DOCSLIB.ORG

Long-Course Neoadjuvant Chemoradiotherapy with Versus

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Long-Course Neoadjuvant Chemoradiotherapy with Versus Wang et al. Radiation Oncology (2019) 14:215 https://doi.org/10.1186/s13014-019-1420-z RESEARCH Open Access Long-course neoadjuvant chemoradiotherapy with versus without a concomitant boost in locally advanced rectal cancer: a randomized, multicenter, phase II trial (FDRT-002) Jingwen Wang1,2†, Yun Guan3,4†, Weilie Gu1,5, Senxiang Yan6, Juying Zhou7, Dan Huang1,8, Tong Tong1,9, Chao Li10,11, Sanjun Cai1,5, Zhen Zhang1,2* and Ji Zhu1,2* Abstract Background: This study was designed to explore whether an intensified chemoradiotherapy (CRT) led to a better clinical outcome in locally advanced rectal cancer. Methods: Patients with stage II/III rectal cancer were randomly allocated to receive either pelvic intensity- modulated radiation therapy (IMRT) of 50 Gy/25Fx concurrently with capecitabine and oxaliplatin (Arm A), or pelvic radiation of 50 Gy/25Fx with a concomitant boost of 5 Gy to the primary lesion, followed by a cycle of XELOX 2 weeks after the end of CRT (Arm B). All patients were planned to receive a definitive operation 8 weeks after the completion of CRT and a total of six perioperative chemotherapy cycles of capecitabine and oxaliplatin regardless of pathological result. Pathological complete response (ypCR) was the primary endpoint. Results: From February 2010 to December 2011, 120 patients from three centers were enrolled in this study. Ninety- five percent patients completed a full-dose chemoradiotherapy as planning. Then 53 and 57 patients received a radical surgery, and 8 and 14 cases were confirmed as ypCR in two groups (P = 0.157). The other 10 patients failed to receive a definitive resection because of unresectable disease. Similar toxicities were observed between two groups and more incision healing delay were found in Arm B (3 vs.13, P = 0.011). No statistical differences were observed in local-regional control (P = 0.856), disease-free survival (P = 0.349) and overall survival (P = 0.553). Mesorectal fascia (MRF) involvement was an independent prognostic factor for survival in multivariate analysis. Conclusions: A concomitant boost to oxalipatin-combined preoperative chemoradiotherapy demonstrated a slightly higher pCR rate but delayed incision healing after surgery. The impact of MRF involvement on survival merits further investigations. Trial registration: NCT01064999 (ClinicalTrials.gov). Keywords: Rectal cancer, Neoadjuvant chemoradiotherapy, Intensity-modulated radiation therapy * Correspondence: [email protected]; [email protected] †Jingwen Wang and Yun Guan contributed equally to this work. 1Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China Full list of author information is available at the end of the article © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Wang et al. Radiation Oncology (2019) 14:215 Page 2 of 9 Introduction disorders. Informed consent must be obtained from With report of results from a series of large randomized every patient before randomization. The procedure of clinical trials comparing neoadjuvant pelvic radiotherapy random assignment was performed centrally at the (RT) alone versus RT plus concurrent 5-fluorouracil (5- Fudan University Shanghai Cancer Center. FU), the standard modality for stage II/III rectal cancer has shifted to preoperative chemoradiotherapy (CRT), Treatment schedule followed by total mesorectal excision (TME) and postop- The IMRT technique and tumor volumes definition has erative chemotherapy, which leads to preservation of been described in our previous trial [9]. For Arm A, the normal tissue, improvement of tumor regression and ex- planning dose to the PTV2 (pelvis) were 50 Gy in 25 cellent local control [1]. fractions, five times per week (Monday through Friday) The German CAO/ARO/AIO-94 study is the mile- over 5 weeks. For Arm B, the planning doses to the stone of preoperative CRT [2]. Patients who received PTV1 (primary tumor) and PTV2 were 55 Gy and 50 Gy preoperative RT in the study had superior local control in 25 fractions. Electronic portal imaging device (EPID) and reduced toxicity compared with patients in the post- films were used to verify the isocenter and positioning of operative group. Subsequently, the EORTC 22921 trial each patient for the anterior and lateral gantry positions. [3] and FFCD9203 trial [4] suggested 5-FU-based CRT Capecitabine and oxaliplatin were given in combin- resulted in a lower local recurrence rate compared with ation with pelvic radiotherapy. The concurrent chemo- long-course RT alone, in spite of similar long-term sur- therapy regimen was same in both Arms. Capecitabine vival. Furthermore, in EORTC 22921 trial, the ypT0–2 of 625 mg/m2 was given twice daily from Monday to Fri- group had a significant better OS and DFS than the day, and oxaliplatin was administered at a fix dose of 50 ypT3–4 group [5]. Similar results were also observed in mg/m2/week throughout the entire course of CRT. Two MDACC’s retrospective study, where tumor regression weeks after the end of CRT, one additional cycle of could be converted to a better long-term prognosis [6]. XELOX (capecitabine 1000 mg/m2 twice daily on day 1– Moreover, in a pooled analysis [7], it was reported that 14 and oxaliplatin 130 mg/m2 on day 1) was scheduled patients with pCR after CRT have better long-term out- for patients in Arm B (Fig. 1). come than do those without pCR (5-year crude DFS: After the completion of CRT, patients were planned to 83∙3% vs 65∙6%). Therefore, in some views, tumor down- undergo TME 8 weeks later, while the operation type, staging, especially pCR, was regarded as a goal in neoad- such as abdominal-perineal resection (APR) or low an- juvant treatment of locally advanced rectal cancer, which terior resection (LAR), and whether to perform a tem- motivated the combination of systemic chemotherapy porary colostomy, were left to the surgeon to decide. All and advanced RT technique in this approaches. patients were recommended to receive a total of six cy- In our center, previous phase II studies reported that cles of XELOX in perioperative period, regardless of oxaliplatin plus 5-FU-based CRT showed good tumor their pathological features. responses and tolerable toxicities [8–10]. Higher radi- ation dose was reported to contribute to tumor downsta- Treatment evaluation and follow-up ging in literatures [11–13]. Therefore, we designed this Baseline evaluation included a comprehensive medical randomized trial to explore whether a combined regi- history collection, digital examination, colonoscopy men of oxaliplatin-added chemoradiotherapy and a con- and biopsy, computed tomography (CT) scanning of comitant boost to the primary tumor would further lead chest and abdomen, and magnetic resonance imaging to a better clinical outcome. (MRI) of pelvis. Endorectal ultrasound (EUS) and posi- tron emission tomography (PET) were not routinely Patients and methods recommended. Patient eligibility Pathologic examination of surgical specimens was The main inclusion criteria of this study were as follows: performed in accordance with the American Joint (1) newly diagnosed rectal adenocarcinoma; (2) aged be- Committee on Cancer (AJCC, Version 7) [14]. If less tween 18 and 75 years old; (3) tumor located within 12 than 12 lymph nodes were found during standard cm from anal verge; (4) clinically staged T3–4 and/or examination for resected lymph nodes, two pathologists N+; (5) no evidence of distant metastases; (6) had Kar- needed to double check to verify the number of lymph nofsky Performance Status score of 60 or more; and (7) nodes. The tumor regression grade (TRG) after chemo- had adequate hematologic, renal and hepatic function. radiotherapy was recorded according to the AJCC TRG Patients were excluded if they had history of malignant system. TRG 0: Complete tumor response-no viable tumor but not including cured skin cancer or cervical cancer cells; TRG 1: Moderate response-single or small cancer in situ, had inflammatory bowel disease, ischemic groups of tumor cells; TRG 2: Minimal response- heart disease, peripheral neuropathy, or psychological residual cancer outgrown by fibrosis; TRG 3: Poor Wang et al. Radiation Oncology (2019) 14:215 Page 3 of 9 Fig. 1 Treatment schedules response-minimal or no tumor cells killed. PCR was de- Comparisons between two groups were performed using fined as the absence of viable tumor cells in the resec- χ2 tests for categorical variable. Survival curves were es- tion specimens including the primary tumor and lymph timated using the Kaplan-Meier method and compared nodes (ypT0N0), and near-pCR was defined as with Log-rank test. Cox proportional hazards regression ypT0N1a or TRG1 in our study. Those with a margin was used for univariate and multivariate modeling and of circumferential rectal margin (CRM) < 1 mm were for examining the prognostic significance of the variables marked in positive status [15]. identified in the model. P values of less than 0.05 were Acute toxicities were defined as toxicities occurred taken to indicate statistically significant differences. during the entire course of CRT and were evaluated weekly according to the National Cancer Institute Com- Results mon Toxicity Criteria (CTCAE 4.0). Follow-up was Baseline characteristics scheduled every 3 months during the first 2 years after From February 2010 to December 2011, 120 eligible pa- surgery, and then every 6 months over the next 3 years. tients in three centers (Fudan University Shanghai Cancer After 5 years, the frequency of follow-up was extended Center, Shanghai, China; The First Affiliated Hospital, to once each year.
Load more

Recommended publications
  • Name of Recognized Medical Schools (Foreign)
    1 Name of Recognized Medical Schools (Foreign) Expired AUSTRALIA 1 School of Medicine, Faculty of Heath, University of Tasmania, Tasmania, Australia (5 years Program) 9 Jan Main Affiliated Hospitals 2021 1. Royal H obart Hospital 2. Launceston Gen Hospital 3. NWest Region Hospital 2 Melbourne Medical School, University of Melbourne, Victoria, Australia (4 years Program) 1 Mar Main Affiliated Hospitals 2022 1. St. Vincent’s Public Hospital 2. Epworth Hospital Richmond 3. Austin Health Hospital 4. Bendigo Hospital 5. Western Health (Sunshine, Footscray & Williamstown) 6. Royal Melbourne Hospital Affiliated Hospitals 1. Pater MacCallum Cancer Centre 2. Epworth Hospital Freemasons 3. The Royal Women’s Hospital 4. Mercy Hospital for Women 5. The Northern Hospital 6. Goulburn Valley Health 7. Northeast Health 8. Royal Children’s Hospital 3 School of Medicine and Public Health, University of Newcastle, New South Wales, Australia (5 years Program) 3 May Main Affiliated Hospitals 2022 1.Gosford School 2. John Hunter Hospital Affiliated Hospitals 1. Wyong Hospital 2. Calvary Mater Hospital 3. Belmont Hospital 4. Maitland Hospital 5. Manning Base Hospital & University of Newcastle Department of Rural Health 6. Tamworth Hospital 7. Armidale Hospital 4 Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia (4 and 5 years Program) 8 Nov Main Affiliated Hospitals 1. Eastern Health Clinical School: EHCS 5 Hospitals 2022 2. Southern School for Clinical Sciences: SCS 5 Hospitals 3. Central Clinical School จ ำนวน 6 Hospitals 4. School of Rural Health จ ำนวน 7 Hospital 5 Sydney School of Medicine (Sydney Medical School), Faculty of Medicine and Health, University of Sydney, Australia 12 Dec (4 years Program) 2023 2 Main Affiliated Hospitals 1.
    [Show full text]
  • The 2 Asia Medical Week
    SYNERGIZED INNOVATION & SUSTAINED EVOLUTION THE 2nd ASIA MEDICAL WEEK ASIAN MEDICAL INNOVATION & DEVELOPMENT FORUM 2019 Fudan Zhongshan International Oncology Summit & Annual Conference of Fudan Zhongshan Cancer Center Shanghai / Shenzhen Oct.19-21 2019 ACTIVITIES RECAP 2018 South Korea 2019 Statistics 11 4 4 1000+ 30 81% Sub-Forums Private Sessions Clinial Exchange Visit Attendees Countries & Regions Top Management Presidents, Vice-Presidents, CEOs, Directors or Officers from Governments, MOHs & Hospitals. Overseas Visitors Armenia Australia Bangladesh Belarus Brazil China Egypt France Greece India Indonesia Italy Japan Kazakhstan Kenya Malaysia Myanmar Northern Cyprus Pakistan Philippines Russia Singapore South Korea Sri Lanka Thailand Turkey Ukraine UK US Vietnam Launching Ceremony Dear Professors, We take a great pleasure in inviting you to the 2019 Asian Medical Week, which is held in Shanghai from October 19th to October 21st , 2019. Asia Medical Week is a prominent academic event for promoting medical communication and cooperation in the Asia-Pacific region. With the theme focusing on "Medical Innovation & Development", 2019 Asia Medical Week is dedicated to providing an effective communication platform for international healthcare community and industry to showcase China’s latest oncology, promote sharing for high-quality healthcare resources and advocate high-tech cooperation for modern medicine. Towards a vision of "Collaborative Innovation, Sustainable Progress", Fudan University Zhongshan Hospital and Fudan University Zhong Shan Hospital Cancer Center (FUZSCC) will host the 2019 Asian Medical Week - - Medical Innovation & Development Forum, featuring 2019 Fudan Zhongshan International Oncology Summit, in concurrent with the annual meeting of FUZSCC. To pace the internationalization and development of China healthcare system through in-depth communication and collaboration between Asia-Pacific countries, the program will focus on the newest advances in tumor management and establish “the Belt and Road” Oncology Alliance during the event.
    [Show full text]
  • Differences in Treatment Effect Size Between Progression-Free Survival
    2572 Original Article Differences in treatment effect size between progression-free survival and overall survival in anti-PD-1/PD-L1 inhibitors-based trials in advanced NSCLC: a systematic review and meta-analysis Zhirui Zhou1#, Shengxiang Ren2#, Lingxiao Chen3, Caicun Zhou2, Tao Jiang2,4 1Radiation Oncology Center, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China; 2Department of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, China; 3Institute of Bone and Joint Research, Kolling Institute, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia; 4Department of Pulmonary Medicine, Shanghai Respiratory Research Institute, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China Contributions: (I) Conception and design: T Jiang, S Ren, C Zhou; (II) Administrative support: T Jiang, S Ren, C Zhou; (III) Provision of study materials or patients: T Jiang, S Ren, C Zhou; (IV) Collection and assembly of data: T Jiang, Z Zhou, L Chen; (V) Data analysis and interpretation: T Jiang, Z Zhou, L Chen; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. #These authors contributed equally to this work. Correspondence to: Tao Jiang, PhD. Department of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, No. 507, Zheng Min Road, Shanghai 200433, China; Department of Pulmonary Medicine, Shanghai Respiratory Research Institute, Zhongshan Hospital Affiliated to Fudan University, No. 180, Fenglin Road, Shanghai 200032, China. Email: [email protected]. Background: To investigate the differences in treatment effect sizes between progression-free survival (PFS) and overall survival (OS) in advanced non-small cell lung cancer (NSCLC) treated with programmed cell death 1 (PD-1) and its ligand (PD-L1) blockade-based treatments.
    [Show full text]
  • The Cost of Alzheimer's Disease in China and Re-Estimation of Costs Worldwide
    Alzheimer’s & Dementia 14 (2018) 483-491 Featured Article The cost of Alzheimer’s disease in China and re-estimation of costs worldwide Jianping Jiaa,b,c,d,e,*, Cuibai Weia,*, Shuoqi Chena, Fangyu Lia, Yi Tanga, Wei Qina, Lina Zhaoa, Hongmei Jina, Hui Xua, Fen Wanga, Aihong Zhoua, Xiumei Zuoa, Liyong Wua, Ying Hana, Yue Hana, Liyuan Huanga, Qi Wanga, Dan Lia, Changbiao Chua, Lu Shia, Min Gonga, Yifeng Duf, Jiewen Zhangg, Junjian Zhangh, Chunkui Zhoui, Jihui Lvj, Yang Lvk, Haiqun Xiel, Yong Jim, Fang Lin, Enyan Yuo, Benyan Luop, Yanjiang Wangq, Shanshan Yangr, Qiumin Qus, Qihao Guot, Furu Liangu, Jintao Zhangv, Lan Tanw, Lu Shenx, Kunnan Zhangy, Jinbiao Zhangz, Dantao Pengaa, Muni Tangab, Peiyuan Lvac, Boyan Fangad, Lan Chuae, Longfei Jiaaf, Serge Gauthierag,* aDepartment of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China bBeijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China cCenter of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China dKey Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China eNational Clinical Research Center for Geriatric Disorders, Beijing, China fDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, China gDepartment of Neurology, Henan Provincial People’s Hospital, Zhengzhou, China hDepartment of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, China iDepartment of Neurology, The First Teaching Hospital of Jilin University, Changchun, China jDementia Unit, Beijing Geriatric Hospital, Beijing,
    [Show full text]
  • Study Protocol of a Randomized Phase III Trial of Comparing Preoperative
    Liu et al. BMC Cancer (2019) 19:606 https://doi.org/10.1186/s12885-019-5728-8 STUDY PROTOCOL Open Access Study protocol of a randomized phase III trial of comparing preoperative chemoradiation with preoperative chemotherapy in patients with locally advanced gastric cancer or esophagogastric junction adenocarcinoma: PREACT Xiaowen Liu1,2, Jiejie Jin1,2, Hong Cai1,2, Hua Huang1,2, Guangfa Zhao1,2, Ye Zhou1,2, Jianghong Wu1,2, Chunyan Du1,2, Ziwen Long1,2, Yantian Fang1,2, Mingze Ma1,2, Guichao Li2,3, Menglong Zhou2,3, Jiliang Yin2,4, Xiaodong Zhu2,4, Ji zhu2,3, Weiqi Sheng2,5, Dan Huang2,5, Hui Zhu2,6, Zhaozhen Zhang2,7,QiLu2,8, Li Xie9, Zhen Zhang2,3* and Yanong Wang1,2* Abstract Background: The prognosis of patients with locally advanced gastric cancer or esophagogastric junction adenocarcinoma is still dismal. There are no standard treatment strategies for these patients. Multidisciplinary team (MDT) approach is a good choice for making a high-quality decision. Generally, MDT will recommend these patients to receive preoperative chemotherapy or preoperative chemoradiation based on all kinds of treatment guidelines. However, the preferred preoperative treatment is still not established. In order to solve this problem, we carry out this randomized phase III trial of comparing preoperative chemoradiation with preoperative chemotherapy in patients with locally advanced gastric cancer or esophagogastric junction adenocarcinoma. Methods: Eligible patients with locally advanced gastric cancer or esophagogastric junction adenocarcinoma are randomized to receive preoperative chemoradiation or preoperative chemotherapy, followed by surgery and postoperative chemotherapy. In the preoperative chemoradiation arm (Pre-CRT), patients receive two cycles of S-1 and oxaliplatin (SOX), chemoradiation, then followed by surgery and three more cycles of SOX chemotherapy.
    [Show full text]
  • Honor Rolls of Best Hospitals in China Released
    News Page 1 of 23 Honor rolls of best hospitals in China released Luna Young, Molly J. Wang Editorial Office,Journal of Hospital Management and Health Policy, Nanjing 210000, China Correspondence to: Molly J. Wang, Senior Editor. Editorial Office, Journal of Hospital Management and Health Policy, Nanjing 210000, China. Email: [email protected]. Received: 24 November 2017; Accepted: 03 December 2017; Published: 08 December 2017. doi: 10.21037/jhmhp.2017.12.01 View this article at: http://dx.doi.org/10.21037/jhmhp.2017.12.01 On November 11, 2017, the Honor Roll of the Best Best Comprehensive Hospitals in 2016. Comprehensive Hospitals in 2016 has been released by the In the meantime, the Honor Roll of Best Hospitals of Hospital Management Institute, Fudan University, China. Specialties in 2016 has been unveiled as well. Notably, The Honor Roll recognizes 100 hospitals for their altogether top 10 hospitals are selected in each of these exceptional comprehensive abilities where reputation of 37 specialties. The specialties range from Pathology, specialties and scientific research ability are among the Radiology, Pulmonology, Stomatology, Urology and factors predominantly weighed. Psychiatry and others with a rather comprehensive As usual, Peking Union Medical College Hospital, coverage on our daily needs. With no doubt, Peking Union West China Hospital of Sichuan University and General Medical College Hospital, West China Hospital of Sichuan Hospital of the People’s Liberation Army easily made University and General Hospital of the People’s Liberation the list, respectively ranking the top 3. Moreover, there Army, the top 3 comprehensive hospitals, are leading the are several hospitals rising greatly in the list, such as most entries of the specialties among the list.
    [Show full text]
  • Famous Hospitals in Shanghai City
    Famous Hospitals in Shanghai City Franco Naccarella Medical service system and pertinent bureau • There are four medical service systems in Shanghai. • They are Fu Dan University, Shanghai Jiao Tong University, Tong Jing University, Shanghai Traditional Chinese Medical School • Shanghai Bureau of health make the rule of hearth care and supervise all the hospitals attached to their university. Top Ten Hospital Fudan University • Zhongshan Hospital • Huashan Hospital Shanghai Jiao Tong University • First People’s Hospital • Sixth People’s Hospital • Renji Hospital • Ruijin Hospital • Xinhua Hospital • Nineth People’s Hospital Second Military Medical University • Changhai Hospital • Changzheng Hospital Zhongshan hospital Zhongshan hospital • Zhongshan Hospital was founded in 1936 in commemoration of the late Dr. Sun Yat- sen. It is a leading hospital in China and was awarded "The Best 100 Hospitals" in 1999 • The discipline of Zhongshan Hospital is Prudent, Practicality, Unity and Offering Zhongshan hospital www.zs-hospital.sh.cn • Cardiology, Hepatology,Nephrology and Respiratory diseases are their leading subject • Cardiology research institute is well known in the world. They performed the first cardiac catheter examination in China Zhongshan hospital • Cardiology department is the largest in Shanghai area. They have three catheter room, non-invasive cardiac exam center including treadmill exercise test, tilt table test, holter monitor, ABPM and advanced Echo center. • EP center have sophisticated EP console. They own CARTO-XP 3 dimension electroanatomy mapping equipment Zhongshan hospital • Their emergency PCI number is the largest in Shanghai area, about 400 cases for one year, and more than 1000 cases of selective PCI cases every year • The cardiolog department is also well known for myocardiopathy and myocarditis research • They are number of national qualified clinical medicine trial base and national EP training base Zhongshan hospital • The chief of cardiolgy is prof.
    [Show full text]
  • NCI Designated Cancer Centers International Activities
    International Activities of NCI-Designated Cancer Centers Summary Report March 2014 This report is not a comprehensive summary of the international efforts of NCI-Designated Cancer Centers and not all of the efforts outlined in this report are NCI or NIH-funded. Rather, this report summarizes information that was provided by Cancer Centers who responded to requests from the NCI Center for Global Health for information on international activities. This is an ongoing data- collection effort, the data collection status for individual cancer centers can be found in Appendix A. Any additions or corrections are welcome. Please contact Rebecca Minneman ([email protected]). Table of Contents Abramson Cancer Center - University of Pennsylvania ....................................................................................4 Albert Einstein Cancer Center - Yeshiva University ..........................................................................................4 Alvin J. Siteman Cancer Center - Washington University ..................................................................................5 The Barbara Ann Karmanos Cancer Institute – Wayne State University ............................................................6 The Cancer Therapy & Research Center (CTRC) at the University of Texas Health Science Center at San Antonio (UTHSCSA) ................................................................................................................................................... 10 Case Comprehensive Cancer Center - Case Western
    [Show full text]
  • ≤2 Cm), Non-Functioning Pancreatic Neuroendocrine Tumors: a Consensus Statement by the Chinese Study Group for Neuroendocrine Tumors (CSNET
    INTERNATIONAL JOURNAL OF ONCOLOGY 50: 567-574, 2017 Surgery management for sporadic small (≤2 cm), non-functioning pancreatic neuroendocrine tumors: A consensus statement by the Chinese Study Group for Neuroendocrine Tumors (CSNET) GUANG YANG1*, MENG JI1*, JIE CHEN2, RUFU CHEN3, YE CHEN4, DELIANG FU5, BAOHUA HOU6, HEGUANG HUANG7, LIMING JIANG8, KAIZHOU JIN9, NENGWEN KE10, YING LI11, YONG LI6, HOUJIE LIANG12, AN'AN LIU1, JIE LUO13, QUANXING NI9, CHENGWEI SHAO14, BOYONG SHEN15, WEIQI SHENG16, BIN SONG17, JIAN SUN3, CHUNLU TAN10, HUANGYING TAN18, QIYUN TANG19, YINGMEI TANG20, XIAODONG TIAN21, JIAN Wang22, JIE Wang23, WEI Wang24, WEI Wang25, ZHENG WU26, JIN XU9, QIANG YAN27, NING YANG28, YINMO YANG21, XIAOYU YIN29, XIANJUN YU9, CHUNHUI YUAN30, SHAN ZENG31, GUOCHAO ZHANG32, RENCHAO ZHANG33, ZHIWEI ZHOU25, ZHAOHUI ZHU34 and CHENGHAO SHAO1 1Department of General Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai; 2Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong; 3Department of Hepatopancreatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong; 4Department of Gastroenterology, Nanfang Hospial, Southern Medical University, Guangzhou, Guangdong; 5Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai; 6Department of General Surgery, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong; 7Department
    [Show full text]
  • The Clinical Utility of CA125/MUC16 in Pancreatic Cancer
    900 INTERNATIONAL JOURNAL OF ONCOLOGY 48: 900-907, 2016 The clinical utility of CA125/MUC16 in pancreatic cancer: A consensus of diagnostic, prognostic and predictive updates by the Chinese Study Group for Pancreatic Cancer (CSPAC) LIANG LIU1-3*, JINFENG XIANG1-3*, RUFU CHEN4, DELIANG FU5, DEFEI HONG6, JIHUI HAO7, YIXIONG LI8, Jiangtao LI9, SHENGPING LI10, YIPING MOU11, GANG MAI12, QUANXING NI1-3, LI PENG13, RENYI QIN14, HONGGANG QIAN15, CHENGHAO SHAO16, BEI SUN17, YONGWEI SUN18, MIN TAO19, BOLE TIAN20, HONGXIA Wang21, JIAN Wang18, LIWEI Wang22, WEI Wang23, WEILIN Wang24, JUN ZHANG25, GANG ZHAO26, JUN ZHOU27 and XIANJUN YU1-3, FOR THE CHINESE STUDY GROUP FOR Pancreatic CANCER (CSPAC) 1Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center; 2Department of Oncology, Shanghai Medical College, 3Pancreatic Cancer Institute, Fudan University, Shanghai; 4Department of Pancreaticobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong; 5Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai; 6Department of Hepatobiliary and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang; 7Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin; 8Department of Pancreatic-Bililary Surgery, Xiangya Hospital, Central South University, Changsha, Hunan; 9Department of Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou; 10Department
    [Show full text]
  • 2020.02.19.20025031V1.Full.Pdf
    medRxiv preprint doi: https://doi.org/10.1101/2020.02.19.20025031; this version posted February 23, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. 1 Title: A descriptive study of the impact of diseases control and prevention on the epidemics 2 dynamics and clinical features of SARS-CoV-2 outbreak in Shanghai, lessons learned for 3 metropolis epidemics prevention. 4 5 6 Hongzhou Lu2, Jingwen Ai1, Yinzhong Shen2, Yang Li1, Tao Li2, Xian Zhou1, Haocheng 7 Zhang1，Qiran Zhang1，Yun Ling2, Sheng Wang3, Hongping Qu4, Yuan Gao6, Yingchuan 8 Li7, Kanglong Yu8, Duming Zhu5, Hecheng Zhu9, Rui Tian8, Mei Zeng10, Qiang Li11, Yuanlin 9 Song5, Xiangyang Li12, Jinfu Xu13, Jie Xu14, Enqiang Mao4, Bijie Hu5, Xin Li5, Lei Zhu5, 10 Wenhong Zhang1 on behalf of the Shanghai Clinical Treatment Expert Group for SARS- 11 CoV-2 12 13 Hongzhou Lu, Jingwen Ai, Yinzhong Shen, Yang Li contributed equally to this manuscript 14 15 Correspondence: 16 Wenhong Zhang, Department of Infectious Diseases, Fudan University, Shanghai 200040. 17 Mailing address: 12 Wulumuqi Zhong Road, Shanghai, China. Tel: +86-21-52888123. Fax: +86- 18 21-62489015. Email: [email protected]. 19 20 Affiliations: 21 1. Department of infectious disease, Huashan Hospital of Fudan University, Shanghai, China 22 2. Shanghai Public Health Clinical Center, Fudan University, Shanghai, China 23 3. Shanghai Tenth People’s Hospital of Tongji University, Shanghai, China 24 4. Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 25 5.
    [Show full text]
  • Hospital Network List
    Hospital Network List ( : 2019 7 ) (The Latest Updated: July 2019) AXA General Insurance Hong Kong Limited 38 5 5/F, AXA Southside, 38 Wong Chuk Hang Road, Wong Chuk Hang, Hong Kong Tel: (852) 2523 3061 Fax: (852) 2810 0706 Email: [email protected] www.axa.com.hk Index / Province/City Page Shandong 2 Shanghai 2 - 3 Tianjin 3 Sichuan 3 Beijing 3 - 5 Jiangsu 5 - 6 Hebei 6 Chongqing 6 Shanxi 6 Zhejiang 6 Hubei 6 Hunan 6 Yunnan 6 - 7 Heilongjiang 7 Xinjiang 7 Guangxi 7 Guangdong 7 Liaoning 7 1 / Province/City Hospital Name Address 19 Shandong Qingdao women& Infants Hospital No. 19, Zhongshan Road, Shinan District, Qingdao. (3A) 105 Jinan Central Hospital No. 105, Jiefang Road, Lixia District, Jinan (3A) 16766 Shandong Qianfoshan Hospital No. 16766, Jingshi Road, Lixia District, Jinan, Shandong (3A) 5 Qingdao Municipal Hospital (East Department) No. 5, Donghaizhong Road, Shinan District, Qingdao (3A) 127 Qingdao Center Hospital No. 127, Si Liu South Road, Shibei District, Qingdao (Private) 319 Qingdao United Family Hospital No. 319, Hong Kong East Road, Laoshan District, Qingdao (Private) 1 Jinan Aima Maternity Hospital No.1, Yaotou Road, Lixia District, Jinan (Private) 8 Yantai Luye-Bobath Rehab Hospital No. 8, Haibo Road, High-tech Zone, Yantai, Shandong (3A) 16 The Affiliated Hospital of Qingdao University International Medical Center No. 16, Jiangsu Road, Shinan District, Qingdao (3A) 12 Shanghai Huashan Hospital affiliated to Fudan University No. 12, Wulumuqi Middle Road, Shanghai (Private) 170 3 Parkway Health Medical Centers – Specialty and Inpatient Center 3/F, No.170, Danshui Road, Luwan District, Shanghai (Private) 551 Shanghai East International Medical Center No.
    [Show full text]