RFP No.: 744-R1426-Plastinated Specimens

EXHIBIT ONE

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PLASTINATED BRAIN SPECIMENS

As illustrated or similar

Required: 12 copies of the 7 different brain specimens illustrated

05/20/2014 Page 2 BRAIN SPECIMEN NO. 1 –Whole Brain Shows all cranial nerves and major arteries.

05/20/2014 Page 3 BRAIN SPECIMEN NO. 2 – Sagittal Section To show features illustrated. The medulla should be intact and not cut as shown.

05/20/2014 Page 4 BRAIN SPECIMEN NO. 3 –LIMBIC SYSTEM, Medial View Fornix dissected and pathway to temporal lobe opened, caudate nucleus exposed. The arachnoid should be left intact in the areas that are not dissected. A tunnel dissected to follow fornix to temporal lobe

05/20/2014 Page 5 BRAIN SPECIMEN NO. 3 –LIMBIC SYSTEM, Lateral View Temporal lobe dissected to show fornix joining hippocampus, amygdala exposed

05/20/2014 Page 6 BRAIN SPECIMEN NO. 4 –TEMPORAL LOBE AND INSULA REMOVED Internal capsule and corona radiata, optic radiations exposed. Entire lentiform nucleus should be removed, not half as shown. Cerbellum dissected to show superior and inferior cerebellar peduncles as well as cerebral peduncle.

05/20/2014 Page 7 BRAIN SPECIMEN NO.5 – CORONAL SECTION THROUGH LENTIFORM NUCLEUS Hippocampus, caudate and fornix shown

05/20/2014 Page 8 BRAIN SPECIMEN NO.6 –SECTION ANTERIOR TO PREVIOUS SECTION (5) Amygdala and anterior commissure exposed. Choroid plexus preserved.

CHOROID PLEXUS

05/20/2014 Page 9 BRAIN SPECIMEN NO. 7 –SECTION THROUGH THALAMUS, MESENCEPHALON AND PONS

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DISSECTED HEAD AND NECK SPECIMENS

Required: 4 copies of each of the half or whole head and neck specimens

Specimens should be impregnated with silicon polymer. They should retain some flexibility and not be brittle and easily damaged.

05/20/2014 Page 11 HALF HEAD AND NECK SPECIMEN NO. 1 • This is a sagittal cut represented by combining the 3 Figures below. • This specimen is cut from the crown of the head (Fig. 1)down through the base of the neck (Fig. 2) • Nasal septum is intact but demonstrates CN 1 branches and the nasopalatine nerve (Fig. 3) • Falx cerebri is intact, brain bisected (Fig. 1) • Larynx is bisected (Fig. 2)

Fig. 1 Fig. 2

Fig. 3

05/20/2014 Page 12 HALF HEAD AND NECK SPECIMEN NO. 1 Lateral view: Face (Fig. 1, 2) and Superficial Neck (Fig. 3) • Face dissected (Fig. 1), roof of cranium in place (Fig. 2) to accommodate brain and falx cerebri in medial view. Full neck attached as in Fig. 3 below. Fig. 1 FACE AND CN VII • Some parotid and duct remain • Muscles of face, buccinator dissected • Facial artery and its branches • Cranial roof should be in place to complete view from medial side with brain and falx cerebri.

Fig. 2

05/20/2014 Page 13 HALF HEAD AND NECK SPECIMEN NO. 1 Lateral view: Face (Fig. 1, 2) and Superficial Neck (Fig. 3)

Fig. 3 SUPERFICIAL DISSECTION OF THE NECK • In addition to the face dissection • Lower face exposed with parotid and facial artery and vein. • Submandibular gland in place and suprahyoid mucles exposed around it. • Cervical plexus nerves and external jugular exposed • Infrahyoid muscles partly exposed

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05/20/2014 Page 14 HALF HEAD AND NECK SPECIMEN NO. 2 Medial view: intact nasal wallII. (Fig. Conchae 1), oropharynx (Fig.and 1 & Meatuses2), floor of mouth (Fig. 3) • Fig. 1 and 2: Intact surface of lateral nasal wall and oropharynx

Fig. 1

05/20/2014 Page 15 HALF HEAD AND NECK SPECIMEN NO. 2 Medial view: intact nasal wall (Fig. 1), oropharynx (Fig. 1 & 2), floor of mouth (Fig. 3)

Fig. 2

05/20/2014 Page 16 HALF HEAD AND NECK SPECIMEN NO. 2 Medial view: intact nasal wall (Fig. 1), oropharynx (Fig. 1,2), floor of mouth (Fig. 3) • Floor of mouth with intact mucosa: tongue pulled medially (not as illustrated) in order to expose sublingual sulcus, sublingual plica, sublingual caruncle, palatoglossal arch, palatopharyngeal arch.

Fig. 3

05/20/2014 Page 17 HALF HEAD AND NECK SPECIMEN NO. 2 Lateral view: Superficial muscles of mastication (Fig. 1) and intermediate depth of neck (Fig. 2) Fig. 1 Temporalis and both heads of masseter exposed. Muscles of face may be dissected and vessels to face may be shown here instead of on Specimen 1.

Fig. 1

05/20/2014 Page 18 HALF HEAD AND NECK SPECIMEN NO. 2 Lateral view: Superficial muscles of mastication (Fig. 1) and intermediate depth of neck (Fig. 2)

• The ansa cervicalis is exposed. • Submandibular gland removed but facial artery and vein preserved Fig. 2 • Supra and infrahyoid muscles displayed. • Internal jugular and branches. • In posterior triangle CN XI

05/20/2014 Page 19 HALF HEAD AND NECK SPECIMEN NO. 3 Medial view: dissected nasal cavity (Fig. 1), nasopharynx and oropharynx (Fig. 2) • Conchae have been reflected and meatuses opened to reveal their content. Sphenoid sinus and its drainage revealed. Pharyngeal mucosa will be removed as in Fig. 2

Fig. 1 Ethmoidal bulla

Semilunar hiatus

05/20/2014 Page 20 HALF HEAD AND NECK SPECIMEN NO. 3 Medial view: dissected nasal cavity (Fig.1), nasopharynx and oropharynx (Fig. 2)

• Mucosa has been removed from nasopharynx and oropharynx to reveal musculature. These features are posterior to those in Fig. 1 where the mucosa is intact.

Fig. 2

05/20/2014 Page 21 HALF HEAD AND NECK SPECIMEN NO. 3 Lateral view: muscles of mastication (Fig. 1), temporomandibular ligament (Fig. 2), cranial floor (Fig. 3), anterior dissection of (Fig. 4). deep neck (Fig. 5)

• Masseter removed perhaps showing its neurovascular supply. • Temporal tendon removed from temporalis • Buccinator revealed, perhaps other muscles of face and vessels

Fig. 1

05/20/2014 Page 22 HALF HEAD AND NECK SPECIMEN NO. 3 Lateral view: muscles of mastication (Fig. 1), temporomandibular ligament (Fig. 2), cranial floor (Fig. 3), anterior dissection of orbit (Fig. 4), deep neck (Fig. 5)

• Temporomandibular (lateral) ligament • here the muscles of mastication have been removed, but we want them as in Fig. 1

Fig. 2

05/20/2014 Page 23 HALF HEAD AND NECK SPECIMEN NO. 3 Lateral view: muscles of mastication (Fig. 1), temporomandibular ligament (Fig. 2), cranial floor (Fig. 3), anterior dissection of orbit (Fig. 4), deep neck (Fig. 5)

• Cranial floor with dura • This will be only on one half of the sagittaly Fig. 3 split specimen • All cranial nerves displayed • All arteries welcome • Trigeminal ganglion and 3 divisions of V revealed. • Dural sinuses opened

05/20/2014 Page 24 HALF HEAD AND NECK SPECIMEN NO. 3 Lateral view: muscles of mastication (Fig. 1), temporomandibular ligament (Fig. 2), cranial floor (Fig. 3), anterior dissection of orbit (Fig. 4), deep neck (Fig. 5) • lacrimal gland, inferior oblique, inferior rectus, superior oblique and trochlea, supraorbital and infraorbital nerves revealed. • Perhaps lacrimal sac, superior, medial and lateral rectus muscles

Fig. 4

05/20/2014 Page 25 HALF HEAD AND NECK SPECIMEN NO. 3 Lateral view: muscles of mastication (Fig. 1), temporomandibular ligament (Fig. 2), cranial floor (Fig. 3), anterior dissection of orbit (Fig. 4), deep neck (Fig. 5)

• Deep neck • Internal jugular and branches have been removed • Carotids and their branches exposed • XII demonstrated • Vagus and sympathetic trunk exposed • Thyrocervical trunk and branches exposed • Scalene muscles cleaned and brachial plexus exposed • Subclavian artery and vein exposed • Internal and external laryngeal nerves exposed • If possible: recurrent laryngeal nerve

Fig. 5

05/20/2014 Page 26 HALF HEAD AND NECK SPECIMEN NO. 4 Medial view: floor of the mouth (Fig. 1), (Fig. 2) • Tongue has been reflected medialy and mucosa removed. Revealed: genioglossus, hyoglossus, sublingual gland, lingual and hypoglossal nerves, submandibular duct,

Fig. 1

05/20/2014 Page 27 HALF HEAD AND NECK SPECIMEN NO. 4 Medial view: floor of the mouth (Fig. 1), pterygopalatine fossa (Fig. 2) • Pterygopalatine fossa. Revealing , greater and lesser , descending palatine artery (not shown), , pterygopalatine nerves, nerve of the pterygoid canal, perhaps nerve of the pharyngeal cana • Greater and lesser palatine nerves distributed to the palate • Perhaps olfactory and anterior ethmoidal nerves • Nerve of the incisive canal

Fig. 2

05/20/2014 Page 28 HALF HEAD AND NECK SPECIMEN NO. 4 Lateral view: deep muscles of mastication (Fig. 1), superior view of orbit (Fig. 2)

• Both heads of medial and lateral pterygoid muscles • Temporomandibular joint is cut sagittally revealing attachment of superior head of lateral pterygoid to articular disk and pterygoid fovea.

Fig. 1

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05/20/2014 Page 29 HALF HEAD AND NECK SPECIMEN NO. 4 Lateral view: deep muscles of mastication (Fig. 1), superior view of orbit (Fig. 2)

• Superior view of left orbit emphasizing features not seen in Whole Head Specimen no 1 that follows. • Lateral rectus with abducens nerve • and gland • Superior oblique with trochlear nerve and trochlea • Optic nerve • • Perhaps • Oculomotor nerve

Fig. 2

05/20/2014 Page 30 HALF HEAD AND NECK SPECIMEN NO. 5 Medial view: floor of the mouth (Fig. 1), (Fig. 2)

• Tongue, medial pterygoid and pharyngeal wall removed revealing lateral floor of the mouth and part of infratemporal fossa. • traced back to junction with chorda tympani • Sublingual and submandibular glands • Submandibular duct with lingual nerve crossing inferior to it • Hypoglossal nerve • Mylohyoid, geniohyoid muscles and remains of genioglossus, styloglossus, medial pterygoid, hyoglossus muscles. • Sphenomandibular ligament

Fig. 1

05/20/2014 Page 31 HALF HEAD AND NECK SPECIMEN NO. 5 Medial view: floor of the mouth (Fig. 1), maxillary sinus (Fig. 2) • Maxillary sinus opened from the medial side. (student dissection) • To show features labled and artery Reflected nasal septum (optional) Posterior superior Fig. 2 alveolar nerve

Greater and lesser palatine nerves

Maxillary sinus

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05/20/2014 Page 32 HALF HEAD AND NECK SPECIMEN NO. 5 Lateral view: lateral view of dura in cranial cavity (Fig. 1), lateral dissection of pharynx (Fig. 2) • Lateral wall of cranium removed to reveal dura on brain with middle meningeal artery

Fig. 1

05/20/2014 Page 33 HALF HEAD AND NECK SPECIMEN NO. 5 Lateral view: lateral view of dura in cranial cavity (Fig. 1), lateral dissection of pharynx (Fig. 2) • To show features labeled

Fig. 2

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05/20/2014 Page 34 WHOLE HEAD SPECIMEN NO. 1 Infratemporal fossa (Fig. 1 and 2), dural folds (Fig. 2), posterior dissection of pharynx (Fig. 3)

• Infratemporal fossa emphases on vessels and nerves, communications with orbit, and face • Maxillary artery and branches • and branches • Superior and inferior alveolar nerves • Hypoglossal nerve and superior root of ansa

Fig. 1

05/20/2014 Page 35 WHOLE HEAD SPECIMEN NO. 1 Infratemporal fossa (Fig. 1 and 2), dural folds (Fig. 2), posterior dissection of pharynx (Fig. 3)

• Side opposite to that of Fig. 1: trigeminal ganglion and distribution of 3 divisions • Superolateral orbit dissected • Infraorbital nerve branches on face • Maxillary nerve including superior alveolar nerves • Mandibular division and branches to mouth, , cheek • with branch to TMJ and parotid, showing loop that surrounds middle meningeal artery. • Dural folds

Fig. 2

05/20/2014 Page 36 WHOLE HEAD SPECIMEN NO. 1 Infratemporal fossa (Fig. 1 and 2), dural folds (Fig. 2), posterior dissection of pharynx (Fig. 3)

• Posterior dissection of pharynx. • 3 constrictor muscles • Sympathetic trunk and ganglia • Vagus and superior laryngeal nerve • Carotid arteries and internal jugular • Stylopharyngeus muscle and glossopharyngeal nerve • Spinal accessory nerve • Hypoglossal nerve • Stylohyoid and posterior belly of digastric.

Fig. 3. 5

05/20/2014 Page 37 WHOLE HEAD OR HALF HEAD SPECIMEN LATERAL VIEW: lateral dissection of oral region • This dissection is not paired up with any other view of the head‐neck, but could be done in combination or could be stand‐alone. • Half of mandible has been removed as well as buccinator, muscles of mastication • Reveals floor of mouth from lateral approach • Prefer hyoglossus to remain in place with lingual nerve and hypoglossal nerve on its lateral surface • Lingual nerve passing under submandibular duck and submandibular ganglion • Stylopharyngeus with glossopharyngeal nerve • Genioglossus and geniohyoid muscles

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SECTIONS OF HEAD

13 horizontal, 3 frontal, 1 sagittal.

4 sets of each required.

HORIZONTAL SECTIONS OF HEADS AND NECKS IMPREGNATED WITH CURED POLYMER

13 horizontal slices evenly spaced from the levels of the pituitary down to the vocal cords. These sections should clearly show distinct anatomical features at each level of section.

05/20/2014 Page 39 FRONTAL SECTIONS OF HEAD IMPREGNATED WITH CURED POLYMER (OR SILICONE IN THICK SECTIONS)

Level 1: At the level of the temporomandibular joint. Should show spine of sphenoid.

05/20/2014 Page 40 FRONTAL SECTIONS OF HEAD IMPREGNATED WITH CURED POLYMER (OR SILICONE IN THICK SECTIONS) Level 2: At the level of the infratemporal fossa (viewer's right side of section)

05/20/2014 Page 41 FRONTAL SECTIONS OF HEAD IMPREGNATED WITH CURED POLYMER (OR SILICONE IN THICK SECTIONS) Level 3: At the level of the second molars as illustrated

05/20/2014 Page 42 THICK SAGITTAL SECTION SHOWING MEDIAL AND LATERAL FEATURES Prefer impregnation with silicone polymer.

Medial side: Through the temporomandibular joint as illustrated, showing labeled structures. See next picture for lateral side.

05/20/2014 Page 43 THICK SAGITTAL SECTION Lateral side: showing medial and lateral pterygoid muscles.

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