DYNAMICS OF SUCCESS Desitin Company Profile Our Heritage: Medium-sized, Specialized Pharmaceutical Company
. Founded 100 years ago in Hamburg . Independent, family-owned, profitable company, based in Hamburg . About 300 employees in development, production, sales, medicine, marketing and administration . Established as a specialist in the fields of epilepsy and Parkinson’s disease . Addition of further CNS indications . General managers Philipp Bloching MD, Martin Schütt and Christoph Steinschulte PhD
2 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Headquarters and Place of Production
Desitin Arzneimittel GmbH Weg beim Jaeger 214 22335 Hamburg Germany
Phone: +49 40 59101-0 Email: [email protected]
3 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Strategy
Concentration on special Rx products in European countries with successful partnerships, licensing agreements and own R&D
4 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Expertise: CNS Indications
. In-depth knowledge in epilepsy and Parkinson's disease . High medical expertise knowledge in dystonia, psychiatry, addiction, sleeping disorders . Success stories in scientific marketing of own and in-licensed Rx-products . Close networking with key opinion leaders . Relationships to patient organizations in several indications
5 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Expertise: Pan-European Distribution Network
. Product and target-group specific sales strategies . Subsidiaries with sales teams in 11 European countries . Distribution partners in further 15 European countries
6 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Commercial Structure
DESITIN - A EUROPEAN CNS FORCE
KEY COUNTRIES (WITH OWN AFFILIATES) Germany, Norway, Denmark, Sweden, Switzerland, Czech Republic, Slovakia, Romania, U. K., Estonia, Moldova
PARTNER COUNTRIES (WITH LOCAL DISTRIBUTORS) Austria, Belgium, Croatia, Finland, France, Hungary, Iceland, Netherlands, Portugal, Spain, Turkey
7 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Current Main Partner in Pan-EU Network
France Spain Portugal Netherlands Belgium Finland Austria Croatia Hungary Iceland
8 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Expertise: Fully-Integrated Pharmaceutical Company
. Long experience in development of products with different application forms . In-house production of pharmaceutical products . Strong regulatory know-how for European markets
9 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Driving Growth by Own Developments
1982 1996 2006 2011 2019 Rectal tubes First ready-to-use First snab-tab Lamotrigine First coated mini tablets First Sultiame suspension (Diazepam DESITIN® Valproate for optimal up-titration of Levetiracetam (Ospolot® Suspension) rectal tubes) injection solution (Lamotrigine DESITIN® quadro) (Levetiracetam DESITIN®) (Orfiril® injection solution)
1984 1998/1999 2008 2016 2019 First sustained- First sustained-release First modified-release First parkinson First Zonisamide release mini tablets Valproate Oxcarbazepine combination therapy suspension Carbamazepine (Orfiril® long) (Apydan® extent) in one tablet blister (Zonisol® Suspension) (Timonil® retard) (PramiDopa®)
10 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Driving Growth with Marketing Licences
1993 1998 2007 2010 2012 2016 Lamotrigine Beta-Interferon 1a Piribedil (CLARIUM®) Naltrexone 5-Aminolevulinic acid Riluzole liquid ® ® (Lamictal ) (Rebif ) (DE) (Adepend®) (Ameluz®) (Teglutik®) Botulinum Toxin A (DE) (DE) (DE) (DK, NO, SE) (DE) (Xeomin®) (DK, NO, CZ, RO, SK)
1995 2001 2007 2008 2011 2017 DEC Paroxetinemesylate Naltrexone Stiripentol Tetrabenazine Apomorphine (Almirid®) (Euplix®) (DE) (Naltrexon HCI aop) (Diacomit®) (Tetmodis®) (Apomorphine Archimedes) (DE) Oxcarbazepine (DE) (DE, DK, FI, NO, SE, (DE) (Timox®) (DE) CZ, RO, SK) (DE)
11 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Performance at a Glance
Total Turnover in millions of EUR (Business Year: Oct 1st to Sept 30th)
140
120 INTERNATIONAL 100 € 80
million GERMANY 60
40
20
0 07/08 09/10 11/12 13/14 15/16 17/18 19/20
12 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Share of Sales by Regions
Fiscal Year 2019/20 Total Turnover: 118.5 million € 57%
14% GERMANY NORTHERN EUROPE WESTERN EUROPE EASTERN EUROPE ROW
4% 13% 12%
13 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Share of Sales by Therapeutic Areas
Fiscal Year 2019/20 Total Turnover: 118.5 million € 65%
CNS Products: > 90 %
EPILEPSY = 65% MOVEMENT DISORDERS = 25% 25% OTHER INDICATIONS = 10% 2% 3% 5%
14 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Production Output
76%
1 Billion 24%
semi-finished goods FINISHED GOODS IN HOUSE PRODUCTIONS SUBCONTRACTED
15 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Passion for Partnerships in Europe
Neurology, e. g.: New / Strategic Indications, e. g.:
MOVEMENT NEPHRO- DERMA- EPILEPSY UROLOGY DISORDERS LOGY TOLOGY
New Therapeutic Entities, Pediatric Drugs, Orphans
Late Stage Projects (> Ph IIb) - - - New Application Forms: DE - - - OTX Products: RO, CZ + SK - - -
16 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Development Pipeline
CANDIDATE INDICATION PHASE I/PK PHASE II PHASE III MAA MARKET
DST-071 Epilepsy Complete Ongoing 2022 oral liquid
DST-096 Obstructive Complete Ongoing 2027 oral solid Sleep Apnea
DST-100 Parkinson‘s Complete Ongoing 2020 medical device Disease
DST-111 MRSA Ongoing 2028 liquid Eradication
DST-112 Epilepsy Ongoing 2023 parenteral
DST-115 Epilepsy Ongoing 2022 oral solid
DST-119 Epilepsy Complete Ongoing buccal 2021
DST-120 Epilepsy Ongoing 2023 parenteral DST-123 Epilepsy Ongoing 2023 oral solid
17 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 Our Strong Commitment in Partnering
. Policy of open books: complete transparency in activities and figures . Passion for close co-operations . High flexibility of a privately held independent company . Fast decision-making procedures . Share of knowledge and experience
18 DYNAMICS OF SUCCESS I Desitin Company Profile 15.11.2020 DYNAMICS OF SUCCESS Desitin Company Profile