Childhood Cancer by the ICCC, CSR 1975-2016

3.0 14.1 2.5 4.7 34.9 2.2 1.0 0.5 0.4 - 2.3 - 1.9 - 245.4 283.4 35.8 18.3 9.6 4.6 1.7 1.6 53.8 32.7 17.6 2.6 - 0.8 61.3

15-19 3.0 16.5 3.8 5.5 17.4 2.3 1.4 1.0 - - 1.7 0.8 0.9 - 153.5 174.4 35.4 22.9 7.8 2.2 1.2 1.4 27.9 12.6 12.2 2.5 - - 48.6 in situ 10-14 2.9 19.1 7.6 7.0 11.2 1.6 4.5 4.3 - 0.5 6.2 6.0 - - 131.3 145.7 44.6 36.7 4.2 1.3 0.9 1.6 16.0 3.5 8.7 3.5 - - 49.4 5-9 6.2 22.2 9.9 5.9 6.5 1.6 21.8 21.6 - 8.2 19.0 18.8 - - 218.0 227.8 91.4 76.3 10.4 0.9 1.4 2.4 9.2 0.7 6.0 2.1 - - 52.2 a 1-4 and Age at Diagnosis and Age 9.0 14.4 10.4 - 5.1 2.7 55.1 55.1 - 33.4 17.5 17.2 - - 250.9 262.4 52.6 19.7 18.2 3.4 8.3 3.0 2.3 - - - - - 43.5

c <1 0.8 - 49.5 35.4 8.3 2.4 1.6 1.8 26.6 12.5 11.0 2.6 0.2 0.4 52.4 3.9 17.5 5.9 5.6 17.5 2.0 8.6 8.3 0.3 3.3 7.1 6.3 188.1 209.1 0-19 0.4 - 54.1 41.1 7.9 1.6 1.6 1.8 17.4 5.7 8.8 2.6 0.2 0.2 49.5 4.2 18.7 7.1 5.9 11.7 1.9 11.1 10.9 0.2 4.4 8.7 8.2 168.9 184.1 Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. Group and Subgroup Group and

0-14 b For ICCC groups and subgroups that include Table 29.1 Table

d All Races, Males and Females All Races,

d Rate based on less than 16 cases for the time interval. Age-Adjusted and Age-Specific SEER Cancer Incidence Rates, 2012-2016 Rates, Incidence SEER Cancer and Age-Specific Age-Adjusted Including myelodysplastic syndromes and Group III benign brain/CNS tumors Group III benign syndromes and myelodysplastic Including By International Classification of Childhood Cancer(ICCC) of Childhood Classification By International SEER 21 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, San Jose-Monterey, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, SEER 21 areas (San Francisco, Connecticut, New Jersey, Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, Los Angeles, Alaska Native Registry, New York and Massachusetts). Georgia excluding ATL/RG, Idaho, International Classification of Childhood Cancer is based on ICD-O-3. Cancer. April 1, 2005: Vol 103, No. 7 , pg 1457-1467. International Classification of Childhood Cancer, Third Edition. Classifications are shown for invasive cases only except as noted. behavior, only invasive cases are shown except as noted. Group III and Group III subgroups include benign brain/CNS tumors. (19 age groups - Census P25-1130). Rates are per 1,000,000 and are age-adjusted to the 2000 US Std Population Statistic could not be calculated. VI(a) Nephroblastoma and other nonepithelial renal tumor VI(a) Nephroblastoma and other nonepithelial VI(b) Renal carcinoma tumors VI(c) Unspecified malignant renal III(e) Other specified intracranial/intraspinal neoplasms III(e) Other specified intracranial/intraspinal and intraspinal neoplasms III(f) Unspecified intracranial IV(a) Neuroblastoma and ganglioneuroblastoma tumors IV(b) Other peripheral nervous cell II(d) Miscellaneous lymphoreticular neoplasms II(d) Miscellaneous lymphoreticular II(e) Unspecified lymphomas tumor III(a) Ependymomas and choroid plexus III(b) Astrocytoma embryonal tumors III(c) Intracranial and intraspinal III(d) Other gliomas I(c) Chronic myeloproliferative diseases I(c) Chronic myeloproliferative syndrome and other myeloproliferative I(d) Myelodysplastic and other specified leukemias I(e) Unspecified II(a) Hodgkin lymphoma lymphoma (except Burkitt lymphoma) II(b) Non-Hodgkin II(c) Burkitt lymphoma Excluding Group III benign brain/CNS tumors Excluding Group III benign brain/CNS tumors Including Group I(a) Lymphoid leukemia leukemia I(b) Acute myeloid V Retinoblastoma VI Renal tumors IV Neuroblastoma and other peripheral nervous cell tumor IV Neuroblastoma and other peripheral III CNS and misc intracranial and intraspinal neoplasms III CNS and misc intracranial and II Lymphomas and reticuloendothelial neoplasms II Lymphomas and I Leukemia (includes myelodysplastic syndromes) I Leukemia (includes

All ICCC Groups Combined All ICCC ICCC Group and Subgroup and Subgroup ICCC Group b c d - a

SEER Cancer Statistics Review 1975-2016 National Cancer Institute 3.3 1.7 23.8 1.7 0.9 64.2 - 34.0 1.1 9.8 - 18.7 1.0 0.5 0.5 - 1.3 - 1.3 - 15.5 8.9 0.8 4.3 0.9 0.5 16.3 3.3 1.9 - 8.9 2.2 31.0

15-19 3.3 - 4.5 - - 21.1 - 9.4 0.6 3.2 - 7.6 0.5 - - - 1.0 - 0.8 - 15.2 9.3 0.5 4.6 0.7 - 13.4 4.2 1.1 - 6.1 1.9 8.2 in situ 10-14 1.6 - 1.2 - - 5.6 - 1.6 - 1.9 - 1.8 - - - - 0.9 0.5 - - 6.6 3.4 - 2.7 - - 8.8 4.5 0.8 - 2.7 0.8 2.5 5-9 1.3 1.5 1.5 - - 1.9 - - - 1.2 - - 1.0 0.9 - - 6.5 6.4 - - 1.9 - - 1.1 - - 11.1 8.0 - - 1.9 0.6 3.5 a 1-4 and Age at Diagnosis and Age 4.8 15.0 3.3 - - 3.4 ------2.5 - - - 14.5 14.5 ------16.4 4.4 4.1 - 5.7 - 20.8

c <1 0.3 0.3 - 9.8 5.6 0.4 3.2 0.5 0.2 12.7 4.8 1.3 - 5.1 1.5 12.2 2.5 1.6 7.9 0.5 0.3 23.5 0.2 11.4 0.5 4.0 0.1 7.2 0.7 0.5 2.7 2.1 0.6 0-19 0.2 0.2 - 7.9 4.4 0.2 2.8 0.4 - 11.4 5.3 1.0 - 3.9 1.2 5.9 2.3 1.5 2.5 - - 9.8 0.2 3.9 0.2 2.1 - 3.3 0.7 0.4 3.2 2.8 0.4 Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. Group and Subgroup Group and

0-14 b For ICCC groups and subgroups that include

d Table 29.1 - continued 29.1 - Table All Races, Males and Females All Races,

d Rate based on less than 16 cases for the time interval. Age-Adjusted and Age-Specific SEER Cancer Incidence Rates, 2012-2016 Rates, Incidence SEER Cancer and Age-Specific Age-Adjusted Including myelodysplastic syndromes and Group III benign brain/CNS tumors Group III benign syndromes and myelodysplastic Including By International Classification of Childhood Cancer(ICCC) of Childhood Classification By International SEER 21 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, San Jose-Monterey, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, SEER 21 areas (San Francisco, Connecticut, New Jersey, Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, Los Angeles, Alaska Native Registry, New York and Massachusetts). Georgia excluding ATL/RG, Idaho, International Classification of Childhood Cancer is based on ICD-O-3. Cancer. April 1, 2005: Vol 103, No. 7 , pg 1457-1467. International Classification of Childhood Cancer, Third Edition. Classifications are shown for invasive cases only except as noted. behavior, only invasive cases are shown except as noted. Includes in situ urinary bladder tumors. (19 age groups - Census P25-1130). Rates are per 1,000,000 and are age-adjusted to the 2000 US Std Population Statistic could not be calculated. XI(f) Other and unspecified carcinomas tumors XII(a) Other specified malignant tumors XII(b) Other unspecified malignant X(e) Other and unspecified malignant gonadal tumors X(e) Other and unspecified malignant XI(a) Adrenocortical carcinoma XI(b) Thyroid carcinoma XI(c) Nasopharyngeal carcinoma XI(d) Malignant melanoma XI(e) Skin carcinoma IX(d) Other specified soft tissue sarcomas IX(d) Other specified soft tissue IX(e) Unspecified soft-tissue sarcomas germ-cell tumors X(a) Intracranial and intraspinal germ cell tumors X(b) Extracranial & extragonadal tumors X(c) Malignant gonadal germ cell X(d) Gonadal carcinomas VIII(b) Chrondosarcoma and related sarcomas of bone VIII(c) Ewing tumor malignant bone tumors VIII(d) Other specified malignant bone tumors VIII(e) Unspecified IX(a) Rhabdomyosarcoma peripheral nerve & other fibrous IX(b) Fibrosarcoma, IX(c) Kaposi sarcoma VII(a) Hepatoblastoma VII(b) Hepatic carcinoma malignant hepatic tumors VII(c) Unspecified VIII(a) Osteosarcoma XII Other and unspecified malignant neoplasms XII Other and unspecified malignant XI Other malignant epithelial neoplasms and melanomas XI Other malignant epithelial neoplasms X Germ cell & trophoblastic tumors & neoplasms of gonads X Germ cell & trophoblastic tumors IX Soft tissue and other extraosseous sarcomas IX Soft tissue and VII Hepatic tumors VII Hepatic tumors VIII Malignant bone Not classified by ICCC

ICCC Group and Subgroup and Subgroup ICCC Group b c d - a

SEER Cancer Statistics Review 1975-2016 National Cancer Institute 6.9 6.2 2.7 1.9 9.3 5.3 3.1 12.6 4.6 11.6 1.8 7.5 22.3 10.2 5.1 180.2 43.8 32.8 7.9 27.2 13.0 13.9 31.3 2.9 16.1 6.0 5.6 8.9 8.6 3.0 2007-2016 2007-2016

6.6 6.0 2.3 1.7 8.5 4.7 2.8 12.5 4.6 11.0 1.8 7.0 17.1 6.1 5.9 165.1 41.6 31.3 8.1 23.5 11.4 11.6 29.4 2.5 14.5 6.2 5.6 8.7 8.5 3.2 in situ 1997-2006 1997-2006 6.8 6.4 1.6 1.2 8.8 4.9 2.8 11.0 4.8 10.8 1.6 6.7 15.2 5.2 5.3 159.2 38.2 28.7 6.9 24.4 13.4 10.3 29.9 2.6 15.7 5.7 5.1 8.5 8.2 3.2 and Year of Diagnosis Year of and

c 1987-1996 1987-1996 14.0 5.0 4.2 6.1 24.6 14.3 9.6 24.1 1.9 12.1 4.5 4.6 8.2 8.0 2.8 6.5 6.2 1.4 0.9 8.4 4.3 3.2 10.7 4.2 9.4 1.0 6.0 146.3 35.4 26.1 a 1975-1986 1975-1986 Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. For ICCC groups and subgroups that include 17.1 6.6 5.1 7.2 25.0 13.1 11.4 28.6 2.5 14.5 5.6 5.2 8.6 8.3 3.1 6.7 6.2 2.0 1.4 8.7 4.8 3.0 11.7 4.5 10.7 1.5 6.8 162.5 39.8 29.7 Selected Group and Subgroup Group Selected

b 1975-2016 1975-2016 Table 29.2 Table

d All Races, Males and Females, Ages 0-19 Males and Females, All Races, Age-Adjusted SEER Cancer Incidence Rates Incidence SEER Cancer Age-Adjusted Rate based on less than 16 cases for the time interval. Excluding benign brain and myelodysplastic syndromes myelodysplastic benign brain and Excluding By International Classification of Childhood Cancer(ICCC) of Childhood Classification By International Statistic could not be calculated. SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta). SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, (19 age groups - Census P25-1130). Rates are per 1,000,000 and are age-adjusted to the 2000 US Std Population International Classification of Childhood Cancer is based on ICD-O-3. Cancer. April 1, 2005: Vol 103, No. 7 , pg 1457-1467. International Classification of Childhood Cancer, Third Edition. Classifications are shown for invasive cases only except as noted. behavior, only invasive cases are shown except as noted. Includes in situ urinary bladder tumors. X(a) Intracranial and intraspinal germ-cell tumor X(a) Intracranial and intraspinal tumor X(c) Malignant gonadal germ cell XI(b) Thyroid carcinoma XI(d) Malignant melanoma VII(a) Hepatoblastoma VIII(a) Osteosarcoma sarcomas of bone VIII(c) Ewing tumor and related IX(a) Rhabdomyosarcoma IV(a) Neuroblastoma and ganglioneuroblastoma renal tumor VI(a) Nephroblastoma and other nonepithelial II(b,c,e) Non-Hodgkin lymphoma II(b,c,e) Non-Hodgkin and choroid plexus tumor III(a) Ependymomas III(b) Astrocytoma and intraspinal embryonal tumors III(c) Intracranial III(d) Other gliomas I(a) Lymphoid leukemia leukemia I(b) Acute myeloid II(a) Hodgkin lymphoma X Germ cell & trophoblastic tumors & neoplasms of gonads X Germ cell & trophoblastic tumors and melanomas XI Other malignant epithelial neoplasms VIII Malignant bone tumors sarcomas IX Soft tissue and other extraosseous V Retinoblastoma VI Renal tumors VII Hepatic tumors III CNS & misc intracranial & intraspinal neoplasms III CNS & misc intracranial nervous cell tumors IV Neuroblastoma and other peripheral I Leukemia reticuloendothelial neoplasms II Lymphomas and

All ICCC Groups Combined All ICCC ICCC Group and Subgroup and Subgroup ICCC Group - a b c d

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

# # # @ @ # # # # @ 0.1 -0.1 - - 0.7 0.8 0.6 0.2 0.0 0.5 - 0.3 2.8* 4.6* -1.0 0.8* 0.7* 0.6* 0.1 0.9* 0.1 1.9* 0.4 1.3* 0.8 -0.7 0.0 0.3 0.3 -0.2 APC 1996-2016 1996-2016

0.7 0.5 - - 1.0* 1.7* 0.3 0.5 1.2 1.5* - 1.3* 0.9* 0.8 1.5 0.8* 0.7* 0.9* 1.1 -0.1 -0.8 0.9* 1.8* - 2.2* 2.0* 0.7 0.4 0.3 1.4 APC in situ 1975-1995 Ages 0-19 c 0.1 0.0 - - 0.3 0.6* -0.1 0.6* 0.2 0.7* - 0.7* 1.6* 2.4* 0.7* 0.7* 0.7* 0.8* 0.9* 0.2* -0.5* 1.2* 0.7* - 0.7* 0.8* 0.6* 0.3 0.3 0.2 APC 1975-2016 50.1 49.1 - - 37.3 83.9 5.6 68.7 55.9 12.4 - 15.7 121.7 193.6 50.8 42.8 63.1 86.7 31.3 -0.9 -30.0 46.6 22.8 - 32.4 137.3 -42.6 15.9 12.7 20.4 % Change 1975-2016 a

# # #

# # # # @ 3.0* - - 0.2 1.2* 0.1 2.2* 0.3 1.3* 0.5 -0.6 0.2 0.3 0.3 -0.2 0.0 -0.1 - - 1.3* 1.4 - 0.6 0.3 0.2 - - 0.6* 0.6* 0.4 APC 1996-2016 Selected Group and Subgroup Group Selected

b Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. Steliarova-Foucher E, Stiller C, 0.4 - - 1.2 -0.8* -1.7* 0.0 2.1* - 2.8* 1.8* 0.3 0.5 0.4 1.3 0.6 0.4 - - 0.9 - - 0.7 1.2 1.4 - - 0.8* 0.7* 0.9* APC For ICCC groups and subgroups that include 1975-1995 Ages 0-14 1.7* - - 1.0* 0.3* -0.6* 1.0* 0.8* - 0.9* 0.7* 0.5 0.3 0.4 0.2 0.0 0.0 - - 0.4 - - 0.6* 0.3 0.9* - - 0.6* 0.7* 0.7* APC 1975-2016 Table 29.3 Table 85.4 60.8 - 44.1 -2.4 -36.0 23.5 35.5 - 48.7 139.3 -35.0 16.2 12.8 20.4 51.3 49.1 - - 84.4 - 36.2 41.5 54.1 46.3 - 11.4 44.2 62.0 79.9 All Races, Males and Females and Races, Males All % Change 1975-2016

d Trend based on less than 10 cases for at least one year within the time interval. Trend based on less than 10 cases for at least one year within the Tumors are abbreviated as tum. Excluding benign brain and myelodysplastic syndromes and myelodysplastic brain benign Excluding Age-Adjusted SEER Cancer Incidence Trends, 1975-2016 Trends, Incidence SEER Cancer Age-Adjusted By International Classification of Childhood Cancer(ICCC) of Childhood Classification By International Statistic could not be calculated. Neoplasms are abbreviated as neo. SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta). SEER 9 areas (San Francisco, Connecticut, Cancer is based on ICD-O-3. International Classification of Childhood Cancer. April 1, 2005: Vol 103, No. 7 , pg 1457-1467. International Classification of Childhood Cancer, Third Edition. Classifications are shown for invasive cases only except as noted. behavior, only invasive cases are shown except as noted. Includes in situ urinary bladder tumors. The APC is significantly different from zero (p<.05) 1975-1995 (p<.05). The APC for 1996-2016 is significantly different from the APC for 1975-1995 (p<.10). The APC for 1996-2016 is significantly different from the APC for The APC is the Annual Percent Change over the time interval. The APC is the Annual Percent Change nonepithelial renal tumors nervous cell tumors X(a) Intracranial and intraspinal germ-cell tum. X(a) Intracranial and intraspinal tumors X(c) Malignant gonadal germ cell XI(b) Thyroid carcinoma XI(d) Malignant melanoma VII(a) Hepatoblastoma VIII(a) Osteosarcoma of bone VIII(c) Ewing tum. and related sarcomas IX(a) Rhabdomyosarcoma IV(a) Neuroblastoma and ganglioneuroblastoma VI(a) Nephroblastoma and other II(b,c,e) Non-Hodgkin lymphoma II(b,c,e) Non-Hodgkin and choroid plexus tumors III(a) Ependymomas III(b) Astrocytoma and intraspinal embryonal tum. III(c) Intracranial III(d) Other gliomas I(a) Lymphoid leukemia leukemia I(b) Acute myeloid II(a) Hodgkin lymphoma - a b c d * # @

XI Other malignant epithelial neo. and melanomas XI Other malignant epithelial neo. IX Soft tissue and other extraosseous sarcomas IX Soft tissue and other extraosseous & neo. of gonads X Germ cell & trophoblastic tum. VIII Malignant bone tumors VII Hepatic tumors V Retinoblastoma VI Renal tumors IV Neuroblastoma and other peripheral III CNS & misc intracranial & intraspinal neo. III CNS & misc intracranial II Lymphomas and reticuloendothelial neo. II Lymphomas and I Leukemia

ICCC Group and Subgroup ICCC Group Groups Combined All ICCC

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

@ # @ # # # -0.5 -0.5 - - 0.3 0.2 - 0.7 0.4 0.3 - 0.5 2.4* - - 0.7* 0.6 0.4 -0.4 1.4* 0.7 2.0* 0.2 - 0.4 -0.7 -0.2 0.2 0.1 - APC 1996-2016 1996-2016

1.2 1.3 - - 1.7* - - 0.8 - 1.7* - 1.1 0.9 - - 1.0* 0.6* 1.1* 0.5 -0.2 -1.1 0.9 2.2* - 2.3* - - 0.9 0.8 - APC in situ 1975-1995 Ages 0-19 c -0.1 -0.2 - - 0.5 - - 0.8* - 1.0* - 0.9* 1.4* - - 0.6* 0.7* 0.7* 1.0* 0.3* -0.5* 1.0* 0.6* - 0.5* - - 0.4 0.3 - APC 1975-2016 7.3 9.8 - - 37.4 - -15.6 94.5 98.5 68.0 - 59.5 101.1 - -1.7 42.5 50.9 76.8 18.8 1.5 -34.3 48.4 40.4 - 34.6 - -27.8 40.8 33.8 4.6 % Change 1975-2016 a

# #

# # @ @ - - - 0.0 1.6* 0.8 2.3* 0.1 - 0.3 -0.5 - 0.2 0.1 - -0.4 -0.6 - - 0.6 - - 1.2* 0.6 - - - 0.6* 0.5 0.3 APC 1996-2016 Selected Group and Subgroup Group Selected

b Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. Steliarova-Foucher E, Stiller C, - - - - -0.9 - -0.1 2.5* - 3.0* - - 0.8 0.7 - 1.4 1.4 - - 1.3 - - 0.8 - - - - 1.0* 0.8* 1.1* APC For ICCC groups and subgroups that include 1975-1995 Ages 0-14 - - - - 0.2 - 0.8* 0.7* - 0.7* - - 0.3 0.3 - -0.1 -0.2 - - 0.6 - - 0.9* - - - - 0.6* 0.7* 0.7* APC 1975-2016 Table 29.4 Table All Races, Males All 19.2 - - 35.2 -3.7 -40.4 17.1 65.9 - 57.8 - -5.3 42.3 35.0 4.6 13.2 9.8 - - 60.3 - - 72.0 106.7 62.3 - - 40.2 43.6 64.6 % Change 1975-2016

d Trend based on less than 10 cases for at least one year within the time interval. Trend based on less than 10 cases for at least one year within the Tumors are abbreviated as tum. Excluding benign brain and myelodysplastic syndromes and myelodysplastic brain benign Excluding Age-Adjusted SEER Cancer Incidence Trends, 1975-2016 Trends, Incidence SEER Cancer Age-Adjusted By International Classification of Childhood Cancer(ICCC) of Childhood Classification By International Statistic could not be calculated. Neoplasms are abbreviated as neo. SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta). SEER 9 areas (San Francisco, Connecticut, Cancer is based on ICD-O-3. International Classification of Childhood Cancer. April 1, 2005: Vol 103, No. 7 , pg 1457-1467. International Classification of Childhood Cancer, Third Edition. Classifications are shown for invasive cases only except as noted. behavior, only invasive cases are shown except as noted. Includes in situ urinary bladder tumors. The APC is significantly different from zero (p<.05) 1975-1995 (p<.05). The APC for 1996-2016 is significantly different from the APC for 1975-1995 (p<.10). The APC for 1996-2016 is significantly different from the APC for The APC is the Annual Percent Change over the time interval. The APC is the Annual Percent Change nonepithelial renal tumors nervous cell tumors X(a) Intracranial and intraspinal germ-cell tum. X(a) Intracranial and intraspinal tum. (testis) X(c) Malignant gonadal germ cell XI(b) Thyroid carcinoma XI(d) Malignant melanoma VII(a) Hepatoblastoma VIII(a) Osteosarcoma of bone VIII(c) Ewing tum. and related sarcomas IX(a) Rhabdomyosarcoma IV(a) Neuroblastoma and ganglioneuroblastoma VI(a) Nephroblastoma and other II(b,c,e) Non-Hodgkin lymphoma II(b,c,e) Non-Hodgkin and choroid plexus tumors III(a) Ependymomas III(b) Astrocytoma and intraspinal embryonal tum. III(c) Intracranial III(d) Other gliomas I(a) Lymphoid leukemia leukemia I(b) Acute myeloid II(a) Hodgkin lymphoma - a b c d * # @

ICCC Group and Subgroup ICCC Group Groups Combined All ICCC

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

# # 0.6 0.3 - - 1.2* 1.9* - -0.5 - 0.7 - -0.2 3.0* 4.6* -1.0 0.9* 0.9* 0.8* 0.7 0.2 -0.5 1.5 0.7 - 1.2 -0.6 - 0.2 0.2 - APC 1996-2016 1996-2016

0.3 -0.2 - - 0.1 0.6 - 0.2 - 1.2 - - 0.8 1.4 - 0.7* 0.9 0.8 1.8* 0.1 -0.4 1.0 1.3* - 2.1* - - -0.2 -0.3 - APC in situ 1975-1995 Ages 0-19 c 0.3 0.1 - - -0.1 0.4 - 0.4 - 0.2 - - 1.6* 2.5* - 0.7* 0.8* 0.8* 0.8* 0.1 -0.6* 1.6* 0.8* - 1.0* - - 0.3 0.3 - APC 1975-2016 101.0 88.9 - - 37.0 46.0 - 39.4 5.0 -33.7 - -33.1 134.3 188.2 108.8 43.3 81.9 101.0 47.7 -4.5 -24.8 42.8 4.0 - 29.7 - -58.2 -6.1 -6.1 - % Change 1975-2016 a

2.9* - - 0.4 0.6 - - 0.5 - 0.8 - - 0.2 0.2 - 0.4 0.4 ------0.3 - 1.4 - - 0.7* 0.7* 0.6 APC 1996-2016 Selected Group and Subgroup Group Selected

b Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. Steliarova-Foucher E, Stiller C, - - - 1.2 -1.0 - - 1.5* - 2.6* - - 0.0 -0.1 - -0.2 -0.4 - - 0.7 - - 0.5 - - - - 0.6* 0.7 0.7 APC For ICCC groups and subgroups that include 1975-1995 Ages 0-14 - - - 0.6* 0.4 - - 0.8* - 1.1* - - 0.3 0.3 - 0.2 0.1 - - - - - 0.4 - - - - 0.7* 0.7* 0.7* APC 1975-2016 Table 29.5 Table All Races, Females All 135.1 - - 55.4 0.0 -30.5 42.0 7.3 - 40.1 - - -6.1 -6.1 - 94.8 88.9 - - 118.8 - - 7.4 - 30.2 - - 49.3 91.1 102.2 % Change 1975-2016

d Trend based on less than 10 cases for at least one year within the time interval. Trend based on less than 10 cases for at least one year within the Tumors are abbreviated as tum. Excluding benign brain and myelodysplastic syndromes and myelodysplastic brain benign Excluding Age-Adjusted SEER Cancer Incidence Trends, 1975-2016 Trends, Incidence SEER Cancer Age-Adjusted By International Classification of Childhood Cancer(ICCC) of Childhood Classification By International Statistic could not be calculated. Neoplasms are abbreviated as neo. SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta). SEER 9 areas (San Francisco, Connecticut, Cancer is based on ICD-O-3. International Classification of Childhood Cancer. April 1, 2005: Vol 103, No. 7 , pg 1457-1467. International Classification of Childhood Cancer, Third Edition. Classifications are shown for invasive cases only except as noted. behavior, only invasive cases are shown except as noted. Includes in situ urinary bladder tumors. The APC is significantly different from zero (p<.05) 1975-1995 (p<.05). The APC for 1996-2016 is significantly different from the APC for 1975-1995 (p<.10). The APC for 1996-2016 is significantly different from the APC for The APC is the Annual Percent Change over the time interval. The APC is the Annual Percent Change nonepithelial renal tumors nervous cell tumors X(a) Intracranial and intraspinal germ-cell tum. X(a) Intracranial and intraspinal tum. (ovary) X(c) Malignant gonadal germ cell XI(b) Thyroid carcinoma XI(d) Malignant melanoma VII(a) Hepatoblastoma VIII(a) Osteosarcoma of bone VIII(c) Ewing tum. and related sarcomas IX(a) Rhabdomyosarcoma IV(a) Neuroblastoma and ganglioneuroblastoma VI(a) Nephroblastoma and other II(b,c,e) Non-Hodgkin lymphoma II(b,c,e) Non-Hodgkin and choroid plexus tumors III(a) Ependymomas III(b) Astrocytoma and intraspinal embryonal tum. III(c) Intracranial III(d) Other gliomas I(a) Lymphoid leukemia leukemia I(b) Acute myeloid II(a) Hodgkin lymphoma - a b c d * # @

ICCC Group and Subgroup ICCC Group Groups Combined All ICCC

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

79.0 82.5 73.2 69.0 76.3 75.7 70.5 90.5 90.3 98.0 92.6 99.8 94.7 83.7 86.5 90.7 65.9 93.5 98.4 90.8 73.5 80.0 82.8 64.6 53.9 81.4 81.2 95.7 92.1 92.6 0-14

d d d 44.0 - 68.0 66.6 57.5 68.6 44.9 93.0 92.5 96.0 93.6 99.4 94.5 85.0 72.8 74.1 66.3 93.5 96.7 88.3 76.8 90.5 75.4 67.5 83.8 56.8 - - 75.0 - 15-19

d d 64.1 - 72.0 67.6 74.1 74.4 55.8 91.1 90.0 97.1 92.9 99.7 95.5 83.0 78.6 83.5 58.3 93.7 98.2 89.9 79.1 81.6 81.7 76.4 72.3 91.6 92.2 - 91.7 96.6 10-14 behavior,

d d d 68.4 - 74.5 71.7 74.9 78.8 79.4 99.2 100.0 100.0 92.7 100.0 95.4 83.6 90.2 92.7 70.6 95.3 99.4 93.7 70.0 79.7 77.3 77.8 41.3 78.7 78.0 - 90.2 91.5 5-9 and Sex and Age and Sex

c in situ

d d d 79.6 79.4 79.2 - 91.5 78.0 73.7 90.3 - 100.0 90.0 - 88.1 85.8 91.3 94.4 70.7 88.2 94.9 86.9 75.4 79.2 90.4 58.0 53.3 76.2 76.1 95.0 93.7 93.8 Both Sexes by Age Both Sexes 1-4

d d d 63.9 - - - 58.9 80.7 81.5 26.1 - 90.5 90.5 96.9 87.6 87.5 87.3 87.1 - - - 66.8 71.5 83.2 - 95.4 - - - 77.7 60.1 55.9 <1 a

66.7 93.1 97.1 87.6 75.1 82.3 82.5 67.8 56.1 82.3 82.4 95.9 93.7 94.0 77.4 85.6 72.3 71.2 67.7 76.3 65.1 90.9 91.1 96.6 94.8 99.4 95.5 85.3 84.7 89.4 Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. Steliarova-Foucher E, Stiller C, Female Selected Group and Subgroup Selected

b 65.4 93.7 97.3 90.9 73.2 81.2 80.0 63.0 63.4 79.0 78.8 95.5 87.4 90.5 74.0 80.2 70.3 65.5 71.6 70.5 65.6 92.9 91.2 96.3 89.9 99.7 92.9 83.0 83.7 87.8 Male 66.0 93.5 97.3 89.8 74.1 81.8 81.2 64.9 59.8 80.6 80.5 95.7 90.7 92.4 75.3 82.2 71.1 68.0 69.9 73.2 65.3 92.2 91.2 96.4 93.3 99.5 94.4 84.1 84.1 88.5 Ages 0-19 by Sex Ages 0-19 Table 29.6 Table Total For ICCC groups and subgroups that include are derived from life tables by socio-economic status, geography and race are derived from life tables by socio-economic

f 5-Year Relative Survival (Percent), 2009-2015 (Percent), Survival Relative 5-Year Excluding benign brain and myelodysplastic syndromes myelodysplastic benign brain and Excluding

Expected survival rates By International Classification of Childhood Cancer(ICCC) of Childhood Classification By International International Classification of Childhood Cancer is based on ICD-O-3. International Classification of Childhood No. 7 , pg 1457-1467. Cancer, Third Edition. Cancer. April 1, 2005: Vol 103, International Classification of Childhood Classifications are shown for invasive cases only. only invasive cases are shown except as noted. The standard error is between 5 and 10 percentage points. The standard error is greater than 10 percentage points. Includes in situ urinary bladder tumors. the time period. Statistic could not be calculated due to fewer than 25 cases during Neoplasms are abbreviated as neo. SEER 18 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, San Jose-Monterey, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, SEER 18 areas (San Francisco, Connecticut, New Jersey and Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, Los Angeles, Alaska Native Registry, Georgia excluding ATL/RG). developed by the SEER program. 2016. Based on follow-up of patients into XI(b) Thyroid carcinoma XI(d) Malignant melanoma VIII(a) Osteosarcoma sarcomas of bone VIII(c) Ewing tumor and related IX(a) Rhabdomyosarcoma germ-cell tumor X(a) Intracranial and intraspinal tumor X(c) Malignant gonadal germ cell VI(a) Nephroblastoma and other nonepithelial renal tumor VI(a) Nephroblastoma and other nonepithelial VII(a) Hepatoblastoma III(a) Ependymomas and choroid plexus tumor III(a) Ependymomas III(b) Astrocytoma and intraspinal embryonal tumors III(c) Intracranial III(d) Other gliomas IV(a) Neuroblastoma and ganglioneuroblastoma I(a) Lymphoid leukemia leukemia I(b) Acute myeloid II(a) Hodgkin lymphoma lymphoma II(b,c,e) Non-Hodgkin XI Other malignant epithelial neo. and melanomas XI Other malignant epithelial neo. IX Soft tissue and other extraosseous sarcomas IX Soft tissue and other extraosseous & neo. of gonads X Germ cell & trophoblastic tumors V Retinoblastoma VI Renal tumors VII Hepatic tumors VIII Malignant bone tumors III CNS & misc intracranial & intraspinal neo. III CNS & misc intracranial tumors and other peripheral nervous cell IV Neuroblastoma I Leukemia reticuloendothelial neo. II Lymphomas and b c d e f - a

All ICCC Groups Combined All ICCC ICCC Group & Subgroup ICCC Group

SEER Cancer Statistics Review 1975-2016 National Cancer Institute Figure 29.1

Childhood Cancer : SEER Incidence Rates 2012-2016 by ICCC Group (includes myelodysplastic syndromes and Group III benign brain) Under 20 Years of Age, Both Sexes, All Races

ICCC group

Leukemias - I 49.5

Lymphomas - II 26.6

a Brain/CNS - III 52.4

Neuroblastoma - IV 8.6

Retinoblastoma - V 3.3

Renal - VI 7.1

Hepatic - VII 2.7

Bone - VIII 9.8

Soft tissue - IX 12.7

Germ cell - X 12.2

Other malig. epithelial neo. - XI 23.5

Other - XII 0.7

0 10 20 30 40 50 60 Rate per 1,000,000

Source: SEER 21 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, San Jose-Monterey, Los Angeles, Alaska Native Registry,Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, New Jersey, Georgia excluding ATL/RG, Idaho, New York and Massachusetts). Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). International Classification of Childhood Cancer is based on ICD-O-3. Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. International Classification of Childhood Cancer, Third Edition. Cancer. April 1, 2005: Vol 103, No. 7 , pg 1457-1467. a Rate for Group III (Brain/CNS) includes benign brain tumors. SEER Cancer Statistics Review 1975-2016 National Cancer Institute Figure 29.2 Childhood Cancer: SEER Incidence Rates 2012- 2016 by ICCC Group and Race/Ethnicity (includes myelodysplastic syndromes and Group III benign brain) Both Sexes, Under 20 Years of Age Rate per 1,000,000 220 I - Leukemia II - Lymphoma 200 III - Brain/CNS a Other 180 84.9

160 73.2 140 61.1 65.8 120 43.7 100 55.0 39.6 36.3 80 43.2 35.7 20.9 27.4 60 21.8

40 24.0 13.2 52.4 60.6 20 36.2 46.7 31.0

0 White Black American Indian/ Asian or Pacific Hispanic c Alaska Native b Islander Race/Ethnicity Source: SEER 21 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, San Jose-Monterey, Los Angeles, Alaska Native Registry, Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, New Jersey, Georgia excluding ATL/RG, Idaho, New York and Massachusetts). Incidence rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). International Classification of Childhood Cancer is based on ICD-O-3. Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. International Classification of Childhood Cancer, Third Edition. Cancer. April 1, 2005: Vol 103, No. 7 , pg 1457-1467. a Rate for Group III (Brain/CNS) includes benign brain tumors. b Incidence rates for American Indian/Alaska Native are based on the CHSDA(Contract Health Service Delivery Area) counties. c Hispanic is not mutually exclusive from whites, blacks, Asian/Pacific Islanders, and American Indians/Alaska Natives. Incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry.

SEER Cancer Statistics Review 1975-2016 National Cancer Institute Figure 29.3

Childhood Cancer 5-Year Observed Survival (%) by ICCC Group a and Race/Ethnicity Both Sexes, Under 20 Years of Age, 2009-2015 5-Year Observed Survival 100

White Black AI/AN b Asian/Pacific Islander Hispanicc

0 Lymphoid Other Leukemia Lymphoma Brain/CNS Other Leukemias ICCC Site Source: SEER 18 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, San Jose-Monterey, Los Angeles, Alaska Native Registry, Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, New Jersey and Georgia excluding ATL/RG). International Classification of Childhood Cancer is based on ICD-O-3. Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. International Classification of Childhood Cancer, Third Edition. Cancer. April 1, 2005: Vol 103, No. 7, pg 1457-1467. a Excludes myelodysplastic sydromes (MDS) and benign brain tumors. b American Indian/Alaska Native. Survival data for American Indian/Alaska Native are based on the CHSDA (Contract Health Service Delivery Area) counties. c Hispanic is not mutually exclusive from whites, blacks, Asian/Pacific Islanders, and American Indians/Alaska Natives. Survival data for Hispanics are based on NHIA and excludes cases from the Alaska Native Registry.

SEER Cancer Statistics Review 1975-2016 National Cancer Institute