Cell Death and Differentiation (2005) 12, 1255–1257 & 2005 Nature Publishing Group All rights reserved 1350-9047/05 $30.00 www.nature.com/cdd Book Review Proteasome inhibitors in cancer therapy: death by indigestion M Rossi1, A Oberst2, A Emre Sayan1 and P Salomoni*,1 1 MRC, Toxicology Unit, Leicester, UK; 2 IDI-IRCCS Biochemistry Lab, c/o University of Rome Tor Vergata, Rome, Italy * Corresponding author. P Salomoni. E-mail:
[email protected] Cell Death and Differentiation (2005) 12, 1255–1257. doi:10.1038/sj.cdd.4401701 Proteasome Inhibitors in Cancer Therapy. Cancer Drug Discovery and Development. By J Adams. Humana Press, Totowa, New Jersey: 2004. pp 312. ISBN: 1-58829-250-9 As Eugene Garfield said, while it is easy to recognize a good same issue containing manuscripts from scientists that have paper, it could be more difficult to recognize a bad paper. In originated in this field.7–10 fact, the results could be weak, but the conclusion could still For those of us engaged in basic research in the field be right, even though not fully supported by the data shown. of cancer and apoptosis, the hope that our work might, in Preliminary reports could also fall in this category. After some small way and at some future juncture, contribute to all, it was not a Cell but a BBRC paper – only a little BBRC of the clinical treatment of human cancers is a major motivator. three impact factor – describing a novel experimental model Proteasome Inhibitors in Cancer Therapy, edited by Julian in which to study ATP-dependent proteolysis.1 In a lysate Adams, which is part of the ‘Cancer Drug Discovery and from rabbit reticulocytes, where the proteolytic activity was not Development’ series from Humana Press, tells the happy tale due to lysosomes (pH optimum of 7.8), they separated two of one drug’s journey from concept, through development, fractions in a DEAE cellulose column, each one individually to FDA approval, and application.