DYNAMICS OF SUCCESS Desitin Company Profile Our Heritage: Medium-sized, Specialized Pharmaceutical Company

. Founded 100 years ago in Hamburg . Independent, family-owned, profitable company, based in Hamburg . About 300 employees in development, production, sales, medicine, marketing and administration . Established as a specialist in the fields of and Parkinson’s disease . Addition of further CNS indications . General managers Philipp Bloching MD, Martin Schütt and Christoph Steinschulte PhD

2 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Headquarters and Place of Production

Desitin Arzneimittel GmbH Weg beim Jaeger 214 22335 Hamburg Germany

Phone: +49 40 59101-0 Email: [email protected]

3 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Strategy

Concentration on special Rx products in European countries with successful partnerships, licensing agreements and own R&D

4 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Expertise: CNS Indications

. In-depth knowledge in epilepsy and Parkinson's disease . High medical expertise knowledge in dystonia, psychiatry, addiction, sleeping disorders . Success stories in scientific marketing of own and in-licensed Rx-products . Close networking with key opinion leaders . Relationships to patient organizations in several indications

5 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Expertise: Pan-European Distribution Network

. Product and target-group specific sales strategies . Subsidiaries with sales teams in 11 European countries . Distribution partners in further 15 European countries

6 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Commercial Structure

DESITIN - A EUROPEAN CNS FORCE

KEY COUNTRIES (WITH OWN AFFILIATES) Germany, Norway, Denmark, Sweden, Switzerland, Czech Republic, Slovakia, Romania, U. K., Estonia, Moldova

PARTNER COUNTRIES (WITH LOCAL DISTRIBUTORS) Austria, Belgium, Croatia, Finland, France, Hungary, Iceland, Netherlands, Portugal, Spain, Turkey

7 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Current Main Partner in Pan-EU Network

France Spain Portugal Netherlands Belgium Finland Austria Croatia Hungary Iceland

8 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Expertise: Fully-Integrated Pharmaceutical Company

. Long experience in development of products with different application forms . In-house production of pharmaceutical products . Strong regulatory know-how for European markets

9 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Driving Growth by Own Developments

1982 1996 2006 2011 2019 Rectal tubes First ready-to-use First snab-tab First coated mini tablets First Sultiame suspension ( DESITIN® for optimal up-titration of (Ospolot® Suspension) rectal tubes) injection solution (Lamotrigine DESITIN® quadro) (Levetiracetam DESITIN®) (Orfiril® injection solution)

1984 1998/1999 2008 2016 2019 First sustained- First sustained-release First modified-release First parkinson First release mini tablets Valproate combination therapy suspension (Orfiril® long) (Apydan® extent) in one tablet blister (Zonisol® Suspension) (Timonil® retard) (PramiDopa®)

10 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Driving Growth with Marketing Licences

1993 1998 2007 2010 2012 2016 Lamotrigine Beta-Interferon 1a Piribedil (CLARIUM®) Naltrexone 5-Aminolevulinic acid Riluzole liquid ® ® (Lamictal ) (Rebif ) (DE) (Adepend®) (Ameluz®) (Teglutik®) Botulinum Toxin A (DE) (DE) (DE) (DK, NO, SE) (DE) (Xeomin®) (DK, NO, CZ, RO, SK)

1995 2001 2007 2008 2011 2017 DEC Paroxetinemesylate Naltrexone Tetrabenazine Apomorphine (Almirid®) (Euplix®) (DE) (Naltrexon HCI aop) (Diacomit®) (Tetmodis®) (Apomorphine Archimedes) (DE) Oxcarbazepine (DE) (DE, DK, FI, NO, SE, (DE) (Timox®) (DE) CZ, RO, SK) (DE)

11 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Performance at a Glance

Total Turnover in millions of EUR (Business Year: Oct 1st to Sept 30th)

140

120 INTERNATIONAL 100 € 80

million GERMANY 60

40

20

0 07/08 09/10 11/12 13/14 15/16 17/18 19/20

12 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Share of Sales by Regions

Fiscal Year 2019/20 Total Turnover: 118.5 million € 57%

14% GERMANY NORTHERN EUROPE WESTERN EUROPE EASTERN EUROPE ROW

4% 13% 12%

13 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Share of Sales by Therapeutic Areas

Fiscal Year 2019/20 Total Turnover: 118.5 million € 65%

CNS Products: > 90 %

EPILEPSY = 65% MOVEMENT DISORDERS = 25% 25% OTHER INDICATIONS = 10% 2% 3% 5%

14 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Production Output

76%

1 Billion 24%

semi-finished goods FINISHED GOODS IN HOUSE PRODUCTIONS SUBCONTRACTED

15 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Passion for Partnerships in Europe

Neurology, e. g.: New / Strategic Indications, e. g.:

MOVEMENT NEPHRO- DERMA- EPILEPSY UROLOGY DISORDERS LOGY TOLOGY

New Therapeutic Entities, Pediatric Drugs, Orphans

Late Stage Projects (> Ph IIb) - - - New Application Forms: DE - - - OTX Products: RO, CZ + SK - - -

16 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Development Pipeline

CANDIDATE INDICATION PHASE I/PK PHASE II PHASE III MAA MARKET

DST-071 Epilepsy Complete Ongoing 2022 oral liquid

DST-096 Obstructive Complete Ongoing 2027 oral solid Sleep Apnea

DST-100 Parkinson‘s Complete Ongoing 2020 medical device Disease

DST-111 MRSA Ongoing 2028 liquid Eradication

DST-112 Epilepsy Ongoing 2023 parenteral

DST-115 Epilepsy Ongoing 2022 oral solid

DST-119 Epilepsy Complete Ongoing buccal 2021

DST-120 Epilepsy Ongoing 2023 parenteral DST-123 Epilepsy Ongoing 2023 oral solid

17 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Strong Commitment in Partnering

. Policy of open books: complete transparency in activities and figures . Passion for close co-operations . High flexibility of a privately held independent company . Fast decision-making procedures . Share of knowledge and experience

18 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 DYNAMICS OF SUCCESS Desitin Company Profile