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F-18 FDG PET/CT Imaging of Eccrine Sweat Gland Carcinoma of The F-18 FDG PET/CT Imaging of Eccrine Sweat Gland Carcinoma of the Scrotum with Extensive Regional and Distant Metastases Jin-Suk Kim Department of Nuclear Medicine, Konyang University Hospital, Daejeon, Republic of Korea A R T I C L E I N F O A B S T R A C T Article type: Eccrine carcinoma is an extremely rare malignant skin cancer arising from Case report eccrine sweat glands with a high metastatic potential. It mainly occurs in the elderly, with equal incidence in both sexes. It usually spreads to regional lymph nodes, with liver, lungs, and bones being the most common sites of Article history: distant metastasis. Because of tumor rarity, little is known about the value of Received: 14 Oct 2016 F-18 FDG PET/CT in evaluating this disease. Our case report aims to increase Revised: 4 Nov 2016 current knowledge of F-18 FDG PET/CT in eccrine sweat gland carcinoma as Accepted: 11 Jan 2017 a noninvasive imaging tool for assessing the extension of the disease and detecting distant metastases. Keywords: We reported a 96-year-old man who presented with as lowly progressive, Distant metastasis ill-margined erythematous papules and nodules with a crusted and eroded Eccrine sweat gland carcinoma involving multiple sites of groin, scrotum, penis, left pelvic wall, left hip and F-18 FDG left thigh for >3 years, which became extensive in the past 2 months. The PET/CT was performed F-18 FDG PET/CT to further evaluate the lesions. FDG PET/ Scrotum histologicCT imaging investigation revealed FDG confirmed uptake at the the diagnosis extensive of skin an eccrinelesion, involvement carcinoma. He of lymph nodes, and multiple FDG-avid of liver, skeletal and lung metastases. Please cite this paper as: Kim JS. F-18 FDG PET/CT Imaging of Eccrine Sweat Gland Carcinoma of the Scrotum with Extensive Regional and Distant Metastases. Asia Ocean J Nucl Med Biol. 2017; 5(2): 104-108. doi: 10.22038/aojnmb.2017.19550.1145 Introduction Sweat gland carcinomas are rare malignant tumors, its use in evaluating eccrine carcinoma is infrequently reported in the literature. In this report, I describe the case of an elderly glandtumors carcinomas that were firstinto describedeccrine and in 1865apocrine by man with eccrine carcinoma of the scrotum with tumorsCornil (1, (3, 2). 4), Recent and studiesthese groupshave classified demonstrate sweat extensive regional and distant metastases, for whom F-18 FDG PET/CT was valuable in detecting as regional and distant metastases. Because distant metastasis and assessing the extent of the regionalthe potential lymph for nodelocal tissueinvolvement infiltration, and asdistant well disease. metastasis are indicators of poor prognosis, Case report successful management of the disease. Although A 96-year-old man with a 5-year history identification of these factors is crucial for of end-stage renal disease and hypertension tomography/computed tomography (F-18 FDG was admitted to Division of Nephrology with a PET/CT)F18-fluorodeoxyglucose imaging is useful positron for nodal emission staging complaint of left leg edema. Lower extremity and distant metastasis detection in malignant * Corresponding author: Jin-Suk Kim, Department of Nuclear Medicine,ultrasonography Konyang University showed Hospital, no definitive 685 Gasuwon-dong, evidence Seo-gu, Daejeon 302-718, Korea. Tel: 82426009474; Fax: 82426009499; Email: [email protected] © 2017 mums.ac.ir All rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecom- mons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. F-18 FDG PET/CT Imaging of Eccrine Sweat Gland Carcinoma AOJNMB Kim JS Figure 1. Histologic findings of the genital tumor. The tumor consists of solid nests and tubules extending from dermis (A and B, ×200). Immunohistochemistry reveals positive reactions for epithelial membrane antigen (C, ×200) and carcinoembryonic antigen (D, ×200) of deep vein thrombosis. Physical examination diffusely positive for epithelial membrane revealed extensive ill-margined erythematous antigen (EMA) and carcinoembryonic antigen papules and nodules with crusted and eroded (CEA; figures 1C and 1D). The tumor cells were surfaces involving multiple sites on the groin, negative for HMB-45 and S-100 protein. The scrotum, penis, left pelvic wall, left hip, and patient was diagnosed with eccrine carcinoma. left thigh. Large inguinal lymph nodes were The patient was referred for F-18 FDG PET/ palpated. CT imaging to assess the extent of the disease. Additionally, the patient had a 3-year history The procedure was performed 60 min after of erythematous skin rash of the scrotum, intravenous injection of 7.4 MBq/kg of F-18 which had progressed during the two months FDG and 8 hours of fasting, using a Gemini TF prior to admission. The patient was referred PET/CT scanner (Philips Medical Systems, to Division of Dermatology to undergo a Cleveland, OH, USA). The maximal intensity biopsy of the genital area. Punch biopsy of the projection image (Figure 2A) demonstrated genital skin lesion showed a tumor located in extensive abnormal FDG-avid lesions in the the dermis, which was composed of malignant body. Transaxial CT (Figure 2B) and PET/CT cuboidal cells arranged in solid lobules and fusion images (Figure 2C) revealed enhanced tubules (Figure 1A). Small cystic lumina were nodular thickening and FDG uptake in all the noted within the infiltrative nests (Figure clinically observed skin lesions (arrows). The 1B). The cells had hyperchromatic nuclei with maximum standardized uptake value (SUVmax) of small nucleoli and moderate pleomorphism. these lesions ranged from 3.1 to 13.9. Multiple Immunohistochemically, the tumor cells were FDG-avid metastatic lymph nodes were also Asia Ocean J Nucl Med Biol. 2017; 5(2): 104-108. 105 Kim JS AOJNMB F-18 FDG PET/CT Imaging of Eccrine Sweat Gland Carcinoma Figure 2. A 96-year-old man underwent F-18 FDG PET/CT to determine the initial clinical stage of his eccrine carcinoma. A maximal intensity projection image showed intense FDG uptake in multiple sites including the skin (arrowheads), nodes, liver, and lung. Axial s revealed varying degrees of FDG uptake over the groin, scrotum, penis, left pelvic wall, left hip, and left thigh (SUVmax 3.1-13.9), corresponding to enhancing skin thickening and nodules visualized on CT. D-F multiple FDG- avidenhanced distant CT metastatic (B) and fusion lesions PET/CT were (C)also finding evident in the liver, lung, and bone. observed in the mediastinum, retroperitoneal destructive local tissue infiltration and both space, pelvis, and inguinal region (Figure 2D). regional and distant metastases. The diagnosis Extensive FDG-avid liver (Figure 2D), lung and management of these neoplasms are both (Figure 2E), and bone (Figure 2F) metastatic complex and cumbersome mainly due to lack lesions were also evident. of reports in the literature (5-8). Sweat gland Eccrine carcinoma is traditionally managed carcinomas occur primarily in adult patients, with surgery, especially in the early stages. In with a peak incidence in the fifth and sixth the current case, wide surgical excision was decades of life (6, 9, 10). The majority of cases ruled out because F-18 FDG PET/CT imaging occur in genital skin and the perineum (34.5%), successfully revealed an advanced disease followed by the trunk (26.4%), head and neck stage. Chemotherapy and radiation therapy (18.3%), and lower extremities (13.9%) (6, 8, were considered. After receiving one week 9, 11). of palliative radiation therapy, the patient Eccrine carcinoma is a subtype of sweat suffered from anemia, hypoproteinemia, and gland carcinoma. Eccrine carcinomas possess no liver failure, which was possibly caused by the distinctive clinical features, making diagnosis systemic metastases. Eventually, he expired by gross appearance virtually impossible. They from complications of radiation therapy. usually manifest as non-tender, subcutaneous nodules, primarily in the elderly. Individual Discussion malignant cells are rich in glycogen and stain Sweat gland carcinomas represent a with PAS and are diastase sensitive with rare group of tumors with the potential for prevalent nuclear changes and propensity for 106 Asia Ocean J Nucl Med Biol. 2017; 5(2): 104-108. F-18 FDG PET/CT Imaging of Eccrine Sweat Gland Carcinoma AOJNMB Kim JS lymphatic invasion (10, 11). Sites of sweat skin. Washington, DC: Armed Forces Institute of gland carcinoma metastasis include the nodes, Pathology; 1991. lungs, liver, and bone (6, 11, 12). Metastatic 4. Requena L, Kiryu H, Ackerman AB. Neoplasms deposits from undiagnosed visceral and breast with apocrine differentiation. Philadelphia, Pa: adenocarcinoma are virtually indistinguishable Lippincott-Raven; 1998. microscopically from sweat gland carcinoma 5. Doley B, Das AK, Das M. Metastatic sweat gland carcinoma. J Assoc Physicians India. 2001;49:479-80. and must be considered before diagnosis of 6. Mitts DL, Smith MT, Russell L, Bannayan GA, Cruz metastatic sweat gland carcinoma is made. AB Jr. Sweat gland carcinoma: a clinico-pathological The recommended treatment for all subtypes reappraisal. J Surg Oncol. 1976;8(1):23-9. of sweat gland carcinoma is wide surgical 7. Yildirim S, Aköz T, Akan M, Ege GA. De novo excision and regional lymph node dissection in malignant eccrine spiradenoma with an the presence of clinically positive nodes. Some interesting and unusual location. Dermatol Surg. authors advocate prophylactic regional lymph 2001;27(4):417-20. node dissection, especially in patients with 8. Urso C, Bondi R, Paglierani M, Salvadori A, recurrent lesions after wide excision or highly Anichini C, Giannini A. Carcinomas of sweat undifferentiated tumors. Sweat gland carcinomas glands: report of 60 cases. Arch Pathol Lab Med. are radio-resistant, and chemotherapy is 2001;125(4):498-505. 9. Panoussopoulos D, Darom A, Lazaris AC, Misthos infrequently employed (13).
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