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FOR IN VITRO RESEARCH USE ONLY Europe: [email protected] NOT FOR USE IN HUMANS OR ANIMALS China: [email protected] Aconitase 2 Polyclonal An body Catalog number: 11134-1-AP Background Size: 24 μg/150 μl ACO2(aconitate hydratase, mitochondrial) is also named as citrate hydro-lyase and Source: Rabbit belongs to the aconitase/IPM isomerase family. It plays a key func on in cellular Isotype: IgG energy produc on, and loss of its ac vity has a major impact on cellular and Synonyms: organismal survival. Western blot shows two bands of 83 kDa and 40 kDa. The 40 ACO2; ACO2, Aconitase, kDa fragment decreases with age and oxida ve stress, whereas other fragmenta on aconitase 2, aconitase 2, products with molecular weights between 40 and 83 kDa increased with age and mitochondrial, ACONM, Citrate MnSOD(mitochondrial manganese superoxide dismutase) hydro lyase deficiency(PMID:12459471). Defects in ACO2 are the cause of infan le cerebellar- re nal degenera on (ICRD).
Applications Tested applica ons: ELISA, WB, IHC Cited applica ons: WB Species specificity: Human,Mouse,Rat; other species not tested. Cited species: Human Immunohistochemical of paraffin- Caculated Aconitase 2 MW: 85kd embedded human lung cancer using 11134-1-AP(ACO2 an body) at Observed Aconitase 2 MW: 85kd dilu on of 1:50 (under 10x lens) Posi ve WB detected in Human skeletal muscle ssue, HeLa cells, human heart ssue, human liver ssue, mouse heart ssue Posi ve IHC detected in Human lung cancer ssue, human prostate cancer ssue Recommended dilu on: WB: 1:500-1:5000 IHC: 1:20-1:200 Applica on key: WB = Western blo ng, IHC = Immunohistochemistry, IF = Immunofluorescence, IP = Immunoprecipita on human skeletal muscle ssue were Immunogen information subjected to SDS PAGE followed by western blot with 11134-1-AP(ACO2 Immunogen: Ag1590 an body) at dilu on of 1:400 GenBank accession number: BC014092 Gene ID (NCBI): 50 Full name: Aconitase 2, mitochondrial
Product information Purifica on method: An gen affinity purifica on Storage: PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.