North East

Excelling in health and life sciences

PHARMACEUTICAL MANUFACTURING • CLINICAL RESEARCH AND TRANSLATION RESPONDING TO AN AGEING POPULATION

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Alnwick Ashington Morpeth Bellingham A696 To Scotland A697 Port of Blyth A68 A189 Northumberland Coquet Newcastle Cramlington National Park Rothbury A1 Island Airport Whitley Bay A68 North Shields Port of Tyne South Shields A69 A69 To Carlisle, Hexham Manchester Haltwhistle Blaydon A1 SUNDERLAND GATESHEAD Port of Sunderland A692 A68 Washington Ashington Consett A693 Chester-le- Morpeth Street A690 Seaham Harbour Bellingham A1 (M) A691 A696 Port of Blyth A68 A19 A189 DURHAM Newcastle Cramlington Airport A68 Wingate Whitley Bay Spennymoor Bishop North Shields Auckland Sedgefield Port of Tyne NEWCASTLE To Hartlepool South Shields Newton and Middlesbrough UPON TYNE Aycliffe A69 A69 To Carlisle, Hexham Manchester Haltwhistle Blaydon A688 A1 SUNDERLAND GATESHEAD Port of SunderlandBarnard To York, Castle Leeds, A692 A68 London, Washington Midlands ConsettNorthA693 East Local Enterprise area The North East has a diverse Chester-le- Street A690 Seaham Harbour A1 (M) and vibrant clustering of life A691 sciences, manufacturing and To Edinburgh, Glasgow, Aberdeen

A19 Port of Berwick health services. I believe that DURHAM Berwick-upon-Tweed the work that is being done in Principal rail links A68 Wingate the North East can support more Spennymoor Holy Island Contents A1 Bishop Tyne & Wear Metro growth in the region and make a Auckland Sedgefield Farne Islands strong contribution to a wider To Hartlepool NewtonLEP boundary and Middlesbrough Aycliffe Wooler UK initiative to promote research collaboration, Motorway A688 partnership and investment Key routes globally as part of the Barnard To York, Castle Leeds, Alnwick Introduction 02 Government’s Life Sciences London, MidlandsEnterprise Zones To Scotland A697 Industrial Strategy. Northumberland Coquet National Park Rothbury A1 Island Ports A68 What the data tells us about the sector 04 Airports

Ashington Morpeth World class science and research across four universities 06 Bellingham A696 Port of Blyth A68 A189 Newcastle Cramlington Principal rail links Airport Whitley Bay North Shields The North East health and life sciences ecosystem 06 Port of Tyne NEWCASTLE UPON TYNE South Shields A69 Tyne & Wear Metro A69 To Carlisle, Hexham Manchester Haltwhistle Blaydon • An outstanding and innovation-driven healthcare system A1 SUNDERLAND GATESHEAD Port of Sunderland A692 A68 with a strong and high-performing clinical trials community 10 LEP boundary Washington Consett A693 Chester-le- Street A690 Seaham Harbour A1 (M) • Globally focused pharmaceutical manufacturing 12 Motorway A691 A19 DURHAM • A vibrant and effective innovation environmen 14

A68 Wingate Key routes Spennymoor Bishop • Research and innovation site 17 Auckland Sedgefield To Hartlepool Newton and Middlesbrough Enterprise Zones Aycliffe

A688 John Bell GBE, FRS, FMedSci Barnard To York, A broad and high-quality education offer 18 Ports Castle Leeds, London, Midlands Regius Professor of Medicine, Airports University of Oxford. Chairman, A mature and accessible business support ecosystem 20 Office for the Strategic Coordination of Health Research. Sponsor of the Life Sciences Industrial Strategy, a Government White Paper. Principal rail links Tyne & Wear Metro Page | 01 LEP boundary Motorway Key routes Enterprise Zones Ports Airports : A unique environment for health and life sciences and medicines manufacturing. We have excellence in quality of care, health innovation, working with companies and ageing. Through the health and life sciences working group, we bring together the North Global health services and markets A thriving life science community with: • A diverse range of business East’s health, life sciences are being shaped by rapid models, international links and a research and manufacturing development of health care • World leading health research strong export performance as community. We are technologies, resulting in a shift and outstanding NHS healthcare they respond proactively to a committed to ensuring that towards more personalised organisations, with a record of challenging global outlook our unique assets continue to treatments and the need to respond health innovation and working flourish and deliver real to the health and social care with companies • Direct links to the UK Catapult economic and social impact. Network, indirectly through the A key part of this mission is to implications of an ageing population. • A vibrant SME base in medical The North East of England has a Centre for Process Innovation project our strengths to the technologies including precision which operates a number of noted rest of the UK and beyond, unique combination of assets, medicine and medical technologies, capabilities and networks that can innovation facilities in the region. and to identify opportunities and testing and clinical trials for collaboration and support the delivery of the UK’s An internationally recognised response to this challenge. • Centres of excellence in precision investment which can enable specialism in ageing and the strengthening of our medicine, digital health, advanced age-related diseases: Our key assets and areas therapies and biopharma contribution to global health of opportunity manufacturing. • Newcastle is a globally recognised and national prosperity. Our regions life scientists and hub for the development of medical An established pharmaceuticals science and social research in researchers, innovative businesses, manufacturing sector: medicines manufacturers and response to the challenges and health care professionals, are • An established, globally opportunities of ageing populations contributing to the improvement competitive sector including 15 • The Newcastle campus for ageing of global health, creating jobs and pharmaceutical manufacturers and vitality is Europe’s largest generating wealth for the region with deep sector knowledge and multidisciplinary site focused on and the UK. We have: a global outlook ageing and the National Innovation Centre for Ageing will drive innovation delivery in this area. Working together through the health Our assets are located within a well- and life sciences working group. networked environment which includes key sites and facilities dedicated to the Partners in the region are working closely development of health and life sciences Michael Whitaker together, supported by the North East sectors. We have a number of business Local Enterprise Partnership, to identify clusters and networks and a strong Member of North East LEP education offer in both health and innovation board and chair of the North East LEP life sciences and deliver opportunities to support associated sciences. working group growth and employment in the region. Page | 03 The North East of England’s What the data tells us about the sector What does the health and life science sector look like? immense capability in life sciences is reflected in the growth of this sector and its psychology, psychiatry and The map below shows the clustering of North East health and life sciences businesses by employment numbers. substantial offer for business. Pharmaceuticals manufacturing neuroscience and 19% in clinical

• The manufacture of pharmaceutical medicine2. 47% of the research in The region is a world leader in products contributed £590 million to biological sciences undertaken by clinical research which can North East Gross Value Added in is rated as 4* boast national leadership in 2016, with a location quotient of 1.6. ageing and smart data. Its rich Pharmaceuticals is one of the highest • The Witty Review3 rated North asset base includes expertise Life Science & Healthcare: productivity sectors globally. The East universities in the top 20 Manufacture of Basic Pharmaceutical Products in precision medicine, rare 1 for research publications for 11 and Pharmaceutical Preparations North East business base includes : Manufacture of Medical and Dental Instruments and Supplies disease and cancer as well as subjects including life sciences Scientific Research and Development pathology and diagnostics. It is and regenerative medicine home to outstanding research centres including the National 71 companies in • Between 2007 and 2017, North East Institute of Health Research biopharma, employing 4, 001 organisations secured funding of Total Employment by Postcode: people and a turnover of £594 m £94 million from the Biotechnology Alnwick (NIHR) Innovation Observatory, >500 the National Innovation Centre and Biological Sciences Research 250-500 Council and £118 million from the 100-249 for Ageing, the National 50-99 Medical Research Council 25-49 Innovation Centre for Data, <25 Newcastle and Durham 91 companies in • North East Health Trusts are UK universities and nationally Ashington, Bedlington, Blyth, Cramlington & Morpeth medtech, employing 2,570 leading for their involvement in leading NHS teaching trusts. people and a turnover of £505 m clinical research, with Newcastle Hospitals NHS Trust being ranked Newcastle - Gateshead first for the last six years. North & South Shields

• In the wider life sciences community, Ageing Sunderland 50 life sciences companies were Chester-le-Street, Houghton-le-Srping & Washington formed in the North East region Durham City between 2007 and 2016 employing The Newcastle University Institute Peterlee 279 employees and generating Consett & Stanley for Ageing comprises a network Spennymoor a turnover of £21.7 million. of over 500 researchers Corbridge & Hexham Research excellence

Barnard Castle Dr Hakim Yadi • The 2014 Research Excellence with a wider network of academic and 0 10 20 30km Based upon Ordance Survey mapping with the permission Framework rated 29% of North external collaborators contributing to of Her Majesty’s Stationery Office. © Crown Copyright OBE CEO of the Northern reserved. Licence number AL50684A Health Science Alliance East research in biological sciences the regions outstanding reputation for as 4*, as was 22% of research in research into ageing.

1 Office for Life Sciences 2 Defined as world-leading in terms of originality, significance and rigour 3 Encouraging a British Invention Revolution, 2013 Page | 05 The North East World class science and research health and life across four universities sciences ecosystem Research Collaboration funded by NHS collaboration Sunderland University the NIHR with leadership of work Newcastle University and Biomedical Research Unit in focused on diseases of the liver. A feature of the work of the In September 2019, university is its extensive Sunderland University will The North East science, Lewy Body Dementia, both It hosts: Ageing and health collaborations with the Newcastle partnership working with the NHS, open its new School of research and innovation With over 600 academic staff • The Wellcome Trust Centre for in particular with Newcastle-Upon- Medicine, one of only five eco-system upon Tyne Hospitals NHS involved in different aspects of Foundation Trust. Mitochondrial Disease Tyne Hospitals NHS Foundation new medical schools, The North East hosts an internationally ageing research, Newcastle is an Trust (NUTH). Newcastle’s joint established to address the They are supported by strong • The Medical Research Council recognised innovation eco-system and acknowledged leader in the NHS/university translational regional imbalance of collaboration with Newcastle based Single-Cell Functional Genomics Unit. translation environment including: scientific response to global infrastructure includes: medical education places demographic change. Key areas research institutes; Rare diseases and cancer across England and to widen • World class science and research of research and learning include; • Clinical research: the NIHR Clinical access to ensure the • Northern Institute for across four universities Newcastle University’s Institute of Research Facility is a partnership profession reflects the • The process of ageing Cancer Research Genetics, based at the International between NUTH, the leading UK communities it serves. With a • An outstanding and innovation- Trust for recruitment to clinical • Institute of Cellular Medicine Centre for Life, is acknowledged for track-record of excellence in driven healthcare system with • Ageing well its world leading research into rare trials, and Newcastle University. medical education spanning a strong and high-performing • Societal responses to the global • Institute of Genetic Medicine diseases. This is an area of research www.ac.uk/crf almost 100 years, the clinical trials community phenomenon of ageing in areas with increasing worldwide • Diagnostics North East (DNE): University is now well-placed including finance, culture and • Institute of Neuroscience. • Being globally focused with recognition of the need for a Newcastle is the only UK centre to address the chronic social relations. strong trade flows, particularly • The National Innovation Centre for specialised focus. The Newcastle with a joint Medical Research shortage of doctors in the facility combines research with North East. Focusing on GP in pharmaceutical manufacturing Within the university, the Institute Ageing (NICA) works with business Centre/Engineering and Physical practical diagnosis, treatment and and Psychiatric training, the of Ageing acts as a hub, drawing and partners to develop solutions Sciences Research Council • A vibrant and effective care. The Northern Institute for new programme will together staff from across the to a range of age related supported Molecular Pathology innovation environment Cancer Research (NICR), is a complement existing medical university to focus on a wide- challenges and opportunities. NICA Node. DNE also hosts Newcastle’s is co-located with the National multidisciplinary research institute provision in the region and • Research and innovation sites ranging inter-disciplinary In Vitro Diagnostic Co-operative Innovation Centre for Data offering which acts as a national centre of add to the diversity of hosting a range of innovation programme focused on research and the National Institute of a platform for collaborative excellence for clinical trials and medical schools in the UK. hubs and facilities including and innovation, engagement and Health Research funded innovation in digital solutions. development of bio-markers for national centres of excellence knowledge transfer, and learning Innovation Observatory. cancer drug discovery focused on and teaching. A number of centres www.diagnosticsnortheast.org Precision medicine both adult and childhood cancer. As • A broad and high-quality are developing within the institute Newcastle has a well developed part of the NIHR network of • Genomics: the North East also education offer with more than focused on specific issues and programme focused on precision experimental cancer medicine hosts a Medical Research Council 40,000 higher education opportunities including: students studying STEM subjects medicines. It leads two stratified centres it helps to ensure that the Single Cell Functional Genomics • The National Institute of Health medicine consortia funded by the UK remains at the forefront of Unit, a Genomics Medicine Centre, • With dedicated scaleup support Research (NIHR) funded Medical Research Council and is a key international development of and an External Assessment for those that have the potential Biomedical Research Centre in partner in three others. It co-chairs cancer therapies. Centre for the National Institute for to grow rapidly. ageing and long term conditions the Rare Diseases Translational Health and Care Excellence.

Page | 07 Durham University Northumbria University In the spotlight Durham’s interdisciplinary approach to health Research within two multi disciplinary teams at and life sciences builds on their research Northumbria University directly address the health Kromek excellence and innovative collaboration in a and well being needs of individuals and communities Kromek is a Durham University spin out number of areas including; and the challenges faced by life science industries. that uses cadmium zinc telluride Key expertise includes: • Biophysical sciences including major industrial technology (a semiconductor compound collaborations in biophotonics and biosensors Health and Integrated Social Care made up of three elements – cadmium, zinc and tellurium), to design, develop and • Medical humanities, involving collaborations • Nutrition: delivery of controlled human trials produce x-ray and gamma ray imaging across world leading humanities and social determining the efficacy of functional foods and and radiation detection products for the science departments with clinical science and supplements on cognitive function, exercise medical, security screening and nuclear patient groups in mental health and respiratory performance and the gut microbiome markets.Kromek started with two illness to extend management and care options employees and now employs over 100 • Sport and exercise science: applying knowledge globally, with over 50 being based at their gained from elite athletes to the needs of those • Synthesis of pharmaceutical intermediates; skin head quarters at NETPark, in Durham. biology including wound healing, skin ageing, with chronic conditions to deploy rehabilitation tissue engineering and regenerative medicine services into the community ‘The proximity to the universities and the infrastructure are very important factors • Digital health: expertise in design thinking linked The university has extensive experience in the for our growth in the North East. with expertise in computing, human computer secure handling of large datasets sourced from Ultimately having a presence in Europe is interactions and service implementation. public healthcare data. very valuable to us and we intend to stay Building on common expertise in innovation in Bio-economy at NETPark for many years to come. formulated products, healthcare photonics and We’ll continue to look at acquisitions, but • Biocatalysis: developing enzymes using natural personal care, a strategic partnership with the that’s just part of a plan which will also genomic resources optimised via directed evolution Centre for Process Innovation (CPI) combines include a lot of organic growth.’ techniques. Developing alternatives for chemical Durham’s research excellence in chemistry, processes in the pharmaceutical and food sectors biology, physics and engineering with the accessed via Nzomics, an enzyme design service. translational expertise of the CPI. • Advanced materials: controling of interactions between liquids and surfaces. Particularly, the shaping of liquids by nano-structured surfaces, the creation of particle encapsulated droplets and nematic liquid crystals.

• Microbiome: microbial ecosystems from industrial bioprocesses to the human gut, accessed via Nuomics a microbial DNA sequencing service for the agriculture, food and pharma sectors. Dr Arnab Basu, CEO, Kromek

Page | 09 An outstanding and innovation driven healthcare system with a strong and high-performing clinical trials community.

In the spotlight North East Health and Care services Across the North East LEP area, health and social Newcastle upon Tyne Hospitals NHS modern medical facilities such as laboratories and care services are commissioned and delivered Foundation Trust radiology services.” through seven Local Authorities, seven Clinical Newcastle upon Tyne Hospitals NHS Foundation The 2016 Care Quality Commission (CQC) Commissioning Groups (CCGs) and nine NHS Trust is a world-class provider of healthcare and one inspection rated Newcastle upon Tyne Hospitals Foundation Trusts (FTs) - six acute trusts, two of the largest NHS organisations in the UK. as ‘outstanding’. mental health trusts and one ambulance service. Offering the second highest number of specialist The Trust is also consistently in the top ranks of Despite longstanding health and care challenges in services than any other group of hospitals in the the NIHR national league tables for numbers of the population in terms of life expectancy and health UK, Newcastle upon Tyne Hospitals manages recruiting studies, numbers of open commercial status, the region has good coverage of high quality over 1.72 million patient ‘contacts’ every year. Its portfolio studies, and percentage of commercial primary care services, with fewer patients per GP flagship services include; the Cardiothoracic Centre studies recruiting patients to time and target. than other areas and high relative patient satisfaction at the Freeman Hospital, the Great North Children’s and practice outcomes standards compared with Hospital, and the major Trauma Centre Newcastle upon Tyne Hospital’s state of the art others areas. Five of the seven CCGs are rated ‘good’ at the . clinical research facilities provide the capability or ‘outstanding’ by NHS England, adult social care is to undertake trials ranging from Phase 1 (first in rated strongly and three of the Trusts are rated as Professor Julia Newton, Deputy Medical Director human) to Phase 4 (post-marketing). Newcastle outstanding by the Care Quality Commission. at Newcastle upon Tyne Hospitals NHS Foundation upon Tyne Hospitals also hosts the NIHR Clinical Trust said; Trust said; “With around 13,500 staff, Research Network for the North East and North These organisations operate outside the North East Newcastle upon Tyne Hospitals is one of the North Cumbria. area in some cases, for example delivering health East’s major employers. Because of our outstanding care services in the Tees Valley and into Cumbria. reputation, we attract and retain some of the On a regional level, the Trust has built strong Many of the trusts have a strong research orientation country’s most highly respected healthcare experts. partnerships with key organisations including the and work closely with universities and other research Northern Health Science Alliance and the Academic and innovation partners in the region, including “Our consultants based here in the North East are at Health Science Network for North East and North through as the Academic Health Science Network the cutting edge - nationally and internationally - for the Cumbria. It is the lead partner of a new Northern North East and North Cumbria (AHSN NENC). latest developments in the fields of ageing, , Alliance Advanced Therapies Treatment Centre, cancer, genetics and transplantation. We’re recognised together with advanced therapies companies, Research oriented trusts work with other partners as a leader in healthcare research and development. universities and the NHS covering the North of across the north of England through the Northern England and Scotland. Health Service Alliance (NHSA) and with clinical and “We’ve also recently completed the largest research partners in Scotland healthcare modernisation programme in the North For more information, visit East, spending £330m to increase the number of www.newcastle-hospitals.org.uk beds and operating theatres, and provide more

Page | 11 Globally focused pharmaceutical manufacturing In the spotlight

Accord Healthcare In January 2018, Accord Pharmaceutical manufacturing lean working practices, upskilling, Key locations Healthcare opened its new reducing or mitigating costs and 22 acre site in Fawdon The North East pharmaceutical ever increasing quality, compliance The North East is an excellent Newcastle, taking over a site sector is strongly connected to and supply agility. Raw materials, location for medicines previously owned by Sanofi. international markets and supply chemicals and reagents are manufacturers who are based An initial staff of 60 will grow chains, importing raw materials sourced from Asian markets such around the region taking to a full complement of 500 and processing equipment, and as China and higher value advantage of established facilities jobs over the coming years exporting the vast majority of processing equipment and and developing sites - you can through investment into a five manufactured products. It includes specialised raw materials from see on the map on page five. year growth strategy focused a number of contract development North America, other parts of There are a number of key sites and on high tech pharmaceutical and contract manufacturers, key the UK and Ireland, and facilities which are being developed manufacturing. supply chain companies and large mainland Europe. multinational drug developers offering opportunities for supported The Fawdon site will be using a range of business models investment or clustering. Accord’s first facility including business services, producing generic technology ranges and scales An average of 86% of North East Enterprise Zone and effervescent medicines, and of production. Accelerated Development Zone North East pharmaceutical become its regional centre production is exported Key brands include GSK, MSD, Sites around the region have been for excellence for Aesica, Sterling, Arcinova and with 64% of finished selected since April 2012 to support effervescent tablets and Piramal Healthcare. products going to the economic growth by providing tax other types of medicine. United States. breaks and a range of interventions to help businesses start up grow It will export to over 35 and expand. Additional sites went countries across Europe North East live in April 2016. Collectively, the and beyond. pharmaceutical North East Enterprise Zone is made manufacturing in the North The sector is growing and up of 21 sites. The Newcastle- East LEP area makes GVA expecting to recruit additional jobs Gateshead Accelerated contribution estimated to be to its current manufacturing and Development Zone makes a over £1.25 billion per annum research workforce in the similar offer in the urban core of coming years. the region focused across five sites including Newcastle Helix. The North East is Many of the businesses operate an Five pharmaceutical recognised as a outsourced logistics model with manufacturing sites in the North logistics providers based in the globally focused East are internationally owned. It is region, through the strong air and a highly efficient sector with region with strong sea links from North East competitiveness achieved through trade flows. transport gateways.

Page | 13 A vibrant and effective innovation environment National innovation agencies UK innovation agencies are actively engaged in the In the spotlight North East, working closely with the North East LEP and regional partners. Innovate UK were founding Centre for Process Innovation The North East is home to a cluster FUSE (The Centre For Translational BioNow members of the North East innovation board, The of businesses, addressing the global Research In Public Health) Knowledge Transfer Network supports Venturefest CPI, part of UK’s High Value challenges of the health and life BioNow supports business growth, North East and the Innovation Supernetwork. Manufacturing Catapult, is a leading sciences sector. These are engaged The centre is a formal collaboration competitiveness and innovation technology and innovation centre. CPI businesses which are supported by between public health researchers within the biomedical and life Catapult centres are a network of world-leading works with academia and industry to a strong community of innovation across the universities in the North sciences sectors across Northern centres designed to transform the UK’s capability for help translate research ideas into and cluster networks, detailed below. East of England and aims to England. It provides membership innovation in specific areas and help drive future commercial products and processes translate public health research into services to add value and cost economic growth. There are currently 10 national across the healthcare sector. public policy and practice. fuse.ac.uk efficiency to scientific, clinical and catapults and six have established centres of different The National Institute for Health business operations within early scales and roles in the North East, collaborating with Focus areas include key parts of the Research North East and North stage and growth-oriented firms. the local innovation community. The two highlighted pharmaceutical and med tech value Cumbria Clinical Research Network First for Pharma bionow.co.uk below are active in the North East Life Sciences sector. chain: From the development of novel This Network is the best performing First for Pharma brings together They are: therapies, diagnostics and medical representatives of some of the devices to the design of drug local Clinical Research Network in The Northern Health Science Alliance the UK and provides access to world’s largest pharmaceutical and • The Centre for Process Innovation (CPI), part of formulations; digitally-enabled medicines clinical trials for NHS patients biologics manufacturing businesses The Alliance brings together the High Value Manufacturing Catapult manufacturing and smart packaging across all disease areas and care alongside smaller organisations in North health sciences cluster from solutions. CPI can accelerate the fields of manufacturing, Liverpool to Newcastle and has • The North East and Tees Valley Digital Catapult commercialisation by applying its delivery settings. It is hosted by The Centre, based at Sunderland Software City. Newcastle upon Tyne Hospitals NHS medical devices, assistive delegated authority across eight NHS innovation processes, expertise in access Foundation Trust, which is the UK’s technology and health informatics. Trusts, including Newcastle upon The North East Health and Life Sciences sector worked to finance and its technical capabilities in leading Trust for research delivery It aims to support the regional Tyne Hospitals NHS Foundation Trust, closely with the Cell & Gene Therapy Catapult to deliver biotechnology, electronics & sensors, of clinical trials and a Pfizer INSPIRE pharmaceutical manufacturing eight universities, including Durham new curative advanced therapies in the NHS. The award photonics, nanotechnologies, global partner. nihr.ac.uk ecosystem. firstforpharma.co.uk and Newcastle, and four Accademic to the Newcastle upon Tyne Hospitals NHS Foundation formulation and materials chemistry. Health Science Networks to enter Trust of a £9m partnership with industry will provide into industry research partnerships, MedConNect North The North East Process clinical infrastructure that will deliver these ground Industry Cluster (NEPIC) across our whole Northern breaking new therapies to patients in the North. MedConNect North supports geography. thenhsa.co.uk access to all aspects of the North NEPIC is an award winning In March 2018, the Government announced an East NHS in the region offering a membership cluster organisation The Innovation Supernetwork investment of £9million into the Northern Alliance bespoke service to SMEs, national working with chemical using industries Advanced Therapies Treatment Centre (NAATTC) is a The Supernetwork supports and international medical in the North East of England. It covers partnership between a dozen therapeutic and supply innovation delivery by bringing technology companies seeking to chain companies and eight healthcare providers in a broad sweep of chemistry focused together a cross sector of networks navigate the medical technology Leeds, Newcastle, Edinburgh and Glasgow that will industries including petrochemicals, and organisations to enable and research and innovation pathway. deliver these therapies to the 15m population that the polymers and materials, fine and facilitate business to business It also supports NHS staff to NHS covers in the North East, Yorkshire and Scotland. speciality chemicals, pharmaceuticals, collaboration and promote links encourage, drive and develop The NAATTC is part of a national programme with two biotechnology and renewables to build between business and research innovation within their organisation other ATTCs to act as pathfinders for adoption of on the region’s powerful industrial bodies, catapults and innovation medconnectnorth.com these therapies to benefit NHS patients across the UK. base. nepic.co.uk hubs. supernetwork.org.uk

Page | 15 Research and innovation sites

In the spotlight Across the region, there are key locations which support the In the spotlight development of health and life Academic Health Science Network sciences and provide competitive Innovation Pathway Newcastle Helix (Science Central) locations for investment. The Academic Health Science Network Newcastle Helix is the UK’s biggest urban development outside These include: North East and North Cumbria is one of of London, bringing together industry leaders, businesses and top 15 organisations in the National AHSN researchers in an innovation community. It combines prestigious • Internationally recognised science commercial and residential space with first class research and Network. AHSNs were established to deliver parks and research campuses a step-change in the way the NHS identifies, education facilities in the heart of Newcastle. It is a centre for hosting innovation hubs, research science, innovation and business growth with a broad range of develops, evaluates, adopts and spreads centres and laboratories. new technologies. The key emphasis is commercial, research and laboratory facilities. It is home to a on partnership working and collaboration • Industrial sites which are National Innovation Centre for Ageing and Data, the Core (where between the NHS, academia, the private designated to support ongoing knowledge-based science and technology SMEs are based) and sector, patients and public, third sector and cluster development Newcastle University’s award-winning Urban Sciences Building. other external partners, to: The aim of the development is to become a major UK hub for • Leading public sector health scientific research, and technology businesses, creating • transform patient safety organisations with a UK leading knowledge-based jobs for future generations. research pedigree. • improve population health outcomes Adoption Culture Clinical Trials The Biosphere Markets Ideas Brokering NETPark – the North East • support economic growth across the The new 90,000 sq. ft purpose-built £25m facility is tailored to Finance Evidence Success Technology Park North East and North Cumbria region. the commercialisation of life science and innovation, research and Intellectual Property Commercialisation Located at Sedgefield in County development. It offers high quality biology and chemistry laboratories, The Innovation Pathway is the vehicle used to Durham, NETPark offers a range Grade A offices and conference space. Within walking distance of support companies through the innovation life of offices and laboratories and Newcastle University, Newcastle Hospitals NHS Foundation Trust and cycle and ensures technologies are clinically hosts a number of innovative National Innovation Centres this unique facility provides a global evaluated with the express intention of Since the inception of the businesses. It is an internationally base for North East spin-out businesses and inward investors. adoption. This is further supported by the NHS AHSN we have supported recognised location for science Trusts in the North East of England who are and technology companies. This recognised as early adopters of technology; more than 300 companies includes the National Innovation the AHSN also has membership at Board and created 60 jobs, as Centres led by CPI, including level from NHS Trusts, Clinical Commissioning well as securing over National Printable Electronics Groups (CCIs) and Universities within the £4,5 million of Centre, National Formulation region. Local company, Kromek (featured on Centre and National Centre for page 8) benefitted from the services offered additional investment. Healthcare Photonics. under the Innovation Pathway. The Biosphere

Page | 17 A broad and high-quality education offer In the spotlight

Working in a world-class centre for research: Anthony Lagnado, Newcastle University PHD student The North East has a broad and Newcastle University has a world Further Education high quality education offer renowned medical school ranking Anthony Lagnado grew up in the South of France including four Universities, nine amongst the top 100 global The North East is currently the only and today he is completing a PhD at Newcastle further education colleges and universities for life sciences and region in England, where all further University’s Institute for Ageing, studying the around 1, 300 primary, secondary medicine in the 2016 Quacquarelli education (FE) colleges are rated either changes that take place within our cells as we age. good or outstanding. Additionally there and other schools. Symonds World University rankings. After studying for his first degree in the South It was ranked ninth for medicine in is a wide range of private provision Ensuring that the education system of France, followed by Master’s degrees in the Complete University Guide 2018. offering additional specialised is effective and drives the skills the courses. The FE sector is vibrant, Montpellier and Grenoble, Anthony worked as regional economy needs is a key The faculty of health and life closely connected with regional a marketing manager within the science sector priority for the Strategic Economic sciences at Northumbria employers and with a range of in Paris before making the move to North East Plan. The North East LEP is working University works closely with technical education and qualifications England in 2013. to facilitate a number of system- employers across an extensive focussing on key employment sectors “I came to the North East of England because of wide skills activities; including a portfolio of subjects including in the North East. The apprenticeship the reputation of Newcastle, notably the University focus on STEM education. biology, biomedical sciences, reforms and proposed technical and its Centre for Ageing,” said Anthony. chemistry, forensic science, food education reforms offer further Higher Education and nutritional sciences and opportunities for employers to “After my Master’s degrees I was looking for a PHD applied health professions. work closely with the FE sector. and for that I applied to many different places. I The North East has more than was most interested in Newcastle because it’s one 82,000 higher education of the best institutes in the world. The main hub for students, with almost half research into the biology of ageing is here and the studying STEM subjects. Subjects equipment we have is some of the best. aligned to health and life sciences account for the largest proportion “We have connections and collaborations with of STEM students. other centres for research in the USA and Europe and Newcastle is one of the biggest centres for this Durham University ranks in the top research in the world. 100 global universities, complemented further by its “In addition, the cost of living is not very expensive chemistry department being here and I have explored the coast, the city and the ranked third in the UK for teaching quayside as well as visiting Scotland – in fact I’m in in the Complete University Guide training for the Edinburgh marathon. 2018, reflecting the departments long term and continued “When you take into consideration the cost of commitment to teaching and living, the research facilities and the area as a student experience. whole, it’s one of the best places to be.”

Page | 19 A mature and accessible business support ecosystem In the spotlight

Glythera

Glythera is a drug development company specialising in the In addition to the work of specialist Scaleup North East The North East Fund development of stable, safer and superior Antibody Drug life sciences network and cluster Conjugates (ADCs) for the treatment of difficult to treat solid organisations, the North East Launched in January 2018, Scaleup tumours. From its bases in Newcastle upon Tyne and Boston, MA, offers a mature business support North East aims to increase the it has four ADCs in pre-clinical development and anticipates these The North East Fund launched eco-system which is accessible to density of North East scaleup entering the clinic by 2021. Glythera is focused on improving the in 2018, a suite of five loan, businesses in all parts of the businesses, by supporting existing lives of patients living with cancer.Glythera’s new state-of-the- equity and mezzanine funds economy, with dedicated scaleup scaleups to continue to grow and art facility will be at Newcastle’s Helix development. It will be specifically created to provide support for those that have the by supporting businesses with home to PhD-trained scientists including chemists and biologists finance for North East SMEs. potential to grow rapidly. scaleup potential to realise scaleup working across candidate discovery, development and the pre- levels of performance. Over a period of five years, clinical assessment of its lead ADC candidates. Glythera works The North East Growth Hub The support is flexible and tailored the £120 fund will invest in closely from its Newcastle Headquarters with its national and to the needs of the business. over 600 businesses, creating international partners within the life sciences sector. The Growth Hub provides targeted Scaleup partners, who have a track jobs, securing further private access to business support and Dr David Simpson, Chief Executive Officer of Glythera said: “The record in scaling businesses, work sector investment, generating finance to people wanting to start, North East region has a particularly strong health and life sciences with businesses to define growth economic growth and creating grow or improve a business. The sector and supports a large number of intermediaries, many with objectives and mentor business future legacy funds. Invest North East England Growth Hub provides access to over well-developed industrial capabilities. We’re able to make, develop leaders to take the right action at 220 sources of business advice and and trial our products all within one small area which makes the Acting as a single point of contact, the right time. The Fund’s stakeholders support from across the region and include the European Regional North East a very economical place to do business. There is a Invest North East England (INEE)is from UK programmes. scaleupnortheast.co.uk Development Fund, the huge amount of expertise and knowledge in the region as well the North East Combined European Investment Bank as a talented pool of graduates and PhD students from the local Authority’s strategic inward northeastgrowthhub.co.uk and the existing regional universities. There’s also a fantastic quality of life on offer, which investment body. legacy funds, managed by makes the North East a great place to live as well as work.” INEE works closely with the North North East Access to Finance. East Local Enterprise Partnership, Locally based Fund Managers local authorities and also has (FCA approved fund access to an extensive partnership management companies) will network of support agencies, manage the five funds, all of sector specialists, universities, which have a different focus colleges, knowledge networks and and remit on behalf of The business organisations throughout North East Fund Limited. the North East of England region.

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Page | 21 Find out more

North East LEP www.northeastlep.co.uk 1 St James Gate, Tel: 0191 561 5420 Newcastle upon Tyne, Email: [email protected] NE1 4AD @northeastlep