2020 STATE OF THE HEART TRANSFORMING CARDIOVASCULAR CARE ACROSS KENTUCKY 2 | UK Gill Heart & Vascular Institute | 3

TABLE OF CONTENTS

Message from the Director 5 Cardiovascular Imaging 27 Letter from Dr. Newman and Dr. DiPaola 6 Device Clinic 29 Research Priority Areas 8 Heart Station 30 Patient and Family Advisory Council 10 Echocardiography 32 Nursing 11 Awards and Accreditations 34 Patient Story: Mark Meade 14 By the Numbers 36 Interventional Cardiology 16 Affiliate Network 41 Structural Heart Program 17 Education 42 Heart Rhythm Program 18 Research 44 Advanced Heart Failure and Transplantation 20 Leadership and Faculty 45 Women’s Heart Health 22 Clinical Trials 48 Cardio-Oncology 24 Publications 51

Cardiac Rehabilitation 25 Philanthropy 64 4 | UK Gill Heart & Vascular Institute | 5

ADVANCING AND TRANSFORMING HEART CARE

As Director of the UK HealthCare Gill Heart & Vascular now exceeding 100 TAVRs a year, and anticipate these Institute, I am a deep believer in our academic health numbers will grow with the addition of new faculty, center’s tripartite mission: to care for the citizens including Dr. Naoki Misumida, who joined us after of the Commonwealth, support the advancement of completing structural training at Mayo Clinic. ideas through our faculty research, and develop future healthcare leaders who will use their knowledge as a We were fortunate to recruit Dr. Emma Birks, who is force for good. internationally recognized for her work in heart failure, to be the Director of our Advanced Heart Failure, As we look back on the past year, I want to highlight a Transplant and VAD section. She has worked to expand few events and achievements at Gill Heart & Vascular the team, with the addition of Dr. Netti Reddy and Dr. Institute that have furthered that mission: Gaurang Vaidya, and the program’s reach across the state. Dr. Andrew Kolodziej, MD, stepped into the role of In April 2019, we hosted providers from around our Medical Director of Heart Transplantation. Kentucky at our annual symposium, called “The Very Latest in Cardiovascular Medicine and Surgery.” This Under Dr. Aaron Hesselson’s leadership, our electro- event covered a broad spectrum of topics, from vascular physiology program continues to grow with the addition and cardiac surgery to updates in diabetes and opioid of two new faculty: Dr. Kristen Ellison and Mohammed abuse as they pertain to cardiovascular care. Al-Yafi.

We provided over 500 hours of education to clinicians Finally, we are proud to announce the two newest and scientists through events such as the Gordon Hyde members of our Affiliate Network: Lake Cumberland Lectureship, the Whayne Symposium, the Healthy Regional Medical Center and Ephraim McDowell Hearts for Women Symposium, the Flowers and Horan Regional Medical Center. Through this network of Lectureship, and courses like Echocardiography community providers, we are able to bring advanced Scanning and Review, Foundations of ECLS, Hands-On care to patients across the Commonwealth. TAVR, and many more. I am proud to share the work of my colleagues, but We are training our largest-ever cohort of fellows in the transformative work we do every day at Gill Heart cardiology, cardiac surgery and vascular surgery, and & Vascular Institute would not be possible without our team authored more than 230 peer-reviewed publica- the amazing healthcare community that we partner tions, and more than 15 books and/or chapters. with. With the help of our partners, we can continue to improve the lives of Kentuckians and make our In March, our team traveled to the annual meeting of Commonwealth a healthier place. American College of Cardiology (ACC.19), where we gave more than a dozen presentations. Our own Dr. Khaled Please feel free to connect with me via email at susans- Ziada was inducted as the governor of the Kentucky [email protected] to discuss our work further, or to share Chapter of ACC, and Craig Beavers, PharmD, was advancements happening in your organization. inducted as the incoming chair of the CV Teams council. We hope that through these leadership positions, we Sincerely, will continue to impact the level of care in Kentucky and beyond. Susan S. Smyth, MD, PhD, FACC Director, Gill Heart & Vascular Institute In 2019, our structural heart team, led by Dr. John Chief, Division of Cardiovascular Medicine Gurley, performed our 400th TAVR procedure. We are 6 | UK Gill Heart & Vascular Institute UK Gill Heart & Vascular Institute | 7

TACKLING KENTUCKY’S BIGGEST KILLER WITH HIGH-IMPACT SOLUTIONS

Here at the University of Kentucky, our academic Points of Pride health system, led by UK HealthCare and the College For the fifth year in a row, U.S. News & World Report of Medicine, is laser focused on a mission that can be ranked us the number one hospital in Kentucky. We are summed up simply: helping Kentucky be healthier. proud of this great honor, but we will not be complacent.

This moral imperative guides our expert care, our Throughout the years, the Gill Heart & Vascular research, the way we educate the state’s next genera- Institute has been an ever-increasing point of pride for tion of health professionals and our outreach. At UK the University of Kentucky, providing unparalleled care HealthCare and the College of Medicine, we are working to patients and pursuing groundbreaking research that in both lab and clinic to improve the state of the heart. has propelled us onto the national stage. Cardiovascular research is now a research priority area for UK The State of the Heart in Kentucky HealthCare and the College of Medicine, and colleges Cardiovascular disease is the number one cause of death across UK are coming together to impact change in this in Kentucky and the nation. Kentucky’s age-adjusted sphere, as you will read later on in this publication. death rate from diseases of the heart outpaces even the death rate in cancer[1]. The Gill Heart & Vascular Institute Affiliate Network has worked tirelessly in the last few years to expand our The high rate of death from heart disease—coupled footprint across the state. More than ever, those in the with our growing concern regarding disparities in risk, farthest corners of our commonwealth can access our access to care and outcomes—have factored into a bold first-rate care. new five-year strategic plan. 2020 has presented unforeseen challenges. We have Even as the state of cardiovascular services at UK needed to be nimble, proactive and tenacious. Our teams HealthCare continues to advance, there is much work continue to provide a human connection that patients to do to make an impact on such a deeply entrenched need as they navigate illness and fear. We are proud and problem. honored by the courage, dedication and leadership they so naturally provide to patients and each other every Cardiovascular Disease Considered a High-Impact Area day. Five key strategic objectives will impact the Gill Heart & Vascular Institute and our cardiovascular services in Through it all, we have demonstrated that we are still areas of quality, safety, innovation, patient experience, the best in Kentucky, and for Kentucky. health care equity and relationships built through outreach, affiliations and partnerships. Mark F. Newman, MD We will continue to develop high-impact areas such Executive Vice President for Health Affairs as cardiovascular services as part of an ambulatory UK HealthCare strategy that seeks to prioritize by need and by our ability to make a significant contribution to improved Robert S. DiPaola, MD health within the university, our community and the Dean, College of Medicine Commonwealth. University of Kentucky

[1] National Vital Statistics Reports, Vol. 68, No. 9, June 24, 2019, Centers for Disease Control and Prevention. https://www.cdc.gov/nchs/data/nvsr/ nvsr68/nvsr68_09-508.pdf 8 | Research Priority Areas Research Priority Areas | 9

TRANSFORMING TOMORROW BY FOCUSING ON KENTUCKY’S CHALLENGES

University prioritizes cardiovascular research to benefit Kentuckians across the Commonwealth

In an effort to mobilize its most reach,” explained Susan S. Smyth, Vice President for Research and powerful research assets, combat MD, PhD, FACC, Director of the the broader campus-wide CVD some of the state’s biggest health Gill Heart & Vascular Institute and research community. Together, disparities, and benefit the citizens Co-Director of this RPA initiative. they will work to ensure that the of the Commonwealth and beyond, “UK has a prominent and nation- RPA investment in CVD research a new initiative by UK Research has ally recognized cardiovascular further enhances UK’s national and prioritized cardiovascular research, research group that enjoys sub- international reputation, increases along with five other health sectors stantial funding from the National the portfolio of extramurally across the University. And the Institutes of Health, the American funded cardiovascular research, research teams at the Gill Heart Heart Association, pharmaceutical provides an inclusive campus-wide & Vascular Institute and the Saha and device companies, and more.” environment for productive faculty, Cardiovascular Research Center are facilitates trainee experience, answering the call. CVD was also selected because of and promotes CVD research and its major impact across the state. innovation. The University of Kentucky This group of diseases, which Research Priorities Initiative is a includes heart attack, heart failure, “To have a thriving research enter- long-term strategic plan to invest in aortic aneurysms, and peripheral prise is a huge benefit to the clinical the university’s strongest existing vascular disease, is the leading enterprise,” said Dr. Daugherty. and emerging research areas. This cause of death in the United “It means people are being kept effort has multiple goals: increasing States[1], as well as in Kentucky. informed by the most contemporary funding, garnering more complex/ [2] Four of the RPAs—CVD, cancer, findings in that field, and if patients multidisciplinary grants, reducing diabetes and obesity, and substance are willing and want to, they can the burden of disease in Kentucky, abuse disorder—are well-known also be involved in cutting-edge making a statewide economic statewide health disparities. research at our institution.” impact, and recruiting more Research efforts for all four will researchers to the University. Along be housed in the new Healthy “To have a thriving research with cardiovascular disease (CVD), Kentucky Research Building, enterprise is a huge benefit the University’s research priority bringing together multidisciplinary to the clinical enterprise.” areas (RPAs) include cancer, research teams and allowing them - ALAN DAUGHERTY, PHD, DSC diabetes and obesity, energy, to collaborate closely toward the neuroscience, and substance abuse RPA initiative. disorder. [1] Dr. Smyth co-directs the RPA Centers for Disease Control and Prevention. Leading Causes of Death (U.S.). https://www. “These priority areas were iden- with Alan Daugherty, PhD, DSc, cdc.gov/nchs/fastats/leading-causes-of- tified based on existing areas of Director of the Saha Cardiovascular death.htm. Accessed April 17, 2020. [2] strength, as determined by external Research Center. Dr. Smyth . Centers for Disease Control and Prevention. Stats of the State of Kentucky. https://www. funding and research scholarship, and Dr. Daugherty will serve as cdc.gov/nchs/pressroom/states/kentucky/ sustainability, and cross-campus liaisons between the Office of the kentucky.htm. Accessed April 17, 2020. 10 | Patient and Family Advisory Council Nursing | 11

COOKING FROM THE HEART EVERY CARDIAC PATIENT,

Cardiovascular Patient and Family Advisory Council crowd-sources EVERY TIME recipes to help new heart patients How the cardiovascular nursing staff keeps Gill Heart & Vascular In February of 2017, the Cardi- For some families, this can be a cardiac diagnoses as they adjust ovascular Services Patient and major shift as they avoid dishes their lifestyles. Institute running around the clock Family Advisory Council (CV PFAC) heavy in saturated fats, trans fats, was launched at UK HealthCare. sodium and sugar. Filled with recipes for all tastes, Gill Heart & Vascular Institute is an over into the bedside teams, who said Kim Blanton, MSN, MHA, RN, work throughout the hospital. Dedicated to improving partner- along with helpful tips and suggest- intricate network of units, patients, NE-BC, Enterprise Director for clinicians, and procedures, all Infection Prevention and Control. ships between clinicians, patients, Cardiac diagnoses change ed substitutions, “The New Normal focused on providing excellent Whether they’re working through “The nurses here are exceptional and families, this group meets Cook Book” is a resource for new the way patients and patient care, every day. Central to staffing shortages in specific and elite, and they go above and monthly with the interdisciplinary cardiac patients from people who families live, long after they that effort is the nursing staff: a specialty areas, helping train beyond to care for their patients” healthcare team to improve quality, have traveled the same journey. leave the hospital. team of 360 highly-trained, dedicat- new cardiovascular nurses, or safety and service for cardiovascu- As these patients learn how to live ed and specialized nurses providing finding innovative ways to address “There is a pride that comes lar patients. heart-healthy lives, the recipes and That period of adjustment is one exemplary care to patients and challenges that come between the information within the cookbook with working in a high that many of the families and families. team and the best patient care, In those council meetings, facili- offer easy ways to adjust—without acuity unit.” patients who have worked with the leadership team is a constant tators heard a consistent message sacrificing flavor or nutrition. - KIM BLANTON, MSN, MHA, RA, NE-BC the cardiac team at Gill Heart & Many times, cardiovascular source of support, guidance, and from their advisors: cardiac diag- nurses go to the patient, rather expertise. Vascular Institute are familiar Unit Highlight: Cardiovascular noses change the way patients and than the patient coming to them. with. Building off of that shared ex- Progressive Care families live, long after they leave They are available to provide care Training and Education perience, the CV PFAC was inspired Cardiovascular care at Gill Heart the hospital. Many of those changes in any location throughout the Nurses in the cardiovascular to create a cookbook of heart- & Vascular Institute includes a involve diet—adding heart-healthy, hospital—for instance, routinely service line care for a special healthy, crowd-sourced recipes to number of separate units dedicated nutrient-rich meals to daily menus. assisting physicians in performing population of patients that can have help patients and families with new to caring for specific patient bedside cardioversions or ECMO up to 13 different devices—a level populations. One such unit is the cannulations anywhere in the of complexity and acuity un- Cardiovascular Progressive Care hospital. The cardiovascular team matched elsewhere in the hospital. Unit (CV Progressive): an interme- has continued to work on improving Cardiovascular care requires diary step between the ICU and an quality care for some of the sickest specialized training in several acute care floor. The patients on this patients, from all corners of the devices and protocols, including floor require a high level of skilled Commonwealth and beyond. The ventricular assist devices (VAD) and “The New Normal Cook Book” will be available nursing care and surveillance, but team is constantly focused on extracorporeal life support (ECLS). for new cardiac patients as they prepare to are more stable than patients in the return home. decreasing hospital-acquired ICU. The nurse-to-patient ratio on conditions and finding innovative Cardiovascular ICU (CVICU) the CV Progressive unit is typically ways to provide safe, quality care nurses undergo even more rigorous 1:3 or 1:4, depending on patient to all patients. training, involving orientation, “boot camp,” fellowship classes, acuity level. Nursing Leadership clinical education training, and CV Progressive patients typically The cardiovascular nursing leader- direct mentorship to build rela- include people recovering from pro- ship team sets the standard for all tionships with experienced nurses. cedures like cardiac catheterization nurses on the unit: exemplary care Regular additional training in and/or intervention, heart or lung for every patient, every time. That the simulation lab, which cardio- transplants, or placement of a Left standard requires a collaborative vascular nurses do twice a year, Ventricular Assist Device (LVAD), approach, coming together to solve helps keep nurses’ skills sharp and as well as numerous other major challenges and care for patients. prepared for any scenario. cardiovascular surgical procedures. The leadership team works to A typical day for a CT Progressive assure a cohesiveness among their “There is a pride that comes with nurse consists of routine nursing own team—an impact that carries working in a high acuity unit,” 12 | UK Gill Heart & Vascular Institute Nursing | 13

care, dispensing medication, Marc Manley, MSN, RN, NE-BC, heart conditions can be kept in the Unit Highlight: Progressive the top 25 percent in patient satisfac- Photo caption pa volori tecumqu atatem quo checking patient devices, changing Patient Care Manager of the CV labor and delivery unit, while being Telemetry Unit tion, as benchmarked against other temporrovit, nesciatem. Et ut dolo vellaudaes eumquam volest porehen debist, optatio dressings, coordinating testing, Progressive Unit. “The nursing monitored by this team. For some thoracic surgery and academic medical centers across the ratque perum facipsape pedis con nis delliatur and assuring that therapies like team members on this unit have set cardiac catheterization lab patients, nation. am, nulpa consequibus. physical and occupational thera- a high bar for the quality nursing The work of the Central Monitoring the right care can mean skipping pies are completed. care they deliver, and pride them- Station is a collaboration between a stay in the ICU post-surgery and The cardiovascular nursing team, selves in the deeply personal and the technicians and staff on the moving directly into the progressive across all units, is proof of UK Due to the acuity of this patient compassionate relationships that floor. The result: more attention on care unit. That care comes from HealthCare’s dedication to excep- population, staff in the CV they establish with their patients.” cardiac patients throughout the the Progressive Telemetry Unit tional patient care. In their training, Progressive unit are highly hospital. Central Monitoring Station in Pavilion H, led by Patient Care their expertise, their service, and trained. 90 percent of the 61 nurses The team has received numerous technicians can observe patients’ Manager Lauren Stroud, MBA, MSN, their commitment to each other, they in the unit have a BSN or MSN, and DAISY Award nominations for ex- monitor output in real time and RN, NE-BC. Her team is specially are vitally important to Gill Heart & are in the Nursing Professional traordinary nursing, and recently can offer floor staff assistance if trained to care for cardiac patients Vascular Institute patients, families, Advancement program. All 34 won the UK HealthCare “Zero Hero” needed—for example, technicians and their specific devices and clinicians, and staff, across all technicians that work on this floor Award. This award recognizes can see if a patient is taking off their implants, particularly patients corners of the hospital. have CAN or sRNA certification. the unit team for their clinical monitor leads, and can alert the floor who have received a transcatheter inquisitiveness, demonstration and staff in that patient’s unit, no matter aortic valve replacement (TAVR) or Photo caption pa volori tecumqu atatem quo Continuing education is a priority application of evidence and best where they are. No other hospital WATCHMAN device. temporrovit, nesciatem. Et ut dolo vellaudaes for CV Progressive staff. The practice, innovation and dedication in Lexington offers a nursing and eumquam volest porehen debist, optatio team is responsible for annual CV to a no-harm environment. monitoring model this complete and The highly-trained group is commit- ratque perum facipsape pedis con nis delliatur am, nulpa consequibus. competency exams, LVAD training, comprehensive. ted to delivering top-notch care—and advanced pharmaceutical compe- Unit Highlight: Central Monitoring their patients have noticed. The team tencies, EKG testing and equipment Station The Central Monitoring Station team has received superior scores on their training. Many nursing staff in The Central Monitoring Station, led has been recognized with the UK Employee Engagement Surveys for the CV Progresssive Unit are also by Tami Neal, MSN, RN-BC, NE-BC, Quilt of Teamwork Award for Nursing the past three years, and has also considered wound care super-us- is a unique team of 14 nurse Support, which will hang in their de- remained free from a CAUTI for the ers, since most of their patients coordinators and 70 technicians partment until it is awarded to a new past six years. have had surgical procedures or who help monitor patients with team next year during Nurses Week. device placement. cardiovascular issues throughout The quilt represents the powerful Two of the team’s nurses, Marco the hospital. By monitoring collaboration and genuine relation- Gomez and Megan DeHart, recently “What sets this floor apart from telemetry orders from patients ships between nurses, patients, and received DAISY Awards. The unit as a the other floors is the advanced across the hospital, the Central stakeholders—all coming together to whole recently received the Office of nursing knowledge that is Monitoring Station allows patients promote and restore wellness among Patient Experience Award: a banner required to care for this higher to remain in their own units—for the patients served by the Central given at the end of each quarter to acuity patient population,” said example, pregnant women with Monitoring Station team. departments or clinics that score in 14 | UK Gill Heart & Vascular Institute Patient Story: Mark Meade | 15

“I’M THE LUCKIEST MAN ALIVE.”

How a stress test saved patient Mark Meade’s life

“My daughter said, ‘Dad, you had “I ran out to grab every person I Their second nurse, Natasha, a heart attack and you’re at UK could find,” said Jennifer. “They focused on taking care of both Mark HealthCare.’ The night before, came right away and they took and his family. Despite being eight Kentucky had played Duke, and I care of him. Honestly, if he wasn’t months pregnant and caring for a asked, ‘Who won the ballgame last there, if he was anywhere else, he number of patients, she found time night?’ She said, ‘Dad, you don’t wouldn’t have made it. They ran to get to know Jennifer and Mark’s want to know.’ I said, ‘Okay. Who to me, they ran to him. There’s daughters, keeping them updated won the Kentucky/Georgia game probably 20 people that just cared while providing the intensive on Saturday?’ She said, ‘Let’s talk for both of us and kept me informed. care that ECMO patients require. about your recovery instead.’” We had angels there that night.” “Nobody is okay in that situation,” Natasha said. “I can only imagine Mark Meade’s heart has been “If he was anywhere else, he what that would be like for me, through a lot. For 50 years, so I always try to make sure I’m plaque had been building up in wouldn’t have made it.” comforting my patient’s family his arteries. He spent eight years - JENNIFER MEADE as much as I’m trying to help my working with Dr. Tom Whayne at patients.” Gill Heart & Vascular Institute, For the next nine hours, more going from “1% of the worst lipid than a dozen doctors, nurses and “They said that’s their job to take profiles in the country to 1% of the anesthetists worked to keep Mark care of Mark, but it’s also their job best.” But those decades of damage alive. Dr. Khaled Ziada, who had to take care of the family,” Jennifer had taken a toll—one that Mark been running Mark’s stress test, said. “They helped us as much didn’t realize until it was almost stayed on for hours past the end of as they helped him get through too late. his shift to care for Mark, who was everything.” immediately brought into surgery. In the fall of 2018, at Dr. Whayne’s After doctors repaired his heart, “Jessica was more on the compas- urging, Mark went into UK Mark was placed on advanced life sionate side with my family, and HealthCare for a cardiac stress test. support—ECMO—while his body keeping them sane,” said Mark. Mark’s wife, Jennifer, came with recovered. He was unconscious for “Natasha was more on the clinical him. Mark had been on the tread- the next six days. side and keeping me alive, but mill for just a few minutes when he they both were really important to “It wasn’t clear cut that when I woke “I tend to appreciate every Mark Meade greets his nurses for the first collapsed—the victim of a massive From the moment Mark lost con- everyone that was with me then.” up that I was out of the woods, so I morning when I wake up and sciousness, both he and Jennifer time since leaving the hospital: Natasha Crain didn’t know if I was going to see my heart attack that had been building (pictured) and Jessica Turner. my eyes open in bed and I’ve in his arteries for years. “I think I were cared for around the clock Mark had gone in for his stress test birthday, which was a week later. was clinically dead at that point,” by members of the UK HealthCare on Friday. He woke up the following I also didn’t know if I was going got one more day. I feel like Mark said. team, becoming especially close Wednesday, unsure of where he to be with family at Thanksgiving, every day’s a bonus day at this with two nurses. One, Jessica, was was or what he’d been through, Christmas and New Year’s. But here point.” nearby when Mark collapsed, and but eager to go home. While he was I am today. I tend to appreciate every Mark had been on the tread- - MARK MEADE she rushed to take care of Jennifer. recovering his strength, a friend of morning when I wake up and my eyes mill for just a few minutes “His wife was horrified—he col- his—a physician himself—came to open in bed and I’ve got one more day. when he collapsed—the lapsed on the treadmill, they were visit, and was shocked by Mark’s I feel like every day’s a bonus day at victim of a massive heart doing CPR on him, it was very very alertness. “He said, ‘What you went this point.” attack that had been scary. I helped get their family and through on Friday—you should the chaplain there, and I stayed have no brain function left.’” building in his arteries for with her—I mediated between what Knowing how serious his condition years. was happening, held her hand, was made Mark even more thankful updated her. I was in the right place to be back home with his family in at the right time.” time for the holidays. 16 | Interventional Cardiology Structural Heart Program | 17

COMPLEX CONDITIONS. RAPIDLY REPAIRING INNOVATIVE SOLUTIONS. THE HEART

Interventional Cardiology Team offers the latest advances for Structural Heart Program performs leading-edge procedures complex cardiac patients to get patients home faster

The interventional cardiologists at involvement in advanced research experts in the fields of cardiac Structural heart issues can run the UK HealthCare has been a pioneer Structural Heart Program providers Gill Heart & Vascular Institute are initiatives, the latest treatments imaging, heart failure, trans- gamut, ranging from genetic heart in transcatheter heart valve work with each patient to choose highly experienced and nationally in cardiovascular medicine are plantation, mechanical support, defects to problems developed later interventions for more than 25 the most fitting treatment option for recognized in various areas of available to Kentuckians as soon as pulmonary hypertension, platelet in life. Regardless of the specific years. Thanks to that experience, their condition. As experts in the coronary, peripheral, carotid and possible. biology and stem cell research. That condition, though, all require the Structural Heart team is able to latest minimally-invasive approach- structural heart procedures. That collaborative approach benefits an expert approach to diagnose, offer patients a number of inno- es and interventions, the team is experience allows them to provide The latest treatments in both patients and physicians and repair, and treat. That’s where the vative, minimally invasive heart proud to offer many leading-edge Structural Heart Program at the valve procedures, depending on the procedures that are less risky comprehensive care for even the cardiovascular medicine are helps find innovative solutions for Gill Heart & Vascular Institute specifics of their condition. One of and ensure a faster recovery than most complex and advanced cardiac available to Kentuckians as even the most complex conditions. problems. comes in. With extensive experience these procedures, transcatheter traditional open-heart surgery. 85 soon as possible. in diagnosing and treating all aortic valve replacement (TAVR), percent of Structural Heart patients The team’s catheterization labora- Photo caption pa volori tecumqu atatem quo types of structural heart disease, is a minimally invasive procedure do not require anesthesia for their When dealing with complex medical temporrovit, nesciatem. Et ut dolo vellaudaes tories are equipped with the most including aortic stenosis, mitral for treating aortic stenosis when procedures, and are able to return conditions, patients require the eumquam volest porehen debist, optatio advanced technologies for imaging, ratque perum facipsape pedis con nis delliatur valve regurgitation and stenosis, traditional open-heart surgery is home the same day. contributions of more than one am, nulpa consequibus. cardiac support and advanced tricuspid valve disease, atrial too great a risk for the patient. expert in the field of cardiovascular interventional techniques to septal defects (ASD), and patent medicine. Interventional physicians Photo caption pa volori tecumqu atatem quo provide the appropriate service for foramen ovale (PFO), the Structural UK HealthCare has been a collaborate with other members temporrovit, nesciatem. Et ut dolo vellaudaes all patients, no matter what their Heart team offers expert care for pioneer in transcatheter eumquam volest porehen debist, optatio of the team: nationally recognized their cardiac patients. ratque perum facipsape pedis con nis delliatur needs are. Thanks to the team’s heart valve interventions for am, nulpa consequibus. more than 25 years.

Photo caption pa volori tecumqu atatem quo temporrovit, nesciatem. Et ut dolo vellaudaes eumquam volest porehen debist, optatio ratque perum facipsape pedis con nis delliatur am, nulpa consequibus. 18 | UK Gill Heart & Vascular Institute Heart Rhythm Program | 19

Dr. Aaron Hesselson, a former heart patient himself, is now the Director of KEEPING THE RHYTHM Electrophysiologic Services at Gill Heart & Vascular Institute. Multidisciplinary Heart Rhythm Program brings together experienced team for patients of all ages

The Heart Rhythm Program at Gill including supraventricular tachy- ablation procedure in such patients, Heart & Vascular Institute unites cardia, atrial fibrillation (AF) and and success of AF ablation in a multidisciplinary team to assist ventricular tachycardia. The team patients on ambulatory intravenous with all aspects of arrhythmia also implants pacemakers, includ- heart failure agents. care. Led by Dr. Aaron Hesselson, ing the newest leadless devices, and director of electrophysiologic defibrillators, including the latest Both he and Dr. Ellison are services and a former heart patient subcutaneous devices, as well as implanting advanced devices for himself, this group focuses on providing cardiac resynchroniza- management of congestive heart providing expert, patient-centered tion therapy. failure in patients in whom no care. therapies beyond medicine were Dr. Hesselson and Dr. Kristen previously available. Dr. Ellison The EP team includes cardiac Ellison bring over 50 years of specializes in the latest in pacemak- electrophysiologists, cardiothoracic combined experience in adult er management with “His-bundle surgeons, cardiologists, cardiac cardiac electrophysiology to the pacing,” a progressive approach to anesthesiologists, nurse practi- Gill Heart & Vascular Institute. right ventricular and biventricular tioners and physician assistants, The team’s current efforts are pacing. cardiac device specialists, a nurse particularly focused on managing coordinator, clinical service more complex issues involving AF, Gill Heart & Vascular Institute has technicians, pharmacists, and a congestive heart failure, and alter- an ongoing joint partnership with cardiac research team. nate implantable device strategies. Cincinnati Children’s Hospital to offer electrophysiology services to UK HealthCare’s EP program is one Dr. Hesselson and Dr. Kristen children. Dr. Sean Mohan brings of the highest-volume academic, Ellison bring over 50 years a robust practice to the pediatric research-based programs in of combined experience in electrophysiology population, the Commonwealth. In fact, the adult cardiac electrophys- allowing for a greater availability program saw more than 3,500 of care for the Commonwealth. patients and performed more than iology to the Gill Heart & 900 procedures last year. More Vascular Institute. importantly, the program also exceeds national benchmarks. One procedure the team is currently using for many patients is catheter UK HealthCare’s EP ablation for AF. This procedure, program is one of the which is growing in use and popu- larity, is currently being used with highest-volume academic, a high success rate on patients with research-based programs in concurrent additional heart issues the Commonwealth. such as congestive heart failure. Despite current use, it is unclear With a brand new, state-of-the art to how this aggressive ablation electrophysiology lab, the team’s technique can be performed in even experts have both the knowledge sicker patients. Dr. Hesselson has and the equipment to perform multiple manuscripts in review simple and complex ablations, looking at the stability of the 20 | UK Gill Heart & Vascular Institute Advanced Heart Failure | 21

ADVANCED CARE FOR ADVANCED HEART FAILURE

High-Performing Heart Failure Team offers lifesaving care

With a comprehensive, multidisci- Dr. Emma Birks recently joined the in the Center for Clinical and plinary approach and leading-edge team as the Section Chief of Heart Translational Sciences, as they clinical technology, the Advanced Failure, Ventricular Assist Devices have closely-aligned interests in Heart Failure, Ventricular Assist and Heart Transplantation. She is the mechanisms involved in the Device and Heart Transplant well-known internationally for her reversal of heart failure. Program at Gill Heart & Vascular work in advanced heart failure—in Institute is one of the leading particular for her expertise in The team is expanding further, programs in the country. The work ventricular assist devices and their recruiting Dr. Guarang Vaidya, who and dedication of this team led U.S. ability to recover the human heart, recently completed his advanced News & World Report to score UK even from advanced heart failure. Heart Failure fellowship training HealthCare as “High Performing” at Cedars-Sinai, and Dr. Neeti in heart failure—a score based on Dr. Birks is well-known inter- Reddy, who recently completed her multiple data categories, including nationally for her work in advanced heart failure training at patient survival, volume and more. advanced heart failure—in University of Texas Southwestern That rating is a reflection of the in Dallas. As the Heart Failure team program’s experienced team and particular for her expertise grows, having talented additions skilled approach to patient care. in ventricular assist devices like Drs. Vaidya and Reddy will and their ability to recover allow the program to offer even The Heart Failure team includes a the human heart. more options, care and experience diverse group: certified cardiolo- for patients with advanced heart gists, cardiac surgeons, advanced Since joining the program in conditions. practice nurses, critical care October of 2019, Dr. Birks has also certified registered nurses, skilled been asked to lead the program Heart transplant volume has specialized mechanical support, committee for mechanical circula- remained high at UK HealthCare, heart failure and transplant tory support for the 2021 meeting even during the COVID-19 Intensive Care Unit, a paramedic, a coordinators, as well as specialist of the International Society of pandemic. The team adapted their The wait for a donor heart is perfusionist and an EMT. If needed, Joy Coles, DNP, APRN and Dr. Andrew pharmacists, physical, occupational protocols to maintain patient safety shorter at UK HealthCare than Heart and Lung Transplantation. the surgeon also travels with Kolodziej, MD are two of the many specialists and speech therapists, nutritionists without delaying vital care, and caring for patients in advanced heart failure. She is also playing a leading role in in the surrounding area, as the team, giving patients on this and social workers. This team writing the updated international performed 22 heart transplants well as the national average just in the first half of the 2020 advanced form of life support the very ensures that patients receive not guidelines for the management of calendar year. The wait for a donor wait. best care, as rapidly and safely as only the best treatment for their VAD for the International Society heart is shorter at UK HealthCare possible. individual situation, but the best of Heart and Lung Transplantation than in the surrounding area, as Additionally, the team’s extracorpo- possible experience at a difficult (ISHLT), has written a chapter well as the national average wait. real membrane oxygenation (ECMO) time in their lives. for this year’s ISHLT Monograph The program is also expanding its service continues to grow, renewing on mechanical support, and has outreach clinics and collaboration gold-level Center of Excellence status The Advanced Heart Failure, written the VAD chapter this year with surrounding hospitals to from the Extracorporeal Life Support Ventricular Assist Device for UpToDate—the online resource facilitate more care, closer to home, Organization (ELSO) in 2020. The and Heart Transplant that is most commonly used as a for patients outside the Lexington ECMO team has the ability to travel reference by all junior doctors. area. up to four hours away to transfer Program at Gill Heart & critically ill patients on ECMO to Vascular Institute is one of Dr. Birks collaborates with Dr. Ken UK HealthCare. The team consists the leading programs in the Campbell, Professor of Physiology of a lead nurse with intensive ECMO country. and Cardiovascular Medicine training in the Cardiovascular 22 | UK Gill Heart & Vascular Institute Women’s Heart Health | 23

PROTECTING KENTUCKY WOMEN’S HEARTS

Women’s Heart Health Program is meeting the unique needs of the Commonwealth

Under the direction of Dr. Gretchen Wells, the Gill Heart Pregnant patients with cardiovascular & Vascular Institute Women’s Heart Health Program disease require specific care. continues to grow. The program’s outpatient practice is now available to see patients daily, and the team has The program and its faculty are also involved in several hired a new nurse practitioner and is looking to expand other research initiatives. As a co-investigator in the its faculty next year. Women’s Health Initiative, funded by the National Heart, Lung and Blood Institute, Dr. Gretchen Wells The team’s microvascular testing program also contin- has participated in a number of studies involving the ues to grow, with a number of patients now enrolled in hormonal status of post-menopausal women and the the Department of Defense-funded WARRIOR study for impact of that status on cardiovascular events. The the treatment of microvascular disease. The program’s Women’s Heart Program at UK HealthCare is in the early care of women undergoing potentially cardiotoxic che- stages of an investigator-initiated study of psychological motherapy has grown to the extent that its own program factors influencing cardiovascular disease outcomes. will be launched later this year. The Women’s Heart Health Program has continued to be Given the burden of cardiovascular disease in the active in the wider Lexington and Kentucky community, Commonwealth, the Women’s Heart Health Program providing tailored presentations regarding cardiovas- puts a particular emphasis on prevention. To that end, cular disease to women in the area. While the COVID-19 patients are offered state-of-the-art testing options, as pandemic brought a halt to in-person presentations, the well as personalized plans for prevention of coronary Women’s Heart Health Program looks forward to con- artery disease. tinuing this work in the future to help empower women across Kentucky to take charge of their cardiovascular Given the burden of cardiovascular disease health. in the Commonwealth, the Women’s Heart Health Program puts a particular emphasis The Women’s Heart Health Program has on prevention. continued to be active in the wider Lexington and Kentucky community, providing tailored Pregnant patients with cardiovascular disease require presentations regarding cardiovascular specific care. The team’s robust cardiovascular disease disease. and pregnancy program, a collaboration with Obstetrics and Gynecology, helps manage the care of these patients during pregnancy and postpartum. UK HealthCare Photo caption pa volori tecumqu atatem quo temporrovit, nesciatem. Et ut dolo vellaudaes has participated in the multicenter Investigations of eumquam volest porehen debist, optatio Pregnancy Associated Cardiomyopathy (iPAC), and ratque perum facipsape pedis con nis delliatur plans to participate in the next phase of this investi- am, nulpa consequibus. gation, which involves novel treatments of peripartum cardiomyopathy. 24 | Cardio-Oncology Cardiac Rehabilitation | 25

WHERE CANCER AND CARDIO INTERSECT ONE STEP AT A TIME

Growing Cardio-Oncology Program aims to help cancer patients Positive outcomes show impact of Cardiac Rehabilitation Program prevent cardiac side effects For many patients with cardiovas- patient. The program is designed As patients participate in With increasing survival from The Cardio-Oncology Program cular issues, managing those condi- to help patients improve their the program, they work cancer and a progressively aging exists to help this growing patient tions requires more than medicine. health and help them recover towards regaining strength, population, the incidence of cardio- population. The program aims to The team at Gill Heart & Vascular from conditions like myocardial preventing conditions from vascular disease in cancer patients ensure better outcomes for patients Institute’s Cardiac Rehabilitation infarction, coronary artery disease, Program gives patients the tools, heart failure, peripheral artery worsening, reducing future is on the rise. In fact, survivors of with cancer and cardiac issues, risk, and improving their cancer are more likely to die from a both by providing earlier detection strategies, exercises and monitor- disease, angina, cardiomyopathy, health and quality of life. cardiovascular complication than of cardiac-toxic side effects from ing they need to help live healthier certain congenital heart diseases, from cancer recurrence. That’s where cancer treatments and by prevent- lives. The team offers state-of-the- coronary artery bypass surgery, The Cardiac Rehabilitation the Gill Heart & Vascular Institute’s ing, reducing or reversing cardiac art diagnostic evaluation, treatment angioplasty and stents, heart or Program is nationally accred- Cardio-Oncology Program comes in. damage whenever possible. The team and management of conditions lung transplant, heart valve repair ited through the American also monitors patients with potential related to cardiac disease, including or replacement, and pulmonary Association of Cardiovascular Cardio-oncology is a growing disci- cardiac issues while they’re receiv- diabetes, blood pressure, medica- hypertension. and Pulmonary Rehabilitation pline that focuses on the treatment ing treatments. tion adherence, home exercise, diet, (AACVPR). Program staff are and prevention of heart conditions and tobacco cessation. Participation in cardiac re- actively involved in the national in patients who are or have been As the field of cardio-oncology habilitation involves exercise (AACVPR) and state organizations treated for cancer. Chemotherapy, grows, the team hopes to lead and For many patients with training, emotional support, (Kentucky Cardiopulmonary immunomodulatory therapy, and participate in research studies to cardiovascular issues, and education. Rehab Association, KCRA). Two radiation therapy can have deadly contribute to this important disci- managing those condi- staff members currently hold cardiovascular side effects. These pline. The ultimate goal: to eliminate Participation in cardiac rehabili- tions requires more than the positions of Immediate Past treatments can place patients at cardiac disease as a barrier to tation involves exercise training, medicine. President and Treasurer of the state risk for a variety of cardiovascular effective cancer therapy for patients emotional support, and education organization, and are an integral complications including heart across the Commonwealth, and about lifestyle changes to reduce The Cardiac Rehabilitation Program part of planning for the annual failure, myocarditis, coronary artery across the globe. heart disease risk. Patients can can accommodate up to 16 patients conference. This year, three UK disease, peripheral vascular disease, meet with a dietician to help simultaneously, and is located HealthCare employees were honored thromboembolism, pericardial identify ways to eat a heart-healthy at University of Kentucky’s Good as speakers at KCRA: Dr. Gretchen disease and valvular heart disease. diet and keep a healthy weight, Samaritan Hospital. The program’s Wells, Dr. Rajan Joshi, and Shorus Cancer patients receiving therapy or they can work with a tobacco expert team includes exercise phys- Minella, RD. with known cardiac risks require iologists, an exercise specialist, treatment specialist for tobacco close monitoring during and after RNs, a clinical services technician cessation. Successful completion of treatment, as complications can and a clinical dietician—all trained the program is based on decreases occur during treatment or years and equipped to help cardiac in blood pressure, self-reported later. patients heal and get healthier. levels of depression, tobacco The program offers leading-edge cessation and increases in six-min- The ultimate goal: to elim- technology for the assessment and ute walking distance. As patients inate cardiac disease as a treatment of patients referred for participate in the program, they barrier to effective cancer rehabilitation. work towards goals of regaining therapy for patients across strength, preventing conditions from worsening, reducing future the Commonwealth. Cardiac rehabilitation is an outpatient program of exercise and risk of heart problems, and improv- education, customized for each ing their health and quality of life. 26 | UK Gill Heart & Vascular Institute Cardiovascular Imaging | 27

A BETTER VIEW

Advanced Cardiac Imaging Team provides wide range of services at UK HealthCare and beyond

Gill Heart & Vascular Institute is UK HealthCare patients. FFR high-quality imaging capabilities one of Kentucky’s major centers for originated as an invasive method to providers throughout Kentucky, advanced cardiovascular imaging, of assessing whether a blockage increasing access to quality care for with more than 1,500 cardiac CTs is limiting blood flow to the heart. cardiovascular patients across the and cardiac MRIs performed over Thanks to advances in technology, Commonwealth. past year. In addition to cardiac these types of assessments can MRI and CT imaging, the program now be performed non-invasively The team also provides also performs advanced techniques with coronary CT angiography. Gill high-quality imaging capa- that few other centers in the region Heart & Vascular Institute was the bilities to providers through- can match, including: first center in the state to offer this out Kentucky. innovative non-invasive technique. • Stress cardiac MR Perfusion Imaging to Gill Heart & Vascular Photo caption pa volori tecumqu atatem quo detect obstructive coronary temporrovit, nesciatem. Et ut dolo vellaudaes Institute was the first center eumquam volest porehen debist, optatio artery disease in the state to offer this ratque perum facipsape pedis con nis delliatur innovative non-invasive am, nulpa consequibus. • Determination of Myocardial Perfusion technique. Reserve Index to assess for The Advanced CV Imaging Program microvascular disease has also participated in various imaging multi-center research Performing diagnostic • trials, including the PRECISE Trial cardiac MRI on patients (Prospective Randomized Trial of with pacemakers/ICDs by the Optimal Evaluation of Cardiac suppressing artifacts from Symptoms and Revascularization), these devices which is designed to determine the optimal cardiac imaging pathway Calculating myocardial • in the assessment of patients extracellular volume to Photo caption pa volori tecumqu atatem quo with chest pain for obstructive temporrovit, nesciatem. Et ut dolo vellaudaes assess for diffuse fibrosis eumquam volest porehen debist, optatio coronary artery disease. Gill Heart in the heart ratque perum facipsape pedis con nis delliatur & Vascular Institute was one of only am, nulpa consequibus. 13 centers in the US that met strin- • Advanced 3D processing of gent criteria to be included in the CT/MR images for Stress CMR Perfusion Imaging in procedural planning the United States study (SPINS), and is one of just 20 sites in the world • Fractional Flow Reserve participating in the International (FFR) with CT Congenital Cardiovascular CT Registry. One of those advanced imaging methods, fractional flow reserve In partnership with the Gill Heart (FFR), is an example of how & Vascular Institute Affiliate advanced technology benefits Network, the team also provides 28 | UK Gill Heart & Vascular Institute Device Clinic | 29

LIFESAVING TECHNOLOGY. EXPERT CARE.

The Device Clinic helps patients adjust to life with implantable cardiac devices

Approximately 2,700 patients at UK The Device Clinic remotely HealthCare rely on cardiac implant- Photo caption pa volori tecumqu atatem quo monitors approximately 1,600 temporrovit, nesciatem. Et ut dolo vellaudaes able electronic devices (CIEDs) like patients, with electrophysiol- eumquam volest porehen debist, optatio pacemakers, defibrillators, and im- ratque perum facipsape pedis con nis delliatur plantable loop recorders. The Device ogists and advanced practice am, nulpa consequibus. Clinic at the Gill Heart & Vascular providers reviewing remote Institute serves these patients, from transmissions. the day of the implant onward. In addition to remote monitoring From their first visit the Device surveillance and support, the Device Clinic for a post-operative follow-up Clinic provides perioperative device to assess their incision, patients management recommendations work closely with clinic team and pre-MRI CIED evaluation and members to learn about their programming recommendations. new device. Device Clinic staff Device Clinic staff members also members help patients enroll their provide device interrogation support newly-implanted devices in the for the Cardiology Clinic. vendor database, then coordinate the delivery of any required remote As more cardiac patients receive monitoring equipment. lifesaving CIED implants, the team at the Device Clinic will continue The clinic remotely monitors to serve them, offering the care and approximately 1,600 patients, with expertise necessary to help patients electrophysiologists and advanced learn to live with their new devices. practice providers reviewing remote transmissions, reporting significant findings to the provider, and following up with patients to discuss symptoms and making any programming changes the provider deems necessary. 30 | UK Gill Heart & Vascular Institute Heart Station | 31

STANDING AT THEIR STATION

The UK HealthCare Heart Station team offers cardiac services to help patients and staff

When it comes to heart care, timely treatment is vital. In addition to ECGs, the cardiopulmonary technicians The staff of UK HealthCare’s Heart Station is a key part who work at the Heart Station apply and analyze Holter of that care for cardiac patients at at the Gill Heart & and event monitors to observe heart rate and rhythm Vascular Institute. in cardiac patients over an extended period of time. In 2019, the team applied approximately 1,800 monitors, The Heart Station offers a variety of rapid cardiac care which were observed and interpreted by a team of services, including electrocardiograms (ECGs) and attending cardiologists. extended observation and analyses of patient heart rates. Often, these services are performed in cooperation In September of 2019, the Heart Station was dedicated to or consultation with other aspects of cardiovascular Drs. Nancy Flowers and Leo Horan, who were an integral care at the Gill Heart & Vascular Institute. The Heart part of the Gill Heart & Vascular Institute. Drs. Flowers Station team is also responsible for training new nursing and Horan were also members of the Association of care and respiratory therapy staff members to perform University Cardiologists, a national honor bestowed to 12-lead ECGs. less than 1% of cardiologists since 1961 for important contributions in science and teaching. The husband-and- The team performed more than 5,500 ECGs wife team ran the Heart Station for many years, with in 2019, for both walk-in and pre-operative Dr. Flowers continuing to read EKGs remotely after the patients. couple moved to New Mexico in 2009. The vital work of the Heart Station team continues to be carried on in The team performed more than 5,500 ECGs in 2019, their honor. for both walk-in and pre-operative patients. Heart Station staff perform outpatient electrocardiograms In September of 2019, the Heart Station was on a walk-in basis at their locations in the Gill Heart & dedicated to Drs. Nancy Flowers and Leo Vascular Institute in Chandler Hospital’s Pavilion G, and Horan, who were an integral part of the Gill at the Good Samaritan office on Maxwell. Team members Heart & Vascular Institute. also perform ECGs for the Cardiac Catheterization Lab and Gill Heart & Vascular Institute Imaging. Their work is prolific: in 2019 alone, the team performed approxi- mately 1,500 ECGs in these locations. The Heart Station also supports the Pre-Operative Testing Clinic, provid- ing timely services for patients requiring pre-operative clearance. For these patients, the Heart Station team performed approximately 4,100 ECGs in 2019.

Team members also perform ECGs for the Cardiac Catheterization Lab and Gill Heart & Vascular Institute Imaging. The newly-dedicated Heart Station provides vital services to patients and staff throughout UK HealthCare. 32 | UK Gill Heart & Vascular Institute Echocardiography | 33

GIVING EXPERTS A BETTER VIEW Echocardiography Lab continues a tradition of leadership

For decades, the Gill registered nurses who assist with valvotomy for mitral stenosis, Heart & Vascular Institute conscious sedation, cardioversions, paravalvular prosthetic leak Echocardiography (Echo) Lab has contrast echo and pharmacologic closures, ASD and VSD closures, led the state in the advancement of stress testing. TAVR, pericardial drainage, cardiac echocardiography technology. In biopsy, as well as insertion and 1974, the University of Kentucky The physical footprint of the evaluating ECMO and LVAD devices. purchased one of the first available Echo Lab has also dramatically The echo imaging performed in the M-mode machines, allowing expanded. It currently includes catheterization labs and operating University to offer cardiac ultra- an inpatient location in Pavilion rooms during these procedures sound imaging to its patients. After A of Chandler Hospital, an helps guide the process as it is performed by the interventional having been the first in the state to outpatient lab in the Gill Heart team. use spectral and color flow Doppler & Vascular Institute at Chandler (1985) to assess valve stenosis and Hospital, a lab within the Good ACHD involves evaluating adults regurgitation, the Echo Lab pio- Samaritan Cardiology Clinic space for congenital heart defects, or neered the use of transesophageal at Maxwell, and an exam room in following up with patients with echo and stress testing with echo the UK Comprehensive Breast Care such defects. This is a highly imaging in the late 1980s. In 1999, Clinic. These locations, as well as specialized clinical area that the lab became the first in Kentucky the increase in portable bedside requires additional training. The to be accredited by the ICAEL—a exams, has made a major difference Echo Lab team collaborates with national accreditation it has in efficiency as well as patient the Pediatric Echo Lab staff to maintained ever since. convenience. image and interpret the findings of these complex patients. Thanks The Echo Lab pioneered the The UK HealthCare reading service to this collaborative approach, the use of transesophageal echo has expanded the virtual foot- University has been a leader in the and stress testing with echo print—and the overall impact—of region for ACHD patient care. imaging in the late 1980s. the Echo Lab. By electronically networking with affiliated The Echo Lab group takes tremen- hospitals, the team can interpret dous pride in leading the way for Michelle Bay, RDCS, FASE, the remotely-performed studies from education and training. Over the lab’s technical director, is one of Georgetown, Rockcastle, Harrison years, the team’s sonographers and the few echo technologists in the Memorial, Primary Care Centers physicians have trained over 200 state to hold an advanced cardiac of Eastern Kentucky and Clark cardiology fellows in the proper ac- sonographer (ACS) credential. With Regional Hospitals. The team quisition and interpretation of 2D, the growth in demand and volume currently interprets more than 3D, transesophageal echocardio- of studies, the number of sonogra- 17,000 studies per year. gram (TEE), and stress echo studies. phers at the Echo Lab has grown Team members have presented to 17—all of whom are registered The newest areas of growth in lectures and research at the annual through the American Registry for service have been in providing meetings of the American Society of Diagnostic Medical Sonographers imaging for the Structural Heart Echocardiography. For more than and/or Cardiovascular Program and the Adult Congenital 15 years, the Echo Lab has been a Credentialing International. The Heart Disease (ACHD) Program. clinical site for cardiac sonography lab also employs currently nine Structural procedures include the training with St. Catharine College interpreting physician readers, insertion of left atrial appendage and Bluegrass Community and who are also board-certified in this closure devices, MitraClip insertion Technical College. field. The team also includes six for leaky mitral valves, balloon 34 | UK Gill Heart & Vascular Institute Awards and Accreditations | 35

LEADING THE FIELD ACCREDITATIONS AT A NATIONAL LEVEL

ASSOCIATION OF UNIVERSITY CARDIOLOGISTS

Susan Smyth, MD, President David Moliterno, MD Vincent Sorrell, MD Leo Horan, MD

AHA JOURNAL: ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY Alan Daugherty, PhD, Editor in Chief

JACC: CARDIOVASCULAR INTERVENTIONS

David Moliterno, MD, Editor in Chief Khaled Ziada, MD, Deputy Editor Adrian Messerli, MD, Associate Editor - Imaging

KENTUCKY CHAPTER OF THE AMERICAN COLLEGE OF CARDIOLOGY High Performing in: Khaled Ziada, MD, Governor U.S. NEWS BEST HOSPITALS Susan Smyth, MD, Immediate Past Governor Gretchen Wells, MD, PhD, Secretary/Treasurer Steve Leung, MD, Annual Scientific Meeting Committee Chair NO. 1 HOSPITAL IN KENTUCKY Tracy Macaulay, PharmD, Councilor Majd Makhoul, MD, Councilor Matthew Sousa, MD, FIT Liaison 36 | UK Gill Heart & Vascular Institute By the Numbers | 37

GILL HEART & VASCULAR INSTITUTE OVERALL FACULTY STUDENTS

Valve CABG AMI PERFORMANCE COMPOSITE 213 367 65 29 98% CLINICAL CLINICAL FELLOWS FELLOWS Peripheral of our patients met eligible opportunities of performance measure Vascular opportunities—the U.S. average for Intervention hospitals is 95.5%. 101 71 30 RESEARCH POSTDOCS MAZE DEFECT-FREE CARE 19 Transplant ECMO 28 74.6% 38 120 PHD of our patients received “perfect care” based VAD upon eligibility for each performance measure— STUDENTS 26 TEVAR and the U.S. average for hospitals is 61.4%. EVAR Watchman 129 58 Carotid Artery Stent TAVR 65 113

$44MIL 226 35 16 10 ~600 in Research Funding Publications Clinical Trials Affiliate Hospitals Outreach Locations Hours of Clinical and Community Education 38 | UK Gill Heart & Vascular Institute By the Numbers | 39

GILL HEART & VASCULAR INSTITUTE STRUCTURAL UK HealthCare US Hospitals It is our goal at Gill Heart & Vascular Institute to provide transparency to our interventional and catheterization quality. TAVR Cases We follow PCI standards dictated by the American College of Cardiology and CMS, and we report to the CathPCI registry to gauge our current quality and note areas of improvement. POST TAVR MOD-SEVERE AORTIC RISK ADJUSTED IN-HOSPITAL MORTALITY ODDS REGURGITATION RATIO - (R3Y) 4 1.25 OVERALL PCI RISK-ADJUSTED MORTALITY APPROPRIATENESS OF PCI 1 Lower is better PROCEDURES - 2019 3 1.17 1.02 1 0.97 0.99 0.99 Higher is better 0.75

Non-ACS Patients 2 3.5 100 0.5 3 80 1.2 1 1.2 UK HealthCare 0.25 2.5 2.7 60 0.8 0.9 60.76% 2 40 0 0 US Hospitals 45.22% 0 0 1.5 1.81 20 2017 2018 2019 2017 2018 2019

1 0 Percentage of patients with a major complication prior to disharge

MEDIAN TIME TO PRIMARY UK HealthCare PCI (D2BT) 42 HEART FAILURE Door to Balloon Time (Minutes) Heart disease is the leading cause of death in Kentucky. We record, review and report quality metrics to ensure that we CathPCI Registry Aggregate Data Lower is better 60 pinpoint potential areas of improvement and continue to provide the highest quality care to our sickest patients.

ONE YEAR GRAFT AND PATIENT SURVIVAL LVAD OUTCOMES Percent free from device malfunction and/or thrombosis 10 9 Months after UK 9.26 U.S. device implant HealthCare IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR (ICD) STEMI PERFORMANCE COMPOSITE 8 8.83 REGISTRY DATA 7 1 96.7% 99.5% 6 3 92.47% 95.4% 5 5.00 95.2% 96.3% 4 5.00 6 88.5% 90.9% 3 12 81.5% 82.7% of our patients that received ICD in 2018 fulfill class I, IIa or IIb of our STEMI patients met eligible 2 guideline indications—the U.S. average for hospitals is 89.7%. opportunities of performance 1 Percent free from infection measure opportunities—the U.S. 0 average is 92.6%. UK Graft Failures Patient Deaths v U.S. (90 Transplants) (89 Transplants) HealthCare 99.5% 1 81.1% 96.6% 3 72.2% 87.8% of our ICD patients received the appropriate Observed Expected medications on discharge—the U.S. average is 92.5%. 6 64.8% 79.0% Date from SRTR, (January ‘16 – June ‘18) 12 54.0% 62.8%

Intermacs Quality Assurance Quarterly Report (June ‘06 – March ‘19) 40 | UK Gill Heart & Vascular Institute Affiliate Network | 41

Systolic Blood Pressure CARDIAC At Entry Upon Completion CARDIAC CARE, ACROSS REHAB 144 138 THE COMMONWEALTH

Affiliate Network increases access to quality cardiovascular care across the state

6 Minute Walk Distance Kentuckians across the across Kentucky and in the sur- physician recruitment, supply and 84% Commonwealth deserve access rounding region. By allowing these equipment review and consultation, to the highest-level care for their patients to receive cardiovascular staff training and on-boarding, and UK HealthCare referred to cardiac rehab after a At Entry Upon Completion cardiovascular conditions. The Gill care close to home for as long as ongoing case quality review. qualifying event. Heart & Vascular Institute Affiliate possible, the Affiliate Network can 1240 1531 Network exists to help those reduce both stress and costs for “The University of Kentucky’s Kentuckians get that care, closer patients and their families. presence in our community has to home. By partnering with local been invaluable,” said Hillary community hospitals and medical To further enhance access to car- Strahan, BSN, Director of Cardiac centers, the Affiliate Network is diovascular care across the state, Services at Affiliate Network PHQ-9 Depression Survey growing and enhancing access to Gill Heart & Vascular Institute member Owensboro Health. 11 OF 12 state-of-the-art cardiovascular care continues to expand its footprint by “Owensboro Health has benefited across the region. embarking in unique collaborations from our affiliation in ways we At Entry Upon Completion patients counseled for tobacco cessation reported with Affiliate Network members. didn’t expect. Your team’s contin- cessation or reduction of tobacco use by half at Through the Affiliate Network For example, Gill Heart & Vascular ued contribution to our education, program completion. 5.8 4.6 platform, members gain access to Institute will soon provide full- growth, and improved patient a range of benefits and services, time, on-site cardiovascular care at outcomes make us a stronger including cardiovascular-specific Frankfort Regional Medical Center, service and we are appreciative and education and training, achieve- a member of the Affiliate Network. eager to continue working with UK ment and maintenance of subspe- Services will include outpatient HealthCare Gill Heart & Vascular cialty accreditations, access to Gill and inpatient general cardiology, Institute.” Heart & Vascular Institute faculty cardiac catheterization and and staff, networking and partner- angioplasty, outpatient electrophys- “The University of ing initiatives, comarketing and iology consultations, and patient Kentucky’s presence in cobranding opportunities, clinical education and training. Currently, our community has been cardiology coverage based on interventional cardiology faculty invaluable.” availability, and support for cardiac from Gill Heart & Vascular Institute - HILLARY STRAHAN, BSN program growth and development. can perform elective procedures in Frankfort Regional’s cardiac Each member hospital receives per- catheterization lab, and provide sonalized and customized attention 24/7 coverage for emergencies. from Gill Heart & Vascular Institute Affiliate Network staff to address Gill Heart & Vascular Institute will their needs across the CV spectrum, also provide expertise and support providing the right care in the for the development and construc- right place at the right time. This tion of the new permanent cardiac ensures that the full complement of catheterization laboratory at Clark heart care, from medical cardiology Regional Medical Center. The Gill to vascular and cardiothoracic Heart & Vascular Institute team surgery, is accessible to patients will assist with catheterization lab Affiliate Partners Outreach Clinics Fellows 42 | UK Gill Heart & Vascular Institute Education | 43

TRAINING THE NEXT GENERATION Cardiology Fellowship Program excels—even in a challenging year

The Cardiology Fellowship Program Virtual graduation for the The team continues to build the consists of fellows across the Cardiology Fellowship Program Cardiology Fellowship Alumni spectrum of cardiac sub-special- was held in June, with a com- network, with some former fellows ties: categorical cardiovascular mencement address provided by the providing feedback on training at disease, advanced cardiac imaging, President of the American College UK. These Fellow Ambassadors are interventional cardiology, electro- of Cardiology, Dr. Athena Poppas, a testament to the many hardwork- physiology, advanced heart failure, MD, FACC. The virtual nature of ing physicians, advanced practice and critical care cardiology. this year’s ceremony allowed family providers, nurses, and staff that members to join from across the collectively make UK a preeminent In 2019 - 2020, 26 fellows partic- globe, including a number from choice for fellows training in ipated in 50 total peer-reviewed Nigeria—proof of the pride these cardiovascular medicine. publications, 35 national presen- families have in the highly-accom- Staff that collectively make tations, and one national grand plished young men and women UK a great place to train in rounds. graduating from the program. Cardiovascular Medicine.

The Cardiology Fellowship Their impressive record of Photo caption pa volori tecumqu atatem quo Program has not been immune to accomplishments distin- temporrovit, nesciatem. Et ut dolo vellaudaes the impact of COVID-19. The team eumquam volest porehen debist, optatio guishes this group as a truly ratque perum facipsape pedis con nis delliatur rapidly created a safe working gifted class of cardiovascu- am, nulpa consequibus. environment, largely by switching lar trainees. to virtual educational sessions. The team’s ability to adjust to online Over the course of their three-year teaching and learning helped fellowship, the current graduating maintain a sense of normalcy and class published more than 100 well-being, while allowing edu- peer-review publications, presented cation to continue at a rapid pace, their work at 82 national events, as required by the team’s training and accumulated three university goals and expectations. Many grand rounds invitations. Their takeaways from this year’s remote impressive record of accomplish- instruction will continue to be used ments distinguishes this group as a by future fellows and faculty, even truly gifted class of cardiovascular post-pandemic. trainees. As a further testament to their academic investments, every 26 fellows participated in 50 single graduating fellow from this total peer-reviewed publi- year’s Categorical Cardiovascular cations, 35 national presen- Disease Fellowship Training tations, and one national Program extended their training to grand rounds. develop their sub-specialty exper- tise even further. 44 | Research Leadership | 45

MOVING CARDIAC LEADERSHIP CARE FORWARD

Innovative Clinical Research division means more options for more patients Gill Heart & Vascular Institute Office of the Executive

Led by Khaled Ziada, MD, and approaches, including renal Institutes of Health, places the Vice President for Health Affairs: Clinical Research Director Jennifer denervation, left atrial pressure university in an elite group of 60 SUSAN S. SMYTH, MD, PhD MARK NEWMAN, MD Isaacs, MS, MS, CCRP, the Clinical monitoring for heart failure, resorb- biomedical research institutions Director Executive VP for Health Affairs Research division of the Gill Heart able coronary stents and stem cell poised to solve the toughest Chief, Cardiovascular Medicine & Vascular Institute is helping push regenerative medicine. Historically, challenges in medicine and surgery Jeff Gill Professor of Cardiology MARK D. BIRDWHISTELL, VP the field forward by supporting the division has been a top enroller using innovative approaches. VP for Health System Administration & Chief of Staff Phase 1 through 4 drug and device in multicenter trials investigating ERIC D. ENDEAN, MD Deputy Director clinical trials. These trials cover novel devices for PFO closure, left Gill Heart & Vascular CRAIG C. COLLINS. VP Chief, Vascular Surgery a multitude of areas, including atrial pressure monitoring (to treat Chief Financial Officer Institute’s commitment Gordon L. Hyde Endowed structural heart disease, coronary heart failure) and ASD closure as to clinical trial research Professor of Vascular Surgery ROBERT S. DIPAOLA, MD artery disease, heart failure and well as novel drugs for treatment of increases the accessibility of VP & Dean, UK College of Medicine electrophysiology. ACS and the prevention of second- MICHAEL SEKELA, MD ary coronary events. state-of-the-art treatments to patients across Kentucky. Deputy Director JAY GRIDER, DO, PHD The strength of the team’s Chief, Cardiothoracic Surgery Chief Physician Executive clinical research efforts is Gill Heart & Vascular Institute’s Professor of Surgery commitment to clinical trial unmatched. CONNIE JENNINGS, MD research increases the accessibility Medical Director, CareBlue The strength of the team’s clinical of state-of-the-art treatments to research efforts, particularly re- patients across Kentucky—access CECILIA PAGE, DNP garding innovative catheter-based that would otherwise not exist Chief Information Officer approaches to heart and vascular in this region of the country. The disease, is unmatched. The Clinical University of Kentucky’s Center for JOHN A. PERRY Research division conducts lead- Clinical and Translational Science Associate VP for Philanthropy ing-edge cardiovascular treatment (CCTS), awarded by the National BRETT SHORT Chief Compliance Officer

COLLEEN SWARTZ, DNP VP for Hospital Operations

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SUSAN S. SMYTH, MD, PhD ERIC D. ENDEAN, MD MICHAEL SEKELA, MD 46 | UK Gill Heart & Vascular Institute Faculty | 47

FACULTY

CLINICAL FACULTY HEART FAILURES/MCS and TRANSPLANTATION VASCULAR SURGERY Chien-Suu Kuo, MD Paul Anaya, MD, PhD Joseph L. Bobadilla, MD, FACS Sangderk Lee, PhD ADULT CONGENITAL HEART DISEASE Emma J. Birks, MD Michael C. Bounds, MD Terry A. Lennie, PhD, RN, FAHA, FAAN Steve W. Leung, MD Andrew R. Leventhal, MD David C. Booth, MD Eric D. Endean, MD, FACS Andrew R. Leventhal, MD, PhD Douglas J. Schneider, MD Andrew R. Kolodziej, MD David J. Minion, MD, FACS Zhenyu Li, MD, PhD Mark Vranicar, MD Suresh Keshavamurthy, MBBS Nathan T. Orr, MD Rajasekhar S. R. Malyala, MD Samuel C. Tyagi, MD Robert A. Lodder, PhD Analia Loria, PhD CARDIOLOGY Michael E. Sekela, MD, FACS Eleftherios S. Xenos, MD, PhD, RVT, FACS Neetti Reddy, MD Hong S. Lu, MD, PhD Yuri Boyechko, MD Rick R. McClure, MD Guarang Vaidya VASCULAR SURGERY Craig A. Chasen, MD Adrian Messerli, MD Joseph L. Bobadilla, MD, FACS Luis Francisco Hidalgo Ponce, MD David J. Moliterno, MD INTERVENTIONAL Michael C. Bounds, MD Chien-Suu Kuo, MD Andrew J. Morris, PhD Rick R. McClure, MD Ahmed Abdel-Latif, MD, MSc, PhD Eric D. Endean, MD, FACS Debra Moser, PhD, RN, FAHA, FAAN Michael E. McKinney, MD David C. Booth, MD David J. Minion, MD, FACS Mohammed Mottaleb, PhD Gbolahan Ogunbayo, MD John C. Gurley, MD Nathan T. Orr, MD Gia Mudd-Martin, PhD, MPH, RN Charles R. Salters, MD Andrew R. Leventhal, MD Samuel C. Tyagi, MD Timothy Wm. Mullett, MD Susan S. Smyth, MD, PhD, FACC Adrian W. Messerli, MD Eleftherios S. Xenos, MD, PhD, RVT, FACS Mariana Nikolova-Karakashian, PhD Joseph E. Thomas, MD Naoki Misumida, MD M. Elizabeth Oates, MD Gretchen L. Wells, MD, PhD David J. Moliterno, MD RESEARCH FACULTY Frederick O. Onono, PhD Khaled M. Ziada, MD, FACC, FSCAI Thomas Whayne Jr., MD, PhD Ahmed Abdel-Latif, MD, PhD Jeffrey L. Osborn, PhD Paul Anaya, MD, PhD Sabire Oscan, PhD PHARMACY CARDIAC SURGERY Douglas A. Andres, PhD Kevin J. Pearson, PhD Suresh Keshavamurthy, MBBS Ayesha Ather, PharmD, BCPS Donna Arnett, PhD, MSPH Julie Pendergast, PhD Tessa E. London, MD Craig Beavers, PharmD, BCPS, BCCP, FAHA Cherry Ballard-Croft, PhD Todd Porter, PhD Rajasekhar S. R. Malyala, MD Terri Cook, PharmD, BCPS Maher Baz, MD Sibu P. Saha, MD, MBA Michael Sekela, MD Jackoline M. Costantino, PharmD, BCCP David C. Booth, MD Jonathan Satin, PhD Hassan Reda, MD George Davis, PharmD, BCPS Kenneth S. Campbell, PhD Nancy E. Schoenberg, PhD Jessie Dunne, PharmD, BCPS Lisa A. Cassis, PhD Mary B. Sheppard, MD CARDIOVASCULAR IMAGING Margaret Felix, PharmD Craig A. Chasen, MD Mikel D. Smith, MD Susan S. Smyth, MD, PhD Michael A. Brooks, MD Heather H. Hesselson, PharmD, BCPS Misook Lee Chung, PhD, RN, FAHA, FAAN Vincent L. Sorrell, MD Vedant A. Gupta, MD, FACC Mark Huffyer, PharmD, MCACP, BCGP Cherry Ballard-Croft, Ph.D. Venkateswaran Subramanian, PhD Stephen B. Hobbs, MD Kayla N. Kreft, PharmD, KCACP Alan Daugherty, PhD, DSc Lisa Tannock, MD John R. Kotter, MD Will Kuan, PharmD, BCCP Frederick C. de Beer, MD Ryan Temel, PhD Steve W. Leung, MD Tracy E. Macaulay, PharmD, BCCP, AACC, BCPS Brian P. Delisle, PhD Komal Pandya, PharmD, BCCCP, BCPS Eric D. Endean, MD, FACS Sean E. Thatcher, PhD M. Elizabeth Oates, MD, FAAWR, FACR Mark Vranicar, MD Mikel D. Smith, MD, FACC Ashley Schenk, PharmD, BCCP Victor M. Ferraris, MD, PhD Adam Sieg, PharmD, BCPS Ming C. Gong, PhD, MD Shuxia Wang, MD, PhD Vincent L. Sorrell, MD, FACC, FACP Christopher M. Waters, PhD Marianna Zagurovskaya, MD Brittany Smith, PharmD Scott M. Gordon, PhD Gregory Graf, PhD Nancy R. Webb, PhD PULMONARY HYPERTENSION Zhenheng Guo, PhD Thomas F. Whayne, Jr., MD, PhD ELECTROPHYSIOLOGY Sidney W. Whiteheart, PhD David C. Booth, MD John C. Gurley, MD Kristin E. Ellison, MD Jeremy P. Wood, PhD Andrew R. Kolodziej, MD Robert W. Hadley, PhD Aaron B. Hesselson, MD, FACC, FHRS Bernhard Henning, PhD Changcheng Zhou, PhD Stephen Hobbs, MD, FSCCT Khaled M. Ziada, MD Brian A. Jackson, PhD Joseph B. Zwischenberger, MD Victoria L. King, PhD 48 | UK Gill Heart & Vascular Institute Clinical Trials | 49

undergoing MCS therapy with HeartMate 3™. PI: Aaron Hesselson, MD

CLINICAL TRIALS PI: Maya Guglin, MD, PhD Clinical study intended to confirm the safety and efficacy of the Sentus QP leads to support regulatory approval, as • Continued access protocol for the HeartMate 3 LVAD. well as to assess if pacing thresholds of the lead are in an • Subjects with advanced heart failure New York Heart acceptable range after implantation. Association (NYHA) Class III patients with dyspnea upon ALLOMAP REGISTRY (CARE DX, INC.) Objective: Restoring the function of damaged heart mild physical activity, or NYHA Class IV who are refrac- SPYRAL HTN OFF MEDS (MEDTRONIC) PI: Navin Rajagopalan, MD muscle with experimental study product cells. tory to advanced heart failure management. Global clinical study of renal denervation with the Symplicity Spyral multi-electrode renal denervation Objective: Analyze medical records and observe clinical FAME 3 (STANFORD UNIVERSITY) OPUS REGISTRY (ACTELION) system in patients with uncontrolled hypertension in the outcomes in heart transplant recipients who receive Fractional flow reserve versus angiography for multives- Opsumit users registry absence of antihypertensive medications. regular AlloMap testing as part of allograft rejection sel evaluation (FAME) 3 trial surveillance. PI: David Booth, MD PI: Khaled Ziada, MD PI: Ahmed Abdel-Latif, MD, PhD (VA) AMULET (ST. JUDE MEDICAL) This study is a prospective observational drug registry TAFI/ DS1040B (DAIICHI SANKYO, INC.) Comparison of Amplatzer™ Amulet™ LAA occluder A comparison of fractional flow reserve-guided percuta- developed to further characterize the safety profile A phase 1b, randomized, double-blind, placebo-controlled, safety and efficacy in patients with non-valvular atrial neous coronary intervention and coronary artery bypass (including primarily potential serious hepatic risks) multi-center, single ascending dose study to assess the fibrillation to Boston Scientific LAA occluder. graft surgery in patients with multivessel coronary and to describe clinical characteristics and outcomes of safety, efficacy, pharmacokinetics, and pharmacodynam- artery disease. patients newly treated with Opsumit in the post-market- ics of DS-1040B when added to standard of care anti- Patients over the age of 18 with documented paroxysmal, ing setting. coagulation therapy in subjects with acute submassive persistent, or permanent non-valvular atrial fibrillation FIX-HF-5CA (IMPULSE DYNAMICS, INC.) pulmonary embolism. who are also deemed suitable for LAA closure. Continued access protocol for the evaluation of the PFO PAS (ABBOTT) OPTIMIZER Smart System in subjects with mod- AMPLATZER PFO Occluder post approval study PI: Susan Smyth, MD, PhD BeAT-HF (CVRx) erate-to-severe heart failure with ejection fraction BAROSTIM NEO – Baroreflex activation therapy for between 25% and 45%. PI: John Gurley, MD TDE-HF-301/ SOUTHPAW (UNITED THERAPEUTICS) heart failure A multi-center, randomized, double-blind, placebo-con- PI: Aaron Hesselson, MD Clinical study intended to demonstrate the safety and trolled study to evaluate the safety and efficacy of oral PI: Aaron Hesselson, MD effectiveness of the AMPLATZER PFO Occluder, in a post treprostinil in subjects with pulmonary hypertension Objective: Allow ongoing access to treatment of patients approval setting, in patients with a PFO who have had a (PH) in heart failure with preserved ejection fraction Objective: to determine the safety and efficacy of the suffering from moderate to severe heart failure at cryptogenic stroke. (HfpEF). Barostim Neo system in heart failure patients. The selected investigational sites until the PMA order has device is designed to stimulate baroreceptors in patients been issued by the FDA for the OPTIMIZER System. The The PRECISE Protocol: PI: David Booth, MD with NYHA Class II or III heart failure over the age of OPTIMIZER Smart System stimulates the heart muscle Prospective randomized trial of the optimal evaluation of 21. with CCM treatment. cardiac symptoms and revascularization (PRECISE) Objective: To assess the effect of oral treprostinil compared with placebo on change in exercise capacity as COMPASSION S3 (EDWARDS LIFESCIENCES) INTELLECT 2-HF (ABBOTT) PI: Vincent L. Sorrell, MD measured by change in 6MWD from baseline to Week 24 Congenital multicenter trial of pulmonic valve dysfunc- Investigation to optimize hemodynamic management in subjects with PH associated with HFpEF. tion studying the SAPIEN 3 interventional THV of HeartMate II Left Ventricular Assist Device patients Objective: Assess clinical outcomes, decision-making using the CardioMEMS pulmonary artery pressure regarding noninvasive testing and invasive angiography, TDE-HF-302/ SOUTHPAW (UNITED THERAPEUTICS) PI: Andrew Leventhal, MD, PhD sensor in advanced heart failure. and costs using a precision evaluation strategy as An open-label extension study of oral treprostinil in compared to a usual care strategy in participants with subjects with pulmonary hypertension (PH) associated Objective: To determine safety and efficacy of the PI: Maya Guglin, MD, PhD stable symptoms suggestive of significant coronary with heart failure with preserved ejection fraction Edwards Sapien 3 Transcatheter Heart Valve System in artery disease. The precision evaluation strategy will be (HfpEF)—a long-term follow-up to Study TDE-HF-301. patients with dysfunctional right ventricular outflow Objective: Determine if management strategies applied based on a pre-test risk assessment and will incorporate tract with clinical indication for intervention. to patients with heart failure who have a HeartMate cCTA with selective FFRCT and guideline-recommended PI: David Booth, MD LVAD and also a CardioMEMS HF Monitoring System care with symptom and risk factor management and no DREAM HF (MESOBLAST) will improve how they feel and what they can do. The immediately planned testing. Objective: Evaluate the long-term safety of oral trepros- Efficacy and safety study of allogeneic stem cells in purpose of this small study is to better understand how tinil in subjects with PH associated with HFpEF for patients with chronic heart failure due to left ventric- these two devices can be used together to help heart QP ExCELs (BIOTRONIK) subjects who completed Study TDE-HF-301. ular systolic dysfunction of either ischemic or nonisch- failure patients. Sentus QP - Extended CRT evaluation with quadripolar emic etiology left ventricular leads MOMENTUM 3 CAP (ST. JUDE MEDICAL) PI: Ahmed Abdel-Latif, MD, PhD Multi-center study of MagLev technology in patients 50 | UK Gill Heart & Vascular Institute Publications | 51

PUBLICATIONS

CLINICAL TRIALS

TDE-HF-401/ ADAPT REGISTRY (UNITED Women’s IschemiA TRial to Reduce Events In Non- Abdel-Latif A, Misumida N. Ischemic Stroke After L, Komolafe M, Faniyan MM, Arulogun O, Obiako R, THERAPEUTICS) ObstRuctive CAD (WARRIOR) Percutaneous Coronary Intervention: Rare, But Owolabi M. Echocardiographic Abnormalities and A patient registry of the real-world use of Orenitram Devastating. JACC Cardiovasc Interv. 2019 Aug Determinants of 1-Month Outcome of Stroke Among West PI: Gretchen Wells, MD 12;12(15):1507-1509. doi: 10.1016/j.jcin.2019.05.013. Africans in the SIREN StudyJ Am Heart Assoc. 2019 Jun PI: David Booth, MD 4;8(11):e010814. doi: 10.1161/JAHA.118.010814.. Objective: Determine whether intensive medication Abo-Aly M, Lolay G, Adams C, Ahmed AE, Abdel-Latif Objective: Patient registry that will follow patients who treatment to modify risk factors and vascular function A, Ziada KM. Comparison of intracoronary versus Ahern BM, Levitan BM, Veeranki S, Shah M, Ali N, are newly initiated on Orenitram for the treatment of in women patients with coronary arteries showing no intravenous adenosine-induced maximal hyperemia Sebastian A, Su W, Gong MC, Li J, Stelzer JE, Andres DA, PAH to assess real-world use and tolerability. flow limit obstruction but with cardiac symptoms (i.e., for fractional flow reserve measurement: A systematic Satin J. Myocardial-restricted ablation of the GTPase chest pain, shortness of breath) will reduce the patient’s review and meta-analysis. Catheter Cardiovasc Interv. RAD results in a pro-adaptive heart response in mice. J XIENCE Short DAPT (ABBOTT) likelihood of dying, having a heart attack, stroke/TIA 2019 May 9. doi: 10.1002/ccd.28317. Biol Chem. 2019 Jul 12;294(28):10913-10927. doi: 10.1074/ or being hospitalized for cardiac reasons. The results jbc.RA119.008782. PI: Khaled Ziada, MD will provide evidence data necessary to inform future Abo-Aly M, Misumida N, Backer N, ElKholey K, Kim SM, guidelines regarding how best to treat this growing Ogunbayo GO, Abdel-Latif A, Ziada KM. Percutaneous Ahern BM, Satin J. The L-type calcium channel current Objective: Evaluate safety of 3-month dual antiplatelet population of patients, and ultimately improve the Coronary Intervention With Drug-Eluting Stent Versus modulation mechanism: the plot thickens and fogs. The therapy (DAPT) in subjects at high risk of bleeding patient’s cardiac health and quality of life and reduce Optimal Medical Therapy for Chronic Total Occlusion: undergoing PCI with XIENCE stent. healthcare costs. Journal of clinical investigation. 2019;129:496-498. Systematic Review and Meta-Analysis. Angiology. 2019 An international pulmonary embolism registry using Nov;70(10):908-915. doi: 10.1177/0003319719858823. Akpalu A, Gebregziabher M, Ovbiagele B, Sarfo F, EKOS (KNOCOUT PE) Iheonye H, Akinyemi R, Akpa O, Tiwari HK, Arnett D, Abraham CM, Kelly S, Wantland D, Chung ML, Mudd- Wahab K, Lackland D, Abiodun A, Ogbole G, Jenkins PI: Adrian Messerli, MD Martin G, Biddle MJ, Moser DK. Factors Influencing C, Arulogun O, Akpalu J, Obiako R, Olowoyo P, Fawale Cardiovascular Risk Factors and Health Perception M, Komolafe M, Osaigbovo G, Obiabo Y, Chukwuonye I, Objective: This registry is designed to understand Among Kentuckians Living in Appalachia. J Cardiovasc Owolabi L, Adebayo P, Sunmonu T, Owolabi M. DiStroke. acoustic pulse thrombolysis (APT) treatment regimens Nurs. 2019 Jul 23. doi: 10.1097/JCN.0000000000000594. Differential Impact of Risk Factors on Stroke Occurrence used as standard of care globally for pulmonary Among Men Versus Women in West Africa. 2019 embolism. The registry will include individuals who Abu-Hijleh M, Styrvoky K, Anand V, Woll F, Yarmus Apr;50(4):820-827. doi: 10.1161/STROKEAHA.118.022786. have already received the APT treatment and those that L, Machuzak MS, Nader DA, Mullett TW, Hogarth DK, will undergo APT treatment. Toth JW, Acash G, Casal RF, Hazelrigg S, Wood DE. AlGhuraibawi W, Stromp T, Holtkamp R, Lam B, Intrabronchial Valves for Air Leaks After Lobectomy, Rehwald W, Leung SW, Vandsburger M. CEST MRI Segmentectomy, and Lung Volume Reduction reveals a correlation between visceral fat mass and Surgery. Lung. 2019 Oct;197(5):627-633. doi: 10.1007/ reduced myocardial creatine in obese individuals s00408-019-00268-7. despite preserved ventricular structure and function. NMR Biomed. 2019 Jul;32(7):e4104. doi: 10.1002/ Adamiak M, Bujko K, Cymer M, Plonka M, Glaser T, Kucia nbm.4104. Alnabelsi T, Shafii AE, Gurley JC, Dulnuan M, Ratajczak J, Ulrich H, Abdel-Latif A, Ratajczak MZ. K, Harris DD 2nd, Guglin M. Left Ventricular Assist Correction: Novel evidence that extracellular nucleotides Device Outflow Graft Obstruction: A Complication and purinergic signaling induce innate immunity-me- Specific to Polytetrafluoroethylene Covering. A Word of diated mobilization of hematopoietic stem/progenitor Caution! ASAIO J. 2019 Aug;65(6):e58-e62. doi: 10.1097/ cells. Leukemia. 2019. MAT.000000000000092.

Adeoye AM, Ovbiagele B, Akinyemi JO, Ogah OS, Alqahtani F, Ziada KM, Badhwar V, Sandhu G, Rihal Akinyemi R, Gebregziabher M, Wahab K, Fakunle AG, CS, Alkhouli M. Incidence, Predictors, and Outcomes Akintunde A, Adebayo O, Aje A, Tiwari HK, Arnett D, of In-Hospital Percutaneous Coronary Intervention Agyekum F, Appiah LT, Amusa G, Olunuga TO, Onoja Following Coronary Artery Bypass Grafting. Journal of A, Sarfo FS, Akpalu A, Jenkins C, Lackland D, Owolabi the American College of Cardiology. 2019;73:415-423. 52 | UK Gill Heart & Vascular Institute Publications | 53

PUBLICATIONS

AlSiraj Y, Chen X, Thatcher SE, Temel RE, Cai L, Biddle MJ, Moser DK, Pelter MM, Robinson S, Dracup K. Chen J, Wang S, Zhang Z, Richards CI, Xu R. Heat shock Obesity-Induced Hypertension. J Am Heart Assoc. 2019 Blalock E, Katz W, Ali HM, Petriello M, Deng P, Morris Predictors of Adherence to Self-Care in Rural Patients protein 47 (HSP47) binds to discoidin domain-containing Dec 3;8(23):e012309. doi: 10.1161/JAHA.119.012309. AJ, Wang X, Lusis AJ, Arnold AP, Reue K, Thompson With Heart Failure. J Rural Health. 2019 Dec 15. doi: receptor 2 (DDR2) and regulates its protein stability. Daugherty A. Recipients of the 2019 Early Career K, Tso P, Cassis LA. XX sex chromosome complement 10.1111/jrh.12405. J Biol Chem. 2019 Sep 30. pii: jbc.RA119.009312. doi: Investigator Awards. Arterioscler Thromb Vasc Biol. promotes atherosclerosis in mice. Nat Commun. 2019 Jun 10.1074/jbc.RA119.009312. 2019 May;39(5):835. doi: 10.1161/ATVBAHA.119.312479. 14;10(1):2631. doi: 10.1038/s41467-019-10462-z. Brandon JA, Kraemer M, Vandra J, Halder S, Ubele M, Morris AJ, Smyth SS. Adipose-derived autotaxin Chen JZ, Sawada H, Moorleghen JJ, Weiland M, Davis FM, Daugherty A, Lu HS. Updates of Recent Arnett DK, Claas SA. Tracing and Assessing the regulates inflammation and steatosis associated with Daugherty A, Sheppard MB. Aortic Strain Correlates Aortic Aneurysm Research. Arterioscler Thromb Vasc Evolution of Clinical Guidelines. J Am Heart Assoc. 2019 diet-induced obesity. PloS one. 2019;14:e0208099. with Elastin Fragmentation in Fibrillin-1 Hypomorphic Biol. 2019;39:e83-e90. Oct;8(19):e014060. doi: 10.1161/JAHA.119.014060. Mice. Circ Rep. 2019 May 10;1(5):199-205. doi: 10.1253/ Bugajski A, Frazier SK, Cousin L, Rechenberg K, Brown J, circrep.CR-18-0012. de Las Fuentes L, Sung YJ, Sitlani CM, Avery CL, Bartz Ather A, Beavers CJ. Use of Alternative Antiplatelet Lengerich AJ, Moser DK, Lennie TA. Effects of a Digital TM, Keyser C, Evans DS, Li X, Musani SK, Ruiter R, Agents for Clopidogrel Hypersensitivity. Curr Vasc Self-care Intervention in Adults with COPD: A Pilot Choi M, Schuster AM, Schoenberg NE. Solutions Smith AV, Sun F, Trompet S, Xu H, Arnett DK, et al. Pharmacol. 2019;17:127-132. Study. West J Nurs Res. 2019 Dec 19:193945919892282. to the Challenge of Meeting Rural Transportation Genome-wide meta-analysis of variant-by-diuretic doi: 10.1177/0193945919892282. Needs: Middle-Aged and Older Adults’ Perspectives. J interactions as modulators of lipid traits in persons of Ather A, Laliberte B, Reed BN, Schenk A, Watson Gerontol Soc Work. 2019 May-Jun;62(4):415-431. doi: European and African ancestry. Pharmacogenomics J. K, Devabhakthuni S, See VY. Antithromboembolic Bugajski A, Frazier SK, Moser DK, Chung M, Lennie 10.1080/01634372.2019.1575133. 2019 Dec 6. doi: 10.1038/s41397-019-0132-y. Strategies for Patients with Atrial Fibrillation TA. Airflow limitation more than doubles the risk for Undergoing Percutaneous Coronary Intervention. Am J hospitalization/mortality in patients with heart failure. Chopra AM, Díez-Villanueva P, Córdoba-Soriano JG, Lee Delisle BP, Yu Y, Puvvula P, Hall AR, Huff C, Moon AM. Cardiovasc Drugs. 2018;18:441-455. Eur J Cardiovasc Nurs. 2019;18:245-252. JKT, Al-Ahmad M, Ferraris VA, Mehta M, Kowalski ML. Tbx3-Mediated Regulation of Cardiac Conduction System Meta-Analysis of Acetylsalicylic Acid Desensitization Development and Function: Potential Contributions Baber U, Leisman DE, Cohen DJ, Gibson CM, Henry TD, Butler CR, Boychuk JA, Pomerleau F, Alcala R, Huettl in Patients With Acute Coronary Syndrome. Am of Alternative RNA Processing. Pediatr Cardiol. 2019 Dangas G, Moliterno D, Kini A, Krucoff M, Colombo A, P, Ai Y, Jakobsson J, Whiteheart SW, Gerhardt GA, J Cardiol. 2019 Jul 1;124(1):14-19. doi: 10.1016/j. Oct;40(7):1388-1400. doi: 10.1007/s00246-019-02166-4. Chieffo A, Sartori S, Witzenbichler B, Steg PG, Pocock SJ Smith BN, Slevin JT. Modulation of epileptogenesis: A amjcard.2019.03.047. and Mehran R. Tailoring Antiplatelet Therapy Intensity paradigm for the integration of enzyme-based microelec- Dellafiore F, Chung ML, Alvaro R, Durante A, to Ischemic and Bleeding Risk. Circ Cardiovasc Qual trode arrays and optogenetics. Epilepsy Res. 2019 Nov Chopra AM, Ferraris VA. Stopping Versus Continuing Colaceci S, Vellone E, Pucciarelli G. The Association Outcomes. 2019;12:e004945. 26;159:106244. doi: 10.1016/j.eplepsyres.2019.106244. Aspirin Before Coronary Artery Surgery for Desensitized Between Mutuality, Anxiety, and Depression in Heart Cardiac Patients. Ann Thorac Surg. 2019 May;107(5):1587. Failure Patient-Caregiver Dyads: An Actor-Partner Banerjee M, Huang Y, Ouseph MM, Joshi S, Pokrovskaya Campbell KS, Beard DA, Qu Z. The Heart by Numbers. doi: 10.1016/j.athoracsur.2018.10.037. Interdependence Model Analysis. J Cardiovasc I, Storrie B, Zhang J, Whiteheart SW, Wang QJ. Biophys J. 2019 Dec 17;117(12):E1-E3. doi: 10.1016/j. Nurs. 2019 Nov/Dec;34(6):465-473. doi: 10.1097/ Autophagy in Platelets. Methods Mol Biol. 2019;1880:511- bpj.2019.11.010. Chow KM, Whiteheart SW, Smiley JR, Sharma S, Boaz JCN.0000000000000599. 528. doi: 10.1007/978-1-4939-8873-0_32. K, Coleman MJ, Maynard A, Hersh LB, Vander Kooi CW. Campbell KS, Yengo CM, Lee LC, Kotter J, Sorrell VL, Immunization of Alpacas (Lama pacos) with Protein Deng P, Barney J, Petriello MC, Morris AJ, Wahlang B, Beavers CJ, Naqvi IA. Clopidogrel StatPearls Treasure Guglin M, Wenk JF. Closing the therapeutic loop. Arch Antigens and Production of Antigen-specific Single Hennig B. Hepatic metabolomics reveals that liver injury Island (FL): StatPearls Publishing StatPearls Publishing Biochem Biophys. 2019;663:129-131. Domain Antibodies. J Vis Exp. 2019 Jan 26;(143). doi: increases PCB 126-induced oxidative stress and meta- LLC.; 2019. 10.3791/58471. bolic dysfunction. Chemosphere. 2019;217:140-149. Cannon RM, Jones CM, Davis EG, Franklin GA, Gupta M, Becker MD, Butler PF, Siam M, Gress DA, Ghesani Shah MB. Patterns of geographic variability in mortality Coffey AR, Kanke M, Smallwood TL, Albright J, Pitman Deng P, Hoffman JB, Petriello MC, Wang CY, Li XS, M, Harkness BA, Yoo DC, Oates ME. U.S. PET/ and eligible deaths between organ procurement orga- W, Gharaibeh RZ, Hua K, Gertz E, Biddinger SB, Kraemer MP, Morris AJ, Hennig B. Dietary inulin CT and Gamma Camera Diagnostic Reference nizations. Am J Transplant. 2019 Apr 12. doi: 10.1111/ Temel RE, Pomp D, Sethupathy P, Bennett BJ. microR- decreases circulating ceramides by suppressing neutral Levels and Achievable Administered Activities for ajt.15390. NA-146a-5p association with the cardiometabolic disease sphingomyelinase expression and activity in mice. J Noncardiac Nuclear Medicine Studies. Radiology. 2019 risk factor TMAO. Physiol Genomics. 2019;51:59-71. Lipid Res. 2019 Oct 11. pii: jlr.RA119000346. doi: 10.1194/ Oct;293(1):203-211. doi: 10.1148/radiol.2019190623. Chen S, Henderson A, Petriello MC, Romano KA, Gearing jlr.RA119000346. M, Miao J, Schell M, Sandoval-Espinola WJ, Tao J, Coons JC, Pogue K, Kolodziej AR, Hirsch GA, Bender EM, Rizzo MG, Meyerson SL, Zwischenberger JB. Sha B, Graham M, Crooke R, Kleinridders A, Balskus George MP. Pulmonary Arterial Hypertension: a Diaz-Ruiz A, Di Francesco A, Carboneau BA, Levan SR, Pearson KJ, Price NL, Ward TM, Bernier M, de Cabo R, Surgeon as Programmer: Overcoming Obstacles to the EP, Rey FE, Morris AJ, Biddinger SB. Trimethylamine Pharmacotherapeutic Update. Curr Cardiol Rep. 2019 Mercken EM. Benefits of Caloric Restriction in Longevity Use of Modern Internet Technology for Cardiothoracic N-Oxide Binds and Activates PERK to Promote Metabolic Nov 22;21(11):141. doi: 10.1007/s11886-019-1235-4. and Chemical-Induced Tumorigenesis Are Transmitted Surgery. Ann Thorac Surg. 2019 Nov;108(5):1551-1554. Dysfunction. Cell Metab. 2019 Dec 3;30(6):1141-1151.e5. Independent of NQO1. The journals of gerontology doi: 10.1016/j.athoracsur.2019.04.084. doi: 10.1016/j.cmet.2019.08.021. Dalmasso C, Leachman JR, Ensor CM, Yiannikouris Series A, Biological sciences and medical sciences. FB, Giani JF, Cassis LA, Loria AS. Female Mice Exposed 2019;74:155-162. to Postnatal Neglect Display Angiotensin II-Dependent 54 | UK Gill Heart & Vascular Institute Publications | 55

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Do AN, Zhao W, Baldridge AS, Raffield LM, Wiggins KL, of migraine. Acta Cardiol. 2019 Apr;74(2):124-129. doi: Events After Percutaneous Coronary Intervention. Circ Filice RW, Stein A, Wu CC, Arteaga VA, Borstelmann Shah SJ, Aslibekyan S, Tiwari HK, Limdi N, Zhi D, Sitlani 10.1080/00015385.2018.1475027. Cardiovasc Interv. 2019 Apr;12(4):e007133. doi: 10.1161/ S, Gaddikeri R, Galperin-Aizenberg M, Gill RR, Godoy CM, Taylor KD, Psaty BM, Sotoodehnia N, Brody JA, CIRCINTERVENTIONS.118.007133. MC, Hobbs SB, Jeudy J, Lakhani PC, Laroia A, Nayak Rasmussen-Torvik LJ, Lloyd-Jones D, Lange LA, Wilson Elbadawi A, Elgendy IY, Mahmoud AH, Ogunbayo GO, SM, Parekh MR, Prasanna P, Shah P, Vummidi D, JG, Smith JA, Kardia SLR, Mosley TH, Vasan RS, Arnett Saad M, Megaly M, Alotaki E, Mentias A, Barakat AF, Falls C, Kolodziej AR. Surgical Approaches in Yaddanapudi K, Shih G. Crowdsourcing pneumothorax DK, Irvin MR. Genome-wide meta-analysis of SNP and London B. Outcomes of Surgical Ablation in Patients Heart Failure. Crit Care Nurs Clin North Am. 2019 annotations using machine learning annotations on the antihypertensive medication interactions on left ven- With Atrial Fibrillation Undergoing Cardiac Surgeries. Sep;31(3):267-283. doi: 10.1016/j.cnc.2019.04.003. NIH chest X-ray dataset. J Digit Imaging. 2019 Nov 25. tricular traits in African Americans. Mol Genet Genomic Ann Thorac Surg. 2019 May;107(5):1395-1400. doi: doi: 10.1007/s10278-019-00299-9. Med. 2019 Aug 13:e788. doi: 10.1002/mgg3.788. 10.1016/j.athoracsur.2018.10.040. Fan S, Kind T, Cajka T, Hazen SL, Tang WHW, Kaddurah- Daouk R, Irvin MR, Arnett DK, Barupal DK and Fiehn Firestone RL, Parker PL, Pandya KA, Wilson MD, Duby Dolmatch BL, Gurley JC, Baskin KM, Nikolic B, Lawson Elbadawi A, Elgendy IY, Naqvi SY, Mohamed AH, O. Systematic Error Removal Using Random Forest for JJ. Moderate-Intensity Insulin Therapy Is Associated JH, Shenoy S, Saad TF, Davidson I, Baerlocher MO, Ogunbayo GO, Omer MA, Mentias A, Saad M, Abbott Normalizing Large-Scale Untargeted Lipidomics Data. With Reduced Length of Stay in Critically Ill Patients Cohen EI, Dariushnia SR, Faintuch S, d’Othee BJ, JD, Jneid H, Bhatt DL. Temporal Trends and Outcomes Anal Chem. 2019;91:3590-3596. With Diabetic Ketoacidosis and Hyperosmolar Kinney TB, Midia M, Clifton J. Society of Interventional of Hospitalizations With Prinzmetal Angina: Hyperglycemic State. Crit Care Med. 2019 May;47(5):700- Radiology Reporting Standards for Thoracic Central Perspectives From a National Database. Am J Med. Fernandez JD, Kendjorsky K, Narla A, Villasante-Tezanos 705. doi: 10.1097/CCM.0000000000003709. Vein Obstruction: Endorsed by the American Society 2019 Apr 29. pii: S0002-9343(19)30342-0. doi: 10.1016/j. AG, Tannock LR. Assessment of Gender-Affirming of Diagnostic and Interventional Nephrology (ASDIN), amjmed.2019.04.005. Hormone Therapy Requirements. LGBT Health. 2019 Gatineau E, Cohn DM, Poglitsch M, Loria AS, Gong M, British Society of Interventional Radiology (BSIR), Apr;6(3):101-106. doi: 10.1089/lgbt.2018.0116. Yiannikouris F. Losartan prevents the elevation of Canadian Interventional Radiology Association (CIRA), Elbadawi A, Mentias A, Elgendy IY, Mohamed AH, blood pressure in adipose-PRR deficient female mice Heart Rhythm Society (HRS), Indian Society of Vascular Syed MH, Ogunbayo GO, Olorunfemi O, Gosev I, Prasad Ferraris VA. A “simple” way for enhanced exosomes to while elevated circulating sPRR activates the renin-an- and Interventional Radiology (ISVIR), Vascular Access S, Cameron SJ. National trends and outcomes for alter gene expression: Simple but wrong-complex but giotensin system. Am J Physiol Heart Circ Physiol. Society of the Americas (VASA), and Vascular Access extra-corporeal membrane oxygenation use in high-risk right. J Thorac Cardiovasc Surg. 2019 Apr 17. pii: S0022- 2019;316:H506-h515. Society of Britain and Ireland (VASBI). J Vasc Access. pulmonary embolism. Vasc Med. 2019 Jun;24(3):230-233. 5223(19)30729-9. doi: 10.1016/j.jtcvs.2019.03.053. 2019;20:114-122. doi: 10.1177/1358863X18824650. Gatineau E, Gong MC, Yiannikouris F. Soluble Prorenin Ferraris VA. Bundled Payments for Surgical Care- Receptor Increases Blood Pressure in High Fat-Fed Dungan CM, Murach KA, Frick KK, Jones SR, Crow SE, El-Helw M, Chelvarajan L, Abo-Aly M, Soliman M, More Questions Than Answers. Semin Thorac Male Mice. Hypertension. 2019 Oct;74(4):1014-1020. doi: Englund DA, Vechetti IJ Jr, Figueiredo VC, Levitan BM, Milburn G, Conger AL, Campbell K, Ratajczak MZ, Cardiovasc Surg. 2019 Spring;31(1):38-39. doi: 10.1053/j. 10.1161/HYPERTENSIONAHA.119.12906. Satin J, McCarthy JJ, Peterson CA. Elevated myonuclear Abdel-Latif A. Identification of Human Very Small semtcvs.2018.09.023. density during skeletal muscle hypertrophy in response Embryonic like Stem Cells (VSELS) in Human Heart Geng X, Irvin MR, Hidalgo B, Aslibekyan S, to training is reversed during detraining. Am J Physiol Tissue Among Young and Old Individuals. Stem Cell Rev Ferraris VA. The Complexities of Measuring Health- Srinivasasainagendra V, An P, Frazier-Wood AC, Tiwari Cell Physiol. 2019 May 1;316(5):C649-C654. doi: 10.1152/ Rep. 2019 Nov 22. doi: 10.1007/s12015-019-09923-1. Related Quality of Life After Complicated Cardiac HK, Dave T, Ryan K, Ordovas JM, Straka RJ, Feitosa ajpcell.00050.2019. Operations. What Happens When You Go Home? Semin MF, Hopkins PN, Borecki I, Province MA, Mitchell BD, Endean ED. Reassessment of forearm basilic arterio- Thorac Cardiovasc Surg. 2019 May 22. pii: S1043- Arnett DK and Zhi D. An Exome-Wide Sequencing Study Eaton M, Scully R, Schuller M, Yang A, Smink D, venous fistula. J Vasc Surg. 2019 Oct;70(4):1253. doi: 0679(19)30145-5. doi: 10.1053/j.semtcvs.2019.05.018. of the GOLDN Cohort Reveals Novel Associations of Williams RG, Bohnen JD, George BC, Fryer JP, 10.1016/j.jvs.2019.02.052. Coding Variants and Fasting Plasma Lipids. Front Genet. Meyerson SL. Value and Barriers to Use of the SIMPL Ferraris VA, Pezzella AT. Commentary: Worldwide 2019;10:158. Tool for Resident Feedback. J Surg Educ. 2019 May - Expert Panel on Thoracic Imaging, Lee C, Colletti disparities in cardiac surgical care: Thinking globally Jun;76(3):620-627. doi: 10.1016/j.jsurg.2019.01.012. PM, Chung JH, Ackman JB, Berry MF, Carter BW, not locally to solve problems of limited resources and George B, Misumida N, Ziada KM. Revascularization de Groot PM, Hobbs SB, Johnson GB, Maldonado F, access to specialized care. J Thorac Cardiovasc Surg. Strategies for Non-ST-Elevation Myocardial Infarction. Edgar RJ, van Hensbergen VP, Ruda A, Turner AG, McComb BL, Tong BC, Walker CM, Kanne JP. ACR 2019 May 16. pii: S0022-5223(19)31000-1. doi: 10.1016/j. Curr Cardiol Rep. 2019 Apr 10;21(5):39. doi: 10.1007/ Deng P, Le Breton Y, El-Sayed NM, Belew AT, McIver KS, Appropriateness Criteria® Acute Respiratory Illness in jtcvs.2019.04.070. s11886-019-1125-9. McEwan AG, Morris AJ, Lambeau G, Walker MJ, Rush Immunocompromised Patients. J Am Coll Radiol. 2019 JS, Korotkov KV, Widmalm G, van Sorge NM, Korotkova Nov;16(11S):S331-S339. doi: 10.1016/j.jacr.2019.05.019. Ferraris VA, Shander A. Commentary: Is transfusion Ghazi L, Pajewski NM, Rifkin DE, Bates JT, Chang TI, N. Discovery of glycerol phosphate modification on as simple as Goldilocks makes it? “For every complex Cushman WC, Glasser SP, Haley WE, Johnson KC, Kostis streptococcal rhamnose polysaccharides. Nat Chem Biol. Faggioni M, Baber U, Sartori S, Chandrasekhar problem there is an answer that is clear, simple, and WJ, Papademetriou V, Rahman M, Simmons DL, Taylor 2019 May;15(5):463-471. doi: 10.1038/s41589-019-0251-4. J, Cohen DJ, Henry TD, Claessen BE, Dangas GD, wrong”.J Thorac Cardiovasc Surg. 2019 May 17. pii: A, Whelton PK, Wright JT, Bhatt UY, Drawz PE. Effect Gibson CM, Krucoff MW, Vogel B, Moliterno DJ, S0022-5223(19)31017-7. doi: 10.1016/j.jtcvs.2019.02.140. of Intensive and Standard Clinic-Based Hypertension Elbadawi A, Barssoum K, Abuzaid AS, Rezq A, Biniwale Sorrentino S, Colombo A, Chieffo A, Kini A, Farhan Management on the Concordance Between Clinic N, Alotaki E, Mohamed AH, Vuyyala S, Ogunbayo GO, S, Ariti C, Witzenbichler B, Weisz G, Steg PG, Pocock and Ambulatory Blood Pressure and Blood Pressure Saad M. Meta-analysis of randomized trials on percu- S, Mehran R. Influence of Baseline Anemia on Dual Variability in SPRINT. J Am Heart Assoc. 2019 Jul taneous patent foramen ovale closure for prevention Antiplatelet Therapy Cessation and Risk of Adverse 16;8(14):e011706. doi: 10.1161/JAHA.118.011706. 56 | UK Gill Heart & Vascular Institute Publications | 57

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Gleason TG, Argenziano M, Bavaria JE, Kane LC, Haedtke CA, Moser DK, Pressler SJ, Chung ML, Wingate Holmstrom AL, Meyerson SL. Obtaining Meaningful Jang JJ, Bhapkar M, Coles A, Vemulapalli S, Fordyce Coselli JS, Engelman RM, Tanaka KA, Awad A, Sekela S, Goodlin SJ. Influence of depression and gender on Assessment in Thoracic Surgery Education. Thorac CB, Lee KL, Udelson JE, Hoffmann U, Tardif JC, Jones ME, Zwischenberger JB. Hemoadsorption to Reduce symptom burden among patients with advanced heart Surg Clin. 2019 Aug;29(3):239-247. doi: 10.1016/j. WS, Mark DB, Sorrell VL, Espinoza A, Douglas PS, Patel Plasma-Free Hemoglobin During Cardiac Surgery: failure: Insight from the pain assessment, incidence and thorsurg.2019.03.002. MR; PROMISE Investigators. Predictive Model for Results of REFRESH I Pilot Study. Semin Thorac nature in heart failure study. Heart Lung. 2019 May - High-Risk Coronary Artery Disease. Circ Cardiovasc Cardiovasc Surg. 2019 Winter;31(4):783-793. doi: 10.1053/j. 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Am J Transplant. 2019 Jun 14. doi: Biphenyls Compromise the Liver Promoting Diet-Induced Hoogland AI, Jim HSL, Schoenberg NE, Watkins JF, Influencing Diet-induced Obesity in Mice. Sci Rep. 2019 10.1111/ajt.15492. Steatohepatitis. J Proteome Res. 2019 Apr 5;18(4):1582- Rowles GD. Positive Psychological Change Following Sep 2;9(1):12626. doi: 10.1038/s41598-019-49090-4. 1594. doi: 10.1021/acs.jproteome.8b00886. a Cancer Diagnosis in Old Age: A Mixed-Methods Gordon SM, Neufeld EB, Yang Z, Pryor M, Freeman LA, Study. Cancer Nurs. 2019 Dec 6. doi: 10.1097/ Johnson NF, Gold BT, Ross D, Bailey AL, Clasey Fan X, Kullo IJ, Biesecker LG, Remaley AT. DENND5B Harris DD, 2nd, Shafii AE, Baz M, Tribble TA, Ferraris NCC.0000000000000766. JL, Gupta V, Leung SW, Powell DK. Non-fasting Regulates Intestinal Triglyceride Absorption and VA. Increased blood transfusion and its impact in patients High-Density Lipoprotein Is Associated With White Body Mass. Sci Rep. 2019 Mar 5;9(1):3597. doi: 10.1038/ having tracheostomy while on extracorporeal membrane Hou T, Su W, Guo Z, Gong MC. A Novel Diabetic Matter Microstructure in Healthy Older Adults. Front s41598-019-40296-0. oxygenation. Perfusion. 2019;34:143-146. Mouse Model for Real-Time Monitoring of Clock Gene Aging Neurosci. 2019 May 7;11:100. doi: 10.3389/ Oscillation and Blood Pressure Circadian Rhythm. J Biol fnagi.2019.00100. Gottipati A, Chelvarajan L, Peng H, Kong R, Cahall CF, Li C, Hennig B. International scientists seek solutions for Rhythms. 2019;34:51-68. Tripathi H, Al-Darraji A, Ye S, Elsawalhy E, Abdel-Latif A, environmental problems. Rev Environ Health. 2019 Sep Joyce LC, Baber U, Claessen BE, Sartori S, Berron BJ. Gelatin Based Polymer Cell Coating Improves 25;34(3):225. doi: 10.1515/reveh-2019-0058. Immanuel CN, Teng B, Dong B, Gordon EM, Kennedy JA, Chandrasekhar J, Cohen DJ, Henry TD, Ariti C, Dangas Bone Marrow-Derived Cell Retention in the Heart after Luellen C, Schwingshackl A, Cormier SA, Fitzpatrick G, Faggioni M, Aoi S, Gibson CM, Aquino M, Krucoff MW, Myocardial Infarction. Stem Cell Rev. 2019 Jun;15(3):404- Heo S, McSweeney J, Tsai PF, Ounpraseuth S, Moser DK, EA, Waters CM. Apoptosis signal-regulating kinase-1 Vogel B, Moliterno DJ, Sorrentino S, Colombo A, Chieffo 414. doi: 10.1007/s12015-018-9870-5. Kim J. The Associations of Diagnoses of Fatigue and promotes inflammasome priming in macrophages. Am J A, Kini A, Guedeney P, Witzenbichler B, Weisz G, Steg PG, Depression With Use of Medical Services in Patients With Physiol Lung Cell Mol Physiol. 2019;316:L418-l427. Pocock S, Mehran R. Dual-Antiplatelet Therapy Cessation Gourgari E, Ma J, Playford MP, Mehta NN, Goldman Heart Failure. J Cardiovasc Nurs. 2019 Jul/Aug;34(4):289- and Cardiovascular Risk in Relation to Age: Analysis R, Remaley AT, Gordon SM. Proteomic alterations of 296. doi: 10.1097/JCN.0000000000000574. Iniesta R, Campbell D, Venturini C, Faconti L, Singh From the PARIS Registry. JACC Cardiovasc Interv. 2019 HDL in youth with type 1 diabetes and their associ- S, Irvin MR, Cooper-DeHoff RM, Johnson JA, Turner May 27;12(10):983-992. doi: 10.1016/j.jcin.2019.02.033. ations with glycemic control: a case-control study. Heo S, Moser DK, Lennie TA, Grudnowski S, Kim J ST, Arnett DK, Weale ME, Warren H, Munroe PB, Cardiovasc Diabetol. 2019 Mar 28;18(1):43. doi: 10.1186/ and Turrise S. Patients’ Beliefs About Causes and Cruickshank K, Padmanabhan S, Lewis C, Chowienczyk Kamatham S, Waters CM, Schwingshackl A, Mancarella s12933-019-0846-9. Consequences of Heart Failure Symptoms. West J Nurs P. Gene Variants at Loci Related to Blood Pressure S. TREK-1 protects the heart against ischemia-reper- Res. 2019:193945918823786. Account for Variation in Response to Antihypertensive fusion-induced injury and from adverse remodeling Grewal P, Lahoti S, Aroor S, Snyder K, Pettigrew LC, Drugs Between Black and White Individuals. after myocardial infarction. Pflugers Arch. 2019 Goldstein LB. Effect of Known Atrial Fibrillation Hidalgo BA, Sofer T, Qi Q, Schneiderman N, Chen YI, Hypertension. 2019 Sep;74(3):614-622. doi: 10.1161/ Oct;471(10):1263-1272. doi: 10.1007/s00424-019-02306-y. and Anticoagulation Status on the Prehospital Kaplan RC, Aviles-Santa ML, North KE, Arnett DK, Szpiro HYPERTENSIONAHA.118.12177. Identification of Large Vessel Occlusion. J Stroke A, Cai J, Yu B, Boerwinkle E, Papanicolaou G, Laurie CC, Kapoor H, Ramy Elashery A, El Khouli R, Zagurovskaya Cerebrovasc Dis. 2019 Sep 26:104404. doi: 10.1016/j. Rotter JI and Stilp AM. Associations between SLC16A11 Jackson EN, Thatcher SE, Larian N, English V, Soman M. Accessory Hepatic Caval Foraminal Herniation jstrokecerebrovasdis.2019.104404. variants and diabetes in the Hispanic Community Health S, Morris AJ, Weng J, Stromberg A, Swanson HI, Mimicking a Right Atrial Mass. Circ Cardiovasc Study/Study of Latinos (HCHS/SOL). Scientific reports. Pearson K, Cassis LA. Effects of Aryl Hydrocarbon Imaging. 2019;12:e008765. Guglin M, Zucker MJ, Bazan VM, Bozkurt B, El Banayosy 2019;9:843. Receptor Deficiency on PCB-77-Induced Impairment A, Estep JD, Gurley J, Nelson K, Malyala R, Panjrath of Glucose Homeostasis during Weight Loss in Male Kathuria-Prakash N, Moser DK, Alshurafa N, Watson GS, Zwischenberger JB, Pinney SP. Venoarterial ECMO Hillerson D, Ogunbayo GO, Salih M, Misumida N, and Female Obese Mice. Environ Health Perspect. 2019 K, Eastwood JA. Young African American women’s for Adults: JACC Scientific Expert Panel. Journal of the Abdel-Latif A, Smyth SS, Messerli AW. Outcomes and Jul;127(7):77004. doi: 10.1289/EHP4133. participation in an m-Health study in cardiovascular American College of Cardiology. 2019;73:698-716. Characteristics of Myocardial Infarction in Patients With risk reduction: Feasibility, benefits, and barriers. Cirrhosis. J Invasive Cardiol. 2019 Jul;31(7):E162-E169. Jafari N, Drury J, Morris AJ, Onono FO, Stevens PD, Gao Eur J Cardiovasc Nurs. 2019 Oct;18(7):569-576. doi: Gwag T, Meng Z, Sui Y, Helsley RN, Park SH, Wang S, T, Liu J, Wang C, Lee EY, Weiss HL, Evers BM, Zaytseva 10.1177/1474515119850009. Greenberg RN, Zhou C. Non-nucleoside reverse transcrip- YY. De Novo Fatty Acid Synthesis-Driven Sphingolipid tase inhibitor efavirenz activates PXR to induce hyper- Metabolism Promotes Metastatic Potential of Colorectal cholesterolemia and hepatic steatosis. J Hepatol. 2019 Cancer. Mol Cancer Res. 2019;17:140-152. May;70(5):930-940. doi: 10.1016/j.jhep.2018.12.038. 58 | UK Gill Heart & Vascular Institute Publications | 59

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Kim S, Graham MJ, Lee RG, Yang L, Kim S, Subramanian MJ, Ramanathan RK, Carpenter EL, Ji A, de Beer MC, Li X, Wood JP. Studies into prekallikrein activation pave Messerli FH, Bangalore S, Messerli AW. Meta- V, Layne JD, Cai L, Temel RE, Shih D, Lusis AJ, Berliner de Beer FC, Webb NR, Beatty GL. Hepatocytes direct the the way for new avenues of antithrombotic research. J Analysis in the Mirror of its Quotations: Science, JA, Lee S. Heparin-binding EGF-like growth factor formation of a pro-metastatic niche in the liver. Nature. Thromb Haemost. 2019 May;17(5):717-719. doi: 10.1111/ Scepticism, Scorn, and Sarcasm. Eur Heart J. 2019 Oct (HB-EGF) antisense oligonucleotide protected against 2019;567:249-252. jth.14435. 21;40(40):3290-3291. doi: 10.1093/eurheartj/ehz702. hyperlipidemia-associated atherosclerosis. Nutr Metab Cardiovasc Dis. 2019;29:306-315. Lee KS, Kim JH, Kang KW, Miller J, McEvedy SM, Hwang Li Z, Huang Y, Wu Y, Chen J, Wu D, Zhan CG, Luo HB. Messerli FH, Neagoe, Messerli AW. The alcohol SY, Moser DK. Implantable Cardioverter Defibrillator Absolute Binding Free Energy Calculation and Design blood pressure paradox. European heart journal. Kraemer MP, Mao G, Hammill C, Yan B, Li Y, Onono F, Shocks and Psychological Distress: Examining of a Subnanomolar Inhibitor of Phosphodiesterase-10. J 2019;40:711-712. Smyth SS, Morris AJ. Effects of diet and hyperlipidemia the Mediating Roles of Implantable Cardioverter Med Chem. 2019;62:2099-2111. on levels and distribution of circulating lysophosphatid- Defibrillator-Related Concerns and Perceived Messerli AW, Ziada KM, Whayne TF Jr. Dark Spots ic acid. J Lipid Res. 2019 Nov;60(11):1818-1828. doi: Control. J Cardiovasc Nurs. 2019 Aug 21. doi: 10.1097/ Lifsey HC, Kaur R, Thompson BH, Bennett L, Temel in Bright Clouds: The Ominous Significance of Spotty 10.1194/jlr.M093096. JCN.0000000000000610. RE, Graf GA. Stigmasterol stimulates transintestinal Calcification. Angiology. 2019 Oct;70(9):793-794. doi: cholesterol excretion independent of liver X receptor 10.1177/0003319718822651. Kuan W, Dulnuan K, Guglin ME, El Haddad H, Kolodziej Lee KS, Feltner FJ, Bailey AL, Lennie TA, Chung ML, activation in the small intestine. J Nutr Biochem. 2019 AR, Leventhal A, Rajagopalan N. A “Cat”-astrophic Case Smalls BL, Schuman DL, Moser DK. The relationship Nov 9;76:108263. doi: 10.1016/j.jnutbio.2019.108263. Meyerson SL, Odell DD, Zwischenberger JB, Schuller of Bartonella henselae infective endocarditis followed by between psychological states and health perception in M, Williams RG, Bohnen JD, Dunnington GL, Torbeck L, cardiac transplantation salvage therapy. Transpl Infect individuals at risk for cardiovascular disease. Psychol Littrell OM, Stoeger C, Maier H, Fuchs H, Hrabě de Mullen JT, Mandell SP, Choti MA, Foley E, Are C, Auyang Dis. 2019 Dec;21(6):e13179. doi: 10.1111/tid.13179. Res Behav Manag. 2019 May 7;12:317-324. doi: 10.2147/ Angelis M, Cassis LA, Gerhardt GA, Grondin R, Gailus- E, Chipman J, Choi J, Meier AH, Smink DS, Terhune PRBM.S198280. Durner V. Costs of Implementing Quality in Research KP, Wise PE, Soper N, Lillemoe K, Fryer JP, George BC; Kukida M, Sawada H, Daugherty A, Lu HS. Megalin: Practice. Handb Exp Pharmacol. 2019 Sep 21. doi: Procedural Learning and Safety Collaborative. The effect A bridge connecting kidney, the renin-angiotensin Lehnert AL, Hart A, Brouse SD, Charnigo RJ, Branam 10.1007/164_2019_294. of gender on operative autonomy in general surgery res- system, and atherosclerosis. Pharmacol Res. 2019 Nov S, Guglin ME. Left ventricular assist device-related idents. Surgery. 2019 Nov;166(5):738-743. doi: 10.1016/j. 7;151:104537. doi: 10.1016/j.phrs.2019.104537. infections: does the time of onset matter? J Artif Organs. Lu HS, Kukida M, Daugherty A. Links lipoproteins surg.2019.06.006. 2019 Jun;22(2):98-103. doi: 10.1007/s10047-018-1078-6. to chronic kidney disease and atherosclerosis. Curr Kwong RY, Ge Y, Steel K, Bingham S, Abdullah S, Opin Lipidol. 2019 Oct;30(5):410-411. doi: 10.1097/ Miller JL, Chung ML, Etaee F, Hammash M, Thylén Fujikura K, Wang W, Pandya A, Chen YY, Mikolich JR, Lenchik L, Heacock L, Weaver AA, Boutin RD, Cook TS, MOL.0000000000000625. I, Biddle MJ, Elayi SC, Czarapata MM, McEvedy S, Boland S, Arai AE, Bandettini WP, Shanbhag SM, Patel Itri J, Filippi CG, Gullapalli RP, Lee J, Zagurovskaya Cameron J, Haedtke CA, Ski CF, Thompson DR, Moser AR, Narang A, Farzaneh-Far A, Romer B, Heitner JF, Ho M, Retson T, Godwin K, Nicholson J, Narayana PA. Lu W, Park SH, Meng Z, Wang F, Zhou C. Deficiency DK. Missed opportunities! End of life decision making JY, Singh J, Shenoy C, Hughes A, Leung SW, Marji M, Automated Segmentation of Tissues Using CT and MRI: of Adipocyte IKKβ Affects Atherosclerotic Plaque and discussions in implantable cardioverter defibrillator Gonzalez JA, Mehta S, Shah DJ, Debs D, Raman SV, Guha A Systematic Review. Acad Radiol. 2019 Dec;26(12):1695- Vulnerability in Obese LDLR Deficient Mice. J Am recipients. Heart Lung. 2019 Jul - Aug;48(4):313-319. doi: A, Ferrari VA, Schulz-Menger J, Hachamovitch R, Stuber 1706. doi: 10.1016/j.acra.2019.07.006. Heart Assoc. 2019 Jun 18;8(12):e012009. doi: 10.1161/ 10.1016/j.hrtlng.2019.04.006. M, Simonetti OP. Cardiac Magnetic Resonance Stress JAHA.119.012009. Perfusion Imaging for Evaluation of Patients With Chest LeVine DN, Cianciolo RE, Linder KE, Bizikova P, Miller L, Birks E, Guglin M, Lamba H, Frazier Pain. J Am Coll Cardiol. 2019 Oct 8;74(14):1741-1755. doi: Birkenheuer AJ, Brooks MB, Salous AK, Nordone SK, McKee G, Mooney M, O’Donnell S, O’Brien F, Biddle MJ, OH. Use of Ventricular Assist Devices and Heart 10.1016/j.jacc.2019.07.074. Bellinger DA, Marr H, Jones SL, Fischer TH, Deng Moser DK. A cohort study examining the factors influ- Transplantation for Advanced Heart Failure. Circ Y, Mazepa M, Key NS. Endothelial alterations in a encing changes in physical activity levels following an Res. 2019 May 24;124(11):1658-1678. doi: 10.1161/ Lakie M, Campbell KS. Muscle thixotropy-where are we canine model of immune thrombocytopenia. Platelets. acute coronary syndrome event. Eur J Cardiovasc Nurs. CIRCRESAHA.119.313574. now? J Appl Physiol (1985). 2019 Jun 1;126(6):1790-1799. 2019;30:88-97. 2019;18:57-66. doi: 10.1152/japplphysiol.00788.2018. Misumida N, Ogunbayo GO, Catanzaro J, Etaee F, Kim Li F, Shi J, Lu HS, Zhang H. Functional Genomics Mao G, Smyth SS, Morris AJ. Regulation of PLPP3 gene SM, Abdel-Latif A, Ziada KM, Elayi CS. Contemporary Larian N, Ensor M, Thatcher SE, English V, Morris AJ, and CRISPR Applied to Cardiovascular Research expression by NF-κB family transcription factors. J Biol practice pattern of permanent pacing for conduction Stromberg A, Cassis LA. Pseudomonas aeruginosa-de- and Medicine. Arterioscler Thromb Vasc Biol. 2019 Chem. 2019 Sep 20;294(38):14009-14019. doi: 10.1074/jbc. disorders in inferior ST-elevation myocardial infarction. rived pyocyanin reduces adipocyte differentiation, body Sep;39(9):e188-e194. doi: 10.1161/ATVBAHA.119.312579. RA119.009002. Clin Cardiol. 2019 Aug;42(8):728-734. doi: 10.1002/ weight, and fat mass as mechanisms contributing to clc.23210. septic cachexia. Food Chem Toxicol. 2019 Aug;130:219- Li J, Pijut SS, Wang Y, Ji A, Kaur R, Temel RE, van der Meng Z, Gwag T, Sui Y, Park SH, Zhou X, Zhou C. The 230. doi: 10.1016/j.fct.2019.05.012. Westhuyzen DR, Graf GA. Simultaneous Determination atypical antipsychotic quetiapine induces hyperlipid- Misumida N, Ogunbayo GO, Kim SM, Abdel-Latif A, of Biliary and Intestinal Cholesterol Secretion Reveals emia by activating intestinal PXR signaling. JCI Insight. Ziada KM, Sorrell VL. Clinical Outcome of Takotsubo Lee JW, Stone ML, Porrett PM, Thomas SK, Komar CA, Li That CETP (Cholesteryl Ester Transfer Protein) Alters 2019;4. Cardiomyopathy Diagnosed With or Without Coronary JH, Delman D, Graham K, Gladney WL, Hua X, Black TA, Elimination Route in Mice. Arterioscler Thromb Angiography. Angiology. 2019;70:56- Chien AL, Majmundar KS, Thompson JC, Yee SS, O’Hara Vasc Biol. 2019 Oct;39(10):1986-1995. doi: 10.1161/ MH, Aggarwal C, Xin D, Shaked A, Gao M, Liu D, Borad ATVBAHA.119.312952. 60 | UK Gill Heart & Vascular Institute Publications | 61

PUBLICATIONS

Misumida N, Pagath M, Ogunbayo GO, Wilson RE, Kim Mullis AH, Ayoub K, Shah J, Butt M, Suffredini J, Ogunbayo GO, Messerli AW, Ha LD, Elbadawi A, vesicle fission requires shorter forms of phosphatidic SM, Abdel-Latif A, Elayi CS. Characteristics of and Czarapata M, Delisle B, Ogunbayo GO, Darrat Y, Olorunfemi O, Darrat Y, Guglin M, Okwechime R, acid and diacylglycerol. Nat Commun. 2019 Jul current practice patterns of pacing for high-degree Elayi CS. Fluctuations in premature ventricular con- Akanya D, Abdel-Latif A, Smyth SS, Elayi CS. Trends 30;10(1):3409. doi: 10.1038/s41467-019-11324-4. atrioventricular block after transcatheter aortic valve traction burden can impact medical assessment and in the Incidence and In-Hospital Outcomes of Patients implantation in comparison to surgical aortic valve management. Heart Rhythm. 2019 Apr 18. pii: S1547- With Atrial Fibrillation Complicated by Non-ST-Segment Phung TN, Sinclair SE, Makena P, Molthen RC, Waters replacement. Catheter Cardiovasc Interv. 2019 Jun 5271(19)30362-5. doi: 10.1016/j.hrthm.2019.04.033. Elevation Myocardial Infarction. Angiology. 2019 CM. Dynamic airway constriction in rats: heterogeneity 1;93(7):E385-E390. doi: 10.1002/ccd.27915. Apr;70(4):317-324. doi: 10.1177/0003319718801087. and response to deep inspiration. Am J Physiol Lung Musa T, Darrat Y, Etaee F, Butt M, Czarapata M, Cell Mol Physiol. 2019 Jul 1;317(1):L39-L48. doi: 10.1152/ Moalem K, Baber U, Chandrasekhar J, Claessen BE, McMullen C, Mattingly L, Daoud A, Coy K, Ogunbayo G, Ogunbayo GO, Misumida N, Goodwin E, Pecha R, ajplung.00050.2019. Sartori S, Aquino M, Dangas G, Iakovou I, Colombo Delisle B, Elayi CS. Gender differences in management of Elbadawi A, Elayi CS, Abdel-Latif A, Gurley J, Messerli A, Kini A, Gibson M, Krucoff M, Chieffo A, Moliterno patients undergoing catheter ablation of atrioventricular AW, Ziada K. Characteristics, Outcomes, and Predictors Prueksaritanond S, Abdel-Latif A. ST-Segment Elevation D, Witzenbichler B, Pocock S, Mehran R. Incidence, nodal reentry tachycardia. Pacing Clin Electrophysiol. of Significant Pericardial Complications in Patients who Myocardial Infarction Patients in the Coronary Care predictors, and outcomes of DAPT disruption due to 2019 May 30. doi: 10.1111/pace.13735. Underwent Transcatheter Aortic Valve Implantation. Unit: Is it Time to Break Old Habits? JACC Cardiovasc non-compliance vs. bleeding after PCI: insights from the Am J Cardiol. 2019 Jul 15;124(2):321-322. doi: 10.1016/j. Interv. 2019 Apr 22;12(8):718-720. doi: 10.1016/j. PARIS Registry. Clin Res Cardiol. 2019. Newman CB, Preiss D, Tobert JA, Jacobson TA, Page amjcard.2019.04.036. jcin.2019.02.028. RL, 2nd, Goldstein LB, Chin C, Tannock LR, Miller M, Modi AR, Miranda CC, Procop GW, Foster CB, Raghuveer G, Duell PB, Brinton EA, Pollak A, Braun Ogunbayo GO, Pecha R, Misumida N, Goodwin E, Raissi D, Roney EA, Issa MM, Sanampudi S, Winkler Harrington S, Evans D, Johnson LT, Gordon SM. LT, Welty FK. Statin Safety and Associated Adverse Ayoub K, Hillerson D, Elbadawi A, Abdel-Latif A, Elayi MA. Early TIPS failure in association with left mesen- Addressing the threat from within: Investigation of Events: A Scientific Statement From the American CS, Messerli AW, Smyth SS. Outcomes of fibrinolytic terico-gonadal spontaneous portosystemic venous shunt; respiratory symptoms in a health care worker with Heart Association. Arterioscler Thromb Vasc Biol. therapy for patients with metastatic cancer and acute a case report. Clin Imaging. 2019;53:200-203. untreated latent tuberculosis infection. Am J Infect 2019;39:e38-e81. pulmonary embolism. Pulm Pharmacol Ther. 2019 Control. 2019 Aug 20. pii: S0196-6553(19)30692-3. doi: Jun;56:104-107. doi: 10.1016/j.pupt.2019.04.001. Ramachandran P, Serai SD, Veldtman GR, Lang SM, 10.1016/j.ajic.2019.07.012. O’Donnell S, Monahan P, McKee G, McMahon G, Curtin E, Mazur W, Trout AT, Dillman JR, Fleck RJ, Taylor MD, Farrell S, Moser D. Towards prompt electrocardiogram Ogunbayo GO, Shrout TA, Misumida N, Abdel-Latif A, Alsaied T, Moore RA. Assessment of liver T1 mapping Moga DC, Abner EL, Rigsby DN, Eckmann L, Huffmyer acquisition in triage: Preliminary testing of a symp- Smyth SS, Messerli AW, Ziada KM. Trends, Management in fontan patients and its correlation with magnetic M, Murphy RR, Coy BB, Jicha GA. Optimizing medication tom-based clinical prediction rule for the Android tablet. Patterns, and Predictors of Leaving Against Medical resonance elastography-derived liver stiffness. Abdom appropriateness in older adults: a randomized clinical Eur J Cardiovasc Nurs. 2019 Apr;18(4):289-298. doi: Advice among Patients with Documented Noncompliance Radiol (NY). 2019 Jul;44(7):2403-2408. doi: 10.1007/ interventional trial to decrease anticholinergic burden. 10.1177/1474515118821023. Admitted for Acute Myocardial Infarction. J Gen s00261-019-01990-9. Alzheimers Res Ther. 2017;9:36. Intern Med. 2019 Apr;34(4):486-488. doi: 10.1007/ Ogunbayo GO, Elayi SC, Ha LD, Olorunfemi O, Elbadawi s11606-018-4671-8. Ravichandran S, Finlin BS, Kern PA, Ozcan S. Sphk2(-/-) Mooney M, McKee G, McDermott E, O’Donnell S, Ryan A, Saheed D, Sorrell VL. Outcomes of Heart Block in mice are protected from obesity and insulin resistance. P, Moser D, O’Brien F. Patients’ knowledge and opinions Myocarditis: A Review of 31,760 Patients. Heart Lung Omotola O, Legan S, Slade E, Adekunle A, Pendergast JS. Biochim Biophys Acta Mol Basis Dis. 2019;1865:570-576. of ICDs during life, illness and at the time of death. Circ. 2019;28:272-276. Estradiol regulates daily rhythms underlying diet-in- Br J Nurs. 2019 Apr 11;28(7):446-451. doi: 10.12968/ duced obesity in female mice. Am J Physiol Endocrinol Reynolds LJ, Chavan NR, DeHoff LB, Preston JD, bjon.2019.28.7.446. Ogunbayo GO, Goodwin RP, Elbadawi A, Omar M, Metab. 2019 Dec 1;317(6):E1172-E1181. doi: 10.1152/ Maddox HF, O’Brien JM, Armstrong DA, Marsit CJ, Hillerson D, Goodwin EM, Pecha R, Abdel-Latif A, ajpendo.00365.2019. Pearson KJ. Smoking during pregnancy increases Morris AJ. Phospholipases D- making sense of redun- Elayi CS, Messerli AW. Temporal Trends in the Use of chemerin expression in neonatal tissue. Exp Physiol. dancy and duplication. Biosci Rep. 2019 Jun 12. pii: Intravascular Imaging Among Patients Undergoing Page MJ, Thomson GJA, Nunes JM, Engelbrecht AM, 2019;104:93-99. BSR20181883. doi: 10.1042/BSR20181883. Percutaneous Coronary Intervention for ST Elevation Nell TA, de Villiers WJS, de Beer MC, Engelbrecht L, Kell Myocardial Infarction in the United States. Am J DB, Pretorius E. Serum amyloid A binds to fibrin(ogen), Ruddell JH, Eltorai AEM, Tang OY, Suskin JA, Dibble Mottaleb MA, Petriello MC, Morris AJ. High throughput Cardiol. 2019 Nov 15;124(10):1650-1652. doi: 10.1016/j. promoting fibrin amyloid formation. Scientific reports. EH, Oates ME, Yoo DC. The Current State of Nuclear UHPLC MS/MS measurement of Per and Poly Fluorinated amjcard.2019.08.022. 2019;9:3102. Medicine and Nuclear Radiology: Workforce Trends, Alkyl Substances (PFAS) in human serum. J Anal Toxicol. Training Pathways, and Training Program Websites. 2019 Nov 27. pii: bkz097. doi: 10.1093/jat/bkz097. Ogunbayo GO, Ha LD, Ahmad Q, Misumida N, Pandeya A, Li L, Li Z, Wei Y. Gasdermin D (GSDMD) Acad Radiol. 2019 Nov 21. pii: S1076-6332(19)30482-9. Okwechime R, Elbadawi A, Abdel-Latif A, Elayi CS, as a new target for the treatment of infection. doi: 10.1016/j.acra.2019.09.026. Mueller PA, Yang L, Ubele M, Mao G, Brandon J, Vandra Smyth S, Boccara F, Messerli AW. Treatment Bias Medchemcomm. 2019 Apr 4;10(5):660-667. doi: 10.1039/ J, Nichols TC, Escalante-Alcalde D, Morris AJ, Smyth in Management of HIV Patients Admitted for Acute c9md00059c. Saleh ZT, Lennie TA, Alhurani AS, Almansour IM, SS. Coronary Artery Disease Risk-Associated Plpp3 Gene Myocardial Infarction: Does It Still Exist? J Gen Intern Alduraidi H, Moser DK. High Dietary Sodium Intake and Its Product Lipid Phosphate Phosphatase 3 Regulate is Associated with Shorter Event-Free Survival in Med. 2019 Nov 11. doi: 10.1007/s11606-019-05416-6. Park SY, Yang JS, Li Z, Deng P, Zhu X, Young D, Ericsson Experimental Atherosclerosis. Arterioscler Thromb Patients with Heart Failure and Comorbid Diabetes. M, Andringa RLH, Minnaard AJ, Zhu C, Sun F, Moody Vasc Biol. 2019 Nov;39(11):2261-2272. doi: 10.1161/ Clin Nurs Res. 2019 Nov 18:1054773819888743. doi: DB, Morris AJ, Fan J, Hsu VW. The late stage of COPI ATVBAHA.119.313056. 10.1177/1054773819888743. 62 | UK Gill Heart & Vascular Institute Publications | 63

PUBLICATIONS

Whayne TF. Hypertriglyceridemia: An Infrequent, Wu JR, Song EK, Moser DK, Lennie TA. Dietary Vitamin Zhou C, Wang D, Condemi F, Zhao G, Topaz S, Ballard- Difficult-to-Predict, Severe Metabolic and Vascular C Deficiency Is Associated With Health-Related Quality Croft C, Zwischenberger JB. AvalonElite Double Lumen Problem Associated with Estrogen Administration. Curr of Life and Cardiac Event-free Survival in Adults With Cannula for Total Cavopulmonary Assist in Failing Vasc Pharmacol. 2019. Heart Failure. J Cardiovasc Nurs. 2019;34:29-35. Fontan Sheep Model with Valved Extracardiac Conduit. ASAIO J. 2019 May/Jun;65(4):361-366. doi: 10.1097/ Whayne TF. Non-Traditional Cardiovascular Risk Xenos ES, Davis GA, He Q, Green A, Smyth SS. The MAT.0000000000000817. Markers in the Era of Established Major Risk Factors implementation of a pulmonary embolism response team and Multiple Guidelines. Curr Vasc Pharmacol. in the management of intermediate- or high-risk pul- Zhu Z, Chen J, Wang G, Elsherbini A, Zhong L, Jiang 2019;17:270-277. monary embolism. J Vasc Surg Venous Lymphat Disord. X, Qin H, Tripathi P, Zhi W, Spassieva SD, Morris AJ, 2019 Jul;7(4):493-500. doi: 10.1016/j.jvsv.2018.11.014. Bieberich E. Ceramide regulates interaction of Hsd17b4 Whayne TF, Jr, Saha SP. Genetic Risk, Adherence to a with Pex5 and function of peroxisomes. Biochim Biophys Healthy Lifestyle, and Ischemic Heart Disease. Curr Yanagida R, Seethamraju H, Davenport DL, Tribble Acta Mol Cell Biol Lipids. 2019 Jun 5. pii: S1388- Cardiol Rep. 2019;21:1. TA, Zwischenberger JB, Hoopes CW. Bridging to lung 1981(19)30091-5. doi: 10.1016/j.bbalip.2019.05.017. transplantation with double-lumen venovenous extra- Whayne TF Jr, Shelton JE, Deutsch CR, Messerli A. corporeal membrane oxygenation. Int J Artif Organs. Ziada KM, Misumida N. In Vivo Identification of Healed Imaging Characteristics and Significance of Coronary 2019 Nov;42(11):621-627. doi: 10.1177/0391398819851516. Plaques in Culprit Lesions: Is What We’re Seeing Really Artery Mismatch Lesions. Angiology. 2019 Sep;70(8):685- There? J Am Coll Cardiol. 2019 May 14;73(18):2264-2266. 687. doi: 10.1177/0003319719852843. Yang L, Kraemer M, Fang XF, Angel PM, Drake RR, doi: 10.1016/j.jacc.2019.03.023. Morris AJ, Smyth SS. LPA receptor 4 deficiency atten- Wilsey HA, Pandya K, Beavers C, Xiaoshu L, Ather A. uates experimental atherosclerosis. J Lipid Res. 2019 Comparison of Venous Thromboembolism Prophylactic May;60(5):972-980. doi: 10.1194/jlr.M091066. Measures Post Coronary Artery Bypass Graft Surgery. Am J Cardiovasc Drugs. 2019 Dec;19(6):589-595. doi: Zein AA, Kaur R, Hussein TOK, Graf GA, Lee JY. ABCG5/ 10.1007/s40256-019-00354-4. G8: a structural view to pathophysiology of the hepato- biliary cholesterol secretion. Biochem Soc Trans. 2019 Winkler M, Bayliff S, Issa M, Draus J, Raissi D. Oct 31;47(5):1259-1268. doi: 10.1042/BST20190130. Microvascular volume visualization utilizing computed tomographic angiography data facilitates resection of Zhang Y, Gordon SM, Xi H, Choi S, Paz MA, Sun R, Yang a complicated massive congenital hemangioma. Clin W, Saredy J, Khan M, Remaley AT, Wang JF, Yang X, Imaging. 2019;55:8-11. Wang H. HDL subclass proteomic analysis and func- tional implication of protein dynamic change during Winstead RJ, Waldman G, Autry EB, Evans RA, HDL maturation. Redox Biol. 2019 May 17;24:101222. doi: Schadler A, Kays L, Baz M, Anstead MI, Shafii A, Goetz 10.1016/j.redox.2019.101222. ME. Outcomes of Lung Transplantation for Cystic Fibrosis in the Setting of Extensively Drug-Resistant Zhao G, Zhong Y, Su W, Liu S, Song X, Hou T, Mu X, Gong Organisms. Prog Transplant. 2019 Sep;29(3):220-224. doi: MC, Guo Z. Transcriptional Suppression of CPI-17 Gene 10.1177/1526924819853830. Expression in Vascular Smooth Muscle Cells by Tumor Necrosis Factor, Krüppel-Like Factor 4, and Sp1 Is Wu C, Daugherty A, Lu HS. Updates on Approaches Associated with Lipopolysaccharide-Induced Vascular for Studying AtheroscleroArterioscler Thromb Hypocontractility, Hypotension, and Mortality. Mol Cell Vasc Biol. 2019 Apr;39(4):e108-e117. doi: 10.1161/ Biol. 2019 May 14;39(11). pii: e00070-19. doi: 10.1128/ ATVBAHA.119.312001. sis. MCB.00070-19.

Wu C, Lu W, Zhang Y, Zhang G, Shi X, Hisada Y, Grover Zhao X, Geng X, Srinivasasainagendra V, Chaudhary SP, Zhang X, Li L, Xiang B, Shi J, Li XA, Daugherty A, N, Judd S, Wadley V, Gutierrez OM, Wang H, Lange EM, Smyth SS, Kirchhofer D, Shiroishi T, Shao F, Mackman Lange LA, Woo D, Unverzagt FW, Safford M, Cushman N, Wei Y, Li Z. Inflammasome Activation Triggers Blood M, Limdi N, Quarells R, Arnett DK, Irvin MR, Zhi D. A Clotting and Host Death through Pyroptosis. Immunity. PheWAS study of a large observational epidemiological 2019 Apr 28. pii: S1074-7613(19)30183-9. doi: 10.1016/j. cohort of African Americans from the REGARDS study. immuni.2019.04.003. BMC Med Genomics. 2019;12:26. 64 | UK Gill Heart & Vascular Institute Philanthropy | 65

WHY WE GIVE

Jack and Linda Gill’s legacy is born from a sense of “privilege and obligation”

The best-in-class cardiovascular research and treatment Thus, in 1997, their gift established the Linda and Jack at the Gill Heart & Vascular Institute would not be Gill Heart Institute, as well as an astonishing 19 faculty possible without the benevolence of Linda and Jack chairs/professorships at the University of Kentucky. Gill. Their $5 million gift provided the tools that would They have also supported endowed research, special propel their namesake program to national prominence programs, and the annual Cardiovascular Research Day as a comprehensive academic program in cardiovascular awards and symposia. Their largesse extends to other medicine and science. UK colleges and many other universities as well.

What motivated this engineer-scientist and this “I’ll never forget overhearing a patient from Eastern Kentucky-raised hospital volunteer to create such Kentucky sing the praises of his UK HealthCare doctor,” a legacy? Linda remembers. “It meant that we were overcoming Appalachia’s reluctance to come to Lexington for heart For Jack, who was born into poverty in Texas, intel- care, and it was an honor to be a part of that endeavor.” ligence and hard work were the genesis of a long and fruitful career in science, venture capital, and academia. Their philosophy of leveraged philanthropy—to invest For first-generation college student Linda Challis Gill, a in an idea that transforms a place and its people—is UK scholarship inspired her commitment to “give back” something that they hope to pass on to their children someday. Later, as a volunteer in the cardiovascular and grandchildren, perpetuating good works via the Gill unit in a California hospital, she came to understand Foundation of Texas for generations to come. her beloved Commonwealth’s woeful national rank in cardiovascular health. “We know that not everyone has the means to follow this philosophy,” Jack says. “It’s important to remember that Jack and Linda followed their philanthropic calling every gift—no matter how small—helps advance a noble early on, with modest gifts to UCLA and Stanford, where purpose.” two of their children were enrolled. The list grew with each successive degree—11 in total among their four children.

“We told our children that all universities were equal, but Indiana [University, where Jack attended] and UK were a little more equal,” Jack jokes.

“We believe that our success comes with a privilege and an obligation to help others,” Jack says. “And support for science and medicine—particularly cardiovascular medicine in Kentucky—fused our common interests into one significant endeavor.”

“We believe that our success comes with a privilege and an obligation to help others.” Through their generosity, Linda and Jack Gill - JACK GILL have created a legacy of healthier hearts across the Commonwealth. GILL HEART & VASCULAR INSTITUTE 800 Rose Street Lexington, KY 40536

800-333-8874 (Toll-Free) 859-257-1000

2020 STATE OF TO REFER A PATIENT, PLEASE THE HEART CALL UK·MD’s AT 800-888-5533. TRANSFORMING CARDIOVASCULAR CARE ACROSS KENTUCKY University of Kentucky 2020 2020 STATE OF STATE OF THE HEART THE HEART TRANSFORMING CARDIOVASCULAR TRANSFORMING CARDIOVASCULAR CARE ACROSS KENTUCKY CARE ACROSS KENTUCKY