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PRODUCT INFORMATION Clonazolam Item No. 18173 CAS Registry No.: 33887-02-4 N Formal Name: 6-(2-chlorophenyl)-1-methyl-8- N N nitro-4H-[1,2,4]triazolo[4,3-a][1,4] benzodiazepine Synonym: Clonitrazolam O2N N MF: C17H12ClN5O2 FW: 353.8 Cl Purity: ≥98% Supplied as: A neat solid Storage: -20°C Stability: ≥2 years Information represents the product specifications. Batch specific analytical results are provided on each certificate of analysis. Description Clonazolam is a benzodiazepine that was developed as a central nervous system depressant in the 1970s and has recently emerged as a drug of abuse.1,2 It potently antagonizes convulsions induced 1 by thiosemicarbazide and pentobarbital (ED50s = 90 µg/kg for both agonists in mice). In vitro phase I metabolites of clonazolam, derived from human liver microsomes, have been described.3 This product is intended for forensic and research applications. This product is qualified as a Reference Material that has been manufactured and tested to ISO/IEC 17025 and ISO 17034 international standards. References 1. Hester, J.B., Jr., Rudzik, A.D., and Kamidar, B.V. 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines which have central nervous system depressant activity. J. Med. Chem. 14(11), 1078-1081 (1971). 2. Moosmann, B., King, L.A., and Auwärter, V. Designer benzodiazepines: A new challenge. World Psychiatry 14(2), 248 (2015). 3. Huppertz, L.M., Bisel, P., Westphal, F., et al. Characterization of the four designer benzodiazepines clonazolam, deschloroetizolam, flubromazolam, and meclonazepam, and identification of their in vitro metabolites. Forensic Toxicol. 33(2), 388-395 (2015). WARNING CAYMAN CHEMICAL THIS PRODUCT IS FOR RESEARCH ONLY - NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. 1180 EAST ELLSWORTH RD SAFETY DATA ANN ARBOR, MI 48108 · USA This material should be considered hazardous until further information becomes available. Do not ingest, inhale, get in eyes, on skin, or on clothing. Wash thoroughly after handling. Before use, the user must review the complete Safety Data Sheet, which has been sent via email to your institution. PHONE: [800] 364-9897 WARRANTY AND LIMITATION OF REMEDY [734] 971-3335 Buyer agrees to purchase the material subject to Cayman’s Terms and Conditions. Complete Terms and Conditions including Warranty and Limitation of Liability information can be found on our website. FAX: [734] 971-3640 [email protected] Copyright Cayman Chemical Company, 07/26/2019 WWW.CAYMANCHEM.COM.

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Guaiana, G., Barbui, C., Caldwell, DM, Davies, SJC, Furukawa, TA
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