Program Book

2010 Meeting Organizers Fred Winston Harvard Medical School Scott Hawley Stowers Institute for Medical Research

2010 Genetics Society of America Board of Directors Officers President Scott Hawley Stowers Institute for Medical Research Vice President Paul W. Sternberg California Institute of Technology Past President Fred Winston Harvard Medical School Secretary Mariana Wolfner Cornell University Treasurer Trudy F. Mackay North Carolina State University Journal Editor Mark Johnston University of Colorado

Directors Utpal Banarjee University of California, Los Angeles Douglas Koshland University of California, Berkeley Sally Camper University of Michigan Medical School Charles Langley University of California, Davis Elizabeth De Stasio Lawrence University Susan Lovett Brandeis University Jay Dunlap Dartmouth Medical School Thomas Silhavy Princeton University Sue Jinks-Robertson Duke University Medical Center Susan Wessler University of Georgia

Sherry Marts, Executive Director The Genetics Society of America 9650 Rockville Pike, Bethesda, MD 20814-3998 telephone: (301) 634-7300 • fax: (301) 634-7079 e-mail: [email protected] • Web site: www.genetics-gsa.org

The Genetics 2010: Model Organisms to Human Biology meeting gratefully acknowledges the following companies and funding agencies for their generous contributions in support of the meeting. Agilent Technologies Annual Reviews BGI-Shenzhen BIOBASE Burroughs Wellcome Cold Spring Harbor Laboratory Press FASEB Genetic Services Inc. The Company of Biologists LifeTech Helicos BioSciences Corporation Illumina Life Technologies National Institutes of Health National Institute of Neurological Disorders and Stroke (NINDS) National Human Genome Research Institute (NHGRI) Roche Sunrise Science W. H. Freeman

Table of Contents

Letter of Welcome ...... 4

Schedule of Events ...... 5

Map: Sheraton Boston ...... 8

Map: Poster/Exhibit Sessions ...... 9

General Information ...... 10

Sponsors and Exhibits ...... 12

Workshops ...... 14

Platform Session Listings ...... 17

Poster Session Listings ...... 23

Speaker and Author Index ...... 37

Company Sponsor Ads ...... 43

June 12, 2010

Dear Meeting Participant,

Welcome to The Genetics Society of America (GSA) meeting, “Genetics 2010: Model Organisms to Human Biology”! The Genetics Society of America believes that, in this age, it is important to convene a meeting that addresses the value of model organisms for understanding diverse aspects of human biology. This is the third biannual meeting in this area that brings together investigators who study model organisms with investigators who study human biology and disease. Our hope is that this meeting will provide a dynamic forum for the exchange of results and ideas between scientists who do not normally interact.

By organizing this meeting, the GSA stresses our advocacy for genetic research in model organisms and we particularly appreciate the support from the National Institutes of Health. This broad meeting is action packed with a stellar array of speakers and posters. We look forward to exciting discussions over the next few days.

We hope that you return to your labs after this meeting invigorated with the promise of genetic analysis for understanding biology. We, on the GSA Board of Directors, are working to enhance the role of the GSA in the genetics research community. If you are currently a member of GSA we appreciate your support, and we welcome your input and ideas. If you are not yet a member of GSA, please join us in our efforts to discover the genetic mechanisms that underlie the Earth’s biological diversity.

Sincerely,

Fred Winston Scott Hawley Meeting Chair, GSA Past President Meeting Co-chair, GSA President

4 Schedule of Events

SATURDAY, JUNE 12

1:00 pm - 4:00 pm Education and Outreach Workshop Constitution Organizers: Beth De Stasio, Lawrence University; and Pat Pukkila, Ballroom B University of NC, Chapel Hill 2:00 pm - 5:00 pm High-Throughput RNAi Screening in Model Systems Used Constitution to Study Human Biology at Genome Scale Ballroom A Organizers: Stephanie Mohr, Harvard Medical School and Dana Farber/Harvard Cancer Center; and Liz Perkins, Massachusetts General Hospital and Harvard Medical School 5:00 pm - 10:00 pm Registration Constitution Foyer 6:45 pm - 7:00 pm Welcome and Opening Remarks Grand Ballroom Fred Winston, Meeting Chair and GSA Past President Scott Hawley, Meeting Co-chair and GSA President Sherry Marts, GSA Executive Director 7:00 pm - 9:00 pm Personal Genomics Grand Ballroom Chairs: Chuck Langley, University of CA, Davis; and David Altshuler, Harvard Medical School and Massachusetts General Hospital 9:15 pm - 10:00 pm Keynote Address Grand Ballroom

Carol Greider, Johns Hopkins Medical School Modeling connections: telomeres and human disease 10:00 pm - 11:30 pm Opening Mixer Constitution

Ballroom

5 Schedule of Events

SUNDAY, JUNE 13 7:30 am - 5:30 pm Registration Constitution Foyer 7:30 am - 8:30 am Continental Breakfast Independence

Ballroom 8:15 am - 8:30 am Genetics Society of America Award Presentations Grand Ballroom Edward Novitski Prize presented by Scott Hawley to Tom Cline, University of California, Berkeley

GSA Medal presented by Fred Winston to Barbara Meyer, University of California, Berkeley 8:30 am - 10:30 am Sex and Gene Expression Grand Ballroom Chairs: Barbara Meyer, University of CA, Berkeley; and Melissa Hines, University of Cambridge 10:30 am - 11:00 am Coffee break Grand Ballroom

Sponsored by Genetic Services Inc. 11:00 am - 1:00 pm Models of Disease Grand Ballroom Chairs: Susan Lindquist, Whitehead Institute and Massachusetts Institute of Technology; and Rick Lifton, Yale University School of Medicine 1:15 pm - 3:15 pm Career Luncheon Independence

Mentor tables will be available for students and postdocs Ballroom 3:30 pm - 5:30 pm Cancer as a Genetic Disease Grand Ballroom Chairs: Angelika Amon, Massachusetts Institute of Technology; and Phil Beachy, Stanford University School of Medicine 7:15 pm - 7:30 pm Genetics Society of America Award Presentation Grand Ballroom Thomas Hunt Morgan Medal presented by Jim Haber to Alexander Tzagoloff, Columbia University 7:30 pm - 8:15 pm Keynote Address Grand Ballroom Gary Ruvkun, Harvard Medical School and Massachusetts General Hospital C. elegans poison detection pathways 8:15 pm - 11:15 pm Poster Session 1 and Exhibits Back Bay A/B/C 8:15 pm - 9:45 pm: Even-numbered "A" Poster Authors 9:45 pm - 11:15 pm: Odd-numbered "A" Poster Authors

6 Schedule of Events

MONDAY, JUNE 14 7:30 am - 8:30 am Continental Breakfast Independence

Ballroom 8:00 am - 5:30 pm Registration Constitution Foyer 8:30 am - 10:30 am Neurogenetics: from Synapses to Senescence Grand Ballroom Chairs: Barry Ganetzky, University of WI, Madison; and Pamela Sklar, Harvard Medical School and Massachusetts General Hospital 10:30 am - 11:00 am Coffeebreak Grand Ballroom 11:00 am - 1:00 pm Modern Approaches to Pathogenesis and Infectious Grand Ballroom Disease Chairs: Gerry Fink, Whitehead Institute and Massachusetts Institute of Technology; and Joe DeRisi, University of CA, San Francisco 1:15 pm - 3:15 pm Advanced DNA Sequencing Lunch and Workshop Independence

Sponsored by Helicos, Illumina, Life Technologies and Roche Ballroom 3:30 pm - 5:30 pm Stem Cell: the Genetics of Commitment Grand Ballroom Chairs: Margaret Fuller, Stanford University; and George Daley, Harvard Medical School and Children's Hospital 5:30 pm - 6:30 pm GSA Education Special Interest Group Social Berkeley Room

Sponsored by W. H. Freeman Publishers 7:30 pm - 8:15 pm Keynote Address Grand Ballroom Jeremy Berg, National Institute of General Medical Sciences Common Pathways and Individual Differences: From Model Organisms to Medicine 8:15 pm - 11:15 pm Poster Session 2 and Exhibits Back Bay A/B/C 8:15 pm - 9:45 pm: Even-numbered "B" Poster Authors 9:45 pm - 11:15 pm: Odd-numbered "B" Poster Authors TUESDAY, JUNE 15 7:30 am - 8:30 am Continental Breakfast Independence

Ballroom 8:30 am - 10:30 am Organismal Architecture and Developmental Grand Ballroom Disabilities Chairs: Olivier Pourquie, Stowers Institute for Medical Research; and Matt Warman, Harvard Medical School and Children's Hospital 10:30 am - 11:00 am Coffeebreak Grand Ballroom 11:00 am - 1:00 pm Analyzing Genomes Grand Ballroom Chairs: Barbara Wold, CalTech; and Joe Ecker, The Salk Institute

9 General Information

2010 Genetics Society of America Awards Each year The Genetics Society of America (GSA) gives several awards for scientific achievement and contributions to the community of geneticists. The following awards for 2010 will be presented at the meeting:

Sunday, June 13, 8:15 am – 8:30 am, Grand Ballroom The 2010 Edward Novitski Prize will be presented to Tom Cline by Scott Hawley. The Edward Novitski Prize is designed to recognize an extraordinary level of creativity and intellectual ingenuity in solving significant problems in genetics research.

The GSA Medal will be presented to Barbara Meyer by Fred Winston. The Genetics Society of America (GSA) Medal is for outstanding contributions to the field of genetics in the last 15 years.

Sunday, June 13, 7:15 pm – 7:30 pm, Grand Ballroom The Thomas Hunt Morgan Medal will be presented to Alexander Tzagoloff by Jim Haber. The Morgan Medal is for lifetime contributions in the field of genetics.

Registration and Information Desk The Conference registration desk will be open according to the following schedule:

Saturday, June 12 5:00 pm–10:00 pm Constitution Foyer Sunday, June 13 7:30 am–5:30 pm Constitution Foyer Monday, June 14 8:00 am–5:30 pm Constitution Foyer

Instructions for Speakers Please arrive 60 minutes before the beginning of your session with your CD, or memory stick to load your presentation on the MAC meeting computer. If you plan to show Quicktime movies, please DO NOT attach them to your presentation. You should include them as separate files on the disk and be prepared to place them back into your presentation after loading on the meeting computer.

Poster Sessions All posters will be displayed in Back Bay A/B/C. Presenters may mount posters beginning at 12:00 noon on Sunday, June 13. All posters will be up for the entire conference. Authors will present their poster, according to the following schedule:

Sunday, June 13 Poster Session 1 All even numbered “A” posters 8:15 pm – 9:45 pm All odd numbered “A” posters 9:45 pm – 11:15 pm

Monday, June 14 Poster Session 2 All even numbered “B” posters 8:15 pm – 9:45 pm All odd numbered “B” posters 9:45 pm – 11:15 pm

All presenters should remove their posters by 11:15 pm on Monday, June 14. After that time, remaining posters will be removed and may be lost or thrown away. The meeting does not take responsibility for posters that are not removed on time.

Employment Opportunities/Seeking Employment Notices Individuals and institutions offering or seeking employment may post notices and resumes on the “Employment Opportunities” bulletin board set up near the conference registration desk in the Constitution Ballroom foyer.

10 General Information

Social Events Opening Mixer: Meet friends and colleagues at the Opening Mixer on Saturday, June 12, in the Constitution Ballroom immediately following the evening session. Complimentary beer, wine and sodas will be available.

GSA Careers Luncheon: The GSA Careers Luncheon, on Sunday, June 13,(originally the GSA Mentoring Luncheon) is an excellent opportunity for undergraduates, graduate students, and postdoctoral fellows to have informal conversations with senior career scientists regarding the unique challenges and rewards of a scientific career. The luncheon is organized by topic table. Topics may include things like: transition to independence, work-family balance, teaching at undergraduate institutions, non-academic careers for scientists, the when, how, and why of networking, dealing with difficult colleagues, etc. The senior career scientists include invited speakers at the conference, GSA volunteer leaders, the GSA Executive Director, and others.

Interested students and postdocs should look for the designated tables at the luncheon in the Independence Ballroom. Please Note: This luncheon is included in the conference registration fee and is open to all registrants.

Advanced DNA Sequencing Workshop and Lunch: All meeting registrants are invited to this luncheon meeting on Monday, June 14 from 1:15 pm until 3:15 pm in Independence Ballroom. New commercial systems for high throughput DNA sequencing will be described. There will be opportunity for questions and discussion. This workshop is sponsored by Helicos, Illumina, Life Technologies and Roche.

Evening Socials: Complimentary beer, wine and sodas will be available in the Back Bay A/B/C during the poster sessions.

Meals Please note that a continental breakfast is available on Sunday, Monday and Tuesday for all meeting participants. Lunch will be provided on Sunday and Monday. All other meals are not included in your meeting registration.

All meals will be served in the Independence Ballroom according to the following schedule: Sunday, June 13 Monday, June 14 Tuesday, June 15 Breakfast 7:30 am – 8:30 am 7:30 am–8:30 am 7:30 am–8:30 am Lunch 1:15 pm – 3:15 pm 1:15 pm–3:15 pm

Internet Access The Sheraton Boston provides wireless internet access in the main lobby.

Smoking Smoking is allowed only in designated outdoor areas.

11 Sponsors and Exhibits

As sponsors and exhibitors at the Genetics 2010: Model Organisms to Human Biology meeting, the following companies have contributed to the support of this meeting. Registrants are encouraged to visit the exhibits in Back Bay A/B/C to take advantage of this opportunity to see the new products, publications and services available from these companies.

Agilent Technologies The Company of Biologists 2850 Centerville Road Bidder Building Wilmington, DE 19808 140 Cowley Road Phone: 800-227-9770 Cambridge, CB4 ODL UK Email: [email protected] Phone: 44-1223-433319 URL: www.agilent.com/chem E-mail: [email protected] URL: www.biologists.org Agilent is a leading supplier of life science instrumentation. LC, GS and mass specs, DNA The Company of Biologists is the not-for-profit publisher microarrays and scanners, thermal cyclers, automation of the internationally renowned journals Development, instruments, reagents and software products are used Journal of Cell Science and The Journal of Experimental globally. Agilent has developed products and services Biology. In August 2008, The Company launched Disease utilized along the entire discovery value chain, from basic Models & Mechanisms (DMM), a journal publishing biological research through drug discovery and research using model organisms to understand the manufacturing. mechanisms underlying human disease and to develop novel diagnostics and therapeutics. BIOBASE 100 Cummings Center FASEB Suite 107A 9650 Rockville Pike Beverly, MA 01915 Bethesda, MD 20814 Phone: 978-544-8270 Phone: 301-634-7930 E-mail: [email protected] E-mail: [email protected] URL: www.biobase-international.com URL: www.faseb.org/marc/

BIOBASE is a leading provider of biological databases and FASEB MARC Program provides a variety of activities to analysis tools. The BIOBASE Knowledge Library™ (BKL) support the training of minority students, includes BKL PROTEOME for disease and yeast research, postdoctorates, faculty and scientists in the biomedical BKL TRANSFAC®, for gene regulation research, the and behavioral sciences. We offer travel awards for ExPlain analysis system, and the Human Gene Mutation scientific meetings, research conferences, and student Database®, (HGMD) for inherited disease mutation data. summer research opportunities programs. We also sponsor Career Development Programs including grantsmanship training seminars.

12 Sponsors and Exhibits Science in the News (SITN) Genetic Services Inc. c/o Marshall Thomas 16 Craig Road 260 Warren Alpert Building Sudbury, MA 01776 200 Longwood Avenue Phone: 617-872-3135 Boston, MA 02115 E-mail: [email protected] Email: [email protected] URL: www.geneticservices.com URL: sitn.hms.harvard.edu

Genetic Services Inc. offers a variety of services for the Science in the News (SITN) is a graduate student Drosophila and Model Research Community including organization at Harvard University whose mission is to injections, P-element and site directed transgenic bring the newest science to a general audience. At SITN, production, genetic screening, ZFN injections, mosquito we strive to share our enthusiasm for science without injections, stock maintenance and more. Let us help over-hyping the promise of new discoveries. Graduate speed up your research and make your lab more students in SITN present a 9-week lecture series geared competitive! towards the general public in the fall, and we publish a twice-monthly newsletter that delves into new SPONSOR OF THE COFFEEBREAK discoveries and emerging trends in science. The SITN ON SUNDAY, JUNE 13 AT 10:30 AM model benefits graduate students with a unique opportunity to work on their science communication Life Technologies skills, while the public benefit from cutting-edge science 5791 Van Allen Away programs. Carlsbad, CA 92008 Email: [email protected] Sunrise Science URL: www.lifetechnologies.com 7940 Silverton Avenue #106 Life Technologies is a global biotechnology tools San Diego, CA 92126 company dedicated to improving the human condition. Phone: 760-889-0982 Our technologies enable researchers to accelerate E-mail: [email protected] scientific exploration, driving discoveries that make life URL: www.sunrisescience.com better. Our customers work across the biological spectrum, advancing personalized medicine, Sunrise Science Products manufactures hundreds of regenerative science, molecular diagnostics, agricultural selective and non-selective yeast media formulations, & environmental research, and 21st century forensics. and custom recipes are quickly produced. Plating tools complement our media and protein expression product groups, and we are proud to offer unique PickPen® magnetic tools for efficient isolation of DNA, RNA and proteins.

13 Workshops

Saturday, June 12 1:00 PM–4:00 PM Education and Outreach Workshop

Room: Constitution Ballroom B Organizers: Beth De Stasio, Lawrence University, and Pat Pukkila, University of NC, Chapel Hill Speakers:

1:00 pm Using text messaging to encourage analytical thinking and discussion in large genetics classes. Pukkila Patricia. University of North Carolina at Chapel Hill.

The benefits of incorporating conclusions from discipline-based educational research (DBER) to improve student learning have been carefully documented (reviewed in Wood, 2009) but barriers to widespread implementation of even incremental changes remain. The problems are particularly apparent in introductory genetics courses when student learning objectives do not lend themselves well to multiple-choice questions (which are the basis of active learning strategies utilizing "clickers"). In addition, faculty often are reluctant to require students to purchase a clicker and incur the extra expense for their courses. To harness the power of real-time classroom assessment, I asked students to respond to questions posed in class using text messaging in my Fall, 2009 Genetics course. The messages were captured for immediate display (and subsequent downloading) using Poll Everywhere (www.polleverywhere.com). Student learning objectives included interpreting genetic information as the product of research, deciding what information is needed to draw a conclusion and placing limits on those conclusions, understanding the relevance of model organisms, and applying conceptual understanding of genomes, genes, chromosomes, loci, and chromosome aberrations to new situations. Student assessment was overwhelmingly positive (82% thought Poll Everywhere should continue to be used in the course). Students reported that their understanding of course material was aided by formulating a written response to the questions (70%) and by seeing classmates' responses (67%). Student preparation prior to class was substantial (74% "frequently" or "always" completed the advance assignments), and 65% said that the text messaging "made me more likely to want to participate in the class discussion". Other faculty experimenting with the system also appreciate that students can use the technology they already own (cell phones or laptops in classrooms with WiFi access). Consequently, some faculty feel free to make incremental changes in their courses by conducting polls only on occasion. The system is currently being used in 5 additional Biology courses (Introductory Biology, Ecology and Evolution, Anatomy and Physiology, and two additional sections of Genetics and Molecular Biology). Their experiences will be invaluable as we continue to refine student learning goals and assessment methods across our curriculum. Wood, WB Annu. Rev. Cell Dev. Biol 2009 25: 5.1-5.20.

1:30 pm Coupling intensive analysis of primary literature with email interviews of authors demystifies data interpretation while humanizing research and researchers: the CREATE approach. Sally Hoskins. City College of CUNY, New York.

For many students, the gap between science as portrayed in textbooks and the actual language of science-journal articles-- is uncomfortably wide. In addition, the creative and open-ended nature of scientific research is under-emphasized in typical textbooks. The C.R.E.A.T.E. (Consider, Read, Elucidate hypotheses, Analyze and interpret the data, and Think of the next Experiment) method (Hoskins et al, Genetics 176: 1381-1389, 2007) complements standard approaches to science teaching, using in-depth analysis of journal articles to demystify the process of reading scientific literature, while simultaneously humanizing the research process by getting students' own questions for authors answered through an email survey. CREATE modules comprise series of 4-5 papers published sequentially from single labs, following the development and evolution of a single research project. Using a novel combination of pedagogical tools, including concept mapping, diagrammatic representation of methods, and annotation of figures, students dissect each paper into its component experiments, reconstruct these, and then analyze the data as if it had been generated in their own laboratories. Classroom sessions resemble lab meetings, as hypotheses are defined, controls closely examined, and interpretations debated. After completing analysis of each paper, students design "the two experiments I would do as follow-up". Experiments are vetted in class in a grant panel exercise that models genuine NSF/NIH panels. Late in the semester, students pose their own questions about "the research life," personal motivations for doing science, and the challenges and rewards of research careers, in an email survey sent to each author. The diverse and frank responses from graduate students, postdocs and PIs help to reveal research science as a creative activity open to a wide range of individuals. Assessments of CREATE students at CCNY showed significant gains in critical analytical ability, understanding of content and of the nature of science, as well as increased enthusiasm for research careers. To test CREATE in a wider range of students, 16 faculty from campuses in the NY/NJ/CT/PA area were trained in CREATE approaches in workshops at the CUNY Graduate Center. Eight subsequently adapted CREATE methods for courses on their home campuses. Students on each campus (ranging from community college to the Ivy League) were assessed using methods parallel to those used previously. Results show gains in critical thinking, understanding of the nature of science, and overall enthusiasm for science parallel to those seen at CCNY. Thus CREATE appears adaptable to multiple content areas and effective in a wide range of student cohorts. The CREATE class, a "laboratory of the mind", is a cost-effective way to introduce students to the universal languages of data evaluation and experimental design, helping them gain transferable skills that can be applied to any challenging reading and analysis they encounter in the future. I will outline the method, briefly discuss assessment data, and offer suggestions for implementing CREATE in a variety of contexts.

14 Workshops

2:00 pm Innovations in Education and Public Outreach. Roundtable discussion led by Beth DeStasio, Lawrence University.

2:30pm Break

2:40 pm Reports from Roundtable Discussion Groups.

3:00 pm Synthetic Biology and Introductory Biology Unify the Science of Biology. A. Malcolm Campbell. Davidson College, Charlotte, NC.

BIO2010 made several curriculum recommendations to improve American biomedical research capacity. One key recommendation was to increase the amount of math within biology courses, not just add math courses to the biology major. At Davidson College, we are integrating biology and math early in the undergraduate curriculum. We use synthetic biology research projects as a hands-on learning environment where biology and mathematics majors work collaboratively to design, model, build, test and revise biological devices such as bacterial computers that can solve math problems. In five years, we have attracted diverse students, tracked students who have taken more courses outside their majors, and noted many students who have changed their minds away from medical schools. Synthetic biology is relatively inexpensive and requires no special equipment (see http://www.bio.davidson.edu/people/macampbell/Pubs/CURQ_2009.pdf). With the success of synthetic biology, we have realized that our introductory biology courses were not optimized. We know three things about how people learn best: 1) they should construct their own knowledge; 2) what they learn needs to be connected to what they already know; and 3) they retain more if the new information is related to their everyday lives. We have begun a redesigned, two semester introductory biology course that applies how people learn best and reverts biology back to a science rather than a foreign language overburdened with jargon and memorization. We focus on the big ideas of biology and address each big idea at five different levels of organization. We include BioMath Explorations to help students understand that math enhances their biology understanding. We use ELSI (ethical, legal, social implications) case studies to connect the content with their daily lives. Class time is structured like a journal club where students discuss data and the significance of the results.

3:30 pm Integration of Science Writing in Laboratory Courses. Alice Rushforth. Massachusetts Institute of Technology.

Introduction to Experimental Biology and Communication (Course 7.02) is a laboratory course offered by the MIT Department of Biology. The course enrolls up to 100 undergraduates and provides an opportunity to learn experimental techniques in molecular biology, biochemistry, genetics, and cell and developmental biology. The course integrates factual knowledge with experimental design and data analysis to prepare students for subsequent independent research projects. In addition, there is a scientific communications component designed to develop writing and presentation skills critical for communicating scientific findings in modern biology. As an introductory level course and a degree requirement for a number of institute departments, Course 7.02 poses a particular challenge to developing an engaging and educational experience for students with a broad range of previous laboratory experiences and from a wide variety of areas of major study.

7.02 is fundamentally a laboratory course. Each week students attend two 4-hour laboratory sessions and two lectures that provide conceptual information important for understanding the techniques performed in the lab. The 12-week laboratory component of 7.02 is divided into three modules. The first module emphasizes protein biochemistry; students perform site-directed mutagenesis, express and purify the mutant protein and then assay mutant protein function. During the second module students use a yeast surface display system to explore protein engineering by directed evolution. In the third module, students use molecular genetic methods to perform five experiments pertaining to genetics, development, anatomy, and behavior in Caenorhabditis elegans.

In order to meet the scientific communications course component requirements students complete a variety of written and oral assignments that vary in length, content, and purpose. In the first two modules students learn how to effectively maintain a laboratory notebook. In the third module students write 3-5 page lab reports presenting the results from the experiments they perform. The lab reports are designed to be a more formal scientific communication than the lab notebooks and focus on data analysis and data presentation with particular attention to effective tables and figures.

As a Communication Intensive course, 7.02 students also write a 12-16 page scholarly paper, in journal format, reporting their results from the experiments in the first module. Writing instructors from the Writing Across the Curriculum (WAC) program mentor students throughout the paper writing process. WAC is an interdepartmental program that supports the integration of writing and speaking instruction into all undergraduate departments and programs. The WAC Writing Instructors meet with 7.02 students for five 2-hour sessions during the semester and provide explicit writing instruction and a structured writing and revision protocol with specific feedback so that students learn how to write a clear and effective scientific paper.

Based on the belief that with effective communication comes greater understanding, incorporating scientific communication skills in laboratory courses should challenge students to think more deeply about their work. Furthermore, it is essential that scientists develop strong communication skills if the potential of new scientific concepts and discoveries are to be fully realized.

15 Workshops

Saturday, June 12 2:00 PM–5:00 PM High-Throughput RNAi Screening in Model Systems Used to Study Human Biology at Genome Scale

Room: Constitution Ballroom A Organizers: Stephanie Mohr, Harvard Medical School and Dana Farber/Harvard Cancer Center, and Liz Perkins, Massachusetts General Hospital and Harvard Medical School

Workshop Goal: Attendees will leave the workshop with a solid understanding of the practical aspects of RNAi screening in cells and in vivo, including the types of questions that can be addressed with an RNAi screen and factors to consider when developing a screen assay. At the workshop, we will distribute a partial list of molecular and cellular reagents, equipment and facilities that facilitate RNAi screening in a variety of model systems.

Part I: Cell-Based RNAi Screening

Stephanie Mohr, PhD (Harvard Medical School), Introduction to cell-based RNAi screening: practical aspects, new developments and resources.

Meghana Kulkarni, PhD (Perrimon Lab; Harvard Medical School), The Power of Integrating Pathway-directed Proteomics and Functional genomics to dissect Signaling Networks.

Clemens Bergwitz, MD (Mass General Hospital), Using Drosophila RNAi technology to understand human disorders of phosphate homeostasis.

Greg Hoffman, PhD (Blenis Lab; Harvard Medical School), A functional siRNA screen identifies novel regulators of mTORC1 signaling.

Anju Singh, PhD (Glimcher Lab; Harvard School of Public Health), RNAi screen to identify novel anabolic regulators of bone development.

Part II: in vivo RNAi Screening

Liz Perkins, PhD (Massachusetts General Hospital), Introduction toin vivo RNAi screening in Drosophila, C. elegans and other systems.

Richelle Sopko, PhD (Perrimon Lab; Harvard Medical School), An optimized short hairpin microRNA library to examine early embryonic development in Drosophila.

Ralph Neumuller, PhD (Knoblich Lab; Research Institute of Molecular Pathology, Vienna, Austria), Genome wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.

Sylvia Fischer, PhD (Ruvkun lab; Massachusetts General Hospital),Genetic and genomic analysis of the negative regulation of RNAi in C. elegans.

Michael Hemann, PhD (Koch Institute/MIT), Performing loss of function screens in mice.

Monday, June 14 1:15 PM–3:15 PM Advanced DNA Sequencing Lunch and Workshop

Room: Constitution Ballroom Organizer: Mike Snyder

1:15 pm Lunch 1:45 pm Roche 2:05 pm From Discovery to Molecular Medicine with Life Technologies; Applied Biosystems’ Complete Sequencing Solutions, Graham Scott, Life Technologies 2:25 pm Illumina 2:45 pm Helicos Biosciences Corporation

16 PLATFORM SESSIONS The number above the title refers to the program number. The presenting author is in bold. Full abstracts can be found online at www.mohb.org

Saturday, June 12 6:45 PM–7:00 PM Saturday, June 12 9:15 PM–10:00 PM Grand Ballroom Grand Ballroom

Welcome and Opening Remarks Keynote Address

Fred Winston, Meeting Chair and GSA Past President Modeling connections: telomeres and human disease. Carol Greider. Johns Hopkins Medical School. Scott Hawley, Meeting Co-chair and GSA President Sunday, June 13 8:15 AM–8:30 AM Sherry Marts, GSA Executive Director Grand Ballroom

Genetics Society of America Award Saturday, June 12 7:00 PM–9:00 PM Presentations Grand Ballroom Edward Novitski Prize presented by Scott Hawley to Personal Genomics Tom Cline, University of California, Berkeley

Co-Moderators: Chuck Langley, University of CA, Davis GSA Medal presented by Fred Winston to and David Altshuler, Harvard Medical School and Barbara Meyer, University of California, Berkeley Massachusetts General Hospital

1 - 7:00 Sunday, June 13 8:30 AM–10:30 AM Genomic Variation and the Inherited Basis of Common Grand Ballroom Disease. David M. Altshuler.

Sex and Gene Expression 2 - 7:24

Dissection of genetically complex traits with extremely Co-Moderators: Barbara Meyer, University of CA, large pools of yeast segregants. Leonid Kruglyak. Berkeley and Melissa Hines, University of Cambridge

3 - 7:48 7 - 8:30 Whole genome analysis of polymorphism and divergence Targeting X Chromosomes for Repression. Barbara J. in Drosophila melanogaster. Charles H. Langley. Meyer.

4 - 8:12 8 - 8:54 Genome wide association study of sleep in Drosophila. Abstract unavailable at time of print. David Page. Susan T. Harbison, Julien F. Ayroles, Yi Han, Dianhui Zhu, Rui Chen, Richard Gibbs, Stephen Richards, Trudy F. C. 9 - 9:18 Mackay. Mechanisms underlying sexual differentiation of the brain and behavior. Nirao M. Shah. 5 - 8:24 Complete genome sequencing and analysis of diploid 10 - 9:30 African-American and Mexican-American genomes: Mechanistic insights into Disorders of Sex Development implications for personal ancestry reconstruction and from human mutations and mouse models. L. Ludbrook, multi-ethnic medical genomics. Carlos D. Bustamante. S. Bagheri-Fam, A. Argentaro, V. Harley.

6 - 8:48 11 - 9:42 Analysis of Multiple Phenotype Data in Genome-Wide Pink or Blue? Genetic Influence on Sex Differences in the Association Studies. Geraldine Clarke, Andrew Morris. Brain. Eric Vilain.

12 - 10:06 Sexual differentiation of human brain and behavior. Melissa Hines. 17 PLATFORM SESSIONS The number above the title refers to the program number. The presenting author is in bold. Full abstracts can be found online at www.mohb.org

Sunday, June 13 11:00 AM–1:00 PM Sunday, June 13 3:30 PM–5:30 PM Grand Ballroom Grand Ballroom

Models of Disease Cancer as a Genetic Disease

Co-Moderators: Susan Lindquist, Whitehead Institute and Co-Moderators: Angelika Amon, Massachusetts Institute Massachusetts Institute of Technology and Rick Lifton, of Technology and Phil Beachy, Stanford University Yale University School of Medicine School of Medicine

13 - 11:00 19 - 3:30 Can Simple Cells Model Complex Diseases? Susan Genetic Analysis of Patterning and Morphogenesis in the Lindquist. Mouse Embryo. Kathryn V. Anderson.

14 - 11:24 20 - 3:54 Abstract unavailable at time of print. Rick Lifton. The H3K27me3-demethylase dUTX is a suppressor of Notch- and Rbf-dependent tumors in Drosophila. 15 - 11:48 Andreas Bergmann. MicroRNA Control of Cardiovascular Development and Disease. Eric N. Olson. 21 - 4:06 Pathways that prevent genome instability: from model 16 - 12:12 organisms to human cancer. Richard Kolodner. Chromosome Instability and Synthetic Lethality In Yeast and Cancer. Philip A. Hieter, Peter Stirling, Jessica 22 - 4:30 McLellan, Derek van Pel, Jan Stoepel, Sean Minaker, Alina Abstract unavailable at time of print. Phil Beachy. Chan, Irene Barrett, Megan Kofoed, Payal Sipahimalani, Karen Yuen, Shay Ben-Aroya, Kirk McManus. 23 - 4:54 Life without the SUN: Suppression of MPS3 deletion by 17 - 12:36 changes in nuclear pore complex composition. Jennifer Insights into a Novel Non-syndromic Form of Mental M. Friederichs, Keren L. Witkin, Suman Ghosh, Orna Retardation/Intellectual Disability Through Studies that Cohen-Fix, Sue L. Jaspersen. Exploit both S. cerevisiae and Drosophila. Anita H. Corbett, ChangHui Pak, Masoud Garashabi, Christoph 24 - 5:06 Brockman, Luciano Apponi, Seth M. Kelly, John Noto, Consequences of aneuploidy. Angelika Amon. Brenda Huang, Sara Leung, Murray Stewart, Andreas Kuss, Kenneth Moberg. Sunday, June 13 7:15 PM–7:30 PM 18 - 12:48 Grand Ballroom Cancer drugs on the fly: whole-animal chemical screening in Drosophila identifies drugs controlling intestinal stem Genetics Society of America Award cell tumor growth and differentiation. Michele Presentation Markstein, Djade Soumana, Julio Cho, Norbert Perrimon.

Thomas Hunt Morgan Medal presented by Jim Haber to Alexander Tzagoloff, Columbia University

18 PLATFORM SESSIONS The number above the title refers to the program number. The presenting author is in bold. Full abstracts can be found online at www.mohb.org

Sunday, June 13 7:30 PM–8:15 PM Monday, June 14 11:00 AM–1:00 PM Grand Ballroom Grand Ballroom

Keynote Address Modern Approaches to Pathogenesis and Infectious Disease C. elegans poison detection pathways. Gary Ruvkun.

Harvard Medical School and Massachusetts General Co-Moderators: Gerry Fink, Whitehead Institute and Hospital. Massachusetts Institute of Technology and Joe DeRisi, University of CA, San Francisco

Monday, June 14 8:30 AM–10:30 AM 31 - 11:00 Grand Ballroom Model Organisms ---the Lifeline to Infectious Diseases and their Treatment. Gerald R. Fink. Neurogenetics: from Synapses to Senescence 32 - 11:24 Co-Moderators: Barry Ganetzky, University of WI, Gauging the Pathogenicity of Pandemic Influenza Viruses. Madison and Pamela Sklar, Harvard Medical School nad Peter Palese. Massachusetts General Hospital 33 - 11:48 25 - 8:30 Evolution of Transcriptional Circuitry: a Lesson from Clathrin is not required for clathrin-mediated Pheromone-mediated Biofilm Response in the Infectious endocytosis. Erik Jorgensen. Yeast Candida albicans. Song Yi, Nidhi Sahni, Karla J. Daniels, Guanghua Huang, Thyagarajan Srikantha, David 26 - 8:54 R. Soll. Genetic and molecular analysis of synaptic development in natural populations of Drosophila. Megan Campbell, 34 - 12:00 Barry S. Ganetzky. Amoeba, macrophage and myoviridae....more in common than just a bag of m&m's? John Mekalanos. 27 - 9:18 Neuroligin-deficient mutants of C. elegans have sensory 35 - 12:24 deficits and are hypersensitive to oxidative stress. James Age-dependent dynamics of the role of DAF-16/FOXO in B. Rand, Gregory P. Mullen, Jessica M. Heatherly, Jerrod C. elegans host defense. Matthew J. Youngman, Dennis W. Hunter. H. Kim.

28 - 9:30 36 - 12:36 DISC1 and Wnt Signaling in Psychiatric Disease. Singh Genomics and Infectious Disease. Joe DeRisi. Karun, Yingwei Mao, Li-Huei Tsai.

29 - 9:54 Bipolar Disorder and Schizophrenia Genomics. Pamela Sklar.

30 - 10:18 VPS41-mediated Neuroprotection in C. elegans and Mammalian Models of Parkinson’s Disease. A. J. Harrington, Q. Ruan, J. Schieltz, D. G. Standaert, K. A. Caldwell, G. A. Caldwell.

19 PLATFORM SESSIONS The number above the title refers to the program number. The presenting author is in bold. Full abstracts can be found online at www.mohb.org

Monday, June 14 3:30 PM–5:30 PM Monday, June 14 7:30 PM–8:15 PM Grand Ballroom Grand Ballroom

Stem Cell: the Genetics of Commitment Keynote Address

Co-Moderators: Minx Fuller, Stanford University and Common Pathways and Individual Differences: From George Daley, Harvard Medical School and Children's Model Organisms to Medicine. Jeremy Berg. National Hospital Institute of General Medical Sciences.

37 - 3:30 Developmental tumor suppressors and regulation of the switch from proliferation to differentiation in adult stem cell lineages. Megan Insco, Alexis Bailey, Margaret Fuller.

38 - 3:54 Directing and redirecting cell fates. George Daley.

39 - 4:18 Biological roles of Tet-family proteins, enzymes that convert 5-methylcytosine to 5-hydroxymethyl-cytosine in DNA. Anjana Rao, Kian Koh.

193A - 4:30 Fragile X Protein Controls Neural Stem Cell Proliferation and Exit from Quiescence in the Drosophila Brain. Matthew A. Callan, Samantha Luois, Clemens Cabernard, Chris Q. Doe, Daniela C. Zarnescu.

40 - 4:42 Regulation of human neural crest enhancer elements by chromatin remodeling proteins in normal and pathological development. Ruchi Bajpai, Alvaro Rada, Samantha Brugmann, Tomek Swigut, Joanna Wysocka.

41 - 5:06 Cyclin E/CDK-2 regulates proliferative cell fate and cell cycle progression in the C. elegans germline. Paul Fox, Valarie Vought, Eleanor Maine, Tim Schedl.

42 - 5:18 Characterization of a novel mouse model for Lesch- Nyhan Disease. Alaine Keebaugh, Heather Mitchell, Jamie Davis, Meriem Gaval-Cruz, Kimberly Freeman, Gaylen Edwards, David Weinshenker, James Thomas.

20 PLATFORM SESSIONS The number above the title refers to the program number. The presenting author is in bold. Full abstracts can be found online at www.mohb.org

Tuesday, June 15 8:30 AM–10:30 AM Tuesday, June 15 11:00 AM–1:00 PM Grand Ballroom Grand Ballroom

Organismal Architecture and Developmental Analyzing Genomes Disabilities Co-Moderators: Barbara Wold, CalTech and

Co-Moderators: Olivier Pourquie, Stowers Institute for Joe Ecker, The Salk Institute Medical Research and Matt Warman, Harvard Medical School and Children's Hospital 49 - 11:00 Building and interpreting genome-wide maps of 43 - 8:30 chromatin structure and transcription factor occupancy. The genetic architecture of ciliopathies. Nicholas Barbara Wold. Katsanis. 50 - 11:24 44 - 8:54 Sequencing Epigenomes of Plants and People. Joseph R. Patterning of the vertebrate axis. Olivier Pourquie. Ecker.

45 - 9:18 51 - 11:48 Using mouse mutagenesis to query neurodevelopment Programming Embryonic Stem Cell State. Richard A. and cortical patterning. David Beier. Young.

46 - 9:42 52 - 12:12 Genetic screens in mice and in humans are unbiased by Developmental drift and aging stochasticity in C. elegans. preconceptions regarding gene function. Matthew Stuart Kim. Warman. 53 - 12:36 47 - 10:06 Genome-wide detection of signatures of selection in Modeling Spinal Muscular Atrophy in Drosophila links stickleback. Pamela Russell, Manfred Grabherr, Evan SMN to FGF signaling. Anindya K. Sen, Takakazu Mauceli, Frank Chan, Felicity Jones, Jessica Alfoldi, Yokokura, Mark William Kankel, Douglas Dimlich, Jeremy Johnson, David Kingsley, Federica Di Palma, Guruharsha Kuthethur, David Van Vactor, Anne Hart, Kerstin Lindblad-Toh, Broad Institute Sequencing Spyros Artavanis-Tsakonas. Platform.

48 - 10:18 54 - 12:48 Modeling Congenital Muscle Diseases: Insights from the Yeast evolutionary genomics: comparative and Zebrafish. David Grunwald, Michael Jurynec, Derrick experimental approaches. Bernard A. Dujon. Gunther.

21 POSTER SESSIONS Poster board number is in bold above the title. The name of the presenting author is in bold. Full abstracts can be found online at www.mohb.org Personal Genomics 63A Oxygen deprivation induces a late-prophase cell cycle

55A checkpoint involving nucleoporin NPP-16/NUP50, HDA- Genetic diversity in lysosomal disorders in Portugal. Olga 2/HDAC and CDK-1 in C. elegans. Pamela Padilla, Vinita Amaral, Ana Duarte, Diogo Ribeiro, Isaura Ribeiro, Hajeri, Mary Ladage. Eugenia Pinto, Pedro Oliveira. 64B 56B Bacterial Infection and Genetic Background Synergize to A study of functional differences between alleles in P450 Induce Intestinal Dysplasia. Chrysoula Pitsouli, Yiorgos genes for medaka fish. Takafumi Katsumura, Shoji Oda, Apidianakis, Laurence Rahme, Norbert Perrimon. Hiroshi Mitani, Shoji Kawamura, Hiroki Oota. 65A Cancer as a Genetic Disease Cell cycle functions of xpd. Beat Suter, Olivier Urwyler, Xiaoming Li, Karin Stettler.

57A Direct detection of rare circulating tumor cells in blood 66B by castPCR. Ruoying Tan, Pius Brzoska, Yun Bao, Caifu Evidence of a Rad51-independent role for Drosophila Chen. Brca2 in the repair of camptothecin-induced DNA damage. Adam M. Thomas, Endry Martinez, Adam 58B South, Carrie Hui, Daniel Kane, Mitch McVey. The Pattern of Evolution in Somatic Cancer Mutations of Human mtDNA. E. B. Chen-Quin, Y. Xie, P. Stafford. 67A A genetically modified cancer cell line model suppresses 59A tumorigenicity and identifies pathways important in The Role of Basigin/EMMPRIN in Mediating Normal Cell ovarian cancer. Patricia N. Tonin, Karen Gambaro, Diane Structure. Kathryn D. Curtin. Provencher, Anne-Marie Mes-Masson.

60B 68B Notch mediated regulation of cell proliferation in Gene expression study in gastric cancer and the development and disease. Pallavi Kshetrapal, Diana Ho, identification of diagnosis and prognosis candidates in Spyros Artavanis-Tsakonas. two batches of surgical samples. Yuezheng Zhang, Shuqin Jia, Chaohua Li, Deyun Niu, Lianhai Zhang, Jiafu Ji, 61A Changqing Zeng. Demethylation and Re-expression of Imprinted and Tumor Suppressor Genes by HDAC Inhibitors and Calpain Inhibitors. Megan A. Mataga, Leah R. Evans, Jenny E. Loew, Jasmine Corona, Tiffany Loken, Sibaji Sarkar.

62B Loss of the Bloom Syndrome helicase results in spontaneous genome rearrangements, tumorigenesis, and reduced longevity in Drosophila melanogaster. Ana Maria Garcia, Robert Salomon, Alice Witsell, Justine Liepkalns, Martha Lundell, R. Brent Calder, Jan Vijg, Mitch McVey.

Even-numbered “A” posters: Sunday, 8:15 PM-9:45 PM; Odd-numbered “A” posters: Sunday 9:45 PM-11:15 PM Even-numbered “B” posters: Monday, 8:15 PM-9:45 PM; Odd-numbered “B” posters: Monday 8:15 PM-11:15 PM

PRESENTATIONS: Posters are located in Back Bay A/B/C

POSTER SESSIONS Poster board number is in bold above the title. The name of the presenting author is in bold. Full abstracts can be found online at www.mohb.org

Models of Disease 76B Elucidating the Chaperone Mechanism of Human

69A TorsinA. Alexander Burdette, Perry Churchill, Pan Chen, Genome-wide Association Analysis of Antibody-mediated Guy Caldwell, Kim Caldwell. Murine Arthritis. Vyacheslav A. Adarichev. 77A 70B GDF-15 does not regulate hepatic hepcidin levels in Endothelial Overexpression of LOX-1 Increases Aortic erythropoiesis-challenged mice. Guillem Casanovas, oxLDL Uptake, Induces Endothelial Dysfunction and Klaus Unsicker, Matthias W. Hentze, Martina U. Plaque Formation in vivo. Role of Transcription Factors Muckenthaler. NFB and Oct-1. Alexander Akhmedov, Izabela 78B Rozenberg, Yi Shi, Carola Doerries, Pavani Mocharla, A role of von Willebrand Factor in secretion control of Alexander Breitenstein, Christine Lohmann, Sokrates Coagulation Factor VIII. Chan Young Cho, Hyun Joo Kim, Stein, Tobias von Lukowicz, Jan Borén, Felix C. Tanner, Ulf Sang Won Park, Sang-Yun Choi. Landmesser, Christian M. Matter, Thomas F. Luescher. 79A 71A A Drosophila Parkinson's Disease model which includes a DNA copy number variation in dog breeds. Carlos E. neuroinflammatory response. Joseph G. Daigle, Arati Alvarez, Jennie L. Rowell. Inamadar, Janis O'Donnell.

72B 80B Somatic genetic and epigenetic events in murine models Caenorhabditis elegans as a model to study drug-induced of human colon cancer. James Amos-Landgraf, Anthony mitochondrial toxicity. Richard de Boer, Hans van der Hunter, Cory Hartman, Amy Irving, William Dove. Spek, Stanley Brul.

73A 81A Plant flavonoids arrest tumour and induce p21WAF-1 by Study of the splicing factor PRP8 in drosophila eyes. remodelling chromatin of STAT response element. Utpal Daniela Cavaliere, Ennio Giordano, Filomena Anna Bhadra, Jhillu S. Yadav, Anita Krishnan, Suresh Babu K., Digilio. Ashok Kumar Tiwari, Madhusudhana Rao, Manika Pal- Bhadra. 82B Development and characterization of a novel Drosophila 74B model for FRAXE heritable non-syndromic mental A Pleiotropic Skeletal QTL on Mouse Chromosome 4. retardation. Ginnene DiStefano, Daniel Marenda. Neema Saless, In Kyu Han, Suzanne J. Litscher, Ray Vanderby, Peter Demant, Robert D. Blank. 83A Yeast as a tool to validate mutations in genes involved in 75A metabolic disorders. Mara Doimo, Eva Trevisson, NFAT expression and localization in the mandibular Leonardo Salviati. precursor of Ts65Dn Down syndrome mice. Joshua D. Blazek, Brady Harman, Anna Gaddy, Samantha Deitz, 84B Randall J. Roper. Losartan Ameliorates Disease in a Murine Model of Axial Myopia. J. J. Doyle, H. C. Dietz.

PRESENTATIONS: Posters are located in Back Bay A/B/C

POSTER SESSIONS Poster board number is in bold above the title. The name of the presenting author is in bold. Full abstracts can be found online at www.mohb.org 85A 94B Splice defect-induced myopathy: a Drosophila model. The cleavage product of the Drosophila Collagen 18, Isabelle Draper, Meg Tabaka, Ci Chen, Gordon Huggins, Endostatin, is crucial for the establishment of the Matthew Wolf, Robert Salomon. embryonic heart lumen and valve morphogenesis. Nofar Harpaz, Talila Volk. 86B APL-1, an amyloid precursor-related protein, influences 95A the activity of lifespan-determining transcription factor Separable roles for C. elegans ASNA-1 in metal drug DAF-16/FOXO in C. elegans. Collin Ewald, Chris Li. sensitivity and insulin signaling. Oskar Hemmingsson, Gautam Kao, Maria Still, Peter Naredi. 87A Cell Cycle Checkpoint Responses to Damage at Expanded 96B CAG/CTG Repeats. Rangapriya Sundararajan, Catherine Molecular Mechanisms of Robustness to Oxygen and H. Freudenreich. Temperature Stress. Farhad B. Imam, Alex Schier.

88B 97A SPT regulation via micro-RNA in response to dietary Drosophila melanogaster: Model to study fungal volatile changes. Hirosha Geekiyanage, Christina Chan. organic compound (VOC)-mediated toxicity. Arati A. Inamdar, Prakash Masurekar, Joan Bennett. 89A Degradation of soluble and polymeric alpha-1 antitrypsin 98B in a yeast model. Cristy L. Gelling, Jeffrey L. Brodsky. One gene, two mutations, two different spontaneous prion diseases. Walker S. Jackson, Susan Lindquist. 90B Caenorhabditis elegans as chemical screening tool to find 99A compounds and targets against neuromuscular diseases. Post-Developmental Role of HDA-1 in the Cytoskeletal Jean Giacomotto, Laurent Ségalat. control of GABAergic Neurotransmission in an Epilepsy Model of C. elegans. Bwarenaba B. Kautu, Kalen P. Perry, 91A Matthew L. Hicks, S. Kyle Lee, Cody J. Locke, Kim A. Characterizing a Long-lived coq-3 Mutant in Caldwell, Guy A. Caldwell. Caenorhabditis elegans. Fernando Gomez, Ryoichi Saiki, Randal Chin, Chandra Srinivasan, Catherine Clarke. 100B Identifying Genetic Factors Associated with Aging that 92B Influence -Synuclein Toxicity. A. L. Knight, S. Next-generation gene targeting in the mouse: allelic Hamamichi, M. Zhang, A. R. Borom, S. M. DeLeon, S. K. series of point mutations for human disease modeling. Lee, J. Schieltz, K. A. Caldwell, G. A. Caldwell. Yoichi Gondo, Ryutaro Fukumura, Takuya Murata, Shigeru Makino. 101A Mouse Models of Human Disease - phenotype and model 93A data from the Mouse Genome Informatics (MGI) Establishment of S. cerevisiae as a Model Organism for resource. Michelle N. Knowlton, Howard Dene, Monika Studying the Anticancer Ruthenium Complex KP1019. Tomczuk, Randy Babiuk, Kim L. Forthofer, Jill Lewis, Amy P. Strehle, Laura K. Stultz, Pamela K. Hanson. James A. Kadin, Jon S. Beal, Susan M. Bello, Cynthia L. Smith, Janan T. Eppig.

PRESENTATIONS: Posters are located in Back Bay A/B/C

POSTER SESSIONS Poster board number is in bold above the title. The name of the presenting author is in bold. Full abstracts can be found online at www.mohb.org 102B 110B Yeast as a model for lipotoxicity and the metabolic FIG4, neurodegeneration and disease: mouse to yeast to syndrome. Sepp D. Kohlwein, Harald Hofbauer, Heimo human and back. Miriam H. Meisler, Cole Ferguson, Guy Wolinski, Sandra Herrman, Julia Petschnigg, Oskar Lenk. Knittelfelder, Gerald Rechberger, Oksana Tehlivets. 111A 103A O-GlcNAc Cycling and Insulin Signaling Respond to Family matters; Cardiovascular phenotypes of WT and Nutrient Stress in C. elegans. Michelle A. Mondoux, Elastin heterozygous animals are modified by mouse Dona C. Love, Salil Ghosh, John A. Hanover, Michael W. strain background. Beth A. Kozel, Russell H. Knutsen, Li Krause. Ye, Christopher Ciliberto, Thomas Broekelmann, Robert P. Mecham. 112B Evidence for Target of Rapamycin (TOR)-independent 104B functions of the Tuberous Sclerosis Complex (TSC) A Drosophila Model for Fibrodysplasia Ossificans Homologs in Fission Yeast. Nicole A. Neuman, Faina Progressiva (FOP). Viet Le, Kristi Wharton. Myachina, Elizabeth Henske.

105A 113A A Mouse Model of Glycogen Storage Diseases IV Suppression of Tumorigenesis by the Novel Genetic Delineates a Key Role of Glycogen-Branching Enzyme in Modifier Locus, Mom4, in the ApcMin Mouse Model of Maintaining Glycogen Homeostasis and Embryonic Intestinal Cancer. Stephanie C. Nnadi, Revati Koratkar, Cardiac Development. Yi-Ching Lee, Chia-Jung Chang, Yu- Arthur M. Buchberg, Linda D. Siracusa. Ting Yan, Yuan-Tsong Chen. 114B 106B Effects of Pax3 mutation and neural crest genetic Mutant TDP-43 has enhanced toxicity in a C. elegans ablation on congenital heart function and embryonic model of ALS. Nicole F. Liachko, Chris R. Guthrie, Brian C. lethality. Michael Olaopa, Dona M. Chikaraishi, Paige Kraemer. Snider, Hong-Ming Zhou, Simon J. Conway.

107A 115A An alternative approach to Beta-Thalassemia therapy: Reduction of Wunen, a Lipid Phosphate Phosphatase 3 Human delta globin gene activation in transgenic mice. homolog, suppresses the muscle degeneration Maria F. Manchinu, Susanna Porcu, Maria F. Marongiu, phenotype associated with dystrophic flies. Mario Daniela Poddie, Francesca Crobu, Carla Casu, Maria S. Pantoja, Karin Fischer, Hannele Ruohola-Baker. Ristaldi. 116B 108B Investigating the role of Caveolin-1 during the Mapping canine complex traits as models of human development of atherosclerosis. Stephanos Pavlides, disease. Evan Mauceli, Kate Meurs, Maria Wilbe, Elinor Sanjay Katiyar, Jean-François Jasmin, Isabelle Mercier, K. Karlsson, Kerstin Lindblad-Toh. Rhonda Walters, Iset Vera, Diana Whitaker-Menezes, Richard G. Pestell, Jan L. Breslow, Michael P. Lisanti, 109A Philippe G. Frank. Overexpression of minibrain produces a model of Down Syndrome in Drosophila melanogaster. Rebecca M. S. 117A Mawhinney, Brian E. Staveley. The antidepressant sertraline targets intracellular vesiculogenic membranes in yeast. Ethan O. Perlstein, Meredith Rainey, Daniel Korostyshevsky, Sean Lee.

PRESENTATIONS: Posters are located in Back Bay A/B/C

POSTER SESSIONS Poster board number is in bold above the title. The name of the presenting author is in bold. Full abstracts can be found online at www.mohb.org 118B 127A Modeling Parkinson’s Disease in Saccharomyces The akt of Survival: Novel akt mutants are Able to Endure cerevisiae. Doris Petroi, Naimeh Taheri-Talesh, Gerhard Amino-Acid Starvation. Jennifer D. Slade, Brian E. Braus. Staveley.

119A 128B Mutations in mitochondrial tRNA sythetase cause ovarian Heart miRNA cloning in cardiomyopathic (J2N-k) and dysgenesis and hearing loss of Perrault Syndrome. Sarah normal (J2N-n) Syrian hamsters. Osamu Suzuki, Minako B. Pierce, Karen M. Chisholm, Tom Walsh, Elinor Adman, Koura, Yoko Noguchi, Kozue Uchio-Yamada, Junichiro Weiqing Li, Eric Lynch, Mary-Claire King. Matsuda.

120B 129A An essential role for the Unfolded Protein Response in Preliminary Analysis of Parkinson’s Disease Models in host protection against innate immune activation in C. Drosophila melanogaster. Jimmy A. Symonds, Alfred T. elegans. Claire E. Richardson, Tristan Kooistra, Dennis H. Villaluz, Matt B. Mahoney, Lenard Diggins, Phil O’Neil, Kim. Carol M. Singh.

121A 130B Bridging gaps between models and humans: The value of Modeling Machado-Joseph disease pathogenesis in diversity and variability. Jason S. Robert. Caenorhabditis elegans. Andreia Teixeira-Castro, Rick Morimoto, Patrícia Maciel. 122B Genetically engineered mouse models. S. Rockwood, J. 131A Beckwith, C. Heffner, C. Lutz, S. Murray, M. Sasner, L. Novel anti-aging compounds extend yeast life span by Donahue. targeting a programmed necrotic cell death pathway. Vladimir Titorenko, Alexander Goldberg, Pavlo Kyryakov, 123A Simon Bourque, Michelle Burstein, Adam Beach, Vincent Altered mandibular development in Down syndrome Richard, Anastasia Glebova, Mylene Juneau. mouse model linked to modified expression of non- trisomic homeobox genes. Randall J. Roper, Cherie N. 132B Billingsley, Jared A. Allen, Joshua D. Blazek, Douglas D. By increasing the level of cardiolipin, a novel anti-aging Baumann, Abby Newbauer, Andrew Darrah, Mark compound modulates many longevity- and disease- Clement, R. W. Doerge. related processes in yeast mitochondria. Vladimir Titorenko, Alexander Goldberg, Pavlo Kyryakov, Simon 124B Bourque, Michelle Burstein, Adam Beach, Vincent Fat Flies: Effects of a high-fat diet in Drosophila. Erilynn Richard, Anastasia Glebova, Mylene Juneau. Russo, Gabriel Haddad. 133A 125A Parkinson Disease genes, PINK1 and parkin, show HIF-1 antagonizes CEP-1/p53-mediated apoptosis via a complex roles involving both cellular protection and secreted neuronal tyrosinase. Ataman Sendoel, Ines aspects of growth regulation in Drosophila. Amy M. Kohler, Christof Fellmann, Scott Lowe, Michael Todd, Brian E. Staveley. Hengartner.

126B Autosomal recessive primary open-angle glaucoma (POAG) in beagles: Candidate gene analysis. Barkur S. Shastry, Kato Kumiko, A. Kamida, N. Sasaki.

PRESENTATIONS: Posters are located in Back Bay A/B/C

POSTER SESSIONS Poster board number is in bold above the title. The name of the presenting author is in bold. Full abstracts can be found online at www.mohb.org

134B Sex and Gene Expression Investigation of the neuroprotective role of GIPC in a C. elegans model of Parkinson’s Disease. Michelle L. Tucci, 142B Laura A. Berkowitz, Shusei Hamamichi, Guy A. Caldwell, Mouse models of dosage-sensitive sex reversal reveal Kim A. Caldwell. roles for Wt1 and Sf1 in regulating Sry expression and supporting cell precursor differentiation. Stephanie M. 135A Correa, Ravi S. Kahlon, Kenneth H. Albrecht. Characterization of the mechanism by which the BTB/POZ zinc finger protein, Abrupt mediates 143A tumorigenesis in Drosophila. Nezaket Türkel, Tony A sexually dimorphic role for the SUP-9 K+ channel in C. Brumby, Karen Goulding, Jessica Bolden, Sergi Beltran elegans. Elizabeth A. De Stasio, Dan Berg, Paul Stevens. Agulló, Enrique Martin Blanco, Helena Richardson. 144B 136B Reactive oxygen species (ROS) cause mitochondrial Zebrafish as a new model to study mitochondrial disease. morphology damage and reduced yeast spore viability Bianca van den Bosch, Marie Winandy, Auke Otten, René during meiosis that can be reversed by overexpression of de Coo, Marc Muller, Hubert Smeets. ZWF1. Tricia Brown, Michelle Scott, Christopher Daldine, Steven W. Gorsich. 137A A role for Integrins during lumen formation in Drosophila 145A heart development. Jessica L. Vanderploeg, Luz de Association studies of AR, ER AND CYP19 repeat length Lourdes Vazquez Paz, Roger Jacobs. polymorphisms in male-to-female transsexuals. Lauren Hare, Pascal Bernard, Cisco Sanchez, Eric Vilain, Trudy 138B Kennedy, Vincent R. Harley. Genetic Networks Affecting Natural Variation in Oxidative Stress Resistance, Longevity and Senescence in 146B Drosophila. Allison L. Weber, Elizabeth Ruedi, Terry G. Meiotic recombination provokes functional activation of Campbell, George F. Khan, Lenovia McCoy, Elizabeth the p53 regulatory network . Wan-Jin Lu, Joseph Chapo, Jones, Crystal L. Tabor, Robert R. H. Anholt, Trudy F. C. Ignasi Roig, John Abrams. Mackay. 147A 139A Gene expression profile of peripheral WBC differs among Abnormalities in Rhomboid-3 cause a dilated ethnic groups with type 2 diabetes. Jinghe Mao, Junmei cardiomyopathy in adult Drosophila. Lin Yu, Teresa Lee, Ai, Marketta Blue, Ming Shenwu, Adrienne Wells, Na Lin, Matthew Wolf. Youping Deng.

140B 148B PP1 phosphatases play crucial roles in male fertility from Sex determination in the silkworm,Bombyx mori: W worms to mammals. J.-C. Wu, A. Go, T. Cintra, M. chromosome-linked C3H and C2H2-type zinc finger genes Samson, S. Mirsoian, I. Omoruyi, M. Jao, T. Wu, D. Chu. are candidate upstream regulators of the sex determination pathway. Venkatesan Sathish, Masahiro 141A Ajimura, Jayendra Nath Shukla, Ken Sahara, Hiroaki Abe, A Genome-wide RNAi Screen for Modifiers of Aggregates Toshiki Tamura, Toru Shimada, Kazuei Mita, Formation by Mutant Huntingtin in Drosophila. Sheng Javaregowda Nagaraju. Zhang, Richard Binari, Rui Zhou, Norbert Perrimon.

PRESENTATIONS: Posters are located in Back Bay A/B/C

POSTER SESSIONS Poster board number is in bold above the title. The name of the presenting author is in bold. Full abstracts can be found online at www.mohb.org 149A 157A Structural destabilization of Y chromosomes in Temperature and daf-2 regulated ins gene expression interspecific backcrosses is consistent with variations in impact survival and development in C. elegans. Angela R. epigenetic modifications. Ferez S. Nallaseth, Z. Sheng Sanchez, Pamela L. Larsen. Guo. 158B 150B A calcium-selective cation channel (DSC1) modulates The dynamics of the human sex ratio from conception to neuronal excitability in Drosophila melanogaster. birth. Steven Orzack. Tianxiang Zhang, Ningguang Luo, Zhe Wang, Lingxin Wang, Zhiqi Liu, Chun-Fang Wu, Ke Dong. 151A A novel genetic screen to identify new factors controlling Pathogenesis and Infectious Disease dosage compensation in Drosophila. Mahalakshmi

Prabhakaran, Richard Kelley. 159A Lactoferrin induces apoptosis in Jurkat Leukemia T 152B lymphocytes. Hye-Min Hwang, Shin-Hee Lee, Sang-Yun The X-linked Mental Retardation Gene Jarid1c Regulates Choi. Cognitive Behaviors through Histone Demethylation and Transcriptional Repression of Genes Involved in 160B GABAergic Neurotransmission. Samuel Chang, Megan Novel roles for C. albicans AP-1, Cap1 and host dual Andreassi, Gavin Baxter-King, Kyra Berg, Jun Xu. oxidase, Bli-3 in fungal pathogenesis. Charu Jain, Benjamin Landry, Kelly Pastor, Reeta Prusty Rao. Neurogenetics: from Synapses to Senescence 161A

153A Frequent genetic variation in the STK10 gene and its Investigation of the effects of energetic nitrogen association with aspirin-intolerant asthma in Korean compounds on intracellular calcium signals. Cheng J. Cao, population. Jeong-Hyun Kim, Byung-Lae Park, Choon-Sik Desmond I. Bannon, Gunda Reddy, Mark S. Johnson. Park, Hyoung Doo Shin.

154B 162B A Conserved Signalling Pathway Promotes Wakefulness Development of a screen for the identification of in C. elegans. Julie Y. Cho, Paul W. Sternberg. Aspergillus adhesins. Sungsu Lee, Sreevardhini Venkatramen, Anne Dranginis, Diana Bartelt. 155A Knockdown of the neuropathy target esterase (Nte) in 163A zebrafish causes defects in mortor axon outgrowth and Characterizing the effects of a growth inhibitor on pathfinding. Yang Song, Molin Wang, Fei Mao, Yaoqin toxoplasma gondii. Tracy L. Meehan, Edwin Kamau, Gong. Gabriela Mustata, Jon Boyle.

156B 164B An in vivo screen in Drosophila may identify novel drugs Phosphorylation of the Conserved Transcription Factor to treat depression, anxiety and attention deficit ATF-7 by PMK-1 p38 MAPK Regulates Innate Immunity in disorder. Hakeem O. Lawal, Ashley N. Terrell, Richard Caenorhabditis elegans. Robert P. Shivers, Daniel J. Hadi, Jennifer Jang, Logan Roberts, Varun Shahi, Brian Pagano, Tristan Kooistra, Claire E. Richardson, Kirthi C. Huang, Mang-Ting Chou, David E. Krantz. Reddy, Janelle K. Whitney, Odile Kamanzi, Kunihiro Matsumoto, Naoki Hisamoto, Dennis H. Kim.

PRESENTATIONS: Posters are located in Back Bay A/B/C

POSTER SESSIONS Poster board number is in bold above the title. The name of the presenting author is in bold. Full abstracts can be found online at www.mohb.org 165A 171A From the Regulation of Biofilm Response in the Human Toward a comprehensive map of the Drosophila Fungal Pathogen Candida albicans to the Evolution of melanogaster interactome. Guruharsha Kuthethur, Jean- Signal Transduction Pathways. Nidhi Sahni, Song Yi, Karla François Rual, Bo Zhai, Julian Mintseris, Mark Stapleton, Daniels, Thyagarajan Srikantha, Claude Pujol, David R. Rogerio Candeias, Pujita Vaidya, Namita Vaidya, Saumini Soll. Shah, Kenneth Wan, Charles Yu, Joseph Carlson, Xiao Chen, Bhaveen Kapadia, Manolis Kellis, K. VijayRaghavan, Analyzing Genomes Steven Gygi, Susan Celniker, Robert Obar, Spyros Artavanis-Tsakonas.

166B Shadow Enhancers Improve Reliability of Gene 172B Expression. Alistair N. Boettiger, Michael Perry, Michael Locating Sites of Crossing-Over and Gene Conversion in Levine. Drosophila melanogaster using Whole Genome Sequencing and SNP Analysis. Danny Miller, Aaron Noll, 167A Satomi Takeo, Anoja Perera, Justin Blummenstiel, Kendra Evolution of Conserved Noncoding Element Enhancer Walton, Karen Staehling-Hampton, R. Scott Hawley. Activity in Mammals and Fish. Jeffrey H. Chuang, Deborah I. Ritter, Qiang Li, Dennis Kostka, Katherine S. 173A Pollard, Su Guo. Linking humans and horseshoe crabs: SNPs and Variations in Mitochondrial Cytochrome B (CYTB). Mary 168B J. Paolella, Dominika A. Bajguz, Maria A. Galluzzo, Lauren From Genotype to Phenotype: A Robust Method for J. LaChance, Katherine J. Lee, Allison M. Zeranski, Gene Identification Using Rapid High-Resolution SNP- Meghan M. Zwahlen. CGH Mapping and Whole-Genome Sequencing. Stephane Flibotte, Mark L. Edgley, Jon Taylor, Iasha Chaudhry, 174B Robert J. Barstead, Donald G. Moerman. Sequencing the Limulus Mitochondrial COX III Gene: 169A Comparison of Cytochrome Oxidase Complex SNPs to All Creatures Great and Small: Vertebrate Genome Those Causing Human Disease. Mary J. Paolella, Sequencing at the Broad Institute. Jeremy W. Johnson, Alexandra M. Buda, Roberta N. Delvy, Aleah M. George, Jessica E. Alföldi, Manfred Grabherr, Evan Mauceli, Jenna R. LaRiviere, Alexandria R. McPherson, Heather M. Pamela Russell, Ross Swofford, Eric S. Lander, Federica di Vicenty. Palma, Kerstin Lindblad-Toh, Broad Institute Sequencing Platform. 175A Genetic Architecture of the US population of the 170B Collaborative Cross. David Aylor, Darla Miller, Elissa The Mouse Genomes Project: Whole genome sequencing Chesler, Leonard McMillan, David Threadgill, William and analysis of 17 laboratory and wild-derived mouse Valdar, Gary Churchill, Fernando Pardo-Manuel de genomes. Thomas M. Keane, Jonathan Flint, Binnaz Villena. Yalcin, Jim Stalker, Kim Wong, Xinagchao Gan, Petr Danecek, Avigail Agam, Martin Goodson, Guy Slater, Ian 176B Jackson, Laura Reinholdt, Leah Rae Donohue, Steve When Association Mapping Succeeds, When It Fails, and Brown, Ewan Birney, Allan Bradley, Chris Ponting, Richard When It Goes Horribly Awry: lessons from Arabidopsis Mott, Richard Durbin, David Adams. thaliana. Alexander Platt, Bjarni Vilhjálmsson, Magnus Nordborg.

PRESENTATIONS: Posters are located in Back Bay A/B/C

POSTER SESSIONS Poster board number is in bold above the title. The name of the presenting author is in bold. Full abstracts can be found online at www.mohb.org 177A Organismal Architecture and Developmental Dynamic Evolution of Megasatellites in Yeasts. Thomas Disabilities Rolland, Bernard Dujon, Guy-Franck Richard.

185A 178B Drosophila beta-arrestin Kurtz regulates the immune Genetic analysis of individual differences in craniofacial system development. Saima Ghafoor Anjum, Alexey morphology using medaka. Minori Shinya, Tetsuaki Veraksa. Kimura, Atsuko Shimada, Noriyoshi Sakai, Hidetoshi Inoko, Hiroyuki Takeda, Kiyoshi Naruse. 186B In vivo analysis of signaling dynamics in the Notch 179A interaction network. Sukanya Basu, Kazuya Hori, Spyros Comparative genomics of nematodes. Paul W. Artavanis-Tsakonas, Alexey Veraksa. Sternberg, Ali Mortazavi, Erich M. Schwarz, Adler Dillman, Igor Antoshechkin. 187A Identification of Mechanisms Regulating Muscle Size and 180B Shape. Krista C. Dobi, Mary K. Baylies. RFX-mediated transcriptional rewiring of ciliary genes in animals. Brian P. Piasecki, Jan Burghoorn, Peter 188B Swoboda. The EL Mouse: A Natural Model of Autism and Epilepsy. Joshua Meidenbauer, John Mantis, Thomas Seyfried. 181A Deep segregation of single nucleotide polymorphisms 189A (SNPs) in East African cichlids. Ross W. Swofford, Y. H. A Novel CRL4/DCAF1 E3 ubiquitin ligase complex Eddie Loh, J. Todd Streelman, Federica Di Palma, Kerstin regulates ribosome biogenesis and nucleolar morphology Lindblad-Toh, Tilapia Sequencing Consortium. in C. elegans germ cells. Mohammad M. Rahman, Youngjo Kim, Rui Proenca, Edward Hedgecock, Edward 182B Kipreos. A ‘next-generation’ of methods for rapidly characterizing complex balanced rearrangements contributing to 190B developmental disorders. Michael Talkowski, Carl Ernst, CACN-1/Cactin interacts genetically with MIG-2 GTPase Bhavana Muddukrishna, Andrew Kirby, Carrie Hanscom, signaling to control distal tip cell migration in C. elegans. Adrian Heilbut, Toshiro Ohsumi, Mark Borowsky, Mark Hiba Tannoury, Varenka Rodriguez, Erin Cram. Daly, Cynthia C. Morton, James Gusella. 191A 183A Systematic analysis of tubular organ morphogenesis in Genome-wide association study of 107 phenotypes in Caenorhabditis elegans. Hongjie Zhang, Nessy Abraham, Arabidopsis thaliana inbred lines. Bjarni J. Vilhjálmsson, Liakot Khan, John Fleming, Verena Gobel. Yu S. Huang, Glenda Willems, Susanna Atwell, Alexander

Platt, Magnus Nordborg. Stem Cells: the Genetics of Commitment 184B Comparative genomics of Hammondia hammondi and 192B Toxoplasma gondii. Katelyn Walzer, Jon Boyle. TEG-1, a C. elegans homolog of human CD2BP2, functions in germline proliferation. Chris Wang, Laura Wilson- Berry, Tim Schedl, Dave Hansen.

193A This poster was moved to after presentation number 39.

PRESENTATIONS: Posters are located in Back Bay A/B/C

POSTER SESSIONS Poster board number is in bold above the title. The name of the presenting author is in bold. Full abstracts can be found online at www.mohb.org

Education and Outreach 203A Artificial chromosome fragmentation in Tetrahymena

194B thermophila: a method to study chromosome Efficacy of Enhanced Podcasts to Improve Student maintenance and replication. Ang Li, Emily Gray, Kim Learning in Genetics. Daron C. Barnard. Shampain, Eugenie Du, Alexandra Grier, Mary Flynn, Sa- kiera Hudson, Marsha Altschuler. 195A Development and implementation of an Interdisciplinary 204B Laboratory Activity Project: Determining mutation rate Characterisation of lysosomal glucocerebrosidase using Luria-Delbrück fluctuation analysis. Kirk A. mutants. Olga Amaral. Bartholomew, Suzanne M. Deschênes. 205A 196B Study of mutation impact on lysosomal proteins using Allelic Discrimination of the Human Lactase Persistence computational analyses. Olga Amaral, Ana Duarte. Trait. Ken Weinlander, Elizabeth A. De Stasio. 206B 197A Chromosome 10 duplication associated to juvenile Reinventing the Ames Test. Nathan Goodson Gregg, polyposis syndrome, histopatological diagnosis and Elizabeth A. De Stasio. clincial features. Juan M. Aparicio, Maria L. Hurtado, Roberto Vargas, Guillermo Victoria, Luis De la torre, 198B Sergio Chatelain. Building a Learning Community in Genetics. Clare A. Hasenkampf. 207A Effect of Methylparathion on Mice Bone Marrow Cells, In 199A Vivo: Micronucleus Assay. Tatiane Ornelas, Ivar Aranha. Teaching Personal Genomics to Undergraduates in an Introductory Biology Course. Nancy Kaufmann, Cristy 208B Gelling. Cutting Corners: Tricellular Junctions and the Kekkon Family. Michelle D. Arata, Joseph B. Duffy. 200B Classical and molecular mapping of C. elegans mutants in 209A an upper-level Genetics lab class. Maureen A. Peters, Natural Variation, Functional Pleiotropy and Katherine Cullen. Transcriptional Networks of Odorant Binding Protein Genes in Drosophila melanogaster. Gunjan H. Arya, 201A Allison L. Weber, Ping Wang, Michael M. Magwire, The New Genetics: Integrated Approaches for Yazmin L. Serrano Negron, Trudy F. C. Mackay, Robert R. Educational Innovation. Sara L. Tobin, A. Boughton, C. H. Anholt. Krueger, D. Weiler, MP Huxley, S. Porter, E. Johnson. 210B Other Areas of Research There is more to the Solute Carrier family 11 member1, (SLC11A1) than cytokine regulation. Agnes A. Awomoyi,

202B Susan Gauthier, Hee-Jung Kim, Mingjie Liu, Payal Metha, Determine the antimicrobial activity of phenolic Xiaokui Mo, Lianbo Yu, Sarah Tishkoff, Sushella compounds in three varieties of Iranian olive fruits Tridandanpani, Melanie Newport, Jennie Blackwell, against Candida kefir and Saccharomyces lactis. Farzaneh William LaFuse, Mark Wewers, Philippe Gros. Abdolmaleki, Mahnaz Mazaheri Asadi.

PRESENTATIONS: Posters are located in Back Bay A/B/C

POSTER SESSIONS Poster board number is in bold above the title. The name of the presenting author is in bold. Full abstracts can be found online at www.mohb.org 211A 219A The Genetic Controls of Telomere Formation in Azidothymidine (AZT) Effects in the Model Organism Drosophila melanogaster. Michelle L. Beaucher, Xiao- Eschericia coli. Deani L. Cooper, Susan T. Lovett. Feng Zheng, Yikang Rong. 220B 212B An operon containing the coiled-coil domain protein The yeast karyopherin Kap108 mediates changes in gene CCDC-55 and two E3 ubiquitin ligases is required for cell expression in response to oxidative stress. Kenneth D. migration in C. elegans. Erin J. Cram, Richard Ho. Belanger, Dmitry Tkachev, Alisandra Denton, Karyn G. Belanger. 221A Differential Epigenetic Modification of Retrotransposon- 213A Derived Genes in the Human Placenta. Erin C. Daly, Ian The chromatin modifier PRC1 collaborates with cohesion M. Morison. proteins during meiotic prophase to stabilize the synaptonemal complex and promote crossovers. Pei 222B Zhou, Sharon E. Bickel. Characterization of the gene structures and biochemical properties of the C. elegans filamin orthologs FLN-1 and 214B FLN-2. Christina R. DeMaso, Ismar Kovacevic, Erin Cram. Laminopathies and the force within: Codensin mediated chromosome compaction forces as a model for 223A understanding genome organization and gene expression Genetic characterization of the role of DNA mismatch defects. Giovanni Bosco, Christopher Bauer, Tom Hartl. repair in protecting E. coli against A:TG:C mutaons induced by sodium nitrite. Suzanne Deschênes, Kaitlyn 215A Williams. Escherichia coli G-protein ObgE mediates MreB, the prokaryotic actin homolog, to control chromosome 224B segregation. Andrea Cendrowski, Susan Lovett. The NimA related kinase, nek1, plays a role in cilia assembly, signaling, and cell cycle progression. H. Lin, A. 216B L. Kwan, S. K. Dutcher. Genomic stability of germ cells requires sister-chromatid recombination in meiosis. Raymond Chan, Jeremy Bickel, 225A Liting Chen, Jin Hayward. Heterochromatin forms a barrier to gene targeting. Sarah G. Dykstra, James E. Haber. 217A Nod, a chromokinesin-like protein is essential for meiotic 226B spindle assembly and prometaphase chromosome Genetic and genomic analysis of the negative regulation congression. Kimberly A. Collins, Katherine Hollander, R. of RNAi in C. elegans. Sylvia E. J. Fischer, Qi Pan, Chi Scott Hawley. Zhang, Taiowa Montgomery, Noah Fahlgren, James Carrington, Gary Ruvkun. 218B High throughput RNAi and small molecule screening in C. 227A elegans. Annie Conery, Jonah Larkins-Ford, Carolina Annotation Across Species: SGD and the Reference Wählby, Katherine Madden, Eyleen O'Rourke, Terence Genome Project. Dianna Fisk, Rama Balakrishnan, Karen Moy, Anne Carpenter, Frederick Ausubel, Gary Ruvkun. Christie, Maria Costanzo, Selina Dwight, Stacia Engel, Jodi Hirschman, Julie Park, Rob Nash, Cindy Krieger, Marek Skrzypek, J. Michael Cherry.

PRESENTATIONS: Posters are located in Back Bay A/B/C

POSTER SESSIONS Poster board number is in bold above the title. The name of the presenting author is in bold. Full abstracts can be found online at www.mohb.org 228B 236B Expanding the evolutionary diversity of reverse Identification and Functional Analyses of about 12,000 transcriptases. Eugene Gladyshev, Irina Arkhipova. FLJ Human cDNAs Focused on Alternative Splicing. Ai Wakamatsu, Takao Isogai. 229A Transgenic expression of matrimony (mtrm) gene 237A homologs from six Drosophila species in D. melanogaster Phosphorylation controls localization of the Drosophila pinpoints Mtrm residues critical for function during Shugoshin MEI-S332 to the centromere. Helena E. meiosis. Jennifer A. Griffiths, Sarah K. Smith, Youbin Kashevsky, Cristina Nogueira, Astrid Clarke, Terry Orr- Xiang, R. Scott Hawley. Weaver.

230B 238B Swapping Stories of Kekkon5: From Signaling to Adherens Spt6 is required for heterochromatin formation in fission Junctions. Harita Haridas, Christina Ernst. yeast. Christine Kiely, Samuel Marguerat, Jürg Bähler, Fred Winston. 231A Reactome Pathway Database: Model Organisms to 239A Human Biology. Robin Haw, Michael Caudy, David Croft, A novel gene regulating the level of phosphorylated Akt Phani Garapati, Marc Gillespie, Bijay Jassal, Steven Jupe, and total Akt in Drosophila melanogaster. Heuijong Kim, Shahana Mahajan, Lisa Matthews, Bruce May, Gavin Kiyoung Kim, Jaekwang Kim, Jeongbin Yim. O'Kelly, Esther Schmidt, Veronica Shamovsky, Guanming Wu, Ewan Birney, Henning Hermjakob, Peter 240B D'Eustachio, Lincoln Stein. Checking out of the Roach Motel: How Filamin Controls Spermatheca-Uterine Valve Dilation in C. elegans. Ismar 232B Kovacevic, Erin Cram. microRNAs Reveal the Nature of the Ancestral Vertebrate. Alysha M. Heimberg, Philip C. J. Donoghue, 241A Kevin J. Peterson. Proteolytic processing of BMP type proteins in signaling regulation. Jaana Künnapuu, Osamu Shimmi. 233A New insights into the SAGA coactivator complex from 242B studies in the fission yeast Schizosaccharomyces pombe. Role of the CACN-1/MIG-5 interaction during distal tip Dominique Helmlinger, Judit Villén, Samuel Marguerat, cell migration. Melissa LaBonty, Mouna Ibourk, Erin Jürg Bähler, Steven P. Gygi, Fred Winston. Cram.

234B 243A Drosophila shrub regulates the endosomal trafficking and FHA domain of Fkh1 bound to the Recombination activation of Notch. Kazuya Hori, Anindya Sen, Elodie Enhancer regulates donor preference by physically Pauwels, Spyros Artavanis-Tsakonas. interacting with MAT region in Saccharomyces cerevisiae. Jin Li, Eric Coïc, James E. Haber. 235A tRNA Cellular Distribution is Coordinated with Translation 244B and P-body Formation Pathways. Rebecca L. Hurto, Anita Analysis of cell fate from single-cell gene expression K. Hopper. profiles in C. elegans. Xiao Liu, Sarah Aerni, Fuhui Long, Hanchuan Peng, Min Jiang, Adolfo Sánchez-Blanco, John Murray, Elicia Preston, Barbara Mericle, Eugene Myers, Serafim Batzoglou, Stuart Kim.

PRESENTATIONS: Posters are located in Back Bay A/B/C

POSTER SESSIONS Poster board number is in bold above the title. The name of the presenting author is in bold. Full abstracts can be found online at www.mohb.org 245A 253A Systematic Analysis of Reproductive Aging Regulation by Regulation of DNA replication and fork progression. Jared TGF- Signaling in C. elegans. Shijing Luo, Gunnar Nordman, Giovanni Bosco, Eugenia Park, Terry Orr- Kleemann, Wendy Shaw, Jasmine Ashraf, Coleen Weaver. Murphy. 254B 246B A Genetic Screen to Establish C. elegans Ovulation as a Life History of Drosophila melanogaster selected for Model for Studying Mechanosensation. Jose Orozco, resistance to Gram-Positive Human Pathogen Bacillus Ismar Kovacevic, Erin Cram. cereus. Junjie Ma, Deidra Jacobsen, Zhen Hu, Lawrence Harshman, Andrew Benson. 255A The JNK pathway interacts with Drosophila BMP signaling 247A in the formation of the adult head. Sung-Yeon Park, Uncovering the genetic architecture of male pair bonding Brian Stultz, Deborah Hursh. behavior in the prairie vole (Microtus ochrogaster). Lisa A. McGraw, Jamie K. Davis, Josh J. Lowman, Boudewijn 256B FH ten Hallers, Maxim Koriabine, Pieter J. de Jong, Ribonuclease H2 contributes to the maintenance of Timothy D. Read, M. Katherine Rudd, Larry J. Young, genome stability. Catherine Potenski, Hannah Klein. James W. Thomas, NIH Intramural Sequencing Center. 257A 248B Elevated O-GlcNAc modification can extend Activation of autophagy during cell death requires the Caenorhabditis elegans lifespan. Mohammad M. engulfment receptor Draper. Christina K. McPhee, Mary Rahman, Olga Stuchlik, Enas Karim, Lance Wells, Edward A. Logan, Marc R. Freeman, Eric H. Baehrecke. Kipreos.

249A 258B Mutational and yeast two-hybrid analysis of the C. Highthroughput microfluidics and ultrafast optics for elegans winged-helix transcription factor LIN-31 reveal whole-organism (C. elegans) screening. Christopher functionally-distinct domains. Leilani M. Miller. Rohde, Chrysanthi Samara, Cody Gilleland, Mehmet Fatih Yanik. 250B Epigenetic Inheritance of Silencing at Mating -type loci in 259A Budding Yeast. Tina Motwani. Reconstitution of human RNA interference in budding yeast. Kyoungho Suk, Jihye Choi, Yo Suzuki, Sedide B. 251A Öztürk, Joseph C. Mellor, Koon Ho Wong, Richard I. A cellular resolution atlas of embryonic gene expression Gregory, Frederick P. Roth. dynamics in C. elegans. John I. Murray, Thomas Boyle, Elicia Preston, Dionne Vafeados, Zhirong Bao, Robert 260B Waterston, ModENCODE TF Binding Site Group. P75NTR isoform expression and hypothyroid modulation in postnatal murine brain and striated muscle. Mohamed 252B A. Sabry, Mariam Al-Ramadan, Ahmed Baqer. The Control of Lipid Metabolism by Splicing in Drosophila. Alexis Nagengast, Timothy Rudolph, Thomas Carr, Justin DiAngelo.

PRESENTATIONS: Posters are located in Back Bay A/B/C

POSTER SESSIONS Poster board number is in bold above the title. The name of the presenting author is in bold. Full abstracts can be found online at www.mohb.org 261A 269A Experimental Evolution of Retrotransposon Overdose An optimized short hairpin microRNA library to examine Strains of Saccharomyces cerevisiae. Lisa Z. Scheifele, early embryonic development in Drosophila. Richelle L. James DiCarlo, Jef D. Boeke. Sopko, Jianquan Ni, Laura Holderbaum, Donghui Yang- Zhou, Lu-Ping Liu, Matt Booker, Fiona McAllister, Liz 262B Perkins, Steven Gygi, Norbert Perrimon. A set of E. coli Chromosomal lacZ mutants which allow detection of specific mutations including frameshifts, 270B base substitutions, deletions or template-switch Evaluation of RET Transcription Modulation by Estrogen mutations. Tracey A. Seier, Dana Padgett, Vincent A. in vitro and in vivo. Zachary E. Stine, David M. Sutera, Susan T. Lovett. McGaughey, Samantha Maragh, Leila Taher, Ivan Ovcharenko, Andrew S. McCallion. 263A H2A.Z (Htz1) controls the cell-cycle dependent 271A establishment of transcriptional silencing at yeast Calcineurin and its regulation by Sra/RCAN in completion telomeres. Upasna Sharma, Kristen Martins-Taylor, Scott of meiosis in Drosophila females. Satomi Takeo, Selene G. Holmes. Swanson, Laurence Florens, Michael Washburn, Toshiro Aigaki, Scott Hawley. 264B LIM-domain protein TRIP6 associates with shelterin to 272B mediate telomere protection. Samantha A. Sheppard, Protocol-dependent biases in RNA Seq: Optimization for Diego Loayza. quantification and novel RNA discovery. John F. Thompson, Philip Kapranov, Tal Raz, Doron Lipson, Stan 265A Letovsky, Patrice Milos. Unique intronic sequences affect RNA processing of spinal muscular atrophy gene. Natalia Singh, Katrin 273A Hollinger, Dhruva Bhattacharya, Ravindra Singh. The RGMb/DRAGON homolog DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis 266B elegans. Chenxi Tian, Debjeet Sen, Herong Shi, Marisa A unique intronic motif for gene correction in spinal Foehr, Yevgeniy Plavskin, Jun Liu. muscular atrophy. Natalia N. Singh, Joonbae Seo, Maria Shishimorova, Lu Cheng Cao, Laxman Gangwani, 274B Ravindra N. Singh. -arrestin Kurtz inhibits MAPK and Toll signaling in Drosophila development. Marla Tipping, Yoosik Kim, 267A Stanislav Shvartsman, Alexey Veraksa. An evolutionarily conserved motif in the GCK-family kinase Sps1p is required for function during sporulation. 275A Christian J. Slubowski, Victoria Cabot, Thomas Clausen, Calcineurin homologous protein is required for a proton- Christina Wong, Odile Kamanzi, Nilsa Vale, Linda Huang. activated muscle contraction in Caenorhabditis elegans. Jamie Wagner, Ashley Taylor, Kiri Ulmschneider, Bryne 268B Ulmschneider, Keith Nehrke, Maureen Peters. Examining the Mtrm-Polo interaction in vivo. Sarah K. Smith, Jennifer A. Griffiths, Youbin Xiang, R. Scott 276B Hawley. Neurobehavioral traits in mice are particularly susceptible to genome structural changes: implications for human neuropsychiatric disease. Katherina Walz, Jessica Molina, Guénola Ricard, Juan I. Young, Wenli Gu, James R. Lupski, Alexandre Reymond.

PRESENTATIONS: Posters are located in Back Bay A/B/C

POSTER SESSIONS Poster board number is in bold above the title. The name of the presenting author is in bold. Full abstracts can be found online at www.mohb.org 277A 282B Calling Cards for DNA Binding Proteins. Haoyi Wang, DNA Polymerase Theta Contributes to Lig4-Independent David Mayhew, Xuhua Chen, Mark Johnston, Robi Mitra. Repair Of DNA Double Strand Breaks By Synthesis- Dependent Microhomology-Mediated End Joining. Amy 278B Marie Yu, Mitch McVey. Regulation of Cortex, an APC/C activator essential for the female Drosophila meiotic cell cycle. Zachary J. 283A Whitfield, Jillian Pesin, Chin-Chin Yao, Terry Orr-Weaver. Evolution in twenty years or less: rapid selection on standing genetic variants underlies major morphological 279A and physiological change in threespine sticklebacks. Haili Conserved cytoplasmic polyA polymerases regulate Zhang, Mike Bell, David Kingsley. gametogenesis in Drosophila. Jun Cui, Caroline V. Sartain, Mariana F. Wolfner. 284B Crosstalk between the Small RNA Pathways in 280B Drosophila. Rui Zhou, Benjamin Czech, Ikuko Hotta, Leah The TRiP: The Transgenic RNAi Project at Harvard Sabin, Julius Brennecke, Ahmet M. Denli, Yaniv Erlich, Medical School. Laura Holderbaum, Donghui Yang-Zhou, Richard Binari, Christians Villalta, Assaf Gordon, Pengyu Jian-quan Ni, Luping Liu, Norbert Perrimon, Lizabeth Hong, Sara Cherry, Greg Hannon, Norbert Perrimon. Perkins. 285A 281A Phenotypic plasticity of gene expression in Drosophila Non-canonical transcripts in yeast surveyed using 3'-end melanogaster . Shanshan Zhou, Eric Stone, Trudy next-generation sequencing. Oh Kyu Yoon, Rachel Brem. Mackay, Robert Anholt.

PRESENTATIONS: Posters are located in Back Bay A/B/C

SPEAKER AND AUTHOR INDEX This index includes names in alphabetical order of all invited authors, and co-authors published in this book. The number following a name refers to the abstract’s program number. An asterisk denotes a presenting author. Platform presentations: 1-54, Poster presentations: 55A-285A.

A Balakrishnan, Rama, 227A Boyle, Jon, 163A, 184B Abdolmaleki, Farzaneh, 202B* Bannon, Desmond I., 153A Boyle, Thomas, 251A Abe, Hiroaki, 148B Bao, Yun, 57A Bradley, Allan, 170B Abraham, Nessy, 191A Bao, Zhirong, 251A Braus, Gerhard, 118B Abrams, John, 146B Baqer, Ahmed, 260B Breitenstein, Alexander, 70B Adams, David, 170B Barnard, Daron C., 194B* Brem, Rachel, 281A Adarichev, Vyacheslav A., 69A* Barrett, Irene, 16 Brennecke, Julius, 284B Adman, Elinor, 119A Barstead, Robert J., 168B Breslow, Jan L., 116B Aerni, Sarah, 244B Bartelt, Diana, 162B Broad Institute Sequencing Platform, 53, Agam, Avigail, 170B Bartholomew, Kirk A., 195A* 169A Ai, Junmei, 147A Basu, Sukanya, 186B* Brockman, Christoph, 17 Aigaki, Toshiro, 271A Batzoglou, Serafim, 244B Brodsky, Jeffrey L., 89A Ajimura, Masahiro, 148B Bauer, Christopher, 214B Broekelmann, Thomas, 103A Akhmedov, Alexander, 70B* Baumann, Douglas D., 123A Brown, Steve, 170B Albrecht, Kenneth H., 142B Baxter-King, Gavin, 152B Brown, Tricia, 144B Alfoldi, Jessica, 53 Baylies, Mary K., 187A Brugmann, Samantha, 40 Alföldi, Jessica E., 169A Beach, Adam, 131A, 132B Brul, Stanley, 80B Allen, Jared A., 123A Beachy, Phil, 22 Brumby, Tony, 135A Al-Ramadan, Mariam, 260B Beal, Jon S., 101A Brzoska, Pius, 57A Altschuler, Marsha, 203A* Beaucher, Michelle L., 211A* Buchberg, Arthur M., 113A Altshuler, David M., 1* Beckwith, J., 122B Buda, Alexandra M., 174B Alvarez, Carlos E., 71A* Beier, David, 45 Burdette, Alexander, 76B* Amaral, Olga, 55A*, 204B*, 205A* Belanger, Karyn G., 212B Burghoorn, Jan, 180B Amon, Angelika, 24 Belanger, Kenneth D., 212B* Burstein, Michelle, 131A, 132B Amos-Landgraf, James, 72B* Bell, Mike, 283A Bustamante, Carlos D., 5* Anderson, Kathryn V., 19* Bello, Susan M., 101A Andreassi, Megan, 152B Beltran Agulló, Sergi, 135A C Anholt, Robert, 285A Ben-Aroya, Shay, 16 Cabernard, Clemens, 193A Anholt, Robert R. H., 138B, 209A Bennett, Joan, 97A Cabot, Victoria, 267A Anjum, Saima Ghafoor, 185A* Benson, Andrew, 246B Calder, R. Brent, 62B Antoshechkin, Igor, 179A Berg, Dan, 143A Caldwell, G. A., 30, 100B Aparicio, Juan M., 206B* Berg, Jeremy, Keynote Address Caldwell, Guy, 76B Apidianakis, Yiorgos, 64B Berg, Kyra, 152B Caldwell, Guy A., 99A, 134B Apponi, Luciano, 17 Bergmann, Andreas, 20* Caldwell, K. A., 30, 100B Aranha, Ivar, 207A* Berkowitz, Laura A., 134B Caldwell, Kim, 76B Arata, Michelle D., 208B* Bernard, Pascal, 145A Caldwell, Kim A., 99A, 134B Argentaro, A., 10 Bhadra, Utpal, 73A* Callan, Matthew A., 193A Arkhipova, Irina, 228B Bhattacharya, Dhruva, 265A Campbell, A. Malcolm, Education and Artavanis-Tsakonas, Spyros, 47, 60B, 171A, Bickel, Jeremy, 216B Outreach Workshop 186B, 234B Bickel, Sharon E., 213A* Campbell, Megan, 26 Arya, Gunjan H., 209A* Billingsley, Cherie N., 123A Campbell, Terry G., 138B Ashraf, Jasmine, 245A Binari, Richard, 141A, 284B Candeias, Rogerio, 171A Atwell, Susanna, 183A Birney, Ewan, 170B, 231A Cao, Cheng J., 153A* Ausubel, Frederick, 218B Blackwell, Jennie, 210B Cao, Lu Cheng, 266B Awomoyi, Agnes A., 210B* Blank, Robert D., 74B* Carlson, Joseph, 171A Aylor, David, 175A Blazek, Joshua D., 75A*, 123A Carpenter, Anne, 218B Ayroles, Julien F., 4 Blue, Marketta, 147A Carr, Thomas, 252B Blummenstiel, Justin, 172B Carrington, James, 226B Boeke, Jef D., 261A B Casanovas, Guillem, 77A* Boettiger, Alistair N., 166B* Babiuk, Randy, 101A Casu, Carla, 107A Bolden, Jessica, 135A Babu K., Suresh, 73A Caudy, Michael, 231A Booker, Matt, 269A Baehrecke, Eric H., 248B Cavaliere, Daniela, 81A Borén, Jan, 70B Bagheri-Fam, S., 10 Celniker, Susan, 171A Borom, A. R., 100B Bähler, Jürg, 233A, 238B Cendrowski, Andrea, 215A* Borowsky, Mark, 182B Bailey, Alexis, 37 Chan, Alina, 16 Bosco, Giovanni, 214B*, 253A Bajguz, Dominika A., 173A Chan, Christina, 88B Boughton, A., 201A Bajpai, Ruchi, 40 Chan, Frank, 53 Bourque, Simon, 131A, 132B 37 SPEAKER AND AUTHOR INDEX This index includes names in alphabetical order of all invited authors, and co-authors published in this book. The number following a name refers to the abstract’s program number. An asterisk denotes a presenting author. Platform presentations: 1-54, Poster presentations: 55A-285A.

Chan, Raymond, 216B* D Dujon, Bernard A., 54* Chang, Chia-Jung, 105A Daigle, Joseph G., 79A* Durbin, Richard, 170B Chang, Samuel, 152B Daldine, Christopher, 144B Dutcher, S. K., 224B* Chapo, Joseph, 146B Daley, George, 38* Dwight, Selina, 227A Chatelain, Sergio, 206B Daly, Erin C., 221A* Dykstra, Sarah G., 225A* Chaudhry, Iasha, 168B Daly, Mark, 182B Chen, Caifu, 57A* Danecek, Petr, 170B E Chen, Ci, 85A Daniels, Karla, 165A Ecker, Joseph R., 50* Chen, Liting, 216B Daniels, Karla J., 33 Edgley, Mark L., 168B* Chen, Pan, 76B Darrah, Andrew, 123A Edwards, Gaylen, 42 Chen, Rui, 4 Davis, Jamie, 42 Engel, Stacia, 227A Chen, Xiao, 171A Davis, Jamie K., 247A Eppig, Janan T., 101A Chen, Xuhua, 277A de Boer, Richard, 80B* Erlich, Yaniv, 284B Chen, Yuan-Tsong, 105A de Coo, René, 136B Ernst, Carl, 182B Chen-Quin, E. B., 58B* Deitz, Samantha, 75A Ernst, Christina, 230B Cherry, J. Michael, 227A de Jong, Pieter J., 247A Evans, Leah R., 61A Cherry, Sara, 284B De la torre, Luis, 206B Ewald, Collin, 86B* Chesler, Elissa, 175A DeLeon, S. M., 100B Chikaraishi, Dona M., 114B Delvy, Roberta N., 174B F Chin, Randal, 91A Demant, Peter, 74B Fahlgren, Noah, 226B Chisholm, Karen M., 119A DeMaso, Christina R., 222B* Fellmann, Christof, 125A Cho, Chan Young, 78B* Dene, Howard, 101A Ferguson, Cole, 110B Cho, Julie Y., 154B* Deng, Youping, 147A Fink, Gerald R., 31* Cho, Julio, 18 Denli, Ahmet M., 284B Fischer, Karin, 115A Choi, Jihye, 259A Denton, Alisandra, 212B Fischer, Sylvia E. J., 226B* Choi, Sang-Yun, 78B, 159A DeRisi, Joe, 36 Fisk, Dianna, 227A* Chou, Mang-Ting, 156B Deschênes, Suzanne, 223A* Fleming, John, 191A Christie, Karen, 227A Deschênes, Suzanne M., 195A Flibotte, Stephane, 168B Chu, D., 140B De Stasio, Elizabeth A., 143A*, 196B*, 197A* Flint, Jonathan, 170B Chuang, Jeffrey H., 167A* D'Eustachio, Peter, 231A Florens, Laurence, 271A Churchill, Gary, 175A DiAngelo, Justin, 252B Flynn, Mary, 203A Churchill, Perry, 76B DiCarlo, James, 261A Foehr, Marisa, 273A Ciliberto, Christopher, 103A Dietz, H. C., 84B Forthofer, Kim L., 101A Cintra, T., 140B Diggins, Lenard, 129A Fox, Paul, 41* Clarke, Astrid, 237A Digilio, Filomena Anna, 81A* Frank, Philippe G., 116B Clarke, Catherine, 91A Dillman, Adler, 179A Freeman, Kimberly, 42 Clarke, Geraldine, 6* Dimlich, Douglas, 47 Freeman, Marc R., 248B Clausen, Thomas, 267A di Palma, Federica, 169A Freudenreich, Catherine H., 87A* Clement, Mark, 123A Di Palma, Federica, 53, 181A Friederichs, Jennifer M., 23 Cohen-Fix, Orna, 23 DiStefano, Ginnene, 82B* Fukumura, Ryutaro, 92B Coïc, Eric, 243A Dobi, Krista C., 187A* Fuller, Margaret, 37 Collins, Kimberly A., 217A* Doe, Chris Q., 193A

Conery, Annie, 218B* Doerge, R. W., 123A Conway, Simon J., 114B Doerries, Carola, 70B G Cooper, Deani L., 219A* Doimo, Mara, 83A* Gaddy, Anna, 75A Corbett, Anita H., 17* Donahue, L., 122B Galluzzo, Maria A., 173A Corona, Jasmine, 61A Dong, Ke, 158B Gambaro, Karen, 67A Correa, Stephanie M., 142B* Donoghue, Philip C. J., 232B Gan, Xinagchao, 170B Costanzo, Maria, 227A Donohue, Leah Rae, 170B Ganetzky, Barry S., 26* Cram, Erin, 190B, 222B, 240B, 242B, 254B Dove, William, 72B Gangwani, Laxman, 266B Cram, Erin J., 220B* Doyle, J. J., 84B* Garapati, Phani, 231A Crobu, Francesca, 107A Dranginis, Anne, 162B Garashabi, Masoud, 17 Croft, David, 231A Draper, Isabelle, 85A* Garcia, Ana Maria, 62B Cui, Jun, 279A Du, Eugenie, 203A Gauthier, Susan, 210B Cullen, Katherine, 200B Duarte, Ana, 55A, 205A Gaval-Cruz, Meriem, 42 Curtin, Kathryn D., 59A* Duffy, Joseph B., 208B Geekiyanage, Hirosha, 88B* Czech, Benjamin, 284B Dujon, Bernard, 177A Gelling, Cristy, 199A Gelling, Cristy L., 89A* 38 SPEAKER AND AUTHOR INDEX This index includes names in alphabetical order of all invited authors, and co-authors published in this book. The number following a name refers to the abstract’s program number. An asterisk denotes a presenting author. Platform presentations: 1-54, Poster presentations: 55A-285A.

George, Aleah M., 174B Harley, Vincent R., 145A* I G. Holmes, Scott, 263A Harman, Brady, 75A Ibourk, Mouna, 242B Ghosh, Salil, 111A Harpaz, Nofar, 94B* Imam, Farhad B., 96B* Ghosh, Suman, 23 Harrington, A. J., 30* Inamadar, Arati, 79A Giacomotto, Jean, 90B* Harshman, Lawrence, 246B Inamdar, Arati A., 97A* Gibbs, Richard, 4 Hart, Anne, 47 Inoko, Hidetoshi, 178B Gilleland, Cody, 258B Hartl, Tom, 214B Insco, Megan, 37 Gillespie, Marc, 231A Hartman, Cory, 72B Irving, Amy, 72B Giordano, Ennio, 81A Hasenkampf, Clare A., 198B* Isogai, Takao, 236B* Gladyshev, Eugene, 228B* Haw, Robin, 231A* Glebova, Anastasia, 131A, 132B Hawley, R. Scott, 172B, 217A, 229A, 268B J Go, A., 140B Hawley, Scott, 271A Jackson, Ian, 170B Gobel, Verena, 191A Hayward, Jin, 216B Jackson, Walker S., 98B* Goldberg, Alexander, 131A, 132B Heatherly, Jessica M., 27 Jacobs, Roger, 137A Gomez, Fernando, 91A* Hedgecock, Edward, 189A Jacobsen, Deidra, 246B Gondo, Yoichi, 92B* Heffner, C., 122B Jain, Charu, 160B* Gong, Yaoqin, 155A* Heilbut, Adrian, 182B Jang, Jennifer, 156B Goodson, Martin, 170B Heimberg, Alysha M., 232B* Jao, M., 140B Goodson Gregg, Nathan, 197A Helmlinger, Dominique, 233A* Jasmin, Jean-François, 116B Gordon, Assaf, 284B Hemmingsson, Oskar, 95A* Jaspersen, Sue L., 23* Gorsich, Steven W., 144B* Hengartner, Michael, 125A Jassal, Bijay, 231A Goulding, Karen, 135A Henske, Elizabeth, 112B Ji, Jiafu, 68B Grabherr, Manfred, 53, 169A Hermjakob, Henning, 231A Jia, Shuqin, 68B Gray, Emily, 203A Herrman, Sandra, 102B Jiang, Min, 244B Gregory, Richard I., 259A Hicks, Matthew L., 99A Johnson, E., 201A Greider, Carol, Keynote Address Hieter, Philip A., 16* Johnson, Jeremy, 53 Grier, Alexandra, 203A Hines, Melissa, 12* Johnson, Jeremy W., 169A* Griffiths, Jennifer A., 229A*, 268B Hirschman, Jodi, 227A Johnson, Mark S., 153A Gros, Philippe, 210B Hisamoto, Naoki, 164B Johnston, Mark, 277A Grunwald, David, 48* Ho, Diana, 60B Jones, Elizabeth, 138B Gu, Wenli, 276B Ho, Richard, 220B Jones, Felicity, 53 Gunther, Derrick, 48 Hofbauer, Harald, 102B Jorgensen, Erik, 25 Guo, Su, 167A Holderbaum, Laura, 269A, 280B Juneau, Mylene, 131A, 132B Guo, Z. Sheng, 149A Hollander, Katherine, 217A Jupe, Steven, 231A Gusella, James, 182B Hollinger, Katrin, 265A Jurynec, Michael, 48 Guthrie, Chris R., 106B Hong, Pengyu, 284B Gygi, Steven, 171A, 269A Hopper, Anita K., 235A Gygi, Steven P., 233A Hori, Kazuya, 186B, 234B* K Hoskins, Sally, Education and Outreach Kadin, James A., 101A H Workshop Kahlon, Ravi S., 142B Kamanzi, Odile, 164B, 267A Haber, James E., 225A, 243A Hotta, Ikuko, 284B Kamau, Edwin, 163A Haddad, Gabriel, 124B Hu, Zhen, 246B Kamida, A., 126B Hadi, Richard, 156B Huang, Brenda, 17 Kane, Daniel, 66B Hajeri, Vinita, 63A Huang, Brian, 156B Kankel, Mark William, 47 Hamamichi, S., 100B Huang, Guanghua, 33 Kao, Gautam, 95A Hamamichi, Shusei, 134B Huang, Linda, 267A Kapadia, Bhaveen, 171A Han, In Kyu, 74B Huang, Yu S., 183A Kapranov, Philip, 272B Han, Yi, 4 Hudson, Sa-kiera, 203A Karim, Enas, 257A Hannon, Greg, 284B Huggins, Gordon, 85A Karlsson, Elinor K., 108B Hanover, John A., 111A Hui, Carrie, 66B Karun, Singh, 28 Hanscom, Carrie, 182B Hunter, Anthony, 72B Kashevsky, Helena E., 237A* Hansen, Dave, 192B Hunter, Jerrod W., 27 Katiyar, Sanjay, 116B Hanson, Pamela K., 93A* Hursh, Deborah, 255A Katsanis, Nicholas, 43* Harbison, Susan T., 4* Hurtado, Maria L., 206B Katsumura, Takafumi, 56B* Hare, Lauren, 145A Hurto, Rebecca L., 235A* Kaufmann, Nancy, 199A* Haridas, Harita, 230B* Huxley, MP, 201A Kautu, Bwarenaba B., 99A* Harley, V., 10 Hwang, Hye-Min, 159A* Kawamura, Shoji, 56B 39 SPEAKER AND AUTHOR INDEX This index includes names in alphabetical order of all invited authors, and co-authors published in this book. The number following a name refers to the abstract’s program number. An asterisk denotes a presenting author. Platform presentations: 1-54, Poster presentations: 55A-285A.

Keane, Thomas M., 170B* L Long, Fuhui, 244B Keebaugh, Alaine, 42* LaBonty, Melissa, 242B* Love, Dona C., 111A Kelley, Richard, 151A LaChance, Lauren J., 173A Lovett, Susan, 215A Kellis, Manolis, 171A Ladage, Mary, 63A Lovett, Susan T., 219A, 262B Kelly, Seth M., 17 LaFuse, William, 210B Lowe, Scott, 125A Kennedy, Trudy, 145A Lander, Eric S., 169A Lowman, Josh J., 247A Khan, George F., 138B Landmesser, Ulf, 70B Lu, Wan-Jin, 146B* Khan, Liakot, 191A Landry, Benjamin, 160B Ludbrook, L., 10 Kiely, Christine, 238B* Langley, Charles H., 3* Luescher, Thomas F., 70B Kim, Dennis H., 35, 120B, 164B LaRiviere, Jenna R., 174B Lundell, Martha, 62B Kim, Hee-Jung, 210B Larkins-Ford, Jonah, 218B Luo, Ningguang, 158B Kim, Heuijong, 239A* Larsen, Pamela L., 157A Luo, Shijing, 245A* Kim, Hyun Joo, 78B Lawal, Hakeem O., 156B* Luois, Samantha, 193A Kim, Jaekwang, 239A Le, Viet, 104B* Lupski, James R., 276B Kim, Jeong-Hyun, 161A* Lee, Katherine J., 173A Lutz, C., 122B Kim, Kiyoung, 239A Lee, Sean, 117A Lynch, Eric, 119A Kim, Stuart, 52*, 244B Lee, Shin-Hee, 159A Kim, Yoosik, 274B Lee, S. K., 100B M Kim, Youngjo, 189A Lee, S. Kyle, 99A Ma, Junjie, 246B* Kimura, Tetsuaki, 178B Lee, Sungsu, 162B* Maciel, Patrícia, 130B King, Mary-Claire, 119A Lee, Teresa, 139A Mackay, Trudy, 285A Kingsley, David, 53, 283A Lee, Yi-Ching, 105A* Mackay, Trudy F. C., 4, 138B, 209A Kipreos, Edward, 189A, 257A Lenk, Guy, 110B Madden, Katherine, 218B Kirby, Andrew, 182B Letovsky, Stan, 272B Magwire, Michael M., 209A Kleemann, Gunnar, 245A Leung, Sara, 17 Mahajan, Shahana, 231A Klein, Hannah, 256B Levine, Michael, 166B Mahoney, Matt B., 129A Knight, A. L., 100B* Lewis, Jill, 101A Maine, Eleanor, 41 Knittelfelder, Oskar, 102B Li, Ang, 203A Makino, Shigeru, 92B Knowlton, Michelle N., 101A* Li, Chaohua, 68B Manchinu, Maria F., 107A* Knutsen, Russell H., 103A Li, Chris, 86B Mantis, John, 188B Kofoed, Megan, 16 Li, Jin, 243A* Mao, Fei, 155A Kohler, Ines, 125A Li, Qiang, 167A Mao, Jinghe, 147A* Kohlwein, Sepp D., 102B* Li, Weiqing, 119A Mao, Yingwei, 28 Kolodner, Richard, 21 Li, Xiaoming, 65A Maragh, Samantha, 270B Kooistra, Tristan, 120B, 164B Liachko, Nicole F., 106B* Marenda, Daniel, 82B Koratkar, Revati, 113A Liepkalns, Justine, 62B Marguerat, Samuel, 233A, 238B Koriabine, Maxim, 247A Lifton, Rick, 14 Markstein, Michele, 18* Korostyshevsky, Daniel, 117A Lin, H., 224B Marongiu, Maria F., 107A Kostka, Dennis, 167A Lin, Na, 139A Martin Blanco, Enrique, 135A Koura, Minako, 128B Lindblad-Toh, Kerstin, 53, 108B, 169A, 181A Martinez, Endry, 66B Kovacevic, Ismar, 222B, 240B*, 254B Lindquist, Susan, 13*, 98B Martins-Taylor, Kristen, 263A Kozel, Beth A., 103A* Lipson, Doron, 272B Masurekar, Prakash, 97A Kraemer, Brian C., 106B Lisanti, Michael P., 116B Mataga, Megan A., 61A* Krantz, David E., 156B Litscher, Suzanne J., 74B Matsuda, Junichiro, 128B Krause, Michael W., 111A Liu, Jun, 273A Matsumoto, Kunihiro, 164B Krieger, Cindy, 227A Liu, Lu-Ping, 269A Matter, Christian M., 70B Krishnan, Anita, 73A Liu, Luping, 280B Matthews, Lisa, 231A Krueger, C., 201A Liu, Mingjie, 210B Mauceli, Evan, 53, 108B*, 169A Kruglyak, Leonid, 2* Liu, Xiao, 244B* Mawhinney, Rebecca M. S., 109A* Kshetrapal, Pallavi, 60B* Liu, Zhiqi, 158B May, Bruce, 231A Kumar Tiwari, Ashok, 73A Loayza, Diego, 264B Mayhew, David, 277A Kumiko, Kato, 126B Locke, Cody J., 99A Mazaheri Asadi, Mahnaz, 202B Künnapuu, Jaana, 241A* Loew, Jenny E., 61A McAllister, Fiona, 269A Kuss, Andreas, 17 Logan, Mary A., 248B McCallion, Andrew S., 270B Kuthethur, Guruharsha, 47, 171A* Loh, Y. H. Eddie, 181A McCoy, Lenovia, 138B Kwan, A. L., 224B Lohmann, Christine, 70B McGaughey, David M., 270B Kyryakov, Pavlo, 131A, 132B Loken, Tiffany, 61A McGraw, Lisa A., 247A* 40 SPEAKER AND AUTHOR INDEX This index includes names in alphabetical order of all invited authors, and co-authors published in this book. The number following a name refers to the abstract’s program number. An asterisk denotes a presenting author. Platform presentations: 1-54, Poster presentations: 55A-285A.

McLellan, Jessica, 16 N Park, Byung-Lae, 161A McManus, Kirk, 16 Nagaraju, Javaregowda, 148B* Park, Choon-Sik, 161A McMillan, Leonard, 175A Nagengast, Alexis, 252B* Park, Eugenia, 253A McPhee, Christina K., 248B* Nallaseth, Ferez S., 149A* Park, Julie, 227A McPherson, Alexandria R., 174B Naredi, Peter, 95A Park, Sang Won, 78B McVey, Mitch, 62B*, 66B, 282B Naruse, Kiyoshi, 178B Park, Sung-Yeon, 255A* Mecham, Robert P., 103A Nash, Rob, 227A Pastor, Kelly, 160B Meehan, Tracy L., 163A* Negron, Yazmin L. Serrano, 209A Patricia, Pukkila, Education and Outreach Meidenbauer, Joshua, 188B* Nehrke, Keith, 275A Workshop Meisler, Miriam H., 110B* Neuman, Nicole A., 112B* Pauwels, Elodie, 234B Mekalanos, John, 34 Newbauer, Abby, 123A Pavlides, Stephanos, 116B* Mellor, Joseph C., 259A Newport, Melanie, 210B Peng, Hanchuan, 244B Mercier, Isabelle, 116B Ni, Jian-quan, 280B Perera, Anoja, 172B Mericle, Barbara, 244B Ni, Jianquan, 269A Perkins, Liz, 269A Mes-Masson, Anne-Marie, 67A NIH Intramural Sequencing Center, 247A Perkins, Lizabeth, 280B Metha, Payal, 210B Niu, Deyun, 68B Perlstein, Ethan O., 117A* Meurs, Kate, 108B Nnadi, Stephanie C., 113A* Perrimon, Norbert, 18, 64B, 141A, 269A, Meyer, Barbara J., 7* Noguchi, Yoko, 128B 280B, 284B Miller, Danny, 172B* Nogueira, Cristina, 237A Perry, Kalen P., 99A Miller, Darla, 175A Noll, Aaron, 172B Perry, Michael, 166B Miller, Leilani M., 249A* Nordborg, Magnus, 176B, 183A Pesin, Jillian, 278B Milos, Patrice, 272B Nordman, Jared, 253A* Pestell, Richard G., 116B Minaker, Sean, 16 Noto, John, 17 Peters, Maureen, 275A Mintseris, Julian, 171A Peters, Maureen A., 200B* Mirsoian, S., 140B O Peterson, Kevin J., 232B Mita, Kazuei, 148B Petroi, Doris, 118B* Obar, Robert, 171A Mitani, Hiroshi, 56B Petschnigg, Julia, 102B Oda, Shoji, 56B Mitchell, Heather, 42 Piasecki, Brian P., 180B O'Donnell, Janis, 79A Mitra, Robi, 277A Pierce, Sarah B., 119A* Ohsumi, Toshiro, 182B Mo, Xiaokui, 210B Pinto, Eugenia, 55A O'Kelly, Gavin, 231A Moberg, Kenneth, 17 Pitsouli, Chrysoula, 64B* Olaopa, Michael, 114B* Mocharla, Pavani, 70B Platt, Alexander, 176B*, 183A Oliveira, Pedro, 55A ModENCODE TF Binding Site Group, 251A Plavskin, Yevgeniy, 273A Olson, Eric N., 15* Moerman, Donald G., 168B Poddie, Daniela, 107A Omoruyi, I., 140B Molina, Jessica, 276B Pollard, Katherine S., 167A O’Neil, Phil, 129A Mondoux, Michelle A., 111A* Ponting, Chris, 170B Oota, Hiroki, 56B Montgomery, Taiowa, 226B Porcu, Susanna, 107A Ornelas, Tatiane, 207A Morimoto, Rick, 130B Porter, S., 201A O'Rourke, Eyleen, 218B Morison, Ian M., 221A Potenski, Catherine, 256B* Orozco, Jose, 254B* Morris, Andrew, 6 Pourquie, Olivier, 44 Orr-Weaver, Terry, 237A, 253A, 278B Mortazavi, Ali, 179A Prabhakaran, Mahalakshmi, 151A* Orzack, Steven, 150B* Morton, Cynthia C., 182B Preston, Elicia, 244B, 251A Otten, Auke, 136B Mott, Richard, 170B Proenca, Rui, 189A Ovcharenko, Ivan, 270B Motwani, Tina, 250B* Provencher, Diane, 67A Öztürk, Sedide B., 259A Moy, Terence, 218B Prusty Rao, Reeta, 160B

Muddukrishna, Bhavana, 182B Pujol, Claude, 165A Mullen, Gregory P., 27 P Muller, Marc, 136B Padgett, Dana, 262B Murata, Takuya, 92B Padilla, Pamela, 63A* Murphy, Coleen, 245A Pagano, Daniel J., 164B* Murray, John, 244B Page, David, 8 Murray, John I., 251A* Pak, ChangHui, 17 Murray, S., 122B Pal-Bhadra, Manika, 73A Mustata, Gabriela, 163A Palese, Peter, 32* Myachina, Faina, 112B Pan, Qi, 226B Myers, Eugene, 244B Pantoja, Mario, 115A* Paolella, Mary J., 173A*, 174B* Pardo-Manuel de Villena, Fernando, 175A* 41 SPEAKER AND AUTHOR INDEX This index includes names in alphabetical order of all invited authors, and co-authors published in this book. The number following a name refers to the abstract’s program number. An asterisk denotes a presenting author. Platform presentations: 1-54, Poster presentations: 55A-285A.

R Salomon, Robert, 62B, 85A Slater, Guy, 170B Rada, Alvaro, 40 Salviati, Leonardo, 83A Slubowski, Christian J., 267A* Rahman, Mohammad M., 189A*, 257A* Samara, Chrysanthi, 258B Smeets, Hubert, 136B Rahme, Laurence, 64B Samson, M., 140B Smith, Cynthia L., 101A Rainey, Meredith, 117A Sanchez, Angela R., 157A* Smith, Sarah K., 229A, 268B* Rand, James B., 27* Sanchez, Cisco, 145A Snider, Paige, 114B Rao, Anjana, 39* Sánchez-Blanco, Adolfo, 244B Soll, David R., 33, 165A Rao, Madhusudhana, 73A Sarkar, Sibaji, 61A Song, Yang, 155A Raz, Tal, 272B Sartain, Caroline V., 279A Sopko, Richelle L., 269A* Read, Timothy D., 247A Sasaki, N., 126B Soumana, Djade, 18 Rechberger, Gerald, 102B Sasner, M., 122B South, Adam, 66B Reddy, Gunda, 153A Sathish, Venkatesan, 148B Srikantha, Thyagarajan, 33, 165A Reddy, Kirthi C., 164B Schedl, Tim, 41, 192B Srinivasan, Chandra, 91A Reinholdt, Laura, 170B Scheifele, Lisa Z., 261A* Staehling-Hampton, Karen, 172B Reymond, Alexandre, 276B Schieltz, J., 30, 100B Stafford, P., 58B Ribeiro, Diogo, 55A Schier, Alex, 96B Stalker, Jim, 170B Ribeiro, Isaura, 55A Schmidt, Esther, 231A Standaert, D. G., 30 Ricard, Guénola, 276B Schwarz, Erich M., 179A Stapleton, Mark, 171A Richard, Guy-Franck, 177A Scott, Michelle, 144B Staveley, Brian E., 109A, 127A, 133A Richard, Vincent, 131A, 132B Ségalat, Laurent, 90B Stein, Lincoln, 231A Richards, Stephen, 4 Seier, Tracey A., 262B* Stein, Sokrates, 70B Richardson, Claire E., 120B*, 164B Sen, Anindya, 234B Sternberg, Paul W., 154B, 179A* Richardson, Helena, 135A Sen, Anindya K., 47* Stettler, Karin, 65A Ristaldi, Maria S., 107A Sen, Debjeet, 273A Stevens, Paul, 143A Ritter, Deborah I., 167A Sendoel, Ataman, 125A* Stewart, Murray, 17 Robert, Jason S., 121A* Seo, Joonbae, 266B Still, Maria, 95A Roberts, Logan, 156B Seyfried, Thomas, 188B Stine, Zachary E., 270B* Rockwood, S., 122B* Shah, Nirao M., 9* Stirling, Peter, 16 Rodriguez, Varenka, 190B Shah, Saumini, 171A Stoepel, Jan, 16 Rohde, Christopher, 258B* Shahi, Varun, 156B Stone, Eric, 285A Roig, Ignasi, 146B Shamovsky, Veronica, 231A Streelman, J. Todd, 181A Rolland, Thomas, 177A* Shampain, Kim, 203A Strehle, Amy P., 93A Rong, Yikang, 211A Sharma, Upasna, 263A* Stuchlik, Olga, 257A Roper, Randall J., 75A, 123A* Shastry, Barkur S., 126B* Stultz, Brian, 255A Roth, Frederick P., 259A* Shaw, Wendy, 245A Stultz, Laura K., 93A Rowell, Jennie L., 71A Shenwu, Ming, 147A Suk, Kyoungho, 259A Rozenberg, Izabela, 70B Sheppard, Samantha A., 264B* Sundararajan, Rangapriya, 87A Rual, Jean-François, 171A Shi, Herong, 273A Suter, Beat, 65A* Ruan, Q., 30 Shi, Yi, 70B Sutera, Vincent A., 262B Rudd, M. Katherine, 247A Shimada, Atsuko, 178B Suzuki, Osamu, 128B* Rudolph, Timothy, 252B Shimada, Toru, 148B Suzuki, Yo, 259A Ruedi, Elizabeth, 138B Shimmi, Osamu, 241A Swanson, Selene, 271A Ruohola-Baker, Hannele, 115A Shin, Hyoung Doo, 161A Swigut, Tomek, 40 Rushforth, Alice, Education and Outreach Shinya, Minori, 178B* Swoboda, Peter, 180B* Workshop Shishimorova, Maria, 266B Swofford, Ross, 169A Russell, Pamela, 53*, 169A Shivers, Robert P., 164B Swofford, Ross W., 181A* Russo, Erilynn, 124B* Shukla, Jayendra Nath, 148B S. Yadav, Jhillu, 73A Ruvkun, Gary, Keynote Address, 218B, 226B Shvartsman, Stanislav, 274B Symonds, Jimmy A., 129A* Singh, Carol M., 129A Singh, Natalia, 265A* S T Singh, Natalia N., 266B Tabaka, Meg, 85A Sabin, Leah, 284B Singh, Ravindra, 265A Tabor, Crystal L., 138B Sabry, Mohamed A., 260B* Singh, Ravindra N., 266B* Taher, Leila, 270B Sahara, Ken, 148B Sipahimalani, Payal, 16 Taheri-Talesh, Naimeh, 118B Sahni, Nidhi, 33, 165A* Siracusa, Linda D., 113A Takeda, Hiroyuki, 178B Saiki, Ryoichi, 91A Sklar, Pamela, 29* Takeo, Satomi, 172B, 271A* Sakai, Noriyoshi, 178B Skrzypek, Marek, 227A Talkowski, Michael, 182B* Saless, Neema, 74B Slade, Jennifer D., 127A* 42 SPEAKER AND AUTHOR INDEX This index includes names in alphabetical order of all invited authors, and co-authors published in this book. The number following a name refers to the abstract’s program number. An asterisk denotes a presenting author. Platform presentations: 1-54, Poster presentations: 55A-285A.

Tamura, Toshiki, 148B Victoria, Guillermo, 206B Wong, Kim, 170B Tan, Ruoying, 57A VijayRaghavan, K., 171A Wong, Koon Ho, 259A Tanner, Felix C., 70B Vijg, Jan, 62B Wu, Chun-Fang, 158B Tannoury, Hiba, 190B* Vilain, Eric, 11*, 145A Wu, Guanming, 231A Taylor, Ashley, 275A Vilhjálmsson, Bjarni, 176B Wu, J.-C., 140B* Taylor, Jon, 168B Vilhjálmsson, Bjarni J., 183A* Wu, T., 140B Tehlivets, Oksana, 102B Villalta, Christians, 284B Wysocka, Joanna, 40* Teixeira-Castro, Andreia, 130B* Villaluz, Alfred T., 129A ten Hallers, Boudewijn FH, 247A Villén, Judit, 233A X Terrell, Ashley N., 156B Volk, Talila, 94B Xiang, Youbin, 229A, 268B Thomas, Adam M., 66B* von Lukowicz, Tobias, 70B Xie, Y., 58B Thomas, James, 42 Vought, Valarie, 41 Xu, Jun, 152B* Thomas, James W., 247A Thompson, John F., 272B* W Y Threadgill, David, 175A Wagner, Jamie, 275A* Yalcin, Binnaz, 170B Tian, Chenxi, 273A* Wählby, Carolina, 218B Yan, Yu-Ting, 105A Tilapia Sequencing Consortium, 181A Wakamatsu, Ai, 236B Yang-Zhou, Donghui, 269A, 280B* Tipping, Marla, 274B* Walsh, Tom, 119A Yanik, Mehmet Fatih, 258B Tishkoff, Sarah, 210B Walters, Rhonda, 116B Yao, Chin-Chin, 278B Titorenko, Vladimir, 131A*, 132B* Walton, Kendra, 172B Ye, Li, 103A Tkachev, Dmitry, 212B Walz, Katherina, 276B* Yi, Song, 33*, 165A Tobin, Sara L., 201A* Walzer, Katelyn, 184B* Yim, Jeongbin, 239A Todd, Amy M., 133A* Wan, Kenneth, 171A Yokokura, Takakazu, 47 Tomczuk, Monika, 101A Wang, Chris, 192B* Yoon, Oh Kyu, 281A* Tonin, Patricia N., 67A* Wang, Haoyi, 277A* Young, Juan I., 276B Trevisson, Eva, 83A Wang, Lingxin, 158B Young, Larry J., 247A Tridandanpani, Sushella, 210B Wang, Molin, 155A Young, Richard A., 51* Tsai, Li-Huei, 28* Wang, Ping, 209A Youngman, Matthew J., 35* Tucci, Michelle L., 134B* Wang, Zhe, 158B Yu, Amy Marie, 282B* Türkel, Nezaket, 135A* Warman, Matthew, 46 Yu, Charles, 171A Washburn, Michael, 271A Yu, Lianbo, 210B U Waterston, Robert, 251A Yu, Lin, 139A Uchio-Yamada, Kozue, 128B Weber, Allison L., 138B*, 209A Yuen, Karen, 16 Ulmschneider, Bryne, 275A Weiler, D., 201A Weinlander, Ken, 196B Ulmschneider, Kiri, 275A Z U. Muckenthaler, Martina, 77A Weinshenker, David, 42 Zarnescu, Daniela C., 193A* Unsicker, Klaus, 77A Wells, Adrienne, 147A Zeng, Changqing, 68B* Urwyler, Olivier, 65A Wells, Lance, 257A Zeranski, Allison M., 173A Wewers, Mark, 210B Zhai, Bo, 171A Wharton, Kristi, 104B V Zhang, Chi, 226B W. Hentze, Matthias, 77A Vafeados, Dionne, 251A Zhang, Haili, 283A* Whitaker-Menezes, Diana, 116B Vaidya, Namita, 171A Zhang, Hongjie, 191A* Whitfield, Zachary J., 278B* Vaidya, Pujita, 171A Zhang, Lianhai, 68B Whitney, Janelle K., 164B Valdar, William, 175A Zhang, M., 100B Wilbe, Maria, 108B Vale, Nilsa, 267A Zhang, Sheng, 141A* Willems, Glenda, 183A van den Bosch, Bianca, 136B* Zhang, Tianxiang, 158B* Williams, Kaitlyn, 223A Vanderby, Ray, 74B Zhang, Yuezheng, 68B Wilson-Berry, Laura, 192B Vanderploeg, Jessica L., 137A* Zheng, Xiao-Feng, 211A Winandy, Marie, 136B van der Spek, Hans, 80B Zhou, Hong-Ming, 114B Winston, Fred, 233A, 238B van Pel, Derek, 16 Zhou, Pei, 213A Witkin, Keren L., 23 Van Vactor, David, 47 Zhou, Rui, 141A, 284B* Witsell, Alice, 62B Vargas, Roberto, 206B Zhou, Shanshan, 285A* Wold, Barbara, 49* Vazquez Paz, Luz de Lourdes, 137A Zhu, Dianhui, 4 Wolf, Matthew, 85A, 139A* Venkatramen, Sreevardhini, 162B Zwahlen, Meghan M., 173A Wolfner, Mariana F., 279A* Vera, Iset, 116B Wolinski, Heimo, 102B Veraksa, Alexey, 185A, 186B, 274B Wong, Christina, 267A Vicenty, Heather M., 174B 43 ANNUAL REVIEWS The Essential Resource for Genetics Research

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