMM20,TUBD1,USP8,VGLL4,ZNF37A miR-767 (and other miRNAs w/seed GCACCAU) mature microRNA -0.822 4.45E-02 ABAT,ANP32E,COL3A1,CSDE1,DDHD2,DDX5,HMGCS1,KRT79,NAP1L5,STK19 YY1 transcription regulator 4.47E-02 CDCA3,CENPE,CLU,COL10A1,CSN2,GTF2A1,KIF20A,MAD2L1,MATR3,MCM5,NR3C1,PDGFRA,PNRC2,POLK,PPP4R2,PRC1,RAD21,SRSF1,SYNCRIP,TGM2 miR-1301 (and other miRNAs w/seed UGCAGCU) mature microRNA -0.300 4.48E-02 ACSL3,ARIH2,CD46,DDHD2,DGAT2,FAM174B,GPN3,MARC2,RHEB,RICTOR,SKIL,SLC33A1,SRXN1,YAF2 EGFR kinase -1.028 4.55E-02 C12orf49,CAPZA2,CCNG2,CDK2,COL3A1,COL5A2,CUL3,HDC,HSD11B2,ITGA6,NFIB,NPPA,OSMR,PLAT,PRKAR1A,PTGS1,RB1,S100A2,SERPINA3,TCOF1,TGM2 miR-4800-5p (miRNAs w/seed GUGGACC) mature microRNA 0.303 4.55E-02 ALDH7A1,ANKIB1,ARG2,AXIN1,GIGYF1,H2AFV,LAMC3,MARCH2,SGK196,SPATA5,SSR1,STX7 miR-3152-5p (miRNAs w/seed UUGCCUC) mature microRNA -1.976 4.65E-02 ARIH2,CAMLG,CCDC115,CHCHD1,CNST,GIGYF1,GNAO1,IREB2,PGGT1B,SMC4,VAMP4 miR-198 (miRNAs w/seed GUCCAGA) mature microRNA -1.573 4.79E-02 CBS,CEP350,CLMN,FAM208A,KDM5C,MAPRE2,MCTS1,MUT,POC1B,SAP30L,SLC6A2,STAT2 miR-505-3p (miRNAs w/seed GUCAACA) mature microRNA -0.645 4.81E-02 ABAT,ACOX1,AKIP1,ANKRD40,APBB2,C12orf23,CACNB4,CLSTN1,EIF2S2,FAM174B,HMGB1,HNRPDL,MAP3K3,MARCH5,MED17,MZT1,NCOA2,PIGW,PIGY,RBM43,SAV1,TIMM10,UBE3B NREP other 4.92E-02 COL3A1,ITGA5,PDGFRA SPTLC2 enzyme 4.92E-02 NPPA,SPTLC1,TIMP1 paricalcitol chemical drug 4.92E-02 COL3A1,NPPA,TIMP1 arsenic chemical toxicant 4.92E-02 BIRC3,ESR1,NOS3 CRX transcription regulator 4.97E-02 ARR3,CACNA1H,CNGA1,SAMD11 MKL1 transcription regulator -1.960 2.19E-01 CAMP,CNN1,CNN2,FLI1,ITGA6,MPL,NPPA,RAB27B SMAD2 transcription regulator 1.982 2.61E-01 CCNG2,COL2A1,NOS3,SKIL,SMAD2 fluoxetine chemical drug 1.886 3.05E-01 HDAC2,HTR4,NR3C1,SERPINA3,ZNF326 INHA growth factor -1.890 3.64E-01 CFLAR,CNN1,COL3A1,FGFR4,KRT79,KRT8,LAMC3 CCND1 other 1.951 3.75E-01 CCNE2,CDCA7L,CDK2,COL5A2,CPNE3,DONSON,KIF20A,LIN7B,MBLAC2,MELK,MFSD6,RB1,RFC5,ZNF462 fenretinide chemical drug 1.982 3.78E-01 CFLAR,ERCC1,MAPK6,XPO1 RB1 transcription regulator -1.969 4.43E-01 BNIP3,CCNE2,CDCA7L,CDK2,CSN2,DONSON,FANCL,GPRC5A,H1F0,MCM5,MCMBP,MELK,PRKAR1A,RB1,RECQL4 Interferon alpha group 1.988 1.00E00 CCL19,EMID1,IFNAR1,IL4R,IL7,PLAT,RB1,STAT2,TBC1D10A,TLR7,TRIM5 decitabine chemical drug 1.987 1.00E00 ABO,BIRC3,BNIP3,CCNG2,CDH16,COL3A1,CYP1A1,DMBT1,ESR1,FECH,FGFR3,KRT8,NOS3,RB1,RELN,S100A2,SSTR2,STK3,TNFRSF25,ZBTB1 CEBPA transcription regulator 1.923 1.00E00 ADRB3,ARG2,CAMP,COL10A1,CSF3,CSN2,DDX21,DGAT2,MAPKAPK2,NR4A2,PPARA,PPARD,PTGS1,SCAP,SFTPA1,TANK,UBE2I IFNB1 cytokine 1.913 1.00E00 CLSTN1,CYP1A1,GLIS2,HMGCS1,IFNAR1,PDCD1,SQLE,STAT2,TLR7 PPARGC1A transcription regulator 1.903 1.00E00 ACADM,ACOX1,CYP1A1,DLAT,IDH3A,PPARA,PRDX3 HOXA10 transcription regulator -1.765 1.00E00 AIMP2,CDH16,COL3A1,EMX2,HSP90AA1,IRX3,REM1,ST6GAL1,YWHAG ACOX1 enzyme -1.912 1.00E00 ACADM,ACOX1,COL4A2,HSD3B2,KRT8,PALMD,PIPOX IL4 cytokine -1.978 1.00E00 ACOT9,ACOX1,ALG3,ARG2,BNIP3,CD58,CLIP1,CMAHP,CSF3,CSN2,DARS2,ICOS,IFNAR1,IL17A,IL17RB,IL4R,LAMP2,LGALSL,LIG4,LTA,MCM5,NAB2,PDCD1,PRDM1,PRR3,PSME1,STAT2,TGM2,TIMP1,ZZZ3 RUNX2 transcription regulator -1.980 1.00E00 COL11A1,FGFR2,SGPP1,TIMP1 rottlerin chemical toxicant -1.980 1.00E00 ABCA1,ATP6AP2,BIRC3,COL3A1 ABCB8,ACOT13,ACOX1,ACTN1,ADSS,AGTPBP1,ARG2,ARMC8,ASUN,ATG4C,AXIN2,BCLAF1,BLOC1S6,BMP7,BNIP1,BRD8,C11orf58,C12orf49,CAPZA2,CBR3,CBS,CCDC115,CCNE2,CCNG2,CCNH,CCT8,CD46,CDCA7L,CDK2,CDK5,CDK8,CEP19,CES2,CLDN12,CLPX,CLYBL,CNBP,CNOT3,COPB1,COPS8,CROT,CRY1,CUL5,CYB561D2,CYLD,CYP1A1,DDOST,DDX10,DPAGT1,EID1,ELMOD3,ELP2,FASTKD2,FBP1,FBXL7,FDX1,FH,GGCX,GSTM4,HMGB1,HSD17B4,IFNAR1,ITGA6,IVNS1ABP,KDM5C,KHDRBS1,KIF20A,KIF3B,KLC4,KRT8,LATS1,LDB1,MADCAM1,MAP3K3,MFSD1,MICU1,MRPL43,MRPL44,MRPL46,MRPL53,MUT,NAA50,NARS2,NAT10,NCK1,NECAP1,NOC3L,NOL7,NSL1,NUDT11,NUP54,OSBPL11,OSMR,P2RY14,PAAF1,PALMD,PAPOLA,PARP4,PDZK1,PFDN6,PGGT1B,PGM3,PLAA,POLR1B,PPARA,PPARD,PPIP5K2,PPP1R15B,PRMT7,PRR3,PTGES3,PTPN11,RAB11A,RAB18,RAB2A,RABAC1,RASL12,RBM18,RDH11,RFC5,RNF40,RPL18A,RSL24D1,SAP30L,SEC11C,SEC23IP,SERPINA3,SF3B1,SGCE,SLC33A1,SLC35A3,SLMO2,SNAP23,SNAPC1,SNX5,SPATA5L1,SRSF1,SRSF11,SRSF2,ST13,STAM,STAM2,STAMBP,STK19,STRAP,STX17,TAF6,TBC1D10A,TDRKH,TERF2IP,THOC3,TMEM101,TMEM208,TMEM30A,TSN,TXNL1,UBE2M,USP5,UTP18,WASL,WBP4,WNT11,XPO1,XPR1,ZCCHC9,ZNF146,ZNF175,ZNF189,ZNF281