Anti-KIT (Mutation L576P) Monoclonal Antibody, Clone XH078 (DMAB-DCC072) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-KIT (mutation L576P) Monoclonal Antibody, clone XH078 (DMAB-DCC072) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Anti-KIT (L576P) Mouse Monoclonal Antibody. The antibody ( Cat # DMAB-DCC072 ) is suitable for ELISA, WB.

Antigen Description Tyrosine-protein kinase Kit, also known as proto-oncogene c-Kit or CD117 or Mast/stem cell growth factor receptor (SCFR), is a receptor tyrosine kinase protein that in humans is encoded by the KIT gene. Activating mutations in this gene are associated with gastrointestinal stromal tumors, testicular seminoma, mast cell disease, melanoma, acute myeloid leukemia, while inactivating mutations are associated with the genetic defect piebaldism.

Specificity Recognizes L576P mutant, but not wild-type KIT of vertebrates.

Immunogen A synthetic peptide from the internal region of KIT which includes the mutation of L576P, human origin.

Source/Host Mouse

Species Reactivity Human

Clone XH078

Purification Purified from ascites

Conjugate Unconjugated

Applications ELISA, WB

Format Liquid

Concentration 1 mg/ml

Size 100 μL

Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol

Preservative None

Storage Store at -20°C. Avoid freeze / thaw cycles

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Gene Name ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK13) [ Homo sapiens ]

Official Symbol KIT

Synonyms KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT; SCFR; C-Kit; CD117;

Entrez Gene ID 3688

Protein Refseq NP_002202.2

UniProt ID P05556

Pathway Acute myeloid leukemia; Adaptive Immune System; Cardiac Progenitor Differentiation; Cytokine- cytokine receptor interaction

Function ATP binding; cytokine binding; metal ion binding; protease binding

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]