Dataset S3.Xlsx

Supplementary Table S4. Functionally enriched Gene Ontology biological processes in combination treatment of ABT-263 and YM-155 compared to other samples (P <0.05). Term P -value Group P -value Term P - Group P - % Associated No. of Cluster GO_id GO_term corrected with corrected with Associated genes value value genes genes Bonferroni Bonferroni [ABAT, ADAM8, ALS2CL, AMH, APOE, ARC, ARHGAP40, ARHGDIG, ARHGEF1, ARHGEF4, ATP2B4, ATP6V1C2, BBC3, BCL3, BMPR1B, C10orf54, CARD10, CHAC1, CHD5, CHGA, CSF1R, DDIT4, DIRAS1, DMPK, DOT1L, DRAXIN, DRD2, DRD4, DUSP2, DUSP8, DVL1, ECM1, EDAR, EGFR, EPHA2, EPS8L1, ERN1, FAIM2, FGF20, FGF21, FGFR3, FSTL3, GDF15, GLIS2, GPC1, GPR55, GPSM1, GRB10, HCLS1, HIC1, HMHA1, IGFBP1, IGFBP3, IGSF9B, INHBE, IRF7, IRS2, ITGA5, JAG2, KCNN4, KIF26A, KMT2D, regulation of signal #1 GO:0009966 13.0E-9 6.7E-6 900.0E-12 6.3E-9 4.11 116.00 KREMEN2, LGR6, LIF, LRP1, LTBP4, MAPK8IP2, transduction MAPK8IP3, MBD3, MMRN2, MNT, MUC20, NKX2- 5, NOTCH1, NR1D1, NTSR1, OBSCN, PDGFB, PDGFRB, PLEKHG4, PLEKHG5, PLXNA1, PLXNB1, PRKCE, PTK2B, PTP4A3, RGS16, RHBDF1, RIMS2, SCG2, SCRT2, SESN2, SEZ6, SEZ6L2, SH2B2, SH3TC2, SLIT1, SOCS1, SOCS3, SPHK1, SPRED3, SYDE2, TMEM88, TNFRSF25, TNFRSF6B, TNXB, TRIB3, TRIM15, TRIP6, UNC5B, VASN, VEGFA, WNT2B, WTIP, ZC3H3]

[ABAT, ADAM8, AMH, ARC, ATP6V1C2, BBC3, BMPR1B, C10orf54, CARD10, CHD5, CHGA, CHRNB2, CSF1R, DIRAS1, DRD2, DRD4, DVL1, ECM1, EDAR, EGFR, ERN1, FGF20, FGF21, FGFR3, FLNB, GDF15, GPR55, GRB10, HCLS1, HIC1, IGFBP3, IGSF9B, INHBE, IRF7, IRS2, positive regulation of cell ITGA2, ITGA5, JAG2, KCNN4, KMT2D, LGR6, LIF, #1 GO:0010647 3.4E-6 1.6E-3 900.0E-12 6.3E-9 4.33 71.00 communication MAPK8IP2, MAPK8IP3, MUC20, NOTCH1, NTSR1, PDGFB, PDGFRB, PLEKHG5, PLXNA1, PLXNB1, PRKCE, PTK2B, RIMS2, SH2B2, SNAP25, SOCS1, SOCS3, SPHK1, SYT12, TNFRSF25, TNFRSF6B, TRIM15, TRIP6, ULK1, UNC13A, UNC5B, VEGFA, WNT2B, ZC3H3] [ABAT, ADAM8, AMH, ARC, ATP6V1C2, BBC3, BMPR1B, C10orf54, CARD10, CHD5, CHGA, CSF1R, DIRAS1, DRD2, DRD4, DVL1, ECM1, EDAR, EGFR, ERN1, FGF20, FGF21, FGFR3, GDF15, GPR55, GRB10, HCLS1, HIC1, IGFBP3, IGSF9B, INHBE, IRF7, ITGA5, JAG2, KCNN4, positive regulation of signal #1 GO:0009967 21.0E-6 9.9E-3 900.0E-12 6.3E-9 4.28 63.00 KMT2D, LGR6, LIF, MAPK8IP2, MAPK8IP3, transduction MUC20, NOTCH1, NTSR1, PDGFB, PDGFRB, PLEKHG5, PLXNA1, PLXNB1, PRKCE, PTK2B, RIMS2, SH2B2, SOCS1, SOCS3, SPHK1, TNFRSF25, TNFRSF6B, TRIM15, TRIP6, UNC5B, VEGFA, WNT2B, ZC3H3]

[ADAM8, ADCY7, ADORA2A, AMH, APOE, ATP2B4, AVPR2, CARD10, CHGA, CSF1R, DIRAS1, DRD2, DRD4, DVL1, EDAR, EGFR, ERN1, FGF20, FGF21, FGFR3, FLNB, GDF15, positive regulation of GPR55, GRB10, HCLS1, IGFBP3, INHBE, ITGA2, #1 GO:0045937 90.0E-6 40.0E-3 900.0E-12 6.3E-9 4.40 49.00 phosphate metabolic process ITGA5, LIF, MAPK8IP2, MAPK8IP3, MUC20, NPPC, NTSR1, P2RY11, PDGFB, PDGFRB, PKD1, PRKCE, PTK2B, RAPGEF3, SOCS1, SOCS3, SPHK1, TNFRSF25, TNFRSF6B, TNK2, VEGFA]

[ADAM8, AMH, ANGPT2, APOE, ARC, CAMK1D, CELSR3, CHGA, CSF1R, DCHS1, DDIT4, DRD2, ECM1, EGFR, EGR3, EPHA2, EPHA3, FAM83H, IFITM1, IGFBP3, IL16, IRS2, ITGA2, ITGA5, JAG2, L1CAM, LAMA5, LGR6, LOXL2, LRP1, MDGA1, MMRN2, NOTCH1, PDGFB, PDGFRB, PLEKHG5, #2 GO:0016477 cell migration 2.8E-6 1.4E-3 1.3E-6 6.6E-6 4.69 59.00 PLXNA1, PLXNA3, PLXNB1, PLXNB3, PRKCE, PTK2B, PTP4A3, RAPGEF3, RHBDF1, RLTPR, SCG2, SCRT2, SEMA3B, SEMA4A, SLC7A11, SLIT1, SPHK1, THBD, TIE1, TNK2, TRIP6, TSPO, VEGFA] [ADAM8, ANGPT2, APOE, CAMK1D, CHGA, CSF1R, DRD2, ECM1, EGFR, EPHA2, FAM83H, IFITM1, IGFBP3, IRS2, ITGA2, ITGA5, JAG2, LAMA5, LGR6, LRP1, MMRN2, NOTCH1, PDGFB, #2 GO:0030334 regulation of cell migration 5.5E-6 2.6E-3 1.3E-6 6.6E-6 5.48 39.00 PDGFRB, PLXNA1, PLXNA3, PLXNB1, PLXNB3, PRKCE, PTK2B, RAPGEF3, RLTPR, SCRT2, SEMA3B, SEMA4A, SPHK1, TIE1, TRIP6, VEGFA]

[ADAM8, ADM2, ANGPT2, APOE, ECM1, EGR3, EPHA2, HSPG2, ITGA5, JUNB, LAMA5, LIF, LOXL2, LRP1, LYL1, MMRN2, NKX2-5, NOTCH1, #2 GO:0001568 blood vessel development 52.0E-6 24.0E-3 1.3E-6 6.6E-6 5.34 33.00 NOTCH3, PDGFB, PDGFRB, PKD1, PLXNA1, PTK2B, RAPGEF3, SCG2, SEMA4A, SOCS3, SPHK1, TIE1, UNC5B, VEGFA, WNT7B] [ANGPT2, APOE, EGR3, EPHA2, ITGA2, LOXL2, MMRN2, NOTCH1, PDGFB, PLEKHG5, PLXNA1, #2 GO:0010631 epithelial cell migration 110.0E-6 49.0E-3 1.3E-6 6.6E-6 7.08 17.00 PRKCE, PTK2B, PTP4A3, SCG2, SEMA4A, VEGFA] [ADAM8, ADM2, ANGPT2, APOE, ECM1, EGR3, EPHA2, HSPG2, ITGA5, JUNB, LAMA5, LIF, LOXL2, LRP1, MMRN2, NKX2-5, NOTCH1, #2 GO:0048514 blood vessel morphogenesis 83.0E-6 38.0E-3 1.3E-6 6.6E-6 5.47 29.00 NOTCH3, PDGFRB, PLXNA1, PTK2B, RAPGEF3, SCG2, SEMA4A, SPHK1, TIE1, UNC5B, VEGFA, WNT7B] [ANGPT2, APOE, EGR3, EPHA2, LOXL2, #2 GO:0043542 endothelial cell migration 23.0E-6 10.0E-3 1.3E-6 6.6E-6 8.82 15.00 MMRN2, NOTCH1, PDGFB, PLEKHG5, PLXNA1, PTK2B, PTP4A3, SCG2, SEMA4A, VEGFA] [AGRN, AMH, ANGPT2, APOE, ARHGEF1, ATP2B4, BMPR1B, BRSK2, CAMK1D, CEBPA, CELSR3, CHD5, CHRNB2, CSF1R, DFNB31, DNASE1L2, DRAXIN, DRD2, DVL1, EGR2, EPHA2, EPHA3, FA2H, FLNB, FLNC, GDF15, GPC1, HDAC10, HSF4, INHBE, JAG2, KIF26A, KMT2D, L1CAM, LAMA5, LAMC3, LIF, LOXL2, LRFN4, LRP1, LTK, MAP1B, MAPK8IP2, MAPK8IP3, MATN1, MEI1, MFSD2A, MICALL2, #3 GO:0048468 cell development 420.0E-9 210.0E-6 12.0E-12 110.0E-12 4.26 87.00 MYH3, NKX2-5, NOTCH1, NOTCH3, NPPC, OBSCN, PAQR5, PDGFB, PDGFRB, PLXNA1, PLXNA3, PLXNB1, PLXNB3, PTK2B, PTPRS, RAPGEF3, RAPH1, RIMS2, RMRP, RNF112, SCARF1, SCRT2, SEMA3B, SEMA4A, SEZ6, SH3TC2, SLIT1, SNAP25, SPHK1, SPTBN5, TCAP, TSPO, ULK1, UNC13A, UNC13D, UNC5B, VASN, VEGFA, WNT7B]

[ABAT, ADGRL1, ADORA2A, AGRN, APOE, ARHGEF1, ATP2B4, AVPR2, BMPR1B, BOK, BRSK2, BSN, CAMK1D, CBLN1, CEBPB, CELSR3, CHAC1, CHD5, CHRNB2, CPLX2, CSF1R, DCHS1, DDIT4, DFNB31, DRAXIN, DRD2, DVL1, EGFR, EGR2, EGR3, EPHA2, EPHA3, FA2H, FAIM2, FGF20, FLNB, GLIS2, GPC1, GPSM1, HDAC10, HES4, IER2, IRS2, JAG2, KCNC1, KCNQ2, KDM6B, KIF26A, L1CAM, LAMC3, LIF, LRFN4, LRP1, LRRC24, LTK, MAFK, MAP1B, MAPK8IP2, MAPK8IP3, MBD3, MDGA1, #3 GO:0007399 nervous system development 61.0E-12 31.0E-9 12.0E-12 110.0E-12 4.66 106.00 MICALL2, MMP24, NKX2-5, NOTCH1, NOTCH3, NPPC, NRXN2, PAX5, PCDHA1, PCDHB11, PKD1, PLXNA1, PLXNA3, PLXNB1, PLXNB3, PTGS1, PTK2B, PTPRS, RAPGEF3, RAPH1, RIMS2, RMRP, RNF112, SCARF1, SCN3A, SCRT2, SEMA3B, SEMA4A, SEZ6, SEZ6L2, SH2B2, SH3TC2, SLC7A11, SLIT1, SNAP25, SPHK1, SPTBN5, THOC6, TSPO, ULK1, UNC13A, UNC5B, VEGFA, WNT2B, WNT7B] [ABAT, ADORA2A, ATP2B4, AVPR2, BOK, CBLN1, CHD5, CHRNB2, CSF1R, DDIT4, DFNB31, DRAXIN, DRD2, EGFR, EGR2, FA2H, FAIM2, FLNB, HDAC10, IRS2, KCNC1, KDM6B, central nervous system #3 GO:0007417 29.0E-6 13.0E-3 12.0E-12 110.0E-12 4.70 46.00 LAMC3, LIF, LRP1, MAPK8IP3, MBD3, MDGA1, development NOTCH1, NOTCH3, NPPC, PAX5, PKD1, PLXNA3, PTGS1, PTPRS, RAPGEF3, RMRP, SEZ6, SEZ6L2, SLC7A11, SLIT1, SPHK1, THOC6, WNT2B, WNT7B]

[ABAT, ATP2B4, AVPR2, BOK, CBLN1, CHD5, CHRNB2, CSF1R, DDIT4, DFNB31, DRAXIN, DRD2, EGFR, EGR2, FAIM2, FLNB, IRS2, KCNC1, KDM6B, LRP1, MAPK8IP3, MBD3, #3 GO:0007420 brain development 9.9E-6 4.7E-3 12.0E-12 110.0E-12 5.26 39.00 MDGA1, NOTCH1, NOTCH3, NPPC, PAX5, PLXNA3, PTGS1, PTPRS, RAPGEF3, RMRP, SEZ6, SEZ6L2, SLC7A11, SLIT1, SPHK1, WNT2B, WNT7B] [ADGRL1, AGRN, APOE, ARHGEF1, CAMK1D, CBLN1, CHRNB2, DRAXIN, DRD2, DVL1, EPHA3, L1CAM, LIF, LRP1, LRRC24, LTK, MAP1B, NKX2- regulation of nervous system 5, NOTCH1, NOTCH3, PLXNA1, PLXNA3, #3 GO:0051960 110.0E-6 49.0E-3 12.0E-12 110.0E-12 4.78 39.00 development PLXNB1, PLXNB3, PTK2B, RIMS2, RMRP, RNF112, SCARF1, SCRT2, SEMA3B, SEMA4A, SEZ6, SLIT1, SNAP25, SPHK1, TSPO, UNC13A, VEGFA] [AGRN, APOE, ARHGEF1, ATP2B4, BMPR1B, BOK, BRSK2, CAMK1D, CBLN1, CEBPB, CELSR3, CHAC1, CHD5, CHRNB2, CSF1R, DCHS1, DDIT4, DFNB31, DRAXIN, DRD2, DVL1, EGR2, EPHA2, EPHA3, FA2H, FAIM2, FGF20, GPC1, HDAC10, IER2, JAG2, KIF26A, L1CAM, LAMC3, LIF, LRFN4, LRP1, LTK, MAP1B, #3 GO:0022008 neurogenesis 17.0E-9 8.9E-6 12.0E-12 110.0E-12 4.88 74.00 MAPK8IP2, MAPK8IP3, MDGA1, MICALL2, MMP24, NKX2-5, NOTCH1, NOTCH3, NPPC, PLXNA1, PLXNA3, PLXNB1, PLXNB3, PTK2B, RAPH1, RIMS2, RMRP, RNF112, SCARF1, SCRT2, SEMA3B, SEMA4A, SEZ6, SH3TC2, SLIT1, SNAP25, SPHK1, SPTBN5, TSPO, ULK1, UNC13A, UNC5B, VEGFA, WNT2B, WNT7B] [AGRN, APOE, ARHGEF1, ATP2B4, BMPR1B, BRSK2, CAMK1D, CELSR3, CHRNB2, CSF1R, DFNB31, DRAXIN, DRD2, DVL1, EGR2, EPHA3, GPC1, KIF26A, L1CAM, LIF, LRFN4, LRP1, LTK, MAP1B, MAPK8IP2, MAPK8IP3, MICALL2, #3 GO:0048666 neuron development 6.2E-6 2.9E-3 12.0E-12 110.0E-12 4.85 50.00 NOTCH1, NPPC, PLXNA1, PLXNA3, PLXNB1, PLXNB3, PTK2B, RAPH1, RIMS2, RMRP, SCARF1, SEMA3B, SEMA4A, SEZ6, SLIT1, SNAP25, SPHK1, SPTBN5, TSPO, ULK1, UNC13A, UNC5B, VEGFA]

[AGRN, APOE, ARHGEF1, ATP2B4, BMPR1B, BRSK2, CAMK1D, CBLN1, CEBPB, CELSR3, CHD5, CHRNB2, CSF1R, DDIT4, DFNB31, DRAXIN, DRD2, DVL1, EGR2, EPHA2, EPHA3, FAIM2, FGF20, GPC1, IER2, JAG2, KIF26A, L1CAM, LIF, LRFN4, LRP1, LTK, MAP1B, MAPK8IP2, MAPK8IP3, MDGA1, MICALL2, NKX2- #3 GO:0048699 generation of neurons 800.0E-9 390.0E-6 12.0E-12 110.0E-12 4.61 66.00 5, NOTCH1, NOTCH3, NPPC, PLXNA1, PLXNA3, PLXNB1, PLXNB3, PTK2B, RAPH1, RIMS2, RMRP, RNF112, SCARF1, SCRT2, SEMA3B, SEMA4A, SEZ6, SLIT1, SNAP25, SPHK1, SPTBN5, TSPO, ULK1, UNC13A, UNC5B, VEGFA, WNT2B, WNT7B]

[APOE, ARHGEF1, BMPR1B, BRSK2, CAMK1D, CELSR3, CHRNB2, CSF1R, DRAXIN, DRD2, DVL1, EGR2, EPHA3, GPC1, KIF26A, L1CAM, LIF, LRFN4, LRP1, LTK, MAP1B, MAPK8IP2, neuron projection #3 GO:0031175 1.0E-6 500.0E-6 12.0E-12 110.0E-12 5.32 47.00 MAPK8IP3, MICALL2, NOTCH1, NPPC, PLXNA1, development PLXNA3, PLXNB1, PLXNB3, PTK2B, RAPH1, RIMS2, RMRP, SCARF1, SEMA3B, SEMA4A, SEZ6, SLIT1, SNAP25, SPHK1, SPTBN5, TSPO, ULK1, UNC13A, UNC5B, VEGFA] [ADAM8, APOE, ARHGEF1, BMPR1B, C10orf54, C14orf169, CAMK1D, CCDC85B, CEBPA, CEBPB, CHRNB2, CSF1R, DMPK, DRAXIN, DRD2, DVL1, EGR3, EPHA3, ESRRA, FSTL3, GDF15, GPC1, GPR55, HCLS1, HLA-G, HSF4, IFITM1, IGFBP3, IRF7, JUNB, L1CAM, LIF, LOXL2, LRP1, LTBP2, LTBP3, LTBP4, LTK, MAP1B, NKX2-5, NOTCH1, regulation of cell #4 GO:0045595 260.0E-9 130.0E-6 8.0E-15 89.0E-15 4.59 73.00 NOTCH3, NPPC, NR1D1, PDGFB, PLXNA1, differentiation PLXNA3, PLXNB1, PLXNB3, PTK2B, RBM24, RIMS2, RLTPR, RMRP, RNF112, SCARF1, SCRT2, SEMA3B, SEMA4A, SEZ6, SLIT1, SNAP25, SOCS3, SPHK1, TNFSF9, TRIB3, TSPO, UNC13A, UNC13D, VASN, VEGFA, WNT7B, ZFP36]

[AGRN, AMH, ANGPT2, APOE, ARHGEF1, ATP2B4, BMPR1B, BRSK2, CAMK1D, CEBPA, CELSR3, CHD5, CHRNB2, CSF1R, DFNB31, DNASE1L2, DRAXIN, DRD2, DVL1, EGR2, EPHA2, EPHA3, FA2H, FLNB, FLNC, GDF15, GPC1, HDAC10, HSF4, INHBE, JAG2, KIF26A, KMT2D, L1CAM, LAMA5, LAMC3, LIF, LOXL2, LRFN4, LRP1, LTK, MAP1B, MAPK8IP2, MAPK8IP3, MATN1, MEI1, MFSD2A, MICALL2, #4 GO:0048468 cell development 420.0E-9 210.0E-6 8.0E-15 89.0E-15 4.26 87.00 MYH3, NKX2-5, NOTCH1, NOTCH3, NPPC, OBSCN, PAQR5, PDGFB, PDGFRB, PLXNA1, PLXNA3, PLXNB1, PLXNB3, PTK2B, PTPRS, RAPGEF3, RAPH1, RIMS2, RMRP, RNF112, SCARF1, SCRT2, SEMA3B, SEMA4A, SEZ6, SH3TC2, SLIT1, SNAP25, SPHK1, SPTBN5, TCAP, TSPO, ULK1, UNC13A, UNC13D, UNC5B, VASN, VEGFA, WNT7B] [ADAM8, APOE, ARC, ARHGEF1, ATP2B4, BMPR1B, BRSK2, C15orf62, CDC42EP1, CELSR3, CHRNB2, CSF1R, DNAH1, DRAXIN, DRD2, DVL1, EGFR, EGR2, EPHA2, EPHA3, FLNB, GPC1, KIF26A, L1CAM, LAMA5, LAMC3, LIF, LOXL2, LRFN4, MAP1B, MAPK8IP2, #4 GO:0000902 cell morphogenesis 53.0E-6 24.0E-3 8.0E-15 89.0E-15 4.33 56.00 MAPK8IP3, MATN1, MICALL2, NOTCH1, NPPC, PALM2-AKAP2, PLXNA1, PLXNA3, PLXNB1, PLXNB3, PTK2B, RAPH1, RIMS2, SEMA3B, SEMA4A, SLIT1, SPTBN5, SYNE3, ULK1, UNC13A, UNC13D, UNC5B, VASN, VEGFA, WTIP]

[AGRN, APOE, ARHGEF1, C15orf62, CAMK1D, CDC42EP1, CHRNB2, DRAXIN, DVL1, EPHA2, EPHA3, EPS8L1, ITGA2, L1CAM, LIF, LRP1, LTK, regulation of cell projection #4 GO:0031344 7.2E-6 3.4E-3 8.0E-15 89.0E-15 5.69 35.00 MAP1B, PLXNA1, PLXNA3, PLXNB1, PLXNB3, organization PTK2B, RIMS2, RLTPR, RMRP, SCARF1, SEMA3B, SEMA4A, SEZ6, SLIT1, SNAP25, SPHK1, UNC13A, VEGFA] [ADAM8, APOE, BMPR1B, C10orf54, CAMK1D, CEBPA, CEBPB, CSF1R, DRD2, DVL1, EGR3, EPHA3, GDF15, GPC1, HCLS1, HLA-G, HSF4, IFITM1, IGFBP3, JUNB, L1CAM, LIF, LOXL2, positive regulation of cell #4 GO:0045597 1.0E-6 500.0E-6 8.0E-15 89.0E-15 5.32 47.00 LTBP2, LTBP3, LTK, MAP1B, NKX2-5, NOTCH1, differentiation NPPC, PLXNB1, PLXNB3, PTK2B, RIMS2, RLTPR, RMRP, RNF112, SCARF1, SEZ6, SOCS3, SPHK1, TNFSF9, TSPO, UNC13A, UNC13D, VEGFA, WNT7B]

[APOE, DRAXIN, DVL1, KMT2D, L1CAM, MAP1B, PLXNA1, PLXNA3, PLXNB1, RAPH1, RIMS2, #4 GO:0048588 developmental cell growth 15.0E-6 7.1E-3 8.0E-15 89.0E-15 8.29 17.00 SEMA3B, SEMA4A, SLIT1, ULK1, UNC13A, VEGFA] [APOE, ARHGEF1, ATP2B4, BMPR1B, BRSK2, CELSR3, CHRNB2, CSF1R, DRAXIN, DRD2, DVL1, EGR2, EPHA2, EPHA3, FLNB, GPC1, KIF26A, L1CAM, LAMA5, LAMC3, LIF, LOXL2, cell morphogenesis involved #4 GO:0000904 380.0E-9 190.0E-6 8.0E-15 89.0E-15 5.64 44.00 LRFN4, MAP1B, MAPK8IP2, MAPK8IP3, MATN1, in differentiation MICALL2, NOTCH1, NPPC, PLXNA1, PLXNA3, PLXNB1, PLXNB3, RAPH1, SEMA3B, SEMA4A, SLIT1, SPTBN5, ULK1, UNC13D, UNC5B, VASN, VEGFA]

[AGRN, APOE, C15orf62, CAMK1D, CDC42EP1, DVL1, EPHA3, EPS8L1, ITGA2, L1CAM, LIF, LTK, positive regulation of cell #4 GO:0031346 4.2E-6 2.0E-3 8.0E-15 89.0E-15 7.10 24.00 MAP1B, PLXNB1, PLXNB3, PTK2B, RIMS2, projection organization RLTPR, RMRP, SCARF1, SEZ6, SPHK1, UNC13A, VEGFA] [ADGRL1, AGRN, APOE, ARHGEF1, CAMK1D, CBLN1, CHRNB2, DRAXIN, DRD2, DVL1, EPHA3, L1CAM, LIF, LRP1, LRRC24, LTK, MAP1B, NKX2- regulation of nervous system 5, NOTCH1, NOTCH3, PLXNA1, PLXNA3, #4 GO:0051960 110.0E-6 49.0E-3 8.0E-15 89.0E-15 4.78 39.00 development PLXNB1, PLXNB3, PTK2B, RIMS2, RMRP, RNF112, SCARF1, SCRT2, SEMA3B, SEMA4A, SEZ6, SLIT1, SNAP25, SPHK1, TSPO, UNC13A, VEGFA] [ADGRL1, AGRN, APOE, CAMK1D, CBLN1, DRD2, DVL1, EPHA3, L1CAM, LIF, LRRC24, LTK, positive regulation of nervous MAP1B, NKX2-5, NOTCH1, PLXNB1, PLXNB3, #4 GO:0051962 77.0E-6 35.0E-3 8.0E-15 89.0E-15 5.63 27.00 system development PTK2B, RIMS2, RMRP, RNF112, SCARF1, SEZ6, SPHK1, TSPO, UNC13A, VEGFA]

[AGRN, APOE, ARHGEF1, ATP2B4, BMPR1B, BOK, BRSK2, CAMK1D, CBLN1, CEBPB, CELSR3, CHAC1, CHD5, CHRNB2, CSF1R, DCHS1, DDIT4, DFNB31, DRAXIN, DRD2, DVL1, EGR2, EPHA2, EPHA3, FA2H, FAIM2, FGF20, GPC1, HDAC10, IER2, JAG2, KIF26A, L1CAM, LAMC3, LIF, LRFN4, LRP1, LTK, MAP1B, #4 GO:0022008 neurogenesis 17.0E-9 8.9E-6 8.0E-15 89.0E-15 4.88 74.00 MAPK8IP2, MAPK8IP3, MDGA1, MICALL2, MMP24, NKX2-5, NOTCH1, NOTCH3, NPPC, PLXNA1, PLXNA3, PLXNB1, PLXNB3, PTK2B, RAPH1, RIMS2, RMRP, RNF112, SCARF1, SCRT2, SEMA3B, SEMA4A, SEZ6, SH3TC2, SLIT1, SNAP25, SPHK1, SPTBN5, TSPO, ULK1, UNC13A, UNC5B, VEGFA, WNT2B, WNT7B]

[AGRN, APOE, ARHGEF1, ATP2B4, BMPR1B, BRSK2, CAMK1D, CELSR3, CHRNB2, CSF1R, DFNB31, DRAXIN, DRD2, DVL1, EGR2, EPHA3, GPC1, KIF26A, L1CAM, LIF, LRFN4, LRP1, LTK, MAP1B, MAPK8IP2, MAPK8IP3, MICALL2, #4 GO:0048666 neuron development 6.2E-6 2.9E-3 8.0E-15 89.0E-15 4.85 50.00 NOTCH1, NPPC, PLXNA1, PLXNA3, PLXNB1, PLXNB3, PTK2B, RAPH1, RIMS2, RMRP, SCARF1, SEMA3B, SEMA4A, SEZ6, SLIT1, SNAP25, SPHK1, SPTBN5, TSPO, ULK1, UNC13A, UNC5B, VEGFA] [AGRN, APOE, ARHGEF1, ATP2B4, BMPR1B, BRSK2, CAMK1D, CBLN1, CEBPB, CELSR3, CHD5, CHRNB2, CSF1R, DDIT4, DFNB31, DRAXIN, DRD2, DVL1, EGR2, EPHA2, EPHA3, FAIM2, FGF20, GPC1, IER2, JAG2, KIF26A, L1CAM, LIF, LRFN4, LRP1, LTK, MAP1B, MAPK8IP2, MAPK8IP3, MDGA1, MICALL2, NKX2- #4 GO:0048699 generation of neurons 800.0E-9 390.0E-6 8.0E-15 89.0E-15 4.61 66.00 5, NOTCH1, NOTCH3, NPPC, PLXNA1, PLXNA3, PLXNB1, PLXNB3, PTK2B, RAPH1, RIMS2, RMRP, RNF112, SCARF1, SCRT2, SEMA3B, SEMA4A, SEZ6, SLIT1, SNAP25, SPHK1, SPTBN5, TSPO, ULK1, UNC13A, UNC5B, VEGFA, WNT2B, WNT7B]

[APOE, ARHGEF1, CAMK1D, CHRNB2, DRAXIN, DVL1, EPHA3, L1CAM, LIF, LRP1, LTK, MAP1B, NKX2-5, NOTCH1, NOTCH3, PLXNA1, PLXNA3, regulation of neuron #4 GO:0045664 76.0E-6 34.0E-3 8.0E-15 89.0E-15 5.31 32.00 PLXNB1, PLXNB3, PTK2B, RIMS2, RMRP, differentiation RNF112, SCARF1, SEMA3B, SEMA4A, SEZ6, SLIT1, SNAP25, SPHK1, UNC13A, VEGFA]

[APOE, ARHGEF1, ATP2B4, BMPR1B, BRSK2, CELSR3, CHRNB2, CSF1R, DRAXIN, DRD2, DVL1, EGR2, GPC1, KIF26A, L1CAM, LRFN4, cell morphogenesis involved #4 GO:0048667 3.4E-6 1.6E-3 8.0E-15 89.0E-15 6.03 33.00 MAP1B, MAPK8IP2, MAPK8IP3, NOTCH1, NPPC, in neuron differentiation PLXNA1, PLXNA3, PLXNB1, PLXNB3, RAPH1, SEMA3B, SEMA4A, SLIT1, SPTBN5, ULK1, UNC5B, VEGFA] [APOE, ARHGEF1, BMPR1B, BRSK2, CELSR3, CHRNB2, CSF1R, DRAXIN, DRD2, DVL1, EGR2, GPC1, KIF26A, L1CAM, LRFN4, MAP1B, neuron projection #4 GO:0048812 4.9E-6 2.3E-3 8.0E-15 89.0E-15 5.78 34.00 MAPK8IP2, MAPK8IP3, NOTCH1, NPPC, morphogenesis PLXNA1, PLXNA3, PLXNB1, PLXNB3, RAPH1, RIMS2, SEMA3B, SEMA4A, SLIT1, SPTBN5, ULK1, UNC13A, UNC5B, VEGFA] [APOE, ARHGEF1, BMPR1B, BRSK2, CELSR3, CHRNB2, CSF1R, DRAXIN, DRD2, DVL1, EGR2, EPHA3, GPC1, KIF26A, L1CAM, LRFN4, MAP1B, #4 GO:0061564 axon development 76.0E-9 38.0E-6 8.0E-15 89.0E-15 6.92 34.00 MAPK8IP3, NOTCH1, NPPC, PLXNA1, PLXNA3, PLXNB1, PLXNB3, RAPH1, SCARF1, SEMA3B, SEMA4A, SLIT1, SPTBN5, TSPO, ULK1, UNC5B, VEGFA] [APOE, ARHGEF1, CAMK1D, CHRNB2, DRAXIN, DVL1, EPHA3, L1CAM, LIF, LRP1, LTK, MAP1B, regulation of neuron projection PLXNA1, PLXNA3, PLXNB1, PLXNB3, PTK2B, #4 GO:0010975 8.6E-6 4.1E-3 8.0E-15 89.0E-15 6.22 28.00 development RIMS2, RMRP, SCARF1, SEMA3B, SEMA4A, SEZ6, SLIT1, SNAP25, SPHK1, UNC13A, VEGFA]

[APOE, CAMK1D, DVL1, EPHA3, L1CAM, LIF, positive regulation of neuron LTK, MAP1B, PLXNB1, PLXNB3, PTK2B, RIMS2, #4 GO:0010976 84.0E-6 38.0E-3 8.0E-15 89.0E-15 6.98 18.00 projection development RMRP, SCARF1, SEZ6, SPHK1, UNC13A, VEGFA] [APOE, ARHGEF1, BMPR1B, BRSK2, CELSR3, CHRNB2, CSF1R, DRAXIN, DRD2, DVL1, EGR2, GPC1, KIF26A, L1CAM, LRFN4, MAP1B, #4 GO:0007409 axonogenesis 360.0E-9 180.0E-6 8.0E-15 89.0E-15 6.86 31.00 MAPK8IP3, NOTCH1, NPPC, PLXNA1, PLXNA3, PLXNB1, PLXNB3, RAPH1, SEMA3B, SEMA4A, SLIT1, SPTBN5, ULK1, UNC5B, VEGFA] [BMPR1B, CELSR3, CSF1R, DRAXIN, DVL1, EGR2, GPC1, KIF26A, L1CAM, MAPK8IP3, #4 GO:0007411 axon guidance 1.9E-6 940.0E-6 8.0E-15 89.0E-15 8.47 20.00 PLXNA1, PLXNA3, PLXNB1, PLXNB3, SEMA3B, SEMA4A, SLIT1, SPTBN5, UNC5B, VEGFA] [APOE, DRAXIN, DVL1, L1CAM, MAP1B, #4 GO:0048675 axon extension 3.0E-6 1.4E-3 8.0E-15 89.0E-15 11.11 14.00 PLXNA1, PLXNA3, PLXNB1, RAPH1, SEMA3B, SEMA4A, SLIT1, ULK1, VEGFA] [ABAT, ADAM8, ANGPT2, BBC3, CA9, CHRNB2, DDIT4, DRD2, ITGA2, KCNMA1, LOXL2, #5 GO:0001666 response to hypoxia 43.0E-6 19.0E-3 43.0E-6 86.0E-6 6.67 21.00 NOTCH1, NPPC, PDGFB, PRKCE, PTK2B, RYR2, SOCS3, VASN, VEGFA, WTIP] [ADAP1, AGAP6, AGRN, ALS2CL, ARHGAP40, ARHGDIG, ARHGEF1, ARHGEF4, C15orf62, CDC42EP1, CHRM4, EGFR, EPHA2, EPHA3, EPS8L1, FGF20, FGFR3, GRIN2B, HMHA1, IRS2, #6 GO:0043087 regulation of GTPase activity 100.0E-6 46.0E-3 100.0E-6 100.0E-6 4.95 35.00 OBSCN, PDGFB, PDGFRB, PLEKHG4, PLEKHG5, PLXNB1, PLXNB3, PTK2B, RAPGEF3, RGS16, RIN1, SBF1, SPTBN5, SYDE2, TNK2]

#7 GO:0043206 extracellular fibril organization 15.0E-6 7.2E-3 15.0E-6 46.0E-6 35.71 5.00 [LTBP2, LTBP3, MFAP4, MUC5AC, TNXB]

[ABAT, AHNAK, AMH, APOE, ARC, ATP2B4, BEST3, CACNA1H, CBARP, CHRNB2, DMPK, DRD2, DRD4, F2RL3, HCN2, HCN4, IRS2, #8 GO:0043269 regulation of ion transport 2.8E-6 1.3E-3 2.8E-6 11.0E-6 5.75 36.00 KCNC1, KCNC3, KCNH8, KCNJ14, KCNK15, KCNMA1, KCNQ2, MAPK8IP2, NKX2-5, NTSR1, PDGFB, PDGFRB, PRKCE, PTK2B, RAPGEF3, RYR2, SCN3A, SCN4A, TSPO] [AHNAK, ARC, ATP2B4, CACNA1H, CBARP, DRD2, DRD4, F2RL3, HCN2, HCN4, IRS2, regulation of ion KCNC1, KCNC3, KCNH8, KCNJ14, KCNK15, #8 GO:0034765 3.3E-6 1.6E-3 2.8E-6 11.0E-6 6.54 28.00 transmembrane transport KCNMA1, KCNQ2, MAPK8IP2, NTSR1, PDGFB, PDGFRB, PRKCE, PTK2B, RAPGEF3, RYR2, SCN3A, SCN4A] [ADGRL1, BAIAP3, CPLX1, CPLX2, DRD2, DRD4, DVL1, NRXN2, PPFIA4, RIMS2, RIMS4, SNAP25, #9 GO:0006836 neurotransmitter transport 13.0E-6 6.2E-3 4.8E-12 48.0E-12 8.37 17.00 SPHK1, SYN1, SYT12, SYT8, UNC13A]

[ABAT, ADGRL1, BAIAP3, BRSK2, CHGA, CPLX1, CPLX2, DRD2, DRD4, DVL1, FLNB, IRS2, LIF, LTBP4, MIDN, NR1D1, NRXN2, PIM3, PLXNA1, #9 GO:0023061 signal release 21.0E-9 10.0E-6 4.8E-12 48.0E-12 7.30 34.00 PPFIA4, PRKCE, PTGS1, RAB11FIP5, RAPGEF3, RIMS2, RIMS4, SMPD3, SNAP25, SPHK1, SYN1, SYT12, SYT8, UNC13A, VGF] [ABAT, APOE, ARC, ATP2B4, CHRNB2, CPLX2, DMPK, DRD2, DRD4, EGR2, IGSF9B, MAPK8IP2, modulation of synaptic #9 GO:0050804 2.4E-6 1.1E-3 4.8E-12 48.0E-12 7.34 24.00 NTSR1, PRKCE, PTK2B, RIMS2, RIMS4, RIN1, transmission SNAP25, SPHK1, SYN1, SYT12, UNC13A, VGF]

[ADGRL1, BAIAP3, CPLX1, CPLX2, DRD2, DRD4, presynaptic process involved DVL1, NRXN2, PPFIA4, RIMS2, RIMS4, SNAP25, #9 GO:0099531 600.0E-9 300.0E-6 4.8E-12 48.0E-12 10.49 17.00 in synaptic transmission SPHK1, SYN1, SYT12, SYT8, UNC13A]

[ABAT, ARC, CHRNB2, DRD2, DRD4, IGSF9B, positive regulation of synaptic #9 GO:0050806 5.2E-6 2.5E-3 4.8E-12 48.0E-12 10.61 14.00 NTSR1, PRKCE, PTK2B, RIMS2, SNAP25, transmission SPHK1, SYT12, UNC13A] [ABAT, CHRNB2, DMPK, DRD2, DRD4, IGSF9B, chemical synaptic #9 GO:0099565 710.0E-9 350.0E-6 4.8E-12 48.0E-12 13.54 13.00 MAPK8IP2, NTSR1, P2RY11, PTK2B, RIMS2, transmission, postsynaptic SEZ6, TSPO] [ABAT, ADGRL1, AGRN, APOE, ARC, ATP2B4, BAIAP3, BSN, CBLN1, CHRM4, CHRNB2, CPLX1, CPLX2, DMPK, DRD2, DRD4, DVL1, EGR2, EGR3, GRIN2B, IGSF9B, KCNQ2, LRFN4, #9 GO:0007268 synaptic transmission 780.0E-12 390.0E-9 4.8E-12 48.0E-12 6.84 45.00 MAPK8IP2, NPPC, NRXN2, NTSR1, P2RY11, PCDHB11, PPFIA4, PRKCE, PTK2B, PTPRS, RIMS2, RIMS4, RIN1, SEZ6, SNAP25, SPHK1, SYN1, SYT12, SYT8, TSPO, UNC13A, VGF] [ADGRL1, CACNA1H, CBARP, CPLX1, CPLX2, calcium ion regulated #9 GO:0017156 25.0E-6 11.0E-3 4.8E-12 48.0E-12 9.85 13.00 NOTCH1, RIMS2, RIMS4, SNAP25, SYN1, SYT12, exocytosis SYT8, UNC13A] inhibitory postsynaptic [ABAT, DRD4, IGSF9B, NTSR1, RIMS2] #9 GO:0060080 32.0E-6 14.0E-3 4.8E-12 48.0E-12 31.25 5.00 potential [ABAT, APOE, AVPR2, BEST3, CBARP, CHGA, DRD2, DRD4, FLNB, GRB10, IRS2, LIF, MAP1B, negative regulation of #10 GO:0051051 47.0E-6 21.0E-3 49.0E-12 390.0E-12 5.69 28.00 MIDN, NOTCH1, NTSR1, PIM3, PKD1, PLXNA1, transport PRKCE, PTGS1, PTK2B, RAB11FIP5, RHBDF1, SSC5D, SYT12, TRIM15, TRIP6] [ADGRL1, BAIAP3, CPLX1, CPLX2, DRD2, DRD4, DVL1, NRXN2, PPFIA4, RIMS2, RIMS4, SNAP25, #10 GO:0006836 neurotransmitter transport 13.0E-6 6.2E-3 49.0E-12 390.0E-12 8.37 17.00 SPHK1, SYN1, SYT12, SYT8, UNC13A] [ABAT, ADAM8, ADGRL1, AMH, ATP2B4, AVPR2, BAIAP3, BRSK2, CA9, CACNA1H, CBARP, CBLN1, CHGA, CHRNB2, CPLX1, CPLX2, CSF1R, DRD2, DRD4, DVL1, ECM1, FLNB, IRS2, KCNN4, LIF, LTBP2, LTBP3, LTBP4, MIDN, NLRP1, NOTCH1, NR1D1, NRXN2, NTSR1, #10 GO:0046903 secretion 17.0E-9 9.0E-6 49.0E-12 390.0E-12 5.25 62.00 PDGFB, PIM3, PLXNA1, PPFIA4, PRKCE, PTGS1, RAB11FIP5, RAPGEF3, RHBDF1, RIMS2, RIMS4, RLTPR, RMRP, SCG2, SLC17A9, SMPD3, SNAP25, SOCS1, SPHK1, SSC5D, SYN1, SYT12, SYT8, UNC13A, UNC13D, VEGFA, VGF, VWF]

[ABAT, ADAM8, ADGRL1, AMH, BAIAP3, BRSK2, CACNA1H, CBARP, CBLN1, CHGA, CHRNB2, CPLX1, CPLX2, CSF1R, DRD2, DRD4, DVL1, ECM1, FLNB, IRS2, KCNN4, LIF, LTBP2, LTBP3, LTBP4, MIDN, NLRP1, NOTCH1, NR1D1, NRXN2, #10 GO:0032940 secretion by cell 6.5E-9 3.3E-6 49.0E-12 390.0E-12 5.58 58.00 NTSR1, PDGFB, PIM3, PLXNA1, PPFIA4, PRKCE, PTGS1, RAB11FIP5, RAPGEF3, RHBDF1, RIMS2, RIMS4, RLTPR, SCG2, SLC17A9, SMPD3, SNAP25, SOCS1, SPHK1, SSC5D, SYN1, SYT12, SYT8, UNC13A, UNC13D, VEGFA, VGF, VWF]

[ABAT, ADAM8, AMH, AVPR2, BRSK2, CACNA1H, CBARP, CHGA, CHRNB2, CPLX1, CPLX2, CSF1R, DRD2, DRD4, FLNB, IRS2, KCNN4, LIF, MIDN, NLRP1, NOTCH1, NR1D1, #10 GO:0051046 regulation of secretion 360.0E-9 180.0E-6 49.0E-12 390.0E-12 5.76 43.00 NTSR1, PIM3, PLXNA1, PRKCE, PTGS1, RAB11FIP5, RAPGEF3, RHBDF1, RIMS2, RIMS4, RLTPR, SMPD3, SNAP25, SOCS1, SPHK1, SSC5D, SYN1, SYT12, SYT8, UNC13A, UNC13D]

[ABAT, AVPR2, CBARP, CHGA, DRD2, DRD4, negative regulation of #10 GO:0051048 31.0E-6 14.0E-3 49.0E-12 390.0E-12 7.83 17.00 FLNB, LIF, MIDN, NOTCH1, PIM3, PLXNA1, secretion PTGS1, RAB11FIP5, RHBDF1, SSC5D, SYT12] [ABAT, ADAM8, AMH, BRSK2, CBLN1, CPLX1, CSF1R, DRD2, DRD4, IRS2, KCNN4, LTBP2, LTBP3, MIDN, NLRP1, NOTCH1, NR1D1, PIM3, #10 GO:0009306 protein secretion 14.0E-6 6.8E-3 49.0E-12 390.0E-12 5.88 30.00 PLXNA1, PRKCE, RAB11FIP5, RAPGEF3, RHBDF1, RIMS2, RLTPR, SCG2, SNAP25, SOCS1, SSC5D, VGF] [ABAT, BCL3, BRSK2, CPLX1, DRD2, EDAR, FLNB, IRS2, LIF, LTBP4, MIDN, NR1D1, PIM3, #10 GO:0015833 peptide transport 12.0E-6 5.8E-3 49.0E-12 390.0E-12 6.85 23.00 PLXNA1, PRKCE, RAB11FIP5, RAPGEF3, RIMS2, SMPD3, SNAP25, SPHK1, TRIP6, VGF] [ABAT, ADGRL1, BAIAP3, BRSK2, CHGA, CPLX1, CPLX2, DRD2, DRD4, DVL1, FLNB, IRS2, LIF, LTBP4, MIDN, NR1D1, NRXN2, PIM3, PLXNA1, #10 GO:0023061 signal release 21.0E-9 10.0E-6 49.0E-12 390.0E-12 7.30 34.00 PPFIA4, PRKCE, PTGS1, RAB11FIP5, RAPGEF3, RIMS2, RIMS4, SMPD3, SNAP25, SPHK1, SYN1, SYT12, SYT8, UNC13A, VGF] [ABAT, CBARP, CHGA, DRD2, DRD4, LIF, MIDN, negative regulation of #10 GO:1903531 99.0E-6 44.0E-3 49.0E-12 390.0E-12 7.77 15.00 NOTCH1, PIM3, PLXNA1, PTGS1, RAB11FIP5, secretion by cell RHBDF1, SSC5D, SYT12] [ADGRL1, BAIAP3, CPLX1, CPLX2, DRD2, DRD4, presynaptic process involved DVL1, NRXN2, PPFIA4, RIMS2, RIMS4, SNAP25, #10 GO:0099531 600.0E-9 300.0E-6 49.0E-12 390.0E-12 10.49 17.00 in synaptic transmission SPHK1, SYN1, SYT12, SYT8, UNC13A]

[ABAT, BRSK2, CHGA, CPLX1, DRD2, FLNB, IRS2, LIF, LTBP4, MIDN, NR1D1, PIM3, PLXNA1, #10 GO:0046879 hormone secretion 91.0E-6 41.0E-3 49.0E-12 390.0E-12 6.33 21.00 PRKCE, PTGS1, RAB11FIP5, RAPGEF3, RIMS2, SMPD3, SNAP25, VGF] [ABAT, ADGRL1, AGRN, APOE, ARC, ATP2B4, BAIAP3, BSN, CBLN1, CHRM4, CHRNB2, CPLX1, CPLX2, DMPK, DRD2, DRD4, DVL1, EGR2, EGR3, GRIN2B, IGSF9B, KCNQ2, LRFN4, #10 GO:0007268 synaptic transmission 780.0E-12 390.0E-9 49.0E-12 390.0E-12 6.84 45.00 MAPK8IP2, NPPC, NRXN2, NTSR1, P2RY11, PCDHB11, PPFIA4, PRKCE, PTK2B, PTPRS, RIMS2, RIMS4, RIN1, SEZ6, SNAP25, SPHK1, SYN1, SYT12, SYT8, TSPO, UNC13A, VGF]

[ABAT, BRSK2, CPLX1, DRD2, FLNB, IRS2, LIF, LTBP4, MIDN, NR1D1, PIM3, PLXNA1, PRKCE, #10 GO:0030072 peptide hormone secretion 41.0E-6 19.0E-3 49.0E-12 390.0E-12 7.12 19.00 RAB11FIP5, RAPGEF3, RIMS2, SMPD3, SNAP25, VGF] [ABAT, ADAM8, ADAMTS13, ADAP1, ADGRL1, ADORA2A, AMH, ANGPT2, APOE, ARC, ATP6V1C2, BMPR1B, BOK, C10orf54, CEBPA, CELSR3, CHAC1, CHRM4, CHRNB2, COL16A1, CSF1R, DDIT4, DMPK, DRAXIN, DRD2, DRD4, DVL1, ECM1, EDAR, EGFR, EPHA2, EPHA3, FGF20, FGF21, FGFR3, FSTL3, GDF15, GLIS2, GPC1, GRB10, GRIN2B, GRIP2, HIC1, HLA-G, IFITM1, IGFBP1, IGFBP3, IGSF9B, IL10RA, IL9R, INHBE, IRF7, IRS2, ITGA2, ITGA5, JAG2, KCNN4, KREMEN2, LAMA5, LGR6, LIF, LIME1, LRP1, cell surface receptor signaling #11 GO:0007166 35.0E-9 17.0E-6 35.0E-9 210.0E-9 4.07 113.00 LTBP2, LTBP3, LTBP4, LTK, MAPK8IP2, MMRN2, pathway MUC20, NKX2-5, NOTCH1, NOTCH3, NPPC, NTSR1, P2RY11, PDGFB, PDGFRB, PLXNA1, PLXNA3, PLXNB1, PLXNB3, PRKCE, PTK2B, PTP4A3, RHBDF1, RIMS2, RLTPR, RYR2, SCG2, SCRT2, SEMA3B, SEMA4A, SEZ6, SH2B2, SH3TC2, SLIT1, SOCS1, SOCS3, SPHK1, TCIRG1, TGM2, TMEM88, TNFRSF25, TNFRSF6B, TNK2, TSPO, UNC5B, VASN, VEGFA, WNT2B, WNT7B, ZC3H3]

[ANGPT2, ATP6V1C2, BMPR1B, C10orf54, CSF1R, DDIT4, EGFR, EPHA2, EPHA3, FGF20, FGF21, FGFR3, FSTL3, GDF15, GPC1, GRB10, GRIN2B, IGFBP1, IGFBP3, INHBE, IRS2, ITGA5, enzyme linked receptor #11 GO:0007167 8.0E-6 3.8E-3 35.0E-9 210.0E-9 4.88 49.00 LIF, LRP1, LTBP2, LTBP3, LTBP4, LTK, MMRN2, protein signaling pathway MUC20, NKX2-5, NOTCH1, NPPC, PDGFB, PDGFRB, PLXNA1, PTK2B, PTP4A3, RHBDF1, RYR2, SH2B2, SH3TC2, SOCS1, SOCS3, TCIRG1, TNK2, VASN, VEGFA, ZC3H3]