70 April 2021 Volume 70 Issue 4

4 19.81919.819 oue7 Ise4 Pages 631–814 Issue 4 Volume 70 Contents Volume 70 Issue 4 | April 2021

GUT Commentaries Gut microbiota 631 Epidemiology of gastroparesis: important 687 Location-specific cell identity rather than answers and still more questions exposure to GI microbiota defines many S Dilmaghani, M Camilleri innate immune signalling cascades in the gut April 2021 epithelium

632 COVID-19 and IBD drugs: should we change O Kayisoglu, F Weiss, C Niklas, I Pierotti, Gut: first published as on 1 April 2021. Downloaded from Bow bridge, Central Park, New York City. Read in this issue the important anything at the moment? M Pompaiah, N Wallaschek, C-T Germer, paper by Ungaro et al examining the C W Lees, P M Irving, L Beaugerie A Wiegering, S Bartfeld effect of IBD medications on COVID-19 outcomes 698 Gut microbiota composition reflects disease An international journal of severity and dysfunctional immune responses in gastroenterology and hepatology Leading article : 19.819 635 SARS-CoV-2 vaccination for patients patients with COVID-19 Editor with inflammatory bowel diseases: Y K Yeoh, T Zuo, G C-Y Lui, F Zhang, Q Liu, Emad El-Omar (Australia) recommendations from an international A YL Li, A CK Chung, C P Cheung, E YK Tso, Deputy Editor (Hepatology) K SC Fung, V Chan, L Ling, G Joynt, D S-C Hui, Alexander Gerbes (Germany) consensus meeting K M Chow, S S S Ng, T C-M Li, R WY Ng, Deputy Editor (Luminal ­ C A Siegel, G Y Melmed, D PB McGovern, V Rai, T CF Yip, G L-H Wong, F KL Chan, C K Wong, Gastroenterology) F Krammer, D T Rubin, M T Abreu, M C Dubinsky, William Grady (USA) P KS Chan, S C Ng on behalf of the International Organization for the Deputy Editor (Endoscopy) Thomas Rosch (Germany) Study of Inflammatory Bowel Disease (IOIBD) Associate Editors Guy Boeckxstaens (Belguim) GI bleeding Patrice Cani (Belgium) Jean-Francois Dufour (Switzerland) Endoscopy news 707 ABC score: a new risk score that accurately Thomas Gress (Germany) 641 Real-time unblinding for validation of a new predicts mortality in acute upper and lower Christian Jobin (USA) Ernst Kuipers (The Netherlands) CADe tool for colorectal polyp detection gastrointestinal bleeding: an international Markus Neurath (Germany) P Sinonquel, T Eelbode, C Hassan, G Antonelli, multicentre study

Siew C Ng (Hong Kong) F Filosofi, H Neumann, I Demedts, P Roelandt, S B Laursen, K Oakland, L Laine, V Bieber, http://gut.bmj.com/ Francisco Real (Spain) F Maes, R Bisschops Robert Thimme (Germany) R Marmo, E Redondo-Cerezo, H R Dalton, J Ngu, Herbert Tilg (Austria) M Schultz, M Soncini, I Gralnek, V Jairath, Fabien Zoulim (France) I A Murray, A J Stanley Artificial Intelligence/ Machine Learning Editor Stomach Akbar Waljee (USA) 644 Epidemiology and outcomes of gastroparesis, 717 Major GI bleeding in older persons using aspirin: Statistics Editors as documented in general practice records, in incidence and risk factors in the ASPREE Ruben Hernaez (USA) randomised controlled trial on September 25, 2021 by guest. Protected copyright. Susan Hutfless (USA) the Education and Digital Media Editor Y Ye, B Jiang, S Manne, P L Moses, C Almansa, S E Mahady, K L Margolis, A Chan, G Polekhina, Philip Smith (UK) D Bennett, P Dolin, A C Ford R L Woods, R Wolfe, M R Nelson, J E Lockery, Editorial Office E M Wood, C Reid, M E Ernst, A Murray, Gut LTP Thao, J J McNeil BMJ Journals 654 Mist1+ gastric isthmus stem cells are BMA House, Tavistock Square regulated by Wnt5a and expand in response to London, WC1H 9JR, UK E: [email protected] injury and inflammation in mice ISSN: 0017-5749 (print) H Nienhüser, W Kim, E Malagola, T Ruan, ISSN: 1468-3288 (online) G Valenti, M Middelhoff, A Bass, C J Der, Y Hayakawa, T C Wang Disclaimer: The Editor of Gut has been granted editorial freedom and Gut is published in accordance with editorial guidelines issued by the World Association of Medical Editors and the Committee on Publication Ethics. Gut is primarily intended for healthcare professionals and its content is for Inflammatory bowel disease information only. The Journal is published without any guarantee as to its accuracy or completeness and any 666 Angiogenin maintains gut microbe homeostasis representations or warranties are expressly excluded MORE CONTENTS ► to the fullest extent permitted by law. Readers are by balancing α-Proteobacteria and advised to independently verify any information on which they choose to rely. Acceptance of advertising Lachnospiraceae by Gut does not imply endorsement. Neither BSG nor D Sun, R Bai, W Zhou, Z Yao, Y Liu, S Tang, This article has been chosen by the Editor to be of special ­interest BMJ Publishing Group Limited shall have any liability for or importance and is freely available online. any loss, injury or damage howsoever arising from Gut X Ge, L Luo, C Luo, G Hu, J Sheng, Z Xu (except for liability which cannot be legally excluded). This article has been made freely available online under the BMJ Copyright © 2021 BMJ Publishing Group Ltd and British Society of Gastroenterology. All rights 677 Thiopurine monotherapy is effective in Journals scheme. reserved; no part of this publication may be See http://authors.bmj.com/open-access/ reproduced in any form without permission. Gut ulcerative colitis but significantly less so in is published by BMJ Publishing Group Ltd, typeset by Exeter Premedia Services Private Ltd, Chennai, Crohn’s disease: long-term outcomes for 11 928 India and printed in the UK on acid-free paper Gut is published by BMJ Publishing Group Ltd, typeset patients in the UK inflammatory bowel disease Member since 2008 by Exeter Premedia Services Private Ltd, Chennai, JM00004 India and printed in the UK on acid-free paper bioresource This journal is a member of and subscribes to the principles of the Gut (ISSN: 0017-5749) (USPS 2278) is published E Stournaras, W Qian, A Pappas, Y Y Hong, Committee on Publication Ethics bimonthly by BMJ Publishing Group Ltd, BMA House,Tavistock Square, WC1H 9JR London. Airfreight R Shawky, UK IBD BioResource Investigators, www.publicationethics.org and mailing in the USA by agent named World T Raine, M Parkes Container Inc, 150-15, 183rd Street, Jamaica, NY 11413, USA. Periodicals postage paid at Brooklyn, NY 11256. US Postmaster: Send address changes to Gut, World Container Inc, 150-15, 183rd Street, Jamaica, NY 11413, USA. Subscription records are maintained at BMA House, Tavistock Square WC1H 9HR Lodnon. Air Business Ltd is acting as our mailing agent. Contents Volume 70 Issue 4 | GUT April 2021

COVID-19 775 Role of serum HBV RNA and hepatitis B surface 725 Effect of IBD medications on COVID-19 antigen levels in identifying Asian patients with outcomes: results from an international chronic hepatitis B suitable for entecavir cessation registry W-K Seto, K SH Liu, L-Y Mak, G Cloherty, R C Ungaro, E J Brenner, R B Gearry, G G Kaplan, D K-H Wong, J Gersch, Y-F Lam, K-S Cheung, M Kissous-Hunt, J D Lewis, S C Ng, N Chow, K-L Ko, W-P To, J Fung, M-F Yuen

J-F Rahier, W Reinisch, F Steinwurz, Gut: first published as on 1 April 2021. Downloaded from F E Underwood, X Zhang, J-F Colombel, M D Kappelman Recent advances in basic science 784 MicroRNAs as regulators, biomarkers and 733 Liver injury is independently associated with therapeutic targets in liver diseases adverse clinical outcomes in patients with X Wang, Y He, B Mackowiak, B Gao COVID-19 T C-F Yip, G C-Y Lui, V W-S Wong, V C-Y Chow, T H-Y Ho, T C-M Li, Y-K Tse, D S-C Hui, Recent advances in clinical practice H L-Y Chan, G L-H Wong 796 Emerging treatment options for extraintestinal manifestations in IBD T Greuter, F Rieder, T Kucharzik, L Peyrin-Biroulet, A M Schoepfer, D T Rubin, S R Vavricka Pancreas 743 Synergistic targeting and resistance to JournalScan PARP inhibition in DNA damage repair- 803 GI highlights from the literature deficient pancreatic cancer P J Smith J Gout, L Perkhofer, M Morawe, F Arnold, M Ihle, S Biber, S Lange, E Roger, J M Kraus, K Stifter, S A Hahn, A Zamperone, T Engleitner, M Müller, PostScript K Walter, E Rodriguez-Aznar, B Sainz Jr, 806 Letters http://gut.bmj.com/ P C Hermann, E Hessmann, S Müller, N Azoitei, A Lechel, S Liebau, M Wagner, D M Simeone, H A Kestler, T Seufferlein, L Wiesmüller, R Rad, P-O Frappart, A Kleger Editor’s quiz: GI snapshot 640 Dysphagia in a young female patient: it’s not always that simple on September 25, 2021 by guest. Protected copyright. Hepatology J Carvão, A Peixoto, E Rios, G Macedo 761 Dietary cholesterol drives fatty liver- associated liver cancer by modulating gut Electronic page microbiota and metabolites X Zhang, O O Coker, E SH Chu, K Fu, e2 Correction: British Society of Gastroenterology H C H Lau, Y-X Wang, A W H Chan, H Wei, consensus guidelines on the management of X Yang, J J Y Sung, J Yu inflammatory bowel disease in adults